Laboratory Medicine Top 20This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

PrefaceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Respiratory viruses continue to be a fascinating subject. The mutability of these viruses leads to the periodic emergence of new serotypes or species of viruses as human pathogens. Because these viruses are readily transmitted, a new respiratory virus that emerges can spread rapidly. The coronavirus associated with the severe acute respiratory syndrome (SARS) and the novel influenza A (H1N1) virus (swine influenza) are two examples of respiratory viruses that spread very quickly after emerging. According to data from the World Health Organization, there have been 55,867 cases and 238 deaths due to the H1N1 virus to date (h...
Source: Clinics in Laboratory Medicine - November 4, 2009 Category: Laboratory Medicine Authors: Alexander J. McAdam Source Type: journals

The prognostic utility of haptoglobin genotypes in squamous cell carcinoma of the head and neckEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present data show that the Hp genotype is closely related to recurrence rate in patients with HNSCC. Patients with Hp 2-2 or 2-0 have greater locoregional recurrence and significantly increased HRs in multivariate analysis. The Hp genotype may be a prognostic factor in patients with HNSCC. Clin Chem Lab Med 2009;47:1277–83. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Field effect in cancer-an update.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The concept "field effect in cancer" originated in 1953 from the histopathological observations of Slaughter and colleagues [1] regarding the occurrence of multiple primary oral squamous cell carcinomas and their local recurrences. The development of modern molecular technologies has extended the field effect concept by exploring the molecular abnormalities in tissues that appear histologically normal. To date, such field effect biomarkers have been reported in several sites and organs, eg, head and neck, colon and rectum, prostate, breast, lung, esophagus, stomach, and skin. Two popular hypotheses have been proposed. ...
Source: Annals of Clinical and Laboratory Science - November 3, 2009 Category: Laboratory Medicine Authors: Chai H, Brown RE Tags: Ann Clin Lab Sci Source Type: journals

Analysis of Aurora B kinase in non-Hodgkin lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Akihito Yokoyama (Source: Laboratory Investigation AOP)
Source: Laboratory Investigation AOP - October 11, 2009 Category: Laboratory Medicine Authors: Takayuki IkezoeTamotsu TakeuchiJing YangYoshihiro AdachiChie NishiokaMutsuo FurihataH Phillip KoefflerAkihito Yokoyama Source Type: journals

Two-photon microscopy of deep intravital tissues and its merits in clinical researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multiphoton excitation laser scanning microscopy, relying on the simultaneous absorption of two or more photons by a molecule, is one of the most exciting recent developments in biomedical imaging. Thanks to its superior imaging capability of deeper tissue penetration and efficient light detection, this system becomes more and more an inspiring tool for intravital bulk tissue imaging. Two-photon excitation microscopy including 2-photon fluorescence and second harmonic generated signal microscopy is the most common multiphoton microscopic application. In the present review we take diverse ocular tissues as intravital sample...
Source: Journal of Microscopy - October 21, 2009 Category: Laboratory Medicine Authors: B.-G. WANG, K. KÖNIG, K.-J. HALBHUBER Source Type: journals

Antigen-Based Assays for the Identification of Influenza Virus and Respiratory Syncytial Virus: Why and How to Use Them in Pediatric PracticeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes the clinical and socioeconomic relevance of influenza (IV) and respiratory syncytial virus (RSV) in pediatrics, the characteristics and limitations of currently available assays, and the impact of rapid diagnostic tests. This article shows that rapid tests for the detection and identification of IV and RSV in the respiratory secretions of infants and children are useful in the diagnosis of common, and possibly severe diseases, such as influenza and bronchiolitis. The tests' specificity and sensitivity make them most reliable when the prevalence of influenza or RSV infection is high, which suggests th...
Source: Clinics in Laboratory Medicine - November 4, 2009 Category: Laboratory Medicine Authors: Nicola Principi, Susanna Esposito Source Type: journals

Markers of infection in inpatients and outpatients with acute Q-feverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Acute Q-fever, a relatively mild pneumonia with low CURB-65 scores, specifically induces a response in CRP, while PCT concentrations and leukocytes are within the normal range or increased only marginally. Clin Chem Lab Med 2009;47:1407–9. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Hypoxia related growth factors and p53 in preoperative sera from patients with colorectal cancer – evaluation of the prognostic significance of these agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1439-1445 Abstract Background: Insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) belong to a group of hypoxia related proteins. IGF-I induces expression of VEGF and decomposes wild type p53 in cancer cell lines. The goal of our study was to evaluate serum IGF-I, VEGF and p53 with respect to overall and disease free survival of patients with colorectal cancer (CRC) patients compared with healthy volunteers. Methods: Preoperative blood samples from 125 patients with CRC and 16 healthy volunteers were examined using ELISA for serum IGF-I, p53...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Molecular diagnostics in acute leukemiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1333-1341 Abstract Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) both represent highly heterogeneous entities on the basis of diverse cyto- and molecular genetic alterations with considerable influence on prognosis and therapeutic decisions. In recent years, insights into the complex network of molecular markers underlying this diversity have shown marked progress due to the detection of novel mutations, such as nucleophosmin gene (NPM1) in AML, and due to the description of cooperation pathways in leukemogenesis. Also, targeted therapeutic strategie...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. Similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. Human papillomavirus-associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. The histopathology of this subset of head and neck squamous cell carcinoma is unique and typically characterized by poorly differentiated, nonkeratinizing morphology with a basaloid appearance. These tumor...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: McHugh JB Tags: Arch Pathol Lab Med Source Type: journals

Primary intraosseous squamous cell carcinoma of the jaws. Clinicopathologic presentation and prognostic factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Primary intraosseous squamous cell carcinoma is a high-grade malignancy with frequent, regional lymph node metastasis and high rates of recurrence and mortality. The tumor grading and regional lymph node metastasis may serve as useful indicators for prognosis. PMID: 19886720 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Huang JW, Luo HY, Li Q, Li TJ Tags: Arch Pathol Lab Med Source Type: journals

Haemophilus influenzae serotype a meningitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This work describes a case of Haemophilus influenzae serotype a meningitis in Brazil, after almost a decade since the introduction of Haemophilus influenzae serotype b conjugate vaccine. Uncertainty about the replacement of H. influenzae serotypes as a cause of invasive diseases justifies continuous surveillance, coupled with investigations of carriage rates and requirements of chemoprophylaxis in contact persons. PMID: 19880770 [PubMed - in process] (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - November 3, 2009 Category: Laboratory Medicine Authors: de Pádua RA, de Lima Scodro RB, Ghiraldi LD, Siqueira VL, Yamashita YK, Helbel C, Cardoso RF Tags: Ann Clin Lab Sci Source Type: journals

Acetaminophen combinations protect against iron-induced cardiac damage in gerbils.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study tested if acetaminophen, N-methyl-D-glucamine dithiocarbamate (NMGDTC), deferoxamine, and combinations of these agents reduce excess iron content, prevent iron-induced pathology, reduce cardiac arrhythmias, and reduce mortality in iron-overloaded gerbils. Eight groups of 16 gerbils received iron dextran injections (ferric hydroxide dextran complex, 120 mg/kg, ip) or saline solution (controls) twice/wk for 8 wk. The 8 groups were treated every Monday, Wednesday, and Friday with one of the following: saline control, acetaminophen, 150 mg/kg, ip), acetaminophen (150 mg/kg, po), deferoxamine, 83 mg/kg, ip), NMGDTC (...
Source: Annals of Clinical and Laboratory Science - November 3, 2009 Category: Laboratory Medicine Authors: Walker EM, Morrison RG, Dornon L, Laurino JP, Walker SM, Studeny M, Wehner PS, Rice KM, Wu M, Blough ER Tags: Ann Clin Lab Sci Source Type: journals

Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer. Most are sporadic, presenting as cutaneous tumors in the scalp/face of elderly patients. However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations. Predisposing conditions include environmental exposures to chemical or radioactive sources. Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy. The latency for radiation-associated mammary angiosarcoma is rel...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Lucas DR Tags: Arch Pathol Lab Med Source Type: journals

Primary bone lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary bone lymphomas are rare, even though secondary involvement of the bone marrow is a common event in systemic lymphomas. Most primary bone lymphomas are primary bone diffuse large B-cell lymphomas (PBDLBCLs) with a rare occurrence of follicular, marginal zone, anaplastic large cell, Hodgkin, and T-cell lymphomas. The PBDLBCL affects the middle-aged to elderly population, with a slight predominance in men. The patients present with bone pain, palpable mass, fractures, or neurologic symptoms. The metaphysis of bones is a common location of PBDLBCL. Morphologically, the lymphoma consists of a polymorphous mixture of...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Bhagavathi S, Fu K Tags: Arch Pathol Lab Med Source Type: journals

Enhanced bone metabolism in vegetarians – the role of vitamin B12 deficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Low vitamin B12 status is related to increased bone turnover in vegetarians which is independent from vitamin D status. Clin Chem Lab Med 2009;47:1381–7. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Sarcomatoid chromophobe renal cell carcinoma with heterologous sarcomatoid elements. A case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chromophobe renal cell carcinoma (CRCC) is a distinct subtype of renal cell carcinoma (RCC) that is well known for its relatively good prognosis. Sarcomatoid transformation in this tumor, although rare, has been well documented in the literature and, as in other types of RCC, carries an ominous prognosis for the patient. The finding of heterologous elements in the sarcomatoid component of CRCC is an extraordinary event, which has been reported in only 2 previous cases. Here, we present the third such case, occurring in the left kidney of a previously healthy 63-year-old woman. The nephrectomy specimen showed CRCC with ...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Authors: Quiroga-Garza G, Khurana H, Shen S, Ayala AG, Ro JY Tags: Arch Pathol Lab Med Source Type: journals

Immunotargeting of apolipoprotein E in amyloid: an initial trial in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study utilized a radiolabeled monoclonal antibody specific to human apolipoprotein E fragments and human apolipoprotein E-knock-in mice, in which AA amyloidosis was induced. Accumulation of the injected radiolabeled antibody was significantly higher in the organs of amyloidotic mice than in those of non-amyloidotic mice. Plasma clearance of the antibody did not differ between the amyloidotic and non-amyloidotic mice. The antibody was given to mice during amyloid induction but failed to prevent amyloidogenesis. The results of this initial study are encouraging, but considerable improvement is necessary, particularly in...
Source: Annals of Clinical and Laboratory Science - June 27, 2009 Category: Laboratory Medicine Authors: Yamada T, Someya T, Fujita S Tags: Ann Clin Lab Sci Source Type: journals

Respiratory Syncytial Virus Vaccine DevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Respiratory syncytial virus (RSV) is a clinically significant cause of respiratory tract disease, especially among high-risk infants and immunocompromised and elderly adults. Despite the burden of disease, there is no licensed prophylactic RSV vaccine. The initial efforts to develop an RSV vaccine involved formalin-inactivated virus preparations that unexpectedly caused vaccine-enhanced disease in clinical trials in RSV-naive children. Over the last 40 years, cautious and deliberate progress has been made toward RSV vaccine development using various experimental approaches, including live attenuated strains and vector-base...
Source: Clinics in Laboratory Medicine - November 4, 2009 Category: Laboratory Medicine Authors: Yoshihiko Murata Source Type: journals

Respiratory Viruses in Bronchiolitis and Their Link to Recurrent Wheezing and AsthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bronchiolitis is the leading cause of hospitalization for children younger than 1 year of age and these hospitalized children have an increased risk for developing childhood asthma. It remains unclear, however, which children who have severe bronchiolitis (eg, an episode requiring hospitalization) will develop recurrent wheezing or asthma. Although many environmental and genetic factors may play a role in the pathway from bronchiolitis to asthma, this article focuses on the viruses that have been linked to bronchiolitis and how these viruses may predict or contribute to future wheezing and asthma. The article also discusse...
Source: Clinics in Laboratory Medicine - November 4, 2009 Category: Laboratory Medicine Authors: Jonathan M. Mansbach, Carlos A. Camargo Source Type: journals