Molecular Biology 
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82146 records returned
The dependence of [small alpha]-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06612B, PaperPatrice Morliere, Larry K. Patterson, Clementina M. M. Santos, Artur M. S. Silva, Jean-Claude Maziere, Paulo Filipe, Ana Gomes, Eduarda Fernandes, M. Beatriz Q. Garcia, Rene SantusFour hydroxyl groups are required for the repair of [small alpha]-tocopheroxyl radical by hydroxy-2,3-diarylxanthones.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Patrice Morliere Source Type: research
Synthesis of pyrrolyldipyrrinato BF2 complexes by oxidative nucleophilic substitution of boron dipyrromethene with pyrroleEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06689K, PaperMin Zhang, Erhong Hao, Jinyuan Zhou, Changjiang Yu, Guifeng Bai, Fengyun Wang, Lijuan JiaoPyrrolyldipyrrinato BF2 complexes have been synthesized via a direct oxidative nucleophilic substitution of the 3-hydrogen of BODIPY dyes by pyrrole.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Min Zhang Source Type: research
Involvement of DNA binding domain in the cellular stability and importin affinity of NF-[small kappa]B component RelBEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07104E, PaperMasatoshi Takeiri, Kana Horie, Daisuke Takahashi, Mariko Watanabe, Ryoichi Horie, Siro Simizu, Kazuo UmezawaNF-[small kappa]B is a transcription factor for the immune activation and tissue stability, but excess activation of NF-[small kappa]B often causes inflammation and cancer. An NF-[small kappa]B component RelB is involved in B-cell...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Masatoshi Takeiri Source Type: research
Synthesis and Protein Binding Studies of a Peptide Fragment of Clathrin Assembly Protein AP180 Bearing an O-Linked b-N-Acetylglucosaminyl-6-phosphate ModificationEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07139H, CommunicationRichard James Payne, Mark E Graham, Robin S Stone, Phillip J RobinsonA novel post-translational modification of threonine, b-N-acetylglucosaminyl-phosphate, was recently discovered on assembly protein AP180, a protein which plays a crucial role in clathrin coated vesicle formation in synaptic vesicle endocytosis...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Richard James Payne Source Type: research
Fused Ring Aziridines as a Facile Entry into Triazole Fused Tricyclic and Bicyclic HeterocyclesEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07042A, PaperFang Fang, Megan Vogel, Jennifer V Hines, Stephen BergmeierThe intramolecular dipolar cycloaddition of an azide with an alkyne has provided a useful entry into triazole fused tricyclic heterocycles containing both the triazole ring and the oxazolidin-2-one ring system....The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Fang Fang Source Type: research
Click Synthesized Dianthryl-TTFV: An Efficient Fluorescent Turn-On Probe for Transition Metal IonsEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB06828A, CommunicationKarimulla Mulla, Prateek Dongare, David W Thompson, Yuming ZhaoTetrathiafulvalene vinylogue (TTFV) was functionalized with two anthryl fluorophores via Cu(I)-catalyzed alkyne-azide [3+2] cycloaddition, forming a dianthryl-TTFV hybrid to show fluorescent turn-on sensing behaviour for Cu2+, Fe2+, and Cd2+ ions...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Karimulla Mulla Source Type: research
A nmr and computational study of smac mimics targeting both the bir2 and bir3 domains in xiap proteinEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB06979B, PaperDonatella Potenza, laura BelvisiIn this paper we report an extensive NMR analysis of small ligands (Smac mimics) complexed with different constructs of XIAP. The mimics-binding site of XIAP is known as the BIR3...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Donatella Potenza Source Type: research
Tetrakis(methylimidazole) and tetrakis(methylimidazolium) calix[4]arenes: competitive anion binding and deprotonationEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07025A, PaperCharlotte E. Willans, Emma K Bullough, Marc A Little, Colin KilnerNeutral tetrakis(methylimidazole) (1) and the novel cationic tetrakis(methylimidazolium) (2) calixarenes have been prepared and their solid-state and solution behaviour examined. The neutral imidazole forms a mono-zwitterion at elevated temperature, a...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Charlotte E. Willans Source Type: research
A Computational Study of the Enantioselective Addition of n-BuLi to Benzaldehyde in the Presence of a Chiral Lithium N,P-AmideEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB06910E, PaperSten O. Nilsson Lill, Per-Ola Norrby, Jurgen Grafenstein, Goran Hilmersson, Petra RonnholmIn the presence of a chiral lithium N,P amide, alkylation of benzaldehyde results in an enantioselective formation of 1-phenyl-pentanol. This stereoselective addition reaction has herein been studied using dispersion-corrected density...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Sten O. Nilsson Lill Source Type: research
Intramolecular Chiral Communication in Peptide-Dendron HybridsEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07014F, CommunicationHui Shao, Nicholas A Bewick, Jon ParquetteThe conformational properties of a series of peptide-dendron hybrids progressively incorporating 1-4 dendritic side chains were investigated by circular dichroism. Although the presence of multiple adjacent dendrons along the peptide...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Hui Shao Source Type: research
Solid-state supramolecular assemblies consisting of planar charged speciesEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07059F, PaperYohei Haketa, Mayumi Takayama, Hiromitsu MaedaPyrrole-based [small pi]-conjugated anion-responsive molecules provided various planar anionic structures by complexation with halide anions, resulting in the formation of solid-state assemblies with planar counter cations and exhibiting various modes of...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 6, 2012 Category: Molecular Biology Authors: Yohei Haketa Source Type: research
GENOCOP algorithm and hierarchical grid transformation for image warping of two dimensional gel eletrophoretic mapsEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05396A, PaperEmilio Marengo, Marina Cocchi, Marco Demartini, Elisa Robotti, Daniela Cecconi, Giorgio CalabreseHierarchical grid transformation is a powerful approach to SDS 2DPAGE maps warping. The numerical optimization of the warping procedure is a multivariate task that can be solved efficiently using Genetic algorithms for Numerical Optimization in COnstrained Problems (GENOCOP).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 6, 2012 Category: Molecular Biology Authors: Emilio Marengo Source Type: research
Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell diseaseEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05461B, PaperNing Sun, Jing Liang, Zhanar Abil, Huimin ZhaoThe first pair of TAL effector nucleases was created and optimized for efficient cleavage of human [small beta]-globin gene locus, which may be used in treatment of sickle cell disease.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 6, 2012 Category: Molecular Biology Authors: Ning Sun Source Type: research
Genetic screens for the control of influenza virus replication: from meta-analysis to drug discoveryEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05416G, PaperBenoit de Chassey, Laurene Meyniel-Schicklin, Anne Aublin-Gex, Patrice Andre, Vincent LotteauIntegration of genetic screens and protein interaction data provides a rationale to identify drug candidates against influenza virus.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 6, 2012 Category: Molecular Biology Authors: Benoit de Chassey Source Type: research
Parallel Tracking of cAMP and PKA signaling dynamics in Living Cells with FRET-based Fluorescent BiosensorsEmail this article to a colleague.
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Mol. BioSyst., 2012, Accepted ManuscriptDOI: 10.1039/C2MB05514G, PaperNwe-Nwe Aye-Han, Michael D. Allen, Qiang Ni, Jin ZhangProper regulation of cellular functions relies upon a network of intricately interwoven signaling cascades in which multiple components must be tightly coordinated both spatially and temporally. To better understand how...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 6, 2012 Category: Molecular Biology Authors: Nwe-Nwe Aye-Han Source Type: research
Identification of DNA-protein complexes using an improved, combined Western Blotting- Electrophoretic Mobility Shift Assay (EMSA) with a fluorescence imaging systemEmail this article to a colleague.
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Mol. BioSyst., 2012, Accepted ManuscriptDOI: 10.1039/C2MB05500G, MethodKlaus Deckmann, Florian Rorsch, Gerd Geisslinger, Sabine GroschElectrophoretic Mobility Shift Assays (EMSAs) are used to detect DNA-protein interactions. With this type of assay it is difficult to distinguish between specific and non-specific DNA-protein complexes or to define...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 6, 2012 Category: Molecular Biology Authors: Klaus Deckmann Source Type: research
Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanateEmail this article to a colleague.
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This study represents the first use of RNAseq to analyze tumors from animals consuming dietary phenethyl isothiocyanate and to identify potential molecular signatures that may explain the cancer protective effect of this compound. © 2012 Wiley Periodicals, Inc. (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - February 6, 2012 Category: Molecular Biology Authors: Robert W. LiCongJun LiThomas T.Y. Wang Tags: Research Article Source Type: research
The Molecular Mechanisms of the Hepatoprotective Effect of Gomisin A against Oxidative Stress and Inflammatory Response in Rats with Carbon Tetrachloride-Induced Acute Liver Injury.Email this article to a colleague.
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Abstract
Oxidative damage and inflammation are implicated in the pathogenesis of liver injury and fibrosis. In the present study, we investigated the molecular mechanism by which gomisin A conferred a hepatoprotective effect, focusing on its antioxidant and anti-inflammatory effects using rats with carbon tetrachloride (CCl(4))-induced acute liver injury. Pretreatment with gomisin A prior to the administration of CCl(4) markedly prevented an increase in alanine aminotransferase, aspartate aminotransferase, and histological hepatic lesions. Gomisin A was also associated with a decrease in hepatic lipid peroxidation,...
Source: Biological and Pharmaceutical Bulletin - February 6, 2012 Category: Drugs & Pharmacology Authors: Teraoka R, Shimada T, Aburada M Tags: Biol Pharm Bull Source Type: research
High rates of de novo 15q11q13 inversions in human spermatozoaEmail this article to a colleague.
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Low-Copy Repeats predispose the 15q11-q13 region to non-allelic homologous recombination. We have already demonstrated that a significant percentage of Prader-Willi syndrome (PWS) fathers have an increased susceptibility to generate 15q11q13 deletions in spermatozoa, suggesting the participation of intrachromatid exchanges. This work has been focused on assessing the incidence of de novo 15q11q13 inversions in spermatozoa of control donors and PWS fathers in order to determine the basal rates of inversions and to confirm the intrachromatid mechanism as the main cause of 15q11q13 anomalies.Semen samples from 10 control dono...
Source: Molecular Cytogenetics - February 6, 2012 Category: Molecular Biology Authors: Oscar MolinaEster AntonFrancesca VidalJoan Blanco Source Type: research
Enumerating metabolic pathways for the production of heterologous target chemicals in chassis organismsEmail this article to a colleague.
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Conclusions:
We find the topological approach to be faster by several orders of magnitude than the steady state approach. Yet both methods are generally scalable in time with the number of pathways in the metabolic network. Therefore this work provides an efficient tool for pathway enumeration with direct application to biosynthetic pathway design. (Source: BMC Systems Biology - Latest articles)
Source: BMC Systems Biology - Latest articles - February 6, 2012 Category: Molecular Biology Authors: Pablo CarbonellDavide FicheraShashi PanditJean-Loup Faulon Source Type: research
Acoustic structure of male loud-calls support molecular phylogeny of Sumatran and Javanese leaf monkeys (genus Presbytis)Email this article to a colleague.
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Conclusions:
In this study we show, that as in crested gibbons, the acoustic structure of surili loud-calls is a reliable tool to distinguish between species and to verify phylogenetic relatedness and migration backgrounds of respective taxa. Since vocal production in other nonhuman primates show similar constraints, it is likely that an acoustic analysis of call structure can help to clarify taxonomic and phylogenetic relationships. (Source: BMC Evolutionary Biology - Latest articles)
Source: BMC Evolutionary Biology - Latest articles - February 6, 2012 Category: Molecular Biology Authors: Dirk MeyerJohn HodgesDones RinaldiAmbang WijayaChristian RoosKurt Hammerschmidt Source Type: research
Heart hormone helps shape fat metabolismEmail this article to a colleague.
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This study increases our understanding of fat tissue regulation and may lead to new therapies aimed at weight reduction. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 6, 2012 Category: Biology Source Type: news
A new species of bamboo-feeding plant lice found in Costa RicaEmail this article to a colleague.
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(Pensoft Publishers) Several periods of field work during 2008 have led to the discovery of a new species of bamboo-feeding plant lice in Costa Rica's high-altitude region Cerro de la Muerte. The discovery was made thanks to molecular data analysis of mitochondrial DNA. The collected records have also increased the overall knowledge of plant lice (one of the most dangerous agricultural pests worldwide) from the region with more that 20 percent. The study was published in the open-access journal ZooKeys. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 6, 2012 Category: Biology Source Type: news
Personalized therapy of lung cancer.Email this article to a colleague.
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Abstract
The implementation of personalized approaches in the treatment of patients with non-small cell lung cancer (NSCLC) requires a precise understanding of tumor biology, a reorientation of clinical development with a strong focus on genetically stratified early phase 'proof of concept' trials, the availability of high-quality 'realtime' genetic diagnostics, and the establishment of networks for molecular screening of lung cancer patients. To achieve this goal, a close interaction between basic researchers, clinical scientists, molecular pathologists, and pharmaceutical companies is essential. We believe that t...
Source: Onkologie - February 5, 2012 Category: Cancer & Oncology Authors: Thomas R, Wolf J Tags: Onkologie Source Type: research
Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes.Email this article to a colleague.
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Abstract
OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: Autoinflammatory syndromes are disorders characterized by the hyperactivation of the innate immune system in the absence of microbial infection or autoantibody production. Some autoinflammatory syndromes are associated with recurrent episodes of fever and systemic inflammation that are caused by dysregulated activation of inflammasomes, molecular platforms responsible for the activation of caspase-1 and the production of interleukin (IL)-1β. In th...
Source: Clinical and Developmental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: Ozkurede VU, Franchi L Tags: Clin Exp Immunol Source Type: research
Molecular Biology of Diabetes, Part IIEmail this article to a colleague.
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Insulin Action, Effects on Gene Expression and Regulation, and Glucose TransportThese comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake. (Source: Springer Medicine titles)
Source: Springer Medicine titles - February 5, 2012 Category: Databases & Libraries Tags: Endocrinology Source Type: news
Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR‐17‐92 clusterEmail this article to a colleague.
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This study examined the role of microRNAs (miRNAs) in mediating the chemo‐protective effects of HDIs, and explored functions of the oncogenic miR‐17‐92 cluster. The dysregulated miRNA expression observed in HT29 and HCT116 CRC cells could be epigenetically altered by butyrate, SAHA and TSA. These HDIs decreased expression of miR‐17‐92 cluster miRNAs (P < 0.05), with a corresponding increase in miR‐17‐92 target genes, including PTEN, BCL2L11, and CDKN1A (P < 0.05). The decrease in miR‐17‐92 expression may be partly responsible for the anti‐proliferative effects of HDIs, with introduction of...
Source: Molecular Carcinogenesis - February 5, 2012 Category: Molecular Biology Authors: Karen J. HumphreysLynne CobiacRichard K. Le LeuMark B. Van der HoekMichael Z. Michael Tags: Research Article Source Type: research
Synthesis of amine-functionalized heparin oligosaccharides for the investigation of carbohydrate-protein interactions in microtiter platesEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06607F, PaperSusana Maza, Giuseppe Macchione, Rafael Ojeda, Javier Lopez-Prados, Jesus Angulo, Jose L. de Paz, Pedro M. NietoA series of amine-functionalized heparin oligosaccharides were efficiently synthesized and attached to microplates for the qualitative and quantitative analysis of their interactions with proteins.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Susana Maza Source Type: research
N-Activated [small beta]-lactams as versatile reagents for acyl carrier protein labelingEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06846J, PaperGitanjeli Prasad, Jon W. Amoroso, Lawrence S. Borketey, Nathan A. SchnarrA series of reactive [small beta]-lactams have been prepared for direct labeling of holo-acyl carrier proteins in site-selective fashion.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Gitanjeli Prasad Source Type: research
A New Synthetic Route for Axially Chiral Secondary Amines with Binaphthyl Backbone and Their Applications in Asymmetric Michael Reaction of Aldehydes to NitroalkenesEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07110J, PaperDa-Cheng Liang, Ren-Shi Luo, Li-Hua Yin, Albert S. C. Chan, Gui LuA new synthetic route for binaphthyl-based secondary amines has been developed. The key feature of this route includes the selective direct esterification of the binaphthyl structure at the 3- or...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Da-Cheng Liang Source Type: research
A General Electron Transfer Reduction of Lactones Using SmI2-H2OEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB00017B, CommunicationMichal Szostak, Karl D Collins, Neal J Fazakerley, Malcolm Spain, David John ProcterHerein we describe a strategy for the selective, electron transfer reduction of lactones of all ring sizes and topologies using SmI2-H2O and a Lewis base to tune the redox properties...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Michal Szostak Source Type: research
Investigating the Reaction Mechanism and Organocatalytic Synthesis of [small alpha],[small alpha]'-Dihydroxy KetonesEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB06939C, PaperHelen Hailes, James L Galman, David Steadman, Lisa D HaighA biomimetic TK one-pot reaction using hydroxypyruvate and aldehydes to generate [small alpha],[small alpha]'-dihydroxy ketones in water has recently been described. To investigate this tertiary-amine mediated reaction mechanism two approaches were used....The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Helen Hailes Source Type: research
Mechanism of the alkali degradation of (6-4) photoproduct-containing DNAEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06966K, PaperNorihito Arichi, Aki Inase, Sachise Eto, Toshimi Mizukoshi, Junpei Yamamoto, Shigenori IwaiThe mechanism of the alkali-induced strand breaks caused at the (6-4) photoproduct sites in UV-irradiated DNA was elucidated.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Norihito Arichi Source Type: research
Lipothiophosphoramidates for gene delivery: critical role of the cationic polar headgroupEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06812E, PaperAurore Fraix, Tristan Montier, Tony Le Gall, Charlotte M. Sevrain, Nathalie Carmoy, Mattias F. Lindberg, Pierre Lehn, Paul-Alain JaffresThe synthesis of cationic lipothiophosphoramidates possessing different cationic groups (ammonium, phosphonium or arsonium) is reported. Transfection experiments showed that the arsonium-containing lipid (Z+ = As+) is globally the most efficient on the three cell lines tested.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Ch...
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Aurore Fraix Source Type: research
Studies on a novel class of triaryl pyridine N-glycosylamine amphiphiles as super gelatorsEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06834F, PaperManivannan Kalavathi Dhinakaran, Thangamuthu Mohan DasA novel class of six different triaryl pyridine N-glycosylamine amphiphiles was synthesised and characterized based on different spectral techniques, such as NMR and mass analysis. Gelation was observed predominantly in aliphatic solvents and is due to the presence of the alkyl chain. All the gels thus obtained were studied using powder XRD and FE-SEM techniques which reveal fibrous entanglement of the molecules in the gel state.To cite this article before page numbers are assigned, use the DOI form ...
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Manivannan Kalavathi Dhinakaran Source Type: research
The microbial cell factoryEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06903B, PerspectiveCormac D. MurphyMicroorganisms are involved in many applications; this review outlines some of the contemporary products arising from manipulation of bacteria and fungi.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Cormac D. Murphy Source Type: research
Insights into a surprising reaction: The microwave-assisted direct esterification of phosphinic acidsEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06972E, PaperGyorgy Keglevich, Nora Zsuzsa Kiss, Zoltan Mucsi, Tamas KortvelyesiNew synthetic results and theoretical data including the thermodynamic and kinetic parameters are discussed for the direct esterification of phosphinic acids that is reluctant on heating, but takes place quantitatively on MW irradiation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Gyorgy Keglevich Source Type: research
Fluorogenic sensing of CH3CO2- and H2PO4- by ditopic receptor through conformational changeEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06994F, PaperNisar Ahmed, Vangaru Suresh, Bahareh Shirinfar, Inacrist Geronimo, Amita Bist, In-Chul Hwang, Kwang S. KimCyclo-bis-(urea-3,6-dichlorocarbazole) (1) forms a 1 : 2 complex with CH3CO2- and H2PO4- through hydrogen bonding with the two urea moieties, resulting in fluorescence enhancement via a combined photoinduced electron transfer (PET) and energy transfer mechanism.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Nisar Ahmed Source Type: research
Relaxation of the rigid backbone of an oligoamide-foldamer-based [small alpha]-helix mimetic: identification of potent Bcl-xL inhibitorsEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07125H, CommunicationJeremy Yap, Xiaobo Cao, Kenno Vanommeslaeghe, Kwan-Young Jung, Paul Wilder, anjan nan, Alex Mackerell, W Roy Smythe, Steven FletcherBy conducting a structure-activity relationship study of the backbone of a series of oligoamide-foldamer-based [small alpha]-helix mimetics of the Bak BH3 helix, we have identified especially potent inhibitors of Bcl-xL. The...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Jeremy Yap Source Type: research
Using Light and a Molecular Switch to 'Lock' and 'Unlock" the Diels-Alder ReactionEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB06908C, PaperZach Erno, Amir AsadiRad, Vincent Lemieux, Neil R. BrandaLight is used to 'gate' the Diels-Alder reaction using a photoresponsive dithienylfuran backbone and turn the reversibility of the Diels-Alder reaction 'off' and 'on' at 100 [degree]C. These features make...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Zach Erno Source Type: research
Copper(I) Acetate-Catalyzed Azide-Alkyne Cycloaddition for Highly Efficient Preparation of 1-(Pyridin-2-yl)-1,2,3-TriazolesEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB06942C, PaperQun Zhang, Xinyan Wang, Chuanjie Cheng, Rui Zhu, Nan Liu, Yuefei HuA highly efficient copper(I)-catalyzed azide-alkyne cycloaddition of 6-NO2 and 6-CO2Et substituted tetrazolo[1,5-a]pyridines was developed for the preparation of 1-(pyridin-2-yl)-1,2,3-triazoles by simply using copper(I) acetate as a catalyst. The in situ...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Qun Zhang Source Type: research
Efficient synthesis of carbazoles via PtCl2-catalyzed RT cyclization of 1-(indol-2-yl)-2,3-allenols: scope and mechanismEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C1OB06474F, PaperWangqing Kong, Chunling Fu, Shengming MaThe efficient PtCl2-catalyzed synthesis of carbazoles from 1-(indol-2-yl)-2,3-allenols through a unique metal carbene intermediate is described.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Wangqing Kong Source Type: research
2-Aminopyrimidine as a novel scaffold for biofilm modulationEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06871K, PaperErick A. Lindsey, Roberta J. Worthington, Cristina Alcaraz, Christian MelanderAn efficient synthetic route to a series of substituted 2-aminopyrimidine (2-AP) derivatives has been developed. Several derivatives displayed the ability to modulate bacterial biofilm formation, exhibiting greater activity against Gram-positive strains than Gram-negative strains.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Erick A. Lindsey Source Type: research
Conformationally restricted dynamic supramolecular catalysts for substrate-selective epoxidationsEmail this article to a colleague.
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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06859A, PaperEsmaeil Sheibani, Kenneth WarnmarkA second generation of supramolecular catalysts has been developed displaying increased substrate selectivity in epoxidations of styrene and stilbene derivatives.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - February 3, 2012 Category: Molecular Biology Authors: Esmaeil Sheibani Source Type: research
Wide-range protein photo-crosslinking achieved by a genetically encoded N[varepsilon]-(benzyloxycarbonyl)lysine derivative with a diazirinyl moietyEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05321G, CommunicationTatsuo Yanagisawa, Nobumasa Hino, Fumie Iraha, Takahito Mukai, Kensaku Sakamoto, Shigeyuki YokoyamaA method for wide-range in vivo protein photo-crosslinking has been developed by the site-specific incorporation of a large, photo-crosslinkable, non-natural amino acid into proteins.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 3, 2012 Category: Molecular Biology Authors: Tatsuo Yanagisawa Source Type: research
UPLC-MS metabolic profiling of second trimester amniotic fluid and maternal urine and comparison with NMR spectral profiling for the identification of pregnancy disorder biomarkersEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05424H, PaperGoncalo Graca, Brian J. Goodfellow, Antonio S. Barros, Silvia Diaz, Iola F. Duarte, Konstantina Spagou, Kirill Veselkov, Elizabeth J. Want, John C. Lindon, Isabel M. Carreira, Eulalia Galhano, Cristina Pita, Ana M. GilA UPLC-MS study of 2nd trimester maternal urine and amniotic fluid to investigate metabolic effects of pregnancy disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 3, 2012 Category: Molecular Biology Authors: Goncalo Graca Source Type: research
Dense surface functionalization using peptides that recognize differences in organized structures of self-assembling nanomaterialsEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05435C, PaperToshiki Sawada, Hisakazu MiharaCell adhesion to the fine-structured peptide nanofiber was highly up-regulated by modification with the plural RGDS conjugated nanofiber specific peptides.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 3, 2012 Category: Molecular Biology Authors: Toshiki Sawada Source Type: research
Analysis of cell adhesion during early stages of colon cancer based on an extended multi-valued logic approachEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05277F, PaperDaniel V. Guebel, Ulf Schmitz, Olaf Wolkenhauer, Julio VeraHere we present the first large scale multi-valued logic model investigating the signalling pathways that regulate cell adhesion during colorectal cancer initiation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 3, 2012 Category: Molecular Biology Authors: Daniel V. Guebel Source Type: research
Forced homodimerization of the c-Fos leucine zipper in designed bHLHZ-like hybrid proteins MaxbHLH-Fos and ArntbHLH-FosEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05354C, PaperGang Chen, Antonia T. De Jong, Jumi A. ShinThe c-Fos leucine zipper does not homodimerize in its native bZIP. However, when fused to the bHLH motif to form a non-native hybrid, this zipper dimerizes, leading to DNA-binding function.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 3, 2012 Category: Molecular Biology Authors: Gang Chen Source Type: research
Development of diacyltetrol lipids as activators for the C1 domain of protein kinase CEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05452C, PaperNarsimha Mamidi, Sukhamoy Gorai, Rakesh Mukherjee, Debasis MannaExperimental and computational studies were carried out to provide insights into the PKC C1b domain binding by the novel diacyltetrol lipids.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 3, 2012 Category: Molecular Biology Authors: Narsimha Mamidi Source Type: research
