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This page shows you the most recent publications within this specialty of the MedWorm directory.

Micro‐community cytometry: sensing changes in cell health and glycoconjugate expression by imaging and flow cytometry
Summary Discerning the extent of biologically relevant heterogeneity presents unique challenges to both microscopy and flow cytometry. Micro‐environmental influences and stochastic changes in cellular behaviour can act to mask the origins of both progression and therapeutic resistance in tumour cell systems. In part the dimensionality of different and frequently metastable states can be assessed by multi‐parameter flow cytometry with unparalleled statistical robustness. Complementary application of imaging can provide valuable insights into the complex temporal changes that can occur in cell micro‐communities either ...
Source: Journal of Microscopy - June 14, 2013 Category: Laboratory Medicine Authors: PAUL J. SMITH, ROBERT A. FALCONER, RACHEL J. ERRINGTON Tags: Invited Review Source Type: research

Implementing genomic medicine in pathology.
Abstract The finished sequence of the Human Genome Project, published 50 years after Watson and Crick's seminal paper on the structure of DNA, pushed human genetics into the public eye and ushered in the genomic era. A significant, if overlooked, aspect of the race to complete the genome was the technology that propelled scientists to the finish line. DNA sequencing technologies have become more standardized, automated, and capable of higher throughput. This technology has continued to grow at an astounding rate in the decade since the Human Genome Project was completed. Today, massively parallel sequencing, or nex...
Source: Adv Data - June 14, 2013 Category: Epidemiology Authors: Williams ES, Hegde M Tags: Adv Anat Pathol Source Type: research

Lack of efficacy during the switch from brand to generic allopurinol
In conclusion, even if generic formulations are considered to have the same effects in comparison to the brand one, more data are necessaries in order to well define their effectiveness and rationale use. (Source: Journal of Forensic and Legal Medicine)
Source: Journal of Forensic and Legal Medicine - June 14, 2013 Category: Forensic Medicine Authors: Antonio De Vuono, Francesca Scicchitano, Caterina Palleria, Emilio Russo, Giovambattista De Sarro, Luca Gallelli Tags: Case Reports Source Type: research

Comparative effect of clopidogrel and aspirin versus aspirin alone on laboratory parameters: a retrospective, observational, cohort study
Conclusion: Our findings suggested that hematological adverse effects may be greater with combination therapy of clopidogrel plus aspirin than with aspirin monotherapy. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 14, 2013 Category: Cardiology Authors: Yasuo TakahashiYayoi NishidaTomohiro NakayamaSatoshi Asai Source Type: research

Dentin erosion by whitening mouthwash associated to toothbrushing abrasion: A focus variation 3D scanning microscopy study
ABSTRACT The aim of this study was to determine the erosive potential of hydrogen peroxide (HP) containing mouthwash on dentin assessed by Focus variation three‐dimensional (3D) microscopy. Twenty dentin slabs were selected and randomly allocated into two groups (n = 10): DW—Distilled water (pH = 7.27) and HP—1.5% (pH = 3.78). Each specimen was cyclically demineralized (4 × 60 s/day, 10 days) with HP or DW and brushed 3×/day (200 g, 150 strokes—toothpaste with 1,450 ppmF as NaF). Between the challenges, the specimens were exposed to artificial saliva. Afterward, dentin loss was analyzed using focus variation 3D m...
Source: Microscopy Research and Technique - June 14, 2013 Category: Laboratory Medicine Authors: Juliana P.M. Lima, Mary A.S. Melo, Vanara F. Passos, CÍcero L.N. Braga, Lidiany K.A. Rodrigues, SÉrgio L. Santiago Tags: Research Article Source Type: research

Microstructural characterization of Ti‐6Al‐4V alloy subjected to the duplex SMAT/plasma nitriding
In this study, microstructural characterization of Ti‐6Al‐4V alloy, subjected to the duplex surface mechanical attrition treatment (SMAT)/nitriding treatment, leading to improve its mechanical properties, was carried out through novel and original samples preparation methods. Instead of acid etching which is limited for morphological characterization by scanning electron microscopy (SEM), an original ion polishing method was developed. Moreover, for structural characterization by transmission electron microscopy (TEM), an ion milling method based with the use of two ions guns was also carried out for cross‐section pr...
Source: Microscopy Research and Technique - June 14, 2013 Category: Laboratory Medicine Authors: Y. Pi, J. Faure, G. Agoda‐Tandjawa, C. Andreazza, S. Potiron, A. Levesque, C. Demangel, D. Retraint, H. Benhayoune Tags: Research Article Source Type: research

Biomechanical analysis of the anterior cruciate ligament deficiency in the transverse plane. A laboratory in vivo controlled study.
CONCLUSIONS: Torque curve analysis identified a distinctive pattern comparing ACLd and control groups. The crossover showed a dual behaviour with an initial avoidance pattern followed by reinforcement in the last third of the turn. The pivoting-vertical-jump showed an avoidance pattern significant in a small portion of the middle stance. Despite the tendency towards an increase in the tibial internal rotation, a dynamic rotational instability was not detected. PMID: 23757660 [PubMed - in process] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Ferrer A, Chukwumerije K, Twycross-Lewis R, Woledge R, Morrissey D, Maffulli N Tags: Br J Sports Med Source Type: research

Acute effects of muscle massage previous to strength training on biochemical markers of delayed onset muscle soreness.
CONCLUSIONS: The presents results suggest that delayed onset muscle soreness induced by two classical strength training exercises, is not prevented or attenuated by muscle massage before exercise. PMID: 23757681 [PubMed - in process] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Garrido N, Oliveira G, Mendes R, Sousa N, Sousa M Tags: Br J Sports Med Source Type: research

Spin exchange optical pumping based polarized He filling station for the Hybrid Spectrometer at the Spallation Neutron Source
C. Y. Jiang, X. Tong, D. R. Brown, H. Culbertson, M. K. Graves-Brook et al. The Hybrid Spectrometer (HYSPEC) is a new direct geometry spectrometer at the Spallation Neutron Source at the Oak Ridge National Laboratory. This instrument is equipped with polarization analysis capability with 60 degrees horizontal and 15 degrees vertical detector coverages. In order to provide ... [Rev. Sci. Instrum. 84, 065108 (2013)] published Thu Jun 13, 2013. (Source: Review of Scientific Instruments)
Source: Review of Scientific Instruments - June 13, 2013 Category: Physics Source Type: research

Architecture, implementation, and testing of a multiple-shell gas injection system for high current implosions on the Z accelerator
Mahadevan Krishnan, Kristi Wilson Elliott, Robert E. Madden, P. L. Coleman, John R. Thompson et al. Tests are ongoing to conduct ~20 MA z-pinch implosions on the Z accelerator at Sandia National Laboratory using Ar, Kr, and D gas puffs as the imploding loads. The relatively high cost of operations on a machine of this scale imposes stringent requirements on the functionality, reliability, and safe ... [Rev. Sci. Instrum. 84, 063504 (2013)] published Mon Jun 10, 2013. (Source: Review of Scientific Instruments)
Source: Review of Scientific Instruments - June 13, 2013 Category: Physics Source Type: research

Magnetic reconnection in a weakly ionized plasma
James E. Leake, Vyacheslav S. Lukin, and Mark G. Linton Magnetic reconnection in partially ionized plasmas is a ubiquitous phenomenon spanning the range from laboratory to intergalactic scales, yet it remains poorly understood and relatively little studied. Here, we present results from a self-consistent multi-fluid simulation of magnetic reconnection in ... [Phys. Plasmas 20, 061202 (2013)] published Thu Jun 13, 2013. (Source: Physics of Plasmas)
Source: Physics of Plasmas - June 13, 2013 Category: Physics Source Type: research

Preface to Special Topic Section: Advances in Magnetic Reconnection Research in Space and Laboratory Plasmas. Part II
Hantao Ji, Yasushi Ono, and Ryoji Matsumoto Abstract not available. [Phys. Plasmas 20, 061101 (2013)] published Tue Jun 11, 2013. (Source: Physics of Plasmas)
Source: Physics of Plasmas - June 13, 2013 Category: Physics Source Type: research

Assessment of the core and support functions of the Integrated Disease Surveillance system in Maharashtra, India
Conclusions: Significant progress has been made in the core and support surveillance functions in Maharashtra, however some challenges exist. Support functions (laboratory, transport and communication equipment's, training, supervision, human and other resources) are particularly weak at the district level. Structural integration and establishing permanent state and district surveillance officer positions at district level will ensure leadership; improve performance; support continuity; and offer sustainability to the program. Institutionalizing the integrated disease surveillance strategy through skills based personnel de...
Source: BMC Public Health - Latest articles - June 13, 2013 Category: Consumer Health News Authors: Revati PhalkeySharvari ShuklaSavita ShardulNutan AshtekarSapna ValsaPradip AwateMichael Marx Source Type: research

Predicting the presence of hepatitis B virus surface antigen in Chinese patients by pathology data mining
Abstract Hepatitis B virus (HBV) is a pathogen of worldwide health significance, associated with liver disease. A vaccine is available, yet HBV prevalence remains a concern, particularly in developing countries. Pathology laboratories have a primary role in the diagnosis and monitoring of HBV infection, through hepatitis B surface antigen (HBsAg) immunoassay and associated tests. Analysis of HBsAg immunoassay and associated pathology data from 821 Chinese patients applied 10‐fold cross‐validation to establish classification decision trees (CDTs), with CDT results used subsequently to develop a logistic regression model...
Source: Journal of Medical Virology - June 13, 2013 Category: Virology Authors: Guifang Shang, Alice Richardson, Michelle E. Gahan, Simon Easteal, Stephen Ohms, Brett A. Lidbury Tags: Research Article Source Type: research

Detection of erythrovirus B19 in thyroidectomy specimens from graves' disease patients: A case–control study
The objective of this study was to investigate whether the presence of EVB19 is more frequent in thyroidectomy specimens of patients undergoing thyroidectomy for Graves' disease (cases) than for multinodular thyroid (controls). Serum and thyroidectomy specimens were prospectively collected from 64 patients referred for total thyroidectomy over a 5‐year period (2007–2011) and were investigated retrospectively and blindly for circulating EVB19 DNA by q‐PCR (Qiagen), and for EVB19 thyrocyte infection by immunochemistry (VP2‐Antibody, Dako). EVB19 serology was also determined. General clinical and laboratory data were ...
Source: Journal of Medical Virology - June 13, 2013 Category: Virology Authors: Cyril Page, Thomas Walter Hoffmann, Nassim Benzerdjeb, Gilles Duverlie, Henri Sevestre, Rachel Desailloud Tags: Research Article Source Type: research

Seroprevalence of Seasonal and Pandemic Influenza A in Kuala Lumpur, Malaysia in 2008–2010
Abstract Relatively little is known about the burden of influenza in tropical countries. The seroprevalence of pandemic influenza A (H1N1) 2009, seasonal H1N1 and H3N2 was determined in Kuala Lumpur, Malaysia. Pre‐ and post‐pandemic residual laboratory sera were tested by hemagglutination‐inhibition. The seroprevalence of A(H1N1)pdm09 increased from 3.7% pre‐pandemic to 21.9% post‐pandemic, giving an overall cumulative incidence of 18.1% (95% CI, 13.8–22.5%), mainly due to increases in those <5, 5–17, and 18–29 years old. In contrast with findings from USA, Europe, and Australia, pre‐existing seropreva...
Source: Journal of Medical Virology - June 13, 2013 Category: Virology Authors: I‐Ching Sam, Robert Shaw, Yoke‐Fun Chan, Poh‐Sim Hooi, Aeron C. Hurt, Ian G. Barr Tags: Research Article Source Type: research

Spectrum of respiratory viruses circulating in eastern India: Prospective surveillance among patients with influenza‐like illness during 2010–2011
Abstract In developing countries, viruses causing respiratory disease are a major concern of public health. During January 2010–December 2011, 2,737 patients with acute respiratory infection from the outpatient departments as well as patients admitted to hospitals were screened for different respiratory viruses. Nasal and or throat swabs were collected and transported to the laboratory where initial screening of influenza A and influenza B viruses was performed. The samples were tested further for influenza C virus, parainfluenza viruses 1–4, human rhinovirus, metapneumovirus and respiratory syncytial virus by conventi...
Source: Journal of Medical Virology - June 13, 2013 Category: Virology Authors: Tapasi Roy Mukherjee, Shampa Chanda, Satarupa Mullick, Papiya De, Malay Dey‐Sarkar, Mamta Chawla‐Sarkar Tags: Research Article Source Type: research

Outcomes of HeartWare Ventricular Assist System support in 141 patients: a single-centre experience [TRANSPLANTATION AND MECHANICAL CIRCULATORY SUPPORT]
CONCLUSIONS The HeartWare system provides a safe and effective circulatory support in a population with a wide range of body surface areas, with a satisfactory actuarial survival time and an improved quality of life. It can be used for univentricular or biventricular support, being implanted into the pericardial space with simplified surgical techniques. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Wu, L., Weng, Y.-G., Dong, N.-G., Krabatsch, T., Stepanenko, A., Hennig, E., Hetzer, R. Tags: TRANSPLANTATION AND MECHANICAL CIRCULATORY SUPPORT Source Type: research

Fluorescence lifetime imaging of lignin autofluorescence in normal and compression wood
Summary Wood cell walls fluoresce as a result of UV and visible light excitation due to the presence of lignin. Fluorescence spectroscopy has revealed characteristic spectral differences in various wood types, notably normal and compression wood. In order to extend this method of characterising cell walls we examined the fluorescence lifetime of wood cell walls using TCSPC (Time‐Correlated Single Photon Counting) as a method of potentially detecting differences in lignin composition and measuring the molecular environment within cell walls. The fluorescence decay curves of both normal and compression wood from pine conta...
Source: Journal of Microscopy - June 13, 2013 Category: Laboratory Medicine Authors: L.A. DONALDSON, K. RADOTIC Tags: Original Article Source Type: research

Multivariate Normally Distributed Biomarkers Subject to Limits of Detection and Receiver Operating Characteristic Curve Inference
Conclusions: Properly addressing LODs can lead to optimal biomarker combinations with increased discriminatory ability that may have been ignored because of measurement obstacles. (Source: Academic Radiology)
Source: Academic Radiology - June 12, 2013 Category: Radiology Authors: Neil J. Perkins, Enrique F. Schisterman, Albert Vexler Tags: Receiver Operating Characteristic Analysis Source Type: research

The Effect of Low‐ versus High‐Variance in Product Reviews on Product Evaluation
ABSTRACT This research investigates whether the effect of low‐ versus high‐variance product reviews on the evaluation of a product about which consumers have favorable or unfavorable prior expectation can vary depending on product type, the argument quality of product reviews, and the number of reviewers. The data across three laboratory experiments demonstrate that high‐variance product reviews are more likely than low‐variance product reviews to undermine product evaluation when consumers have unfavorable prior expectation about a product. When consumers have favorable prior expectation, however, high‐variance ...
Source: Psychology and Marketing - June 12, 2013 Category: Psychiatry & Psychology Authors: Se‐Bum Park, Do‐Hyung Park Tags: Research Article Source Type: research

Detection of B‐Cell populations with monotypic light chain expression in cerebrospinal fluid specimens from patients with multiple sclerosis by Polychromatic Flow Cytometry
Conclusions: We conclude that the detection of a B‐cell population with monotypic light chain expression in CSF by polychromatic flow cytometry is not diagnostic of occult leptomeningeal involvement by a B‐cell non‐Hodgkin lymphoma. Moreover, these findings suggest that monotypic B‐cell populations detectable by polychromatic flow cytometry may be prevalent in patients with multiple sclerosis, and highlight the importance of clinicopathologic correlation in this application of polychromatic flow cytometry. © 2013 Clinical Cytometry Society (Source: Cytometry Part B: Clinical Cytometry)
Source: Cytometry Part B: Clinical Cytometry - June 12, 2013 Category: Molecular Biology Authors: Poopak Vafaii, Joseph A. DiGiuseppe Tags: Original Article Source Type: research

Nighttime Blood Pressure and New-Onset Left Ventricular Hypertrophy: Findings From the Pamela Population [Heart]
The relationship between circadian blood pressure (BP) variations and the extent of subclinical cardiac organ damage is still debated. In a general population, we investigated the association of night-to-day BP fall, as well as nocturnal BP level (mean and lowest values), with left ventricular (LV) hypertrophy and the value of both BP parameters in predicting new-onset LV hypertrophy. Office BP, 24-hour ambulatory BP values, and laboratory investigations were assessed on entry in 1682 subjects (50.2% men; mean age, 50.2±13.7 years) of the Pressioni Arteriose Monitorate E Loro Associazioni. Echocardiographic LV mass ...
Source: Hypertension - June 12, 2013 Category: Cardiology Authors: Cuspidi, C., Facchetti, R., Bombelli, M., Sala, C., Negri, F., Grassi, G., Mancia, G. Tags: Hypertrophy Heart Source Type: research

Short‐Term Effects of Atorvastatin in Normal Dogs and Dogs with Congestive Heart Failure Due to Myxomatous Mitral Valve Disease
Conclusions and Clinical ImportanceAtorvastatin was well tolerated at clinically relevant doses in healthy dogs and dogs with CHF. Further investigation into the effects of statin treatment in dogs with CHF is warranted. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - June 12, 2013 Category: Veterinary Research Authors: S.M. Cunningham, J.E. Rush, L.M. Freeman Tags: Brief Communication Source Type: research

[Testosterone deficiency - an underestimated risk for men? : Prevalence of hypogonadism.]
CONCLUSIONS: The data reveal high rates of testosterone deficiency in men independent of patient age. As decreased serum testosterone levels may be the consequence of several diseases and can be causally involved in the pathogenesis of further diseases, it is strongly recommended that serum testosterone measurement should be included in the diagnostic arsenal especially when symptoms, such as loss of libido, erectile dysfunction, lack of concentration, depression, lethargy, irritability and sleep disturbance are present. PMID: 23754609 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)
Source: Der Urologe. Ausg. A - June 12, 2013 Category: Urology & Nephrology Authors: Jäger T, Kramer J, Bätz O, Rübben H, von Ostau C, Szarvas T Tags: Urologe A Source Type: research

Surface change of root canal dentin after the use of irrigation activation protocols: Electron microscopy and an energy‐dispersive X‐ray microanalysis
This study evaluated the mineral contents of root‐canal dentin after treatment with different irrigation activation protocols. One hundred and eight maxillary lateral incisor teeth were randomly divided into eight experimental groups and one control group. Root canals were prepared using ProTaper rotary files, with the exception of the Self‐Adjusting File (SAF) group. Canals were irrigated with 2 mL of 5% sodium hypochlorite (NaOCl) at each instrument change, and received a final flush with 10 mL of 17% ethylenediaminetetraacetic acid (EDTA) and 10 mL of 5% NaOCl for 1 min. The control group was irrigated with distille...
Source: Microscopy Research and Technique - June 12, 2013 Category: Laboratory Medicine Authors: Ismail Davut Capar, Hale Ari Aydinbelge Tags: Research Article Source Type: research

The gray institute ‘open’ high‐content, fluorescence lifetime microscopes
We describe a microscopy design methodology and details of microscopes built to this ‘open’ design approach. These demonstrate the first implementation of time‐domain fluorescence microscopy in a flexible automated platform with the ability to ease the transition of this and other advanced microscopy techniques from development to use in routine biology applications. This approach allows easy expansion and modification of the platform capabilities, as it moves away from the use of a commercial, monolithic, microscope body to small, commercial off‐the‐shelf and custom made modular components. Drawings and diagrams...
Source: Journal of Microscopy - June 12, 2013 Category: Laboratory Medicine Authors: P. R. BARBER, I. D. C. TULLIS, G. P. PIERCE, R. G. NEWMAN, J. PRENTICE, M. I. ROWLEY, D. R. MATTHEWS, S. M. AMEER‐BEG, B. VOJNOVIC Tags: Original Article Source Type: research

Prevalence and genetic characterization ofCryptosporidiumspp. andCystoisospora belliin HIV-infected patients.
The objective of this study was to evaluate the frequency of these intestinal protozoa in HIV-positive patients in the Triângulo Mineiro region of Brazil and to correlate the presence of these infections with clinical, epidemiological and laboratory data of the patients. Oocysts were detected in stool samples of 10 (16.9%) of the 59 patients studied, while Cryptosporidium spp. were present in 10.1% (6/59) and C. belli in 6.7% (4/59). The frequency of these parasites was higher among patients with diarrheic syndrome and CD4+ T lymphocyte counts < 200 cells/mm 3 , demonstrating the opportunistic characteristic of these i...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - June 11, 2013 Category: Tropical Medicine Authors: Assis DC, Resende DV, Cabrine-Santos M, Correia D, Oliveira-Silva MB Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Intestinal parasites in a quilombola community of the Northern State of Espírito Santo, Brazil.
Abstract The aim of this study was to determine the occurrence of intestinal parasites in a quilombola community from the northern Espírito Santo, Brazil. Descendants of slaves who arrived in Brazil in the sixteenth century, this population settled in the municipality of São Mateus in 1858. Fresh fecal samples from 82 individuals who agreed to participate in the study were collected between August 2009 and July 2010, and immediately sent to the Clinical Laboratory of the Centro Universitário Norte do Espírito Santo of the Universidade Federal do Espírito Santo for analysis. Out of all the participants, 36 (43....
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - June 11, 2013 Category: Tropical Medicine Authors: Damazio SM, Lima Mde S, Soares AR, Souza MA Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Warthin's tumor associated with IgG4-related disease
Abstract: Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. Several inflammatory conditions associated with IgG4-RD have been reported. Warthin's tumor is a benign parotid gland tumor consisting of oncocytic epithelial cells and lymphoid stroma containing lymphoid follicles with reactive germinal centers. This is the first report describing a case of Warthin's tumor with possible involvement of IgG4-RD. The patient was a 71-year-old man presenting with swollen right parotid and bilateral submandibular ...
Source: Auris, Nasus, Larynx - June 11, 2013 Category: ENT & OMF Authors: Mitsuharu Aga, Satoru Kondo, Kazunori Yamada, Seiko Sawada-Kitamura, Sayaka Yagi-Nakanishi, Kazuhira Endo, Naohiro Wakisaka, Shigeyuki Murono, Mitsuhiro Kawano, Tomokazu Yoshizaki Tags: Case Reports Source Type: research

Utilization of Technology by Long-Term Care Providers: Comparisons Between For-Profit and Nonprofit Institutions
Discussion: The reasons for which nonprofit long-term care organizations report higher levels of some types of technology utilization are explored, and future research is recommended. (Source: Journal of Aging and Health)
Source: Journal of Aging and Health - June 11, 2013 Category: Geriatrics Authors: Hamann, D. J., Bezboruah, K. C. Tags: Articles Source Type: research

Tuberculous meningitis: presentation, diagnosis and outcome in hiv-infected patients at the douala general hospital, cameroon: a cross sectional study
Conclusion: TBM is a common complication in HIV-infected patients in Douala with high case fatality. Its presumptive diagnosis reposes mostly on CSF analysis, so clinicians caring for HIV patients should not hesitate to do lumbar taps in the presence of symptoms of central nervous system disease. (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - June 11, 2013 Category: Infectious Diseases Authors: Henry LumaBenjamin TchaleuBertrand NgahanneElvis TemfackMarie DouallaMarie HalleHenry JokoSinata Koulla-Shiro Source Type: research

Genetic testing in children with surfactant dysfunction
Conclusions Surfactant mutation analysis is now well established in the UK and allows better genetic diagnosis and counselling. The rarity of the condition makes it difficult to develop a validated algorithm for genetic evaluation with a need for international networking. Referrals need to be rationalised for the service to be time and cost effective. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - June 11, 2013 Category: Pediatrics Authors: Turcu, S., Ashton, E., Jenkins, L., Gupta, A., Mok, Q. Tags: Molecular genetics, Pregnancy, Reproductive medicine Original article Source Type: research

Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT)
DiscussionThe baseline distribution of newer biomarkers does not appear to track to markers of kidney function and therefore may offer some discriminatory value in predicting future outcomes. The granularity of the data presented at baseline may foster additional questions.The value of the cohort as a unique resource to understand outcomes of patients under the care of nephrologists in a single payer healthcare system cannot be overstated. Systematic collection of demographic, laboratory and event data should lead to new insights.The mean age of the cohort was 68 years, 90% were Caucasian, 62% were male, and 48% had diabet...
Source: BMC Nephrology - June 11, 2013 Category: Urology & Nephrology Authors: Adeera LevinClaudio RigattoBarrett BrendanFrançois MadoreNorman MuirheadDaniel HolmesCatherine ClaseMila TangOgnjenka Djurdjev Source Type: research

Translational models of ocular disease
Abstract Animals provide indispensable models to translate basic mechanistic discoveries and realize their therapeutic potential in humans. Conversely, advances in human medicine often inform management of similar conditions in clinical veterinary medicine. In this paper, key experimental model species are introduced, with emphasis on genetic contributions of the mouse. Its role and those of larger animal models are described in common ocular research areas including intraocular neoplasia, corneal epithelial and stromal disease, cataract, uveitis, glaucoma, and retinal dystrophies. Emphasis is placed on those conditions sh...
Source: Veterinary Ophthalmology - June 11, 2013 Category: Veterinary Research Authors: Caroline J. Zeiss Tags: Review Source Type: research

Performance of KCl:Eu(2+) storage phosphor dosimeters for low-dose measurements.
Abstract Recent research has demonstrated that europium doped potassium chloride (KCl:Eu(2+)) storage phosphor material has the potential to become the physical foundation of a novel and reusable dosimetry system using either film-like devices or devices similar to thermoluminescent dosimeter chips. The purposes of this work are to quantify the performance of KCl:Eu(2+) prototype dosimeters for low-dose measurements and to demonstrate how it can be incorporated into clinical application for in vivo peripheral dose measurements. Pellet-style KCl:Eu(2+) dosimeters, 6 mm in diameter, and 1 mm thick, were fabricate...
Source: Physics in Medicine and Biology - June 10, 2013 Category: Physics Authors: Li HH, Xiao Z, Hansel R, Knutson N, Yang D Tags: Phys Med Biol Source Type: research

Chemical Composition of Sodium Percarbonate: An Inquiry-Based Laboratory Exercise
Journal of Chemical EducationDOI: 10.1021/ed400077q (Source: Journal of Chemical Education)
Source: Journal of Chemical Education - June 10, 2013 Category: Chemistry Authors: Takeshi Wada and Nobuyoshi Koga Source Type: research

Influence of crystal structure on debonding failure of zirconia veneered restorations
Abstract: Objective: Delamination of porcelain from intact zirconia framework was recently reported as the most common failure mode of these restorations. The aim of this study was to investigate the influence of different laboratory surface treatments on crystals structure and fracture strength of zirconia veneered restorations.Methods: Zirconia discs received airborne particle abrasion with either 50 or 120μm alumina particles then half of the specimens were annealed to remove surface pre-stresses, while assintered discs served as a control. Crystal structure of each group was evaluated using X-ray diffraction analysis ...
Source: Dental Materials - June 10, 2013 Category: Materials Science Authors: Moustafa N. Aboushelib, Hang Wang Tags: Online only articles Source Type: research

Self-adhesive restoratives as pit and fissure sealants: A comparative laboratory study
Abstract: Objectives: To evaluate the properties of self-adhesive restorative materials used as sealants in comparison with sealants with hydrophobic or hydrophilic monomers.Methods: The self-adhesive materials tested were Fusio (FS) and Vertise-Flow (VF) and the sealants Embrace Wetbond (EM/hydrophilic) and Helioseal-F (HS/hydrophobic). The properties tested were: (a) degree of cure (%DC, n: 5, ATR-FTIR), (b) extent of oxygen inhibition (n: 5, transmission optical microscopy), (c) flow (n: 5, ASTM D-4242 method), (d) hardness (VH0.2kp/10s dry/1w in water), (e) adaptation, microleakage and fissure penetration (n: 10, 1% fu...
Source: Dental Materials - June 10, 2013 Category: Materials Science Authors: Anna Eliades, Eleftheria Birpou, Theodore Eliades, George Eliades Tags: Original articles Source Type: research

Mean platelet volume is associated with the presence of left atrial stasis in patients with non-valvular atrial fibrillation
Conclusions: These findings suggest that mean platelet volume may be associated with the presence of markers of left atrial stasis, reinforcing a likely cardioembolic mechanism for its association with stroke in patients with non-valvular atrial fibrillation. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - June 10, 2013 Category: Cardiology Authors: Rui ProvidênciaAna FaustinoLuís PaivaAndreia FernandesSérgio BarraJoana PimentaJoana TrigoAna BotelhoAntónio Leitão-Marques Source Type: research

Toddler inhibited temperament, maternal cortisol reactivity and embarrassment, and intrusive parenting.
The relevance of parenting behavior to toddlers’ development necessitates a better understanding of the influences on parents during parent–child interactions. Toddlers’ inhibited temperament may relate to parenting behaviors, such as intrusiveness, that predict outcomes later in childhood. The conditions under which inhibited temperament relates to intrusiveness, however, remain understudied. A multimethod approach would acknowledge that several levels of processes determine mothers’ experiences during situations in which they witness their toddlers interacting with novelty. As such, the current study examined mat...
Source: Journal of Family Psychology - June 10, 2013 Category: Psychiatry & Psychology Authors: Kiel, Elizabeth J.; Buss, Kristin A. Source Type: research

Long‐Term Safety and Efficacy of Rilonacept in Patients with Systemic Juvenile Idiopathic Arthritis (sJIA)
Conclusions: Sustained improvements in clinical and laboratory assessments of articular and systemic manifestations of sJIA were achieved in >50% of rilonacept‐treated patients over 2 years. Treatment with rilonacept had a substantial steroid‐sparing effect and was generally well‐tolerated © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - June 10, 2013 Category: Rheumatology Authors: Daniel J. Lovell, Edward H. Giannini, Andreas O. Reiff, Yukiko Kimura, Suzanne Li, Philip J. Hashkes, Carol A. Wallace, Karen B. Onel, Dirk Foell, Richard Wu, Stephanie Biedermann, Jennifer D. Hamilton, Allen R. Radin Tags: Full Length Source Type: research

Biomechanical analysis of the anterior cruciate ligament deficiency in the transverse plane. a laboratory in vivo controlled study
Conclusions Torque curve analysis identified a distinctive pattern comparing ACLd and control groups. The crossover showed a dual behaviour with an initial avoidance pattern followed by reinforcement in the last third of the turn. The pivoting-vertical-jump showed an avoidance pattern significant in a small portion of the middle stance. Despite the tendency towards an increase in the tibial internal rotation, a dynamic rotational instability was not detected. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 10, 2013 Category: Sports Medicine Authors: Ferrer, A., Chukwumerije, K., Twycross-Lewis, R., Woledge, R., Morrissey, D., Maffulli, N. Tags: ORAL PRESENTATIONS: NUTRITION, OTHER TOPICS & amp; LIGAMENTS Source Type: research

Acute effects of muscle massage previous to strength training on biochemical markers of delayed onset muscle soreness
Conclusions The presents results suggest that delayed onset muscle soreness induced by two classical strength training exercises, is not prevented or attenuated by muscle massage before exercise. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 10, 2013 Category: Sports Medicine Authors: Garrido, N., Oliveira, G., Mendes, R., Sousa, N., Sousa, M. Tags: Physiotherapy POSTERS: POSTER EXCERCISE MEDICINE Source Type: research

Dieting and the self-control of eating in everyday environments: An experience sampling study.
CONCLUSIONS: Dietary restraint was unrelated to desire frequency and strength, but associated with higher conflict experiences and motivation to use self-control with regard to food desires. Most importantly, relationships between dietary restraint and resistance, enactment of desire, and long-term weight change were moderated by inhibitory control: Compared with dieters low in response inhibition, dieters high in response inhibition were more likely to attempt to resist food desires, not consume desired food (especially unhealthy food), and objectively lost more weight over the ensuing 4 months. These results highlight t...
Source: British Journal of Health Psychology - June 10, 2013 Category: Psychiatry & Psychology Authors: Hofmann W, Adriaanse M, Vohs KD, Baumeister RF Tags: Br J Health Psychol Source Type: research

M2-polarized tumor-associated macrophages promoted epithelial–mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway
M2-polarized tumor-associated macrophages promoted epithelial–mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway Laboratory Investigation advance online publication, June 10 2013. doi:10.1038/labinvest.2013.69 Authors: Chao-Ying Liu, Juan-Ying Xu, Xiao-Yan Shi, Wei Huang, Ting-Yan Ruan, Ping Xie & Jun-Li Ding (Source: Laboratory Investigation AOP)
Source: Laboratory Investigation AOP - June 10, 2013 Category: Laboratory Medicine Authors: Chao-Ying LiuJuan-Ying XuXiao-Yan ShiWei HuangTing-Yan RuanPing XieJun-Li Ding Tags: epithelial-to-mesenchymal transition IL-10 M2-polarized TAMs pancreatic cancer Toll-like receptor 4 Source Type: research

Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8
& Yoshikazu Kinoshita (Source: Laboratory Investigation AOP)
Source: Laboratory Investigation AOP - June 10, 2013 Category: Laboratory Medicine Authors: Tsuyoshi MishiroRyusaku KusunokiAya OtaniMd Mesbah Uddin AnsaryMiki TonguNanae HarashimaTakaya YamadaShuichi SatoYuji AmanoKazuhito ItohShunji IshiharaYoshikazu Kinoshita Tags: apoptosis butyric acid intestinal inflammation milk fat globule-epidermal growth factor 8 16S rRNA sequence Source Type: research

Paediatric autoimmune encephalopathies: clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigens
Conclusions Our study outlines the common clinical and paraclinical features of children and adolescents with probable autoimmune encephalopathies. These patients, irrespective of positivity for the known antibody targets, appeared to benefit from immunotherapies and further antibody targets may be defined in the future. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 9, 2013 Category: Neurosurgery Authors: Hacohen, Y., Wright, S., Waters, P., Agrawal, S., Carr, L., Cross, H., De Sousa, C., DeVile, C., Fallon, P., Gupta, R., Hedderly, T., Hughes, E., Kerr, T., Lascelles, K., Lin, J.-P., Philip, S., Pohl, K., Prabahkar, P., Smith, M., Williams, R., Clarke, A. Tags: JNNP Patients' choice, Open access, Immunology (including allergy), Drugs: CNS (not psychiatric), Epilepsy and seizures, Infection (neurology), Memory disorders (psychiatry), Adult intensive care Neuro-inflammation Source Type: research