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Editors for Acta MaterialiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Materialia)
Source: Acta Materialia - March 18, 2010 Category: Materials Science Source Type: journals

Nanoprodrugs of NSAIDs Inhibit the Growth of U87-MG Glioma CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we prepared six nanometer-sized prodrugs (nanoprodrugs) of NSAIDs, ibuprofen, indomethacin, and naproxen through the spontaneous emulsification mechanism using monomeric and dimeric derivatives of the NSAIDs. We evaluated their effect on the proliferation of U87-MG glioma cells by cell counting, WST-1 cell proliferation reagent, and propidium iodide incorporation. The two ibuprofen nanoprodrugs inhibited the cell growth more potently than the indomethacin nanoprodrugs, whereas the naproxen nanoprodrugs did not show any significant effect. Remarkably, ibuprofen did not show any effect at an equimolar concentr...
Source: Journal of Nanomaterials - March 17, 2010 Category: Materials Science Source Type: journals

A High-Yield Synthesis of Chalcopyrite CuInS2 Nanoparticles with Exceptional Size ControlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report high-yield and efficient size-controlled syntheses of Chalcopyrite CuInS2 nanoparticles by decomposing molecular single source precursors (SSPs) via microwave irradiation in the presence of 1,2-ethanedithiol at reaction temperatures as low as 100°C and times as short as 30 minutes. The nanoparticles sizes were 1.8 nm to 10.8 nm as reaction temperatures were varied from 100°C to 200°C with the bandgaps from 2.71 eV to 1.28 eV with good size control and high yields (64%–95%). The resulting nanoparticles were analyzed by XRD, UV-...
Source: Journal of Nanomaterials - March 17, 2010 Category: Materials Science Source Type: journals

Dimensionality reduction of fMRI time series data using locally linear embeddingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion LLE is promising for fMRI data analysis and has potential advantages compared with PCA in terms of its ability to find non-linear relationships. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s10334-010-0204-0Authors Peter Mannfolk, Lund University Department of Medical Radiation Physics, Clinical Sciences Barngatan 2B 22185 Lund SwedenRonnie Wirestam, Lund University Department of Medical Radiation Physics, Clinical Sciences Barngatan 2B 22185 Lund SwedenMarkus Nilsson, Lund University Department of Medical Radiation Physics, Clinical Sciences Barngatan 2B 22185 Lund Swe...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - March 14, 2010 Category: Materials Science Tags: Magnetic Resonance Materials in Physics, Biology and Medicine Source Type: journals

Distribution and fibre field similarity mapping of the human anterior commissure fibres by diffusion tensor imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The anterior commissure may play a more important role in interhemispheric communication than currently presumed by conveying axons from a wider territory, and the fibre field similarity maps give a novel approach to quantifying and visualising characteristics of fibre tracts. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s10334-010-0201-3Authors Markand Dipankumar Patel, King’s College London Division of Imaging Sciences London SE1 7EH UKNicolas Toussaint, King’s College London Division of Imaging Sciences London SE1 7EH UKGeoffrey David Charles-Edwards, King’s C...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - March 14, 2010 Category: Materials Science Tags: Magnetic Resonance Materials in Physics, Biology and Medicine Source Type: journals

MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Flow velocities and wall shear stress were successfully measured in this mouse model of stable and unstable plaque. The presented tools can be used to provide valuable insights in the pathogenesis of atherosclerosis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s10334-010-0200-4Authors Glenda S. van Bochove, Eindhoven University of Technology Biomedical NMR, Department of Biomedical Engineering PO Box 513 5600 MB Eindhoven The NetherlandsRoel Straathof, Eindhoven University of Technology Biomedical NMR, Department of Biomedical Engineering PO Box 513 5600 MB Eindhove...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - March 14, 2010 Category: Materials Science Tags: Magnetic Resonance Materials in Physics, Biology and Medicine Source Type: journals

Prediction of myocardial signal during CINE balanced SSFP imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The proposed signal model produced more accurate predictions of myocardial signal compared to existing models and can be used for the optimization of pulse sequences and protocols. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s10334-010-0202-2Authors Kyunghyun Sung, Stanford University Department of Radiology, Lucas Center for MRI/S 1201 Welch Road Stanford CA 94305-5488 USAHsu-Lei Lee, University of Southern California Ming Hsieh Department of Electrical Engineering Los Angeles CA USAHouchun H. Hu, University of Southern California Ming Hsieh Department of Electrical ...
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - March 14, 2010 Category: Materials Science Tags: Magnetic Resonance Materials in Physics, Biology and Medicine Source Type: journals

Editors for Scripta MaterialiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Scripta Materialia)
Source: Scripta Materialia - March 12, 2010 Category: Materials Science Source Type: journals

SnapShot: Bioreactors systems in tissue engineering (TE) & regenerative medicine (RM).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SnapShot: Bioreactors systems in tissue engineering (TE) & regenerative medicine (RM). Biomaterials. 2010 Apr;31(11):3114-5 Authors: Martin I, Riboldi SA, Jakob M, Wendt D PMID: 20213922 [PubMed - in process] (Source: Biomaterials)
Source: Biomaterials - March 12, 2010 Category: Materials Science Authors: Martin I, Riboldi SA, Jakob M, Wendt D Tags: Biomaterials Source Type: journals

Collagen-embedded hydroxylapatite–beta-tricalcium phosphate–silicon dioxide bone substitute granules assist rapid vascularization and promote cell growthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author(s): Shahram M Ghanaati, Benjamin W Thimm, Ronald E Unger, Carina Orth, Thomas Kohler, Mike Barbeck, Ralph Muller and C James KirkpatrickAffiliation(s): Institute of Pathology, Johannes Gutenberg-University Mainz, Langenbeckstr.1, 55101 Mainz, Germany; Institute for Biomechanics, ETH Zurich, Wolfgang-Pauli-Str.10, 8093 Zurich, Switzerland (Source: Biomedical Materials)
Source: Biomedical Materials - March 8, 2010 Category: Materials Science Source Type: journals

Fibroblastic response and surface characterization of O2-plasma-treated thermoplastic polyetherurethaneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author(s): Henning Schlicht, Havard J Haugen, Roya Sabetrasekh and Erich WintermantelAffiliation(s): Chair of Biomedical Engineering, Technische Universitat Munchen, Garching, Germany; Department for Biomaterials, Faculty of Dentistry, University of Oslo, PO Box 1109 Blindern, 0317 Oslo, Norway (Source: Biomedical Materials)
Source: Biomedical Materials - March 8, 2010 Category: Materials Science Source Type: journals

Polarization of hybridized calcium phosphoaluminosilicates with 45S5-type bioglassesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author(s): Masahiro Kobayashi, Hiroaki Saito, Takatsune Mase, Taketo Sasaki, Wei Wang, Yumi Tanaka, Miho Nakamura, Akiko Nagai and Kimihiro YamashitaAffiliation(s): Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, 2-17-1 sudanuma, Narashino, Chiba 275-0016, Japan; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 anda-Surugadai, Chiyoda, Tokyo 101-0062, Japan (Source: Biomedical Materials)
Source: Biomedical Materials - March 8, 2010 Category: Materials Science Source Type: journals

Preparation, Mechanical, and Thermal Properties of Biodegradable Polyesters/Poly(Lactic Acid) BlendsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Series of biodegradable polyesters poly(butylene adipate) (PBA), poly(butylene succinate) (PBS), and poly(butylene adipate-co-butylene terephthalate) (PBAT) were synthesized successfully by melt polycondensation. The polyesters were characterized by Fourier transform infrared spectroscopy (FTIR), 1H-NMR, differential scanning calorimetry (DSC), and gel permeation chromatography (GPC), respectively. The blends of poly(lactic acid) (PLA) and biodegradable polyester were prepared using a twin screw extruder. PBAT, PBS, or PBA can be homogenously dispersed in PLA matrix at a low content (5–20 wt%), yielding the blend...
Source: Journal of Nanomaterials - March 7, 2010 Category: Materials Science Source Type: journals

The creation of an antithrombotic surface by apyrase immobilization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Blood incompatibility reactions caused by surfaces often involve platelet activation and subsequent platelet-initiated activation of the coagulation and complement cascades. The goal of this study was to immobilize apyrase on a biomaterial surface in order to develop an enzymatically active surface that would have the capacity to inhibit platelet activation by degrading ADP. We were able to immobilize apyrase on a polystyrene surface with preservation of the enzymatic activity. We then analyzed the hemocompatibility of the apyrase surface and of control surfaces by incubation with platelet-rich plasma (PRP) or whole bl...
Source: Biomaterials - March 6, 2010 Category: Materials Science Authors: Nilsson PH, Engberg AE, Bäck J, Faxälv L, Lindahl TL, Nilsson B, Ekdahl KN Tags: Biomaterials Source Type: journals

The cytoskeletal organization of breast carcinoma and fibroblast cells inside three dimensional (3-D) isotropic silicon microstructures.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report differences in adhesion, mechanism of force balance within the cytoskeleton, and deformability among these cell types inside the 3-D microenvironment. HS68 fibroblasts typically stretched and formed vinculin-rich focal adhesions at anchor sites inside the etched cavities. In contrast, MCF10A and MDA-MB-231 cells adopted the curved surfaces of isotropic microstructures and exhibited more diffuse vinculin cytoplasmic staining in addition to vinculin localized in focal adhesions. The measurement of cells elasticity using atomic force microscopy (AFM) indentation revealed that HS68 cells are significantly stiffer (p ...
Source: Biomaterials - March 5, 2010 Category: Materials Science Authors: Nikkhah M, Strobl JS, De Vita R, Agah M Tags: Biomaterials Source Type: journals

The effects of controlled HGF delivery from an affinity-binding alginate biomaterial on angiogenesis and blood perfusion in a hindlimb ischemia model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Enhancing tissue self-repair through the use of active acellular biomaterials is one of the main goals of regenerative medicine. We now describe the features of an injectable alginate biomaterial designed to affinity-bind heparin-binding proteins and release them at a rate reflected by their association constant to alginate-sulfate. The interactions of hepatocyte growth factor (HGF) with alginate-sulfate resulted in factor protection from proteolysis, as shown by mass spectroscopy analysis after trypsin digestion. When the HGF/alginate-sulfate bioconjugate was incorporated into alginate hydrogel, HGF release was sustai...
Source: Biomaterials - March 4, 2010 Category: Materials Science Authors: Ruvinov E, Leor J, Cohen S Tags: Biomaterials Source Type: journals

High-throughput reconstitution of epithelial-mesenchymal interaction in folliculoid microtissues by biomaterial-facilitated self-assembly of dissociated heterotypic adult cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to develop a method for efficient production of folliculoid keratinocyte-dermal papilla (DP) microtissues to facilitate epithelial-mesenchymal interaction. The behavior of DP cells and adult keratinocytes from hairless skin on poly(ethylene-co-vinyl alcohol) (EVAL) surface was investigated. Keratinocytes, poorly adherent both to substrate and between homotypic cells, become suspended disperse cells after homotypic cell seeding. Seeded simultaneously, keratinocytes and DP cells are able to aggregate into spheroidal microtissues. Dynamical analysis shows that DP cells act as a carrier in the pro...
Source: Biomaterials - March 4, 2010 Category: Materials Science Authors: Yen CM, Chan CC, Lin SJ Tags: Biomaterials Source Type: journals

Structure-biocompatibility relationship of dendritic polyglycerol derivatives.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nanocarriers possess advanced physicochemical properties that improve bioavailability, enhance cellular dynamics, and control targetability in drug delivery. In particular, dendritic polyglycerol is a promising new biocompatible scaffold for drug delivery. The present explores the structure-biocompatibility relationship of dendritic polyglycerol (dPG) derivatives possessing neutral, cationic, and anionic charges. The effect of solution pH on the surface charge was studied in buffered aqueous solution between pH 4.8 and 7.4. Surface charge properties of dPG derivatives are discussed in terms of surface functionalities a...
Source: Biomaterials - March 4, 2010 Category: Materials Science Authors: Khandare J, Mohr A, Calderón M, Welker P, Licha K, Haag R Tags: Biomaterials Source Type: journals

Controlled-size embryoid body formation in concave microwell arrays.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Embryonic stem (ES) cells hold great potential as a renewable cell source for regenerative medicine and cell-based therapy. Despite the potential of ES cells, conventional stem cell culture methods do not enable the control of the microenvironment. A number of microscale engineering approaches have been recently developed to control the extracellular microenvironment and to direct embryonic stem cell fate. Here, we used engineered concave microwell arrays to regulate the size and shape of embryoid bodies (EBs)-cell aggregate intermediates derived from ES cells. Murine ES cells were aggregated within concave microwells,...
Source: Biomaterials - March 4, 2010 Category: Materials Science Authors: Choi YY, Chung BG, Lee DH, Khademhosseini A, Kim JH, Lee SH Tags: Biomaterials Source Type: journals

An engineered 3D blood-testis barrier model for the assessment of reproductive toxicity potential.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have developed an in vitro model that replicates the composition, organization, and barrier and spermatogenesis functions of the in vivo rat blood-testis barrier. This engineered blood-testis barrier (eBTB) is based on a three-dimensional (3-D) culture in a bicameral chamber of testicular cells isolated from 18-day-old rats. Peritubular cells were cultured on the bottom of the insert. On the top of the insert, a mixture of Sertoli and germ cells were coated within an artificial extracellular matrix, thereby mimicking the basement membrane. The matrix composition was defined to obtain a cord-like organization. This s...
Source: Biomaterials - March 4, 2010 Category: Materials Science Authors: Audrey L, Froment P, Desmots S, Lecomte A, Habert R, Lemazurier E Tags: Biomaterials Source Type: journals

Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the synergism between shRNAs against Bcl-xL and doxorubicin (DOX) using aptamer-conjugated polyplexes (APs) in combination cancer therapy. Synergistic and selective cancer cell death was achieved by AP-mediated co-delivery of very small amounts of DOX and Bcl-xL-specific shRNA, which simultaneously activated an intrinsic apoptotic pathway. A branched polyethyleneimine (PEI) was grafted to polyethylene glycol (PEI-PEG) to serve as a vehicle for shRNA delivery, and its surface was further conjugated with an anti-PSMA aptamer (APT) for the selective delivery of APs to prostate cancer cells that express pro...
Source: Biomaterials - March 3, 2010 Category: Materials Science Authors: Kim E, Jung Y, Choi H, Yang J, Suh JS, Huh YM, Kim K, Haam S Tags: Biomaterials Source Type: journals

The optimization of porous polymeric scaffolds for chondrocyte/atelocollagen based tissue-engineered cartilage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To broaden the clinical application of cartilage regenerative medicine, we should develop an implant-type tissue-engineered cartilage with firmness and 3-D structure. For that, we attempted to use a porous biodegradable polymer scaffold in the combination with atelocollagen hydrogel, and optimized the structure and composition of porous scaffold. We administered chondrocytes/atelocollagen mixture into the scaffolds with various kinds of porosities (80-95%) and pore sizes (0.3-2.0 mm), consisting of PLLA or related polymers (PDLA, PLA/CL and PLGA), and transplanted the constructs in the subcutaneous areas of nude mice. ...
Source: Biomaterials - March 3, 2010 Category: Materials Science Authors: Tanaka Y, Yamaoka H, Nishizawa S, Nagata S, Ogasawara T, Asawa Y, Fujihara Y, Takato T, Hoshi K Tags: Biomaterials Source Type: journals

The use of injectable forms of fibrin and fibronectin to support axonal ingrowth after spinal cord injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we have therefore examined four biomaterials that can be injected into an injury site and which gel in situ; namely collagen, viscous fibronectin, fibrin, and fibrin + fibronectin (FB/FN). The materials were tested in an experimental knife-cut cavity in the rat spinal cord, and evaluated at 1 week and 4 weeks survival for their biocompatibility, neuroprotective efficacy, and permissiveness for axonal growth. At one week, all four materials showed good integration with the host spinal cord and supported some degree of axonal ingrowth, which was associated with infiltration of Schwann cells and deposition of la...
Source: Biomaterials - March 3, 2010 Category: Materials Science Authors: King VR, Alovskaya A, Wei DY, Brown RA, Priestley JV Tags: Biomaterials Source Type: journals

Phosphatidylserine immobilization of lentivirus for localized gene transfer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Localized and efficient gene transfer can be promoted by exploiting the interaction between the vector and biomaterial. Regulation of the vector-material interaction was investigated by capitalizing on the binding between lentivirus and phosphatidylserine (PS), a component of the plasma membrane. PS was incorporated into microspheres composed of the copolymers of lactide and glycolide (PLG) using an emulsion process. Increasing the weight ratio of PS to PLG led to a greater incorporation of PS. Lentivirus, but not adenovirus, associated with PS-PLG microspheres, and binding was specific to PS relative to PLG alone or P...
Source: Biomaterials - March 3, 2010 Category: Materials Science Authors: Shin S, Tuinstra HM, Salvay DM, Shea LD Tags: Biomaterials Source Type: journals

Editors for Acta MaterialiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Materialia)
Source: Acta Materialia - March 2, 2010 Category: Materials Science Source Type: journals

Corrigendum to “Effect of particles on texture banding in an aluminium alloy” [Scripta Mater. 62 (2010) 78–81]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors apologize for the error in reference 12 on page 4. The correct reference is listed below: [12] O. Engler, in: Proc. of REX’96, 1997, p. 503. (Source: Scripta Materialia)
Source: Scripta Materialia - March 2, 2010 Category: Materials Science Authors: T.A. Bennett, R.H. Petrov, L.A.I. Kestens Source Type: journals

Direct differentiation of human embryonic stem cells into selective neurons on nanoscale ridge/groove pattern arrays.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we present evidence that nanoscale ridge/groove pattern arrays alone can effectively and rapidly induce the differentiation of hESCs into a neuronal lineage without the use any differentiation-inducing agents. Using UV-assisted capillary force lithography, we constructed nanoscale ridge/groove pattern arrays with a dimension and alignment that were finely controlled over a large area. Human embryonic stem cells seeded onto the 350-nm ridge/groove pattern arrays differentiated into neuronal lineage after five days, in the absence differentiation-inducing agents. This nanoscale technique could be used for a ne...
Source: Biomaterials - March 2, 2010 Category: Materials Science Authors: Lee MR, Kwon KW, Jung H, Kim HN, Suh KY, Kim K, Kim KS Tags: Biomaterials Source Type: journals

Poly(ethylene glycol)-grafted poly(propylene fumarate) networks and parabolic dependence of MC3T3 cell behavior on the network composition.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a method to modify poly(propylene fumarate) (PPF), an injectable biomaterial for bone-tissue-engineering applications, by photo-crosslinking it with methoxy poly(ethylene glycol) monoacrylate (mPEGA) at various mPEGA compositions of 0-30%. The bulk properties such as thermal and rheological properties of uncrosslinked mPEGA/PPF blends and the mechanical properties of photo-crosslinked mPEGA/PPF blends were also investigated and correlated with surface characteristics to elaborate on the modulation of mouse MC3T3 cell adhesion, spreading, proliferation and differentiation through controlled physicochemical proper...
Source: Biomaterials - March 2, 2010 Category: Materials Science Authors: Cai L, Wang K, Wang S Tags: Biomaterials Source Type: journals

The Influence of Deposition Conditions on Structural Properties of PbI2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effect of deposition environment conditions on the electrical and structural properties of deposited PbI2 layers were studied. The layers were deposited from solution under dark and room light illumination with and without applying magnetic field. XRD, electrical, and photo-electrical properties were measured at room temperature. An increase in the grain size versus the platelet area was noticed.The electrical properties revealed a dependence on deposition conditions. Dark conductivity increases from 1.7×10−10 to 5×10−9 (Ωcm)-1 when deposition was carried out in darkness. A gain facto...
Source: Texture, Stress, and Microstructure - March 1, 2010 Category: Materials Science Source Type: journals

Simple Synthesis and Growth Mechanism of Core/Shell CdSe/SiOx NanowiresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Core-shell-structured CdSe/SiOx nanowires were synthesized on an equilateral triangle Si (111) substrate through a simple one-step thermal evaporation process. SEM, TEM, and XRD investigations confirmed the core-shell structure; that is, the core zone is single crystalline CdSe and the shell zone is SiOx amorphous layer and CdSe core was grown along (001) direction. Two-stage growth process was present to explain the growth mechanism of the core/shell nanwires. The silicon substrate of designed equilateral triangle providing the silicon source is the key factor to form the core-shell nanowires, which is significant for fab...
Source: Journal of Nanomaterials - March 1, 2010 Category: Materials Science Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The Journal of Pain)
Source: The Journal of Pain - March 1, 2010 Category: Materials Science Tags: Frontmatter Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The Journal of Pain)
Source: The Journal of Pain - March 1, 2010 Category: Materials Science Tags: Frontmatter Source Type: journals

MastheadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The Journal of Pain)
Source: The Journal of Pain - March 1, 2010 Category: Materials Science Tags: Frontmatter Source Type: journals

The Assessment of Pain Quality: An Item Response Theory AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Item Response Theory (IRT) is being increasingly used to develop and evaluate outcome measures. However, many pain measures, including those that assess pain quality, have yet to be evaluated from the IRT perspective. The current study evaluated the scales of a commonly used measure of pain quality (the Pain Quality Assessment Scale, or PQAS) using IRT analyses in 3 samples of patients with chronic pain. The findings indicated variability in the precision of the scales, suggesting that all 3 of the PQAS scales are precise when pain is severe and that the Paroxysmal and Deep scales but not necessarily the Surface ...
Source: The Journal of Pain - March 1, 2010 Category: Materials Science Authors: Clare Waterman, Timothy W. Victor, Mark P. Jensen, Errol M. Gould, Arnold R. Gammaitoni, Bradley S. Galer Tags: Original Reports Source Type: journals

PHBV microspheres - PLGA matrix composite scaffold for bone tissue engineering.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we have established a scaffold by embedding poly (beta-hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV) microspheres into poly (l-lactic-co-glycolic acid) (PLGA) matrix, according to their different solubility in acetone, with the aim of repairing bone defects. PLGA/PHBV scaffolds had good pore parameters, for example, the porosity of PLGA/30% PHBV scaffold can reach to 81.273 +/- 2.192%. Besides, the pore size distribution of the model was evaluated and the results revealed that the pore size mainly distributed between 50 mum and 200 mum. With increasing the amount of PHBV microspheres, the compressive stren...
Source: Biomaterials - March 1, 2010 Category: Materials Science Authors: Huang W, Shi X, Ren L, Du C, Wang Y Tags: Biomaterials Source Type: journals

Decontamination of chemical and biological warfare agents with a single multi-functional material.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the synthesis of new polymers based on a dimethylacrylamide-methacrylate (DMAA-MA) co-polymer backbone that support both chemical and biological agent decontamination. Polyurethanes containing the redox enzymes glucose oxidase and horseradish peroxidase can convert halide ions into active halogens and exert striking bactericidal activity against gram positive and gram negative bacteria. New materials combining those biopolymers with a family of N-alkyl 4-pyridinium aldoxime (4-PAM) halide-acrylate co-polymers offer both nucleophilic activity for the detoxification of organophosphorus nerve agents and internal sou...
Source: Biomaterials - March 1, 2010 Category: Materials Science Authors: Amitai G, Murata H, D Andersen J, R Koepsel R, J Russell A Tags: Biomaterials Source Type: journals

An in vitro regenerated functional human endothelium on a nanofibrous electrospun scaffold.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that this electrospun bi-layer scaffold is a promising candidate for cardiovascular grafting for its capability of promoting the regeneration of a functional endothelium to prevent blood clotting in small diameter grafts. PMID: 20199808 [PubMed - as supplied by publisher] (Source: Biomaterials)
Source: Biomaterials - March 1, 2010 Category: Materials Science Authors: Zhang X, Thomas V, Xu Y, Bellis SL, Vohra YK Tags: Biomaterials Source Type: journals

The role of three-dimensional polymeric scaffold configuration on the uniformity of connective tissue formation by adipose stromal cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, three types of poly(ethyleneglycol-terephthalate)-poly (butylenes terephthalate) (PEGT/PBT) scaffolds [compression molded scaffold (CM), compression molded scaffold after chloroform/isopropanol reticulation (CMR), 3D rapid prototyped fibrous scaffold (RP)] with various configurations were used to support the tissue formation of adipose stromal cells for up to 21 days. Characterization of the scaffolds with muCT revealed that RP scaffolds were composed of repeating structural units with well controlled interconnected pores, in contrast to the irregular pore morphology in CM or CMR. Cell seeding efficacy onto ...
Source: Biomaterials - March 1, 2010 Category: Materials Science Authors: Wang H, van Blitterswijk CA Tags: Biomaterials Source Type: journals

The proliferation and differentiation of placental-derived multipotent cells into smooth muscle cells on fibrillar collagen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Type I collagen constitutes a major portion of the extracellular matrix (ECM) in arterial wall and it is the major substrate for cell growth and differentiation. The goal of this study was to evaluate the differentiation and proliferation of placenta-derived multipotent cells (PDMCs) on polymerized type I collagen fibrils and monomer collagen. PDMCs grown on both polymerized collagen and monomer collagen with transforming growth factor (TGF)-beta treatment increases the expression of smooth muscle cell (SMC)-specific markers, including calponin, alpha-smooth muscle actin (alpha-SMA) and smooth muscle-myosin heavy chain...
Source: Biomaterials - March 1, 2010 Category: Materials Science Authors: Chou MT, Chang SN, Ke C, Chang HI, Sung ML, Kuo HC, Chen CN Tags: Biomaterials Source Type: journals

Thermal and Mechanical Properties of Chitosan/SiO2 Hybrid CompositesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chitosan-silica (CSSi) hybrid films have been fabricated by sol-gel process using tetraethoxysilane (TEOS) as precursor. The structure of the resulting hybrid has been characterized by Fourier transform infrared spectroscopy (FTIR). Fracture surface has been revealed through a field emission-scanning electron microscopy/energy dispersive spectrometer (FE-SEM/EDS) to probe the dispersion degree and the size of SiO2 particle. Study of morphology using a SEM micrograph and the High Resolution Transmission Electron Microscopy (HRTEM) images of the nanocomposite films suggests that the SiO2 nanoparticles are within the range of...
Source: Journal of Nanomaterials - February 28, 2010 Category: Materials Science Source Type: journals

Suppression of Proinflammatory Cytokines in Functionalized Fullerene-Exposed Dermal KeratinocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Initial experiments using differentially functionalized fullerenes, CD-C60, hexa-C60, and tris-C60, suggested a properties dependent effect on cytotoxic and proliferative responses in human skin keratinocytes. In the present study we investigated the cytokine secretion profile of dermal epithelial cells exposed to functionalized fullerenes. Keratinocyte-derived cytokines affect homing and trafficking of normal and malignant epidermal immune as well as nonimmune cells in vivo. These cytokines are critical for regulating activation, proliferation, and differentiation of epidermal cells. Our results indicate that tris-C60 (si...
Source: Journal of Nanomaterials - February 28, 2010 Category: Materials Science Source Type: journals

Editors for Scripta MaterialiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Scripta Materialia)
Source: Scripta Materialia - February 26, 2010 Category: Materials Science Source Type: journals

The effect of micronscale anisotropic cross patterns on fibroblast migration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cell movement on adhesive surfaces is a complicated process based on myriad cell-surface interactions. Although both micron and nanoscale surface topography have been known to be important in understanding cell-materials interactions, typically only simple patterns (e.g., parallel lines or aligned posts) have been used in studying cell morphology, migration, and behavior. This restriction has limited the understanding of the multidirectional aspects of cell-surface response. The present study was performed to investigate cell morphology and motility on micronscale anisotropic cross patterns and parallel line patterns h...
Source: Biomaterials - February 26, 2010 Category: Materials Science Authors: Jeon H, Hidai H, Hwang DJ, Healy KE, Grigoropoulos CP Tags: Biomaterials Source Type: journals

Synthesis, biocompatibility and cell labeling of l-arginine-functional beta-cyclodextrin-modified quantum dot probes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A series of quantum dots (QDs), CdSe, CdSe/CdS and CdSe/ZnSe, coated with l-arginine-modified beta-cyclodextrin (beta-CD-l-Arg) were prepared in a solution of H2O and hexane by ultrasonic method and characterized using PL, UV-vis, TEM, EDX and FTIR techniques. We observed that beta-CD-l-Arg-coated QDs are water-soluble and stable with high colloidal properties in water. Their photophysical properties are similar to those of trioctylphosphine oxide (TOPO)-coated nanocrystals. The quantum yield (QY) of beta-CD-l-Arg/CdSe/ZnSe QDs in water is 68%, which is much higher than those of beta-CD-l-Arg/CdSe/CdS (26%) and beta-CD...
Source: Biomaterials - February 26, 2010 Category: Materials Science Authors: Zhao MX, Xia Q, Feng XD, Zhu XH, Mao ZW, Ji LN, Wang K Tags: Biomaterials Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Biomaterialia)
Source: Acta Biomaterialia - February 25, 2010 Category: Materials Science Source Type: journals

The effect of static magnetic fields and tat peptides on cellular and nuclear uptake of magnetic nanoparticles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Magnetic nanoparticles are widely used in bioapplications such as imaging (MRI), targeted delivery (drugs/genes) and cell transfection (magnetofection). Historically, the impermeable nature of both the plasma and nuclear membranes hinder potential. Researchers combat this by developing techniques to enhance cellular and nuclear uptake. Two current popular methods are using external magnetic fields to remotely control particle direction or functionalising the nanoparticles with a cell penetrating peptide (e.g. tat); both of which facilitate cell entry. This paper compares the success of both methods in terms of nanopart...
Source: Biomaterials - February 25, 2010 Category: Materials Science Authors: Smith CA, Fuente JD, Pelaz B, Furlani EP, Mullin M, Berry CC Tags: Biomaterials Source Type: journals

The pH-dependent association with cancer cells of tunable functionalized lipid vesicles with encapsulated doxorubicin for high cell-kill selectivity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To enable selective cell-kill, we designed functionalized lipid vesicles with pH-triggered heterogeneous membranes and encapsulated doxorubicin that exhibit tunable surface topography. These vesicles "hide" (mask) the targeting ligands from their surface during circulation in the blood, and only progressively "expose" these ligands as they gradually penetrate deeper into the tumor interstitium, where after endocytosis they burst release their contents. The stimulus to activate the binding reactivity is the pH gradient between the blood stream (pH 7.4-7.0) and the increasingly acidic pH inside the tumor interstitium (pH...
Source: Biomaterials - February 25, 2010 Category: Materials Science Authors: Karve S, Bandekar A, Ali MR, Sofou S Tags: Biomaterials Source Type: journals

In vitro and in vivo performance of a dual drug-eluting stent (DDES).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports on a dual drug-eluting stent (DDES) that has an anti-proliferative and an anti-thrombotic in a biodegradable polymer-coated onto a cobalt-chromium stent. The DDES was prepared by spray coating the bare metal stent with a biodegradable polymer loaded with sirolimus and triflusal, to treat against restenosis and thrombosis, respectively. The 2-layered dual-drug coated stent was characterized in vitro for surface properties before and after expansion, as well as for possible delamination by cross-sectioning the stent in vitro. The in vitro anti-platelet behavior of the triflusal-loaded films was investigate...
Source: Biomaterials - February 25, 2010 Category: Materials Science Authors: Huang Y, Venkatraman SS, Boey FY, Lahti EM, Umashankar PR, Mohanty M, Arumugam S, Khanolkar L, Vaishnav S Tags: Biomaterials Source Type: journals

Bonding of maxillofacial silicone elastomers to an acrylic substrateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: To investigate the effect of three different primers on shear and peel bond strengths between three maxillofacial silicone elastomers and an acrylic resin after 360h of accelerated daylight-aging.Materials and methods: Peel and shear-bond strengths of three maxillofacial silicone elastomers (TechSil S25, Cosmesil M511, Cosmesil Z004) to acrylic denture resin bases using three adhesive primers (611, A304, A330-G) were assessed at baseline and after 360h of accelerated artificial light-aging. Data were collected and statistically analyzed by two-way ANOVA, one-way ANOVA, and Bonferroni post hoc tests (α...
Source: Dental Materials - February 24, 2010 Category: Materials Science Authors: Muhanad M. Hatamleh, David C. Watts Source Type: journals

One-year stability of resin–dentin bonds created with a hydrophobic ethanol-wet bonding techniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Dentin bonding performed with hydrophobic resins using ethanol-wet bonding should be less susceptible to degradation but this hypothesis has never been validated.Objectives: This in vitro study evaluated stability of resin–dentin bonds created with an experimental three-step BisGMA/TEGDMA hydrophobic adhesive or a three-step hydrophilic adhesive after one year of accelerated aging in artificial saliva.Methods: Flat surfaces in mid-coronal dentin were obtained from 45 sound human molars and randomly divided into three groups (n=15): an experimental three-step BisGMA/TEGDMA hydrophobic adhesive applied to ethanol...
Source: Dental Materials - February 24, 2010 Category: Materials Science Authors: Fernanda T. Sadek, Carina S. Castellan, Roberto R. Braga, Sui Mai, Leo Tjäderhane, David H. Pashley, Franklin R. Tay Source Type: journals