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This page shows you the most recent publications within this specialty of the MedWorm directory.

Preventive care in general practice among healthy older New South Wales residents
Conclusions: This study demonstrated a gap between reported clinical assessments and preventive advice. There was evidence for inverse care for rural participants and smokers, who despite being at higher risk of health problems, were less likely to report receiving preventive care. This suggests the need for greater effort to promote preventive care for these groups in Australian general practice. (Source: BioMed Central)
Source: BioMed Central - June 15, 2013 Category: Journals (General) Authors: Mark F HarrisFakhrul Md IslamBin JalaludinJack ChenAdrian E BaumanElizabeth Comino Source Type: research

The role of the RNA chaperone Hfq in Haemophilus influenzae pathogenesis
Conclusion: We conclude that Hfq is involved in the utilization of essential nutrients and facilitates infection by H. influenzae. (Source: BioMed Central)
Source: BioMed Central - June 15, 2013 Category: Journals (General) Authors: Randy J HempelDaniel J MortonThomas W SealePaul W WhitbyTerrence L Stull Source Type: research

Towards a novel influenza vaccine: engineering of hemagglutinin on a platform of adenovirus dodecahedron
Conclusions: Engineering of a soluble complex of HA with Dd, a virus-like particle that serves as a vector, an adjuvant and as a multivalent presentation platform, is an important step toward a novel influenza vaccine. (Source: BioMed Central)
Source: BioMed Central - June 15, 2013 Category: Journals (General) Authors: Antonina NaskalskaEwa SzolajskaIgor AndreevMalgorzata PodsiadlaJadwiga Chroboczek Source Type: research

[This Week in Medicine] June 15–21, 2013
In 2011, one in five Americans younger than 65 years had trouble paying medical bills, states the National Health Interview Survey, released by the US Centers for Disease Control and Prevention (CDC). Overall, people having problems paying fell from 21·7% in 2011, to 20·3% in 2012. Women and families with children were more affected than men. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: The Lancet Tags: This Week in Medicine Source Type: research

[Editorial] Reducing gun violence: facts are stubborn things
To take the gun out of politics is a challenge to statesmen worldwide: but in the USA, to take politics out of the gun is seemingly a far more difficult task. The attachment of some Americans to their firearms has many possible explanations. Some have dated it back to the pivotal role of superior US weapons and marksmanship in the War of Independence; others to the Second Amendment to the US Constitution—“A well regulated Militia, being necessary to the security of a free State, the right of the people to keep and bear Arms, shall not be infringed. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research

[Editorial] 30 years of HIV: where next?
Kuala Lumpur will host the 2013 International AIDS Society (IAS) meeting from June 30–July 3. This issue of The Lancet will be there too, with its content rich in the diverse diaspora that characterises global efforts to prevent, treat, and ultimately cure the disease that today affects 34 million people worldwide. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research

[Editorial] The right to health for Syrian refugees
Leaving home can be a difficult decision in some parts of the world. The future is uncertain. Food and shelter may be inadequate. Precarious, cramped living conditions could worsen your health. But for most refugees, there is no choice. Their safety and lives are at risk if they stay. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research

[Comment] A cure for HIV: where we've been, and where we're headed
2013 marks the 30th anniversary of the discovery of HIV. 30 Years of HIV Science: Imagine the Future, a meeting at the Pasteur Institute in Paris, France, in May, 2013, sought to celebrate successes in countering the HIV/AIDS epidemic and to map out the challenges ahead. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Sharon R Lewin Tags: Comment Source Type: research

[Comment] Fighting the HIV epidemic in the Islamic world
Early in the HIV/AIDS epidemic, most predominantly Muslim countries regarded HIV as a disease associated with sexual promiscuity, homosexuality, and drug and alcohol use—behaviours forbidden by Islam. Home to more than 1·6 billion Muslims, the Islamic world was widely believed to be somehow protected against HIV/AIDS. Adherence to Islamic beliefs, together with widespread practice of male circumcision, was thought to protect against the risk of HIV infection, and subsequently to account for a comparatively low HIV prevalence in Muslim majority countries in sub-Saharan Africa and the Middle East. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Adeeba Kamarulzaman Tags: Comment Source Type: research

[Comment] HIV pre-exposure prophylaxis in injecting drug users
Globally, there are an estimated 15·9 million injecting drug users, 3 million of whom have HIV. The illicit nature of injection drug use and associated social stigma have created substantial challenges for HIV prevention in this group. Despite these obstacles, several programmes have shown that HIV transmission in injecting drug users can be prevented, stabilised, and even reversed with needle exchange programmes. However, the HIV epidemic continues to grow in this high-risk population in some regions, particularly in eastern Europe, central Asia, and, since 2007, sub-Saharan Africa. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Salim S Abdool Karim Tags: Comment Source Type: research

[Comment] After first-line ART: towards an evidence-based SECOND-LINE
Access to antiretroviral therapy in low-income and middle-income countries has been scaled-up effectively in the past decade; however, failure of the first-line regimen is increasing. In The Lancet, the SECOND-LINE Study Group provide a high-quality evidence-based strategy for safe and effective treatment of patients in whom first-line treatment has failed. They did a randomised clinical trial to compare a WHO-recommended second-line treatment regimen—a ritonavir-boosted protease inhibitor (lopinavir) plus two or three nucleoside or nucleotide reverse transcriptase inhibitors (NtRTIs)—with a novel dual-treatment approa...
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Alessandro Soria, Andrea Gori Tags: Comment Source Type: research

[Comment] Hepatitis C treatment: interferon free or interferon freer?
Pegylated interferon alfa-2a (peginterferon) and ribavirin are the standard of care for all six genotypes of hepatitis C virus. Hepatitis C virus (HCV) does not integrate into the human genome. Thus a sustained virological response (SVR) is tantamount to virological cure and reduces the likelihood of progressive liver disease. About 45% of patients with HCV genotype-1 achieve SVR. Single nucleotide polymorphisms in the human genome affect response to interferon. However, patients with cirrhosis have lower response rates. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Geoffrey Dusheiko, Tabinda Burney Tags: Comment Source Type: research

[Comment] Public and global engagement with global health
Global health is widely regarded as being grounded in public and global engagement. But much of the process of global health is dominated by Northern institutions, expert groups, think-tanks, high-level meetings, and the like. Indeed, the exponential growth of global health in the past decade may soon turn into terminal decline unless truly global and broad-based ownership of the concept can be achieved. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Peter Friberg, Stig Wall, Yulia Blomstedt, Robert Beaglehole, Ruth Bonita, Gunhild Stordalen, Peter Byass Tags: Comment Source Type: research

[Comment] During Turkish protests, medical personnel targeted
Recent events in Turkey have alarmed the international community. The Justice and Development Party (AKP) first came to power in 2002, after being formed in 2001 by members of other existing parties that had been banned from politics for endangering Turkish secularism. It is a centre-right conservative political party, and is described in western media as being Islamist, although this is denied by most party members. The party is also the largest in Turkey. It won a landslide victory in 2002, and since then has won elections with a greater share of votes on each occasion. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Name and address supplied Tags: Comment Source Type: research

[Comment] Offline: The RCPCH—defending children's health
The Royal College of Physicians doesn't do it. Nor does the Academy of Medical Sciences. Both organisations make immensely important contributions to the strength of medicine and science in the UK. Britain would be considerably poorer without them. But neither has what the Royal College of Paediatrics and Child Health (RCPCH) has—an annual research-driven meeting over 3 days that brings together members of all ages, specialties, and interests. This year's RCPCH meeting was held in Glasgow, together with the European Paediatrics Association. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Richard Horton Tags: Comment Source Type: research

[World Report] MERS-CoV: in search of answers
In recent weeks, researchers have uncovered key molecular and clinical details about this novel virus, but fundamental questions remain about how it spreads. Anna Petherick reports. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Anna Petherick Tags: World Report Source Type: research

[World Report] Malaysia makes progress against HIV, but challenges remain
Malaysia has taken great strides in tackling HIV, but difficult issues remain for the mainly Muslim country, including the use of condoms outside of marriage. Sima Barmania reports. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Sima Barmania Tags: World Report Source Type: research

[World Report] Profile: IAVI—searching for the Achilles' heel of HIV
Taking in the picture-postcard view of southwest London rooftops from a vantage point high in the upper reaches of Chelsea and Westminster Hospital, it doesn't exactly feel like you're on one of the front lines in the battle against the HIV/AIDS pandemic. But just down the corridor, at the Human Immunology Laboratory (HIL) of the International Aids Vaccine Initiative (IAVI), researchers have been striving for over a decade to develop a weapon against the HIV virus that could finally end the pandemic: a safe, effective vaccine. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: David Holmes Tags: World Report Source Type: research

[Perspectives] Adeeba Kamarulzaman: fighting HIV/AIDS in Malaysia
(Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Priya Shetty Tags: Perspectives Source Type: research

[Perspectives] Sex, death, disease, and social change
While many things changed in South Africa's black communities after the loosening of apartheid control in the early 1990s, perhaps none were more germane to the growing HIV epidemic than the free movement of people and the new forms of socialisation that arose at this time. Back then from my veranda in a peri-urban township outside Durban, I had a front-row view of a changing youth culture. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Suzanne Leclerc-Madlala Tags: Perspectives Source Type: research

[Perspectives] Loving the alien
“One of the things that suggested to surgeons that it would be possible to insert a rigid tube down into the throat was the performances of sword swallowers”, Sarah Chaney tells me. We're standing in the North Cloisters of University College London (UCL) in front of the Foreign Bodies display that Chaney has curated. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Niall Boyce Tags: Perspectives Source Type: research

[Obituary] Timothy Grant Manchester
(Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Stephen Pincock Tags: Obituary Source Type: research

[Correspondence] Tamoxifen therapy for patients with breast cancer
Christina Davies and colleagues (March 9, p 805) show that extending tamoxifen from 5 to 10 years reduces recurrence and mortality for women with oestrogen receptor-positive breast cancer. They estimate that 10 years of treatment would nearly halve breast cancer mortality. However, this result raises the question of long-term adherence to treatment. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Laetitia Huiart, Cyril Ferdynus, Roch Giorgi Tags: Correspondence Source Type: research

[Correspondence] Tamoxifen therapy for patients with breast cancer
We read with interest the results of the ATLAS trial, and we would like to highlight some shortcomings. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Jennifer Litton, Aman Buzdar, Mariana Chavez Mac Gregor, Ana Gonzalez-Angulo, Gabriel Hortobagyi Tags: Correspondence Source Type: research

[Correspondence] Tamoxifen therapy for patients with breast cancer
The findings from the ATLAS trial demonstrate that extended use of adjuvant tamoxifen beyond 5 years is beneficial for women with oestrogen receptor (ER)-positive breast cancer. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Patrick Neven, Heikki Joenssu, Kent Osborne, Fatima Cardoso, Sybille Loibl, Sabine Linn, Aaron Goldhirsch, Olaf Ortmann, Hans Joerg Senn, Daniel F Hayes Tags: Correspondence Source Type: research

[Correspondence] Tamoxifen therapy for patients with breast cancer – Authors' reply
Key findings from trials of 5 years or 10 years of tamoxifen are summarised in the . They are remarkable. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Christina Davies, Richard Gray, Hongchao Pan, Richard Peto, for the ATLAS collaborative group Tags: Correspondence Source Type: research

[Correspondence] Autologous HSCT for systemic sclerosis
Richard Burt and colleagues (March 30, p 1116) propose from a retrospective analysis of autologous haemopoietic stem-cell transplantation (HSCT) in 90 patients with systemic sclerosis that comprehensive cardiac screening including fluid challenge improves patient selection. They ascribe the higher treatment-related mortality in the ASTIS trial (10% vs 6% in their study) to less rigorous cardiac screening, which mandated right heart catheterisation only if there was pulmonary arterial hypertension on echo. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Jacob M van Laar, Svetlana I Nihtyanova, Kamran Naraghi, Christopher P Denton, Alan Tyndall Tags: Correspondence Source Type: research

[Correspondence] Autologous HSCT for systemic sclerosis
Richard Burt and colleagues' study of treatment-related mortality of autologous haemopoietic cell transplantation in progressive autoimmune diseases is promising with an acceptable 5% treatment-related mortality, compared with 10% in the ASTIS trial. However, we believe that some issues need to be further clarified. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Ioanna Sakellari, Eleni Gavriilaki, Despoina Mallouri, Ioannis Batsis, Achilles Anagnostopoulos Tags: Correspondence Source Type: research

[Correspondence] Autologous HSCT for systemic sclerosis – Authors'reply
We thank Jacob van Laar and colleagues and Ioanna Sakellari and colleagues for their comments. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Richard K Burt, Sanjiv J Shah, James Schroeder, Maria Carolina Oliveira, Daniela A Moraes, Belinda Simoes, Zora Marjanovic, Dominique Farge Tags: Correspondence Source Type: research

[Correspondence] Addressing NCDs: is it really a global coalition?
The Lancet, in its excellent Series, acknowledged the importance of non-communicable diseases (NCDs), particularly in low-income and middle-income countries (LMICs). These Series stress, among many important points, the need for global cooperation and partnership towards addressing NCDs. However, it is surprising to observe the over-representation of researchers based in high-income countries and the limited participation of LMIC-based researchers in all four Lancet Series (); an observation that warrants open criticism and immediate pragmatic action. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Rodrigo M Carrillo-Larco, Alessandro R Demaio, J Jaime Miranda Tags: Correspondence Source Type: research

[Correspondence] Addressing NCDs: is it really a global coalition? – Authors' reply
We appreciate the positive comments by Rodrigo Carrillo-Larco and colleagues on the four Lancet Series on non-communicable diseases (NCDs). We applaud the reference to the efforts being made to encourage the inclusion of contributors from low-income and middle-income countries into major debates and to remove barriers to publishing. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Robert Beaglehole, Ruth Bonita, Richard Horton Tags: Correspondence Source Type: research

[Correspondence] Open access policy
We welcome The Lancet's stance on open access (April 6, p 1166). We note that you wish to review how you can make all publicly funded research as accessible and usable as possible. However, we also note that even with the announced changes, The Lancet will still have less free access than other key general medical journals. For example, there is free access to all research articles in The Journal of the American Medical Association (JAMA) after 6 months from 1998, in the New England Journal of Medicine after 6 months from 1990, and in The British Medical Journal immediately from 1840 onwards. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Judith R Glynn, Sara L Thomas Tags: Correspondence Source Type: research

[Correspondence] Open access policy – Authors' reply
Judith Glynn and Sara Thomas raise important questions about our current policy to offer open access publications as outlined in our recent Comment. Our announcement is only a first step in a fast evolving movement towards making publicly funded research as accessible as possible, and we are continuously reviewing our approach. However, many of our research papers—all those reporting global health research—are already routinely made free to access immediately at publication. In addition, we are launching the first open access journal within the Lancet family, The Lancet Global Health, on June 25, this year. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: The Lancet Editors Tags: Correspondence Source Type: research

[Department of Error] Department of Error
The Lancet. Salt: friend or foe? Lancet 2013;381: 1790—In this Editorial (May 25), the fifth line of the second paragraph should have stated “2300 mg sodium”. The last line of this paragraph should have stated “3400 mg sodium (about 1·5 teaspoons of salt) daily”. The fifth line of the third paragraph should have read “less than 2300 mg sodium”. The last two lines of the fourth paragraph should have read “1500–2300 mg daily sodium intake”. These corrections have been made to the online version as of June 14, 2013. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: The Lancet Tags: Department of Error Source Type: research

[Department of Error] Department of Error
The Lancet. Towards better health in China. Lancet 2013;381: 1959— In this Editorial (June 8), the following sentence in the second paragraph should have read “Chronic obstructive pulmonary disease remains one of the leading causes of death in China.” This correction has been made to the online version as of June 14, 2013. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: The Lancet Tags: Department of Error Source Type: research

[Articles] Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial
In this study, daily oral tenofovir reduced the risk of HIV infection in people who inject drugs. Pre-exposure prophylaxis with tenofovir can now be considered for use as part of an HIV prevention package for people who inject drugs. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Kachit Choopanya, Michael Martin, Pravan Suntharasamai, Udomsak Sangkum, Philip A Mock, Manoj Leethochawalit, Sithisat Chiamwongpaet, Praphan Kitisin, Pitinan Natrujirote, Somyot Kittimunkong, Rutt Chuachoowong, Roman J Gvetadze, Janet M McNicholl, Lynn A Tags: Articles Source Type: research

[Articles] Ritonavir-boosted lopinavir plus nucleoside or nucleotide reverse transcriptase inhibitors versus ritonavir-boosted lopinavir plus raltegravir for treatment of HIV-1 infection in adults with virological failure of a standard first-line ART regimen (SECOND-LINE): a randomised, open-label, non-inferiority study
The raltegravir regimen was no less efficacious than the standard of care and was safe and well tolerated. This simple NtRTI-free treatment strategy might extend the successful public health approach to management of HIV by providing simple, easy to administer, effective, safe, and tolerable second-line combination antiretroviral therapy. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: SECOND-LINE Study Group Tags: Articles Source Type: research

[Articles] Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial
Our findings suggest that sofosbuvir is well tolerated and that there is no additional benefit of extending treatment beyond 12 weeks, but these finding will have to be substantiated in phase 3 trials. These results lend support to the further assessment of a 12 week sofosbuvir regimen in a broader population of patients with chronic HCV genotype-1 infection, including those with cirrhosis. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Kris V Kowdley, Eric Lawitz, Israel Crespo, Tarek Hassanein, Mitchell N Davis, Michael DeMicco, David E Bernstein, Nezam Afdhal, John M Vierling, Stuart C Gordon, Jane K Anderson, Robert H Hyland, Hadas Dvory-Sobol, Di An, Robert G Hindes, Efsevia Albanis Tags: Articles Source Type: research

[Clinical Picture] Jaccoud's arthropathy
A 20-year-old man was referred to us for assessment of a 1 year history of dyspnoea on exertion. At the age of 9 years, he had had two episodes of migratory polyarthritis suggestive of rheumatic fever. Cardiovascular examination showed a grade III/VI pansystolic murmur at the apex (see ). We noticed he had painless, correctable deformities of his hands and feet (). He did not know his hands were deformed. His joints were enlarged but there was no evidence of active joint inflammation or functional impairment, and no subcutaneous nodules. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Ajay S Chaurasia, Jaywant M Nawale, Sandeep N Patil, Madhusudan A Yemul, Sachin M Mukhedkar, Dhirender Singh, Pranjal K Patil, Rajendra V Chavan Tags: Clinical Picture Source Type: research

[Review] Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs
Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to regimens that are both expensive and associated with toxic effects. A curative intervention will be needed to fully stop the epidemic. The failure to eradicate HIV infection during long-term antiretroviral therapy shows the intrinsic stability of the viral genome in latently infected CD4T cells and other cells, and possibly a sustained low-level viral replication. Heterogeneity in latently infected cell populations and homoeostatic proliferation of infected cells might affect the dynamics of virus production and persistence. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Christine Katlama, Steven G Deeks, Brigitte Autran, Javier Martinez-Picado, Jan van Lunzen, Christine Rouzioux, Michael Miller, Stefano Vella, Joern E Schmitz, Jeffrey Ahlers, Douglas D Richman, Rafick P Sekaly Tags: Review Source Type: research

[Health Policy] Good Health at Low Cost 25 years on: lessons for the future of health systems strengthening
In 1985, the Rockefeller Foundation published Good health at low cost to discuss why some countries or regions achieve better health and social outcomes than do others at a similar level of income and to show the role of political will and socially progressive policies. 25 years on, the Good Health at Low Cost project revisited these places but looked anew at Bangladesh, Ethiopia, Kyrgyzstan, Thailand, and the Indian state of Tamil Nadu, which have all either achieved substantial improvements in health or access to services or implemented innovative health policies relative to their neighbours. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Dina Balabanova, Anne Mills, Lesong Conteh, Baktygul Akkazieva, Hailom Banteyerga, Umakant Dash, Lucy Gilson, Andrew Harmer, Ainura Ibraimova, Ziaul Islam, Aklilu Kidanu, Tracey P Koehlmoos, Supon Limwattananon, VR Muraleedharan, Gulgun Murzalieva, Benjam Tags: Health Policy Source Type: research

[Case Report] Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China
In February, 2013, a novel avian influenza A H7N9 virus emerged in east China and quickly spread to other areas. By May 27, 130 human infections had been confirmed, with 37 deaths. Transmission can occur through direct or close contact with poultry or through exposure to environments that are contaminated with poultry. No human-to-human transmission has been reported. Co-infection of viruses in human beings, birds, or other animals provides the possibility for the emergence of a new reassortant virus. (Source: LANCET)
Source: LANCET - June 15, 2013 Category: Journals (General) Authors: Yefei Zhu, Xian Qi, Lunbiao Cui, Minghao Zhou, Hua Wang Tags: Case Report Source Type: research

Effects of multiple chronic conditions on health care costs: an analysis based on an advanced tree-based regression model
Conclusions: Irrespective of any combination and number of co-occurring diseases, PD and CI appear to be most influential on total health care costs in elderly patients with MM, and only a limited number of factors significantly influenced cost.Trial registration: Current Controlled Trials ISRCTN89818205 (Source: BMC Health Services Research)
Source: BMC Health Services Research - June 15, 2013 Category: Journals (General) Authors: Hans-Helmut KönigHanna LeichtHorst BickelAngela FuchsJochen GensichenWolfgang MaierKarola MergenthalSteffi Riedel-HellerIngmar SchäferGerhard SchönSiegfried WeyererBirgitt WieseHendrik van den BusscheMartin SchererMatthias Eckardt Source Type: research

Evaluation of an integrated system for classification, assessment and comparison of services for long-term care in Europe: the eDESDE-LTC study
Conclusion: DESDE-LTC contributes to establishing a common terminology, taxonomy and coding of LTC services in a European context, and a standard procedure for data collection and international comparison. (Source: BMC Health Services Research)
Source: BMC Health Services Research - June 15, 2013 Category: Journals (General) Authors: Luis Salvador-CarullaJavier Alvarez-GalvezCristina RomeroMencia Gutiérrez-ColosíaGermain WeberDavid McDaidHristo DimitrovLilijana SprahBirgitte KalsethGiuseppe TibaldiJose Salinas-PerezCarolina Lagares-FrancoMaria Romá-FerriSonia Johnson Source Type: research

Feasibility, reliability and validity of a questionnaire on healthcare consumption and productivity loss in patients with a psychiatric disorder (TiC-P)
Conclusions: The results indicate that the TiC-P is a feasible and reliable instrument for collecting data on medical consumption and productivity losses in patients with mild to moderate mental health problems. Additionally, the construct validity of questions related to contacts with psychotherapist and long-term absence from work was satisfactory. (Source: BMC Health Services Research)
Source: BMC Health Services Research - June 15, 2013 Category: Journals (General) Authors: Clazien BouwmansKim De JongReinier TimmanMoniek VlasveldChristina Van der Feltz-CornelisSiok TanLeona Hakkaart-van Roijen Source Type: research

Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing
Conclusions: Extensive sequence and structure comparisons reveal unexpectedly broad presence of the HEPN domain in an enormous variety of defense and stress response systems across the tree of life. In addition, HEPN domains have been recruited to perform essential functions, in particular in eukaryotic rRNA processing. These findings are expected to stimulate experiments that could shed light on diverse cellular processes across the three domains of life.Reviewers: This article was reviewed by Martijn Huynen, Igor Zhulin and Nick Grishin (Source: BioMed Central)
Source: BioMed Central - June 15, 2013 Category: Journals (General) Authors: Vivek AnantharamanKira S MakarovaA Maxwell BurroughsEugene V KooninL Aravind Source Type: research

Disparities in the use of antenatal care service in Ethiopia over a period of fifteen years
Conclusions: The wide inequities between urban and rural areas, across economic and educational strata in the use of antenatal care highlight the need to put more resources to poor households, rural areas, and disadvantage regions. We suggest further study to understand additional factors for the deep unmet need in rural areas and some regions of Ethiopia. (Source: BioMed Central)
Source: BioMed Central - June 15, 2013 Category: Journals (General) Authors: Elias Ali YesufRonit Calderon-Margalit Source Type: research

Seroepidemiological study of ovine toxoplasmosis in East and West Shewa Zones of Oromia Regional State, Central Ethiopia
Background: Toxoplasmosis is a globally distributed zoonosis. Consumption of raw or undercooked meat, which is among the main risk factors for acquiring human infection, is a popular tradition in Ethiopia. However, studies on toxoplasmosis in food animals used for human consumption in Ethiopia are very scarce. Thus, the objectives of the present study were to estimate the seroprevalence and the risk factors of T. gondii infection in sheep in Ambo, Ada'a-Liben and Fentale districts of Central Ethiopia. Sera from 1130 sheep were analyzed for Toxoplasma gondii specific IgG antibodies using an indirect enzyme linked immunosorb...
Source: BioMed Central - June 15, 2013 Category: Journals (General) Authors: Endrias Zewdu GebremedhinAbebe AgonafirTesfaye Sisay TessemaGetachew TilahunGirmay MedhinMaria VitaleVincenzo Di MarcoEric CoxJozef VercruyssePierre Dorny Source Type: research

ID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastoma
Conclusions: High ID3 expression is associated with medullolbastoma seeding and is a poor prognostic factor, especially in patients with Group 4 tumors. ID3 may represent the metastatic/ aggressive phenotype of a subgroup of medulloblastoma. (Source: BioMed Central)
Source: BioMed Central - June 15, 2013 Category: Journals (General) Authors: Ji Hoon PhiSeung Ah ChoiSang-Hee LimJoongyub LeeKyu-Chang WangSung-Hye ParkSeung-Ki Kim Source Type: research

The University of Texas Houston Stroke Registry (UTHSR): implementation of enhanced data quality assurance procedures improves data quality
Conclusions: Establishment of a rigorous data quality assurance for our UTHSR has helped to improve the validity of data. We observed an excellent IRR between the two abstractors. We recommend training of chart abstractors and systematic assessment of IRR between abstractors and validity of the abstracted data in stroke registries. (Source: BioMed Central)
Source: BioMed Central - June 15, 2013 Category: Journals (General) Authors: Mohammad H RahbarNicole R GonzalesManouchehr Ardjomand-HessabiAmirali TahananMelvin R SlineHui PengRenganayaki PandurenganFarhaan S VahidyJessica D TanksleyAyodeji A DelanoRene M MalazarteEllie E ChoiSean I SavitzJames C Grotta Source Type: research