Lipidology
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Lp-PLA2 could predict vascular events in elderly
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Lipoprotein-associated phospholipase A2 may be a potential biomarker for vascular events in the elderly, a study suggests. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 21, 2009 Category: Lipidology Source Type: news
Prostate specific antigen levels reduced by statin therapyEmail this article to a colleague.
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Study results show that statin use reduces prostate-specific antigen levels in patients with prostate cancer. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 20, 2009 Category: Lipidology Source Type: news
Dendritic cell ‘vaccine’ could counter atherosclerosisEmail this article to a colleague.
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Vaccination using mature dendritic cells pulsed with oxidized low-density lipoprotein could provide a “powerful” strategy for the immunomodulation of atherosclerosis, claim Dutch researchers. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 20, 2009 Category: Lipidology Source Type: news
Diet induced changes in omega 3 and 6 fatty acids may reduce prostate cancer cell growthEmail this article to a colleague.
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Consumption of a low fat diet leading to reduced omega-6 and increased omega-3 fatty acids is associated with decreased prostate cancer cell growth, according to the results of a US trial. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 19, 2009 Category: Lipidology Source Type: news
LDL cholesterol continues to decrease in USA, but still room for improvementEmail this article to a colleague.
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Study results show that the prevalence of high low-density lipoprotein cholesterol in the USA has decreased significantly since 1999, but use of lipid lowering medications could still be improved. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 19, 2009 Category: Lipidology Source Type: news
Low triglycerides are risk factor for hemorrhagic strokeEmail this article to a colleague.
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Low triglyceride levels are associated with an increased risk for hemorrhagic stroke, particularly in men and those with hypertension or low lipid levels, a large French population-based study has found. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 18, 2009 Category: Lipidology Source Type: news
LDL:HDL cholesterol ratio is marker of early atherosclerosisEmail this article to a colleague.
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The ratio of low-density to high-density lipoprotein cholesterol is associated with the burden of carotid plaque and may thus serve as a marker of early atherosclerosis, Japanese researchers believe. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 18, 2009 Category: Lipidology Source Type: news
Concern about possible adverse lipid effects of high selenium levelsEmail this article to a colleague.
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Individuals with increased levels of plasma selenium have elevated total and non-high-density lipoprotein cholesterol levels, show results published in the Journal of Nutrition. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 17, 2009 Category: Lipidology Source Type: news
Patients with familial dyslipidemia have high levels of ferritinEmail this article to a colleague.
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Patients with familial combined hyperlipidemia or familial hypertriglyceridemia have high levels of ferritin, report researchers. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 17, 2009 Category: Lipidology Source Type: news
Smoking and fatty liver increase risk for the metabolic syndromeEmail this article to a colleague.
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Individuals who smoke and who have fatty liver disease have a significantly increased risk for the metabolic syndrome and its individual components, report investigators. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 16, 2009 Category: Lipidology Source Type: news
Fasting and measurement of triglycerides do not add to CHD risk predictionEmail this article to a colleague.
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Researchers in the UK have shown that estimation of coronary heart disease risk does not benefit from obtaining fasting as opposed to nonfasting lipid measures, and is not significantly influenced by concentration of triglycerides. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 14, 2009 Category: Lipidology Source Type: news
Persistence of an atherogenic lipid profile after treatment of acute infection with brucella [Patient-Oriented and Epidemiological Research]Email this article to a colleague.
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Serum lipid changes during infection may be associated with atherogenesis. No data are available on the effect of Brucellosis on lipids. Lipid parameters were determined in 28 patients with Brucellosis on admission and 4 months following treatment and were compared with 24 matched controls. Fasting levels of total cholesterol (TC), HDL-cholesterol (HDL-C), triglycerides, apolipoproteins (Apo) A, B, E CII, and CIII, and oxidized LDL (oxLDL) were measured. Activities of serum cholesterol ester transfer protein (CETP), paraoxonase 1 (PON1), and lipoprotein-associated phospholipase A2 (Lp-PLA2) and levels of cytokines [interle...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Apostolou, F., Gazi, I. F., Kostoula, A., Tellis, C. C., Tselepis, A. D., Elisaf, M., Liberopoulos, E. N. Tags: Patient-Oriented and Epidemiological Research Source Type: journals
Chronic kidney disease delays VLDL-apoB-100 particle catabolism: potential role of apolipoprotein C-III [Patient-Oriented and Epidemiological Research]Email this article to a colleague.
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To determine the relative contribution of obesity and/or insulin resistance (IR) in the development of dyslipidemia in chronic kidney disease (CKD), we investigated the transport of apolipoprotein (apo) B-100 in nonobese, nondiabetic, nonnephrotic CKD subjects and healthy controls (HC). We determined total VLDL, VLDL1, VLDL2, intermediate density lipoprotein (IDL), and LDL-apoB-100 using intravenous D3-leucine, GC-MS, and multicompartmental modeling. Plasma apoC-III and apoB-48 were immunoassayed. In this case control study, we report higher plasma triglyceride, IDL-, VLDL-, VLDL1-, and VLDL2-apoB-100 concentrations in CKD...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Chan, D. T., Dogra, G. K., Irish, A. B., Ooi, E. M., Barrett, P. H., Chan, D. C., Watts, G. F. Tags: Patient-Oriented and Epidemiological Research Source Type: journals
Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver [Research Articles]Email this article to a colleague.
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In conclusion, our observations implicate that both Es22 and Gus play a role in liver retinoid metabolism. (Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Schreiber, R., Taschler, U., Wolinski, H., Seper, A., Tamegger, S. N., Graf, M., Kohlwein, S. D., Haemmerle, G., Zimmermann, R., Zechner, R., Lass, A. Tags: Research Articles Source Type: journals
A novel role for fatty acid transport protein 1 in the regulation of tricarboxylic acid cycle and mitochondrial function in 3T3-L1 adipocytes [Research Articles]Email this article to a colleague.
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Fatty acid transport proteins (FATPs) are integral membrane acyl-CoA synthetases implicated in adipocyte fatty acid influx and esterification. Whereas some FATP1 translocates to the plasma membrane in response to insulin, the majority of FATP1 remains within intracellular structures and bioinformatic and immunofluorescence analysis of FATP1 suggests the protein primarily resides in the mitochondrion. To evaluate potential roles for FATP1 in mitochondrial metabolism, we used a proteomic approach following immunoprecipitation of endogenous FATP1 from 3T3-L1 adipocytes and identified mitochondrial 2-oxoglutarate dehydrogenase...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Wiczer, B. M., Bernlohr, D. A. Tags: Research Articles Source Type: journals
The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response [Research Articles]Email this article to a colleague.
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Recent studies have shown a link between obesity and endoplasmic reticulum (ER) stress. Perturbations in ER homeostasis cause ER stress and activation of the unfolded protein response (UPR). Adipocyte differentiation contributes to weight gain, and we have shown that markers of ER stress/UPR activation, including GRP78, phospho-eIF2, and spliced XBP1, are upregulated during adipogenesis. Given these findings, the objective of this study was to determine whether attenuation of UPR activation by the chemical chaperone 4-phenylbutyrate (4-PBA) inhibits adipogenesis. Exposure of 3T3-L1 preadipocytes to 4-PBA in the presence of...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Basseri, S., Lhotak, S., Sharma, A. M., Austin, R. C. Tags: Research Articles Source Type: journals
Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum [Research Articles]Email this article to a colleague.
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Human meibum was targetly analyzed for the presence of intact wax esters (WEs) and related compounds by means of reverse-phase HPLC in combination with ion trap mass spectrometry. The major detected WEs were based on C18:n (n = 1–4) unsaturated FAs ranking in the following order of abundance: C18:1>C18:2>C18:3>C18:4. The major fatty alcohols (FAls) found in WE were of saturated nature and varied from C18:0 to C28:0. The three most abundant species were C18:1-FA esters of C24:0, C25:0, and C26:0-FAl. Typically, a major compound based on C18:1-FA and a saturated FAl was accompanied by a few related compounds b...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Butovich, I. A., Wojtowicz, J. C., Molai, M. Tags: Research Articles Source Type: journals
Whole-body synthesis secretion of docosahexaenoic acid from circulating eicosapentaenoic acid in unanesthetized rats [Research Articles]Email this article to a colleague.
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Dietary docosahexaenoic acid (DHA; 22:6n-3) and eicosapentaenoic acid (EPA; 20:5n-3) are considered important for maintaining normal heart and brain function, but little EPA is found in brain, and EPA cannot be elongated to DHA in rat heart due to the absence of elongase-2. Ingested EPA may have to be converted in the liver to DHA for it to be fully effective in brain and heart, but the rate of conversion is not agreed on. This rate was determined in male adult rats fed a standard n-3 PUFA, containing diet by infusing unesterified albumin-bound [U-13C]EPA intravenously for 2 h and measuring esterified [13C]labeled PUFAs in...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Gao, F., Kiesewetter, D., Chang, L., Ma, K., Rapoport, S. I., Igarashi, M. Tags: Research Articles Source Type: journals
Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments [Research Articles]Email this article to a colleague.
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Oxygenation of the 5-lipoxygenase product 5S-hydroxyeicosatetraenoic acid by cyclooxygenase-2 yields a bicyclic di-endoperoxide. The di-endoperoxide contains two peroxides spanning from carbons 9 to 11 and 8 to 12, and two hydroxyls at carbons 5 and 15 of arachidonic acid (Schneider C., et al. 2006. Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2. J. Am. Chem. Soc. 128: 720). Here, we report that treatment of the di-endoperoxide with hematin or ferrous chloride results in cleavage of both peroxide O-O bonds and of the bonds between the carbons that carry the peroxide groups, producing the ...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Griesser, M., Boeglin, W. E., Suzuki, T., Schneider, C. Tags: Research Articles Source Type: journals
Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity [Research Articles]Email this article to a colleague.
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We examined the antioxidant mechanism of a recombinant rat L-FABP in the presence of a hydrophilic (AAPH) or lipophilic (AMVN) free radical generator. Recombinant L-FABP amino acid sequence and its amino acid oxidative products following oxidation were identified by MALDI quadrupole time-of-flight MS after being digested by endoproteinase Glu-C. L-FABP was observed to have better antioxidative activity when free radicals were generated by the hydrophilic generator than by the lipophilic generator. Oxidative modification of L-FABP included up to five methionine oxidative peptide products with a total of ~80 Da mass shift co...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Yan, J., Gong, Y., She, Y.-M., Wang, G., Roberts, M. S., Burczynski, F. J. Tags: Research Articles Source Type: journals
Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key [Research Articles]Email this article to a colleague.
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Pregnenolone (PREG) and dehydroepiandrosterone (DHEA), and their respective sulfated forms PREGS and DHEAS, were among the first steroids to be identified in rodent brain. However, unreliable steroid isolation and solvolysis procedures resulted in errors, particularly in the case of brain steroid sulfates analyzed by radioimmunology or GC-MS of liberated free steroids. By using a solid-phase extraction recycling/elution procedure, allowing the strict separation of sulfated, free, and fatty acid esters of PREG and DHEA, PREGS and DHEAS, unlike free PREG, were not detected in rat and mouse brain and plasma. Conversely, consi...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Liere, P., Pianos, A., Eychenne, B., Cambourg, A., Bodin, K., Griffiths, W., Schumacher, M., Baulieu, E.-E., Sjovall, J. Tags: Research Articles Source Type: journals
GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4 [Research Articles]Email this article to a colleague.
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Glycosylphosphatidylinositol-anchored HDL-binding protein (GPIHBP1) binds both LPL and chylomicrons, suggesting that GPIHBP1 is a platform for LPL-dependent processing of triglyceride (TG)-rich lipoproteins. Here, we investigated whether GPIHBP1 affects LPL activity in the absence and presence of LPL inhibitors angiopoietin-like (ANGPTL)3 and ANGPTL4. Like heparin, GPIHBP1 stabilized but did not activate LPL. ANGPTL4 potently inhibited nonstabilized LPL as well as heparin-stabilized LPL but not GPIHBP1-stabilized LPL. Like ANGPTL4, ANGPTL3 inhibited nonstabilized LPL but not GPIHBP1-stabilized LPL. ANGPTL3 also inhibited h...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Sonnenburg, W. K., Yu, D., Lee, E-C., Xiong, W., Gololobov, G., Key, B., Gay, J., Wilganowski, N., Hu, Y., Zhao, S., Schneider, M., Ding, Z.-M., Zambrowicz, B. P., Landes, G., Powell, D. R., Desai, U. Tags: Research Articles Source Type: journals
Characterization of cis-9 trans-11 trans-15 C18:3 in milk fat by GC and covalent adduct chemical ionization tandem MS [Research Articles]Email this article to a colleague.
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The objective of this work was to identify a new isomer of octatridecenoic acid present in milk fat from ewes fed different sources of -linolenic acid. Structural characterization of this fatty acid was achieved by GC-MS. Analysis of dimethyloxazoline and picolinyl ester derivatives allowed for location of the double bond positions. Covalent adduct chemical ionization tandem mass spectrometry confirmed the positional structure 9-11-15, identical to RLnA, and helped to establish double bond geometry (cis-trans-trans). This new C18:3 isomer could be formed by isomerization of cis-15 bond of RLnA and subsequently converted by...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Gomez-Cortes, P., Tyburczy, C., Brenna, J. T., Juarez, M., de la Fuente, M. A. Tags: Research Articles Source Type: journals
Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size [Research Articles]Email this article to a colleague.
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Increased plasma cholesterol is a known risk factor for cardiovascular disease. Lipoprotein particles transport both cholesterol and triglycerides through the blood. It is thought that the size distribution of these particles codetermines cardiovascular disease risk. New types of measurements can determine the concentration of many lipoprotein size-classes but exactly how each small class relates to disease risk is difficult to clear up. Because relating physiological process status to disease risk seems promising, we propose investigating how lipoprotein production, lipolysis, and uptake processes depend on particle size....
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: van Schalkwijk, D. B., de Graaf, A. A., van Ommen, B., van Bochove, K., Rensen, P. C. N., Havekes, L. M., van de Pas, N. C. A., Hoefsloot, H. C. J., van der Greef, J., Freidig, A. P. Tags: Research Articles Source Type: journals
AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells [Research Articles]Email this article to a colleague.
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In this study, we found that Compound C treatment of MCF7 cells led to Bax redistribution from the cytoplasm to mitochondria and cell death. However, this effect does not involve AMPK. In addition, we found that treatment with this compound leads to an enhanced ceramide production. Analyses by quantitative PCR and ceramide synthase activity assay suggest that ceramide synthase 5 (LASS/CerS 5) is involved in Compound C-induced ceramide upregulation. Downregulation of LASS/CerS 5 was found to attenuate Compound C-mediated ceramide production, Bax redistribution, and cell death. (Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Jin, J., Mullen, T. D., Hou, Q., Bielawski, J., Bielawska, A., Zhang, X., Obeid, L. M., Hannun, Y. A., Hsu, Y.-T. Tags: Research Articles Source Type: journals
Docosahexaenoic acid reduces suppressive and migratory functions of CD4CD25 regulatory T-cells [Research Articles]Email this article to a colleague.
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In this study, we observed that docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, diminished, in a dose-dependent manner, the capacity of Treg cells to inhibit the CD4+CD25– effector T-cell proliferation. DHA not only reduced the migration of Treg cells toward chemokines but also downregulated the mRNA expression of CCR-4 and CXCR-4 in Treg cells. DHA also curtailed ERK1/2 and Akt phosphorylation and downregulated the Smad7 levels in these cells. Contradictorily, DHA upregulated the mRNA expression of Foxp3, CTLA-4, TGF-β, and IL-10; nonetheless, this fatty acid increased the expression of p27KIP1 m...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Yessoufou, A., Ple, A., Moutairou, K., Hichami, A., Khan, N. A. Tags: Research Articles Source Type: journals
15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism [Research Articles]Email this article to a colleague.
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15(S)-lipoxygenase-1 (15-LO-1) was present in the whole-cell homogenate of an acute human monocytic leukemia cell line (THP-1). Additionally, 15-LO-1 was detected on neutral lipid droplets isolated from THP-1 foam cells. To investigate if 15-LO-1 is active on lipid droplets, we used the mouse leukemic monocytic macrophage cell line (RAW 264.7), which are stably transfected with human 15-LO-1. The RAW 15-LO-1 cells were incubated with acetylated low density lipoprotein to generate foam cells. 15(S)-hydroxyeicosatetraenoic acid [15(S)-HETE], the major 15-LO-1 metabolite of arachidonic acid, was produced in the 15-LO-1 RAW bu...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Weibel, G. L., Joshi, M. R., Wei, C., Bates, S. R., Blair, I. A., Rothblat, G. H. Tags: Research Articles Source Type: journals
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse [Research Articles]Email this article to a colleague.
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Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in several cellular functions but most notably cholesterol homeostasis encompassing cholesterol transport, catabolism, and absorption. WAY-252623 (LXR-623) is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR–/– atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. In nonhuman primates with normal lipid levels, WAY-252623 significant...
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Quinet, E. M., Basso, M. D., Halpern, A. R., Yates, D. W., Steffan, R. J., Clerin, V., Resmini, C., Keith, J. C., Berrodin, T. J., Feingold, I., Zhong, W., Hartman, H. B., Evans, M. J., Gardell, S. J., DiBlasio-Smith, E., Mounts, W. M., LaVallie, E. R., W Tags: Research Articles Source Type: journals
Bile acid transporters [Thematic Reviews]Email this article to a colleague.
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This article will review our current understanding of the physiological role and regulation of these important carriers. (Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Dawson, P. A., Lan, T., Rao, A. Tags: Thematic Reviews Source Type: journals
Bringing retinoid metabolism into the 21st century [Commentary]Email this article to a colleague.
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(Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: van Berkel, T. J. C. Tags: Commentary Source Type: journals
Stabilizing lipoprotein lipase [Commentary]Email this article to a colleague.
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(Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Kersten, S., Bensadoun, A. Tags: Commentary Source Type: journals
BMI and adiponectin affect APOE impact on lipid profile of obese childrenEmail this article to a colleague.
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The impact of apolipoprotein E gene variants on lipid profile in obese children and adolescents is affected by body mass index and adiponectin levels, research suggests. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 13, 2009 Category: Lipidology Source Type: news
Determination of enthalpy of formation of methyl and ethyl esters of fatty acids.Email this article to a colleague.
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Biofuels composed by fatty acid methyl esters are widely used as partly substituting fuels for diesel fossil fuels. Additionally, it is expected that the diesel biofuel norms will be extended to ethyl esters produced from bioethanol in the upcoming years. A precise knowledge of the standard enthalpy of formation is necessary for the calculation of some parameters useful for the analysis of the combustion process and emissions of a diesel engine operating with different fuels, such as the heating value, the adiabatic flame temperature or the kinetic mechanisms. However, experimental data for this property are scarce, an...
Source: Chemistry and Physics of Lipids - November 13, 2009 Category: Lipidology Authors: Lapuerta M, Rodríguez-Fernández J, Oliva F Tags: Chem Phys Lipids Source Type: journals
Baseline lipids not predictive for stroke in NOMASEmail this article to a colleague.
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Results from the Northern Manhattan Study show that baseline lipid levels were not associated with incident stroke in a cohort of older individuals without previous myocardial infarction. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 13, 2009 Category: Lipidology Source Type: news
LDL cholesterol and adiponectin levels linked to necrotic core-rich coronary plaqueEmail this article to a colleague.
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High levels of low-density lipoprotein cholesterol and low adiponectin concentration are both associated with necrotic core-rich coronary plaque, show results from an ultrasound imaging study. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 12, 2009 Category: Lipidology Source Type: news
Reconstituted HDL improves platelet function in Type 2 diabeticsEmail this article to a colleague.
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Study results show that reconstituted high-density lipoprotein therapy reduces the hyper-reactivity of platelets of patients with Type 2 diabetes, partly by lowering the cholesterol content of platelet membranes. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 12, 2009 Category: Lipidology Source Type: news
Statins and LXR receptor agonists offer ovarian cancer hopeEmail this article to a colleague.
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Statins and liver X receptor agonists could become an effective adjunct therapy against ovarian cancer, US researchers say. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 12, 2009 Category: Lipidology Source Type: news
Long-term statin use reduces risk for gallstones and cholecystectomyEmail this article to a colleague.
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Individuals who use statins for more than a year have significantly reduced risk for developing gallstones followed by cholecystectomy, report researchers. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 11, 2009 Category: Lipidology Source Type: news
The solubilisation of boar sperm membranes by different detergents - a microscopic, MALDI TOF MS, 31P NMR and PAGE study on membrane lysis, extraction efficiency, lipid and protein compositionEmail this article to a colleague.
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Conclusions:
The boar sperm membranes are solubilised to a different extent by the used detergents. Particularly, the very unique DRMs isolated after Triton X-100 exposure are interesting candidates for further studies regarding the architecture of sperm. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - November 11, 2009 Category: Lipidology Authors: Ulrike JakopBeate FuchsRosmarie SuSZGudrun WibbeltBeate BraunKarin MullerJurgen Schiller Source Type: journals
Men with low cholesterol have reduced risk for high-grade prostate cancerEmail this article to a colleague.
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Study results show that men with low total cholesterol have a reduced risk for high-grade prostate cancer. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 10, 2009 Category: Lipidology Source Type: news
Adiponectin linked to CV risk factors, inflammationEmail this article to a colleague.
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Adiponectin, a recently identified adipocyte-derived protein, is closely correlated with cardiovascular risk factors such as insulin resistance and lipid abnormalities, a study in healthy premenopausal women suggests. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 10, 2009 Category: Lipidology Source Type: news
Effect of tocopherol on surface properties of plastid lipids originating from wheat calli cultivated in cadmium presence.Email this article to a colleague.
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The behaviour of equimolar mixtures of alpha-tocopherol with monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG) and phospholipids (PL) isolated from wheat calli cultured on media with and without cadmium was investigated at the air-water interface by surface pressure-area (pi-A) measurements established using an automated Langmuir-type film balance. It was found that monolayers of all studied compounds were expanded. The additivity rule was not fulfilled and the collapse pressure of mixtures was different from these recorded for pure components. This can be related with the existence of interacti...
Source: Chemistry and Physics of Lipids - November 9, 2009 Category: Lipidology Authors: Gzyl-Malcher B, Zembala M, Filek M Tags: Chem Phys Lipids Source Type: journals
SAA-LDL shows early promise in CV risk-assessmentEmail this article to a colleague.
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A new biomarker, serum amyloid A–low-density lipoprotein, is useful for assessing cardiovascular risk in people with lipid disorders, show Japanese researchers. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 9, 2009 Category: Lipidology Source Type: news
High HDL and total cholesterol linked to reduced cancer riskEmail this article to a colleague.
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Results from a long-term follow-up study show that men with high total and high-density lipoprotein cholesterol levels have a reduced risk for developing cancer compared with those with lower levels. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 9, 2009 Category: Lipidology Source Type: news
Silent PAD predicts adverse outcome in stroke/TIA patientsEmail this article to a colleague.
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The presence of asymptomatic peripheral arterial disease in patients with stroke or transient ischemic attack is a major risk factor for recurrent vascular events, a study indicates. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - November 6, 2009 Category: Lipidology Source Type: news
Oxyfunctionalization of Unactivated C-H Bonds in Triterpenoids with tert-Butylhydroperoxide Catalyzed by meso-5,10,15,20-Tetramesitylporphyrinate Osmium(II) Carbonyl Complex.Email this article to a colleague.
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A system consisting of meso-5,10,15,20-tetramesitylporphyrinate osmium(II) carbonyl complex [Os(TMP)CO] as a precatalyst and tert-butylhydroperoxide (TBHP) as an oxygen donor is shown to be an efficient, regioselective oxidant system for the allylic oxidation, ketonization and hydroxylation of unactivated C-H bonds in a series of the peracetate derivatives of penta- and tetracyclic triterpenoids. Treatment of the substrates with this oxidant system afforded a variety of novel or scarce oxygenated derivatives in one-step. Structures of the isolated components, after chromatographic separation, were determined by spectro...
Source: Chemistry and Physics of Lipids - November 6, 2009 Category: Lipidology Authors: Ogawa S, Wakatsuki Y, Makino M, Fujimoto Y, Yasukawa K, Kikuchi T, Ukiya M, Akihisa T, Iida T Tags: Chem Phys Lipids Source Type: journals
Properties of sesame oil by detailed (1)H and (13)C-NMR assignments before and after ozonation and their correlation with iodine value, peroxide value, and viscosity measurements.Email this article to a colleague.
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Gaseous ozone chemically reacts with unsaturated triglyceride substrates leading to ozonated derivatives with a wide potential applications, ranging from the petrochemical to the pharmaceutical industry. To date, an ultimate understanding of the ozone reactivity during sesame oil ozonation process as well as detailed (1)H and (13)C-NMR assignments are lacking. A practical advantage of NMR is that a single NMR sample measurement can explain many issues, while similar analysis by traditional methods may require several independent and time-consuming measurements. Moreover, significant relationships among NMR spectra and ...
Source: Chemistry and Physics of Lipids - November 6, 2009 Category: Lipidology Authors: Sega A, Zanardi I, Chiasserini L, Gabbrielli A, Bocci V, Travagli V Tags: Chem Phys Lipids Source Type: journals
A high yield procedure for the preparation of arsonolipids (2,3-diacyloxypropylarsonic acids).Email this article to a colleague.
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The crucial step in the preparation of the title arsonolipids starting from the dichloromethane-soluble dithioarsonite CH(2)(OH)CH(OH)CH(2)-As(SPh)(2) is to avoid an internal cyclization during the acylation which protects the primary -OH group from being acylated. This was to a large extent accomplished by using fatty acyl chloride in the presence of the weak base pyridine and controlling the temperature and rate of the acyl chloride addition, giving approximately 70% yields of arsonolipids. The presence of catalytic amounts of 4-dimethylaminopyridine boosted the yields to 82-85%. This yield is a great improvement ove...
Source: Chemistry and Physics of Lipids - November 6, 2009 Category: Lipidology Authors: Ioannou PV, Tsivgoulis GM Tags: Chem Phys Lipids Source Type: journals
Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid.Email this article to a colleague.
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Asymmetrical flow field-flow fractionation (AsFlFFF) / multi-angle light scattering (MALS) was employed for studying filter-extruded liposomes in carrier solutions with different ionic strength and osmolarity. By dilution of preformed liposome suspensions with different media, only the ionic strength in the external free aqueous phase was changed. Under such conditions the liposomes were found to elute at almost identical elution times, which is in contrast to earlier studies. This may be explained by two opposing effects: a) modulation of interparticulate and particle-wall-repulsion effects and b) osmotic stress-induc...
Source: Chemistry and Physics of Lipids - November 6, 2009 Category: Lipidology Authors: Hupfeld S, Moen HH, Ausbacher D, Haas H, Brandl M Tags: Chem Phys Lipids Source Type: journals
The intact muscle lipid composition of bulls:Email this article to a colleague.
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The objective of the study was to investigate whether matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry and (31)P nuclear magnetic resonance (NMR) spectroscopy are useful tools to study the intact lipid composition of beef. For the MALDI-TOF MS and (31)P NMR investigations muscle samples were selected from a feeding experiment with German Simmental bulls fed different diets. Beside the triacylglycrol (TAGs), phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylinositol (PI) species the MALDI-TOF mass spectra of total muscle lipids gave also intense signals of ca...
Source: Chemistry and Physics of Lipids - November 6, 2009 Category: Lipidology Authors: Dannenberger D, Süß R, Teuber K, Fuchs B, Nuernberg K, Schiller J Tags: Chem Phys Lipids Source Type: journals
