Influence of subtilisin on the adhesion of a marine bacterium which produces mainly proteins as extracellular polymers
discuss this article
Journal of Applied Microbiology, Volume 0, Issue 0, Page ???, September 2003.
AbstractAims: The nature of exopolymers involved in the adhesion of a marine biofilm-forming bacterium Pseudoalteromonas sp. D41 was investigated to evaluate and understand the antifouling potential of subtilisin.Methods and Results: The exopolymers of ... (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - May 16, 2008 Category: Microbiology Tags: article Source Type: journals
Antibody action after phagocytosis promotes cryptococcus neoformans and cryptococcus gattii macrophage exocytosis with biofilm-like microcolony formation
discuss this article
Cellular Microbiology, Volume 0, Issue 0, Page ???, December 2004.
Summary Antibody-mediated phagocytosis was discovered over a century ago but little is known about antibody effects in phagolysosomes. We explored the consequences of antibody-mediated phagocytosis for two closely related human pathogenic fungal species, ... (Source: Cellular Microbiology)
Source: Cellular Microbiology - May 16, 2008 Category: Microbiology Tags: article Source Type: journals
In the news
discuss this article
In the News
Nature Reviews Microbiology 6, 416 (2008). doi:10.1038/nrmicro1926
New fungicide foundInsects such as Drosophila spp. produce a range of antimicrobial peptides to protect against infection. One of the antimicrobial peptides that is produced by Drosophila spp. is drosomycin, which has been shown to be highly active against filamentous fungi and (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 16, 2008 Category: Microbiology Tags: News and Analysis Source Type: journals
In this issue
discuss this article
Nature Reviews Microbiology 6, 409 (2008). doi:10.1038/nrmicro1925
Bacteria and archaea are able to move both in liquids and on solid surfaces, and the mechanisms that they use to do so have long been a fascination of many microbiologists. On page 466, Ken Jarrell and Mark McBride describe the many different methods (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 16, 2008 Category: Microbiology Tags: In This Issue Source Type: journals
Cellular microbiology: all aboard the cell-wall shuttle
discuss this article
Cellular microbiology: All aboard the cell-wall shuttle
Nature Reviews Microbiology 6, 414 (2008). doi:10.1038/nrmicro1924
Author: Sheilagh Molloy
The coordination of bacterial cell-wall synthesis has been hotly debated for almost 40 years. A recent paper in Molecular Microbiology now sheds new light on this topic by revealing how the cell elongation–division cycle is controlled in Bacillus subtilis.In rod-shaped bacteria, such (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 16, 2008 Category: Microbiology Authors: Sheilagh Molloy Tags: Research Highlight Source Type: journals
Cellular microbiology: virus plays dead
discuss this article
Cellular microbiology: Virus plays dead
Nature Reviews Microbiology 6, 411 (2008). doi:10.1038/nrmicro1923
Author: Arianne Heinrichs
Vaccinia virus is a large, complex, enveloped DNA virus that belongs to the Poxviridae family of viruses, which includes variola, the causative agent of smallpox. The infectious mature virus (MV) form of vaccinia has been shown to bind to actin-containing finger-like protrusions (filopodia) of the (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 16, 2008 Category: Microbiology Authors: Arianne Heinrichs Tags: Research Highlight Source Type: journals
Virtual networking for microbiologists
discuss this article
Nature Reviews Microbiology 6, 410 (2008). doi:10.1038/nrmicro1922
The advent of Web 2.0 applications, which enable information sharing and virtual networking, could revolutionize science. But are microbiologists taking advantage? (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 16, 2008 Category: Microbiology Tags: Editorial Source Type: journals
Immune evasion: overcoming defensins
discuss this article
Immune evasion: Overcoming defensins
Nature Reviews Microbiology 6, 415 (2008). doi:10.1038/nrmicro1921
Author: Asher Mullard
Human cells rely on various antimicrobial peptides, including defensins, to prevent the spread of pathogenic bacteria. For example, defensins can induce chemotaxis of dendritic cells, and expression of defensins correlates with inhibition of bacterial RNA, DNA and protein synthesis, as well as with reduced bacterial (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 16, 2008 Category: Microbiology Authors: Asher Mullard Tags: Research Highlight Source Type: journals
Techniques and applications: a model infection
discuss this article
Techniques and applications: A model infection
Nature Reviews Microbiology 6, 413 (2008). doi:10.1038/nrmicro1920
Author: Sheilagh Molloy
Reporting in a recent issue of PLoS Biology, Andrew Grant and colleagues describe a new method of modelling the within-host spatiotemporal dynamics of an infection with an intracellular bacterial pathogen.Grant et al. chose to study Salmonella enterica serovar Typhimurium (S. (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 16, 2008 Category: Microbiology Authors: Sheilagh Molloy Tags: Research Highlight Source Type: journals
In brief
discuss this article
Nature Reviews Microbiology 6, 412 (2008). doi:10.1038/nrmicro1915
SymbiosisFree-living tubeworm endosymbionts found at deep-sea ventsHarmer, T. L.et al. Appl. Environ. Microbiol.11 Apr 2008 (doi: 10.1128/AEM.02470-07)Bacterial symbionts can be transmitted by vertical (parent to offspring), horizontal (between individuals in the same niche) or environmental (acquisition (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 16, 2008 Category: Microbiology Tags: Research Highlight Source Type: journals
Coordinating assembly of a bacterial macromolecular machine
discuss this article
Hughes
The assembly of large and complex organelles, such as the bacterial flagellum, poses the formidable problem of coupling temporal gene expression to specific stages of the organelle-assembly process. The discovery that levels of the bacterial flagellar regulatory protein FlgM are controlled by its secretion from (Source: Nature Reviews Microbiology)
Source: Nature Reviews Microbiology - May 16, 2008 Category: Microbiology Authors: Fabienne F. V. ChevanceKelly T. Hughes Tags: Review Source Type: journals
Organic nitrogen of tomato waste hydrolysate enhances glucose uptake and lipid accumulation in cunninghamella echinulata
discuss this article
Journal of Applied Microbiology, Volume 0, Issue 0, Page ???, September 2003.
AbstractAims: To investigate the effect of organic nitrogen on lipogenesis during growth of Cunninghamella echinulata on tomato waste hydrolysate (TWH) media.Methods and Results: Cunninghamella echinulata grown on a TWH medium rapidly took up glucose and ... (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - May 16, 2008 Category: Microbiology Tags: article Source Type: journals
The copper-resistant bacterium acu isolated from the rhizosphere of eichhornia crassipes (mart.) increased the endurance of potamogeton crispus l. to copper toxicity
discuss this article
This study aimed to develop endurance to copper stress in Potamogeton crispus L. by inoculation with the anti-copper strain ACU – a novel Enterobacteriaceae bacterium isolated from the rhizosphere of Eichhornia crassipes with high copper-... (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - May 16, 2008 Category: Microbiology Tags: article Source Type: journals
The use of a quantitative real-time polymerase chain reaction assay for identification and enumeration of lactobacillus buchneri in silage
discuss this article
Journal of Applied Microbiology, Volume 0, Issue 0, Page ???, September 2003.
AbstractAims: To detect and quantify Lactobacillus buchneri in plant samples with the aid of polymerase chain reaction (PCR) methods.Methods and Results: DNA from silage samples spiked with different amounts of L. buchneri cells was isolated using a ... (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - May 16, 2008 Category: Microbiology Tags: article Source Type: journals
Specific detection of escherichia coli isolated from water samples using polymerase chain reaction targeting four genes: cytochrome bd complex, lactose permease, β-d-glucuronidase, and β-d-galactosidase
discuss this article
Journal of Applied Microbiology, Volume 0, Issue 0, Page ???, September 2003.
AbstractAims: To develop a PCR-based method for reliable detection of Escherichia coli that enables its differentiation from biochemically and phylogenetically related bacteria.Methods and Results: Using multiplex PCR targeting four genes (cytochrome bd ... (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - May 16, 2008 Category: Microbiology Tags: article Source Type: journals
Towards a one-step enterobacter sakazakii enrichment
discuss this article
Journal of Applied Microbiology, Volume 0, Issue 0, Page ???, September 2003.
AbstractAims: The current international standard method for detection of Enterobacter sakazakii from milk products is by the International Organization for Standardization and the International Dairy Federation documented method, a procedure involving two-... (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - May 16, 2008 Category: Microbiology Tags: article Source Type: journals
Focal adhesion kinase mediates the interferon-γ-inducible gtpase-induced phosphatidylinositol 3-kinase/akt survival pathway and further initiates a positive feedback loop of nf-κb activation
discuss this article
Cellular Microbiology, Volume 0, Issue 0, Page ???, December 2004.
Summary Interferon-γ-inducible GTPase (IGTP) expression is upregulated in coxsackievirus B3 (CVB3)-infected murine heart and inhibits CVB3-induced apoptosis through activation of the PI3 kinase/Akt pathway. However, the mechanism of this pathway ... (Source: Cellular Microbiology)
Source: Cellular Microbiology - May 16, 2008 Category: Microbiology Tags: article Source Type: journals
Disseminated cutaneous and pulmonary abscesses in an injecting drug user caused by a panton-valentine leucocidin-positive, methicillin-susceptible
staphylococcus aureus
strain
discuss this article
Abstract
Staphylococcus aureus is an important pathogen in injecting drug users. We illustrate this with a case of a young female patient who was admitted
with multiple cutaneous and pulmonary abscesses. The causative strain was characterised using diagnostic microarrays. Genes
encoding Panton-Valentine leucocidin (PVL) were detected, mecA was absent. The overall hybridisation profile allowed us to assign this isolate to ST152, being related to an epidemic community-acquired
methicillin-resistant S. aureus (caMRSA) strain from south-eastern Europe. While PVL-positive MRSA has frequently been observed in inj...
Source: European Journal of Clinical Microbiology & Infectious Diseases - May 15, 2008 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals
Methicillin-resistant
staphylococcus aureus
in hospitals in tbilisi, the republic of georgia, are variants of the brazilian clone
discuss this article
Abstract The purpose of this study was to characterise methicillin-resistant Staphylococcus aureus (MRSA) isolates from the Republic of Georgia, part of the former Soviet Union. Thirty-two non-duplicate MRSA isolates were
collected in the period from May 2006 to February 2007. The patient data were analysed and the isolates were characterised
by staphylococcal protein A (spa) typing, staphylococcal chromosome cassette mec (SCCmec) typing, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE) and the detection of Panton-Valentine
leukocidin (PVL) genes. Only two closely related spa types w...
Source: European Journal of Clinical Microbiology & Infectious Diseases - May 15, 2008 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals
Characterization of two heparan sulphate-binding sites in the mycobacterial adhesin hlp
discuss this article
Conclusions:
Our data indicate that Hlp interacts with heparan sulfate through two distinct regions of the protein. Both heparan sulfate-binding regions here defined are preserved in all mycobacterial Hlp homologues that have been sequenced, suggesting important but possibly divergent roles for this surface-exposed protein in both pathogenic and saprophic species. (Source: BMC Microbiology - Latest articles)
Source: BMC Microbiology - Latest articles - May 15, 2008 Category: Microbiology Authors: Michelle I Portugal, Adriane R Todeschini, Cristiana S de Lima, Carlos AM Silva, Ronaldo Mohana-Borges, Tom HM Ottenhoff, Lucia Mendonca-Previato, Jose O Previato and Maria CV Pessolani Source Type: journals
Complete genome sequence of treponema pallidum ssp. pallidum strain ss14 determined with oligonucleotide arrays
discuss this article
Conclusions:
The observed genetic changes do not have influence on the ability of Treponema pallidum to cause syphilitic infection, since both SS14 and Nichols are virulent in rabbit. However, this is the first assessment of the degree of variation between the two syphilis pathogens and paves the way for phylogenetic studies of this fascinating organism. (Source: BMC Microbiology - Latest articles)
Source: BMC Microbiology - Latest articles - May 15, 2008 Category: Microbiology Authors: Petra Matejkova, Michal Strouhal, David Smajs, Steven J. Norris, Timothy Palzkill, Joseph F. Petrosino, Erica Sodergren, Jason E. Norton, Jaz Singh, Todd A. Richmond, Michael N. Molla, Thomas J. Albert and George M. Weinstock Source Type: journals
Resistance to methicillin and other antimicrobials among community-acquired and nosocomial staphylococcus aureus strains in a pediatric teaching hospital in salvador, northeast brazil
discuss this article
Microbial Drug Resistance , Vol. 0, No. 0.
To report the frequency of methicillin-resistant Staphylococcus aureus (MRSA) infection and to compare the antimicrobial resistance patterns between community-acquired (CA) and nosocomial (NI) strains stratified for resistance to methicillin, this ... (Source: Microbial Drug Resistance)
Source: Microbial Drug Resistance - May 14, 2008 Category: Microbiology Tags: article Source Type: journals
Macrolide-resistance mechanisms in streptococcus pneumoniae isolates from chinese children in association with genes of tetm and integrase of conjugative transposons 1545
discuss this article
This study investigated macrolide-resistant Streptococcus pneumoniae carried by Beijing children presenting with respiratory tract infections. Nasopharyngeal S. pneumoniae strains were tested for sensitivity with 15 antibiotics and further analyzed for ... (Source: Microbial Drug Resistance)
Source: Microbial Drug Resistance - May 14, 2008 Category: Microbiology Tags: article Source Type: journals
An endocytic mechanism for haemoglobin-iron acquisition in candida albicans
discuss this article
Molecular Microbiology, Volume 0, Issue 0, Page ???, December 2004.
Summary The fungal pathogen Candida albicans is able to utilize haemin and haemoglobin as iron sources. Haem-iron utilization is facilitated by Rbt5, an extracellular, glycosylphophatidylinositol (GPI)-anchored, haemin- and haemoglobin-binding protein. ... (Source: Molecular Microbiology)
Source: Molecular Microbiology - May 14, 2008 Category: Microbiology Tags: article Source Type: journals
Looking inside the box: bacterial transistor arrays
discuss this article
Molecular Microbiology, Volume 0, Issue 0, Page ???, December 2004.
Summary One often compares cells to computers, and signalling proteins to transistors. Location and wiring of those molecular transistors is paramount in defining the function of the subcellular chips. The bacterial chemotactic sensing apparatus is a ... (Source: Molecular Microbiology)
Source: Molecular Microbiology - May 14, 2008 Category: Microbiology Tags: article Source Type: journals
Ehmlbp is an essential constituent of the entamoeba histolytica epigenetic machinery and a potential drug target
discuss this article
Molecular Microbiology, Volume 0, Issue 0, Page ???, December 2004.
Summary EhMLBP has been identified as a protein that specifically binds to methylated long interspersed element (LINE) retrotransposons and rDNA in Entamoeba histolytica. EhMLBP is unique to Entamoeba parasites, which makes this protein a possible drug ... (Source: Molecular Microbiology)
Source: Molecular Microbiology - May 14, 2008 Category: Microbiology Tags: article Source Type: journals
Diversity of vibrios associated with reared clams in galicia (nw spain).
discuss this article
Diversity of Vibrios associated with reared clams in Galicia (NW Spain).
Syst Appl Microbiol. 2008 May 14;
Authors: Beaz Hidalgo R, Cleenwerck I, Balboa S, De Wachter M, Thompson FL, Swings J, De Vos P, Romalde JL
The aim of the present study was to characterize and identify vibrios isolated from cultured clams in Galicia (NW Spain). A total of 759 isolates were obtained, phenotypically characterized, grouped and assigned to the genus Vibrio. Subsequently, the genomic diversity of 145 representative strains was analyzed by means of amplified fragment length polymorphism (AFLP), which revealed a high genetic div...
Source: Systematic and Applied Microbiology - May 14, 2008 Category: Microbiology Authors: Beaz Hidalgo R, Cleenwerck I, Balboa S, De Wachter M, Thompson FL, Swings J, De Vos P, Romalde JL Tags: Syst Appl Microbiol Source Type: journals
Comment on: unexpected antimicrobial effect of statins
discuss this article
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Nalin, D. R. Tags: Letter to the Editor Source Type: journals
A review of vancomycin therapeutic drug monitoring recommendations in scotland
discuss this article
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Helgason, K. O., Thomson, A. H., Ferguson, C. Tags: Research letters Source Type: journals
Severe hypokalaemia caused by flucloxacillin
discuss this article
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Hoorn, E. J., Zietse, R. Tags: Research letters Source Type: journals
Daptomycin resistance in enterococcus faecalis prosthetic valve endocarditis
discuss this article
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Hidron, A. I., Schuetz, A. N., Nolte, F. S., Gould, C. V., Osborn, M. K. Tags: Research letters Source Type: journals
High prevalence of ctx-m-15-producing klebsiella pneumoniae among inpatients and outpatients with urinary tract infection in southern india
discuss this article
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Muzaheed, , Doi, Y., Adams-Haduch, J. M., Endimiani, A., Sidjabat, H. E., Gaddad, S. M., Paterson, D. L. Tags: Research letters Source Type: journals
Multidrug-resistant providencia stuartii expressing extended-spectrum {beta}-lactamase per-1, originating in kosovo
discuss this article
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Poirel, L., Bruderer, T., Frei, R., Bernabeu, S., Graber, P., Nordmann, P. Tags: Research letters Source Type: journals
Reduced susceptibility to tetracyclines is associated in vitro with the presence of 16s rrna mutations in mycoplasma hominis and mycoplasma pneumoniae
discuss this article
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Degrange, S., Renaudin, H., Charron, A., Pereyre, S., Bebear, C., Bebear, C. M. Tags: Research letters Source Type: journals
Evidence for chromosomal and plasmid location of cmy-2 cephalosporinase gene in salmonella serotype typhimurium
discuss this article
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Zioga, A., Whichard, J. M., Joyce, K. J., Tzelepi, E., Tzouvelekis, L. S., Miriagou, V. Tags: Research letters Source Type: journals
Design of a 'day 3 bundle' to improve the reassessment of inpatient empirical antibiotic prescriptions
discuss this article
Conclusions
Our measures of care are suitable for the reassessment of empirical inpatient antibiotic prescriptions, with good inter-rater reliability. This quality intervention should be part of a more comprehensive and multifaceted plan to improve antibiotic use in hospitals. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Pulcini, C., Defres, S., Aggarwal, I., Nathwani, D., Davey, P. Tags: Original research Source Type: journals
Gram-negative bacteraemia in non-icu patients: factors associated with inadequate antibiotic therapy and impact on outcomes
discuss this article
Conclusions
Nearly one-third of the non-ICU patients with Gram-negative bacteraemia received inadequate empirical antibiotic therapy. There was no difference in adverse outcomes between patients receiving inadequate or adequate therapy in this study. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Marschall, J., Agniel, D., Fraser, V. J., Doherty, J., Warren, D. K. Tags: Original research Source Type: journals
Ampicillin/sulbactam compared with polymyxins for the treatment of infections caused by carbapenem-resistant acinetobacter spp.
discuss this article
Conclusions
This is the first study comparing current therapeutic options for infections due to carbapenem-resistant Acinetobacter. The most important finding of the present study is that ampicillin/sulbactam appears to be more efficacious than polymyxins, which was an independent factor associated with mortality during treatment. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Oliveira, M. S., Prado, G. V. B., Costa, S. F., Grinbaum, R. S., Levin, A. S. Tags: Original research Source Type: journals
Clinically validated mutation scores for hiv-1 resistance to fosamprenavir/ritonavir
discuss this article
Conclusions
These clinically validated mutation scores should be of interest for the clinical management of PI-experienced patients. The fosamprenavir/ritonavir score A was introduced in the 2006 ANRS algorithm along with isolated mutations I50V and V32I + I47V. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Masquelier, B., Assoumou, K. L., Descamps, D., Bocket, L., Cottalorda, J., Ruffault, A., Marcelin, A. G., Morand-Joubert, L., Tamalet, C., Charpentier, C., Peytavin, G., Antoun, Z., Brun-Vezinet, F., Costagliola, D., on behalf of the ANRS Resistance Study Tags: Original research Source Type: journals
Long-term (4 years) efficacy of lopinavir/ritonavir monotherapy for maintenance of hiv suppression
discuss this article
Conclusions
Our data support the long-term efficacy and safety of lopinavir/ritonavir monotherapy for the maintenance of HIV suppression, a finding that must be confirmed in larger studies. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Pulido, F., Delgado, R., Perez-Valero, I., Gonzalez-Garcia, J., Miralles, P., Arranz, A., Hernando, A., Arribas, J. R. Tags: Original research Source Type: journals
First-line antiretroviral therapy with efavirenz or lopinavir/ritonavir plus two nucleoside analogues: the suska study, a non-randomized comparison from the vach cohort
discuss this article
Conclusions
Our study suggests similar virological efficacy for efavirenz- or lopinavir/ritonavir-based first-line antiretroviral regimens, but an increased risk of discontinuation because of toxicity in case of lopinavir/ritonavir-based therapy. Immunological outcome appeared similar with both regimens. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Domingo, P., Suarez-Lozano, I., Torres, F., Teira, R., Lopez-Aldeguer, J., Vidal, F., Munoz, A., Viciana, P., Lozano, F., Vergara, A., Roca, B., Garcia Alcalde, M. L., Cosin, J., Terron, A., Galindo, M. J., Geijo, P., Ribera, E., Gonzalez, J., Sanchez, T. Tags: Original research Source Type: journals
Absence of hiv-1 shedding in male genital tract after 1 year of first-line lopinavir/ritonavir alone or in combination with zidovudine/lamivudine
discuss this article
Conclusions
No local viral production was evident in semen, despite the local absence of therapeutic antiretroviral drug concentrations in the five patients receiving lopinavir/ritonavir alone. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Ghosn, J., Chaix, M.-L., Peytavin, G., Bresson, J.-L., Galimand, J., Girard, P.-M., Raffi, F., Cohen-Codar, I., Delfraissy, J.-F., Rouzioux, C. Tags: Original research Source Type: journals
Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine--a staccato trial substudy
discuss this article
Conclusions
After the nucleoside reverse transcriptase inhibitor switch, reversal of mitochondrial toxicity was consistent with switch studies of mainly Caucasian patients, although the peripheral mononuclear cell mitochondrial DNA rise exceeded previous reports. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Ananworanich, J., Nuesch, R., Cote, H. C. F., Kerr, S. J., Hill, A., Jupimai, T., Laopraynak, N., Saenawat, S., Ruxrungtham, K., Hirschel, B. Tags: Original research Source Type: journals
Antiviral efficacy, tolerability and pharmacokinetics of efavirenz in an unselected cohort of hiv-infected children
discuss this article
Conclusions
Efavirenz as part of highly active antiretroviral therapy was highly effective in children able to tolerate the drug. Therapeutic drug monitoring (TDM) as part of toxicity management may prevent discontinuation in a subset of patients. Temporal non-adherence occurs frequently. TDM may allow initiation of adherence interventions before viral load becomes detectable. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Wintergerst, U., Hoffmann, F., Jansson, A., Notheis, G., Huss, K., Kurowski, M., Burger, D. Tags: Original research Source Type: journals
Disposition of valganciclovir during continuous renal replacement therapy in two lung transplant recipients
discuss this article
Conclusions
A valganciclovir dosage of 450 mg every 48 h appears adequate for patients under CRRT requiring prophylaxis for CMV infection, providing concentration levels in the range reported for 900 mg once daily dosing outside renal failure. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Perrottet, N., Robatel, C., Meylan, P., Pascual, M., Venetz, J. P., Aubert, J. D., Berger, M. M., Decosterd, L. A., Buclin, T. Tags: Original research Source Type: journals
Pharmacokinetics of moxifloxacin in non-inflamed cerebrospinal fluid of humans: implication for a bactericidal effect
discuss this article
Conclusions
Single oral intake of 400 mg moxifloxacin is accompanied by good penetration through healthy meninges within 2–6 h post-dose and reached adequately high levels in human CSF exerting satisfactory bactericidal activity against penicillin-resistant S. pneumoniae. These results render novel perspectives for a role of moxifloxacin in CNS infections. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Kanellakopoulou, K., Pagoulatou, A., Stroumpoulis, K., Vafiadou, M., Kranidioti, H., Giamarellou, H., Giamarellos-Bourboulis, E. J. Tags: Original research Source Type: journals
Persistence of pcr-positive tissue in benznidazole-treated mice with negative blood parasitological and serological tests in dual infections with trypanosoma cruzi stocks from different genotypes
discuss this article
Conclusions
Our results confirm that NSC-FC-ALTA and blood PCR are the most suitable methods to early detect therapeutic failure in acute murine T. cruzi infection. Additionally, our data show that BC positivity is highly dependent upon the T. cruzi genotype combination. Moreover, our findings demonstrated that PCR tests performed on tissues from animals considered cured after benznidazole treatment still detected T. cruzi DNA, most probably indicating residual infection. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Martins, H. R., Figueiredo, L. M., Valamiel-Silva, J. C. O., Carneiro, C. M., Machado-Coelho, G. L. L., Vitelli-Avelar, D. M., Bahia, M. T., Martins-Filho, O. A., Macedo, A. M., Lana, M. Tags: Original research Source Type: journals
High rate of resistance to locally used antibiotics among enteric bacteria from children in northern ghana
discuss this article
Conclusions
Enteric bacteria from children in urban Northern Ghana are highly resistant to antibiotics used in that area. Therefore, new antibiotics should be introduced for the treatment of infections caused by these bacteria. Additionally, the establishment of a surveillance of the prevalence of the main bacterial infectious agents and their antimicrobial resistance is desirable. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Djie-Maletz, A., Reither, K., Danour, S., Anyidoho, L., Saad, E., Danikuu, F., Ziniel, P., Weitzel, T., Wagner, J., Bienzle, U., Stark, K., Seidu-Korkor, A., Mockenhaupt, F. P., Ignatius, R. Tags: Original research Source Type: journals
In vitro activity of conventional antifungal drugs and natural essences against the yeast-like alga prototheca
discuss this article
Conclusions
Difficulties in treating animals with conventional drugs and the potent in vitro activity of essential oils demonstrated here raise the interest in further investigations on the therapeutic use of these non-conventional natural products. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Tortorano, A. M., Prigitano, A., Dho, G., Piccinini, R., Dapra, V., Viviani, M. A. Tags: Original research Source Type: journals
Post-antifungal effect of amphotericin b and voriconazole against germinated aspergillus fumigatus conidia
discuss this article
Conclusions
An automated method is presented for the determination of PAFE on filamentous fungi using quantifiable numbers of germinated conidia. In contrast to previous results obtained from conidia, this method could demonstrate a PAFE of amphotericin B on Aspergillus that shared characteristics similar to that on Candida spp. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2008 Category: Microbiology Authors: Chryssanthou, E., Loebig, A., Sjolin, J. Tags: Original research Source Type: journals
