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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 31.

[The heart as an endocrine organ].
Abstract The discovery of cardiac hormone production significantly changed the evaluation of the function of the heart, which is rather regarded as a determining factor of the electrolyte and hemodynamic homeostasis cooperating with other organ systems instead of a mechanical pump. The most important hormones produced by the heart are the natriuretic peptides that have the primary role of protection against volume overload through natriuretic, diuretic, vasodilator and antiproliferative effects. They are integrative markers of the cardiac, vascular and renal functions and marking cardiorenal distress. Brain natriur...
Source: Orvosi Hetilap - December 22, 2012 Category: Journals (General) Authors: Mezősi E, Bajnok L, Tóth K Tags: Orv Hetil Source Type: research

Arrhythmias in primary hyperparathyroidism evaluated by exercise test
ConclusionsIn patients with PHPT, an increased occurrence of VPBs and a different QTc adaptation during ET were observed and may represent risk factors for major arrhythmias.
Source: European Journal of Clinical Investigation - December 22, 2012 Category: Journals (General) Authors: Jessica Pepe, Mario Curione, Sergio Morelli, Marco Colotto, Marisa Varrenti, Claudia Castro, Antonella D'Angelo, Cristiana Cipriani, Sara Piemonte, Elisabetta Romagnoli, Salvatore Minisola Tags: Original Article Source Type: research

Abdominal obesity and prolonged prone positioning increase risk of developing sclerosing cholangitis in critically ill patients with influenza A-associated ARDS
Conclusion: Our results suggest that obesity, intraperitoneal fat volume, and a longer cumulative duration spent in the prone position may put patients with ARDS at risk of developing SC-CIP. These results lead us to propose that the prone position should be carefully deployed, particularly in abdominally obese patients, and that frequent checks be made for early hepatic dysfunction.
Source: BioMed Central - December 22, 2012 Category: Journals (General) Authors: Thomas WeigMirjam I SchubertNorbert GruenerMichael E DolchLorenz FreyJens MillerThorsten JohnsonMichael Irlbeck Source Type: research

Speech recognition index of workers with tinnitus exposed to environmental or occupational noise: a comparative study
Conclusion: Studied group's high prevalence of tinnitus, major difficulties in speech recognition with hearing loss and the presence of individuals with normal hearing with both types of exposure justify the importance of measures in health promotion, prevention, and hearing surveillance. The findings highlight the importance of valuing the patients' own perception as the first indication of tinnitus and hearing loss in order to help develop appropriate public policies within the Unified National Health System (SUS).
Source: BioMed Central - December 22, 2012 Category: Journals (General) Authors: Márcia SoalheiroLucelaine RochaDiane Francis do ValeViviane FontesDaniel ValenteLiliane Reis Teixeira Source Type: research

Determining adult type 2 diabetes-related health care needs in an indigenous population from rural Guatemala: a mixed-methods preliminary study
Conclusions: This study provides a preliminary sketch of type 2 diabetes in an indigenous Guatemalan population. Combined qualitative and quantitative data point towards particular needs for implementation and future research, including the need to address gaps in diabetes knowledge, to improve social support systems, and to address the cost barriers associated with disease treatment.
Source: BMC Health Services Research - December 22, 2012 Category: Journals (General) Authors: Anita CharyMiranda GreinerCody BowersPeter Rohloff Source Type: research

Shaping healthcare-seeking processes during fatal illness in resource-poor settings. A study in Lao PDR
Conclusions: Care-seeking is influenced by family- and community-based relations, which are integrated parts of people's everyday life. The medical and normative responses from health providers affect the behavior of care-seekers. An anthropological approach to capture the experience of caregivers in relation to deciding, seeking and reaching care reveals the complexity and socio-cultural context surrounding maternal and child mortality and has implications for how future mortality data should be developed and interpreted.
Source: BMC Health Services Research - December 22, 2012 Category: Journals (General) Authors: Helle AlvessonMagnus LindelowBouasavanh KhanthaphatLucie Laflamme Source Type: research

Journal round up.
Authors: PMID: 23263786 [PubMed - as supplied by publisher]
Source: J R Soc Med AND (has... - December 21, 2012 Category: Journals (General) Tags: J R Soc Med Source Type: research

Recurring Extracorporeal Circuit Clotting During Continuous Renal Replacement Therapy in a Patient With Scedosporium prolificans-Induced Fungal Sepsis: Successful Treatment With Argatroban.
In this study, the case of a 46-year-old man who developed fungal mediastinitis with the pathogen Scedosporium prolificans after coronary bypass surgery is reported. Numerous debridements and multiple antifungal agents were not effective in this patient. Miltefosine, a non-Food and Drug Administration-approved agent, was started after institutional review board request and approval. CRRT was initiated with regional citrate anticoagulation (RCA) for clinical sepsis with acute kidney injury. Subsequently, crescendo clotting of the extracorporeal circuit (ECC) occurred. Multiple interventions, including escalating RCA, adding...
Source: The American Journal of the Medical Sciences - December 21, 2012 Category: Journals (General) Authors: Ferguson LM, Dreisbach AW, Csongrádi E, Juncos LA, Fulop T Tags: Am J Med Sci Source Type: research

Lymphoma Presenting as a Giant Chest Wall Mass.
PMID: 23267233 [PubMed - as supplied by publisher]
Source: The American Journal of the Medical Sciences - December 21, 2012 Category: Journals (General) Authors: Zheng Z, Xiao Z, Fang Z, Pan Y Tags: Am J Med Sci Source Type: research

Detection of Risky Esophageal Varices by Two-Dimensional Ultrasound: When to Perform Endoscopy.
CONCLUSIONS:: The intra-abdominal esophagus should be observed during abdominal ultrasound examination in patients with liver cirrhosis. Two-dimensional ultrasound can play an important role in screening for esophageal varices. PMID: 23267234 [PubMed - as supplied by publisher]
Source: The American Journal of the Medical Sciences - December 21, 2012 Category: Journals (General) Authors: Abd Elrazek AE, Mahfouz H, Afifi M, Nafady M, Fathy AE, Elazeem KA, Amer K, El-Shamy A, Kenji U, Ghaibeh AA, Bilasy S, El-Ansary N, Fakhry M, Mansour M Tags: Am J Med Sci Source Type: research

Astragalus Extract Attenuates Allergic Airway Inflammation and Inhibits Nuclear Factor κB Expression in Asthmatic Mice.
CONCLUSIONS:: Taken together, our current study demonstrated a potential therapeutic value of astragalus extract in the treatment of asthma and it may act by inhibiting the expression of the NF-κB pathway. PMID: 23267235 [PubMed - as supplied by publisher]
Source: The American Journal of the Medical Sciences - December 21, 2012 Category: Journals (General) Authors: Yang ZC, Qu ZH, Yi MJ, Wang C, Ran N, Xie N, Fu P, Feng XY, Lv ZD, Xu L Tags: Am J Med Sci Source Type: research

Uric acid for diagnosis and risk stratification in suspected myocardial infarction
ConclusionsUric acid, an inexpensive widely available biomarker, improves both the early diagnosis and risk stratification of patients with suspected AMI.
Source: European Journal of Clinical Investigation - December 21, 2012 Category: Journals (General) Authors: Karin Wildi, Philip Haaf, Tobias Reichlin, Resat Acemoglu, Jeannine Schneider, Cathrin Balmelli, Beatrice Drexler, Raphael Twerenbold, Tamina Mosimann, Miriam Reiter, Mira Mueller, Susanne Ernst, Paola Ballarino, Christa Zellweger, Berit Moehring, Carles Tags: Original Article Source Type: research

[Antihyperglycemic Treatment Guidelines for diabetes mellius type 2.]
Abstract Hyperglycemia significantly contributes to micro- and macrovascular complications in patients with diabetes mellitus. While lifestyle interventions remain cornerstones of disease prevention and treatment, most patients with type 2 diabetes will eventually require pharmacotherapy for glycemic control. The definition of individual targets in regard of optimal therapeutic efficacy and high therapeutic safety is of great importance. In this guideline we present the best and most current evidence-based clinical practice data for healthcare professionals. PMID: 23262748 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - December 21, 2012 Category: Journals (General) Authors: Clodi M, Abrahamian HE, Drexel HE, Fasching P, Hoppichler F, Kautzky-Willer A, Lechleitner M, Ludvik B, Prager R, Roden M, Saely C, Schernthaner G, Schober E, Toplak H, Wascher T, Weitgasser R Tags: Wien Klin Wochenschr Source Type: research

ADAMTS13 Deficiency and Thrombotic Thrombocytopenic Purpura Associated with Trimethoprim-Sulfamethoxazole.
We present the case of a 26-year-old healthy woman who developed TTP during TMP-SMX therapy for urinary tract infection. She was found to have ADAMTS13 deficiency with anti-ADAMTS13 antibodies. Her condition responded to discontinuation of the TMP-SMX, plasmapheresis, and rituximab therapy. We speculate that the acquired ADAMTS13 deficiency might have been triggered by the TMP-SMX therapy. PMID: 23262188 [PubMed - as supplied by publisher]
Source: Clinical Medicine and Research - December 21, 2012 Category: Journals (General) Authors: Bapani S, Epperla N, Kasirye Y, Mercier R, Garcia-Montilla R Tags: Clin Med Res Source Type: research

Laboratory Evaluation for Vitamin B12 Deficiency: The Case for Cascade Testing.
ConclusionsCurrently, only a small minority of patients initiated on intramuscular vitamin B(12) supplementation derive any meaningful clinical benefit. Furthermore, current testing recommendations for vitamin B(12) deficiency are usually not followed. Up-front ordering of a diagnostic testing cascade is recommended to improve compliance; an example is presented with decision points chosen to improve specificity for clinically evident vitamin B(12) deficiency without loss of sensitivity. Ultimately, a better understanding of vitamin B(12) physiology is needed to develop and evaluate laboratory tests that more accurately re...
Source: Clinical Medicine and Research - December 21, 2012 Category: Journals (General) Authors: Berg RL, Shaw GR Tags: Clin Med Res Source Type: research

Gastric Antral Vascular Ectasia: Case Report and Review of the Literature.
We report two cases of gastric antral vascular ectasia with two strikingly different endoscopic appearances. We further describe the clinical, endoscopic, histologic, and therapeutic aspects of this entity. PMID: 23262190 [PubMed - as supplied by publisher]
Source: Clinical Medicine and Research - December 21, 2012 Category: Journals (General) Authors: Kar P, Mitra S, Resnick JM, Torbey CF Tags: Clin Med Res Source Type: research

Factors Affecting Mobile Diabetes Monitoring Adoption Among Physicians: Questionnaire Study and Path Model
Conclusions: Physicians consider perceived value and net benefits as the most important motivators to use mobile diabetes monitoring. Overall quality assessment does affect their intention to use this technology, but only indirectly through perceived value. Net benefits seem to be a strong driver in both a direct and indirect manner, implying that physicians may perceive health improvement with ubiquitous control as a true utility by enhancing cost-effective monitoring, and simultaneously recognize it as a way to create value for their clinical practices.
Source: Journal of Medical Internet Research - December 21, 2012 Category: Journals (General) Authors: Shintaro OkazakiJosé Alberto CastañedaSilvia SanzJörg Henseler Source Type: research

RNAmap2D -- calculation, visualization and analysis of contact and distance maps for RNA and protein-RNA complex structures
Conclusions: RNAmap2D is an easy to use method to visualize, analyze and compare structures of nucleic acid molecules and their complexes with other molecules, such as proteins or ligands and metal ions. Its special features make it a very useful tool for analysis of tertiary structures of RNAs. RNAmap2D for Windows/Linux/MacOSX is freely available for academic users at http://iimcb.genesilico.pl/rnamap2d.html
Source: BioMed Central - December 21, 2012 Category: Journals (General) Authors: Michal J PietalNatalia SzostakKristian M RotherJanusz M Bujnicki Source Type: research

Sporadic incidence of Fascioliasis detected during Hepatobiliary procedures: A study of 18 patients from Sulaimaniyah governorate
Conclusion: Fascioliasis is indeed an emerging disease in our locality, but it is often underestimated and ignored. We recommend the differential diagnosis of patients suffering from Rt. Hypochondrial pain, fever and eosinophilia. The watercress ingestion was a common factor in patient's history.
Source: BioMed Central - December 21, 2012 Category: Journals (General) Authors: Tahir Abdullah HawramyKamal Ahmed SaeedSeerwan Hama QaradaghyTaha Ahmed KarboliBeston Faiek NoreNoora Hisham Bayati Source Type: research

Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway
Conclusions: These results show that SAH induces early activation of the MEK-ERK1/2 pathway in cerebral artery walls, which is associated with upregulation of proinflammatory cytokines and MMP-9. Inhibition of the MEK-ERK1/2 pathway by U0126 starting at 6 h post-SAH prevented upregulation of cytokines and MMP-9 in cerebral vessels, and improved neurological outcome.
Source: BioMed Central - December 21, 2012 Category: Journals (General) Authors: Aida MaddahiGro PovlsenLars Edvinsson Source Type: research

Multidetector-row computed tomography for evaluating the branching angle of the celiac artery: a descriptive study
Conclusions: The branching angle of the celiac artery can be easily determined by the preparation of MIP images from routine MDCT data. MIP may provide useful information for the selection of the catheter insertion route in order to avoid a sharp branching angle of the celiac artery.
Source: BioMed Central - December 21, 2012 Category: Journals (General) Authors: Hiroyuki TokueAzusa TokueYoshito Tsushima Source Type: research

Clinical use of exhaled volatile organic compounds in pulmonary diseases: a systematic review
In conclusion, profiles of VOCs are potentially able to accurately diagnose various pulmonary diseases. Despite these promising findings, multiple challenges such as further standardization and validation of the diverse techniques need to be mastered before VOCs can be applied into clinical practice.
Source: BioMed Central - December 21, 2012 Category: Journals (General) Authors: Kim DG van de KantLinda JTM van der SandeQuirijn JöbsisOnno CP van SchayckEdward Dompeling Source Type: research

Detection of hantavirus in bats from remaining rain forest in Sao Paulo, Brazil
Conclusions: The analysis of nucleotide sequences of the partial S segment revealed that these genes were more related to the Araraquara virus strains. This work reinforces the importance of studying hantavirus in different animal species and performing a continued surveillance before this virus spreads in new hosts and generated serious problems in public health.
Source: BioMed Central - December 21, 2012 Category: Journals (General) Authors: Jansen de AraujoLuciano Matsumiya ThomazelliDyana Alves HenriquesDaniele LautenschalagerTatiana OmettoLilia Mara DutraCaroline Cotrin AiresSandra FavoritoEdison Luiz Durigon Source Type: research

Genomic organization, evolution, and expression of photoprotein and opsin genes in Mnemiopsis leidyi: a new view of ctenophore photocytes
The comb jelly Mnemiopsis leidyi has at least ten distinct genes encoding enzymes that catalyse bioluminescence. Their evolutionary origin traces back to the earliest animals, and in Mnemiopsis they are co-expressed with light-absorbing opsin in light-detecting cells. 
Source: BioMed Central - December 21, 2012 Category: Journals (General) Authors: Christine E SchnitzlerKevin PangMeghan L PowersAdam M ReitzelJoseph F RyanDavid SimmonsTakashi TadaMorgan ParkJyoti GuptaShelise Y BrooksRobert W BlakesleyShozo YokoyamaSteven HD HaddockMark Q MartindaleAndreas D Baxevanis Source Type: research

Designation, diligence and drift: understanding laboratory expenditure increases in British Columbia, 1996/97 to 2005/06
Conclusion: Increases in treatment prevalence were the largest driver of laboratory cost increases between 1996/97 and 2005/06. There are several possible contributors to increasing treatment prevalence, all of which can be expected to continue to put pressure on health care expenditures.
Source: BMC Health Services Research - December 21, 2012 Category: Journals (General) Authors: Saskia SivananthanSandra PetersonRuth LavergneMorris BarerKimberlyn McGrail Source Type: research

Profiling the different needs and expectations of patients for population-based medicine: a case study using segmentation analysis
Conclusions: With this research, we provide the following:a method for profiling patients based on common patient satisfaction surveys that is easily replicable in all health systems and contexts;a proposal for segments based on the results of a broad-based analysis conducted in the Italian National Health System (INHS).Segments represent profiles of patients requiring different strategies for delivering health services. Their knowledge and analysis might support an effort to build an effective population-based medicine approach.
Source: BMC Health Services Research - December 21, 2012 Category: Journals (General) Authors: Federico LegaAlessandro Mengoni Source Type: research

Stigma, an important source of dissatisfaction of health workers in HIV response in Vietnam: a qualitative study
Conclusion: This study confirmed the relationship between stigmatization of PLHIV and stigma experienced by staff because of association with PLHIV from families, colleagues, and society. The experiencing stigma results in additional work-related stress, low self-esteem, poor views of their profession, and lower income. The study shows the importance of actions to improve staff job satisfaction such as pay raises, supportive supervision, stress management, stigma reduction and workplace safety. Immediate actions could be the provision of more information; education and communication in mass media to improve the public imag...
Source: BMC Health Services Research - December 21, 2012 Category: Journals (General) Authors: Ha PhamMyroslava ProtsivMattias LarssonHien HoDaniel VriesAnna Thorson Source Type: research

Patient characteristics associated with hospitalisations for ambulatory care sensitive conditions in Victoria, Australia
We examined the association between patient characteristics and hospitalisation for ACSCs in the adult and paediatric population in Victoria, Australia, 2003/04. Methods: Hospital admissions data were merged with two area-level socioeconomic indexes: Index of Socio-Economic Disadvantage (IRSED) and Accessibility/Remoteness Index of Australia (ARIA). Univariate and multiple logistic regressions were performed for both adult (age 18+ years) and paediatric (age
Source: BMC Health Services Research - December 21, 2012 Category: Journals (General) Authors: Zahid AnsariSyed HaiderHumaira AnsariTanyth de GooyerColin Sindall Source Type: research

C‐reactive protein and incidence of type 2 diabetes in the Pizarra study
ConclusionsSubjects with high serum hs‐CRP levels and low serum adiponectin levels have a higher risk of developing type 2 diabetes within five years.
Source: European Journal of Clinical Investigation - December 20, 2012 Category: Journals (General) Authors: Elehazara Rubio‐Martín, Federico Soriguer, Carolina Gutiérrez‐Repiso, Lourdes Garrido‐Sánchez, Marisol S. Ruíz Adana, Eduardo García‐Fuentes, Sonsoles Morcillo, Isabel Esteva, Felipe J Chaves, Gemma Rojo‐Martinez Tags: Original Article Source Type: research

Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances
ConclusionsWe report for the first time the direct relations of VAI with adipose tissue secretion, as well as with functional glycaemic disorders. Because VAI is estimated easily with data obtained in everyday practice, it could be used as an indirect index of adiponectin levels and the risk of impaired glucose metabolism.
Source: European Journal of Clinical Investigation - December 20, 2012 Category: Journals (General) Authors: Nasser M. Al‐Daghri, Omar S. Al‐Attas, Majed S. Alokail, Khalid M. Alkharfy, Paris Charalampidis, Sarantis Livadas, Anastasios Kollias, Shaun Louie Sabico, George P. Chrousos Tags: Original Article Source Type: research

Heinrich Irenaeus Quincke (1842-1922): The Nobel Prize but for the problem of age.
PMID: 23260761 [PubMed - as supplied by publisher]
Source: Presse Medicale - December 20, 2012 Category: Journals (General) Authors: Cozanitis DA Tags: Presse Med Source Type: research

The socio-technical organisation of community pharmacies as a factor in the Electronic Prescription Service Release Two implementation: a qualitative study
Conclusion: We offer a model of different work approaches community pharmacies use to dispense, which suggests that when adopting a core technical element such as the EPS2 system of dispensing there could be variations in its successful adoption. Technically oriented pharmacies might find it easiest to integrate a similar artefact into work practice although needs EPS2 to synchronise effectively with existing technologies. Pharmacies adopting an improvising-approach have the potential to improve how they organise dispensing through EPS2 although they will need to improve how they apply their operating procedures. Socially ...
Source: BMC Health Services Research - December 20, 2012 Category: Journals (General) Authors: Jasmine HarveyAnthony AveryJustin WaringNick Barber Source Type: research

Should Health Organizations Use Web 2.0 Media in Times of an Infectious Disease Crisis? An In-depth Qualitative Study of Citizens’ Information Behavior During an EHEC Outbreak
Conclusions: During an infectious disease outbreak, our small sample of students did not see social media (like Facebook and Twitter) as suitable or reliable sources for communicating information, but primarily viewed them as a tool for communicating with friends. Wikis, however, did fill several information needs, especially when citizens are actively searching for information. For many, source credibility is an important asset of information usefulness. Finally, we provide several general recommendations for communicating with citizens during an infectious disease outbreak.
Source: Journal of Medical Internet Research - December 20, 2012 Category: Journals (General) Authors: Lex van VelsenJulia E.W.C. van Gemert-PijnenDesirée J.M.A. BeaujeanJobke WentzelJim E. van Steenbergen Source Type: research

Sagittal plane gait characteristics in hip osteoarthritis patients with mild to moderate symptoms compared to healthy controls: A cross-sectional study
Background: Existent biomechanical studies on hip osteoarthritic gait have primarily focused on the end stage of disease. Consequently, there is no clear consensus on which specific gait parameters are of most relevance for hip osteoarthritis patients with mild to moderate symptoms. The purpose of this study was to explore sagittal plane gait characteristics during the stance phase of gait in hip osteoarthritis patients not eligible for hip replacement surgery. First, compared to healthy controls, and second, when categorized into two subgroups of radiographic severity defined from a minimal joint space of 2 mm. Methods: S...
Source: BioMed Central - December 20, 2012 Category: Journals (General) Authors: Ingrid EitzenLinda FernandesLars NordslettenMay Arna Risberg Source Type: research

Designing assisted living technologies 'in the wild': preliminary experiences with cultural probe methodology
Conclusions: Cultural probe methods can help build a rich picture of the lives and experiences of older people to facilitate the co-production of assisted living technologies. But their application may be constrained by the participant's physical, mental and emotional capacity. They are most effective when used as a tool to facilitate communication and development of a deeper understanding of older people's needs.
Source: BioMed Central - December 20, 2012 Category: Journals (General) Authors: Joseph WhertonPaul SugarhoodRob ProcterMark RouncefieldGuy DewsburySue HinderTrisha Greenhalgh Source Type: research

Pain drawings in somatoform-functional pain
Background: Pain drawings are a diagnostic adjunct to history taking, clinical examinations, and biomedical tests in evaluating pain. We hypothesized that somatoform-functional pain, is mirrored in distinctive graphic patterns of pain drawings. Our aim was to identify the most sensitive and specific graphic criteria as a tool to help identifying somatoform-functional pain. Methods: We compared 62 patients with somatoform-functional pain with a control group of 49 patients with somatic-nociceptive pain type. All patients were asked to mark their pain on a pre-printed body diagram. An investigator, blinded with regard to the...
Source: BioMed Central - December 20, 2012 Category: Journals (General) Authors: Niklaus EgloffRafael JA CámaraRoland von KänelNicole KlinglerElizabeth MartiMarie-Louise Gander Ferrari Source Type: research

Effect of the bacterium Serratia marcescens SCBI on the longevity and reproduction of the nematode Caenorhabditis briggsae KT0001
Conclusion: S. marcescens SCBI is not highly pathogenic to C. briggsae KT0001 indicating that the entomopathogenicity reported for this association may be beneficial for both the nematode and bacteria. In light of the fact that hitherto conducted experimental tests conform to widely held view that Serratia are highly pathogenic to Caenorhabditis, the absence of a high fitness cost for C. briggsae we report here may indicate that this entomopathogenic association is non-transient suggesting nematode/bacterial associations in the wild may vary greatly. Consequently, broad generalizations about nematode/bacterial associations...
Source: BioMed Central - December 20, 2012 Category: Journals (General) Authors: Jeremiah D LancasterBudour MohammadEyualem Abebe Source Type: research

Physical activity among South Asian women: a systematic, mixed-methods review
Conclusions: Quantitative and qualitative evidence indicate that South Asian women do not perform the recommended level of PA for health benefits. Both types of studies suffer from limitations due to methods of data collection. More research should be dedicated to standardizing objective PA measurement and to understanding how to utilize the resources of the individuals and communities to increase PA levels and overall health of South Asian women.
Source: BioMed Central - December 20, 2012 Category: Journals (General) Authors: Whitney S BabakusJanice L Thompson Source Type: research

Implications of long-term culture for mesenchymal stem cells: genetic defects or epigenetic regulation?
Wolfgang Wagner discusses a recent article in Stem Cell Research & Therapy on the genetic and epigenetic changes in mesenchymal stem cells during culture, and the implications for cell therapy applications.
Source: BioMed Central - December 20, 2012 Category: Journals (General) Authors: Wolfgang Wagner Source Type: research

Zebrafish erythropoiesis and the utility of fish as models of anemia
As part of the Asia-Pacific series, Kulkeaw and Sugiyama review our understanding of erythropoiesis based on studies using zebrafish, and the utility of fish models in human anemia.
Source: BioMed Central - December 20, 2012 Category: Journals (General) Authors: Kasem KulkeawDaisuke Sugiyama Source Type: research

Workplace violence against physician and nurses in Palestinian public hospitals: a cross-sectional study
Conclusions: Healthcare workers are at comparably high risk of violent incidents in Palestinian public hospitals. Decision makers need to be aware of the causes and potential consequences of such events. There is a need for intervention to protect health workers and provide safer hospital workplaces environment. The results can inform developing proper policy and safety measures.
Source: BMC Health Services Research - December 20, 2012 Category: Journals (General) Authors: Mohamad KitanehMotasem Hamdan Source Type: research

VIDEOCARE: Decentralised psychiatric emergency care through videoconferencing
DiscussionResults from the study will be of importance for understanding of how videoconferencing may support proper treatment and high-quality health care services in rural areas for patients in psychiatric emergencies.
Source: BMC Health Services Research - December 20, 2012 Category: Journals (General) Authors: Marianne TrondsenStein BolleGeir StenslandAksel Tjora Source Type: research

The impact of gender and serum estradiol levels on HDL‐mediated reverse cholesterol transport
ConclusionThe results do not support a role for estradiol status or gender in modifying the initial step of RCT as a protective mechanism against cardiovascular disease.
Source: European Journal of Clinical Investigation - December 19, 2012 Category: Journals (General) Authors: Robert M. Badeau, Jari Metso, Petri T. Kovanen, Miriam Lee‐Rueckert, Matti J. Tikkanen, Matti Jauhiainen Tags: Original Paper Source Type: research

[The diabetic foot.]
Abstract These are the guidelines for preventive care, diagnosis and treatment of the diabetic foot syndrome. Diabetic neuropathy, peripheral vascular disease, bone deformity and altered biomechanics are foot-related risk conditions. The position statement is focused on screening methods and recommendations for clinical care for diabetics, who currently have no foot ulcers. A decision pathway is offered with respect to diagnosis and management of diabetic patients at an increased risk or manifest injuries. PMID: 23250452 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - December 19, 2012 Category: Journals (General) Authors: Lechleitner M, Abrahamian H, Francesconi M Tags: Wien Klin Wochenschr Source Type: research

[Gestational diabetes mellitus.]
Abstract Gestational diabetes (GDM) is defined as any degree of glucose intolerance with onset during pregnancy and is associated with increased feto-maternal morbidity as well as long-term complications in mothers and offspring. Women detected to have diabetes early in pregnancy receive the diagnosis of overt, non-gestational, diabetes. GDM is diagnosed by an oral glucose tolerance test (OGTT) or fasting glucose concentrations (> 92 mg/dl). Screening for undiagnosed type 2 diabetes at the first prenatal visit (Evidence level B) is recommended in women at increased risk using standard diagnostic criteria (hig...
Source: Wiener Klinische Wochenschrift - December 19, 2012 Category: Journals (General) Authors: Kautzky-Willer A, Bancher-Todesca D, Pollak A, Repa A, Lechleitner M, Weitgasser R Tags: Wien Klin Wochenschr Source Type: research

[Insulin therapy of diabetes.]
Abstract Hyperglycemia contributes to morbidity and mortality in patients with diabetes. Thus, reaching treatment targets with regard to control of glycemia is a central goal in the therapy of diabetic patients. The present article represents the recommendations of the Austrian Diabetes Association for the practical use of insulin according to current scientific evidence and clinical studies. PMID: 23250454 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - December 19, 2012 Category: Journals (General) Authors: Lechleitner M, Roden M, Weitgasser R, Ludvik B, Fasching P, Hoppichler F, Kautzky-Willer A, Schernthaner G, Prager R, Wascher TC Tags: Wien Klin Wochenschr Source Type: research

[Diabetic neuropathy.]
Abstract These are the guidelines for diagnosis and treatment of diabetic neuropathy. This diabetic late complication comprises a number of mono- and polyneuropathies, plexopathies, radiculopathies and autonomic neuropathy. The position statement summarizes characteristic clinical symptoms and techniques for diagnostic assessment of diabetic neuropathy. Recommendations for the therapeutic management of diabetic neuropathy, especially for the control of pain in sensomotoric neuropathy, are provided. PMID: 23250455 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - December 19, 2012 Category: Journals (General) Authors: Lechleitner M, Abrahamian H, Francesconi M Tags: Wien Klin Wochenschr Source Type: research

[Diabetes in the youth.]
Abstract In contrast to adults Diabetes mellitus type 1 (DMT1) is the most frequent form of diabetes mellitus during childhood and adolescence (> 95 %). After diagnosis, the management of these DMT1-patients should take place in specialized paediatric centres, not in a primary care setting.The lifelong substitution of insulin is the cornerstone of therapy, the form of insulin-therapy should be adapted according to the age of the patient (conventional, intensified or pump therapy). Diabetes education is also an essential part in the management of diabetes patients and their families.The ISPAD (International So...
Source: Wiener Klinische Wochenschrift - December 19, 2012 Category: Journals (General) Authors: Rami-Merhar B, Fröhlich-Reiterer E, Hofer S, Schober E Tags: Wien Klin Wochenschr Source Type: research

[Diabetes mellitus: Definition, classification and diagnosis.]
Abstract ZUSAMMENFASSUNG: Diabetes mellitus bezeichnet eine Gruppe von heterogenen Erkrankungen, deren gemeinsamer Befund die Erhöhung der Blutglukose ist. Die gegenwärtigen Klassifikationen von Diabetes mellitus Typ 1-4 werden beschrieben und die wesentlichen Merkmale von Typ 1 und Typ 2 Diabetes werden zur bessern Unterscheidung dieser Diabetestypen gegenübergestellt. Darüber hinaus werden die Kriterien für die korrekte biochemische Diagnose unter Nüchtern-Bedingungen und im oralen Glukosetoleranz-Test sowie die Anwendung des Hämoglobin A1c (HbA1c) zusammengefasst. Diese Daten bilden die Grundlage der Empf...
Source: Wiener Klinische Wochenschrift - December 19, 2012 Category: Journals (General) Authors: Roden M Tags: Wien Klin Wochenschr Source Type: research

[Antihypertensive therapy in diabetes mellitus : 2012 guidelines of the Austrian diabetes association.]
[Antihypertensive therapy in diabetes mellitus : 2012 guidelines of the Austrian diabetes association.] Wien Klin Wochenschr. 2012 Dec 19; Authors: Schernthaner G, Drexel H, Rosenkranz AR, Schernthaner GH, Watschinger B Abstract Blood pressure lowering is one of the most important interventions for reducing the vascular complications and mortality in patients with diabetes mellitus. Recent studies indicate that the optimal blood pressure level might be in the range between 130-135 mmHg systolic and 80 mmHg diastolic. Lower blood pressure levels (e.g. 120/80 mmHg) can further reduce the risk for stroke an...
Source: Wiener Klinische Wochenschrift - December 19, 2012 Category: Journals (General) Authors: Schernthaner G, Drexel H, Rosenkranz AR, Schernthaner GH, Watschinger B Tags: Wien Klin Wochenschr Source Type: research