Laboratory Medicine Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 22.

Lymphocytic Follicles and Aggregates Are a Determinant of Mucosal Damage and Duration of Diarrhea.
Conclusions.-Lymphocytic follicles and aggregates colitis, previously regarded as of negligible diagnostic significance, allows the prediction of the behavior of chronic diarrhea in a subset of patients with nonspecific changes on colonic biopsy. The increased number of mast cells and paucity of Treg cells further helps to identify such unresolved cases. PMID: 23276179 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - January 1, 2013 Category: Laboratory Medicine Authors: Shah N, Thakkar B, Shen E, Loh M, Chong PY, Gan WH, Tu TM, Shen L, Soong R, Salto-Tellez M Tags: Arch Pathol Lab Med Source Type: research

Multiple factors contribute to positive results for hepatitis a virus immunoglobulin m antibody.
Conclusions.-Current assays for IgM HAV antibodies are overused in the absence of clinical acute hepatitis; future clinical decision support may improve patterns of order entry. Most patients have findings consistent with HAV exposure but not acute hepatitis; dormant viral infection may be a continuing source of antigen. PMID: 23276180 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - January 1, 2013 Category: Laboratory Medicine Authors: Alatoom A, Ansari MQ, Cuthbert J Tags: Arch Pathol Lab Med Source Type: research

The development of a novel molecular assay examining the role of aminopeptidase p polymorphisms in acute hypotensive transfusion reactions.
Conclusions.-Our C-2399A SNP assay can be used to study acute hypotensive transfusion reactions in patients not taking ACE-Is. Initial data indicate that the C-2399A polymorphism may be a contributing factor in such reactions. However, further studies are necessary to better define the role of APP polymorphisms in relation to acute hypotensive transfusion reactions unassociated with ACE-Is. PMID: 23276181 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - January 1, 2013 Category: Laboratory Medicine Authors: Hui Y, Wu Y, Tormey CA Tags: Arch Pathol Lab Med Source Type: research

Evaluating the connections between primary care practice and clinical laboratory testing: a review of the literature and call for laboratory involvement in the solutions.
Conclusions.-The focused literature review documented 7 key error themes in the laboratory medicine/primary care testing process. Performance metrics related to these themes are proposed that deserve future study for evidence-based improvement. PMID: 23276182 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - January 1, 2013 Category: Laboratory Medicine Authors: Smith ML, Raab SS, Fernald DH, James KA, Lebin JA, Grzybicki DM, Zelie C, West DR Tags: Arch Pathol Lab Med Source Type: research

Papillary syncytial metaplasia of fallopian tube endometriosis: a potential pitfall in the diagnosis of serous tubal intraepithelial carcinoma.
Abstract Histopathologic diagnosis of tubal intraepithelial carcinoma (TIC) has emerged as a significant challenge in the last few years. The avoidance of pitfalls in the diagnosis of TIC is crucial if a better understanding of its natural history and outcome is to be achieved. Herein, we present a case of a 52-year-old woman who underwent a risk-reducing salpingo-oophorectomy procedure. Histologic examination of a fallopian tube demonstrated a focus of atypical epithelial proliferation, which was initially considered to be a TIC. Complete study of the case indicated that the focus was, in fact, papillary syncytial...
Source: Archives of Pathology and Laboratory Medicine - January 1, 2013 Category: Laboratory Medicine Authors: Kaur H, Levinsky E, Colgan TJ Tags: Arch Pathol Lab Med Source Type: research

Burkitt Lymphoma Arising From Lymphoplasmacytic Lymphoma Following Acquisition of MYC Translocation and Loss of the ETV6 Tumor Suppressor Gene.
We report the case of a 70-year-old woman with a 9-year history of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia who presented with rapid enlargement of a left neck mass and pancytopenia, which was diagnosed as Burkitt lymphoma with extensive bone marrow involvement. A series of histopathologic, molecular, and cytogenetic evaluations proved a cytogenetic evolution including t(8;14)(q24;q32)/MYC-IgH and identical clonal B-cell gene rearrangements from the 2 distinct lymphomas, confirming stage 4 aggressive Burkitt lymphoma arising from lymphoplasmacytic lymphoma. PMID: 23276184 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - January 1, 2013 Category: Laboratory Medicine Authors: Peker D, Quigley B, Qin D, Papenhausen P, Zhang L Tags: Arch Pathol Lab Med Source Type: research

Fibrous dysplasia.
Abstract Fibrous dysplasia is an uncommon bone disease. The diagnosis is usually not difficult, given the symptoms, radiology, and histology. The gene involved is the α subunit of the G-protein receptor. Recent innovation in molecular pathology has helped us understand the mechanism of disease pathogenesis. The treatment of fibrous dysplasia is limited to maintenance of maximum bone density. Surgical reinforcement is used to treat bowing deformities and fractures as they occur. Malignant transformation of fibrous dysplasia is rare. Currently, there is no therapy for preventing the disease from advancing or for mal...
Source: Archives of Pathology and Laboratory Medicine - January 1, 2013 Category: Laboratory Medicine Authors: Riddle ND, Bui MM Tags: Arch Pathol Lab Med Source Type: research

Characterization of electroencephalographic and biochemical responses at 5‐HT promoting drug‐induced onset of serotonin syndrome in rats
Abstract Many psychotropic substances used either for medications or illicit recreational purposes are able to produce an increase in extracellular serotonin (5HT) in the CNS. 5HT is well known to improve mood, however, only when the levels of its release are in an appropriate range. Excessive 5HT is harmful, and will generally result in serotonin syndrome. To date, clinical diagnosis of serotonin syndrome relies exclusively on observation of symptoms because of a lack of available laboratory tests. The goal of the present study was to characterize the onset of the syndrome using laboratory settings to determine excessive ...
Source: Journal of Neurochemistry - January 1, 2013 Category: Neurology Authors: Zhiyuan Ma, Mary Rudacille, Howard M. Prentice, Rui Tao Tags: Original Article Source Type: research

Modeling the effects of positive and negative mood on the ability to resist eating in obese and non-obese individuals.
Abstract This pilot study adapted a well-established drug self-administration paradigm to examine the effects of mood induction on the ability to resist high-calorie foods and subsequent food consumption differently in 15 obese individuals (40.0% women, BMI: 35.1±3.70) and 15 non-obese individuals (46.7% women, BMI: 23.0±1.96). Participants completed two laboratory sessions (positive vs. negative mood conditions) consisting of 3-hour food deprivation, followed by mood induction, and a 3-hour ad-lib eating period, where they were asked to choose between favorite high-calorie snacks and monetary reinforcement. Obes...
Source: Eating Behaviors - January 1, 2013 Category: Eating Disorders and Weight Management Authors: Udo T, Grilo CM, Brownell KD, Weinberger AH, Dileone RJ, McKee SA Tags: Eat Behav Source Type: research

Failure to feed patients with anorexia nervosa and other perils and perplexities in the medical care of eating disorder patients.
Abstract A 28 year old woman with anorexia nervosa was sent to an emergency room by her gastroenterologist for weakness and nausea following placement of a percutaneous endoscopic gastrostomy (PEG) tube, with a plan for admission to the hospital. She spent 2 days in the emergency room without receiving any nutrition, and was discharged home after being told that her laboratory tests and x-rays were normal. The following day, her gastroenterologist reviewed the x-rays and determined that she had a bowel obstruction, at which point she was admitted to the hospital, weighing 2 kg less than on her initial visit. A 26 ...
Source: Eating Disorders - January 1, 2013 Category: Eating Disorders and Weight Management Authors: Powers PS, Cloak NL Tags: Eat Disord Source Type: research

Coagulopathy in Patients With Late-Onset Ornithine Transcarbamylase Deficiency in Remission State: A Previously Unrecognized Complication
This study focused on coagulopathy in OTC deficiency. We collected laboratory data regarding coagulation from OTC-deficient patients in Kyushu University Hospital in Japan or from cases reported from previous articles. Five patients with late-onset OTC deficiency, admitted to Kyushu University Hospital at the first metabolic attack or who presented at the outpatient clinic in the hospital, were analyzed, and 3 additional cases of OTC deficiency with coagulopathy in previous articles were included. As a result, the blood ammonia levels in these patients were remarkably high at the time of the metabolic attack, and prothromb...
Source: PEDIATRICS - January 1, 2013 Category: Pediatrics Authors: Ihara, K., Yoshino, M., Hoshina, T., Harada, N., Kojima-Ishii, K., Makimura, M., Hasegawa, Y., Watanabe, Y., Yamaguchi, S., Hara, T. Tags: Case Report Source Type: research

Current Guideline For The Neurodiagnostic Evaluation Of The Child With A Simple Febrile Seizure
In this issue of EM Practice Guidelines Update, the 2011 American Academy of Pediatrics (AAP) update regarding neurodiagnostic evaluation of pediatric simple febrile seizures is reviewed. Simple febrile seizures are largely benign events with good prognoses, and they often do not require laboratory studies or neurodiagnostic imaging to be performed in the emergency department (ED). This update of the 1996 AAP guideline focuses on the use of lumbar puncture in children who present to the ED with a simple febrile seizure.
Source: EM Practice Guidelines Update - December 31, 2012 Category: Emergency Medicine Source Type: research

Sleep to Implement an Intention
Conclusions:Sleep, especially SWS, plays an important role for the successful implementation of delayed intentions.Citation:Diekelmann S; Wilhelm I; Wagner U; Born J. Sleep to implement an intention. SLEEP 2013;36(1):149-153.
Source: Sleep - December 31, 2012 Category: Sleep Medicine Source Type: research

Attenuated Heart Rate Response is Associated with Hypocretin Deficiency in Patients with Narcolepsy
Conclusions:Our results show that autonomic dysfunction is part of the narcoleptic phenotype, and that hypocretin-1 deficiency is the primary predictor of this dysfunction. This finding suggests that the hypocretin system participates in the modulation of cardiovascular function at rest.Citation:Sorensen GL; Knudsen S; Petersen ER; Kempfner J; Gammeltoft S; Sorensen HBD; Jennum P. Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy. SLEEP 2013;36(1):91–98.
Source: Sleep - December 31, 2012 Category: Sleep Medicine Source Type: research

Local Experience-Dependent Changes in the Wake EEG after Prolonged Wakefulness
Conclusions:Extended experience-dependent plasticity of specific circuits results in a local increase of the wake theta EEG power in those regions, followed by more intense sleep, as reflected by SWA, over the same areas.Citation:Hung CS; Sarasso S; Ferrarelli F; Riedner B; Ghilardi MF; Cirelli C; Tononi G. Local experience-dependent changes in the wake EEG after prolonged wakefulness. SLEEP 2013;36(1):59–72.
Source: Sleep - December 31, 2012 Category: Sleep Medicine Source Type: research

Quest Diagnostics sells Brentwood testing lab
Medical testing giant Quest Diagnostics (NYSE: DGX) announced Monday that it had sold its salivary diagnostics business that operates from Brentwood. The Madison, N.J.-based Quest sold its OralDNA Labs to clinical laboratory Access Genetics. The Quest division provides testing services from a facility in Brentwood, which will consolidate under Access’ lab in Eden Prairie, Minn. Terms of the deal were not disclosed.
Source: bizjournals.com Health Care:Hospitals headlines - December 31, 2012 Category: Hospital Management Authors: Lori Becker Source Type: research

Equestrian chilblain: another outdoor recreational hazard
Abstract Herein, we describe two cases and review fourteen cases of equestrian chilblain or “equestrian cold panniculitis” in the literature. The first, a 23‐year‐old healthy female horse trainer, presented with burning nodular swelling on her lateral thighs. The second was a 34‐year‐old healthy woman with recurrent nodular eruption on the lateral thighs after horseback riding in the winter. Physical examination of both patients revealed erythematous to violaceous nodules with eczema craquelé‐like changes. Laboratory workup for systemic and autoimmune connective tissue disease was negative. Punch biopsies fr...
Source: Journal of Cutaneous Pathology - December 31, 2012 Category: Pathology Authors: Amy Y. Yang, Laurel Schwartz, Allison K. Divers, Lauren Sternberg, Jason B. Lee Tags: Case Report Source Type: research

Phenotypic analysis of mutant and overexpressing strains of lipid metabolism genes in Saccharomyces cerevisiae: Implication in growth at low temperatures.
Abstract The growing demand for wines with a more pronounced aromatic profile calls for low temperature alcoholic fermentations (10-15°C). However, there are certain drawbacks to low temperature fermentations such as reduced growth rate, long lag phase and sluggish or stuck fermentations. The lipid metabolism of Saccharomyces cerevisiae plays a central role in low temperature adaptation. The aim of this study was to detect lipid metabolism genes involved in cold adaptation. To do so, we analyzed the growth of knockouts in phospholipids, sterols and sphingolipids, from the EUROSCARF collection S. cerevisiae BY4742 ...
Source: International Journal of Food Microbiology - December 31, 2012 Category: Food Science Authors: López-Malo M, Chiva R, Rozes N, Guillamon JM Tags: Int J Food Microbiol Source Type: research

Renal autotransplantation - a possibility in the treatment of complex renal vascular diseases and ureteric injuries.
Conclusions: The present study reports excellent results of renal autotransplantation in patients with renovascular disease or complex ureteric injuries. After a median follow-up of 9.7 years all 6 patients present with stable renal function as well as normal blood pressure values. Postoperative complications were observed with a rate comparable to other studies. PMID: 23274320 [PubMed - in process]
Source: Annals of Transplantation - December 31, 2012 Category: Transplant Surgery Authors: Hau HM, Bartels M, Tautenhahn HM, Morgul MH, Fellmer P, Ho-Thi P, Benckert C, Uhlmann D, Moche M, Thelen A, Schmelzle M, Jonas S Tags: Ann Transplant Source Type: research

Predictive factors associated with re-exploration for hemostasis in living donor liver transplantation.
Conclusions: Each elevation of 1ml of transfused FFP per kg is associated with a 1.033-fold increased incidence of re-exploration for hemostasis. Patients transfused with more than 10 ml/kg FFP during LT require more intensive management within 72 hours due to increase risk of postoperative bleeding. PMID: 23274326 [PubMed - in process]
Source: Annals of Transplantation - December 31, 2012 Category: Transplant Surgery Authors: Wu SC, Chen CL, Wang CH, Huang CJ, Cheng KW, Shih TH, Yang JC, Jawan B Tags: Ann Transplant Source Type: research

Cost analysis of kidney transplantation in highly sensitized recipients compared to intermittent maintenance hemodialysis.
Conclusions: Despite using costly desensitization protocols, kidney transplantation in sensitized patients provides long-term cost savings compared to maintenance hemodialysis. PMID: 23274328 [PubMed - in process]
Source: Annals of Transplantation - December 31, 2012 Category: Transplant Surgery Authors: Al-Jedai A, Alsultan M, Almeshari K, Alshaibani K, Elgamal H, Alkortas D, Khurshid F, Altalhi M, Hamawi K Tags: Ann Transplant Source Type: research

Marked toxicity of Albizia bernieri extracts on embryo-larval development in the medaka fish (Oryzias latipes).
Abstract Previous phytochemical studies have shown that the plants of the Albizia genus (Fabaceae) contain bioactive saponins, lignans, spermine alkaloids, flavonoids, glycosides phenols and pyridoxine derivatives. Their extracts sometimes display medical properties, but can have also toxic effects. The purpose of our study was to determine the in vivo toxicity of Albizia bernieri seeds in the experimental model of the medaka fish embryo, which is recommended for use in toxicity studies. Our results show clearly that incubating the embryos or larvae of the medaka fish in a medium containing A. bernieri extracts ca...
Source: Toxicon - December 31, 2012 Category: Toxicology Authors: Randriamampianina L, Offroy A, Mambu L, Randrianarivo R, Rakoto D, Jeannoda V, Djediat C, Puiseux Dao S, Edery M Tags: Toxicon Source Type: research

Getting Better With Age: The Relationship Between Age, Acceptance, and Negative Affect.
Abstract Although aging involves cognitive and physical declines, it is also associated with improved emotional well-being, particularly lower negative affect. However, the relationship between age and global negative affect, versus discrete negative emotions, and the pathways that link age to lower negative affect are not well understood. We hypothesize that 1 important link between age and lower negative affect may be acceptance of negative emotional experiences. The present study examined this hypothesis in a community sample of 21- to 73-year-olds (N = 340) by measuring acceptance and multiple indices of negati...
Source: Journal of Personality and Social Psychology - December 31, 2012 Category: Psychiatry & Psychology Authors: Shallcross AJ, Ford BQ, Floerke VA, Mauss IB Tags: J Pers Soc Psychol Source Type: research

Exposure to the Polybrominated Diphenyl Ether Mixture DE-71 Damages the Nigrostriatal Dopamine System: Role of Dopamine Handling in Neurotoxicity.
Abstract In the last several decades polybrominated diphenyl ethers (PBDEs) have replaced the previously banned polychlorinated biphenyls (PCBs) in multiple flame retardant utilities. As epidemiological and laboratory studies have suggested PCBs as a risk factor for Parkinson's disease (PD), the similarities between PBDEs and PCBs suggest that PBDEs have the potential to be neurotoxic to the dopamine system. The purpose of this study was to evaluate the neurotoxic effects of the PBDE mixture, DE-71, on the nigrostriatal dopamine system and address the role of altered dopamine handling in mediating this neurotoxicit...
Source: Experimental Neurology - December 31, 2012 Category: Neurology Authors: Bradner JM, Suragh TA, Wilson WW, Lazo CR, Stout KA, Kim HM, Wang MZ, Walker DI, Pennell KD, Richardson JR, Miller GW, Caudle WM Tags: Exp Neurol Source Type: research

Prevalence and characters of Entamoeba histolytica infection in Saudi infants and children admitted with diarrhea at 2 main hospitals at south Jeddah: A re-emerging serious infection with unusual presentation.
In this study, Entamoeba histolytica had high prevalence and unusual presentation by affecting high proportion of infants under 1 year; severe clinical manifestations, and laboratory findings that were known to be usually encountered in invasive amebiasis as significant leukocytosis for age, neutrophilic leukocytosis for age, and positive C-reactive protein were found among more than 50% of admitted Saudi infants and children with E. histolytica infection in our locality. E. histolytica can be a re-emerging serious infection when it finds favorable environmental conditions and host factors which are mainly attributed to in...
Source: Braz J Infect Dis - December 31, 2012 Category: Infectious Diseases Authors: Hegazi MA, Patel TA, El-Deek BS Tags: Braz J Infect Dis Source Type: research

New targets for the antitumor activity of gambogic acid in hematologic malignancies.
Abstract Gambogic acid (GA) is the main active ingredient of gamboge, a brownish to orange dry resin secreted from Garcinia hanburyi, a plant that is widely distributed in nature. Recent in vitro and in vivo studies have demonstrated that GA exerts potent antitumor effects against solid tumors of various derivations, and its antitumor mechanisms have been thoroughly investigated. On the other hand, normal cells remain relatively resistant to GA, indicating a therapeutic window. GA is currently in clinical trials in China. Over the last decade, our laboratory demonstrates that GA exhibits potent anticancer activitie...
Source: Acta Pharmacologica Sinica - December 31, 2012 Category: Drugs & Pharmacology Authors: Yang LJ, Chen Y Tags: Acta Pharmacol Sin Source Type: research

Verifying the Role of Surgical Pathologists in the Precision Medicine of Lung Cancer.
PMID: 23276149 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - December 31, 2012 Category: Laboratory Medicine Authors: Cagle PT, Olsen RJ Tags: Arch Pathol Lab Med Source Type: research

Hemophagocytic syndrome in a cat with multiple myeloma
Abstract An 11‐year‐old, castrated male, Domestic Medium Hair cat was presented to the University of Florida Small Animal Hospital with a 2‐week history of upper respiratory infection and increased serum globulins, as reported by the referring veterinarian. Physical examination was unremarkable other than melanosis of the left iris, with no evidence of ocular, nasal, or respiratory disease. Laboratory abnormalities included moderate nonregenerative anemia, mild leukopenia, mild hyperfibrinogenemia, severe hyperglobulinemia, mild hypoalbuminemia, and hypocholesterolemia. Abdominal radiographs and ultrasonographic exam...
Source: Veterinary Clinical Pathology - December 31, 2012 Category: Veterinary Research Authors: Mark D. Dunbar, Sarah Lyles Tags: Case Report Source Type: research

Direct FGF-2 Gene Transfer via Recombinant Adeno-Associated Virus Vectors Stimulates Cell Proliferation, Collagen Production, and the Repair of Experimental Lesions in the Human ACL
Conclusion: Efficient, stable FGF-2 expression via rAAV enhances the healing of experimental human ACL lesions by activating key cellular and metabolic processes. Clinical Relevance: This approach has potential value for the development of novel, effective treatments for ligament reconstruction.
Source: The American Journal of Sports Medicine - December 31, 2012 Category: Sports Medicine Authors: Madry, H., Kohn, D., Cucchiarini, M. Tags: Injury, Histology Biology and Translational Research Source Type: research

The Systemic Effects of Platelet-Rich Plasma Injection
Conclusion: Serum IGF-1, VEGF, and bFGF levels are significantly elevated after PRP injection, supporting a possible ergogenic effect of PRP. An indirect marker for hGH doping, the product of IGFBP-3 x IGF-1, also significantly increased after PRP. Platelet-rich plasma appears to trigger an increase in circulating growth factors through activating biological pathways rather than by serving as a vehicle for the direct delivery of presynthesized growth factors. Elevated VEGF was observed in all patients after PRP, and ≥88% of patients had elevated VEGF at each time point from 3 to 96 hours after PRP, suggesting that VEGF ...
Source: The American Journal of Sports Medicine - December 31, 2012 Category: Sports Medicine Authors: Wasterlain, A. S., Braun, H. J., Harris, A. H. S., Kim, H.-J., Dragoo, J. L. Tags: Muscle, Histology Biology and Translational Research Source Type: research

Biomechanical Analysis of Surface-Athlete Impacts on Third-Generation Artificial Turf
Conclusion: The results indicate that both an increase in assumed impact-absorbing surface properties and a larger distribution of shorter cleats produced lower impacts during standardized athletic movements. Regardless, none of the shoe-surface combinations yielded peak impacts of an assumed hazardous magnitude. Clinical Relevance: The study provides information on the extent to which various third-generation artificial turf systems and cleat configurations affect impact force, widely believed to be a causative factor for overload and overuse injuries.
Source: The American Journal of Sports Medicine - December 31, 2012 Category: Sports Medicine Authors: McGhie, D., Ettema, G. Tags: Overuse, Soccer, Biomechanics Epidemiology and Injury Prevention Source Type: research

Biomechanical Analysis of a Double-Loaded Glenoid Anchor Configuration: Can Fewer Anchors Provide Equivalent Fixation?
Conclusion: A Bankart repair construct that used 2 double-loaded anchors was either superior to or equal to a repair construct that used 3 single-loaded anchors in all measured outcomes. Clinical Relevance: Using 2 double-loaded suture anchors for a Bankart repair may limit anchor holes in the glenoid and reduce the risk of postsurgical glenoid fracture while providing a stable repair construct.
Source: The American Journal of Sports Medicine - December 31, 2012 Category: Sports Medicine Authors: Kamath, G. V., Hoover, S., Creighton, R. A., Weinhold, P., Barrow, A., Spang, J. T. Tags: Shoulder, Operative, Biomechanics Source Type: research

Three-Dimensional Evaluation of Cyclic Displacement in Single-Row and Double-Row Rotator Cuff Reconstructions Under Static External Rotation
Conclusion: The tested single-row reconstruction achieved superior results in 3D cyclic displacement to the tested double-row repair. Extension of the initial rupture size did not have a negative effect on the biomechanical results of the tested constructs. Clinical Relevance: Single-row repairs with modified suture configurations provide comparable biomechanical strength to double-row repairs. Furthermore, as increased gap formation in the early postoperative period might lead to failure of the construct, a strong anterior fixation and restricted external rotation protocol might be considered in rotator cuff repairs to avoid this problem.
Source: The American Journal of Sports Medicine - December 31, 2012 Category: Sports Medicine Authors: Lorbach, O., Kieb, M., Raber, F., Busch, L. C., Kohn, D. M., Pape, D. Tags: Shoulder, Operative, Biomechanics Source Type: research

The Effect of Medial Opening Wedge Proximal Tibial Osteotomy on Patellofemoral Contact
Conclusion: There was a significant increase in patellofemoral pressures at varying degrees of knee flexion after medial opening wedge proximal tibial osteotomies of only 10 mm; a larger osteotomy resulted in a greater increase. Clinical Relevance: When performing a medial opening wedge proximal tibial osteotomy, the surgeon should consider the negative effects of increased patellofemoral peak pressure.
Source: The American Journal of Sports Medicine - December 31, 2012 Category: Sports Medicine Authors: Javidan, P., Adamson, G. J., Miller, J. R., Durand, P., Dawson, P. A., Pink, M. M., Lee, T. Q. Tags: Knee, Biomechanics Source Type: research

The Effect of Arthroscopic Partial Medial Meniscectomy on Tibiofemoral Stability
Conclusion: Partial medial meniscectomy with ≥46% resection of the original width of the posterior horn significantly altered the AP position of the medial femoral condyle and also increased laxity. Clinical Relevance: These mechanical changes may lead to abnormal cartilage loading and early osteoarthritis.
Source: The American Journal of Sports Medicine - December 31, 2012 Category: Sports Medicine Authors: Arno, S., Hadley, S., Campbell, K. A., Bell, C. P., Hall, M., Beltran, L. S., Recht, M. P., Sherman, O. H., Walker, P. S. Tags: Meniscus, Arthroscopy Knee Source Type: research

Anatomic Femoral Tunnels in Posterior Cruciate Ligament Reconstruction: Inside-Out Versus Outside-In Drilling
Conclusion: This study demonstrates no difference in the ability of the OI and IO techniques to place the femoral tunnel within the PCL femoral footprint during PCL reconstruction. With the technique parameters used in this study, the IO technique created femoral tunnels with a more vertical and anterior orientation than the OI technique. Clinical Relevance: Either technique can be used to place the femoral tunnel within the anatomic footprint. Consideration should be given to tunnel orientation following each technique, and what effect it has on graft bending angles, as these characteristics may affect graft strain and, ...
Source: The American Journal of Sports Medicine - December 31, 2012 Category: Sports Medicine Authors: Tompkins, M., Keller, T. C., Milewski, M. D., Gaskin, C. M., Brockmeier, S. F., Hart, J. M., Miller, M. D. Tags: Knee, Nonoperative, Graft fixation Source Type: research

Radiographic Landmarks for Tunnel Positioning in Posterior Cruciate Ligament Reconstructions
Conclusion: Radiographic measurements from several clinically relevant views of the femur and tibia were reproducible with regard to the anatomic locations of the ALB and PMB centers. The measurements from the lateral femur and tibia views provided the most clinically pertinent radiographic measurements intraoperatively. Clinical Relevance: This study established a set of clinically relevant radiographic guidelines for anatomic reconstruction of the PCL. The parameters set forth in this study can be used in both the intraoperative and postoperative settings for both single- and double-bundle PCL reconstructions.
Source: The American Journal of Sports Medicine - December 31, 2012 Category: Sports Medicine Authors: Johannsen, A. M., Anderson, C. J., Wijdicks, C. A., Engebretsen, L., LaPrade, R. F. Tags: Imaging Studies, Knee, Meniscus, Operative Source Type: research

Papulonecrotic tuberculid with positive acid-fast bacilli
Ren Jun, Liu Xiao-kun, Pan Chao, Li Xin-sheng, Wang Xiao-hui, Yan Xin, Chen Mei-hua, Zeng KangIndian Journal of Dermatology 2013 58(1):85-85Two patients suffered from 'boils' on their arms and/or thighs for several months. A diagnosis of papulonecrotic tuberculid (PNT) was made based on clinical, laboratory parameters, histopathology, and a prompt response to multi-drug anti-tuberculosis treatment. We checked the pathological sections carefully and finally found a small amount of positive acid-fast bacilli. We analyzed the clinical and histopathological features of PNT in order to offer reference of preventin...
Source: Indian Journal of Dermatology - December 31, 2012 Category: Dermatology Authors: Ren JunLiu Xiao-kunPan ChaoLi Xin-shengWang Xiao-huiYan XinChen Mei-huaZeng Kang Source Type: research

Ensuring the reliability of stable isotope ratio data-beyond the principle of identical treatment.
This article considers what lessons can be learned from a series of inter-laboratory comparison exercises organised by the Forensic Isotope Ratio Mass Spectrometry (FIRMS) network in terms of reference materials (RMs), the management of data quality, and technical limitations. The results showed that within-laboratory precision (repeatability) was generally good but between-laboratory accuracy (reproducibility) called for improvements. This review considers how stable isotope laboratories can establish a system of quality control (QC) and quality assurance (QA), emphasising issues of repeatability and reproducibility. For ...
Source: Analytical and Bioanalytical Chemistry - December 30, 2012 Category: Chemistry Authors: Carter JF, Fry B Tags: Anal Bioanal Chem Source Type: research

A New Leg Voxel Model in Two Different Positions for Simulation of the Non-uniform Distribution of 241Am in Leg Bones.
Abstract ABSTRACT: A new leg voxel model in two different positions (straight and bent) has been developed for in vivo measurement calibration purposes. This voxel phantom is a representation of a human leg that may provide a substantial enhancement to Monte Carlo modeling because it more accurately models different geometric leg positions and the non-uniform distribution of Am throughout the leg bones instead of assuming a one-position geometry and a uniform distribution of radionuclides. This was accomplished by performing a radiochemical analysis on small sections of the leg bones from the U.S. Transuranium and ...
Source: Health Physics - December 29, 2012 Category: Physics Authors: Khalaf M, Brey RR, Meldrum J Tags: Health Phys Source Type: research

X-ray phase-contrast imaging: from pre-clinical applications towards clinics.
Abstract Phase-contrast x-ray imaging (PCI) is an innovative method that is sensitive to the refraction of the x-rays in matter. PCI is particularly adapted to visualize weakly absorbing details like those often encountered in biology and medicine. In past years, PCI has become one of the most used imaging methods in laboratory and preclinical studies: its unique characteristics allow high contrast 3D visualization of thick and complex samples even at high spatial resolution. Applications have covered a wide range of pathologies and organs, and are more and more often performed in vivo. Several techniques are now a...
Source: Physics in Medicine and Biology - December 29, 2012 Category: Physics Authors: Bravin A, Coan P, Suortti P Tags: Phys Med Biol Source Type: research

Monte Carlo-based evaluation of S-values in mouse models for positron-emitting radionuclides.
Abstract In addition to being a powerful clinical tool, Positron emission tomography (PET) is also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. However, dosimetric characteristics in small animal PET imaging are usually overlooked, though the radiation dose may not be negligible. In this work, we constructed 17 mouse models of different body mass and size based on the realistic four-dimensional MOBY mouse model. Particle (photons, electrons and po...
Source: Physics in Medicine and Biology - December 29, 2012 Category: Physics Authors: Xie T, Zaidi H Tags: Phys Med Biol Source Type: research

The influence of high intensity terahertz radiation on mammalian cell adhesion, proliferation and differentiation.
This study evaluated the influence of the high peak power, low average power THz radiation produced by the ALICE (Daresbury Laboratory, UK) synchrotron source on human epithelial and embryonic stem cells. The cells were maintained under standard tissue culture conditions, during which the THz radiation was delivered directly into the incubator for various exposure times. The influence of the THz radiation on cell morphology, attachment, proliferation and differentiation was evaluated. The study demonstrated that there was no difference in any of these parameters between irradiated and control cell cultures. It is suggested...
Source: Physics in Medicine and Biology - December 29, 2012 Category: Physics Authors: Williams R, Schofield A, Holder G, Downes J, Edgar D, Harrison P, Siggel-King M, Surman M, Dunning D, Hill S, Holder D, Jackson F, Jones J, McKenzie J, Saveliev Y, Thomsen N, Williams P, Weightman P Tags: Phys Med Biol Source Type: research

Screening for negative effects of candidate ascidian antifoulant compounds on a target aquaculture species, Perna canaliculus Gmelin.
In this study, these compounds were screened for their effects on the physiological health of an aquaculture species, the green-lipped mussel, Perna canaliculus Gmelin, at or above the 99% effective dose (IC(99)) in ascidians. Three physiological biomarkers of mussel health were screened: growth (increases in shell height and wet weight), condition (condition index) and mitochondrial respirational function (Complex I-mediated respiration, Complex II-mediated respiration, maximum uncoupled respiration, leak respiration, respiratory control ratios and phosphorylation system control ratios). While polygodial and Q10 had no ef...
Source: Biofouling - December 29, 2012 Category: Molecular Biology Authors: Cahill PL, Heasman K, Hickey A, Mountfort D, Jeffs A, Kuhajek J Tags: Biofouling Source Type: research

Bacterial cooperation in the wild and in the clinic: Are pathogen social behaviours relevant outside the laboratory?
Abstract Individual bacterial cells can communicate via quorum sensing, cooperate to harvest nutrients from their environment, form multicellular biofilms, compete over resources and even kill one another. When the environment that bacteria inhabit is an animal host, these social behaviours mediate virulence. Over the last decade, much attention has focussed on the ecology, evolution and pathology of bacterial cooperation, and the possibility that it could be exploited or destabilised to treat infections. But how far can we really extrapolate from theoretical predictions and laboratory experiments to make inferences about ...
Source: BioEssays - December 29, 2012 Category: Molecular Biology Authors: Freya Harrison Tags: Prospects & Overviews Source Type: research

Identification of one novel and nine recurrent mutations of the ATP7B gene in 11 children with Wilson disease.
CONCLUSIONS: The novel c.3605 C>G mutation in ATP7B is one of the molecular mechanisms of WND. PMID: 23275100 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - December 29, 2012 Category: Pediatrics Authors: Geng J, Wang J, Yao RE, Liu XQ, Fu QH Tags: World J Pediatr Source Type: research

Influence of cognitive functions and behavioral context on grasping kinematics.
Abstract We have documented before that human grasping movements executed in an everyday-like context differ from those in a typical laboratory context. The differences were reduced by factor analysis to five orthogonal factors; we took this as evidence that at least five distinct sensorimotor functions are context-dependent. To better understand how context exerts its influence on the sensorimotor system, we now evaluate the relationship between context-dependence and cognitive abilities. Forty subjects participated in a laboratory task (L) where grasping was explicitly instructed, externally triggered, repetitive...
Source: Experimental Brain Research - December 29, 2012 Category: Neuroscience Authors: Steinberg F, Bock O Tags: Exp Brain Res Source Type: research

Characteristics of multidrug-resistant tuberculosis in Namibia
Conclusions: MDR-TB was associated with previous treatment for TB, previous hospitalization, and having had a household member with MDR-TB, suggesting that TB control practices have been inadequate. Strengthening basic TB control practices, including expanding laboratory confirmation, directly observed therapy, and infection control, are critical to the prevention of MDR-TB.
Source: BMC Infectious Diseases - December 29, 2012 Category: Infectious Diseases Authors: Philip RicksFarai MavhungaSurbhi ModiRosalia IndongoAbbas ZezaiLauren LambertNick DeLucaJamie KrashinAllyn NakashimaTimothy Holtz Source Type: research

On the use of capillary electrophoresis for the determination of inorganic anions and cations, and carbohydrates in residues collected after a simulated suicide bombing attack.
This article focuses on the combined use, for the first time, of three new capillary electrophoresis methods for the determination of inorganic anions and cations, and carbohydrates in two representative extracts. Capillary electrophoresis appears as an effective tool to identify and quantify the compounds in real extracts and is fully complementary to chromatographic methods. PMID: 23200391 [PubMed - in process]
Source: Talanta - December 28, 2012 Category: Chemistry Authors: Sarazin C, Delaunay N, Costanza C, Eudes V, Gareil P Tags: Talanta Source Type: research

Serum Phosphate and Long-Term Outcome Among Patients With Stable Heart Failure
Abstract: Background: Elevated serum phosphate levels are associated with excess risk for cardiovascular mortality in patients with and without chronic kidney disease and with increased risk for incident heart failure. We determined the association of serum phosphate concentrations with disease severity and long-term outcome in patients with overt heart failure.Methods and Results: Clinical and laboratory parameters of 974 ambulatory heart failure patients were evaluated. Prevalence of elevated phosphate levels (>4.5 mg/dL) was 5.8% in men and 6.0% in women. Phosphate was significantly correlated with disease severity as a...
Source: Journal of Cardiac Failure - December 28, 2012 Category: Cardiology Authors: Michael Ess, Katja Heitmair-Wietzorrek, Matthias Frick, Nikolaus Umlauf, Hanno Ulmer, Gerhard Poelzl Tags: Clinical Investigations Source Type: research