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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 25.

Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation.
Abstract Cosmetics Europe, The Personal Care Association (known as Colipa before 2012), conducted a program of technology transfer and within/between laboratory reproducibility of MatTek Corporation's EpiOcular™ Eye Irritation Test (EIT) as one of the two human reconstructed tissue test methods. This EIT EpiOcular™ used a single exposure period for each chemical and a prediction model based on a cut-off in relative survival [⩽60%=irritant (I) (GHS categories 2 and 1); >60%=no classification (NC)]. Test substance single exposure time was 30min with a 2-h post-exposure incubation for liquids and 90min with a...
Source: Toxicology in Vitro - November 16, 2012 Category: Toxicology Authors: Pfannenbecker U, Bessou-Touya S, Faller C, Harbell J, Jacob T, Raabe H, Tailhardat M, Alépée N, De Smedt A, De Wever B, Jones P, Kaluzhny Y, Le Varlet B, McNamee P, Marrec-Fairley M, Van Goethem F Tags: Toxicol In Vitro Source Type: research

Olfactory recovery of wild yellow perch from metal contaminated lakes.
In this study, we used electro-olfactography (EOG) to measure the olfactory acuity of wild yellow perch (Perca flavescens) from a clean lake (Geneva Lake) and two metal contaminated lakes (Ramsey and Hannah lakes) from Sudbury, ON, in their own lake water or in water from the other lakes. The results showed that fish from the clean lake had a greater olfactory acuity than those from metal contaminated lakes when fish were tested in their own lake water. However, when fish from the clean lake were held for 24h in water from each of the two contaminated lakes their olfactory acuity was diminished. On the other hand, fish fro...
Source: Ecotoxicology and Environmental Safety - November 16, 2012 Category: Environmental Health Authors: Azizishirazi A, Dew WA, Forsyth HL, Pyle GG Tags: Ecotoxicol Environ Saf Source Type: research

An Uncommon Malignancy of the Esophagus
Question: A previously healthy, 56-year-old man visited our hospital with a 2-month history of dysphagia. The patient's past medical history was unremarkable. He denied a recent history of weight loss, reflux symptoms, or food impaction. Laboratory and physical test results revealed no abnormalities. Barium swallow esophagogram showed dilatation of the esophagus with a filling defect, approximately 7 cm long, in the intrathoracic esophagus (A). Endoscopy also revealed an elastic and large polypoid tumor occupying the almost whole lumen in the mid-esophagus (Figure B). Despite such a bulky appearance, the lesion allowed eas...
Source: Gastroenterology - November 16, 2012 Category: Gastroenterology Authors: Kensuke Adachi, Kazuaki Enatsu Tags: Clinical Challenges and Images in GI Source Type: research

Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk
Conclusions: Serum cholesterol, HDL-cholesterol and triglycerides can be used to compute clinically useful estimates of apoB and apoA1. Using this methodology, estimates of apolipoproteins could be routinely added to laboratory reports to complement lipoprotein lipids in risk assessment.Highlights: ► Computational method was developed to estimate apoB and apoA1 from basic lipids. ► These estimates correlate with measured apolipoproteins. ► These estimates predict increased carotid IMT. ► These estimates could be easily added to routine laboratory reports.
Source: Atherosclerosis - November 16, 2012 Category: Cardiology Authors: Olli T. Raitakari, Ville-Petteri Mäkinen, Matthew J. McQueen, Jaakko Niemi, Markus Juonala, Matti Jauhiainen, Veikko Salomaa, Minna L. Hannuksela, Markku J. Savolainen, Y. Antero Kesäniemi, Petri T. Kovanen, Jouko Sundvall, Tiina Solakivi, Britt-Marie L Tags: Epidemiology, Biomarkers, Nutrition Source Type: research

Validation of a novel sham cervical manipulation procedure
Conclusions: The novel sham procedure has been shown to be effective in masking subjects to group allocation and to be clinically inert with respect to common outcomes in the immediate posttreatment stage. Further research on serial applications and for multiple operators is warranted.
Source: The Spine Journal - November 16, 2012 Category: Orthopaedics Authors: Howard T. Vernon, John J. Triano, James K. Ross, Steven K. Tran, David M. Soave, Maricelle D. Dinulos Tags: Clinical Studies Source Type: research

Total and High-Molecular-Weight Adiponectin and Risk of Coronary Heart Disease and Ischemic Stroke in Older Adults.
Conclusion:In community-living elders, total and HMW adiponectin showed similar U-shaped relationships with CVD. The inverse relation in the lower range, but not the direct association at the higher end, disappeared after inclusion of putative intermediates, suggesting that high levels may reflect adverse processes separate from adiponectin's beneficial glycometabolic properties. PMID: 23162097 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - November 16, 2012 Category: Endocrinology Authors: Kizer JR, Benkeser D, Arnold AM, Djousse L, Zieman SJ, Mukamal KJ, Tracy RP, Mantzoros CS, Siscovick DS, Gottdiener JS, Ix JH Tags: J Clin Endocrinol Metab Source Type: research

Validation of the Volumetric Measurement of a Simulated Maxillary Alveolar Bone Defect Using Cone-Beam Computed Tomography.
Conclusions : 3D volumetric measurement of simulated alveolar bone defects using i-CAT CBCT scans is similar to the volumes determined using micro-CT. PMID: 23157577 [PubMed - as supplied by publisher]
Source: The Cleft Palate-Craniofacial Journal - November 16, 2012 Category: ENT & OMF Authors: Ivekovic S, McIntyre GT, Gillgrass T, Thomson DA, Menhinick A, Mossey PA Tags: Cleft Palate Craniofac J Source Type: research

Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy.
Abstract Intravital microscopy of the pulmonary microcirculation in research animals is of great scientific interest for its utility in identifying regional changes in pulmonary microcirculatory blood flow. Although feasibility studies have been reported, the pulmonary window can be further refined into a practical tool for pharmaceutical research and drug development. We have established a method to visualize and quantify dynamic changes in three key features of lung function: microvascular red blood cell velocity, flow direction and hemoglobin saturation. These physiologic parameters were measured in an acute clo...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 16, 2012 Category: Cytology Authors: Hanna G, Fontanella A, Palmer G, Shan S, Radiloff DR, Zhao Y, Irwin DC, Hamilton KL, Boico A, Piantadosi CA, Blueschke G, Dewhirst MW, McMahon TJ, Schroeder T Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Transcranial magnetic resonance-guided focused ultrasound surgery for trigeminal neuralgia: a cadaveric and laboratory feasibility study.
Conclusions This study demonstrates focal heating of up to 18°C in a cadaveric trigeminal nerve at the REZ and along the cisternal segment with transcranial MRgFUS. Significant heating of the skull base and surrounding neural structures did not occur with implementation of no-pass regions. However, in vivo studies are necessary to confirm the safety and efficacy of this potentially new, noninvasive treatment. PMID: 23157185 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 16, 2012 Category: Neurosurgery Authors: Monteith SJ, Medel R, Kassell NF, Wintermark M, Eames M, Snell J, Zadicario E, Grinfeld J, Sheehan JP, Elias WJ Tags: J Neurosurg Source Type: research

New methods for the concentration of viruses from urban sewage using quantitative PCR.
Abstract Viruses are among the most important pathogens present in water contaminated with feces or urine and represent a serious risk to human health. Four procedures for concentrating viruses from sewage have been compared in this work, three of which were developed in the present study. Viruses were quantified using PCR techniques. According to statistical analysis and the sensitivity to detect human adenoviruses (HAdV), JC polyomaviruses (JCPyV) and noroviruses genogroup II (NoV GGII), (i) a new procedure (elution and skimmed-milk flocculation procedure (ESMP)) based on the elution of the viruses with glycine-a...
Source: Journal of Virological Methods - November 16, 2012 Category: Virology Authors: Calgua B, Rodriguez-Manzano J, Hundesa A, Suñen E, Calvo M, Bofill-Mas S, Girones R Tags: J Virol Methods Source Type: research

Differential gene expression profile of the calanoid copepod, Pseudodiaptomous annandalei, in response to nickel exposure.
Abstract To better understand the underlying mechanisms of reactions of copepods exposed to elevated level of nickel, the suppression subtractive hybridization (SSH) was used to elucidate the response of the copepod Pseudodiaptomous annandalei to nickel exposure at the gene level. P. annandale is one of a few copepod species that can be cultured relatively easy under laboratory condition, and it is considered to be a potential model species for toxicity study. In the present study, P. annandalei were exposed to nickel at a concentration of 8.86mgL(-1) for 24h, after which the RNA was prepared for SSH using unexpose...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - November 16, 2012 Category: Biochemistry Authors: Jiang JL, Wang GZ, Mao MG, Wang KJ, Li SJ, Zeng CS Tags: Comp Biochem Physiol C Toxicol Pharmacol Source Type: research

Conscious Correction of Scapular Orientation in Overhead Athletes Performing Selected Shoulder Rehabilitation Exercises: The Effect on Trapezius Muscle Activation Measured by Surface Electromyography.
CONCLUSIONS: Conscious correction of scapular orientation during the prone extension and side-lying external rotation exercise can be used to increase the activation level in the 3 sections of the trapezius in overhead athletes with scapular dyskinesis. Although lack of kinematic data limits the interpretation of the results, this study suggests that conscious correction of scapular orientation can be performed without altering the favorable UT/MT and UT/LT ratios which have been previously reported for these exercises. J Orthop Sports Phys Ther, Epub 16 November 2012. doi:10.2519/jospt.2013.4283. PMID: 23160271 [PubMe...
Source: Physical Therapy - November 16, 2012 Category: Physiotherapy Authors: De Mey K, Danneels LA, Cagnie B, Huyghe L, Seyns E, Cools AM Tags: J Orthop Sports Phys Ther Source Type: research

Clinimetric Analysis of Pressure Biofeedback and Transversus Abdominis Function in Individuals With Stabilization Classification Low Back Pain.
CONCLUSIONS: Successful completion on pressure biofeedback does not indicate high TrA activation. Unsuccessful completion on pressure biofeedback maybe more indicative of low TrA activation, but the correlation and likelihood coefficients indicate the pressure test is likely of minimal value to detect TrA activation.J Orthop Sports Phys Ther, Epub 16 November 2012. doi:10.2519/jospt.2013.4397. PMID: 23160344 [PubMed - as supplied by publisher]
Source: Physical Therapy - November 16, 2012 Category: Physiotherapy Authors: Grooms DR, Grindstaff TL, Croy T, Hart JM, Saliba SA Tags: J Orthop Sports Phys Ther Source Type: research

Which Exercises Target the Gluteal Muscles While Minimizing Activation of the Tensor Fascia Lata? Electromyographic Assessment Using Fine-Wire Electrodes.
CONCLUSION: If the goal of rehabilitation is to preferentially activate the gluteal muscles while minimizing TFL activation, then the clam, side-step, unilateral bridge, and both quadruped hip extension exercises would appear to be most appropriate.J Orthop Sports Phys Ther, Epub 16 November 2012. doi:10.2519/jospt.2013.4116. PMID: 23160432 [PubMed - as supplied by publisher]
Source: Physical Therapy - November 16, 2012 Category: Physiotherapy Authors: Selkowitz DM, Beneck GJ, Powers CM Tags: J Orthop Sports Phys Ther Source Type: research

Referral centre variation in requesting JAK2 V617F mutation analysis for the investigation of a myeloproliferative neoplasm
The discovery of the JAK2 V617F mutation has undoubtedly revolutionised the diagnosis of the classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) with the mutation present in greater than 95% of polycythaemia vera (PV) patients, approximately 50% of patients with essential thrombocythaemia (ET) and primary myelofibrosis (PMF) and, to a lesser degree, in a number of other myeloid malignancies such as refractory anaemia with ringed sideroblasts with thrombocytosis, chronic myelomonocytic leukaemia and acute myeloid leukaemia. Detection of this mutation is beneficial in differentiating between ...
Source: Journal of Clinical Pathology - November 16, 2012 Category: Pathology Authors: Langabeer, S. E. Tags: PostScript Source Type: research

Mitochondrial encephalopathy in a patient with a 13042G>A de novo mutation
Mitochondrial DNA point mutations are associated with various syndromes, among which mitochondrial myopathy, encephalopathy, lactic acidosis and stroke (MELAS) and myoclonic epilepsy with ragged red fibres (MERRF) are the most common.1 Here we present a case report of a young man with a mitochondrial encephalomyopathy caused by a mutation in the ND5 gene (13042A>G), which has been described previously.1 A 21-year-old man presented with a 2-year history of recurrent generalised epileptic seizures and myoclonus with no family history. Neurological examination revealed discrete nystagmus and multifocal myoclonus in the upp...
Source: Journal of Clinical Pathology - November 16, 2012 Category: Pathology Authors: Slawek, J., Kierdaszuk, B., Tonska, K., Kodron, A., Schinwelski, M., Sitek, E. J., Bartnik, E., Kaminska, A., Kwiecinski, H. Tags: PostScript Source Type: research

Variation in postmortem liver sampling: implications for postmortem toxicology interpretation
Conclusions The published guidelines for liver sampling were either not known or not being followed by pathologists. Although this did not directly affect any of the cases audited, such a lack of knowledge of the recommended site of liver sampling may lead to incorrect interpretation if the site of liver sample is unknown by the receiving laboratory.
Source: Journal of Clinical Pathology - November 16, 2012 Category: Pathology Authors: Morley, S. R., Bolton, J. Tags: Short reports Source Type: research

Abnormalities of serum-free light chain in patients with primary antibody deficiency in the absence of B lymphocyte clonality
Conclusions The data suggest that the abnormal ratios are generated by an inability to produce and/or secrete SFLCs, particularly kappa FLC. In this small initial study, we seek to highlight PAD cases where a suspicious K/L ratio, typically with very low absolute quantities of SFLCs, most likely points to B-cell dysfunction, rather than to B lymphocyte clonality.
Source: Journal of Clinical Pathology - November 16, 2012 Category: Pathology Authors: Unsworth, D. J., Wallage, M. J., Sarkar, E., Lock, R. J. Tags: Immunology (including allergy) Original articles Source Type: research

Point of Care INR testing devices: performance of the Roche CoaguChek XS and XS Plus in the UK NEQAS BC external quality assessment programme for healthcare professionals: four years' experience
Conclusions Utilisation of an EQA programme for POC devices in primary care is feasible and necessary. Our data suggest for those health professionals using EQA, the reliability and accuracy of INR testing matches the quality of laboratory testing.
Source: Journal of Clinical Pathology - November 16, 2012 Category: Pathology Authors: Kitchen, D. P., Kitchen, S., Jennings, I., Woods, T. A., Fitzmaurice, D. A., Murray, E. T., Walker, I. D. Tags: Original articles Source Type: research

Whole slide images as a platform for initial diagnostics in histopathology in a medium-sized routine laboratory
Conclusion The quality of the currently produced WSI is sufficient for primary diagnostics in 82.1% of the cases. Improving image quality, adequate retrieval and controlling scanning error will definitely encourage the wide adaptation in routine diagnostics.
Source: Journal of Clinical Pathology - November 16, 2012 Category: Pathology Authors: Al-Janabi, S., Huisman, A., Nap, M., Clarijs, R., van Diest, P. J. Tags: Breast cancer, Histopathology, Clinical diagnostic tests Original articles Source Type: research

The prevalence and clinicopathological profile of IgM nephropathy in children with steroid-resistant nephrotic syndrome at a single centre in Pakistan
Conclusions IgMN is a common cause of paediatric SRNS and is significantly different from MCD. There is also a significant difference in clinical and laboratory parameters among responders and non-responders to CNI in IgMN.
Source: Journal of Clinical Pathology - November 16, 2012 Category: Pathology Authors: Shakeel, S., Mubarak, M., Kazi, J. I., Lanewala, A. Tags: Immunology (including allergy), Chronic renal failure, Proteinurea, Clinical diagnostic tests Original articles Source Type: research

Validation of a Gene Expression Signature for Assessment of Lymph Node Metastasis in Oral Squamous Cell Carcinoma [Head and Neck Cancer]
Conclusion Combining current clinical assessment with the expression signature would decrease the rate of undetected nodal metastases from 28% to 11% in early-stage OSCC. This should be sufficient to enable clinicians to refrain from elective neck treatment. A new clinical decision model that incorporates the expression signature is therefore proposed for testing in a prospective study, which could substantially improve treatment for this group of patients.
Source: Journal of Clinical Oncology - November 16, 2012 Category: Cancer & Oncology Authors: van Hooff, Leusink, Roepman, Baatenburg de Jong, Speel, van den Brekel, van Velthuysen, van Diest, van Es, Merkx, Kummer, Leemans, Schuuring, Langendijk, Lacko, De Herdt, Jansen, Brakenhoff, Slootweg, Takes, Holstege Tags: Surgery, Translational Oncology, Diagnosis & Staging, H&N, Cancer Biomarkers, Gene Expression and Profiling, Invasion & Metastasis Head and Neck Cancer Source Type: research

The heritable basis and cost of colour plasticity in coastrange sculpins
Abstract Both genetic and plastic traits contribute to adaptation in novel environments. Phenotypic plasticity can facilitate adaptation by allowing for existence in a wider range of conditions and a faster response to environmental change than gene‐based selection. Coastrange sculpins (Cottus aleuticus) colonize new and variable streams arising in the wake of receding glaciers in south‐east Alaska, and substrate‐matching plasticity may enhance colonization success by reducing detection by visual predators. As part of a long‐term study of the fitness consequences of colour plasticity and its capacity to respond to ...
Source: Journal of Evolutionary Biology - November 16, 2012 Category: Biology Authors: C. A. Bergstrom, A. R. Whiteley, D. A. Tallmon Tags: Research Paper Source Type: research

Hematopoietic stem cell derived carcinoma-associated fibroblasts: a novel origin.
Abstract Researchers have begun to appreciate the significant role that the microenvironment plays in tumorigenesis and are now shedding light on the role of the stroma in induction and progression of solid tumors. While the stroma of solid tumors is comprised of many cell types, including vascular and immune cells, one of the most prominent cell types in the tumor stroma is the fibroblast, called the carcinoma-associated fibroblast (CAF) or tumor-associated fibroblast (TAF). The interaction between CAFs and tumor cells is quite complex. CAFs have been implicated in tumor angiogenesis, immunosuppression, tumor cell...
Source: International Journal of Clinical and Experimental Pathology - November 15, 2012 Category: Pathology Authors: McDonald LT, Larue AC Tags: Int J Clin Exp Pathol Source Type: research

Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis.
In this study, the author reviewed 15 cases of endometrioid adenocarcinoma of the ovary in the last 15 years of our pathology laboratory in search for the presence of endometriosis within the tumor. Six (40%) of the 15 endometrioid adenocarcinoma were found to have endometriosis in the tumor. All of the endometriosis were atypical. The age of the 6 patients ranged from 44 year to 78 year with a median of 59 years. Grossly, the endometrial adenocarcinomas with endometriosis were characterized by unilocular cystic tumors in 5 cases and multilocular cystic tumor in one case. Histologically, the grade of endometrioid carcinoma...
Source: International Journal of Clinical and Experimental Pathology - November 15, 2012 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Long Term Mortality Following Blood Stream Infection
We describe factors affecting mortality up to three years after bloodstream infection in a cohort of patients reviewed at the bedside by an infection specialist. Patients seen by our infectious diseases department's bacteraemia service between June 2005 and November 2008 were included in analyses. Routinely collected clinical data at the time of consultation, together with laboratory, demographic and outcome data were analysed to identify factors predicting death at 30 days and 3 years post bloodstream infection. Cox regression models for both time points were constructed, together with Kaplan Meier survival curves. 322 bl...
Source: Clinical Microbiology and Infection - November 15, 2012 Category: Microbiology Authors: Patrick J Lillie, Joanna Allen, Charlotte Hall, Chloe Walsh, Kate Adams, Hiten Thaker, Peter Moss, Gavin D Barlow Tags: Original Article Source Type: research

Increased level of platelet P-selectin in nonarteritic anterior ischemic optic neuropathy
Conclusion Elevated platelet CD62 positivity may be related to NAION, suggesting a possible role of enlarged platelet activity in the generation of this type of ischemic optic neuropathy. Content Type Journal ArticleCategory NeurophthalmologyPages 1-6DOI 10.1007/s00417-012-2196-0Authors Valeria Nagy, Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, 4012 Debrecen, HungaryBence Kolozsvari, Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, 4012 Debrecen, HungaryZsuzsa Balogh, Department of ...
Source: Graefe's Archive for Clinical and Experimental Ophthalmology - November 15, 2012 Category: Opthalmology Tags: Graefe's Archive for Clinical and Experimental Ophthalmology Source Type: research

The molecular basis of induction and formation of tunneling nanotubes
Abstract Tunneling nanotubes (TNTs) and associated structures are recently recognized structures for intercellular communication. They are F-actin-containing thin protrusions of the plasma membrane of a cell and allow a direct physical connection to the plasma membranes of remote cells. TNTs and associated structures serve as mediators for intercellular transfer of organelles as well as membrane components and cytoplasmic molecules. Moreover, several pathogens have been shown to exploit these structures to spread among cells. Because of their contribution to normal cellular functions and importance in pathol...
Source: Cell and Tissue Research - November 15, 2012 Category: Cytology Tags: Cell and Tissue Research Source Type: research

Sustained and differential antibody responses to virulence proteins of Brucella melitensis during acute and chronic infections in human brucellosis
In this study, a protein microarray was used to evaluate the antibody responses of brucellosis patients at different infection stages. A total of 107 outer membrane proteins, surface-exposed or secreted proteins, and known or putative virulence-associated proteins of B. melitensis were successfully expressed in Escherichia coli and used to fabricate the protein microarray. Then, 99 serum samples from acute, chronic, primary infection, or relapse brucellosis patients were probed with the protein microarray. Antibodies to 66 of the proteins were detected at least in one serum sample. Among the antigens, the combination o...
Source: European Journal of Clinical Microbiology and Infectious Diseases - November 15, 2012 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: research

Patient Completion of Laboratory Tests to Monitor Medication Therapy: A Mixed-Methods Study
CONCLUSIONS Patient non-completion contributed to missed opportunities to monitor medications, and was associated with younger patient age, lower medication burden and black box warning status. Interventions to improve laboratory monitoring should target patients as well as physicians. Content Type Journal ArticleCategory Original ResearchPages 1-9DOI 10.1007/s11606-012-2271-6Authors Shira H. Fischer, Beth Israel Deaconess Medical Center, Division of Clinical Informatics, 1330 Beacon St., Suite 400, Brookline, MA 02446, USATerry S. Field, Meyers Primary Care Institute, A Joint Endeavor of University...
Source: Journal of General Internal Medicine - November 15, 2012 Category: Internal Medicine Tags: Journal of General Internal Medicine Source Type: research

The Correlation Between Clinical Prediagnosis and Pathology Results in the Diagnosis of Neck Masses
Abstract The importance of clinical assessment and its contribution to the diagnosis of neck masses was investigated in patients presenting with a neck mass. In our study, we collected the medical history of a total of 127 patients, including 66 males and 61 females, who presented with a neck mass. Physical exams, endoscopic examinations, laboratory tests, a variety of imaging studies, and fine-needle aspiration biopsies were performed. The relationship between age, duration and location of the neck mass, FNAB results, and definitive histopathological diagnosis were investigated as well as the correlation be...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - November 15, 2012 Category: ENT & OMF Tags: Indian Journal of Otolaryngology and Head & Neck Surgery Source Type: research

Correlates of Unprotected Vaginal or Anal Intercourse with Women Among Substance-Using Men Who Have Sex with Men
Abstract The role men who have sex with men and women (MSMW) play in heterosexual HIV transmission is not well understood. We analyzed baseline data from Project MIX, a behavioral intervention study of substance-using men who have sex with men (MSM), and identified correlates of unprotected vaginal intercourse, anal intercourse, or both with women (UVAI). Approximately 10 % (n = 194) of the men reported vaginal sex, anal sex, or both with a woman; of these substance-using MSMW, 66 % (129) reported UVAI. Among substance-using MSMW, multivariate analyses found unemployment relative to full/p...
Source: AIDS and Behavior - November 15, 2012 Category: Infectious Diseases Tags: AIDS and Behavior Source Type: research

Associations between toxic metals in follicular fluid and in vitro fertilization (IVF) outcomes
Conclusions We have identified associations between trace amounts of Pb and Cd in FF from a single follicle, and oocyte fertilization. Yet, the likelihood of biological variation in trace element concentrations within and between follicles, coupled with levels that are near the limits of detection suggest that future work should examine multiple follicles using a ‘one follicle-one oocyte/embryo’ approach. A larger study is merited to assess more definitively the role that these environmental factors could play with respect to egg quality in IVF programs. Content Type Journal ArticleCategory ASSI...
Source: Journal of Assisted Reproduction and Genetics - November 15, 2012 Category: Reproduction Medicine Tags: Journal of Assisted Reproduction and Genetics Source Type: research

Synthesis, molecular modeling, and biological evaluation of 1,2,4-triazole derivatives containing pyridine as potential anti-tumor agents
Abstract There is an accumulating body of experimental evidences validating focal adhesion kinase (FAK) as a therapeutic target and offering opportunities for anti-tumor drug development. In present study, we sought to synthesize twenty-eight potential FAK inhibitors as anti-tumor agents based on 1,2,4-triazole skeleton. The bioassay assays demonstrated that compounds 3e and 6j showed the most potent activity, 3e inhibited the growth of HCT116 and HepG2 cell lines with IC50 values of 8.17 and 7.04 μM, while compound 6j showed the most potent biological activity against HCT116 cell line (IC50 = ...
Source: Medicinal Chemistry Research - November 15, 2012 Category: Chemistry Tags: Medicinal Chemistry Research Source Type: research

Azithromycin in combination with riboflavin decreases the severity of Staphylococcus aureus infection induced septic arthritis by modulating the production of free radicals and endogenous cytokines
Conclusion These changes were found to be ameliorated when the animals were co-treated with azithromycin and riboflavin. Content Type Journal ArticleCategory Original Research PaperPages 1-15DOI 10.1007/s00011-012-0574-zAuthors Pinky Mal, Department of Physiology, Immunology Laboratory, University of Calcutta, University Colleges of Science and Technology, 92 APC Road, Calcutta, 700009 West Bengal, IndiaKallol Dutta, National Brain Research Centre, Manesar, Haryana 122051, IndiaDebasish Bandyopadhyay, Department of Physiology, Oxidative Stress and Free Radical Biology Laboratory, University of Calcutta,...
Source: Inflammation Research - November 15, 2012 Category: Research Tags: Inflammation Research Source Type: research

Histone deacetylase inhibitors stimulate tissue-type plasminogen activator production in vascular endothelial cells
Abstract A reduced capacity for acute tissue-type plasminogen activator (t-PA) release is likely to be associated with an impaired endogenous defense against intravascular thrombosis. Efficient approaches to pharmacologically restore a defective t-PA release have been lacking, but recent observations suggest that histone deacetylase inhibitors (HDACis) enhance t-PA production in vitro. HDACis have diverse chemical structures and different HDAC-enzyme sub-class targeting. We here compared the effects of several clinically used HDACis on t-PA production in endothelial cells. Human umbilical vein endothelial ce...
Source: Journal of Thrombosis and Thrombolysis - November 15, 2012 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: research

Field and Laboratory Simulation Study of Hot Spots in Stockpiled Bituminous Coal
Energy & FuelsDOI: 10.1021/ef301474t
Source: Energy and Fuels - November 15, 2012 Category: Chemistry Authors: Uri Green, Zeev Aizenshtat, Lionel Metzger and Haim Cohen Source Type: research

Ability of Triage Decision Rules for Rapid Electrocardiogram to Identify Patients With Suspected ST-Elevation Myocardial Infarction
Conclusions: The Graff ECG triage rule identified almost all patients for whom the CCL was activated. Modification of the rule as proposed by Glickman added very little to the rule’s sensitivity, while increasing the number of ECGs required at triage.
Source: Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine - November 15, 2012 Category: Cardiology Tags: Original Articles Source Type: research

Clinical Pathway: Helicopter Scene STEMI Protocol to Facilitate Long-Distance Transfer for Primary PCI
Conclusions: In our single-center experience, 22 scene STEMI patients were diagnosed and appropriately triaged by EMS to our center for primary PCI. Our data show feasibility of an EMS-activated STEMI network over long distances with good reperfusion times.
Source: Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine - November 15, 2012 Category: Cardiology Tags: Pathway Source Type: research

Recommendations for Management of Antiplatelet Therapy in Patients Undergoing Elective Noncardiac Surgery After Coronary Stent Implantation
Patients commonly undergo noncardiac surgical procedures after implantation of a coronary stent. In the case where surgery cannot be deferred until completing the minimum duration of dual antiplatelet therapy, the Brigham and Women’s Hospital Cardiac Catheterization Laboratory recommends using a glycoprotein IIb/IIIa bridging protocol to minimize the risk of perioperative ischemic events. We discuss our algorithm for managing antiplatelet agents, including the newer agents, prasugrel and ticagrelor, in patients undergoing noncardiac surgery after coronary stenting and present our glycoprotein IIb/IIIa bridging strategy a...
Source: Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine - November 15, 2012 Category: Cardiology Tags: Pathway Source Type: research

Atomic engineering of platinum alloy surfaces.
Abstract A major practical challenge in heterogeneous catalysis is to minimize the loading of expensive platinum group metals (PGMs) without degrading the overall catalytic efficiency. Gaining a thorough atomic-scale understanding of the chemical/structural changes occurring during catalyst manufacture/operation could potentially enable the design and production of "nano-engineered" catalysts, optimized for cost, stability and performance. In the present study, the oxidation behavior of a Pt-31 at% Pd alloy between 673-1073K is investigated using atom probe tomography (APT). Over this range of temperatures, three m...
Source: Ultramicroscopy - November 15, 2012 Category: Laboratory Medicine Authors: Li T, Bagot PA, Marquis EA, Edman Tsang SC, Smith GD Tags: Ultramicroscopy Source Type: research

Effect of water activity and temperature on the germination and growth of Aspergillus tamarii isolated from "Maldive fish".
Abstract Germination times and radial growth rates of cyclopiazonic acid producing strains of Aspergillus tamarii isolated from a smoked dried fish product were studied over water activities (a(w)) ranging from 0.99 to 0.79 at 25°C, 30°C, 35°C and 40°C on two laboratory media. The a(w) of the media was controlled by either NaCl or a mixture of glucose and fructose. The optimum germination and growth were observed at temperatures between 30°C and 35°C. Germination was favored at the highest a(w) of 0.99 under all conditions. Growth however was dependent on the media and temperature with a lower optimum a(w) of...
Source: International Journal of Food Microbiology - November 15, 2012 Category: Food Science Authors: Mohamed S, Mo L, Flint S, Palmer J, Fletcher GC Tags: Int J Food Microbiol Source Type: research

Cancer Stem Cells: A Review of Potential Clinical Applications.
Conclusions.-Despite a lack of consensus in the scientific community on research methodology, CSCs have demonstrated significant potential as therapeutic targets in the treatment of cancer. Further research of CSC biology and markers will eventually lead to the development of novel therapeutic approaches for targeting these cells to treat resistant and recurrent tumors and minimal residual disease. PMID: 23153183 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - November 15, 2012 Category: Laboratory Medicine Authors: Podberezin M, Wen J, Chang CC Tags: Arch Pathol Lab Med Source Type: research

Safety and efficacy of ARA290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double blind, pilot study.
Abstract ARA290, a peptide designed to activate the innate repair receptor that arrests injury and initiates cytoprotection, anti-inflammation, and healing, reduces allodynia in preclinical neuropathy models. We studied the safety and efficacy of ARA 290 to reduce symptoms of small fiber neuropathy (SFN) in patients with sarcoidosis. Twenty two patients diagnosed with sarcoidosis and symptoms of SFN were enrolled in a double blind, placebo-controlled exploratory trial of three times weekly intravenous dosing of ARA 290 (2 mg; n=12) or placebo (n=10) for 4 weeks. Inclusion criteria were a diagnosis of neuropathy and...
Source: Molecular Medicine - November 15, 2012 Category: Molecular Biology Authors: Heij L, Niesters M, Swartjes M, Hoitsma E, Drent M, Dunne A, Grutters JC, Vogels O, Brines M, Cerami A, Dahan A Tags: Mol Med Source Type: research

Chiral signature of venlafaxine as a marker of biological attenuation processes.
Abstract The chiral signature of the antidepressant venlafaxine was used in this study to gain insight into biological attenuation processes and to differentiate abiotic and biotic transformation processes in water. Laboratory scale experiments revealed that sorption and phototransformation processes were not enantioselective while venlafaxine was enantioselectively biotransformed into O-desmethylvenlafaxine. The enantiomeric fraction (EF) variations of venlafaxine appeared to be proportional to its microbial fractional conversion. Enantioselective biotransformation of venlafaxine was also investigated in a eutroph...
Source: Chemosphere - November 15, 2012 Category: Chemistry Authors: Li Z, Gomez E, Fenet H, Chiron S Tags: Chemosphere Source Type: research

Degradation of lidocaine, tramadol, venlafaxine and the metabolites O-desmethyltramadol and O-desmethylvenlafaxine in surface waters.
Abstract The photodegradation and biotic transformation of the pharmaceuticals lidocaine (LDC), tramadol (TRA) and venlafaxine (VEN), and of the metabolites O-desmethyltramadol (ODT) and O-desmethylvenlafaxine (ODV) in the aquatic environmental have been investigated. Photodegradation experiments were carried out using a medium pressure Hg lamp (laboratory experiments) and natural sunlight (field experiments). Degradation of the target compounds followed a first-order kinetic model. Rates of direct photodegradation (light absorption by the compounds itself) at pH 6.9 were very low for all of the target analytes (�...
Source: Chemosphere - November 15, 2012 Category: Chemistry Authors: Rúa-Gómez PC, Püttmann W Tags: Chemosphere Source Type: research

Using the HIV Surveillance System to Monitor the National HIV/AIDS Strategy.
Conclusions. The findings highlight disparities in access to and success of care. (Am J Public Health. Published online ahead of print November 15, 2012: e1-e7. doi:10.2105/AJPH.2012.300859). PMID: 23153150 [PubMed - as supplied by publisher]
Source: American Journal of Public Health - November 15, 2012 Category: Global & Universal Authors: Mahle Gray K, Tang T, Shouse L, Li J, Mermin J, Hall HI Tags: Am J Public Health Source Type: research

A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data.
Abstract 1. Focusing on the genetic similarity of CYP3A subfamily enzymes (CYP3A4 and CYP3A5) between monkeys and humans, we have attempted to provide a single-species approach to predicting human hepatic clearance (CL(h)) of CYP3A4 substrates using pharmacokinetic parameters in cynomolgus monkeys following intravenous administrations. 2. Hepatic intrinsic clearance (CL(int,h)) of six CYP3A4 substrates (alprazolam, clonazepam, diltiazem, midazolam, nifedipine, and quinidine), covering a wide range of clearance, in monkeys correlated well with that cited in literature for humans (R = 0.90) with a simple equation of...
Source: Xenobiotica - November 15, 2012 Category: Research Authors: Ogawa K, Kato M, Houjo T, Ishigai M Tags: Xenobiotica Source Type: research

Markers of circulating tumour cells in the peripheral blood of patients with melanoma correlate with disease recurrence and progression
Conclusions Circulating tumour cells were detectable at all stages of disease and long after surgical treatment, even when patients were considered disease free. Specifically, expression of ABCB5 and MLANA had significant prognostic value in inferring disease recurrence, while MCAM expression was associated with poor patient outcome after treatment, confirming multimarker qRT‐PCR as a potential technique for monitoring disease status.
Source: British Journal of Dermatology - November 15, 2012 Category: Dermatology Authors: A.L. Reid, M. Millward, R. Pearce, M. Lee, M.H. Frank, A. Ireland, L. Monshizadeh, T. Rai, P. Heenan, S. Medic, P. Kumarasinghe, M. Ziman Tags: CLINICAL AND LABORATORY INVESTIGATIONS Source Type: research

Haemostatic monitoring during postpartum haemorrhage and implications for management
Postpartum haemorrhage (PPH) is a major risk factor for maternal morbidity and mortality. PPH has numerous causative factors, which makes its occurrence and severity difficult to predict. Underlying haemostatic imbalances such as consumptive and dilutional coagulopathies may develop during PPH, and can exacerbate bleeding and lead to progression to severe PPH. Monitoring coagulation status in patients with PPH may be crucial for effective haemostatic management, goal-directed therapy, and improved outcomes. However, current PPH management guidelines do not account for the altered baseline coagulation status observed in pre...
Source: British Journal of Anaesthesia - November 15, 2012 Category: Anesthesiology Authors: Solomon, C., Collis, R. E., Collins, P. W. Tags: Review Articles Source Type: research