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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 38.

Outcome of Penile Revascularization for Arteriogenic Erectile Dysfunction After Pelvic Fracture Urethral Injuries
Conclusion: Penile arterial revascularization in select patients can allow for successful treatment of PFUIs and the refractory erectile dysfunction caused by them.
Source: Urology - December 1, 2012 Category: Urology & Nephrology Authors: Jack M. Zuckerman, Kurt A. McCammon, Britton E. Tisdale, Larry Colen, Ted Uroskie, Paul McAdams, Gerald H. Jordan Tags: Reconstructive Urology Source Type: research

Effect of Urinary Incontinence and Its Subtypes on Quality of Life of Women in Eastern Turkey
Conclusion: Our results have shown that, regardless of different factors, UI has significant negative effects on QOL. The presented data emphasize the importance of the high prevalence of UI in our region and its negative effects on QOL. Thus, additional policies are needed for the prevention of the negative effects of UI.
Source: Urology - December 1, 2012 Category: Urology & Nephrology Authors: Fatih Firdolas, Rahmi Onur, Suleyman Erhan Deveci, Suheyla Rahman, Feyza Sevindik, Yasemin Acik Tags: Female Urology Source Type: research

Primary malignant pancreatic neoplasms in children and adolescents: A 20year experience
Abstract: Background: Malignant pancreatic neoplasms in children and adolescents are rare. The clinical presentation, pathologic characteristics, management, and outcomes at two institutions are discussed.Methods: We retrospectively reviewed all pediatric patients (age
Source: Journal of Pediatric Surgery - December 1, 2012 Category: Surgery Authors: Yesenia Rojas, Carla L. Warneke, Chetan A. Dhamne, Kuojen Tsao, Jed G. Nuchtern, Kevin P. Lally, Sanjeev A. Vasudevan, Andrea A. Hayes-Jordan, Darrell L. Cass, Cynthia E. Herzog, M. John Hicks, Eugene S. Kim, Mary T. Austin Tags: PAPS Papers Source Type: research

Hybrid Thoracoabdominal Aortic Aneurysm Repair: Current Perspectives
Open repair of thoracoabdominal aortic aneurysms (TAAAs) is associated with significant morbidity and mortality. While open repair has remained the mainstay for treatment, this major surgical reconstruction is associated with a variety of complications due to the cardiopulmonary stress of this large-scale operation. Some of these complications include respiratory failure, heart failure, and acute renal failure, as well as spinal cord ischemia. With the progression of endovascular stent-graft technology, the development of a staged hybrid technique was first reported in the literature in 2004. The tenet of the hybrid approa...
Source: Seminars in Vascular Surgery - December 1, 2012 Category: Surgery Authors: Dean Yamaguchi, William D. Jordan Source Type: research

Introduction
AORTIC ANEURYSMS REMAIN a life-threatening and devastating problem that faces our aging population. We have long recognized that aortic aneurysms and death associated with aneurysm repair has been the 13th leading cause of death in the US population. Relative to this growing health care problem, open aneurysm repair was first initiated in the 1950s and has been established as a durable repair yet formidable operation that creates a considerable amount of physiologic stress for our patients. It is not uncommon that elderly patients never present for this repair because of the gravity of this procedure. Likewise, the endovas...
Source: Seminars in Vascular Surgery - December 1, 2012 Category: Surgery Authors: William D. Jordan Source Type: research

Associations of educational attainment, occupation and community poverty with hip osteoarthritis
Conclusion:Our data provide evidence that hip OA outcomes are associated with both education and community SES measures, associations which remained after adjustment for covariates and all SES measures. © 2012 by the American College of Rheumatology
Source: Arthritis Care and Research - December 1, 2012 Category: Rheumatology Authors: Rebecca J. Cleveland, Todd A. Schwartz, Lindsay Penny Prizer, Randy Randolph, Britta Schoster, Jordan B. Renner, Joanne M. Jordan, Leigh F. Callahan Tags: Original Article Source Type: research

Organisational values and organisational commitment: do nurses’ ethno‐cultural differences matter?
ConclusionFindings confirm the role of culture and ethnicity in the perception of organisational values and the level of organisational commitment among nurses. Implications for nursing managementAssessing ethno‐cultural differences in organisational values and organisational commitment provides a fuller understanding of nurses' ability to adjust to their work environment and helps nurse managers devise means to increase nurses' commitment.
Source: Journal of Nursing Management - December 1, 2012 Category: Nursing Authors: Tova Hendel, Ilya Kagan Tags: Original Article Source Type: research

How close are we to targeting the leukemia stem cell?
There are a number of approaches for selective targeting of leukemic stem cells (LSCs). These include targeting stem-cell properties, such as self-renewal, inducing cycling of quiescent LSCs to sensitize them to conventional agents, employing or inducing immune-based mechanisms, and targeting tumor-specific physiology. Agents such as parthenolide inhibit the ability of leukemic stem cells to respond to oxidative stress and make leukemic stem cells and bulk leukemic cells susceptible to cell death, while normal stem cells remain relatively unharmed by these agents. The major mechanism of action of these small molecules appe...
Source: Best Practice and Research. Clinical Haematology - December 1, 2012 Category: Hematology Authors: Shanshan Pei, Craig T. Jordan Source Type: research

Norepinephrine transporter function and human cardiovascular disease
Approximately 80–90% of the norepinephrine released in the brain or in peripheral tissues is taken up again through the neuronal norepinephrine transporter (NET). Pharmacological studies with NET inhibitors showed that NET has opposing effects on cardiovascular sympathetic regulation in the brain and in the periphery. Furthermore, NET is involved in the distribution of sympathetic activity between vasculature, heart, and kidney. Genetic NET dysfunction is a rare cause of the postural tachycardia syndrome. The condition is characterized by excessive adrenergic stimulation of the heart, particularly with standing. Conv...
Source: AJP: Heart and Circulatory Physiology - December 1, 2012 Category: Cardiology Authors: Schroeder, C., Jordan, J. Tags: Special Review Articles REVIEWS Source Type: research

Neonatal nurse practitioners in iran: are we facing any challenges in the beginning?
Abstract With an increased demand in the clinical field, physicians and nursing leaders in Iran have been working on developing an advanced practice nursing role. A neonatal nurse practitioner (NNP) program was developed by Tehran Medical University with cooperation of Iran's Neonatologist Association. The first group of master's students started their formal education in September 2009 with the principal goal of becoming "clinical nurse practitioners" ready to work in the neonatal intensive care unit as "first responders." Neonatal nurse practitioners are an integral and important aspect of the interdisciplinary t...
Source: Advances in Neonatal Care - November 30, 2012 Category: Nursing Authors: Kadivar M, Mozafarinia SM Tags: Adv Neonatal Care Source Type: research

Novel coronavirus infection - update
In addition to the fatal case of novel coronavirus in Saudi Arabia reported to WHO on 28 November, two fatal cases in Jordan have been reported to WHO today, bringing the total of laboratory-confirmed cases to nine.
Source: WHO Disease Outbreaks - November 30, 2012 Category: Infectious Diseases Source Type: news

Re: Predictive Factors and Management of Steinstrasse After Shock Wave Lithotripsy in Pediatric Urolithiasis—A Multivariate Analysis Study
B. Onal, S. Citgez, N. Tansu, C. Demirdag, C. Dogan, B. Gonul, O. Demirkesen, C. Obek and A. Erozenci Department of Urology, University of Istanbul Cerrahpasa Medical Faculty, Istanbul, Turkey
Source: The Journal of Urology - November 30, 2012 Category: Urology & Nephrology Authors: Dean Assimos Tags: Urolithiasis/Endourology Source Type: research

Association of allelic variants of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase with thrombosis or ocular involvement in Behçet's disease: A systematic review and meta-analysis.
CONCLUSIONS: Factor V Leiden could be responsible for some thrombotic events in at least Turkish patients. However, this relationship has to be demonstrated from a pathogenic point of view. PMID: 23207285 [PubMed - as supplied by publisher]
Source: Autoimmunity Reviews - November 30, 2012 Category: Allergy & Immunology Authors: Chamorro AJ, Marcos M, Hernández-García I, Calvo A, Mejia JC, Cervera R, Espinosa G Tags: Autoimmun Rev Source Type: research

Actinopolyspora saharensis sp. nov., a novel halophilic actinomycete isolated from a Saharan soil of Algeria.
Abstract A novel halophilic actinomycete, strain H32(T), was isolated from a Saharan soil sample collected in El-Oued province, south Algeria. The isolate was characterized by means of polyphasic taxonomy. Optimal growth was determined to occur at 28-32 °C, pH 6.0-7.0 and in the presence of 15-25 % (w/v) NaCl. The strain was observed to produce abundant aerial mycelium, which formed long chains of rod-shaped spores at maturity, and fragmented substrate mycelium. The cell wall was determined to contain meso-diaminopimelic acid and the characteristic whole-cell sugars were arabinose and galactose. The predominant ...
Source: Antonie van Leeuwenhoek - November 30, 2012 Category: Microbiology Authors: Meklat A, Bouras N, Zitouni A, Mathieu F, Lebrihi A, Schumann P, Spröer C, Klenk HP, Sabaou N Tags: Antonie Van Leeuwenhoek Source Type: research

The predicated demise of racemic new molecular entities is an exaggeration
Nature Reviews Drug Discovery 11, 972 (2012). doi:10.1038/nrd3657-c1 Authors: Israel Agranat, Silvya R. Wainschtein & Enav Z. Zusman Since 2003, Nature Reviews Drug Discovery has consistently published reports of annual new drug approvals by the US Food and Drug Administration (FDA) (2011 FDA drug approvals. Nature Rev. Drug Discov.11, 91–94 (2012)). These informative
Source: Nature Reviews Drug Discovery - November 30, 2012 Category: Drugs & Pharmacology Authors: Israel AgranatSilvya R. WainschteinEnav Z. Zusman Tags: Correspondence Source Type: research

Influence of Health Providers on Pediatrics' Immunization Rate
To identify the immunization providers’ characteristics associated with immunization rate in children younger than 2 years. A cohort and a cluster sampling design were implemented; 528 children between 18 and 70 months of age were sampled in five public health clinics in Mosul-Iraq. Providers’ characterizations were obtained. Immunization rate for the children was assessed. Risk factors for partial immunization were explored using both bivariate analyses and multi-level logistic regression models. Less than half of the children had one or more than one missed dose, considered as partial immunization cases. The ...
Source: Journal of Tropical Pediatrics - November 30, 2012 Category: Tropical Medicine Authors: Al-lela, O. Q. B., Baidi Bahari, M., Al-abbassi, M. G., Salih, M. R. M., Basher, A. Y. Tags: Original Papers Source Type: research

The Impact of Occupation on Child Health in a Palestinian Refugee Camp
This article focuses on child health in the Palestinian refugee camp of Dheisheh in the West Bank region of the Occupied Palestinian Territories. Thirty in-depth interviews were carried out with parents to determine their perceptions of their children’s health. The questions related to physical, mental and social well-being, access to health facilities, factors that were likely to hinder health and measures that could be implemented to improve child health. The study was carried out prior to and during the Gaza War in December 2008 that resulted in the deaths of 1380 Palestinians including 431 children and 112 women ...
Source: Journal of Tropical Pediatrics - November 30, 2012 Category: Tropical Medicine Authors: Basak, P. Tags: Original Papers Source Type: research

S390 lifetime is involved in phototropin kinase activation [Signal Transduction]
Phototropin (phot) is a light-regulated protein kinase that mediates a variety of photoresponses in plants, such as phototropism, chloroplast positioning, and stomata opening. Arabidopsis has two homologues, phot1 and phot2, that share physiological functions depending on light intensity. A phot molecule has two photoreceptive light oxygen voltage-sensing domains, LOV1 and LOV2, and a Ser/Thr kinase domain. The LOV domains undergo a photocycle upon blue light (BL) stimulation, including transient adduct formation between the chromophore and a conserved cysteine (S390 intermediate) that leads to activation of the kinase. To...
Source: Journal of Biological Chemistry - November 30, 2012 Category: Chemistry Authors: Okajima, K., Kashojiya, S., Tokutomi, S. Tags: Plant Biology Source Type: research

Lifetime risk and age of diagnosis of symptomatic knee osteoarthritis in the US
Conclusion:The diagnosis of symptomatic knee OA occurs relatively early in life suggesting that prevention programs should be offered relatively early in the life course. Further research is needed to understand the future burden of healthcare utilization resulting from earlier diagnosis of knee OA. © 2012 by the American College of Rheumatology
Source: Arthritis Care and Research - November 30, 2012 Category: Rheumatology Authors: Elena Losina, Alexander M. Weinstein, William M. Reichmann, Sara A. Burbine, Daniel H. Solomon, Meghan E. Daigle, Benjamin N. Rome, Stephanie P. Chen, David J. Hunter, Lisa G. Suter, Joanne M. Jordan, Jeffrey N. Katz Tags: Original Article Source Type: research

Effects of visual, auditory, and kinesthetic imagery interventions on dancers’ plié arabesques
The goal of this study was to examine the influence of visual, auditory, and kinesthetic delivery modes of Franklin Method images (anatomical bone rhythms, metaphorical image, and tactile aid, respectively) on the performance of college dancers’ plié arabesques by assessing its influence on three measures: plié depth; maintenance of rotation; and simultaneous use of hip, knee, and ankle (Tri-fold). Eighteen participants performed a series of plié arabesques during three visits over a period of two months; at each visit, pliés were performed before and after an image intervention, and the change in mean Likert scale r...
Source: Journal of Imagery Research in Sport and Physical Activity - November 29, 2012 Category: Sports Medicine Tags: dance imagery learning styles intervention Source Type: research

Delivering Babies and Smiles to Syrian Refugees - 17 October 2012
CYBER CITY, Jordan- To one new mother, whose baby she delivered safely in a clinic, she is like a second mother. To another, whose breast cancer she detected, she is a ‘saving angel.
Source: UNFPA News - November 29, 2012 Category: Global & Universal Source Type: news

Learning Opportunities Help Syrian Women Cope with Camp Life - 08 November 2012
This story, published by the Jordan Times, describes activities organized by UNFPA and partners to help Syrian refugees pass the time productively in the Za'atari camp that now hosts some 40,000 people, many of them women and children.
Source: UNFPA News - November 29, 2012 Category: Global & Universal Source Type: news

Epidemiology of, and surveillance of, media worker homicide in Iraq (2003-2011) - Collinson L, Wilson N.
Background There is controversy over estimates of the civilian death toll associated with violent conflict in Iraq. Objective To describe the epidemiology of media worker homicide in Iraq in order to describe its relationship with the homicide level for...
Source: SafetyLit: All (Unduplicated) - November 29, 2012 Category: Global & Universal Tags: Occupational Issues Source Type: news

The interactive effect of fear and humour appeals, gender & the level of involvement on attitude toward safe driving - Kabiri Z, Hakimara M.
Aims Road trauma is recognised as a serious problem both in Iran and internationally. Produce and exposure of persuasive advertisings is an important strategy that persuade attitude including Unitarian attitude, value expressive attitude and general attitu...
Source: SafetyLit: All (Unduplicated) - November 29, 2012 Category: Global & Universal Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news

The impact of socio economic factors on injuries in Tehran, IR Iran - Moghisi A, Farshad A.
Introduction Tehran is the capital city of IR Iran with about 12 000 000 inhabitants. Consisting of 22 districts. Injuries happen with different rate and type in different zones. Objectives To improve urban management in terms of injury prevention. ...
Source: SafetyLit: All (Unduplicated) - November 29, 2012 Category: Global & Universal Tags: Falls Source Type: news

External causes of injuries in Tehran, Iran: a household survey - Zangi M, Mohammadi R, Saadat S.
Background Injuries continue to be significant health problems and leading causes of death and disability in many populations. Aims A household survey was conducted to determine the external causes of injuries among people living in Tehran, Iran. Met...
Source: SafetyLit: All (Unduplicated) - November 29, 2012 Category: Global & Universal Tags: Falls Source Type: news

Post-crash Management of road traffic injury victims in Iran. Stakeholders' views on current barriers and potential facilitators - Khorasani-Zavareh D, Khankeh H, Mohammadi R, Laflamme L, Bikmoradi A, Haglund B.
Background Road traffic injuries are a major public health problem, especially in low- and middleincome countries. Post-crash management can play a significant role in minimising crash consequences and saving lives. Iran has one of the highest mortality ra...
Source: SafetyLit: All (Unduplicated) - November 29, 2012 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The impact of safe community initiatives on helmet wearing rate and motorcyclists' death in 14 cites of Iran - Moghisi A, Mohammadi R, Svanstrom L.
Background Motorcycles' riders have the highest public health burden. Since helmet reduces the risk of death by 42% to 69% it seems that the main contributing factors is improper helmet usage by motorcyclists. Objective To determine the impact of safe c...
Source: SafetyLit: All (Unduplicated) - November 29, 2012 Category: Global & Universal Tags: Community-Based Prevention Source Type: news

Injury patterns and safety behaviour of child pedestrians in the ultra Orthodox Jewish Community - Silbinger O, Levi S, Hamenachem Y, Klein M, Ivancovsky M.
Background Road crashes are a primary cause of injury among children in Israel. The Ultra-Orthodox Jewish (UOJ) population in Israel is characterised by low socioeconomic status, large families, low employment, and a low level of secular educational attain...
Source: SafetyLit: All (Unduplicated) - November 29, 2012 Category: Global & Universal Tags: Age: Infants and Children Source Type: news

It’s official: Mazor Robotics chooses Orlando for U.S. HQ
Christmas is coming early. In August, word broke that Tel Aviv, Israel-based Mazor Robotics Ltd. was shopping Orlando as a potential U.S. headquarters. And now it's official: Mazor is coming to Orlando in January with 34 employees earning an average salary north of $80,000 per year; the company manufactures and sells robotic spinal surgery devices. Check here to search job openings. The company will occupy 15,000 square feet of space in the BioResearch Center, formerly known as the bioscience…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - November 29, 2012 Category: Pharmaceuticals Authors: Abraham Aboraya Source Type: research

Diverging breast and stomach cancer incidence and survival in migrants in The Netherlands, 1996-2009.
Conclusion. The lower incidence rates of breast and cardia stomach cancer in migrants as well as their higher non-cardia stomach cancer rates reflect most likely early life exposures including pregnancy and/or dietary patterns during life-course. While higher relative excess mortality from breast cancer in migrant women might point toward inadequate access and treatment in this group, lower excess mortality from (especially non-cardia) stomach cancer remains to be explained. PMID: 23193960 [PubMed - as supplied by publisher]
Source: Acta Oncologica - November 29, 2012 Category: Cancer & Oncology Authors: Arnold M, Aarts MJ, Siesling S, Aa MV, Visser O, Coebergh JW Tags: Acta Oncol Source Type: research

High-resolution HLA haplotype frequencies of stem cell donors in Germany with foreign parentage: How can they be used to improve unrelated donor searches?
Abstract In hematopoietic stem cell transplantation, human leukocyte antigens (HLA), usually HLA loci A, B, C, DRB1 and DQB1, are required to check histocompatibility between a potential donor and the recipient suffering from a malignant or non-malignant blood disease. As databases of potential unrelated donors are very heterogeneous with respect to typing resolution and number of typed loci, donor registries make use of haplotype frequency-based algorithms to provide matching probabilities for each potentially matching recipient/donor pair. However, it is well known that HLA allele and haplotype frequencies differ...
Source: Human Immunology - November 29, 2012 Category: Allergy & Immunology Authors: Pingel J, Solloch UV, Hofmann JA, Lange V, Ehninger G, Schmidt AH Tags: Hum Immunol Source Type: research

Quantitative proteomics reveal factors regulating RNA biology as dynamics targets of stress-induced sumoylation in Arabidopsis.
Abstract The stress-induced attachment of small ubiquitin-like modifier (SUMO) to a diverse collection of nuclear proteins regulating chromatin architecture, transcription, and RNA biology has been implicated in protecting plants and animals against numerous environmental challenges. To better understand stress-induced SUMOylation, we combined stringent purification of SUMO conjugates with isobaric tag for relative and absolute quantification (iTRAQ) mass spectrometry and an advanced method to adjust for sample-to-sample variation to study quantitatively the SUMOylation dynamics of intact Arabidopsis seedlings subj...
Source: Molecular and Cellular Proteomics : MCP - November 29, 2012 Category: Molecular Biology Authors: Miller MJ, Scalf M, Rytz TC, Hubler SL, Smith LM, Vierstra RD Tags: Mol Cell Proteomics Source Type: research

Cellular localization of mitotic RAD21 with repetitive amino acid motifs in Allium cepa.
Abstract Onion can be used in experimental observation of mitotic cell division in plant science because its chromosome is large and easy to observe. However, molecular genetic studies are difficult in onion because of its large genome size, and only limited information of onion genes has been available to date. Here we cloned and characterized an onion homologue of mitotic RAD21 gene, AcRAD21-1, to develop a molecular marker of mitosis. The N-terminal, middle, and C-terminal regions of deduced AcRAD21-1 protein sequence were conserved with Arabidopsis SYN4/AtRAD21.3 and rice OsRAD21-1, whereas three characteristic...
Source: Gene - November 29, 2012 Category: Genetics & Stem Cells Authors: Suzuki G, Nishiuchi C, Tsuru A, Kako E, Li J, Yamamoto M, Mukai Y Tags: Gene Source Type: research

Identification of the highly accumulated microRNA*s in Arabidopsis (Arabidopsis thaliana) and rice (Oryza sativa).
Abstract Plant microRNAs (miRNAs) are crucial for the regulation of gene expression, which is involved in almost all the important biological processes. In the cytoplasm, the miRNA strand is selectively incorporated into a specific Argonaute (AGO)-associated gene silencing complex, while the miRNA* is degraded rapidly. Thus, most miRNA*s were thought to be biologically meaningless. Interestingly, several recent reports in both plants and animals have shaken this notion. Many miRNA*s were demonstrated to possess regulatory roles in gene expression. However, the low accumulation levels of most miRNA*s raise the quest...
Source: Gene - November 29, 2012 Category: Genetics & Stem Cells Authors: Shao C, Ma X, Xu X, Meng Y Tags: Gene Source Type: research

An Association Between L-arginine/ADMA Balance, Obesity and the Age of Asthma Onset Phenotype.
CONCLUSIONS: In late onset asthma phenotype, plasma ratios of L-arginine to ADMA may explain the inverse relationship of BMI to FeNO. In addition, these lower L-arginine/ADMA ratios are associated with reduced lung function, and increased respiratory symptoms frequency, suggesting a role in the pathobiology of the late onset phenotype. PMID: 23204252 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 29, 2012 Category: Respiratory Medicine Authors: Holguin F, Comhair SA, Hazen SL, Powers RJ, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung KF, Erzurum SC, Wenzel SE Tags: Am J Respir Crit Care Med Source Type: research

Language and utilisation of emergency care in Queensland
ConclusionThis study showed that there was a significant association between lower utilisation of emergency care and speaking languages other than English at home. Further researches are needed using in‐depth methodology to investigate if there are language barriers in accessing emergency care in Queensland.
Source: Emergency Medicine Australasia - November 29, 2012 Category: Emergency Medicine Authors: Ibrahim Mahmoud, Xiang‐Yu Hou, Kevin Chu, Michele Clark Tags: Original Research Source Type: research

Microencapsulation of Ozonated Red Pepper Seed Oil with Antimicrobial Activity and Application to Nonwoven Fabric
Abstract In recent years, functional fabrics possessing antimicrobial activity have drawn significant interest because antibiotic resistance is becoming widespread among pathogenic microorganisms. The aim of this study was to produce microcapsules incorporating ozonated red pepper seed oil with antimicrobial properties and apply them to nonwoven fabrics to prepare functional textiles. Red pepper seed oil (RPSO) was ozonated and microencapsulated via a complex coacervation method using gelatin (GE) and gum arabic (GA) as wall materials. While microencapsulation yield and oil loading decreased with increases in the amount of...
Source: Letters in Applied Microbiology - November 29, 2012 Category: Microbiology Authors: Figen Özyıldız, Senem Karagönlü, Guldemet Basal, Ataç Uzel, Oguz Bayraktar Tags: Original Article Source Type: research

Loss of the DNA Methyltransferase MET1 Induces H3K9 Hypermethylation at PcG Target Genes and Redistribution of H3K27 Trimethylation to Transposons in Arabidopsis thaliana
by Angelique Deleris, Hume Stroud, Yana Bernatavichute, Elizabeth Johnson, Gregor Klein, Daniel Schubert, Steven E. Jacobsen Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein-coding genes, while H3K9m2 is correlated with DNA methylation and is associated with transposons and repetitive sequences. Recently, ectopic genic DNA methylation in the CHG context (where H is any base except G) has b...
Source: PLoS Genetics - November 29, 2012 Category: Genetics & Stem Cells Authors: Angelique Deleris et al. Source Type: research

MicroRNA–Mediated Repression of the Seed Maturation Program during Vegetative Development in Arabidopsis
by Xurong Tang, Shaomin Bian, Mingjuan Tang, Qing Lu, Shengben Li, Xigang Liu, Gang Tian, Vi Nguyen, Edward W. T. Tsang, Aiming Wang, Steven J. Rothstein, Xuemei Chen, Yuhai Cui The seed maturation program only occurs during late embryogenesis, and repression of the program is pivotal for seedling development. However, the mechanism through which this repression is achieved in vegetative tissues is poorly understood. Here we report a microRNA (miRNA)–mediated repression mechanism operating in leaves. To understand the repression of the embryonic program in seedlings, we have conducted a genetic screen using a seed m...
Source: PLoS Genetics - November 29, 2012 Category: Genetics & Stem Cells Authors: Xurong Tang et al. Source Type: research

Prenatal stress and affective disorders in a population birth cohort
Conclusions: A time‐limited exposure to a severe threat during early gestation may be associated with an increased incidence of affective disorders in offspring. The third month of fetal development was a moment of special vulnerability.
Source: Bipolar Disorders - November 29, 2012 Category: Psychiatry Authors: Karine Kleinhaus, Susan Harlap, Mary Perrin, Orly Manor, Ronit Margalit‐Calderon, Mark Opler, Yehiel Friedlander, Dolores Malaspina Tags: Original Article Source Type: research

The D3cpv Cameleon reports Ca2+ dynamics in plant mitochondria with similar kinetics of the YC3.6 Cameleon, but with a lower sensitivity
Summary Mitochondria are key organelles involved in many aspects of plant physiology and, their ability to generate specific Ca2+ signatures in response to abiotic and biotic stimuli has been reported as one of their roles. The recent identification of the mammalian mitochondrial Ca2+ uniporter opens a new research area in plant biology. To study the mitochondrial Ca2+ handling, it is essential to have a reliable probe. Here we have reported the generation of an Arabidopsis transgenic line expressing the genetically encoded probe Cameleon D3cpv targeted to mitochondria, and compared its properties with the already known Cameleon YC3.6.
Source: Journal of Microscopy - November 29, 2012 Category: Laboratory Medicine Authors: G. LORO, C. RUBERTI, M. ZOTTINI, A. COSTA Source Type: research

New Sleep Articles Available from November
Now that you have dispatched with the turkey and the rest of the Thanksgiving feast, take a few moments before the rest of the holiday rush to review new sleep articles from November. Learn what an antihistamine is. Discover how best to sleep during pregnancy and whether insomnia can be an early sign of pregnancy. Finally understand the difference between fatigue and sleepiness. Consider whether lack of "morning wood" may suggest erectile dysfunction in men. What is it like to spend the first night using continuous positive airway pressure (CPAP)? Finally, read about the process of getting and using an oral appliance to tr...
Source: About Sleep Disorders - November 29, 2012 Category: Sleep Medicine Source Type: news

Mouse cytomegalovirus egress protein pM50 interacts with cellular endophilin‐A2
Summary The herpesvirus replication cycle comprises maturation processes in the nucleus and cytoplasm of the infected cells. After their nuclear assembly viral capsids translocate via primary envelopment towards the cytoplasm. This event is mediated by the nuclear envelopment complex, which is composed by two conserved viral proteins belonging to the UL34 and UL31 protein families. Here, we generated recombinant viruses, which express affinity tagged pM50 and/or pM53, the pUL34 and pUL31 homologs of the MCMV. We extracted pM50‐ and pM53‐associated protein complexes from infected cells and analyzed their composition aft...
Source: Cellular Microbiology - November 29, 2012 Category: Microbiology Authors: Frederic Lemnitzer, Verena Raschbichler, Dominika Kolodziejczak, Lars Israel, Axel Imhof, Susanne M. Bailer, Ulrich Koszinowski, Zsolt Ruzsics Tags: Research Article Source Type: research

Transcriptome analysis of intraspecific competition in Arabidopsis thaliana reveals organ-specific signatures related to nutrient acquisition and general stress response pathways
Conclusions: This study provides a comprehensive list of genes whose expression is affected by intraspecific competition in Arabidopsis. The outcome is a unique response that involves genes related to light, nutrient deficiency, abiotic stress, and defence responses.
Source: BMC Plant Biology - Latest articles - November 29, 2012 Category: Biology Authors: Frédéric MasclauxFriederike BruessowFabian SchweizerCaroline Gouhier-DarimontLaurent KellerPhilippe Reymond Source Type: research

Birds may spread, not halt, fever-bearing ticks
(University of Utah) Turkey raises and releases thousands of non-native guineafowl to eat ticks that carry the deadly Crimean-Congo hemorrhagic fever virus. Yet research suggests guineafowl eat few ticks, but carry the parasites on their feathers, possibly spreading the disease they were meant to stop, says a Turkish biologist working at the University of Utah.
Source: EurekAlert! - Infectious and Emerging Diseases - November 29, 2012 Category: Infectious Diseases Source Type: news

Novel Beta Coronavirus Mecca Linkage Raises Concerns
The commentary discusses the linkage of the first two confirmed novel betacoronavirus cases with Mecca, Saudi Arabia. (11/28/12 20:00)
Source: Recombinomics - November 28, 2012 Category: Infectious Diseases Source Type: news

Qatar Novel Beta Coronavirus Case In Mecca For Umrah Week
The commentary discusses the linkage of the first Qatar novel betacoronavirus case with a visit to Mecca, Saudi Arabia during Umrah week. (11/28/12 21:30)
Source: Recombinomics - November 28, 2012 Category: Infectious Diseases Source Type: news

The increased incidence of Mycoplasma pneumoniae in France in 2011 was polyclonal mainly involving M. pneumoniae type 1 strains
Abstract An increased incidence of Mycoplasma pneumoniae infections was reported in 2011 in two cities of France, Bordeaux and Caen. Two complementary molecular typing methods, PCR‐RFLP on adhesin P1 and multilocus variable number tandem repeat analysis (MLVA), were used to determine whether this phenomenon was clonal. In 2011, the percentage of M. pneumoniae‐positive patients doubled in both cities compared to 2010. Macrolide resistance remained stable at 8.3% of patients. Eighteen MLVA types were identified among 94 M. pneumoniae‐positive specimens, demonstrating that the phenomenon was multiclonal. Types P,J,U,...
Source: Clinical Microbiology and Infection - November 28, 2012 Category: Microbiology Authors: Sabine Pereyre, Arabella Touati, Joëlle Petitjean‐Lecherbonnier, Alain Charron, Astrid Vabret, Cécile Bébéar Tags: Research Note ‐ online only Source Type: research

Seminars in Oncology: "The Role of APC and SCF E3 Ubiquitin Ligase Complexes in Cell Cycle Regulation and Tumorigenesis"
Guest Speaker: Wenyi Wei, PhD Associate Professor, Pathology Beth Israel Deaconess Medical Center Boston, MA Tuesday, December 4, 2012 4 p.m. Jimmy Fund Auditorium For more information: claudia_steele@dfci.harvard.edu
Source: DF/HCC: Latest News - November 28, 2012 Category: Cancer & Oncology Tags: Announcements Source Type: news