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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 29.

Neck muscle cross-sectional area, brain volume and cognition in healthy older men; a cohort study
Conclusions: In healthy older men, preservation of whole brain volume (i.e. less atrophy) is associated with larger muscle size. Longitudinal ageing studies are now required to investigate these relationships further.
Source: BMC Geriatrics - February 28, 2013 Category: Geriatrics Authors: Alixe KilgourKaren FergusonCalum GrayIan DearyJoanna WardlawAlasdair MacLullichJohn Starr Source Type: research

The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults
Background: Aging and physical inactivity are associated with declines in some cognitive domains and cerebrovascular function, as well as an elevated risk of cerebrovascular disease and other morbidities. With the increase in the number of sedentary older Canadians, promoting healthy brain aging is becoming an increasingly important population health issue. Emerging research suggests that higher levels of physical fitness at any age are associated with better cognitive functioning and this may be mediated, at least in part, by improvements in cerebrovascular reserve. We are currently conducting a study to determine: if a s...
Source: BMC Geriatrics - February 28, 2013 Category: Geriatrics Authors: Amanda TyndallMargie DavenportBen WilsonGrazyna BurekGenevieve Arsenault-LapierreEryka HaleyGail EskesChristine FriedenreichMichael HillDavid HoganR LongmanTodd AndersonRichard LeighEric SmithMarc Poulin Source Type: research

Clinical implication of hypovascular hepatocellular carcinoma studied in 4,474 patients with solitary tumour equal or less than 3 cm
ConclusionsHypovascular HCC was biologically less aggressive and developed with stepwise dedifferentiation and transformation to hypervascular appearance along with tumour growth. These results will help in leading correct diagnosis of small hypovascular tumour and assessing optimal treatment for hypovascular HCC≤3 cm.
Source: Liver International - February 28, 2013 Category: Gastroenterology Authors: Kenichi Takayasu, Shigeki Arii, Michiie Sakamoto, Yutaka Matsuyama, Masatoshi Kudo, Takafumi Ichida, Osamu Nakashima, Osamu Matsui, Namiki Izumi, Yonson Ku, Norihiro Kokudo, Masatoshi Makuuchi, Tags: Liver Cancer Source Type: research

Do the digestive tract symptoms in eating disorder patients represent functional gastrointestinal disorders?
Conclusions: The GI symptoms common in eating disorder patients very likely represent the same FGIDs that occur in non-ED patients. Symptoms of pelvic floor dysfunction in the absence of functional constipation, however, are prominent in eating disorder patients. Further investigation of the items comprising the 'pelvic floor dysfunction' factor in other patient populations may yield useful results.
Source: BMC Gastroenterology - February 28, 2013 Category: Gastroenterology Authors: Suzanne AbrahamJohn Kellow Source Type: research

Cost and burden of gastroesophageal reflux disease among patients with persistent symptoms despite proton pump inhibitor therapy: an observational study in France: burden of GERD in partial PPI responders in France
Conclusions: Partial response to PPI therapy for GERD is associated with a high symptom burden, significant impairment of HRQL and work productivity, and substantial GERD-related costs.
Source: BMC Gastroenterology - February 28, 2013 Category: Gastroenterology Authors: Stanislas des VarannesHelena LöfmanMaria KarlssonPeter WahlqvistMagnus RuthMary FurstnauNicolas DespiégelNils-Olov Stålhammar Source Type: research

Trace gluten contamination may play a role in mucosal and clinical recovery in a subgroup of diet-adherent non-responsive celiac disease patients
Conclusions: The GCED may be an effective therapeutic option for GFD-adherent NRCD patients. Response to this diet identifies a subgroup of patients, previously classified as RCD1, that is not truly refractory to dietary treatment. Preventing an inaccurate diagnosis of RCD1 avoids immunotherapy. Most patients are able to return to a traditional GFD without return of symptoms.
Source: BMC Gastroenterology - February 28, 2013 Category: Gastroenterology Authors: Justin HollonPamela CuretonMargaret MartinElaine PuppaAlessio Fasano Source Type: research

Latent autoimmune diabetes in adults (LADA) in Asians: similarities and differences between east and west
Abstract Diabetes is a continuous spectrum with type 1 diabetes (T1D) in one end and type 2 diabetes (T2D) in the other end. Latent autoimmune diabetes in adults (LADA) is T‐cell mediated autoimmune diabetes with the features of both T1D and T2D and in the middle of the diabetes spectrum. Scientists clash on the question of whether this subtype of diabetes is a unique diabetes subtype. Multicenter studies were carried out in different countries including National Diabetes Program (KNDP) collaboratory Group in Korea, Ehime study in Japan, Not Insulin‐Requiring Autoimmune Diabetes (NIRAD) Study in Italy, Nord‐Trøndela...
Source: Journal of Diabetes - February 28, 2013 Category: Endocrinology Authors: Yufei Xiang, Chao Deng, Zhiguang Zhou Tags: Review Article Source Type: research

Implications of new European Union driving regulations on patients with Type 1 diabetes who participated in the Diabetes Control and Complications Trial
ConclusionsMore than one episode of severe hypoglycaemia within a year was a frequent event in subjects in the Diabetes Control and Complications Trial, especially in intensively treated patients. If applied to current practice, improving road safety through these changes to European Union regulations could have a substantial impact on drivers who have Type 1 diabetes. This emphasizes the need to take into account the potential effects of severe hypoglycaemia in those who rely on a driving licence.
Source: Diabetic Medicine - February 28, 2013 Category: Endocrinology Authors: E. S. Kilpatrick, A. S. Rigby, R. E. Warren, S. L. Atkin Tags: Short Report: Care Delivery Source Type: research

Synthesis, Cytotoxicity, and Apoptosis Induction Study of Antitumor Dinuclear Platinum(II) Complexes
Abstract Five novel dinuclear platinum(II) complexes with a new chiral ligand, 3‐(2‐amino‐cyclohexylamino)‐propionic acid (HP), were designed, prepared and spectrally characterized. The in vitro cytotoxicities of these compounds were evaluated against the HepG‐2, MCF‐7, A549, and HCT‐116 cell lines. The results indicated that all compounds showed cytotoxicity towards the HepG‐2 cell line. Particularly, complex X5, which has SO as a bridge, exhibited better cytotoxicity than carboplatin or oxaliplatin against all selected cell lines. Moreover, double dyeing flow cytometric resection indicated that the target...
Source: Archiv der Pharmazie - February 28, 2013 Category: Drugs & Pharmacology Authors: Gang Xu, Shaohua Gou, Chuanzhu Gao Tags: Full Paper Source Type: research

Synthesis and Evaluation of 1,ω‐Bis(1,2,3,5‐thiatriazol‐5‐yl)alkanes as In Vitro and In Vivo α‐Amylase and Lipase Inhibitors
Abstract Thionyl chloride reacts with 1,ω‐bis‐(1‐tosylamidrazone)alkanes 1 to give a series of 1,ω‐bis‐(4‐alkyl‐2‐tosyl‐1,2,3,5‐thiatriazol‐5‐yl)alkanes 2. All the newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis, and ESI–MS spectral data. All the new compounds were screened for their inhibitory effect on key enzymes related to diabetes and obesity, such as α‐amylase and lipase. In vitro and in vivo studies revealed that these thiatriazole derivatives exert an inhibitory action against these key enzymes. Moreover the administration of these compounds t...
Source: Archiv der Pharmazie - February 28, 2013 Category: Drugs & Pharmacology Authors: Salwa Hamzaoui, Khaled Hamden, Adel Ben Salem, Maxime Mourer, Jean‐Bernard Regnouf‐De‐Vains, Mohamed Kossentini Tags: Full Paper Source Type: research

Erratum
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Source Type: research

News and Notices
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Source Type: research

Dermatology, 2 vol. set, 3rd edn
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: Nick J Levell Tags: Book Review Source Type: research

Incidence and survival in patients with cutaneous malignant melanoma: experience in a U.K. population, 1984–2009
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: H. L. Hunter, O. M. Dolan, E. McMullen, D. Donnelly, A. Gavin Tags: Correspondence Source Type: research

Dose escalation may be effective in patients with psoriasis after treatment failure or suboptimal response, but switching to adalimumab is the most cost‐effective measure in different scenarios
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: L. Puig Tags: Correspondence Source Type: research

The British Medical Journal and prescribing of minocycline for acne
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: C. Moss, R.E. Ferner Tags: Correspondence Source Type: research

Safety and effectiveness of ustekinumab and antitumour necrosis factor therapy in patients with psoriasis and chronic viral hepatitis B or C: a retrospective, multicentre study in a clinical setting
Conclusions Biologic therapy was effective and safe for the majority of our patients with HCV and HBV infection, although there may be a risk of reactivation or aggravation. We describe the first cases to receive ustekinumab. The use of biologics should be limited to those cases in which the risk–benefit ratio is justified.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: R. Navarro, E. Vilarrasa, P. Herranz, L. Puig, X. Bordas, J.M. Carrascosa, R. Taberner, M. Ferrán, M. García‐Bustinduy, A. Romero‐Maté, R. Pedragosa, A. García‐Diez, E. Daudén Tags: THERAPEUTICS Source Type: research

Eczema severity in preadolescent children and its relation to sex, filaggrin mutations, asthma, rhinitis, aggravating factors and topical treatment: a report from the BAMSE birth cohort
Conclusions More preadolescent girls than boys had eczema. FLG mutations did not influence eczema severity in our population‐based cohort. Prevalence of rhinitis and asthma was associated with eczema severity, with the highest prevalence among boys with moderate‐to‐severe eczema.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: N. Ballardini, I. Kull, C. Söderhäll, G. Lilja, M. Wickman, C.F. Wahlgren Tags: PAEDIATRIC DERMATOLOGY Source Type: research

A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions
Conclusions PTs are useful and safe for identifying agents inducing SCAR.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: A. Barbaud, E. Collet, B. Milpied, H. Assier, D. Staumont, M. Avenel‐Audran, A. Grange, S. Amarger, P. Girardin, M.‐T. Guinnepain, F. Truchetet, A. Lasek, J. Waton, Tags: CUTANEOUS ALLERGY Source Type: research

Assessment of skin barrier function in podoconiosis: measurement of stratum corneum hydration and transepidermal water loss
Conclusions Patients with podoconiosis have significantly lower SC hydration in the skin of their lower legs and feet than controls, which may lead to cracking and splitting, and increased risk of lymphoedema and infection.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: J.S. Ferguson, W. Yeshanehe, P. Matts, G. Davey, P. Mortimer, C. Fuller Tags: CLINICAL AND LABORATORY INVESTIGATIONS Source Type: research

Detection of HLA‐B*58:01, the susceptible allele for allopurinol‐induced hypersensitivity, by loop‐mediated isothermal amplification
Conclusions The HLA‐B*58:01 LAMP assay was confirmed to be simple, rapid and specific for the detection of HLA‐B*58:01, and therefore of potential value in the diagnosis of allopurinol‐induced hypersensitivity.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: J. Kwok, K.M. Kwong Tags: CLINICAL AND LABORATORY INVESTIGATIONS Source Type: research

Oestrogen receptor beta and melanoma: a comparative study
Conclusions ERβ expression is inversely associated with Breslow thickness and is significantly influenced by sex in MM.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: V. de Giorgi, A. Gori, S. Gandini, F. Papi, M. Grazzini, S. Rossari, A. Simoni, V. Maio, D. Massi Tags: CLINICAL AND LABORATORY INVESTIGATIONS Source Type: research

Proteasome inhibition as a novel mechanism of the proapoptotic activity of γ‐secretase inhibitor I in cutaneous T‐cell lymphoma
Conclusions GSI‐I represents an interesting drug with a dual mechanism of action comprising inhibition of both Notch and the proteasome.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: E. Biskup, M.R. Kamstrup, V. Manfé, R. Gniadecki Tags: CLINICAL AND LABORATORY INVESTIGATIONS Source Type: research

Stratum basale keratinocyte expression of the cell‐surface glycoprotein CDCP1 during epidermogenesis and its role in keratinocyte migration
Conclusions These findings delineate the expression of CDCP1 in human epidermal keratinocytes during epidermogenesis and demonstrate that CDCP1 is involved in keratinocyte migration.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: J.A. McGovern, J.R. Heinemann, L.J. Burke, R. Dawson, T.J. Parker, Z. Upton, J.D. Hooper, K.J. Manton Tags: CUTANEOUS BIOLOGY Source Type: research

Commentary: BRAF inhibitors for metastatic melanoma
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: M. Marples Tags: PUTTING PAPERS INTO PRACTICE Source Type: research

Response to a costly revolution for a subgroup of patients with metastatic melanoma
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: A. Hauschild Tags: PUTTING PAPERS INTO PRACTICE Source Type: research

A costly revolution for a subgroup of patients with metastatic melanoma
This report is based on the cut‐off date of 19 December 2011. Patients with previously untreated stage IV or unresectable stage III BRAF (V600)‐mutated melanoma were randomly assigned (3:1) to receive dabrafenib (150 mg twice daily, orally) or dacarbazine (1000 mg m−2 intravenously every 3 weeks). Patients were stratified according to American Joint Committee on Cancer stage. The primary endpoint was investigator‐assessed progression‐free survival (PFS) and was analysed by intention to treat. Safety was assessed per protocol. Findings Of the 733 patients screened, 250 were randomly assigned to receive ...
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: A.C.J. van Akkooi, T. Nijsten Tags: PUTTING PAPERS INTO PRACTICE Source Type: research

Photodynamic therapy of infected ulcers
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: H. C. Wulf, T. Karlsmark Tags: COMMENTARIES Source Type: research

Supra‐ultraviolet hits sunbed seekers
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: P. Wolf Tags: COMMENTARIES Source Type: research

Allergy workup of severe cutaneous adverse drug reactions: a light at the end of the tunnel?
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: B. Schnyder, G. Porebski, W.J. Pichler Tags: EDITORIAL Source Type: research

Treatment of severe psoriasis with biological therapies in patients with viral hepatitis B and C
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: R.B. Warren, A. Al‐Ri Fai Tags: EDITORIAL Source Type: research

March 2013
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Tags: Editor's Choice Source Type: research

Platelet activation: A link between psoriasis per se and subclinical atherosclerosis; Case‐control study
ConclusionOur study showed increased atherosclerosis risk in psoriatic patients; particularly those with moderate/severe disease, as evidenced by increased expression of platelet CD62 compared with healthy controls. Moreover, we found positive correlation between CD62 expression and ARD (another possible marker of atherosclerosis) with positive correlation to Psoriasis Area and Severity Index (PASI) score; the most important factor influencing CD62 expression. However, our data as regard MPV and FMD does not support using either to diagnose subclinical atherosclerosis in psoriatics, for further studies.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: H.M.A. Saleh, E.A.S. Attia, A.M. Onsy, A.A. Saad, M.M.M. Abd Ellah Tags: Original Article Source Type: research

Linear immunoglobulin‐A bullous dermatosis complicating multi‐organ tuberculosis at early stage treatment
We report a case of LAD concomitant with early‐stage treatment of tuberculosis, raising the question of the triggering role of drugs or tuberculosis itself.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: C. Morice, G. Monsel, M. Lafaurie, M. Battistella, J.R. Manciet, M. Bagot, A. Petit, M. Viguier Tags: Correspondence Source Type: research

Discoid Lupus Alopecia Complicated by Frontal Fibrosing Alopecia on a Background of AGA
Abstract Madam, The cicatricial alopecias have been the subject of much debate regarding their correct classification based on clinical and histopathological features. Discoid cutaneous lupus erythematosus (DLE) and lichenplanopilaris (LPP) are amongst the most common forms of scarring alopecia. These entities may be difficult to distinguish both clinically and histologically and the finding of corroboratory skin lesions elsewhere on the body is seen as a strong pointer towards the correct diagnosis.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: D.C. Gaffney, R.D. Sinclair, S. Yong‐Gee Tags: Correspondence Source Type: research

Digital Necrosis from Dandelion Tea
We report a patient with renal impairment who developed hyperoxalaemia causing peripheral gangerene due to the ingestion of large quantities of dandelion tea.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: B. Moriarty, J.H. Pinney, M.P. Owen‐Casey, M.H.A. Rustin, F. Deroide, C. Laing, A. Davenport Tags: Correspondence Source Type: research

Loss‐of‐function mutation in AAGAB gene in Chinese families with punctuate palmoplantar keratoderma
ConclusionsA novel loss‐of‐function mutation within the AAGAB gene associated with PPPK was identified from 2 Chinese pedigrees.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: M. Li, L. Yang, H. Shi, B. Guo, X. Dai, Z. Yao, G. Zhang Tags: Concise Communication Source Type: research

The surface area of the hand and the palm for estimating percent of total body surface area: results of a meta‐analysis
ConclusionThe use of HSA equating to 1% TBSA results in an over‐estimate for adults (particularly women) and an under‐estimate for children. PSA equating to 0·5% TBSA appears to be suitable for adults. Patient variables including gender and body mass index result in variation of HSA as%TBSA.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: J. Rhodes, C. Clay, M. Phillips Tags: Original Article Source Type: research

No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia
Androgenetic alopecia (AGA) is a common age‐dependent trait, characterised by a progressive loss of hair from the scalp. The hair loss may commence during puberty and up to 80% of Caucasian men experience some degree of AGA throughout their lifetime1. Research has established that two essential aetiological factors for AGA are a genetic predisposition and the presence of androgens (male sex hormones)1,2. A recent meta‐analysis of genome‐wide association studies (GWAS) has increased the number of identified loci associated with this trait at the molecular level to a total of eight3
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: S. Heilmann, D.R. Nyholt, F.F. Brockschmidt, A.M. Hillmer, C. Herold, , T. Becker, N.G. Martin, M.M. Nöthen Tags: Correspondence Source Type: research

Autosomal recessive isolated familial acanthosis nigricans in a Pakistani family due to a homozygous mutation in the insulin receptor gene
Acanthosis nigricans (AN) is characterized by non‐inflamed, thick, brown‐black pigmentation of the epidermis of the neck, dorsal hands and feet, axilla, umbilicus, knees, and elbows. It has been reported in both inherited as well as acquired forms (e.g., as a paraneoplastic syndrome). Most cases of AN have been described in association with insulin resistance syndromes and fibroblast growth factor receptor (FGFR) mutations. However, it also occurs as a symptom of diverse syndromes, including leprechaunism, Rabson‐Mendenhall syndrome, and thanatophoric dysplasia
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: S. Ahmad, H. Mahmoudi, M. Naeem, R.C. Betz Tags: Correspondence Source Type: research

Eyebrow alopecia: Centrofacial trichoblastomatosis
We report the case of a 21‐year‐old caucasian female who presented to our clinic complaining about progressive, bilateral eyebrow loss which had been developing for the previous 18 months. Even though the patient was otherwise asymptomatic, she admitted a cosmetic concern. Her past medical history as well as that of her family were both unremarkable. She had been diagnosed with folliculitis by her general practitioner, having been placed on minocycline 100mg daily during 3 months to no avail. On physical examination, skin‐colored papules on both medial thirds of her eyebrows could be observed.
Source: British Journal of Dermatology - February 28, 2013 Category: Dermatology Authors: M. Galán‐Gutierrez, R. Ruiz‐Villaverde, D. Sánchez‐Cano, A. Sánz‐Trelles Tags: Correspondence Source Type: research

Multilevel factors associated with dentists’ counseling of pregnant women about periodontal health
ConclusionsDentists who were knowledgeable about periodontal disease were more likely to counsel pregnant patients. Future interventions should improve the oral health knowledge of dentists and other healthcare professionals regarding the importance of comprehensive dental care, including periodontal treatment when needed, for all pregnant patients.
Source: Special Care in Dentistry - February 28, 2013 Category: Dentistry Authors: Donald L. Chi, Peter Milgrom, Adam C. Carle, Colleen E. Huebner, Lloyd A. Mancl Tags: Article Source Type: research

Oral myiasis: a case report
We present a case report of oral myiasis in a 22‐year‐old male with cerebral palsy and severe mental retardation treated successfully by manual removal of the larvae by topical application of turpentine oil and oral systemic therapy with ivermectin.
Source: Special Care in Dentistry - February 28, 2013 Category: Dentistry Authors: Jane Emily Zachariah, Khushboo Sehgal, Uma B. Dixit, Rupinder Bhatia Tags: Case History Report Source Type: research

Marfan syndrome: a review of the literature and case report
This report emphasizes the orofacial findings in MFS and highlights particularities of dental treatment when social deficits and intellectual disabilities are also implicated.
Source: Special Care in Dentistry - February 28, 2013 Category: Dentistry Authors: Annetta K. L. Tsang, Aart Taverne, Trevor Holcombe Tags: Case History Report Source Type: research

Effects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implants
ConclusionsAnalysis of the data presented suggests that CS partially impairs the osseointegration of tibial implants and that ALN therapy is able to prevent these negative effects.
Source: Clinical Implant Dentistry and Related Research - February 28, 2013 Category: Dentistry Authors: Nicolau Conte Neto, Cleverton Roberto Andrade, Luis Carlos Spolidorio, Cleópatra da Silva Planeta, Fábio Cardoso Cruz, Alliny Souza Bastos, Elcio Marcantonio Tags: Original Article Source Type: research

Pharmacodynamic Impacts of Proton Pump Inhibitors on the Efficacy of Clopidogrel In Vivo—A Systematic Review
ConclusionsConcomitant use of a PPI with clopidogrel attenuated the antiplatelet effect of clopidogrel, but may be clinically unimportant because there were no clinical differences in the risk for major adverse cardiovascular events.Additional Supporting Information may be found in the online version of this article.The authors have no funding, financial relationships, or conflicts of interest to disclose.
Source: Clinical Cardiology - February 28, 2013 Category: Cardiology Authors: Jie Chen, Shi‐yao Chen, Jing‐jing Lian, Xiao‐qing Zeng, Tian‐cheng Luo Tags: Review Source Type: research

Conveying genomic recurrence risk estimates to patients with early‐stage breast cancer: oncologist perspectives
ConclusionOncologists noted several benefits of testing and also many challenges, despite wide dissemination and common use. Education for health providers should include specific training in how to interpret and communicate the uncertainty inherent in genomic tests while integrating patient preferences to inform treatment decision making. Copyright © 2013 John Wiley & Sons, Ltd.
Source: Psycho-Oncology - February 28, 2013 Category: Cancer & Oncology Authors: Elizabeth Spellman, Nadiyah Sulayman, Susan Eggly, Beth N. Peshkin, Claudine Isaacs, Marc D. Schwartz, Suzanne C. O'Neill Tags: Paper Source Type: research

An assessment of feeding jejunostomy tube placement at the time of resection for gastric adenocarcinoma
ConclusionJ‐tube placement after gastrectomy for gastric cancer may be associated with increased postoperative complications with no demonstrable advantage in receiving adjuvant therapy. Routine use of J‐tubes after subtotal gastrectomy may not be justified, but may be selectively indicated in patients undergoing total gastrectomy. A prospective trial is needed to validate these results. J. Surg. Oncol © 2013 Wiley Periodicals, Inc.
Source: Journal of Surgical Oncology - February 28, 2013 Category: Cancer & Oncology Authors: Sameer H. Patel, David A. Kooby, Charles A. Staley, Shishir K. Maithel Tags: Research Article Source Type: research

The VEGF receptor, neuropilin‐1 (NRP1) represents a promising novel target for chronic lymphocytic leukemia patients
In conclusion, NRP1 might represent an interesting link between angiogenesis and tolerance mechanisms and represents interesting target for therapy. © 2013 Wiley Periodicals, Inc.
Source: International Journal of Cancer - February 28, 2013 Category: Cancer & Oncology Authors: Agnieszka Piechnik, Anna Dmoszynska, Marcin Omiotek, Radosław Mlak, Małgorzata Kowal, Stephan Stilgenbauer, Lars Bullinger, Krzysztof Giannopoulos Tags: Cancer Therapy Source Type: research

Chondroblastoma associated with aneurysmal cyst of the navicular bone: a case report
We describe a case of navicular chondroblastoma case associated with an aneurysmal bone cyst. Treatment consisted of aggressive curettage, phenolization, and bone allograft. The patient was able to resume normal activities after treatment, and there was no recurrence of the chondroblastoma during a follow-up of 3 years.
Source: World Journal of Surgical Oncology - February 28, 2013 Category: Cancer & Oncology Authors: Fang ZhenhuaChen Ming Source Type: research