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The furanosteroid viridiol
The asymmetric unit of the title compound, C20H18O6 (systematic name: 1β,3β-dihydroxy-2β-methoxyfuro[4′,3′,2′:4,5,6]-18-norandrosta-8,11,13-triene-7,17-dione), a dihydro derivative of the fungal steroid viridin, contains two molecules with similar conformations. The rings bearing the hydroxy groups adopt boat conformations. The absolute structure was assigned based on the known chirality of a precursor compound. In the crystal, molecules are linked by O—H...O hydrogen bonds, generating a three-dimensional network and weak C—H...O interactions consolidate the packing.
Source: Acta Crystallographica Section E - March 2, 2013 Category: Chemistry Authors: Andersson, P.F.Broberg, A.Lundberg, D. Tags: organic compounds Source Type: research

(1′S,12′R,13′S,17′S)-15′,15′-Dimethyl-1,2-dihydro-11′,14′,16′,18′-tetraoxa-7′-azaspiro[indole-3,8′-pentacyclo[10.6.0.02,9.03,7.013,17]octadecane]-2,10′-dione
In the title compound, C22H24N2O6, the indole ring has a twist conformation and the tetrahydro-2H-pyran-2-one ring a half-chair conformation. One of the pyrrolidine rings adopts an envelope conformation on the N atom, while the other has a twist conformation; the `butterfly' angle between their mean planes is 62.98 (11)°. The dioxolane ring adopts a twist conformation and the tetrahydrofuran ring has an envelope conformation on the C atom in the fused tetrahydro-2H-pyran-2-one ring adjacent to the O atom of the tetrahydrofuran ring. The `butterfly' angle between the mean planes of these two five-membered rings is 69.14�...
Source: Acta Crystallographica Section E - March 2, 2013 Category: Chemistry Authors: Sabari, V.Ponnusamy, R.Prasanna, R.Raghunathan, R.Aravindhan, S. Tags: organic compounds Source Type: research

3-(4-Chlorophenyl)-5-(4-ethoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide ethanol monosolvate
The asymmetric unit of the title compound, C18H18ClN3OS·C2H5OH, comprises a pyrazoline derivative and an ethanol solvent molecule. In the molecule of the pyrazoline derivative, the pyrazole ring adopts an envelope conformation with the C atom bearing the ethoxyphenyl substituent as the flap. The dihedral angle between the benzene rings is 74.22 (7)°. The ethoxy group is coplanar with the attached benzene ring [C—O—C—Cmethyl = 175.50 (11)° and r.m.s. deviation = 0.0459 (1) Å for the nine non-H atoms]. In the crystal, the pyrazoline molecules are linked by N—H...Oethoxy hydrogen bonds into chains along th...
Source: Acta Crystallographica Section E - March 2, 2013 Category: Chemistry Authors: Quah, C.K.Fun, H.-K.Suwunwong, T.Boonnak, N.Chantrapromma, S. Tags: organic compounds Source Type: research

2-Amino-4-(4-chlorophenyl)-4H-chromeno[8,7-b]pyridine-3-carbonitrile
The asymmetric unit of the title compound, C19H12ClN3O, contains two molecules with similar conformations. The 14 non-H atoms comprising the 4H-chromeno[8,7-b]pyridine residue are essentially coplanar (r.m.s. deviations = 0.037 and 0.042 Å for the two molecules) and the main difference between them is seen in the twist about the bond linking the main residue to the attached chlorobenzene rings [dihedral angles = 79.01 (12) and 76.22 (11)° for the two molecules]. Zigzag supramolecular chains along the a-axis direction mediated by amino–pyridine N—H...N hydrogen bonds feature in the crystal packing; these are con...
Source: Acta Crystallographica Section E - March 2, 2013 Category: Chemistry Authors: Amr, A.E.-G.E.El-Agrody, A.M.Sabry, N.M.Ng, S.W.Tiekink, E.R.T. Tags: organic compounds Source Type: research

Poly[[(μ4-1,3,5-triamino-1,3,5-trideoxy-cis-inositol)sodium] bromide]
In the structure of the title compound, {[Na(C6H15N3O3)]Br}n, the sodium cation and the bromide anion are both located on threefold rotation axes. The sodium cation is bonded to the three hydroxy groups of one 1,3,5-triamino-1,3,5-trideoxy-cis-inositol (taci) ligand, with the taci ligand residing around the same threefold rotation axis as the sodium ion. The coordination sphere of the sodium ion is completed by three amino groups of three neighbouring taci molecules. Hence, this type of coordination constitutes a three-dimensional open framework with channels along the c axis which are filled with the bromide counter-anion...
Source: Acta Crystallographica Section E - March 2, 2013 Category: Chemistry Authors: Reiss, G.J.Hegetschweiler, K. Tags: metal-organic compounds Source Type: research

Bis{1-[(1H-benzimidazol-1-yl)methyl]-1H-imidazole-κN3}bis(3,5-dicarboxybenzoato-κ2O1,O1′)nickel(II) octahydrate
In the title complex, [Ni(C9H5O6)2(C11H10N4)2]·8H2O, the NiII ion exhibits site symmetry 2. It has a distorted octahedral coordination defined by two N atoms from two symmetry-related 1-[(1H-benzimidazol-1-yl)methyl]-1H-imidazole ligands and four O atoms from two symmetry-related 3,5-dicarboxybenzoate anions. In the crystal, the complex molecules and solvent water molecules are linked via O—H...O, O—H...N and N—H...O hydrogen bonds, forming a three-dimensional structure. There are also a number of C—H...O interactions present.
Source: Acta Crystallographica Section E - March 2, 2013 Category: Chemistry Authors: Jia, Y.-Y.Fan, J.-J.Yin, X.-G.Zhao, W.-L. Tags: metal-organic compounds Source Type: research

[(2R,3S)-Butane-1,2,3,4-tetraol-κ3O1,O2,O3](ethanol-κO)tris(nitrato-κ2O,O′)samarium(III)
The title SmIII–erythritol complex, [Sm(NO3)3(C2H6O)(C4H10O4)], is isotypic with its Nd, Eu, Y, Gd, Tb and Ho analogues. The SmIII cation exhibits a coordination number of ten and is chelated by a tridentate erythritol ligand and three bidentate nitrate anions. It is additionally coordinated by an O atom of an ethanol molecule, completing an irregular coordination sphere. The Sm—O bond lengths range from 2.416 (2) to 2.611 (2) Å. In the crystal, extensive O—H...O hydrogen bonding involving all hydroxy groups and some of the nitrate O atoms links the molecules into a three-dimensional network.
Source: Acta Crystallographica Section E - March 2, 2013 Category: Chemistry Authors: Xue, J.-H.Hua, X.-H.Yang, L.-M.Xu, Y.-Z.Wu, J.-G. Tags: metal-organic compounds Source Type: research

Bis[1,2-bis(ethoxycarbonyl)ethene-1,2-dithiolato-κ2S,S′]bis(η5-pentamethylcyclopentadienyl)tetra-μ3-sulfido-diiron(IV)diiron(III)(3 Fe—Fe)
The title compound, [Fe4(C10H15)2(C8H10O4S2)2S4], contains a twisted Fe4S4 cubane-like core. A twofold rotation axis passes through the Fe4S4 core, completing the coordination of the four Fe atoms with two pentamethylcyclopentadienyl ligands and two chelating dithiolate ligands. There are three short Fe—Fe and three long Fe...Fe contacts in the Fe4S4 core, suggesting bonding and non-bonding interactions, respectively. The Fe—S bonds in the Fe4S4 core range from 2.1523 (5) to 2.2667 (6) Å and are somewhat longer than the Fe—S bonds involving the dithiolate ligand.
Source: Acta Crystallographica Section E - March 2, 2013 Category: Chemistry Authors: Ito, S.Hisamichi, N.Takase, T.Inomata, S. Tags: metal-organic compounds Source Type: research

Bromido(1,4,7,10,13-pentaazacyclohexadecane)cobalt(III) dibromide dihydrate
The title salt, [CoBr(C11H27N5)]Br2·2H2O, contains a complex cation with mirror symmetry and two Br− counter-anions that are likewise located on the mirror plane. The central CoIII atom of the complex cation has one Br− ion in an axial position, one N atom of the pentadentate macrocyclic ligand in the other axial position and four N atoms of the ligand in equatorial positions, defining a distorted octahedral coordination geometry. The macrocyclic ligand is coordinated to the CoIII atom within a 5, 6, 5 arrangement of chelate rings in the equatorial plane of the four N atoms. Due to symmetry, the configuration of the c...
Source: Acta Crystallographica Section E - March 2, 2013 Category: Chemistry Authors: Kurisaki, T.Hamano, M.Wakita, H. Tags: metal-organic compounds Source Type: research

Intrarenal resistance index for the assessment of acute renal injury in a rat liver transplantation model
Conclusions: The intrarenal RI increased significantly during the anhepatic stage, and decreased significantly early after the reperfusion. Intrarenal RI was unable to assess renal function in a rat liver transplantation model.
Source: BMC Nephrology - March 2, 2013 Category: Urology & Nephrology Authors: Hai-Ying KongFen ChenYong HeLin-Jiao WuLi-Qing WangSheng-Mei ZhuShu-Sen Zheng Source Type: research

Planning and adjustments for the control of reach extent in a virtual environment
Conclusions: The VE did not impact movement planning or subsequent compensatory adjustments for the control of reach extent when directly compared to an analogous RWE. An immersive VE is a valid environment for the study of unconstrained reach actions.
Source: Journal of NeuroEngineering and Rehabilitation - March 2, 2013 Category: Rehabilitation Authors: Jill StewartJames GordonCarolee Winstein Source Type: research

Reduction of the domino effect in osteoporotic vertebral compression fractures through short-segment fixation with intravertebral expandable pillars compared to percutaneous kyphoplasty: a case control study
Conclusions: In older individuals with vertebral compression fractures, kyphoplasty restored and maintained the collapsed vertebral body with less kyphotic deformity than that induced by short-segment fixation with I-VEP. Short-segment fixation with I-VEP was more effective in maintaining the integrity of adjacent segments, which prevented the domino effect often observed in patients with osteoporotic kyphotic spines.
Source: BMC Musculoskeletal Disorders - March 2, 2013 Category: Orthopaedics Authors: Jui-Yang HsiehChung-Ding WuTing-Ming WangHsuan-Yu ChenChui-Jia FarnPo-Quang Chen Source Type: research

Association of menstrual phase with smoking behavior, mood and menstrual phase-associated symptoms among young Japanese woman smokers
Conclusions: In the menstrual and luteal phases, young Japanese women smokers increased their amount of smoking and suffered from greater craving for smoking, depressiveness and menstrual phase-associated symptoms. The amount of smoking was correlated with these symptoms, but their cause-effect relationship has not been determined yet.
Source: BMC Women's Health - Latest articles - March 2, 2013 Category: OBGYN Authors: Hiroko SakaiKazutomo Ohashi Source Type: research

Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial
DiscussionThe HERO trial is designed to examine whether hydroxychloroquine is an effective analgesic treatment for OA and whether it provides any long-term structural benefit. The ultrasound substudy will address whether baseline synovitis is a predictor of therapeutic response. This will potentially provide a new treatment for OA, which could be of particular use in the primary care setting.Trial registration: ISRCTN91859104
Source: Trials - March 2, 2013 Category: Journals (General) Authors: Sarah KingsburyPuvan TharmanathanJoy AdamsonNigel ArdenFraser BirrellSarah CockayneJohn DicksonMichael DohertyKrysia DziedzicAndrew GraingerCatherine HewittTerence O¿NeillDavid ScottTonia VincentRichard WakefieldFiona WattDavid TorgersonPhilip Conaghan Source Type: research

Effects of ectopic HER-2/neu gene expression on the COX-2/PGE2/P450arom signaling pathway in endometrial carcinoma cells: HER-2/neu gene expression in endometrial carcinoma cells
Conclusion: HER-2/neu induced the improvement of autocrine estrogen in endometrial carcinoma cell through triggering the COX-2/P450arom signal.
Source: BioMed Central - March 2, 2013 Category: Journals (General) Authors: Shu LiXiaoXin MaLi MaCuicui WangYuanQi HeZhiJuan Yu Source Type: research

Cross recurrence quantification analysis of precision grip following peripheral median nerve block
Conclusions: Nerve block caused more deterministic structures in force, torque and center of pressure when the thumb interacted with the index finger. A compensatory mechanism may be responsible for this change. Phase synchronization between the opposite normal forces exerted by the thumb and index finger would be an essential dynamical principle for a precision grip. The nerve block resulted in an increased interdigit phase delay and increased probability that the thumb leads the index finger. The CRQA provides an effective tool to examine interdigit coordination during precision grip and has the potential for clinical ev...
Source: BioMed Central - March 2, 2013 Category: Journals (General) Authors: Ke LiZong-Ming Li Source Type: research

Breast reconstruction and post-mastectomy radiation practice
Conclusions: Great variation in practice is evident from our study of radiation treatment for breast cancer patients with reconstruction. Further research on the impact and delivery of radiation to a reconstructed breast may validate some of the observed practices, highlight the variability in treatment practice, and help create a treatment consensus.
Source: BioMed Central - March 2, 2013 Category: Journals (General) Authors: Susie A ChenCrispin HileyDana NickleachJanjira PetsuksiriFundagul AndicOliver RiestererJeffrey M SwitchenkoMylin A Torres Source Type: research

Reviewer Acknowledgement 2012
Contributing reviewersThe editors of BMC Pulmonary Medicine would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).
Source: BioMed Central - March 2, 2013 Category: Journals (General) Authors: Tim Shipley Source Type: research

Cost‐Effectiveness of Additional Catheter‐Directed Thrombolysis for Deep Vein Thrombosis
ConclusionsAdditional CDT is likely to be a cost‐effective alternative to standard treatment for patients with high proximal DVT and low risk of bleeding.© 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - March 2, 2013 Category: Hematology Authors: Tone Enden, Stephen Resch, Craig White, Hilde Skuterud Wik, Nils Einar Kløw, Per Morten Sandset Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Recommendations for thromboprophylaxis in the 2012 focused update of the ESC guidelines on atrial fibrillation: A commentary
The objective of this article is to provide a commentary on the recommendations for stroke prevention from the 2012 focused update of the European Society of Cardiology guidelines on the management of atrial fibrillation and the evidence (or lack of it) supporting these recommendations. These guidelines strongly advocate a major clinical practice shift towards initially focusing on the identification of ‘truly low risk’ patients who do not need any antithrombotic therapy. After this initial decision‐making step, effective stroke prevention – that is, oral anticoagulation therapy (whether as well controlled adjusted...
Source: Journal of Thrombosis and Haemostasis - March 2, 2013 Category: Hematology Authors: Gregory Y H Lip Tags: Review Article Source Type: research

Anticoagulant therapy for venous thromboembolism during pregnancy: a systematic review and a meta‐analysis of the literature: a reply to a rebuttal
The problem of neuraxial analgesia in pregnant patients anticoagulated for an acute episode of venous thromboembolism is undoubtedly important. Regrettably, among studies selected for our meta‐analysis, information about epidural anesthesiology were scarce. In only two papers the authors described the protocol used for epidural anaesthesia: regional anesthesia was avoided until at least 12 hours after the least dose of low molecular weight heparin (LMWH), that in one study was reduced to a prophylactic dose on the day prior to induction of labour; LMWH was subsequently re‐administrated after three or four hours after c...
Source: Journal of Thrombosis and Haemostasis - March 2, 2013 Category: Hematology Authors: Erica Romualdi, Francesco Dentali, Alessandro Squizzato, Walter Ageno Tags: Letter ‐ Reply to Rebuttal Source Type: research

Microscopic polyangiitis complicated with ileal involvement detected by double-balloon endoscopy: a case report
Conclusion: The cause of gastrointestinal involvement in microscopic polyangiitis is ischemia due to vasculitis. It is difficult to diagnose small-vessel vasculitis by endoscopic biopsy. Although histological evidence of microscopic polyangiitis is important, the treatment should not be delayed by repeating the biopsy, because such delay can result in adverse sequelae.This case report shows that microscopic polyangiitis should be considered as a differential diagnosis when small intestinal changes like those in the present case are observed by endoscopy.
Source: BMC Gastroenterology - March 2, 2013 Category: Gastroenterology Authors: Masashi FukushimaSatoko InoueYuichiro OnoYoshitaka TamakiHajime YoshimuraYukihiro ImaiTetsuro Inokuma Source Type: research

Antioxidant and antiproliferative activities of Abrus precatorius leaf extracts - an in vitro study
Conclusion: This work provides a scientific support for the high antioxidant and antiproliferative activity of this plant and thus it may find potential applications in the treatment of the diseases caused by ROS. Further studies are needed to confirm in vivo anti-tumorgenicity and subsequent chemical characterization of the active molecule(s).
Source: BMC Complementary and Alternative Medicine - March 2, 2013 Category: Complementary Medicine Authors: Mir GulFarhan AhmadAnand KondapiInsaf QureshiIrfan Ghazi Source Type: research

Efficacy of modified LiuJunZi decoction on functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a randomized controlled trial
Conclusions: CHM modified LiuJunZi decoction appears to offer symptomatic improvement in patients with FD of spleen-deficiency and qi-stagnation syndrome.Trial registration: Chinese Clinical Trial Registry (ChiCTR): ChiCTR-TRC-10001074
Source: BMC Complementary and Alternative Medicine - March 2, 2013 Category: Complementary Medicine Authors: Shengsheng ZhangLuqing ZhaoHongbing WangChuijie WangSuiping HuangHong ShenWei WeiLin TaoTao Zhou Source Type: research

Clinicopathological characteristics and prognostic factors in young patients after hepatectomy for hepatocellular carcinoma
Conclusions: In younger patients, survival appeared to be primarily affected by liver function, while recurrence was affected by tumor factors. Young patients with hepatocellular carcinoma should be aggressively treated with hepatectomy due to their good pre-surgical liver function.
Source: World Journal of Surgical Oncology - March 2, 2013 Category: Cancer & Oncology Authors: Shingo ShimadaToshiya KamiyamaHideki YokooKenji WakayamaYosuke TsurugaTatsuhiko KakisakaHirofumi KamachiAkinobu Taketomi Source Type: research

Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer
Conclusion: These data suggest that although ABT-737 can induce autophagy in SCLC, autophagic inhibition by choroquine does not markedly alter in vivo response to ABT-737 in relevant preclinical models, arguing against this as a treatment strategy for SCLC.
Source: Molecular Cancer - March 2, 2013 Category: Cancer & Oncology Authors: Rebekah ZinnEric GardnerIrina DobromilskayaSara MurphyLuigi MarchionniChristine HannCharles Rudin Source Type: research

Perceived risks and benefits of cigarette smoking among Nepalese adolescents: a population-based cross-sectional study
Conclusion: To discourage or prevent adolescents from initiating smoking, future intervention programs should focus on communicating not only the health risks but also the social and addiction risks as well as counteract the social benefits of smoking.
Source: BMC Public Health - Latest articles - March 2, 2013 Category: Consumer Health News Authors: Umesh AryalMax PetzoldAlexandra Krettek Source Type: research

Prevalence of sexual, physical and emotional abuse in the Norwegian Mother and Child Cohort Study
Conclusion: The reported prevalence of any lifetime abuse was substantial in our low-risk pregnant population. Antenatal care is an opportunity for clinicians to ask about experiences of abuse and identify those at risk.
Source: BMC Public Health - Latest articles - March 2, 2013 Category: Consumer Health News Authors: Marie SørbøHilde GrimstadJohan BjørngaardBerit ScheiMirjam Lukasse Source Type: research

Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-kappaB and Nrf2 in the duodenal mucosa of pigs
Conclusions: This study shows that dietary supplementation of a polyphenol rich GSGME suppresses the activity of NF-kappaB in the duodenal mucosa of pigs and thus might provide a useful dietary strategy to inhibit inflammation in the gut frequently occurring in pigs. Feeding GSGME did not influence vitamin E status and the antioxidant system of the pigs but improved the gain:feed ratio. In overall, the study suggests that polyphenol-rich plant extracts such GSGME could be useful feed supplements in pig nutrition, in order to maintain animal health and improve performance.
Source: Acta Veterinaria Scandinavica - March 2, 2013 Category: Veterinary Research Authors: Denise GessnerAnja FieselErika MostJennifer DingesGaiping WenRobert RingseisKlaus Eder Source Type: research

MethylPCA: a toolkit to control for confounders in methylome-wide association studies
Conclusions: MethylPCA provides users a convenient tool to perform MWAS. The software effectively handles the challenge in memory and speed to perform tasks that would be impossible to accomplish using existing software when millions of sites are interrogated with the sample sizes required for MWAS.
Source: BMC Bioinformatics - Latest articles - March 2, 2013 Category: Bioinformatics Authors: Wenan ChenGuimin GaoSrilaxmi NerellaChristina HultmanPatrik MagnussonPatrick SullivanKarolina AbergEdwin van den Oord Source Type: research

virtualArray: a R/bioconductor package to merge raw data from different microarray platforms
Conclusions: Using this software package, researchers can easily integrate their own microarray data with data from public repositories or other sources that are based on different microarray chip types. Using the default approach a robust and up-to-date batch effect correction technique is applied to the data.
Source: BMC Bioinformatics - Latest articles - March 2, 2013 Category: Bioinformatics Authors: Andreas HeiderRüdiger Alt Source Type: research

Minimal Plus One Point Designs for Testing Lack of Fit for Some Sigmoid Curve Models
Source: Journal of Biopharmaceutical Statistics - March 2, 2013 Category: Statistics Authors: Su, YingRaghavarao, Damaraju Source Type: research

In memoriam Dr Heimo Nielsen
Source: Isotopes in Environmental Health Studies - March 2, 2013 Category: Environmental Health Authors: Bottcher, Michael E.Hoefs, Jochen Source Type: research

Contents
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Source: Aviation, Space, and Environmental Medicine - March 2, 2013 Category: Sports Medicine Tags: CONTENTS Source Type: research

Transcultural Psychiatry Made Simple—Asynchronous Telepsychiatry as an Approach to Providing Culturally Relevant Care
Telemedicine and e-Health , Vol. 0, No. 0.
Source: Telemedicine and e-Health - March 1, 2013 Category: Information Technology Tags: article Source Type: research

Effect of Dietary Monosaccharides on Pseudomonas aeruginosa Virulence
Surgical Infections , Vol. 0, No. 0.
Source: Surgical Infections - March 1, 2013 Category: Surgery Tags: article Source Type: research

Galanin Promotes Neuronal Differentiation in Murine Subventricular Zone Cell Cultures
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - March 1, 2013 Category: Stem Cells Tags: article Source Type: research

Necessity of Both Waist Circumference and Waist-to-Height Ratio for Better Evaluation of Central Obesity
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0.
Source: Metabolic Syndrome and Related Disorders - March 1, 2013 Category: Endocrinology Tags: article Source Type: research

Therapeutic Efficacy of Endoscopic Retrograde Cholangiopancreatography Among Pregnant Women with Severe Acute Biliary Pancreatitis
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0.
Source: Journal of Laparoendoscopic - March 1, 2013 Category: Surgery Tags: article Source Type: research

Cigarette Smoke Condensate Extracts Induce IL-1-Beta Production from Rheumatoid Arthritis Patient-Derived Synoviocytes, But Not Osteoarthritis Patient-Derived Synoviocytes, Through Aryl Hydrocarbon Receptor-Dependent NF-Kappa-B Activation and Novel NF-Kappa-B Sites
Journal of Interferon & Cytokine Research , Vol. 0, No. 0.
Source: Journal of Interferon - March 1, 2013 Category: Research Tags: article Source Type: research

Chimeric NKG2D CAR-Expressing T Cell-Mediated Attack of Human Ovarian Cancer Is Enhanced by Histone Deacetylase Inhibition
Human Gene Therapy , Vol. 0, No. 0.
Source: Human Gene Therapy - March 1, 2013 Category: Genetics & Stem Cells Tags: article Source Type: research

Metformin Synergistically Enhances Antitumor Activity of Histone Deacetylase Inhibitor Trichostatin A Against Osteosarcoma Cell Line
DNA and Cell Biology , Vol. 0, No. 0.
Source: DNA and Cell Biology - March 1, 2013 Category: Cytology Tags: article Source Type: research

Standardization of Self-Monitoring of Blood Glucose and Continuous Glucose Monitoring Reporting
Diabetes Technology & Therapeutics , Vol. 0, No. 0.
Source: Diabetes Technology - March 1, 2013 Category: Endocrinology Tags: article Source Type: research

Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets
Antioxidants & Redox Signaling , Vol. 0, No. 0.
Source: Antioxidants and Redox Signaling - March 1, 2013 Category: Research Tags: article Source Type: research

Current Concepts in Hip Arthroplasty Imaging: Metal-on-Metal Prostheses, Their Complications, and Imaging Strategies
Hip arthroplasty is a common and very successful procedure used to treat a variety of hip problems, the most frequent of which is osteoarthritis. Early attempts at hip arthroplasty used components composed of various materials, including ivory, soft tissues, and glass. The first metal-on-metal prostheses were trialed in the 1930s, although these devices were associated with unacceptably high rates of failure. Improvements in metal-on-metal design were carried out by McKee in 1953 with incorporation of a cobalt-chrome socket. These metal-on-metal devices had reasonable survival rates, although interest in such designs waned...
Source: Seminars in Roentgenology - March 1, 2013 Category: Radiology Authors: Joseph M. Bestic, Thomas H. Berquist Source Type: research

Musculoskeletal Ultrasonography: Starting Your Practice
The following represents the perspectives of 3 radiologists who have started or grown a musculoskeletal ultrasonography (MSK US) practice at 3 different institutions. The first is by Corrie Yablon, MD, who describes her experiences while at Beth Israel Deaconess Medical Center in Boston, MA. The second is by Kenneth S. Lee, MD, who shares his experience from the University of Wisconsin in Madison, WI. The third is by Jon A. Jacobson, MD, who provides insight from his past 14 years at the University of Michigan in Ann Arbor, MI.
Source: Seminars in Roentgenology - March 1, 2013 Category: Radiology Authors: Corrie M. Yablon, Kenneth S. Lee, Jon A. Jacobson Source Type: research

Femoral Acetabular Impingement
Femoral acetabular impingement (FAI) is a clinical term used to describe abnormal contact between the femoral head and the acetabular labrum during normal or athletic activity.
Source: Seminars in Roentgenology - March 1, 2013 Category: Radiology Authors: Daniel Hendry, Eric England, Keith Kenter, Robert D. Wissman Source Type: research

Cartilage Imaging: A Review of Current Concepts and Emerging Technologies
The evaluation of articular cartilage using advanced imaging techniques has become a focus of intensive research with numerous advancements in recent years. Cartilage damage may occur as the result of an acute injury or as a chronic degenerative process as in osteoarthritis. Acute injuries affecting articular cartilage are common in young athletes. In skeletally immature patients, chondral injuries are more prevalent than meniscal or cruciate ligament injuries. Chondral injuries can be classified into 3 basic patterns: (1) those that cause chondral, and possibly subchondral bone, damage but without disruption of the articu...
Source: Seminars in Roentgenology - March 1, 2013 Category: Radiology Authors: Alan D. Rogers, Jason E. Payne, Joseph S. Yu Source Type: research

Volumetric Magnetic Resonance Imaging of the Musculoskeletal System
Magnetic resonance imaging (MRI), with its excellent tissue contrast, high spatial resolution, and multiplanar capability, has become the modality of choice in assessing joint pain. Currently, the majority of magnetic resonance protocols used by institutions rely on 2-dimensional (2D) multislice acquisitions acquired in various planes. These sequences demonstrate excellent soft-tissue contrast and high in-plane spatial resolution as well as high diagnostic accuracy, particularly when evaluating for internal derangement. However, relatively thick slices, and interslice gaps, lead to volume averaging, which can obscure patho...
Source: Seminars in Roentgenology - March 1, 2013 Category: Radiology Authors: Humberto Rosas, Richard Kijowski Source Type: research

Musculoskeletal Computed Tomography: Current Technology and Clinical Applications
This article reviews the current state of CT, first highlighting several technologic advancements in scanner performance and second discussing current clinical musculoskeletal applications. CT has distinct advantages and inherent limitations in the assessment of bones, joints, and soft tissues; both need to be considered when choosing CT for a particular imaging task. This article provides a framework for understanding current CT technology and how it can be applied to a variety of musculoskeletal applications.
Source: Seminars in Roentgenology - March 1, 2013 Category: Radiology Authors: Trenton D. Roth, Kenneth A. Buckwalter, Robert H. Choplin Source Type: research