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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 24.

Children's conceptions of their parent's lung transplant
There has been no research that has investigated the psychosocial impact on children whose parents have undergone a lung transplant. The aim of this qualitative study was to describe children’s concerns and understandings of their parent’s transplant surgery. Artwork was used as a creative medium to enable children to portray their experiences in a safe, non-threatening environment. This was used as a visual primer for follow-up interviews. All children expressed similar and complementary views about uncertainty and anxiety, separation, disruption to family life, their desire for normality, and the importance o...
Source: Journal of Child Health Care - March 1, 2013 Category: Pediatrics Authors: Fulbrook, P., Leisfield, T., Wiggins, K. Tags: Articles Source Type: research

Stigma, health and incarceration: Turning the tide for children with a parent in prison
Source: Journal of Child Health Care - March 1, 2013 Category: Pediatrics Authors: Dawson, A., Brookes, L., Carter, B., Larman, G., Jackson, D. Tags: Editorial Source Type: research

64 pediatric deaths associated with influenza reported [NEWS AND FEATURES]
Source: AAP News - March 1, 2013 Category: Pediatrics Authors: Bernstein, H. H. Tags: NEWS AND FEATURES Source Type: research

CALL FOR PAPERS: Examination of Basic Nursing Care
Source: Journal of Nursing Scholarship - March 1, 2013 Category: Nursing Authors: Theo van Achterberg Source Type: research

A Systematic Review of the Interventions for Nipple Trauma in Breastfeeding Mothers
ConclusionsConsidering the treatments investigated, the most favorable evidence indicates the use of lanolin alone or in association with breast protection shells and breast milk expressed and rubbed into the nipple and areola after each feeding session. However, the results obtained in this review are inconclusive, indicating the need for further studies in order to clarify the action of breast milk and lanolin on the damaged tissues, as well as studies involving samples representative of the number needed to treat. Clinical RelevanceThis study provides evidence for nursing practice, thus contributing to the improvement o...
Source: Journal of Nursing Scholarship - March 1, 2013 Category: Nursing Authors: Flaviana Vieira, Maria Márcia Bachion, Dálete Delalibera C. F. Mota, Denize Bouttelet Munari Tags: CLINICAL SCHOLARSHIP Source Type: research

Important Considerations When Applying for a Postdoctoral Fellowship
ConclusionsA synthesis of the present data on the postdoctoral fellowship, eligibility criteria, application process, and important considerations was provided. Experiential knowledge from four present postdoctoral fellows was included. The goals, advantages, and disadvantages of the fellowship were discussed. In conclusion, the postdoctoral fellowship was examined to offer important considerations in the decision to pursue this opportunity. Clinical RelevanceThe clinical relevance of this article is related to the training and education of nurses to become the next generation of independent, successful scholars and scient...
Source: Journal of Nursing Scholarship - March 1, 2013 Category: Nursing Authors: Daisy Sherry, Michelle M. Fennessy, Viola G. Benavente, Todd M. Ruppar, Eileen G. Collins Tags: PROFESSION AND SOCIETY Source Type: research

Parental Influences of Sexual Risk Among Urban African American Adolescent Males
ConclusionsThese findings highlight the importance of the parent‐child relationship and the role of parent‐child communication between parents and sons. Further studies are needed to better understand the nature of father‐son communication and develop strategies to help parents communicate effectively with sons. Clinical RelevanceEvidence has shown that African American adolescent males are more likely to engage in high‐risk sexual behaviors. Understanding the sexual risk communication between African American adolescent males and their parents is important to developing strategies in reducing sexual risk behavior.
Source: Journal of Nursing Scholarship - March 1, 2013 Category: Nursing Authors: Allyssa L. Harris, Melissa A. Sutherland, M. Katherine Hutchinson Tags: CLINICAL SCHOLARSHIP Source Type: research

Beliefs About Cervical Cancer and Pap Test: A New Chilean Questionnaire
Conclusions: It was concluded that the CPC‐28 questionnaire will have important implications on research, education, and administration across disciplines. Clinical Relevance: Nursing curricula and healthcare providers must stress the importance and reinforce the importance of prevention of cervical cancer and regular Pap test screenings.
Source: Journal of Nursing Scholarship - March 1, 2013 Category: Nursing Authors: Maria‐Teresa Urrutia, Rosemary Hall Tags: CLINICAL SCHOLARSHIP Source Type: research

Advancing Genomic Research and Reducing Health Disparities: What Can Nurse Scholars Do?
Conclusions: Nurse scholars are capable of employing their expertise in concept analysis to elucidate how race is used as a variable in scientific research, and to use knowledge brokering to delineate how race variables that imply human ancestry could be utilized in genomic research pragmatically in the context of health disparities. Clinical Relevance: In an era of genomic medicine, nurse scholars should recognize and understand the challenges and complexities of genomics and race and their relevance to health care and health disparities.
Source: Journal of Nursing Scholarship - March 1, 2013 Category: Nursing Authors: Cheedy Jaja, Robert Gibson, Shirley Quarles Source Type: research

Topical cyclosporin for atopic keratoconjunctivitis
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Kwanpornsan Kitnet Tags: COCHRANE NURSING CARE CORNER Source Type: research

Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Xu Qian Tags: COCHRANE NURSING CARE CORNER Source Type: research

Effect of cocoa on blood pressure
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Yu Ting Ngo Tags: COCHRANE NURSING CARE CORNER Source Type: research

Corticosteroids for the common cold
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Cui Cui Liu Tags: COCHRANE NURSING CARE CORNER Source Type: research

Painful diabetic neuropathy management
Abstract Diabetic neuropathy is the most common complication of diabetes as it affects a significant number of patients. The management of patients with diabetic neuropathy is complicated by several factors including the varied symptoms and response to the various treatments available. Strict blood glucose control remains the key to the management thus far nonetheless; it is associated with complications such as hypoglycaemia. In order to provide the most up‐to‐date evidence‐based clinical recommendations pertinent to the management of diabetic neuropathy, several databases and clinical practice guidelines were searc...
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Hanan Khalil Tags: COMMENTARY Source Type: research

Working with interpreters: practical advice for use of an interpreter in healthcare
Abstract The aim of this descriptive commentary is to improve communication in healthcare when an interpreter is used by providing practical advice to healthcare staff when they consider using interpreters. This descriptive commentary considered the issues of preparation and implementation of interpretation sessions to reveal the complexities and dilemmas of an effective healthcare encounter with interpreters. Using the design of a discursive paper, this article seeks to explore and position of what is published in the literature on the topic studied and on the basis of previous studies to provide practical advice on the u...
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Emina Hadziabdic, Katarina Hjelm Tags: COMMENTARY Source Type: research

Chest pain in patients with ‘normal angiography’: could it be cardiac?
Abstract Approximately 20% of patients undergoing diagnostic angiography for the evaluation of chest pain are found to have a normal coronary angiogram. Although this finding is generally associated with a low risk of cardiac events, approximately half will continue to experience chest pain over the next 12 months. Therefore, the finding of normal angiography warrants further evaluation of the potential causes for the presenting chest pain if we are to improve the disability suffered by these patients. In this review, the potential non‐cardiac and cardiac causes for the chest pain in patients with normal angiography are ...
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: David P Di Fiore, John F Beltrame Tags: COMMENTARY Source Type: research

Implementing evidence in an onco‐haematology nursing unit: a process of change using participatory action research
ConclusionsThe findings throw light on the process of change in the healthcare sector. The results are useful to modify nursing practice based on evidence.
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Eva Abad‐Corpa, Pilar Delgado‐Hito, Julio Cabrero‐García, Cristobal Meseguer‐Liza, Carmen Lourdes Zárate‐Riscal, Andrés Carrillo‐Alcaraz, José Tomás Martínez‐Corbalán, Amor Caravaca‐Hernández Tags: EVIDENCE UTILISATION Source Type: research

Implementing the best available evidence in early delirium identification in elderly hip surgery patients
ConclusionsThe delirium predictor tool shows promise as a prompt for best practices in prevention of delirium. This study showed a change in delirium rates as a result of its use. Although the results were not statistically significant, they may be clinically meaningful. Comprehensive assessment and implementation planning by a multidisciplinary team contributed to only 56% compliance in use. Despite this low rate, delirium identification rates were higher.
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Kathleen Ann Russell‐Babin, Helen Miley Tags: EVIDENCE UTILISATION Source Type: research

Fall prevention among children in the presence of caregivers in a paediatric ward: a best practice implementation
ConclusionThis project has shown that fall incidents can be reduced when caregivers' awareness of fall prevention measures in the hospital setting were to be improved. The poster on fall prevention has increased caregivers' awareness and reduced inpatient falls in the acute care setting. The pre‐ and post‐implementation audits showed that the presence of a poster on fall prevention to remind parents/caregivers to raise and securely lock the cot rails at all times was effective in reducing the number of falls for children aged 3 years and below. The experience gained from this project was that communication to every sta...
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Yee Ling Geraldine Lee, Wai Kin Yip, Beng Wah Goh, En Ping Jeannie Chiam, Hui Ping Chermaine Ng Tags: EVIDENCE UTILISATION Source Type: research

Nursing inter‐shift handover process in mental health settings: a best practice implementation project
ConclusionThis project had shown that handover sessions can be made effective by translating evidence into practice through ongoing evidence‐based audit. Continuous evidence‐based evaluation, identification and implementation of nursing inter‐shift handover process are imperative to enhance patient safety and service delivery.
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Chee Lien Poh, Rajni Parasuram, Premarani Kannusamy Tags: EVIDENCE UTILISATION Source Type: research

Maintenance of patency of central venous access devices by registered nurses in an acute ambulatory setting: an evidence utilisation project
ConclusionThis project utilised the process of audit, feedback and re‐audit cycle as a strategy to improve clinical practice. It demonstrated the feasibility of translating evidence‐based practice into the clinical setting, with remarkable improvement in maintaining patency of central venous access devices for patient with cancer. Finally, it is evidenced that the commitment and enthusiasm of team members and all the registered nurses in maintaining the patency of central venous access devices were the crucial factors for the success of this project. The support and assistance provided by the stakeholders also played a...
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Lee Moy Chong, Ying Leng Chow, Shu Shya Catherine Kong, Emily Ang Tags: EVIDENCE UTILISATION Source Type: research

Recognition of the health assistant as a delegated clinical role and their inclusion in models of care: a systematic review and meta‐synthesis of qualitative evidence
ConclusionsQualitative meta‐synthesis was performed providing a unique perspective on the role of health assistants and strategies used to include them in models of care. These synthesised findings can be used to guide practice in healthcare organisations considering strategies for implementing the assistant role, or where assistants are currently utilised.
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Zachary Munn, Catalin Tufanaru, Edoardo Aromataris Tags: EVIDENCE SYNTHESIS Source Type: research

Evidence on the shelf? Continuous improvement
Source: International Journal of Evidence-Based Healthcare - March 1, 2013 Category: Nursing Authors: Ruben Zelm Tags: EDITORIAL Source Type: research

Sex, statins, and diabetes (DECEMBER 2012)
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: THACKER, H. L., ROCCO, M. Tags: Letters to the Editor Source Type: research

Bilateral adrenal masses (DECEMBER 2012)
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: ESTEPHAN, M., MOORE, J. Tags: Letters to the Editor Source Type: research

Emergency contraception (NOVEMBER 2012)
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: KAHLENBORN, C., SEVERS, W. B., BATUR, P. Tags: Letters to the Editor Source Type: research

Septic shock: The initial moments and beyond
Our understanding of the pathophysiology and treatment of sepsis has advanced over the last decade, and evidence-based protocols have improved its outcomes. Here, we review its management in the first hours and afterward, including topics of ongoing study and debate.
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: LAM, S. W., BAUER, S. R., GUZMAN, J. A. Tags: Review Source Type: research

Frailty in older adults: Implications for end-of-life care
Frailty has important implications for the care needs of older adults and how those needs are met. By recognizing frailty and measuring it objectively, clinicians can better engage patients and their loved ones in difficult discussions about treatment plans and prognosis, and ultimately deliver better palliative care.
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: KOLLER, K., ROCKWOOD, K. Tags: Review Source Type: research

A 67-year old man with an abdominal aortic aneurysm
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: LaBOON, A., MASTRACCI, T. M. Tags: Personalizing Patient Care Source Type: research

Cervical cancer screening: What's new and what's coming?
In their 2012 guidelines for cervical cancer screening, several organizations call for less-frequent but more-effective screening that incorporates testing for human papillomavirus (HPV). We review these recommendations and the possible future direction of screening.
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: JIN, X. W., LIPOLD, L., McKENZIE, M., SIKON, A. Tags: Review Source Type: research

Reviewers 2012
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Tags: Reviewers 2012 Source Type: research

Sore throat, odynophagia, hoarseness, and a muffled, high-pitched voice
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: LI, C. J., ARONOWITZ, P. Tags: The Clinical Picture Source Type: research

Giant inverted T waves
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: MADHWAL, S., NAGARAJAN, V., UNDERWOOD, D. A. Tags: The Clinical Picture Source Type: research

Introducing two new deputy editors
Source: Cleveland Clinic Journal of Medicine - March 1, 2013 Category: Journals (General) Authors: MANDELL, B. F. Tags: From the Editor Source Type: research

Prevalence and socioeconomic correlates of chronic morbidity among elderly people in Kosovo: a population-based survey
Conclusion: This study provides important evidence on the magnitude and distribution of chronic conditions among the elderly population of Kosovo. Our findings suggest that, in this sample of elderly people from Kosovo, the oldest-old (especially women) and the poor endure the vast majority of chronic conditions. These findings point to the urgent need to establish a social health insurance scheme including the marginalized segments of elderly people in this transitional country.
Source: BMC Geriatrics - March 1, 2013 Category: Geriatrics Authors: Naim JerliuErvin ToçiGenc BurazeriNaser RamadaniHelmut Brand Source Type: research

Corrigendum
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Tags: Corrigendum Source Type: research

High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment
In this study, we enrolled 18 patients (9 females) and 18 sex- and age-matched controls. We found in 21-OHD patients high serum and leukocyte levels of dickkopf-1 (DKK1), a secreted antagonist of the Wnt/β-catenin signaling pathway known to be a key regulator of bone mass. In particular, we demonstrated by flow cytometry, confocal microscopy, and real-time PCR that monocytes, T lymphocytes, and neutrophils from patients expressed high levels of DKK1, which may be related to the cGC therapy. In fact, we showed that dexamethasone treatment markedly induced the expression of DKK1 in a dose- and time-dependent manner in l...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Brunetti, G., Faienza, M. F., Piacente, L., Ventura, A., Oranger, A., Carbone, C., Benedetto, A. D., Colaianni, G., Gigante, M., Mori, G., Gesualdo, L., Colucci, S., Cavallo, L., Grano, M. Tags: Articles Source Type: research

Losartan increases muscle insulin delivery and rescues insulin's metabolic action during lipid infusion via microvascular recruitment
Insulin delivery and transendothelial insulin transport are two discrete steps that limit muscle insulin action. Angiotensin II type 1 receptor (AT1R) blockade recruits microvasculature and increases glucose use in muscle. Increased muscle microvascular perfusion is associated with increased muscle delivery and action of insulin. To examine the effect of acute AT1R blockade on muscle insulin uptake and action, rats were studied after an overnight fast to examine the effects of losartan on muscle insulin uptake (protocol 1), microvascular perfusion (protocol 2), and insulin's microvascular and metabolic actions in the state...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Wang, N., Chai, W., Zhao, L., Tao, L., Cao, W., Liu, Z. Tags: Articles Source Type: research

Disruption of claudin-18 diminishes ovariectomy-induced bone loss in mice
Claudin-18 (Cldn-18), a member of the tight junction family of proteins, is a negative regulator of RANKL-induced osteoclast differentiation and bone resorption (BR) in vivo. Since estrogen deficiency decreases bone mass in part by a RANKL-mediated increase in BR, we evaluated whether estrogen regulates Cldn-18 expression in bone. We found that Cldn-18 expression was reduced in the bones of estrogen deficient mice, whereas it was increased by estrogen treatment in osteoblasts and osteoclasts in vitro. We next evaluated the role of Cldn-18 in mediating estrogen-induced bone loss. Cldn-18 knockout (KO) and littermate wild-ty...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Kim, H.-Y., Alarcon, C., Pourteymour, S., Wergedal, J. E., Mohan, S. Tags: Articles Source Type: research

Estimating the risk after gestational diabetes mellitus: can we improve the information from the postpartum OGTT?
Risk stratification after pregnancy with gestational diabetes mellitus (GDM) is based on screening with the 2-h oral glucose tolerance test (OGTT). Actually, prediabetes and diabetes are diagnosed by impaired fasting [fasting plasma glucose (FPG)] and 120 min-postload glucose levels (120'-PLG). We hypothesized that the clinical information could be improved by including measurements at different time points from the OGTT in the medical decision-making process. One hundred ten women with previous gestational diabetes (pGDM) and 41 controls were included 3–6 mo after delivery and underwent specific metabolic assessment...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Gobl, C. S., Bozkurt, L., Prikoszovich, T., Tura, A., Pacini, G., Kautzky-Willer, A. Tags: Articles Source Type: research

Reductions in insulin concentrations and {beta}-cell mass precede growth restriction in sheep fetuses with placental insufficiency
In pregnancy complicated by placental insufficiency (PI) and intrauterine growth restriction (IUGR), the fetus near term has reduced basal and glucose-stimulated insulin concentrations and reduced β-cell mass. To determine whether suppression of insulin concentrations and β-cell mass precedes reductions in fetal weight, which would implicate insulin deficiency as a cause of subsequent IUGR, we measured basal and glucose-stimulated insulin concentrations and pancreatic histology at 0.7 gestation in PI fetuses. Placental weights in the PI pregnancies were 40% lower than controls (265 ± 26 vs. 442 ± 41...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Limesand, S. W., Rozance, P. J., Macko, A. R., Anderson, M. J., Kelly, A. C., Hay, W. W. Tags: Articles Source Type: research

{beta}-Adrenergic signaling stimulates osteoclastogenesis via reactive oxygen species
Sympathetic signaling regulates bone resorption through receptor activator of nuclear factor-B ligand (RANKL) expression via the β-adrenergic receptor (β-AR) on osteoblasts. Reactive oxygen species (ROS) are known as one type of osteoclast regulatory molecule. Here we show that an antioxidant, α-lipoic acid (α-LA), treatment prevent the β-adrenergic signaling-induced bone loss by suppressing osteoclastogenesis, and sympathetic signaling directly regulates osteoclastogenesis through β2-AR expressed on osteoclasts via intracellular ROS generation. In an in vitro study, the β-AR agonist is...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Kondo, H., Takeuchi, S., Togari, A. Tags: Articles Source Type: research

Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system
Ectopic expression of uncoupling protein 1 (UCP1) in skeletal muscle (SM) mitochondria increases lifespan considerably in high-fat diet-fed UCP1 Tg mice compared with wild types (WT). To clarify the underlying mechanisms, we investigated substrate metabolism as well as oxidative stress damage and antioxidant defense in SM of low-fat- and high-fat-fed mice. Tg mice showed an increased protein expression of phosphorylated AMP-activated protein kinase, markers of lipid turnover (p-ACC, FAT/CD36), and an increased SM ex vivo fatty acid oxidation. Surprisingly, UCP1 Tg mice showed elevated lipid peroxidative protein modificatio...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Keipert, S., Ost, M., Chadt, A., Voigt, A., Ayala, V., Portero-Otin, M., Pamplona, R., Al-Hasani, H., Klaus, S. Tags: Articles Source Type: research

Metabolic programming effects initiated in the suckling period predisposing for adult-onset obesity cannot be reversed by calorie restriction
In this study, calorie restriction by pair-feeding was imposed on HC male rats (HC/PF) to normalize food intake similar to that of mother-fed (MF) rats from weaning until postnatal day 140. A group of HC/PF rats was switched over to ad libitum feeding (HC/PF/AL) from days 90 to 140. Pair-feeding reduced body weight gains and serum insulin and leptin levels in HC/PF rats compared with HC rats, but these parameters were restored to HC levels in the HC/PF/AL rats after ad libitum feeding. Interestingly, the heightened insulin secretory response of isolated islets from adult HC/PF and HC/PF/ AL rats to glucose, acetylcholine, ...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Srinivasan, M., Mahmood, S., Patel, M. S. Tags: Articles Source Type: research

Chronic levothyroxine and acute T3 treatments enhance the amplitude and time course of uterine contractions in human
This study compares the functional consequences of levothyroxine (T4) treatment during pregnancy as well as the acute affects of triiodothyronine (T3) on spontaneous uterine contractile activities observed in vitro. Uterine biopsies were obtained from consenting women undergoing elective caesarean at term (n = 28). Spontaneous contractile activities from T4-treated pregnant women (n = 8) were compared with control patients (n = 20) by isometric tension measurements. Effects of acute T3 and T4 on control tissues were also monitored. Area under the curve, amplitude, time to peak, duration, and frequency were quantified. In u...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Corriveau, S., Pasquier, J.-C., Blouin, S., Bellabarba, D., Rousseau, E. Tags: Articles Source Type: research

Inflammation during obesity is not all bad: evidence from animal and human studies
Chronic inflammation is a characteristic of obesity and is associated with accompanying insulin resistance, a hallmark of type 2 diabetes mellitus (T2DM). Although proinflammatory cytokines are known for their detrimental effects on adipose tissue function and insulin sensitivity, their beneficial effects in the regulation of metabolism have not drawn sufficient attention. In obesity, inflammation is initiated by a local hypoxia to augment angiogenesis and improve adipose tissue blood supply. A growing body of evidence suggests that macrophages and proinflammatory cytokines are essential for adipose remodeling and adipocyt...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Ye, J., McGuinness, O. P. Tags: Reviews Source Type: research

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications
Skeletal muscles contain resident immune cell populations and their abundance and type is altered in inflammatory myopathies, endotoxemia or different types of muscle injury/insult. Within tissues, monocytes differentiate into macrophages and polarize to acquire pro- or anti-inflammatory phenotypes. Skeletal muscle macrophages play a fundamental role in repair and pathogen clearance. These events require a precisely regulated cross-talk between myofibers and immune cells, involving paracrine/autocrine and contact interactions. Skeletal muscle also undergoes continuous repair as a result of contractile activity that involve...
Source: AJP: Endocrinology and Metabolism - March 1, 2013 Category: Endocrinology Authors: Pillon, N. J., Bilan, P. J., Fink, L. N., Klip, A. Tags: Reviews Source Type: research

Combination of a GnRH agonist with an antagonist prevents flare-up effects and protects primordial ovarian follicles in the rat ovary from cisplatin-induced toxicity: a controlled experimental animal study
Conclusions: The combination of a GnRH agonist with antagonist completely prevented the flare-up effect and enhanced the protective effect of the ovary from cisplatin-induced gonadotoxicity in rats.
Source: Reproductive Biology and Endocrinology - March 1, 2013 Category: Endocrinology Authors: Xiaoyan LiXiang KangQingchun DengJing CaiZehua Wang Source Type: research

Variation of C peptide decay rate in diabetic patients with positive glutamic acid decarboxylase antibody: better discrimination with initial fasting C peptide
Conclusions: Initial level of fasting C peptide is a good indicator for predicting beta cell function failure in GAD-Ab positive diabetic patients.
Source: BMC Endocrine Disorders - March 1, 2013 Category: Endocrinology Authors: Xia LiGan HuangJian LinLin YangZhiguang Zhou Source Type: research

When less is more for patients in laboratory testing.
PMID: 23429361 [PubMed - in process]
Source: American Journal of Clinical Pathology - March 1, 2013 Category: Pathology Authors: Hilborne LH Tags: Am J Clin Pathol Source Type: research