MicrobiologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory.

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30

Microbiological investigation of a hospital outbreak of invasive group A streptococcal disease in Krakow, PolandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect The present study reports the epidemiological investigations undertaken in one of Krakow's city hospitals regarding the source of infection and the routes of transmission of a group A streptococcus (Streptococcus pyogenes), using fluorescent in situ hybridization as a rapid method for detecting S. pyogenes carriage in the medical personnel involved. Four patients from the gynaecology department and two patients from the surgery department presented with clinical signs of infection. Characteristics of the S. pyogenes strains isolated from patients and from one medical staff member, including the emm ge...
Source: Clinical Microbiology and Infection - March 13, 2010 Category: Microbiology Authors: M. Strus, A. Drzewiecki, A. Chmielarczyk, A. Tomusiak, P. Romanek, K. Kosowski, P. Kochan, M. van der Linden, R. Lütticken, P. B. Heczko Source Type: journals

Identification of native Bacillus thuringiensis strain from South India having specific cytocidal activity against cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our observations imply that B. thuringiensis LDC-391 is different from the already reported parasporin producers, as it is showing variation in the target specificity.Significance and Impact of the Study: Characterizing these proteins can pave the way to alleviate problems associated with neoplastic transformation and cancer progression. (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - March 13, 2010 Category: Microbiology Authors: K. Poornima, P. Selvanayagam, R. Shenbagarathai Source Type: journals

Erratum to “Resolution of persistent Pediococcus bacteremia with daptomycin treatment: case report and review of the literature” [Diagn Microbiol Infect Dis 66 (2010) 111–115]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The acknowledgement section was inadvertently omitted from the article. The author and Mary-Ellen Marx, Senior Manager, Medical Education at PharmaWrite and her colleagues sincerely regret the error. Acknowledgements should have read as follows: (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Byungse Suh Tags: Erratum Source Type: journals

The epidemiology of recurrent Gram-negative bacteremia in a tertiary-care hospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined recurrent Gram-negative bacteremia in a prospective cohort from a tertiary hospital. Seventeen (7.1%) of 241 bacteremic patients developed recurrence (median time to recurrence = 44 days; range, 9–217 days). Recurrent and nonrecurrent bacteremic patients did not differ in clinical characteristics and mortality. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Jonas Marschall, Joshua Doherty, David K. Warren Tags: Notes Source Type: journals

Vibrio parahaemolyticus-associated gastroenteritis in Italy: persistent occurrence of O3:K6 pandemic clone and emergence of O1:KUT serotypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report 2 cases of O3:K6 and O1:KUT Vibrio parahaemolyticus gastroenteritis associated with consumption of local mussels in Italy in 2008. Serotypic, antibiogram, toxigenic, and pulsed-field gel electrophoresis patterns of these strains were compared to those of other isolates collected from local clinical and seafood samples in 2007 to 2008. We underline the recurrent presence of O3:K6 pandemic clone and the emergence of trh-positive O1:KUT serotype in Italy. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Donatella Ottaviani, Francesca Leoni, Elena Rocchegiani, Cristina Canonico, Stefano Potenziani, Sabrina Santarelli, Laura Masini, Stefania Scuota, Antonio Carraturo Tags: Notes Source Type: journals

Demonstration and utility of clustered pseudohyphae on Gram-stained smears from Candida albicans-positive blood culturesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The presence of clustered and branched pseudohyphae was investigated on Gram-stained smears of 78 consecutive yeast-positive blood cultures. The accuracy of the method was 96.1%, with a positive predictive value of 96.6% for Candida albicans. These findings demonstrate that the presence of clustered and branched pseudohyphae on Gram stain may be used for the rapid and presumptive identification of C. albicans from yeast-positive blood culture bottles. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Mehmet Doymaz, Carmen Yampierre, Georgio Tarchini, William Riley Tags: Notes Source Type: journals

Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas cityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum β-lactamase or AmpC β-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC β-lactamase, 1 Escherichia coli expressed plasmid-mediated AmpC β-lactamase, and 1 E. cloacae produced a carbapenemase. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Jason W. Bennett, Katrin Mende, Monica L. Herrera, Xin Yu, James S. Lewis, Brian L. Wickes, James H. Jorgensen, Clinton K. Murray Tags: Notes Source Type: journals

Efficacy of vancomycin and daptomycin against Staphylococcus aureus isolates collected over 29 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We investigated vancomycin and daptomycin efficacy for Staphylococcus aureus isolates at our institution by testing 221 methicillin-sensitive and 299 methicillin-resistant isolates recovered from serious infections between 1979 and 2007 using a microdilution method. The MIC90's for vancomycin remained constant at 2 μg/mL for methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA). For MSSA, the geometric mean vancomycin MICs remained at 1.1 μg/mL but varied from 1.1 to 1.7 for MRSA. Tolerance to vancomycin was seen in 6.5% of MRSA and 10.5% of MSSA. Daptomycin MIC90's remained at ≤1 ...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Maria D. Appleman, Diane M. Citron Tags: Notes Source Type: journals

An enhanced method for the identification of Leishmania spp. using real-time polymerase chain reaction and sequence analysis of the 7SL RNA gene regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The accurate identification of Leishmania spp. is important for the treatment of infected patients. Molecular methods offer an alternative to time-consuming traditional laboratory techniques for species determination. We redesigned a 7SL RNA gene-based polymerase chain reaction and sequence assay for increased species identification. DNA extracted from 17 reference strains and 10 cultured clinical isolates was examined. Sequence comparison was used successfully to identify organisms to the complex level with intercomplex similarity ranging from 77.5% to 98.4%. Many species within each complex were discriminated a...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Lindsay G. Stevenson, Daniel P. Fedorko, Adrian M. Zelazny Tags: Notes Source Type: journals

Plasmid-mediated quinolone resistance determinants qnr and aac(6′)-Ib-cr in Escherichia coli and Klebsiella spp. from Norway and SwedenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The prevalence of the plasmid-mediated quinolone resistance genes qnr and aac(6′)-Ib-cr was investigated among clinical isolates of Escherichia coli and Klebsiella spp. selected from 2 collections of consecutive isolates collected in 2004 to 2005 in Norway (n = 2479) and Sweden (n = 2980) and 1 group of extended-spectrum β-lactamase (ESBL)-producing isolates collected in 2003 in Norway (n = 71). A total of 414 isolates was selected for screening based on resistance to nalidixic acid and/or reduced susceptibility/resistance to ciprofloxacin. The prevalence of both qnr and aac(6′)-Ib-cr was higher among the ES...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Nabil Karah, Laurent Poirel, Stina Bengtsson, Martin Sundqvist, Gunnar Kahlmeter, Patrice Nordmann, Arnfinn Sundsfjord, Ørjan Samuelsen, the Norwegian Study Group on PMQR Tags: Antimicrobial Susceptibility Studies Source Type: journals

Molecular characterization of moxifloxacin resistance from Canadian Clostridium difficile clinical isolatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Fluoroquinolone resistance in Clostridium difficile has been implicated in recent outbreaks of C. difficile infection. The purpose of this report was to characterize the molecular mechanism conferring resistance to moxifloxacin among C. difficile clinical isolates. Eighty-four C. difficile clinical isolates (collected as part of the Canadian Nosocomial Infection Surveillance Program) were evaluated in the current study. Pulsed-field gel electrophoresis was used to type the isolates. Susceptibility testing was performed using Clinical and Laboratory Standards Institute agar dilution methods. The quinolone resistan...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Andrew Walkty, David A. Boyd, Denise Gravel, Jim Hutchinson, Allison McGeer, Dorothy Moore, Andrew Simor, Kathryn Suh, Geoff Taylor, Mark Miller, Michael R. Mulvey, the Canadian Nosocomial Infection Surveillance Program Tags: Antimicrobial Susceptibility Studies Source Type: journals

In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for diabetic foot infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The in vitro activity of tigecycline and comparative antimicrobial agents was evaluated against 1828 primary baseline pathogens isolated from 844 patients enrolled in the phase 3 clinical trials investigating the efficacy of tigecycline in diabetic foot infection (DFI). The trials were global, enrolling patients in 30 countries. Tigecycline was active against the most prevalent pathogens in DFI, including Gram-positive and Gram-negative isolates of both aerobic and anaerobic bacteria with 95% of MICs ≤2 μg/mL for the entire collection. The spectrum of activity of tigecycline included important pathogens for DF...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Peter J. Petersen, Alexey Ruzin, Margareta Tuckman, C. Hal Jones Tags: Antimicrobial Susceptibility Studies Source Type: journals

Identification of CTX-M β-lactamases in Escherichia coli from hospitalized patients and residents of long-term care facilitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Bacteria harboring CTX-M extended-spectrum β-lactamases (ESBLs) have been identified worldwide, with most reports coming from regions outside North America. We have identified CTX-M enzymes in 31% of ESBL-positive Escherichia coli isolates from our hospital and more than half (53%) of the isolates from associated long-term care facilities. Approximately 3/4 of all CTX-M–bearing isolates were from urine specimens, with a predominance of CTX-M-15. A large proportion of such isolates were nonsusceptible to levofloxacin, trimethoprim/sulfamethoxazole, and all β-lactam antimicrobials with the exception of the carb...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Carl Urban, Noriel Mariano, Patricia A. Bradford, Margareta Tuckman, Sorana Segal-Maurer, Wehbeh Wehbeh, Louise Grenner, Rita Colon-Urban, Brian Johnston, James R. Johnson, James J. Rahal Tags: Antimicrobial Susceptibility Studies Source Type: journals

Chlamydia pneumoniae IgG and IgA antibody titers and prognosis in patients with coronary heart disease: results from the CLARICOR trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The association observed between coronary heart disease (CHD) and Chlamydia (Chlamydophila) pneumoniae antibodies prompted, during the 1990s, several primary and secondary prevention trials with various antibiotics. In our CLARICOR trial, a randomized placebo-controlled trial in 4372 patients with stable CHD, a brief clarithromycin regimen was followed, unexpectedly, by increased long-term mortality. We now compare C. pneumoniae antibody levels at entry with population levels, with the patients' individual histories, and with their subsequent outcomes. IgG antibody levels were somewhat raised, but elevated IgA an...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Jørgen Hilden, Inga Lind, Hans Jørn Kolmos, Bodil Als-Nielsen, Morten Damgaard, Jørgen Fischer Hansen, Stig Hansen, Olav H. Helø, Per Hildebrandt, Gorm Boje Jensen, Jens Kastrup, Erik Kjøller, Henrik Nielsen, Lars Petersen, Christian M. Jespersen, Ch Tags: Clinical Trial Source Type: journals

Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the antifungal susceptibility to fluconazole, itraconazole, and voriconazole of 73 clinical isolates of Candida albicans. Screening for amino acid substitutions in Erg11 was performed on each of the 73 isolates. Twenty isolates displayed a marked decrease in azole susceptibility. Amino acid substitutions were detected in more than two-thirds of the strains. In all, 23 distinct substitutions were identified. Four have not been described previously, among which N136Y and Y447H are suspected to be involved in azole resistance. We suggest that the high genetic polymorphism of ERG11 must be consid...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Florent Morio, Cedric Loge, Bernard Besse, Christophe Hennequin, Patrice Le Pape Tags: Mycology Source Type: journals

kDNA minicircle signatures of Leishmania (Viannia) braziliensis in oral and nasal mucosa from mucosal leishmaniasis patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Polymerase chain reaction (PCR) and low-stringency single-specific primer PCR (LSSP-PCR) analyses were used to detect Leishmania (Viannia) braziliensis DNA and investigate kDNA signatures of parasite populations present in oral and nasal mucosa lesions from mucosal leishmaniasis patients. A total of 25 samples from 22 patients were processed by specific PCR/hybridization assays. Parasite DNA was detected in all samples analyzed. The intraspecific polymorphism of the variable region of L. (V.) braziliensis kDNA minicircles was also investigated by LSSP-PCR. Similar kDNA signatures were observed in parasites recove...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Fernanda Santos de Oliveira, Cláudia Maria Valete-Rosalino, Armando de Oliveira Schubach, Raquel da Silva Pacheco Tags: Parisitology Source Type: journals

Acute HIV infection among pregnant women in MalawiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: There are limited data on acute HIV infection (AHI) prevalence during pregnancy. Malawian pregnant women admitted in the third trimester and meeting eligibility criteria underwent dual HIV rapid antibody testing. AHI prevalence was retrospectively detected through HIV RNA pooling of seronegative plasma. Among 3,825 pregnant women screened, dual HIV rapid testing indicated that 30.2% were HIV positive, 69.7% were HIV negative, and 0.1% were indeterminate. Sensitivity and specificity of dual rapid testing was 99.0% and 98.7%, respectively. Of 2,666 seronegative specimens, 2,327 had samples available for HIV RNA poo...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Cynthia L. Gay, Victor Mwapasa, David M. Murdoch, Jesse J. Kwiek, Susan A. Fiscus, Steven R. Meshnick, Myron S. Cohen Tags: Virology Source Type: journals

Triplex real-time polymerase chain reaction assay for simultaneous detection of Staphylococcus aureus and coagulase-negative staphylococci and determination of methicillin resistance directly from positive blood culture bottlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here a 1-step, triplex real-time polymerase chain reaction (PCR) assay for the detection and identification of staphylococci directly from signal-positive blood culture bottles containing Gram-positive cocci in clusters (GPCC). The triplex assay targeted and detected tuf, nuc, and mecA genes in a single tube and had a detection limit of 105 CFU/mL for each gene target. A total of 341 GPCC-positive blood culture bottles were collected between November 12, 2008, and August 11, 2009. Among them, 230 methicillin-resistant coagulase-negative staphylococci (CoNS), 54 methicillin-susceptible CoNS, 22 methicillin-resis...
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Abdullah Kilic, Kenneth L. Muldrew, Yi-Wei Tang, A. Celal Basustaoglu Tags: Bacteriology Source Type: journals

New cfiA variant and novel insertion sequence elements in carbapenem-resistant Bacteroides fragilis isolates from KoreaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reconfirmed the correlation between ISs and carbapenem resistance in B. fragilis. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 12, 2010 Category: Microbiology Authors: Kyoung Ho Roh, Sinyoung Kim, Chang-Ki Kim, Jong Hwa Yum, Myung Sook Kim, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee, June Myung Kim, Yunsop Chong Tags: Bacteriology Source Type: journals

Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Ho, K. M., Litton, E. Tags: Erratum Source Type: journals

Comment on: Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Ho, K. M. Tags: Letters to the Editor Source Type: journals

Predictors of mortality and impact of aminoglycosides on outcome in listeriosis in a retrospective cohort study--authors' responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Mitja, O., Pigrau, C., Ruiz, I., Vidal, X., Almirante, B., Planes, A.-M., Molina, I., Rodriguez, D., Pahissa, A. Tags: Letters to the Editor Source Type: journals

Comment on: Predictors of mortality and impact of aminoglycosides on outcome in listeriosis in a retrospective cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Lorber, B. Tags: Letters to the Editor Source Type: journals

Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected children--authors' responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Puthanakit, T., on behalf of the HIV-NAT 045 Study Team Tags: Letters to the Editor Source Type: journals

Comment on: Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Neely, M. N., Rakhmanina, N. Y. Tags: Letters to the Editor Source Type: journals

Risk factors and prognosis of post-operative pneumonia due to Pseudomonas aeruginosa following cardiac surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Allou, N., Kermarrec, N., Muller, C., Thabut, G., Philip, I., Lucet, J.-C., Montravers, P. Tags: Research letters Source Type: journals

A survey of the identification and susceptibility testing of anaerobes in diagnostic microbiology laboratories in Scotland, UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Smith, A. J., Lockhart, D. E. A., Tyers, A., Poxton, I. R. Tags: Research letters Source Type: journals

Antibiotic susceptibility profiles of European Bacteroides fragilis with reduced carbapenem susceptibilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Hawser, S. P., Hackel, M., Hoban, D. J. Tags: Research letters Source Type: journals

In vitro activity of ceftobiprole against Gram-positive and Gram-negative bacteria isolated from humans and animalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Silva, N., Radhouani, H., Goncalves, A., Araujo, C., Rodrigues, J., Igrejas, G., Poeta, P. Tags: Research letters Source Type: journals

Squalamine, an original chemosensitizer to combat antibiotic-resistant Gram-negative bacteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Lavigne, J.-P., Brunel, J.-M., Chevalier, J., Pages, J.-M. Tags: Research letters Source Type: journals

Low prevalence of 16S methylases among extended-spectrum-{beta}-lactamase-producing Enterobacteriaceae from a Turkish hospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Bercot, B., Poirel, L., Ozdamar, M., Hakko, E., Turkoglu, S., Nordmann, P. Tags: Research letters Source Type: journals

Detection of GES-5-producing Klebsiella pneumoniae in BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Picao, R. C., Santos, A. F., Nicoletti, A. G., Furtado, G. H., Gales, A. C. Tags: Research letters Source Type: journals

Reassessment of intravenous antibiotic therapy using a reminder or direct counsellingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study shows a modest impact of only distributing a questionnaire aimed at reminding physicians to reassess therapy, whereas systematic IDP intervention improves the modification rate. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Lesprit, P., Landelle, C., Girou, E., Brun-Buisson, C. Tags: Original research Source Type: journals

Risk factors for bloodstream infection with Klebsiella pneumoniae producing VIM-1 metallo-{beta}-lactamaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Stay in an ICU, prior use of carbapenems and prior exposure to >3 different classes of antibiotics were independent predictors for VPKP BSIs. These findings provide guidance for antibiotic policies and infection control strategies to contain the spread of VPKP. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Daikos, G. L., Vryonis, E., Psichogiou, M., Tzouvelekis, L. S., Liatis, S., Petrikkos, P., Kosmidis, C., Tassios, P. T., Bamias, G., Skoutelis, A. Tags: Original research Source Type: journals

Linezolid use for treatment of multidrug-resistant and extensively drug-resistant tuberculosis, New York City, 2000-06Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The majority of MDR TB patients on linezolid had favourable treatment outcomes, although treatment was complicated by adverse events that required extensive clinical management. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Anger, H. A., Dworkin, F., Sharma, S., Munsiff, S. S., Nilsen, D. M., Ahuja, S. D. Tags: Original research Source Type: journals

European Surveillance of Antimicrobial Consumption (ESAC): outpatient systemic antimycotic and antifungal use in EuropeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We present for the first time a standardized and validated data set of outpatient systemic antimycotic and antifungal use in Europe. Our study demonstrates a variation of antimycotic and antifungal use in Europe, as striking as that of antibiotic use. The ESAC data facilitate the auditing of antimycotic and antifungal prescribing, and the evaluation of the implementation of guidelines and public health policies to promote their judicious use. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Adriaenssens, N., Coenen, S., Muller, A., Vankerckhoven, V., Goossens, H., on behalf of the ESAC Project Group Tags: Original research Source Type: journals

Overall survival and fungal infection-related mortality in patients with invasive fungal infection and neutropenia after myelosuppressive chemotherapy in a tertiary care centre from 1995 to 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Compared with 1995–2001, IFI-related mortality decreased and OS in patients with IFI increased significantly in recent years. Improved OS was associated with controlled haematological disease, certainty of IFI diagnosis (possible), younger age, time period 2002–06 and the use of novel antifungals. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Hahn-Ast, C., Glasmacher, A., Muckter, S., Schmitz, A., Kraemer, A., Marklein, G., Brossart, P., von Lilienfeld-Toal, M. Tags: Original research Source Type: journals

Relative contributions of baseline patient characteristics and the choice of statistical methods to the variability of genotypic resistance scores: the example of didanosineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Baseline patient characteristics contribute more than the choice of statistical method to the variability of the mutations to be included in the genotypic resistance scores. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Assoumou, L., Houssaini, A., Costagliola, D., Flandre, P., on behalf of the Standardization and Clinical Relevance of HIV Drug Resistance Testing Project from the Forum for Collaborative HIV Research Tags: Original research Source Type: journals

Factors associated with proviral DNA HIV-1 tropism in antiretroviral therapy-treated patients with fully suppressed plasma HIV viral load: implications for the clinical use of CCR5 antagonistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Proviral DNA tropism determination should be required, even for patients with a CD4 nadir cell count >350 cells/mm3, before CCR5 antagonists are used in patients with a fully suppressed plasma viral load. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Soulie, C., Fourati, S., Lambert-Niclot, S., Malet, I., Wirden, M., Tubiana, R., Valantin, M.-A., Katlama, C., Calvez, V., Marcelin, A.-G. Tags: Original research Source Type: journals

Despite being highly diverse, immunovirological status strongly correlates with clinical symptoms during primary HIV-1 infection: a cross-sectional study based on 674 patients enrolled in the ANRS CO 06 PRIMO cohortEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Plasma HIV-RNA, PBMC HIV-DNA and CD4 cell count values were highly diverse and correlated strongly with clinical status during PHI. Early diagnosis was not always associated with severe PHI. Combining PBMC HIV-DNA with HIV-RNA, CD4 cell count and clinical symptoms would have allowed identification of 179 patients (26.5%) at high risk of rapid disease progression who did not meet current guidelines for early treatment initiation. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Ghosn, J., Deveau, C., Chaix, M.-L., Goujard, C., Galimand, J., Zitoun, Y., Allegre, T., Delfraissy, J.-F., Meyer, L., Rouzioux, C., on behalf of the ANRS PRIMO Cohort Tags: Original research Source Type: journals

Fluvastatin as an adjuvant to pegylated interferon and ribavirin in HIV/hepatitis C virus genotype 1 co-infected patients: an open-label randomized controlled studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Fluvastatin addition to standard therapy did not significantly increase the SVR rate in HIV/HCV genotype 1 co-infected patients; however, it did significantly improve the RVR. Further studies are needed to confirm these promising results and to investigate the mechanisms of action of statins in HCV infection. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Milazzo, L., Caramma, I., Mazzali, C., Cesari, M., Olivetti, M., Galli, M., Antinori, S. Tags: Original research Source Type: journals

Comparison of the 'Denver regimen' against acute tuberculosis in the mouse and guinea pigEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Treatment with rifampicin/isoniazid/pyrazinamide administered at human-equivalent doses is much more potent against acute TB infection in guinea pigs than in mice. Our findings have important implications for the use of alternative animal models in testing novel TB drug regimens and for modelling M. tuberculosis persistence. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Ahmad, Z., Nuermberger, E. L., Tasneen, R., Pinn, M. L., Williams, K. N., Peloquin, C. A., Grosset, J. H., Karakousis, P. C. Tags: Original research Source Type: journals

Activity of telavancin against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) in vitro and in an in vivo mouse model of bacteraemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These in vitro and pre-clinical in vivo studies demonstrate that telavancin has the potential to be efficacious in infections caused by hVISA. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Hegde, S. S., Skinner, R., Lewis, S. R., Krause, K. M., Blais, J., Benton, B. M. Tags: Original research Source Type: journals

Staphylococcus aureus with reduced glycopeptide susceptibility in Liverpool, UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Laboratory strategies to reduce morbidity associated with hGISA should focus on testing for hGISA in bacteraemic (rather than colonizing) MRSA isolates in patients with recurrent S. aureus bacteraemia following glycopeptide exposure. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Kirby, A., Graham, R., Williams, N. J., Wootton, M., Broughton, C. M., Alanazi, M., Anson, J., Neal, T. J., Parry, C. M. Tags: Original research Source Type: journals

Semi-selective broth improves screening for methicillin-resistant Staphylococcus aureusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions TSB-SSI was superior to both NB and direct plating on ChromID MRSA and BA. Despite re-using swabs for the study, we showed that routine diagnostic screening could be significantly improved, using a semi-selective enrichment broth. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Bocher, S., Middendorf, B., Westh, H., Mellmann, A., Becker, K., Skov, R., Friedrich, A. W. Tags: Original research Source Type: journals

Binding of ceftaroline to penicillin-binding proteins of Staphylococcus aureus and Streptococcus pneumoniaeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The high affinities of ceftaroline for MRSA PBP2a, MSSA PBPs 1–3 and S. pneumoniae PBP2x/2a/2b support the potential efficacy of ceftaroline in the treatment of infections caused by MRSA and S. pneumoniae. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Moisan, H., Pruneau, M., Malouin, F. Tags: Original research Source Type: journals

Determination of the susceptibility of Mycobacterium tuberculosis to pyrazinamide in liquid and solid media assessed by a colorimetric nitrate reductase assayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The CONRAS tests were rapid, cheap and easy to perform and interpret. Both tests should be evaluated on extended strain batteries in multicentre studies before they can be considered for use in susceptibility testing of M. tuberculosis to pyrazinamide in resource-limited settings. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Syre, H., Ovreas, K., Grewal, H. M. S. Tags: Original research Source Type: journals

In vitro interaction of posaconazole with calcineurin inhibitors and sirolimus against zygomycetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The clinical significance of these findings is unclear, but further studies are warranted given the potential for concomitant use of these agents in transplant patients treated for zygomycosis. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Narreddy, S., Manavathu, E., Chandrasekar, P. H., Alangaden, G. J., Revankar, S. G. Tags: Original research Source Type: journals

Fungicidal activity of miconazole against Candida spp. biofilmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions ROS levels increased in all Candida biofilms upon addition of miconazole. However, ROS induction was not the only factor that underlies its fungicidal activity, as quenching of ROS did not lead to an enhanced survival of biofilm cells. ROS-induced apoptosis was not observed in C. albicans cells after miconazole treatment. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Vandenbosch, D., Braeckmans, K., Nelis, H. J., Coenye, T. Tags: Original research Source Type: journals

Attenuation of Pseudomonas aeruginosa virulence factors and biofilms by co-encapsulation of bismuth-ethanedithiol with tobramycin in liposomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These data suggest that treatment of P. aeruginosa with tobramycin and bismuth, as measured by the changes in quorum sensing, virulence factors and biofilms, is most effective when delivered as a liposomal formulation at a lower concentration compared with the free formulation. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - March 12, 2010 Category: Microbiology Authors: Alipour, M., Suntres, Z. E., Lafrenie, R. M., Omri, A. Tags: Original research Source Type: journals