P21 and p27: roles in carcinogenesis and drug resistance
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Review ArticlesAbde M. Abukhdeir, Ben Ho Park, Expert Reviews in Molecular Medicine, Volume 10 , pp e19AbstractHuman cancers arise from an imbalance of cell growth and cell death. Key proteins that govern this balance are those that mediate the cell cycle. Several different molecular effectors have been identified that tightly regulate specific phases of the cell cycle, including cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors. Notably, loss of expression or function of two G1-checkpoint CDK inhibitors has been implicated in the genesis or progression of many human malignancies. Additionally, there is a growin...
Source: Expert Reviews in Molecular Medicine - July 4, 2008 Category: Molecular Biology Source Type: journals
Therapeutic immunomodulators from nematode parasites
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This article reviews the evidence supporting this idea with respect to helminths of the phylum Nematoda (nematodes), considering data from human studies and animal models of inflammatory disease. The nature and mode of action of nematode-derived molecules with immunomodulatory properties are considered, and their therapeutic efficacy in models of autoimmunity and allergy described. The recent and future use of nematodes and their products in treating human disease are also discussed. (Source: Expert Reviews in Molecular Medicine)
Source: Expert Reviews in Molecular Medicine - July 4, 2008 Category: Molecular Biology Source Type: journals
Galectins: structure, function and therapeutic potential
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Review ArticlesRi-Yao Yang, Gabriel A. Rabinovich, Fu-Tong Liu, Expert Reviews in Molecular Medicine, Volume 10 , pp e17AbstractGalectins are a family of animal lectins that bind protein interactions with other cytoplasmic and nuclear proteins. Current research indicates that galectins play important roles in diverse physiological and pathological processes, including immune and inflammatory responses, tumour development and progression, neural degeneration, atherosclerosis, diabetes, and wound repair. Some of these have been discovered or confirmed by using genetically engineered mice deficient in a particular galectin. T...
Source: Expert Reviews in Molecular Medicine - July 4, 2008 Category: Molecular Biology Source Type: journals
Advances in mouse models of prostate cancer
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Review ArticlesImran Ahmad, Owen J. Sansom, Hing Y. Leung, Expert Reviews in Molecular Medicine, Volume 10 , pp e16AbstractAdvances in science and technology have allowed us to manipulate the mouse genome and analyse the effect of specific genetic alterations on the development of prostate cancer in vivo. We can now analyse the molecular basis of initiation, invasion and progression to metastatic disease. The current mouse models utilise knockout, knock-in or conditional regulation of expression using Cre hits PTENloxP/loxP mouse is the only model that spans the entire continuum from initiation to local invasion and metast...
Source: Expert Reviews in Molecular Medicine - July 4, 2008 Category: Molecular Biology Source Type: journals
Research highlights
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Nature Structural & Molecular Biology 15, 699 (2008). doi:10.1038/nsmb0708-699 (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - July 4, 2008 Category: Molecular Biology Tags: Research Highlights Source Type: journals
Bringing it together
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Nature Structural & Molecular Biology 15, 653 (2008). doi:10.1038/nsmb0708-653
An in-depth look at membrane fusion—a process essential for communication within and between cells—is presented in this issue of Nature Structural & Molecular Biology. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - July 4, 2008 Category: Molecular Biology Tags: Editorial Source Type: journals
Some classic papers in the field of membrane fusion—a personal view
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Some classic papers in the field of membrane fusion—a personal view
Nature Structural & Molecular Biology 15, 655 (2008). doi:10.1038/nsmb0708-655
Author: Reinhard Jahn
Every field of research has influential papers that have shaped and guided future work. Reinhard Jahn gives his picks for membrane fusion and a little bit of history about how the field has developed. (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - July 4, 2008 Category: Molecular Biology Authors: Reinhard Jahn Tags: Essay Source Type: journals
Ikk-2 is required for tnf-α-induced invasion and proliferation of human mesenchymal stem cells
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In conclusion, we demonstrated that the NF-κB pathway components, p65 and IKK-2, are expressed in hMSCs. Our data provide
evidence that this signal transduction pathway is implicated in TNF-α-mediated invasion and proliferation of hMSCs. Therefore,
hMSC recruitment to sites of tissue injury may, at least in part, be regulated by the NF-κB signal transduction pathway.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00109-008-0378-3Authors
Wolfgang Böcker, University of Munich (LMU) Experimental Surgery and Regenerative Medicine, Department of Surgery Nussbaumstrasse 20 80336 Munich GermanyDenits...
Source: Journal of Molecular Medicine - July 4, 2008 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals
Polymorphisms of the tumor necrosis factor-alpha (tnf) and the tnf-alpha converting enzyme (tace/adam17) genes in relation to cardiovascular mortality: the athero
gene
study
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Abstract Tumor necrosis factor (TNF) is a major cytokine involved in inflammatory reaction and a mortality predictor in patients with
coronary artery disease (CAD). Plasma levels of soluble TNF (sTNF) depend on the rate of its synthesis but also on its shedding
from cell surface, a mechanism mainly regulated by the TNF alpha converting enzyme (TACE or ADAM17). We investigated the relationship
between ADAM17 and TNF polymorphisms, circulating levels of shed ADAM17 substrates (sTNF, sTNFR1 and sTNFR2), and cardiovascular risk in a prospective
cohort of CAD patients. Five tag single-nucleotide polymorphisms (SN...
Source: Journal of Molecular Medicine - July 4, 2008 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals
Salmeterol with fluticasone enhances the suppression of il-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke
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In this study, the molecular mechanism behind the effectiveness of this combination therapy is investigated in human neutrophils.
Human neutrophils were preincubated with salmeterol or FP or the combination. The amount of interleukin-8 (IL-8), elastase
and matrix metalloproteinases (MMP)-2 and -9 releases, and reactive oxygen species (ROS) generation and expression of MAP
kinase phosphatase (MKP-1) and glucocorticoid receptor (GR) were determined. Cigarette smoke medium (CSM) induces an increased
expression of CXC receptors and the production of ROS that may explain the strong production of IL-8 by neutrophils. The exp...
Source: Journal of Molecular Medicine - July 4, 2008 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals
Critical immunological pathways are downregulated in apeced patient dendritic cells
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Abstract Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) is a monogenic autoimmune disease caused by mutations
in the autoimmune regulator (AIRE) gene. AIRE functions as a transcriptional regulator, and it has a central role in the development of immunological tolerance. AIRE
regulates the expression of ectopic antigens in epithelial cells of the thymic medulla and has been shown to participate in
the development of peripheral tolerance. However, the mechanism of action of AIRE has remained elusive. To further investigate
the role of AIRE in host immune functions, we studied the p...
Source: Journal of Molecular Medicine - July 4, 2008 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals
Interaction of chromium with resistant strain aspergillus versicolor: investigation with atomic force microscopy and other physical studies.
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Interaction of Chromium with Resistant Strain Aspergillus versicolor: Investigation with Atomic Force Microscopy and Other Physical Studies.
Langmuir. 2008 Jul 4;
Authors: Das SK, Mukherjee M, Guha AK
The interaction of chromium and a chromate resistant Aspergillus versicolor strain has been studied by atomic force (AFM) and transmission electron (TEM) microscopies. The nanomechanical properties such as cell wall rigidity and elasticity were measured by force spectroscopy and found to be 0.61 +/- 0.08 N/m, and 20.5 +/- 2.1 MPa, respectively. On chromium binding, ultrastuctural changes of the cell wall along wit...
Source: Cell Res - July 4, 2008 Category: Molecular Biology Authors: Das SK, Mukherjee M, Guha AK Tags: Langmuir Source Type: journals
Acute neonatal glucocorticoid exposure produces selective and rapid cerebellar neural progenitor cell apoptotic death
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mp; N B Farber (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - July 4, 2008 Category: Molecular Biology Authors: K K NoguchiK C WallsD F WozniakJ W OlneyK A RothN B Farber Source Type: journals
On the role of major vault protein in the resistance of senescent human diploid fibroblasts to apoptosis
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& S C Park (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - July 4, 2008 Category: Molecular Biology Authors: S J RyuH J AnY S OhH R ChoiM K HaS C Park Source Type: journals
Does autophagy have a license to kill mammalian cells?
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P Codogno (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - July 4, 2008 Category: Molecular Biology Authors: F ScarlattiR GranataA J MeijerP Codogno Source Type: journals
Transcriptomic analysis of saccharomyces cerevisiae physiology in the context of galactose assimilation perturbations
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C. Syriopoulos, A. Panayotarou, K. Lai, Maria I. Klapa
(Paper from Mol. BioSyst.)
C. Syriopoulos, Mol. BioSyst., 2008, DOI: 10.1039/b718732g
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - July 4, 2008 Category: Molecular Biology Authors: C. SyriopoulosA. Panayotarou K. Lai Maria I. Klapa Source Type: journals
Small molecule enhancers of autophagy for neurodegenerative diseases
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Sovan Sarkar, David C. Rubinsztein
(Highlight from Mol. BioSyst.)
Sovan Sarkar, Mol. BioSyst., 2008, DOI: 10.1039/b804606a
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - July 4, 2008 Category: Molecular Biology Authors: Sovan SarkarDavid C. Rubinsztein Source Type: journals
Biosensor recognition elements.
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PMID: 18525101 [PubMed - in process] (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Chambers JP, Arulanandam BP, Matta LL, Weis A, Valdes JJ Tags: Curr Issues Mol Biol Source Type: journals
Considerations in the development of live biotherapeutic products for clinical use.
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Discussion of considerations in the early development of LBPs may aid in preparation of an Investigational New Drug Application (IND) that is designed to collect clinical data to support marketing approval of a LBP in the U.S. for a specific clinical use. Product information is an important component of an IND to support a proposed clinical study.
PMID: 18525102 [PubMed - in process] (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Ross JJ, Boucher PE, Bhattacharyya SP, Kopecko DJ, Sutkowski EM, Rohan PJ, Chandler DK, Vaillancourt J Tags: Curr Issues Mol Biol Source Type: journals
Long-term stability of the human gut microbiota in two different rat strains.
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This study investigated the long-term stability of the bacterial community in such rats. Following the association of two strains of germ-free rats (12 male animals each) with fecal bacteria from a human donor the development of the microbiota was monitored for 12 months by PCR-denaturing gradient gel electrophoresis. During this time the Dice similarity coefficient (Cs) for the fecal microbial community of the rats associated with a human microbiota in comparison to the donor sample ranged between 73% +/- 8 and 74% +/- 3 for the Wistar and the Fischer 344 rats, respectively. After 12 months the similarity coefficients wer...
Source: Current Issues in Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Alpert C, Sczesny S, Gruhl B, Blaut M Tags: Curr Issues Mol Biol Source Type: journals
Gene-environment interactions and epigenetic basis of human diseases.
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Most human diseases are related in some way to the loss or gain in gene functions. Regulation of gene expression is a complex process. In addition to genetic mechanisms, epigenetic causes are gaining new perspectives in human diseases related to gene deregulation. Most eukaryotic genes are packed into chromatin structures, which lead to high condensations of the genes that require dynamic chromatin remodeling processes to facilitate their transcription. DNA methylation and histone modifications represent two of the major chromatin remodeling processes. They also serve to integrate environmental signals for the cells to...
Source: Current Issues in Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Liu L, Li Y, Tollefsbol TO Tags: Curr Issues Mol Biol Source Type: journals
Immunomodulatory effects of probiotics in the intestinal tract.
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The intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. The interaction between probiotic and enterocytes is the initiating event in immunomodulation and merits particular attention. The effects of probiotic is strain dependent and for each new probiotic strain, profiles of cytokines secreted by lymphocytes, enterocytes or dendritic cells that come in contact with the strain should be systematically established. To evaluate the effects of probiotics on the immune system, models that mimic the mucosa, and thus the physiological reality, sh...
Source: Current Issues in Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Delcenserie V, Martel D, Lamoureux M, Amiot J, Boutin Y, Roy D Tags: Curr Issues Mol Biol Source Type: journals
Gene amplification from cryopreserved arabidopsis thaliana shoot tips.
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Gene amplification from cryopreserved Arabidopsis thaliana shoot tips.
Curr Issues Mol Biol. 2008;10(1-2):55-60
Authors: Basu C
Cryopreservation is a way to store elite quality plant germplasms. The exact mechanism of stress tolerance during cryopreservation is unknown. Unavavailability of a detailed protocol for understanding the molecular genetics of plant cryostress is a major obstacle in plant cryobiology research. This paper describes the methods of extraction of total RNA from cryogenically stored plant tissues accompanied by successful amplication of cDNAs by reverse transcriptase PCR. The whole process ...
Source: Current Issues in Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Basu C Tags: Curr Issues Mol Biol Source Type: journals
The eph receptor/ephrin system: an emerging player in the invasion game.
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The Eph receptor/ephrin system: an emerging player in the invasion game.
Curr Issues Mol Biol. 2008;10(1-2):61-6
Authors: Campbell TN, Robbins SM
Eph receptor tyrosine kinases (Ephs) and their membrane-anchored ligands (ephrins) form a vital cell communication system capable of bi-directional signaling. This Eph receptor/ephrin system has classically been demonstrated to play a role in development. However, emerging evidence has revealed differential expression of Ephs and ephrins in numerous cancers. Recent studies suggest that this system influences invasive behaviour, promoting a more aggressive and metastat...
Source: Current Issues in Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Campbell TN, Robbins SM Tags: Curr Issues Mol Biol Source Type: journals
Growth factor effects on costal chondrocytes for tissue engineering fibrocartilage
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This study employed five growth factors (insulin-like growth factor-I, transforming growth factor-β1, epidermal
growth factor, platelet-derived growth factor-BB, and basic fibroblast growth factor) in a scaffoldless approach with costal
chondrocytes, attempting to improve biochemical and mechanical properties of engineered constructs. Samples were quantitatively
assessed for total collagen, glycosaminoglycans, collagen type I, collagen type II, cells, compressive properties, and tensile
properties at two time points. Most treated constructs had lower biomechanical and biochemical properties than the controls
with no ...
Source: Cell and Tissue Research - July 3, 2008 Category: Molecular Biology Tags: Cell and Tissue Research Source Type: journals
Upregulation of cathepsin b expression and enhanced secretion in mitochondrial dna-depleted osteosarcoma cells.
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Conclusions. The upregulation of cathepsin B by NFkappaB, followed by its secretion into the extracellular environment, might be partly responsible for the previously reported invasiveness of the mtDNA-depleted 143B osteosarcoma cells.
PMID: 18598236 [PubMed - as supplied by publisher] (Source: Biology of the Cell)
Source: Biology of the Cell - July 3, 2008 Category: Molecular Biology Authors: Hamer I, Delaive E, Dieu M, Abdel-Sater F, Mercy L, Jadot M, Arnould T Tags: Biol Cell Source Type: journals
Raman microspectrometry sulphur detection and characterisation in the marine ectosymbiotic nematode eubostrichus dianae (desmodoridae, stilbonematidae).
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Conclusions As Raman Spectrometry can be used on living organisms (without preliminary fixation) without sample damages and preserving the molecular structure of the sulphur (denatured during chemical fixation) it represents a very well adapted investigation tool for biologists. This technique permits therefore to detect quickly and easily (in few seconds and on entire living animals) the presence of sulphur compounds in the symbiotic nematode.
PMID: 18598237 [PubMed - as supplied by publisher] (Source: Biology of the Cell)
Source: Biology of the Cell - July 3, 2008 Category: Molecular Biology Authors: Himmel D, Maurin LC, Gros O, Mansot JL Tags: Biol Cell Source Type: journals
Protective effects of epigallocatechin gallate on colon preneoplastic lesion induced by 2-amino-3-methylimidazo [4, 5-f] quinoline in mice.
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In conclusion, EGCG had preventive effects on preneoplastic lesion induced by IQ. Ourobservations suggest that this effect may be the result of activation of the Nrf2-UGT1A10 signaling pathway.
PMID: 18596869 [PubMed - as supplied by publisher] (Source: Molecular Medicine)
Source: Molecular Medicine - July 3, 2008 Category: Molecular Biology Authors: Yuan JH, Li YQ, Yang XY Tags: Mol Med Source Type: journals
Identification of marker genes for differential diagnosis of chronic fatigue syndrome.
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Identification of Marker Genes for Differential Diagnosis of Chronic Fatigue Syndrome.
Mol Med. 2008 Jul 3;
Authors: Saiki T, Kawai T, Morita K, Ohta M, Saito T, Rokutan K, Ban N
Chronic fatigue syndrome (CFS) is a clinically defined condition characterized by long-lasting disabling fatigue. Because of the unknown mechanism underlying this syndrome, there is still no specific biomarker for objective assessment of the pathological fatigue. We have compared gene expression profiles in peripheral blood between 11 drug-free patients with CFS and age- and sex-matched healthy subjects using a custom microarray carryi...
Source: Molecular Medicine - July 3, 2008 Category: Molecular Biology Authors: Saiki T, Kawai T, Morita K, Ohta M, Saito T, Rokutan K, Ban N Tags: Mol Med Source Type: journals
Membrane fusion
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hekman (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: William WicknerRandy Schekman Tags: Review Source Type: journals
Synaptic vesicle fusion
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enmund (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Josep RizoChristian Rosenmund Tags: Review Source Type: journals
The fusion pores of ca2+-triggered exocytosis
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The fusion pores of Ca2+-triggered exocytosis
Nature Structural & Molecular Biology 15, 684 (2008). doi:10.1038/nsmb.1449
Authors: Meyer B Jackson
& Edwin R Chapman (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Meyer B JacksonEdwin R Chapman Tags: Review Source Type: journals
Viral membrane fusion
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Nature Structural & Molecular Biology 15, 690 (2008). doi:10.1038/nsmb.1456
Author: Stephen C Harrison (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Stephen C Harrison Tags: Review Source Type: journals
Mechanics of membrane fusion
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Kozlov (Source: Nature Structural and Molecular Biology)
Source: Nature Structural and Molecular Biology - July 3, 2008 Category: Molecular Biology Authors: Leonid V ChernomordikMichael M Kozlov Tags: Review Source Type: journals
The palladium-catalysed copper-free sonogashira coupling of isoindoline nitroxides: a convenient route to robust profluorescent carbon-carbon frameworks
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Daniel J. Keddie, Kathryn E. Fairfull-Smith, Steven E. Bottle
(Paper from Org. Biomol. Chem.)
Daniel J. Keddie, Org. Biomol. Chem., 2008, DOI: 10.1039/b806963h
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The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - July 3, 2008 Category: Molecular Biology Authors: Daniel J. KeddieKathryn E. Fairfull-Smith Steven E. Bottle Source Type: journals
Polar [3 + 2] cycloaddition of ketones with electrophilically activated carbonyl ylides. synthesis of spirocyclic dioxolane indolinones
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Ghenia Bentabed-Ababsa, Aicha Derdour, Thierry Roisnel, Jose A. Saez, Luis R. Domingo, Florence Mongin
(Paper from Org. Biomol. Chem.)
Ghenia Bentabed-Ababsa, Org. Biomol. Chem., 2008, DOI: 10.1039/b804856h
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - July 3, 2008 Category: Molecular Biology Authors: Ghenia Bentabed-AbabsaAicha Derdour Thierry Roisnel Jose A. Saez Luis R. Domingo Florence Mongin Source Type: journals
Generation of molecular diversity using a complexity-generating mcr-platform towards triazinane diones
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Bas Groenendaal, Eelco Ruijter, Frans J. J. de Kanter, Martin Lutz, Anthony L. Spek, Romano V. A. Orru
(Paper from Org. Biomol. Chem.)
Bas Groenendaal, Org. Biomol. Chem., 2008, DOI: 10.1039/b807138a
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - July 3, 2008 Category: Molecular Biology Authors: Bas GroenendaalEelco Ruijter Frans J. J. de Kanter Martin Lutz Anthony L. Spek Romano V. A. Orru Source Type: journals
Analysis of systemic sulfur metabolism in plants using integrated '-omics' strategies
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Masami Yokota Hirai, Kazuki Saito
(Highlight from Mol. BioSyst.)
Masami Yokota Hirai, Mol. BioSyst., 2008, DOI: 10.1039/b802911n
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - July 3, 2008 Category: Molecular Biology Authors: Masami Yokota HiraiKazuki Saito Source Type: journals
Involvement of jnk regulation in oxidative stress-mediated murine liver injury by microcystin-lr
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Abstract Microcystin-LR (MC-LR) produced by cyanobacteria in diverse water systems is a potent specific hepatotoxin and has been documented
to induce various liver diseases via oxidative stress. However, the underlying mechanisms are largely unknown. In the current
study, we investigated the molecular events involved in the oxidative liver injury by MC-LR. Our results demonstrated that
MC-LR induced liver injury in mice through a series of steps that began with the production of reactive oxygen species (ROS),
which stimulated the sustained activation of JNK and its downstream targets, AP-1 and Bid. Furthermo...
Source: Apoptosis - July 2, 2008 Category: Molecular Biology Tags: Apoptosis Source Type: journals
Erratum
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Nature Cell Biology 10, 874 (2008). doi:10.1038/ncb0708-874 (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 2, 2008 Category: Molecular Biology Tags: Erratum Source Type: journals
Research highlights
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Nature Cell Biology 10, 764 (2008). doi:10.1038/ncb0708-764 (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 2, 2008 Category: Molecular Biology Tags: Research Highlights Source Type: journals
Signalling links
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Nature Cell Biology 10, 753 (2008). doi:10.1038/ncb0708-753b
Our papers now link directly to relevant Molecule Page database entries at the Signaling Gateway (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 2, 2008 Category: Molecular Biology Tags: Editorial Source Type: journals
Birthday precedings
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Nature Cell Biology 10, 753 (2008). doi:10.1038/ncb0708-753a
As some of the new 'web 2.0'-enabled publishing ventures mature, we take stock of their utility to the community (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 2, 2008 Category: Molecular Biology Tags: Editorial Source Type: journals
Opposing roles for glypicans in hedgehog signalling
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Opposing roles for glypicans in Hedgehog signalling
Nature Cell Biology 10, 761 (2008). doi:10.1038/ncb0708-761
Authors: Dong Yan
& Xinhua Lin
Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite effects of glypicans on Hedgehog signalling and show how their core protein domains and GPI anchor contribute to their versatile biological functions. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 2, 2008 Category: Molecular Biology Authors: Dong YanXinhua Lin Tags: News and Views Source Type: journals
Cdh1: a master g0/g1 regulator
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Cdh1: a master G0/G1 regulator
Nature Cell Biology 10, 755 (2008). doi:10.1038/ncb0708-755
Authors: Jeffrey R. Skaar
& Michele Pagano
APC/CCdh1 controls the G0 and G1 phases of the cell cycle. Using a conditional knockout of the Cdh1 coding gene Fizzy-related (Fzr), a new study demonstrates that Cdh1 is essential for viability and that it functions as a tumour suppressor by preventing genomic instability. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 2, 2008 Category: Molecular Biology Authors: Jeffrey R. SkaarMichele Pagano Tags: News and Views Source Type: journals
Uvrag reveals its second nature
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UVRAG reveals its second nature
Nature Cell Biology 10, 759 (2008). doi:10.1038/ncb0708-759
Authors: Karolina Peplowska, Margarita Cabrera
& Christian Ungermann
UVRAG, a known regulator of autophagosome formation, also promotes autophagosome maturation by recruiting the fusion machinery of the late endosome. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 2, 2008 Category: Molecular Biology Authors: Karolina PeplowskaMargarita CabreraChristian Ungermann Tags: News and Views Source Type: journals
Breaking down emt
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Breaking down EMT
Nature Cell Biology 10, 757 (2008). doi:10.1038/ncb0708-757
Authors: Romain Levayer
& Thomas Lecuit
Epithelial–mesenchymal transition, in which epithelial cells lose their polarity and become motile mesenchymal cells, occurs during development and marks a key step in tumour progression towards metastasis. Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway involving RhoA and microtubules may be equally important. (Source: Nature Cell Biology)
Source: Nature Cell Biology - July 2, 2008 Category: Molecular Biology Authors: Romain LevayerThomas Lecuit Tags: News and Views Source Type: journals
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
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Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span.
Cell Metab. 2008 Jul 2;
Authors: Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R
A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and o...
Source: Cell Metabolism - July 2, 2008 Category: Molecular Biology Authors: Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf N Tags: Cell Metab Source Type: journals
Large-scale quantitative lc-ms/ms analysis of detergent-resistant membrane proteins from rat renal collecting duct.
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Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct.
Am J Physiol Cell Physiol. 2008 Jul 2;
Authors: Yu MJ, Pisitkun T, Wang G, Aranda JF, Gonzales PA, Tchapyjnikov D, Shen RF, Alonso MA, Knepper MA
In the renal collecting duct, vasopressin controls transport of water and solutes via regulation of membrane transporters such as aquaporin-2 (AQP2) and the epithelial urea transporter, UT-A. To discover proteins potentially involved in vasopressin action in rat kidney collecting ducts, membrane "raft" proteins were enriched by harvesting detergent-resis...
Source: Am J Physiol Cell Ph... - July 2, 2008 Category: Molecular Biology Authors: Yu MJ, Pisitkun T, Wang G, Aranda JF, Gonzales PA, Tchapyjnikov D, Shen RF, Alonso MA, Knepper MA Tags: Am J Physiol Cell Physiol Source Type: journals
Connective tissue growth factor inhibits adipocyte differentiation.
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Adipocyte differentiation is a key process implicated in the pathogenesis of obesity and insulin resistance. Its regulation is triggered by a cascade of transcription factors, including the CCAAT/enhancer binding proteins (C/EBPs) and PPARgamma. Growth factors such as transforming growth factor-beta1 (TGF-beta1) are known to inhibit adipocyte differentiation in vitro via the C/EBP pathway, and in vivo, but whether a downstream mediator of TGF-beta1, connective tissue growth factor (CTGF) also known as CCN2, has a similar role, is unknown. Mouse 3T3-L1 cells were differentiated into adipocytes using standard methods and...
Source: Am J Physiol Cell Ph... - July 2, 2008 Category: Molecular Biology Authors: Tan JT, McLennan SV, Song WW, Lo LW, Bonner JG, Williams PF, Twigg SM Tags: Am J Physiol Cell Physiol Source Type: journals
