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Experiences of health care providers with integrated HIV and reproductive health services in Kenya: a qualitative study
Conclusions: The success of integration primarily depends on the performance of service providers which, in turn, depends on a whole range of facilitative organisational factors. The central Ministry of Health should create a coherent policy environment, spearhead strategic planning and ensure availability of resources for implementation at lower levels of the health system. Health facility staffing norms, technical support, cost-sharing policies, clinical reporting procedures, salary and incentive schemes, clinical supply chains, and resourcing of health facility physical space upgrades, all need attention. Yet, despite t...
Source: BMC Health Services Research - January 11, 2013 Category: Journals (General) Authors: Richard MutemwaSusannah MayhewManuela ColombiniJoanna BuszaJackline KivunagaCharity Ndwiga Source Type: research

Commentary: Why we should report results from clinical trial pilot studies
Should clinical trial pilot studies be reported? Thebane, Ma, Chu, et al. argue in their discussion of the conduct of pilot studies, that they should be published.1 Others, such as the editorialist for The Diabetes Educator, take a more cautious approach to publishing pilot studies.2 I agree with those who advocate publication. I might also note that an April 9, 2012 search of "randomized clinical trial pilot studies" in PubMed contained almost 10,000 citations. Although some of these may not reflect individual pilot studies, there may, though, be many more (without "randomized" in the search term, the number is over 20,000).
Source: Trials - January 11, 2013 Category: Journals (General) Authors: Lawrence Friedman Source Type: research

Novel biaxial tensile test for studying aortic failure phenomena at a microscopic level
Background: An aortic aneurysm is a local dilation of the aorta, which tends to expand and often results in a fatal rupture. Although larger aneurysms have a greater risk of rupture, some small aneurysms also rupture. Since the mechanism of aortic rupture is not well understood, clarification of the microstructure influencing the failure to rupture is important. Since aortic tissues are stretched biaxially in vivo, we developed a technique to microscopically observe the failure of an aortic rupture during biaxial stretch. Methods: A thinly sliced porcine thoracic aortic specimen was adhered to a circular frame and pushed o...
Source: BioMed Central - January 11, 2013 Category: Journals (General) Authors: Shukei SugitaTakeo Matsumoto Source Type: research

RACK1 is involved in endothelial barrier regulation via its two novel interacting partners
Conclusions: Transient parallel linkage of TIMAP and farnesyl transferase to RACK1 could ensure prenylation and transport of TIMAP to the plasma membrane where it may attend in maintaining the endothelial barrier as a phosphatase regulator.
Source: BioMed Central - January 11, 2013 Category: Journals (General) Authors: Anita BoratkóPál GergelyCsilla Csortos Source Type: research

DNMT3A mutations and clinical features in Chinese patients with acute myeloid leukemia
Mutations in DNA methyltransferase 3A (DNMT3A) gene were recently demonstrated in acute myeloid leukemia(AML). Approximately 20% patients with AML carry DNMT3A gene mutations and was associated with a poor clinical outcome. but its clinical implications in Chinese AML patients are largely unknown .We analyzed 101 adult AML patients in china and found 14 patients (13.9%) harboring this mutation. 9 patient with M5, 2 patients with M1, 2patient with M2 and 1 patient with M3. We identified 11 missense mutation,2 nonsense and 30 bp deletion encompassing DNMT3A. The most common of them was predicted to affect 882Arg(in 4 patient...
Source: BioMed Central - January 11, 2013 Category: Journals (General) Authors: Quanyi LuYamei ChenHang WangZhipeng Li Source Type: research

Major depression epidemiology from a diathesis-stress conceptualization
Conclusions: A diathesis-stress conceptualization coupled with application of a threshold-based diagnostic definition may explain several of the apparent complexities of major depression epidemiology. Some of these complexities may be artifacts of the nominal diagnostic approach. These observations should encourage an empirical exploration of whether diathesis-stress interactions provide a more parsimonious framework for understanding depression than current approaches.
Source: BioMed Central - January 11, 2013 Category: Journals (General) Authors: Scott B Patten Source Type: research

Imputing forest carbon stock estimates from inventory plots to a nationally continuous coverage
The U.S. has been providing national-scale estimates of forest carbon (C) stocks and stock change to meet United Nations Framework Convention on Climate Change (UNFCCC) reporting requirements for years. Although these currently are provided as national estimates by pool and year to meet greenhouse gas monitoring requirements, there is growing need to disaggregate these estimates to finer scales to enable strategic forest management and monitoring activities focused on various ecosystem services such as C storage enhancement. Through application of a nearest-neighbor imputation approach, spatially extant estimates of forest...
Source: BioMed Central - January 11, 2013 Category: Journals (General) Authors: Barry Tyler WilsonChristopher W WoodallDouglas M Griffith Source Type: research

Immunostimulatory activity of Stachys mialhesi de Noe
Conclusion: S.mialhesi extract exhibited a dose-dependent immunostimulant effect on the reticuloendothelial system, which could be attributed to the presence of active principles in this butanolic extract.
Source: BioMed Central - January 11, 2013 Category: Journals (General) Authors: Assia BenmebarekSakina ZerizerSouheila LaggouneZahia Kabouche Source Type: research

Rebuilding community resilience in a post-war context: developing insight and recommendations - a qualitative study in Northern Sri Lanka
Conclusions: In view of the widespread trauma at the individual, family and collective levels, community based programmes to increase local awareness, knowledge and skills to deal with common mental health and psychosocial issues; training of community level workers and others in basic mental health and psychosocial problem solving are recommended to rebuild family and community agency and resilience. The use of cultural practices and school based programmes would rekindle community processes.
Source: BioMed Central - January 11, 2013 Category: Journals (General) Authors: Daya SomasundaramSambasivamoorthy Sivayokan Source Type: research

An expected association between low haemoglobin and poor outcome in severe head injury and an insufficiently detailed multivariate analysis
I read with interest the paper by Sekhon et al, 'Association of hemoglobin concentration in critically ill patients with severe traumatic brain injury' (July edition of Critical Care) [1]. Whilst the conclusion ('mean 7-day hemoglobin concentration < 90g/L associated with increased hospital mortality in patients with severe traumatic brain injury') is striking, it is plausible, if not likely, that both the haemoglobin deficit and the observed mortality are dependent upon the severity of the initial injury, and therefore an association between these two might be expected.Given the lack of transfusion trigger and a target ha...
Source: BioMed Central - January 11, 2013 Category: Journals (General) Authors: Kieran Donnelly Source Type: research

Reflections on fertility and postponed parenthood-interviews with highly educated women and men without children in Sweden.
Conclusion. Highly educated young women and men in contemporary Sweden have competing priorities when planning and setting goals for their lives, and having children is one of them. They describe fertility as an imperceptible and retrievable capacity and postponed parenthood as a rational adaptation to changes in society. These findings suggest that increased information about the limitations of human reproduction is needed, but also that societal support for younger parents is of utmost importance. PMID: 23305524 [PubMed - as supplied by publisher]
Source: Upsala Journal of Medical Sciences - January 10, 2013 Category: Journals (General) Authors: Eriksson C, Larsson M, Skoog Svanberg A, Tydén T Tags: Ups J Med Sci Source Type: research

Feasibility study of an optimised person-centred intervention to improve mental health and reduce antipsychotics amongst people with dementia in care homes: study protocol for a randomised controlled trial
DiscussionThe overarching goal of the programme is to provide an effective, simple and practical intervention which improves the mental health of, and reduces sedative drug use in, people with dementia in care homes and which can be implemented nationally in all UK care homes as an NHS intervention.Trial Registration: Current controlled trials ISRCTN40313497
Source: Trials - January 10, 2013 Category: Journals (General) Authors: Rhiannon WhitakerClive BallardJane StaffordMartin OrrellEsme Moniz-CookRobert WoodsJoanna MurrayMartin KnappBarbara CarltonJane Fossey Source Type: research

Health Professionals' Expectations Versus Experiences of Internet-Based Telemonitoring: Survey Among Heart Failure Clinics
Conclusions: One third of all heart failure clinics surveyed were using telemonitoring as part of their care without any transparent, predefined criteria of user requirements. Prior expectations of telemonitoring were not reflected in actual experiences, possibly leading to disappointment.
Source: Journal of Medical Internet Research - January 10, 2013 Category: Journals (General) Authors: Arjen E. de VriesMartje H.L. van der WalMaurice M.W. NieuwenhuisRichard M. de JongRene B. van DijkTiny JaarsmaHans L. Hillege Source Type: research

Aboriginal-mainstream partnerships: exploring the challenges and enhancers of a collaborative service arrangement for Aboriginal clients with substance use issues
Conclusion: While the literature strongly advises partnerships be suitably mature before commencing service delivery, the reality of funding cycles may require partnerships become operational before relationships are adequately consolidated. Allowing sufficient time and funding for both the operation and relational aspects of a partnership is critical, with support for partners to regularly meet and workshop arrangements. Documentation that makes clear and embeds working arrangements between partners is important to ameliorate many of the issues that can arise. Given the historical undercurrents, flexible approaches are re...
Source: BMC Health Services Research - January 10, 2013 Category: Journals (General) Authors: Kate TaylorDawn BessarabLorna HunterSandra Thompson Source Type: research

Risk adjustment for cesarean delivery rates: how many variables do we need? An observational study using administrative databases
Conclusions: Record linkage improves the performance of the models but does not affect inter-hospital comparisons.
Source: BMC Health Services Research - January 10, 2013 Category: Journals (General) Authors: Elisa StivanelloPaola RucciElisa CarrettaGiulia PieriMaria Fantini Source Type: research

Reducing unnecessary hospital days to improve quality of care through physician accountability: a cluster randomised trial
Conclusions: Results indicate that a strategy, involving physician direct accountability, can reduce unnecessary hospital days. Relatively simple interventions, like the one assessed in this study, should be implemented in all hospitals with excessive lengths of stay, since unnecessary prolongation may be harmful to patients.Trial registration: ClinicalTrials.gov, identifier NCT01422811.
Source: BMC Health Services Research - January 10, 2013 Category: Journals (General) Authors: Caterina CaminitiTiziana MeschiLuca BragliaFrancesca DiodatiElisa IezziBarbara MarcominiAntonio NouvenneEliana PalermoBeatrice PratiTania SchianchiLoris Borghi Source Type: research

Development of mental health quality indicators (MHQIs) for inpatient psychiatry based on the interRAI mental health assessment
Conclusions: The RAI-MH is a feasible assessment system for deriving MHQIs. Given the breadth of clinical content on the RAI-MH there is an opportunity to expand the number of MHQIs beyond indicators of depression, cognitive performance, and restraints. Further research is needed to improve risk adjustment of the MHQIs for their use in mental health services report card and benchmarking activities.
Source: BMC Health Services Research - January 10, 2013 Category: Journals (General) Authors: Christopher PerlmanJohn HirdesHoward BarbareeBrant FriesIan McKillopJohn MorrisTerry Rabinowitz Source Type: research

Is 50 cent the price of the optimal copayment? - a qualitative study of patient opinions and attitudes in response to a 50 cent charge on prescription drugs in a publicly funded health system in Ireland
Conclusions: This qualitative study gives important insights into the experiences of GMS patients with regard to the prescription levy. Information regarding the appropriateness of a 50 cent copayment as a symbolic copayment needs to be confirmed by quantitative analysis. Further insight is required from a younger population.
Source: BMC Health Services Research - January 10, 2013 Category: Journals (General) Authors: Sarah-Jo SinnottMarie GuinaneHelen WheltonStephen Byrne Source Type: research

Sensitivity and specificity of Norwegian optometrists' evaluation of diabetic retinopathy in single-field retinal images -- a cross-sectional experimental study
Conclusions: The evaluation of retinal images for diabetic retinopathy by Norwegian optometrists does not meet the required screening standard of at least 80 % sensitivity and 95 % specificity. The introduction of measures to improve this situation could have implications for both formal optometric training and continuing optometric professional education.
Source: BMC Health Services Research - January 10, 2013 Category: Journals (General) Authors: Vibeke SundlingPål GulbrandsenJørund Straand Source Type: research

A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus
An automated luminescent-based high throughput screen was developed to test inhibitors of RSV, leading to the discovery of aryl sulfonylpyrrolidines as potential therapeutics for this important childhood disease.
Source: BioMed Central - January 10, 2013 Category: Journals (General) Authors: Dong-Hoon ChungBlake P MooreDaljit S MatharuJennifer E GoldenClinton MaddoxLynn RasmussenMelinda I SosaSubramaniam AnanthanE Lucile WhiteFuli JiaColleen B JonssonWilliam E Severson Source Type: research

Clinical effect of catgut implantation at acupoints for allergic rhinitis: study protocol for a randomized controlled trial
This study aims to identify whether catgut implantation at acupoints is indeed an effective and safe treatment for patients with persistent or intermittent allergic rhinitis (PER or IAR) by comparing with sham catgut implantation treatment.Methods and design: This study compares real versus sham catgut implantation at acupoints in 242 patients with a history of PER or IAR and with a positive skin prick test (SPT). The trial will be conducted in the Teaching Hospital of Chengdu University of Traditional Chinese Medicine. In the study, patients will be randomly assigned by computer-generated randomization list into two group...
Source: BioMed Central - January 10, 2013 Category: Journals (General) Authors: Xinrong LiQinxiu ZhangLuyun JiangTao LiMin LiuHuanxing LiuXiaopei WangFubing Zhang Source Type: research

Oral care and pulmonary infection - the importance of plaque scoring
Improving the quality of oral hygiene is recognised as an important counter measure for reducing the incidence of ventilator associated pneumonia amongst critically ill patients. Toothbrushing physically disrupts the dental plaque that acts as a reservoir for pulmonary infection and therefore has the potential to reduce the incidence of ventilator associated pneumonia. Gu and colleagues performed a systematic review and meta-analysis of oral hygiene with and without a toothbrush and found no difference on the incidence of pneumonia in mechanically ventilated patients. The diagnosis of ventilator associated pneumonia is pro...
Source: BioMed Central - January 10, 2013 Category: Journals (General) Authors: Matt P WiseDavid W Williams Source Type: research

Calcific Uremic Arteriopathy.
PMID: 23313948 [PubMed - as supplied by publisher]
Source: The American Journal of the Medical Sciences - January 9, 2013 Category: Journals (General) Authors: Wu MH, Yang SF, Lin YP Tags: Am J Med Sci Source Type: research

Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis-A Dastardly Duo.
Abstract ABSTRACT:: Pulmonary hypertension (PH) is a well-recognized complication of interstitial lung disease, including idiopathic pulmonary fibrosis (IPF). The underlying pathogenesis was initially hypothesized to be inflammatory but now is characterized as an over exuberant fibroproliferative process. The prevalence of PH in the setting of IPF has not been well described in the literature, with a reported occurrence from 32% to 85%. Diagnostically, recognizing underlying PH in the setting of IPF remains challenging because of nonspecific clinical symptoms and unrevealing ancillary testing. A high degree of clin...
Source: The American Journal of the Medical Sciences - January 9, 2013 Category: Journals (General) Authors: Smith JS, Gorbett D, Mueller J, Perez R, Daniels CJ Tags: Am J Med Sci Source Type: research

Suppression of Primary Aldosteronism and Resistant Hypertension by the Peroxisome Proliferator-activated Receptor Gamma Agonist Pioglitazone.
We report a case of 55-year-old man with primary aldosteronism (PA) whose hyperaldosteronism was suppressed with the PPAR γ agonist pioglitazone. He had drug-resistant hypertension, hypokalemia, and diabetes mellitus. The diagnosis of PA was confirmed by the oral sodium loading test (20.5 μg/d of urinary aldosterone) and Captopril challenge test (19.5 ng/dL of plasma aldosterone). Computed tomography imaging revealed no apparent adrenal mass. The result of the posture stimulation test was consistent with the diagnosis of idiopathic adrenal hyperplasia. On administration of pioglitazone (30 mg/d) and nifedipine (40 mg/d),...
Source: The American Journal of the Medical Sciences - January 9, 2013 Category: Journals (General) Authors: Kashiwagi Y, Mizuno Y, Harada E, Shono M, Morita S, Yoshimura M, Yano M, Yasue H Tags: Am J Med Sci Source Type: research

Context Specific Protein Tyrosine Kinase 6 (PTK6) Signaling in Prostate Cancer
ConclusionsIn human prostate cancer, elevated PTK6 expression, translocation of PTK6 from the nucleus to the cytoplasm, and its activation at the plasma membrane, contribute to increased phosphorylation and activation of its substrates such as AKT, p130CAS and FAK, thereby promoting prostate cancer progression.
Source: European Journal of Clinical Investigation - January 9, 2013 Category: Journals (General) Authors: Yu Zheng, Angela L. Tyner Tags: Review Source Type: research

Relationship of pentraxin 3 with insulin sensitivity in gestational diabetes
ConclusionsDependence of PTX3 on serum glucose levels was more pronounced in women with GDM than in the NGT group. This notion together with its inverse relation to the parameters of insulin sensitivity, suggests a potential involvement of PTX3 in GDM pathology.
Source: European Journal of Clinical Investigation - January 9, 2013 Category: Journals (General) Authors: Jelena Todoric, Ammon Handisurya, Bernhard Knapp, Andrea Tura, Giovanni Pacini, Alexandra Kautzky‐Willer Tags: Original Article Source Type: research

The MAINTAIN study-managing hemoglobin variability with darbepoetin alfa in dialysis patients experiencing a severe drop in hemoglobin.
CONCLUSIONS: This observational study describes physicians' reactions to a drop in hemoglobin in clinical practice. Using darbepoetin alfa, the drop was generally compensated without leading to overcorrection. PMID: 23299452 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - January 9, 2013 Category: Journals (General) Authors: Watschinger B, Salmhofer H, Horn S, Neyer U, Wiesinger T, Wiesholzer M, Erb H, Jaeger C, Hemetsberger M, Rosenkranz AR Tags: Wien Klin Wochenschr Source Type: research

Cellular versus acellular matrix devices in treatment of diabetic foot ulcers: study protocol for a comparative efficacy randomized controlled trial
DiscussionIf our hypothesis is correct, then immense cost savings could be realized by using the orders-of-magnitude less expensive acellular ECM device without compromising patient health outcomes. The article describes the protocol proposed to test our hypothesis.Trial registration: ClinicalTrials.gov: NCT01450943. Registered: 7 October 2011
Source: Trials - January 9, 2013 Category: Journals (General) Authors: Hadar Lev-TovChin-Shang LiSara DahleRoslyn Isseroff Source Type: research

Improving the application of a practice guideline for the assessment and treatment of suicidal behavior by training the full staff of psychiatric departments via an e-learning supported Train-the-Trainer program: study protocol for a randomized controlled trial
This article describes the design of a study measuring the effect of an e-learning supported Train-the-Trainer program aiming at the training of the full staff of departments in the application of the guideline. We hypothesize that both professionals and departments will benefit from the program.MethodIn a multicenter cluster randomized controlled trial, 43 psychiatric departments spread over 10 regional mental health institutions throughout The Netherlands will be clustered in pairs with respect to the most prevalent diagnostic category of patients and average duration of treatment. Pair members are randomly allocated to ...
Source: Trials - January 9, 2013 Category: Journals (General) Authors: Derek de BeursMarieke de GrootJos de KeijserBastiaan VerweyJan MokkenstormJos TwiskErik van DuijnAlbert van HemertLia VerlindeJan SpijkerBert van LuijnJan VinkAd Kerkhof Source Type: research

Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): study protocol for a randomised controlled trial
This report describes a randomised controlled trial that will provide evidence of any benefit of treating diarrhoea-predominant IBS patients with mesalazine. The results will be available toward the end of 2013.Trial registration: ISRCTN76612274
Source: Trials - January 9, 2013 Category: Journals (General) Authors: Matthew LeightonChing LamSamir MehtaRobin Spiller Source Type: research

The Nordic Aortic Valve Intervention (NOTION) trial comparing transcatheter versus surgical valve implantation: study protocol for a randomised controlled trial
DiscussionThe trial is designed to evaluate the performance of TAVI in comparison with SAVR. The trial results may influence the choice of treatment modality for patients with severe degenerative AV stenosis.Trial registration: ClinicalTrials.gov: NCT01057173
Source: Trials - January 9, 2013 Category: Journals (General) Authors: Hans ThyregodLars SøndergaardNikolaj IhlemannOlaf FranzenLars AndersenPeter HansenPeter OlsenHenrik NissenPer WinkelChristian GluudDaniel Steinbrüchel Source Type: research

Effectiveness of a Web-Based Cognitive-Behavioral Tool to Improve Mental Well-Being in the General Population: Randomized Controlled Trial
Conclusions: Participants allocated to the intervention arm had an average increase of approximately 3 points on the WEMWBS scale compared to no increase for participants in the control group. Three points on this scale is approximately one-third of a standard deviation. In a low-cost automated intervention designed to shift the population distribution of mental well-being, a small difference per individual could yield a major benefit in population terms. In common with other Web-based interventions, there were high rates of attrition. Further work is needed to improve acceptability, to evaluate against placebo effect, and...
Source: Journal of Medical Internet Research - January 9, 2013 Category: Journals (General) Authors: John PowellThomas HamborgNigel StallardAmanda BurlsJaime McSorleyKylie BennettKathleen M GriffithsHelen Christensen Source Type: research

Self-disembowelment
A case of self-disembowelment is presented with an overview of self-disembowelment as cultural entity.
Source: BioMed Central - January 8, 2013 Category: Journals (General) Authors: Walter M van den BerghDavid J van WesterlooVincent M de Jong Source Type: research

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome
Lam and colleagues review the different subtypes of Alzheimer's disease (AD), discussing the need for personalized AD medicine and the potential for targeting specific AD subtypes in future clinical trials.
Source: BioMed Central - January 8, 2013 Category: Journals (General) Authors: Benjamin LamMario MasellisMorris FreedmanDonald T StussSandra E Black Source Type: research

Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke
This article summarizes the current literatures on NBO as a simple, widely accessible, and potentially cost-effective therapeutic strategy for treatment of acute ischemic stroke.
Source: BioMed Central - January 8, 2013 Category: Journals (General) Authors: Zhifeng QiWenlan LiuYumin LuoXunming JiKe Jian Liu Source Type: research

Changes in Timing and kinematics of goal directed eye-hand movements in early-stage Parkinson's disease
ObjectiveMany daily activities involve intrinsic or extrinsic goal-directed eye and hand movements. An extensive visuomotor coordination network including nigro-striatal pathways is required for efficient timing and positioning of eyes and hands. The aim of this study was to investigate how Parkinson's disease (PD) affects eye-hand coordination in tasks with different cognitive complexity. Methods: We used a touch screen, an eye-tracking device and a motion capturing system to quantify changes in eye-hand coordination in early-stage PD patients (H&Y < 2.5) and age-matched controls. Timing and kinematics of eye and hand wer...
Source: BioMed Central - January 8, 2013 Category: Journals (General) Authors: Danya MuilwijkSimone VerheijJohan JM PelAgnita JW BoonJohannes van der Steen Source Type: research

Reducing and meta-analysing estimates from distributed lag non-linear models
ConclusionsThe methodology proposed here extends the use of DLNMs in two-stage analyses, obtainingmeta-analytical estimates of easily interpretable summaries from complex non-linear and delayedassociations. The approach relaxes the assumptions and avoids simplifications required by simplermodelling approaches.
Source: BioMed Central - January 8, 2013 Category: Journals (General) Authors: Antonio GasparriniBen Armstrong Source Type: research

Dosimetric parameter predicting the deterioration of hepatic function after helical tomotherapy in patients with unresectable locally advanced hepatocellular carcinoma
Conclusions: An increase of at least 2 points in the CP score is a radiation dose-limiting factor, and the non-target normal liver receiving a dose more than 15 Gy (V15Gy) should be
Source: BioMed Central - January 8, 2013 Category: Journals (General) Authors: Seok Hyun SonChul Seung KayJin Ho SongSea-Won LeeByung Ock ChoiYoung Nam KangJeong Won JangSeung Kew YoonHong Seok Jang Source Type: research

[Which vaccination and cardiovascular prevention in elderly?]
Abstract Vaccination especially influenza, tetanus and pneumococcus should be used by the physician as an effective preventive measure. Stop smoking prevents the occurrence of cardiovascular event as the control of blood pressure in elderly healthy. It is very important to treat atrial fibrillation in elderly. In elderly aged over 80 years, primary prevention of dyslipidemia by statins is controversial whereas secondary prevention of cardiovascular events by statins is effective. PMID: 23312926 [PubMed - as supplied by publisher]
Source: Presse Medicale - January 8, 2013 Category: Journals (General) Authors: Krypciak S, Mézière A, Belmin J, Herbaud S, Paillaud E Tags: Presse Med Source Type: research

[Anticoagulation of older patients: What is new?]
Abstract Vitamin-K antagonists (VKA) are the current standard for oral anticoagulation. However, they carry several problems in older patients: frequent bleeding complications, complex management, risk of interactions with multiple drugs. Two new classes of oral anticoagulants (NOA) are now available: direct thrombin inhibitors (dabigatran); and direct factor Xa inhibitors (rivaroxaban, apixaban) and others. Their management is easier: quickly effective after administration, they are given at fixed doses and do not need regular laboratory monitoring. Several randomized trials have shown that NOA are non-inferior to...
Source: Presse Medicale - January 8, 2013 Category: Journals (General) Authors: Lafuente-Lafuente C, Pautas E, Belmin J Tags: Presse Med Source Type: research

We will all be satisfied in the end.
PMID: 23306975 [PubMed - as supplied by publisher]
Source: Tidsskrift for den Norske Laegeforening - January 8, 2013 Category: Journals (General) Authors: Hem E Tags: Tidsskr Nor Laegeforen Source Type: research

[In Process Citation].
PMID: 23306976 [PubMed - in process]
Source: Tidsskrift for den Norske Laegeforening - January 8, 2013 Category: Journals (General) Authors: Bjørner T Tags: Tidsskr Nor Laegeforen Source Type: research

Exercise yourself thin - a myth?
PMID: 23306977 [PubMed - as supplied by publisher]
Source: Tidsskrift for den Norske Laegeforening - January 8, 2013 Category: Journals (General) Authors: Hjelmesæth J Tags: Tidsskr Nor Laegeforen Source Type: research

[In Process Citation].
PMID: 23306978 [PubMed - in process]
Source: Tidsskrift for den Norske Laegeforening - January 8, 2013 Category: Journals (General) Authors: Wyller VB Tags: Tidsskr Nor Laegeforen Source Type: research