Lp(a) predicts carotid stenosis and occlusion, but not carotid plaque area
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Lipoprotein (Lp)(a) is a significant independent predictor for carotid stenosis and occlusion, but not carotid plaque area, report investigators. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - July 5, 2008 Category: Lipidology Source Type: news
Removal of oxldl dramatically improves atherosclerotic prognosis in mice
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Researchers report that removal of oxidized low-density lipoprotein from the circulation of mice almost completely halts atherosclerotic progression compared with controls. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - July 4, 2008 Category: Lipidology Source Type: news
Link between cvd risk and high lp(a) is weakened by hrt
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Researchers report that the previously observed relationship between high lipoprotein (Lp)(a) and increased risk for cardiovascular disease is weakened in women taking hormone replacement therapy. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - July 3, 2008 Category: Lipidology Source Type: news
Low hdl cholesterol increases risk for memory problems in middle age
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Low levels of high-density lipoprotein cholesterol are associated with memory deficit and decline in middle-aged individuals, report investigators in the journal Arteriosclerosis, Thrombosis, and Vascular Biology. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - July 2, 2008 Category: Lipidology Source Type: news
Cetp inhibitor anacetrapib shows initial promise
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The novel cholesteryl ester transfer protein inhibitor anacetrapib successfully increases high-density lipoprotein cholesterol and reduces low-density lipoprotein cholesterol with no apparent adverse side effects, report investigators. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - July 1, 2008 Category: Lipidology Source Type: news
Adverse lipid profile linked to increased carotid imt in obese children
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Researchers report that dyslipidemia but not the metabolic syndrome is associated with increased carotid intima-media thickness in obese children. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 29, 2008 Category: Lipidology Source Type: news
Statin efficacy in aortic stenosis may be disease stage related
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Statin treatment is effective at slowing progression of aortic valve sclerosis and mild but not moderate aortic stenosis, show results from a retrospective analysis. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 29, 2008 Category: Lipidology Source Type: news
Epa supplementation reduces cad events in dyslipidemic individuals
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JELIS study researchers report that eicosapentaenoic acid significantly reduces the incidence of coronary artery disease events in patients with high triglycerides and low levels of high-density lipoprotein cholesterol. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 28, 2008 Category: Lipidology Source Type: news
Atorvastatin 'cost-effective' for reducing diabetic cardiovascular risk
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Atorvastatin treatment is a cost-effective way of preventing cardiovascular disease in patients with Type 2 diabetes according to French financial guidelines, report researchers. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 26, 2008 Category: Lipidology Source Type: news
Lipoprotein binding preference of cd36 is altered by filipin treatment
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The class B scavenger receptor CD36 binds multiple ligands, including oxidized and native lipoprotein species. CD36 and the related receptor SR-B1 have been localized to caveolae, domains that participate in cell signaling, transcytosis, and regulation of cellular cholesterol homeostasis. Previous work has indicated that the ligand preference of CD36 may depend on the cell type in which it is expressed. To determine if the presence or absence of caveolae is the determining factor for lipoprotein preference, we treated CHO-CD36 and C32 cells with filipin. Filipin treatment rapidly increased the binding capacity of CD36 for ...
Source: Lipids in Health and Disease - June 26, 2008 Category: Lipidology Authors: Jianshe Zhang, Wuying Chu and Ian Crandall Source Type: journals
Eicosapentaenoic acid helps reduce stroke recurrence in jelis trial
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Patients who have suffered previous stroke experience reduced recurrence if they are given eicosapentanenoic acid in addition to a statin, report researchers from the JELIS trial. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 25, 2008 Category: Lipidology Source Type: news
Cetp genotypes linked to higher hdl cholesterol and lower coronary risk
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A comprehensive meta-analysis has shown that rare alleles of three common cholesteryl ester transfer protein gene variants are associated with elevated high-density lipoprotein cholesterol and a correspondingly reduced coronary risk. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 24, 2008 Category: Lipidology Source Type: news
Statin-related changes in oxldl biomarkers do not reflect atherosclerotic progression
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Statin-related changes in oxidized low-density lipoprotein biomarker concentrations do not correlate with measures of coronary lumen dimensions or atheroma volume, show study results. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 24, 2008 Category: Lipidology Source Type: news
Acs patients with previous cabg benefit from intensive statin therapy
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Researchers report that acute coronary syndrome patients who have previously undergone coronary artery bypass grafting gain similar benefit from intensive statin therapy as those who have not, despite a generally increased risk for adverse cardiac events. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 23, 2008 Category: Lipidology Source Type: news
Elevated estrogen levels linked to unfavorable lipid profile in men
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Estradiol and estrone elevations in men cause an unfavorable lipid profile at an early age, report investigators in the journal Atherosclerosis. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 23, 2008 Category: Lipidology Source Type: news
Cac score better predictor of cvd events than carotid imt
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Measurement of coronary artery calcium score is a better subclinical predictor of future cardiovascular disease events than carotid intima-media thickness, report scientists. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 23, 2008 Category: Lipidology Source Type: news
Novel pcsk9 variant causal for autosomal dominant hypercholesterolemia
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A newly discovered variant of the gene encoding proprotein convertase subtilisin/kexin type 9 in a Spanish population may directly contribute to autosomal dominant hypercholesterolemia, report researchers in the Journal of Clinical Endocrinology and Metabolism. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 23, 2008 Category: Lipidology Source Type: news
Icd patients have high omega-3 fatty acid levels in blood
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Individuals with implantable cardioverter defibrillators who have high levels of omega-3 fatty acids in their red blood cells have an increased risk for ventricular arrhythmias, report investigators. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 22, 2008 Category: Lipidology Source Type: news
Soy isoflavone genistein inhibits human adipocyte differentiation
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The soy isoflavone genistein inhibits adipogenesis by suppression of adipocyte lipid accumulation, adipocyte-specific genes, and estrogen receptor α and β, show study results. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 22, 2008 Category: Lipidology Source Type: news
Fatty liver disease may be earliest pathogenic event of metabolic syndrome
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Fatty liver disease is independently associated with insulin resistance and may be one of the earliest signs of the metabolic syndrome, report investigators in the journal Metabolism: Clinical and Experimental. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 20, 2008 Category: Lipidology Source Type: news
Obesity has negative effect on chd risk through residual insulin resistance
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Researchers report that adiposity has a residual negative effect on insulin sensitivity, and therefore future cardiovascular risk, in obese individuals treated for coronary heart disease. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 19, 2008 Category: Lipidology Source Type: news
Combined pravastatin and irbesartan reduces oxldl and spla2-iia activity
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Combined treatment with pravastatin and the angiotensin II type 1 receptor blocker irbesartan reduces activity of the coronary event predictor secretory phospholipase A2 type IIA and oxidized low-density lipoprotein in patients with coronary artery disease, research shows. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 19, 2008 Category: Lipidology Source Type: news
Lipid-rich plaque may predict post-stent implantation myocardial injury
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Lipid-rich, large-volume plaques are associated with increased risk for embolic events following coronary artery stent implantation, report researchers. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 18, 2008 Category: Lipidology Source Type: news
Increasing trend for obesity observed in german children and adolescents
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The percentage of German children with a body mass index above the 97th percentile significantly increased between 1999 and 2006, report investigators. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 18, 2008 Category: Lipidology Source Type: news
Infected adipocytes may contribute to chronic inflammation related cvd
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Adipocyte cell infections lead to increased expression of interleukin-6, potentially contributing to the chronic inflammatory state associated with development of cardiovascular disease and Type 2 diabetes, show study results. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 18, 2008 Category: Lipidology Source Type: news
Mutant hmgcr mrna associated with reduced statin response
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Study findings suggest that increased expression of a shortened transcript of the HMGCR gene produces smaller than usual reductions in plasma lipids in response to simvastatin treatment. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 18, 2008 Category: Lipidology Source Type: news
Transcription factor xbp1 needed for normal fatty acid synthesis in the liver
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Researchers report in the journal Science that the transcription factor X-box binding protein 1 plays a role in regulating lipid synthesis in the liver. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 17, 2008 Category: Lipidology Source Type: news
Mitral valve calcification more common with tricuspid than biscuspid aortic valves
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Mitral annular calcification occurs more frequently in individuals with aortic stenosis who have tricuspid as opposed to bicuspid aortic valves, report investigators from the ASTRONOMER study. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 17, 2008 Category: Lipidology Source Type: news
Crp poor predictor cv outcomes after acute coronary syndrome
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The inflammatory marker C-reactive protein does not significantly predict adverse cardiovascular outcomes after hospitalization for acute coronary syndrome, report investigators. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 17, 2008 Category: Lipidology Source Type: news
Human mtdna variants linked to ldl cholesterol level in athletes
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Low-density lipoprotein cholesterol level is associated with mitochondrial DNA haplogroup in athletes, report investigators in the journal Mitochondrion. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 15, 2008 Category: Lipidology Source Type: news
Community initiative brings significant ldl cholesterol reductions
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A closely monitored lipid-lowering initiative by community based physicians resulted in significant improvements in participants' low-density lipoprotein cholesterol levels, show study results. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 15, 2008 Category: Lipidology Source Type: news
Apo b and a-i levels predict ischemic stroke risk in patients with chd
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Levels of pro-atherogenic apolipoprotein B and anti-atherogenic apo A-I independently predict ischemic stroke in patients with coronary heart disease, report investigators in the Journal of the Neurological Sciences. (Source: MedWire News - Lipidology)
Source: MedWire News - Lipidology - June 13, 2008 Category: Lipidology Source Type: news
[commentary] errata. pcsk9 function and physiology
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PCSK9 has exploded onto center stage of plasma cholesterol metabolism, raising hopes for a new strategy to treat hypercholesterolemia. PCSK9 in a plasma protein that triggers increased degradation of the LDL receptor. Gain-of-function mutations in PCSK9 reduce LDL receptor levels in the liver, resulting in high levels of LDL cholesterol in the plasma and increased susceptibility to coronary heart disease. Loss-of-function mutations lead to higher levels of the LDL receptor, lower LDL cholesterol levels, and protection from coronary heart disease. Two papers in this issue of the Journal of Lipid Research exemplify the rapid...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Peterson, A. S., Fong, L. G., Young, S. G. Tags: Commentary Source Type: journals
[calendar] calendar
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(Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Tags: Calendar Source Type: journals
[errata] errata. pcsk9 function and physiology
discuss this article
PCSK9 has exploded onto center stage of plasma cholesterol metabolism, raising hopes for a new strategy to treat hypercholesterolemia. PCSK9 in a plasma protein that triggers increased degradation of the LDL receptor. Gain-of-function mutations in PCSK9 reduce LDL receptor levels in the liver, resulting in high levels of LDL cholesterol in the plasma and increased susceptibility to coronary heart disease. Loss-of-function mutations lead to higher levels of the LDL receptor, lower LDL cholesterol levels, and protection from coronary heart disease. Two papers in this issue of the Journal of Lipid Research exemplify the rapid...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Peterson, A. S., Fong, L. G., Young, S. G. Tags: Errata Source Type: journals
[methods] pancreatic contamination of mesenteric adipose tissue samples can be avoided by adjusted dissection procedures
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Mesenteric adipose tissue, located in the mesenterium of the intestines, is believed to play a central role in the development of obesity-related diseases. We have found that mesenteric fat samples harvested from rodents are frequently of poor quality, exhibiting partly degraded RNA. To investigate the background for this observation, we screened adipose tissue samples from two independent studies on rodents for markers of different tissues and cell types. We found that mesenteric adipose tissue samples of low quality are "contaminated" by pancreatic tissue. To locate the affected area, we dissected the mesenteric fat depo...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Caesar, R., Drevon, C. A. Tags: Methods Source Type: journals
[research articles] evolution of the bile salt nuclear receptor fxr in vertebrates
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Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding these molecules may show adaptive evolutionary changes. We compared across species the bile salt specificity of the major transcriptional regulator of bile salt synthesis, the farnesoid X receptor (FXR). We found that FXRs have changed specificity for primary bile salts across species by altering the shape and size of the ligand binding pocket. In particular, the ligand binding pockets of sea lamprey (Petromyzon marinus) and zebrafish (Danio rerio) FXRs, as predicted by ...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Reschly, E. J., Ai, N., Ekins, S., Welsh, W. J., Hagey, L. R., Hofmann, A. F., Krasowski, M. D. Tags: Research Articles Source Type: journals
[research articles] scavenger receptor class b type i localizes to a late endosomal compartment
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We report that red fluorescent protein-tagged mouse SR-BI (RFP-mSR-BI) colocalizes with the late endosomal and lysosomal markers, Rab7, LBPA, and Rab9. In addition, endogenous SR-BI is also found on lysosomes and colocalizes with LAMP-2 in primary hepatocytes. Furthermore, we demonstrate that the trafficking of SR-BI through these compartments is Rab7 dependent. Interestingly, filipin staining indicates accumulation of lysosomal cholesterol in SR-BI-deficient (–/–) as compared with wild-type hepatocytes. In addition to its role as a plasma membrane receptor, SR-BI may function in cholesterol trafficking from la...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Ahras, M., Naing, T., McPherson, R. Tags: Research Articles Source Type: journals
[research articles] dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
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In this study we quantified CLS in visceral and subcutaneous depots from two strains of genetically obese mice, db/db and ob/ob. In both strains, CLS were prevalent in visceral compared with subcutaneous fat. Adipocyte size and CLS density exhibited a positive correlation both in visceral and in subcutaneous depots; however, the finding that adipocyte size was smallest and CLS density highest in visceral fat suggests a different susceptibility of visceral and subcutaneous adipocytes to death. Visceral fat CLS density was 3.4-fold greater in db/db than in ob/ob animals, which at the age at which our experimental strain was ...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Murano, I., Barbatelli, G., Parisani, V., Latini, C., Muzzonigro, G., Castellucci, M., Cinti, S. Tags: Research Articles Source Type: journals
[research articles] the hepatic uptake of vldl in lrp-ldlr-/-vldlr-/- mice is regulated by lpl activity and involves proteoglycans and sr-bi
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LPL activity plays an important role in preceding the VLDL remnant clearance via the three major apolipoprotein E (apoE)-recognizing receptors: the LDL receptor (LDLr), LDL receptor-related protein (LRP), and VLDL receptor (VLDLr). The aim of this study was to determine whether LPL activity is also important for VLDL remnant clearance irrespective of these receptors and to determine the mechanisms involved in the hepatic remnant uptake. Administration of an adenovirus expressing LPL (AdLPL) into lrp–ldlr–/–vldlr–/– mice reduced both VLDL-triglyceride (TG) and VLDL-total cholesterol (TC) levels...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Hu, L., van der Hoogt, C. C., Espirito Santo, S. M. S., Out, R., Kypreos, K. E., van Vlijmen, B. J. M., Van Berkel, T. J. C., Romijn, J. A., Havekes, L. M., van Dijk, K. W., Rensen, P. C. N. Tags: Research Articles Source Type: journals
[research articles] elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition
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This report examines the impact of elevated Elovl-5 activity on hepatic function. Adenovirus-mediated induction of Elovl5 activity in livers of C57BL/6 mice increased hepatic and plasma levels of dihomo--linolenic acid (20:3,n-6) while suppressing hepatic arachidonic acid (20:4,n-6) and docosahexaenoic acid (22:6,n-3) content. The fasting-refeeding response of peroxisome proliferator-activated receptor -regulated genes was attenuated in mice with elevated Elovl5 activity. In contrast, the fasting-refeeding response of hepatic sterol-regulatory element binding protein-1 (SREBP-1)-regulated and carbohydrate-regulatory elemen...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Wang, Y., Torres-Gonzalez, M., Tripathy, S., Botolin, D., Christian, B., Jump, D. B. Tags: Research Articles Source Type: journals
[research articles] control of cholesteryl ester transfer protein activity by sequestration of lipid transfer inhibitor protein in an inactive complex
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Lipid transfer inhibitor protein (LTIP) is a physiologic regulator of cholesteryl ester transfer protein (CETP) function. We previously reported that LTIP activity is localized to LDL, consistent with its greater inhibitory activity on this lipoprotein. With a recently described immunoassay for LTIP, we investigated whether LTIP mass is similarly distributed. Plasma fractionated by gel filtration chromatography revealed two LTIP protein peaks, one coeluting with LDL, and another of ~470 kDa. The 470 kDa LTIP complex had a density of 1.134 g/ml, indicating ~50% lipid content, and contained apolipoprotein A-I. By mass spectr...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: He, Y., Greene, D. J., Kinter, M., Morton, R. E. Tags: Research Articles Source Type: journals
[research articles] regulation of lipin-1 gene expression by glucocorticoids during adipogenesis
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Lipin-1 deficiency in the mouse causes generalized lipodystrophy, characterized by impaired adipose tissue development and insulin resistance. Lipin-1 expression in differentiating preadipocytes is required for normal expression of adipogenic transcription factors, including peroxisome proliferator-activated receptor and CCAAT enhancer binding protein , and for the synthesis of triacylglycerol. The requirement of lipin-1 for adipocyte differentiation can be explained, in part, by its activity as the sole adipocyte phosphatidic acid phosphatase-1 enzyme, which converts phosphatidate to diacylglycerol, the immediate precurso...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Zhang, P., O'Loughlin, L., Brindley, D. N., Reue, K. Tags: Research Articles Source Type: journals
[research articles] accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves
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The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we investigated whether plant sterols accumulate in aortic valve lesions. Serum samples were collected from 82 patients with severe AS and from 12 control subjects. Aortic valves were obtained from a subpopulation of 21 AS patients undergoing valve surgery and from 10 controls. Serum and valvular total cholesterol and noncholesterol sterols were measured by gas-liquid chromatography. Noncholesterol sterols, including both cholesterol precursor...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Helske, S., Miettinen, T., Gylling, H., Mayranpaa, M., Lommi, J., Turto, H., Werkkala, K., Kupari, M., Kovanen, P. T. Tags: Research Articles Source Type: journals
[research articles] candidate genes for plasma triglyceride, ffa, and glucose revealed from an intercross between inbred mouse strains nzb/b1nj and nzw/lacj
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To identify the genes controlling plasma concentrations of triglycerides (TGs), FFAs, and glucose, we carried out a quantitative trait loci (QTL) analysis of the closely related mouse strains New Zealand Black (NZB/B1NJ) and New Zealand White (NZW/LacJ), which share 63% of their genomes. The NZB x NZW F2 progeny were genotyped and phenotyped to detect QTL, and then comparative genomics, bioinformatics, and sequencing were used to narrow the QTL and reduce the number of candidate genes. Triglyceride concentrations were linked to loci on chromosomes (Chr) 4, 7, 8, 10, and 18. FFA concentrations were affected by a significant...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Su, Z., Tsaih, S.-w., Szatkiewicz, J., Shen, Y., Paigen, B. Tags: Research Articles Source Type: journals
[research articles] alteration of retinal rod outer segment membrane fluidity in a rat model of smith-lemli-opitz syndrome
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Smith-Lemli-Opitz syndrome (SLOS) is caused by an inherited defect in the last step in cholesterol (Chol) biosynthesis, leading to abnormal accumulation of 7-dehydrocholesterol and decreased Chol levels. Progressive retinal degeneration occurs in an animal model of SLOS, induced by treating rats with AY9944, a selective inhibitor of the enzyme affected in SLOS. Here we evaluated alterations in the biochemical and physical properties of retinal rod outer segment (ROS) membranes in this animal model. At 1 month of AY9944 treatment, there were modest alterations in fatty acid composition, but no significant differences in cis...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Boesze-Battaglia, K., Damek-Poprawa, M., Mitchell, D. C., Greeley, L., Brush, R. S., Anderson, R. E., Richards, M. J., Fliesler, S. J. Tags: Research Articles Source Type: journals
[research articles] decreased ipla2{gamma} expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis
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Our previous studies showed that renal proximal tubular cells (RPTC) express Ca2+-independent phospholipase A2 (iPLA2) in endoplasmic reticulum (ER) and mitochondria and that iPLA2 prevents and/or repairs lipid peroxidation induced by oxidative stress. Our present studies determined the importance of iPLA2 in mitochondrial and cell function using an iPLA2-specific small hairpin ribonucleic acid (shRNA) adenovirus. iPLA2 expression and activity were decreased in the ER by 24 h and in the mitochondria by 48 h compared with scrambled shRNA adenovirus-treated cells. Lipid peroxidation was elevated by 2-fold at 24 h and remaine...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Kinsey, G. R., Blum, J. L., Covington, M. D., Cummings, B. S., McHowat, J., Schnellmann, R. G. Tags: Research Articles Source Type: journals
[research articles] characterization of overall ceramide species in human stratum corneum
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Ceramides (CERs) in human stratum corneum (SC) play physicochemical roles in determining barrier and water-holding functions of the skin, and specific species might be closely related to the regulation of keratinization, together with other CER-related lipids. Structures of those diverse CER species, however, have not been comprehensively revealed. The aim of this study was to characterize overall CER species in the SC. First, we constructed 3D multi-mass chromatograms of the overall CER species, based on normal-phase liquid chromatography (NPLC) connected to electrospray ionization-mass spectrometry (ESI-MS) using a gradi...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Masukawa, Y., Narita, H., Shimizu, E., Kondo, N., Sugai, Y., Oba, T., Homma, R., Ishikawa, J., Takagi, Y., Kitahara, T., Takema, Y., Kita, K. Tags: Research Articles Source Type: journals
[research articles] inhibition of stearoyl coa desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster
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Reduction of stearoyl CoA desaturase (SCD) activity has been shown to induce resistance to diet-induced obesity in mice. In the present study, SCD was inhibited by feeding sterculic oil (SO) to male Golden Syrian Hamsters fed high-fat diets with or without added dietary cholesterol. In the absence of cholesterol, SO had little impact on adipose tissue mass or plasma lipoprotein concentrations. When cholesterol was included in the diet, inhibition of SCD resulted in reduced body weight, adipose tissue mass, and feed efficiency. These animals also exhibited a marked hypercholesterolemia, with an accumulation of free-choleste...
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Major, C. A., Ryan, K., Bennett, A. J., Lock, A. L., Bauman, D. E., Salter, A. M. Tags: Research Articles Source Type: journals
[research articles] effects of trans mufa from dairy and industrial sources on muscle mitochondrial function and insulin sensitivity
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In conclusion, dietary trans MUFA of dairy or industrial origin have similar effects and do not impair muscle mitochondrial capacity and insulin sensitivity. (Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - June 13, 2008 Category: Lipidology Authors: Tardy, A.-L., Giraudet, C., Rousset, P., Rigaudiere, J.-P., Laillet, B., Chalancon, S., Salles, J., Loreau, O., Chardigny, J.-M., Morio, B. Tags: Research Articles Source Type: journals
