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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 28.

LSUHSC research provides new drug target for Her-2 related breast cancer
(Louisiana State University Health Sciences Center) Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, details exactly how the Her2 cancer gene promotes the progression and spread of breast cancer cells. The inactivation of a tumor suppression gene called Nischarin is among the mechanisms identified. The findings provide a new therapeutic target to block the function of Her2.
Source: EurekAlert! - Medicine and Health - January 22, 2013 Category: Global & Universal Source Type: news

2013 Louis-Jeantet Prize for Medicine
(European Molecular Biology Organization) The 2013 Louis-Jeantet Prize for Medicine is awarded to the geneticist, Michael Stratton, director of the Wellcome Trust Sanger Institute in Cambridge, and jointly to the German biochemists Peter Hegemann, researcher at the Department of Experimental Biophysics at the Humboldt University, Berlin, and Georg Nagel, researcher at the Institute Julius-von-Sachs at the Biocenter, University of Wurzburg.
Source: EurekAlert! - Medicine and Health - January 22, 2013 Category: Global & Universal Source Type: news

A highly selective and efficient single molecular FRET based sensor for ratiometric detection of Fe3+ ions
Analyst, 2013, Advance ArticleDOI: 10.1039/C3AN36577H, CommunicationNarendra Reddy Chereddy, Sathiah Thennarasu, Asit Baran MandalA selective and efficient FRET based sensor for the ratiometric detection of Fe3+ in aqueous and biological samples is presented.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - January 21, 2013 Category: Chemistry Authors: Narendra Reddy Chereddy Source Type: research

Reply
Michel and colleagues enlighten us on the molecular biology underlying aneurysm rupture, from which arise their considerations with respect to multilayer flow diverting stents (FDSs). Similarly, we add our skepticism about the efficiency and indications for use of this novel technique of endovascular treatment of aortic aneurysms. From the limited data available in the current literature, it seems that although FDSs provide blood flow diversion from the aneurysm sac into the side branches of the aneurysm, they do not cause complete cessation of the flow inside the sac, at least for the first few months after their implanta...
Source: Journal of Vascular Surgery - January 21, 2013 Category: Surgery Authors: Andreas M. Lazaris Tags: Letters to the Editor Source Type: research

Regarding “A multilayer stent in the aorta may not seal the aneurysm, thereby leading to rupture”
Lazaris and colleagues report the first case of aortic rupture after implantation of a flow-diverting stent (FDS) in abdominal aortic aneurysms (AAAs). There are now clinical, biological, and radiological data establishing that intraluminal thrombus (ILT) may be one of the driving forces in the evolution of dilation toward ruptures of AAAs. ILT is a main source of proteases and oxidation in AAAs as it is involved in the activation of plasmin and the retention of neutrophils. ILT is also a potential site of weak pathogen contamination. The pathogenic spatiotemporal role of an ILT is directly linked to its permanent renewal ...
Source: Journal of Vascular Surgery - January 21, 2013 Category: Surgery Authors: Jean-Baptiste Michel, Martin Rouer, Jean-Marc Alsac Tags: Letters to the Editor Source Type: research

Molecular forces are key to proper cell division
New details emerge about a molecular surveillance system that helps detect and correct errors in mitosis that can lead to cell death or human diseases. Biologists can watch and record images of the key players including microtubules, kinetochores, molecular engines and the polar ejection force.
Source: ScienceDaily Headlines - January 21, 2013 Category: Science Source Type: news

Amounts and compositional analysis of glycosaminoglycans in the tissue of fish.
, Ishihara Y, Yoshioka S, Yoshioka S, Shirade S, Tamura J Abstract We isolated GAGs from the inedible parts; head, skin, internal organs, fins, scales and spine, of atlantic mackerel (Scomber scombrus), japanese jack mackerel (Trachurus japonicus), pacific bluefin tuna (Thunnus orientalis), yellowfin sole (Limanda aspera), broadbanded thornyhead (Sebastolobus macrochir), golden threadfin bream (Nemipterus virgatus), and nile tilapia (Oreochromis niloticus). We also investigated deep-sea fish, eelpouts (Bothrocara hollandi, Lycodes toyamensis, and Lycodes nakamurae), rough snailfish (Careproctus trachysoma), and squ...
Source: Carbohydrate Research - January 21, 2013 Category: Genetics & Stem Cells Authors: Arima K, Fujita H, Toita R, Imazu-Okada A, Tsutsumishita-Nakai N, Takeda N, Nakao Y, Wang H, Kawano M, Matsushita K, Tanaka H, Morimoto S, Nakamura A, Kitagaki M, Hieda Y, Hatto R, Watanabe A, Yumura T, Okuhara T, Hayashi H, Shimizu K, Nakayama K, Masuda Tags: Carbohydr Res Source Type: research

Revising The Technology Of The Post-Genomic Age And Its Contributions To The Advance Of Biomedicine
The enormous complexity of biological processes requires the use of highÂperformance technologies (also known as 'Âomics') that are capable of carrying out complete integrated analyses of the thousands of molecules that cells are made up of, and of studying their role in illnesses. In the post-genomic age we find ourselves in, the comprehensive study of cellular proteins -proteomics - acquires a new dimension, as proteins are the molecular executors of genes and, therefore, the most important pieces of the puzzle if we wish to understand more completely how cells work...
Source: Health News from Medical News Today - January 21, 2013 Category: Consumer Health News Tags: Genetics Source Type: news

A Molecular Mechanism For Generation Of Large Force Inside Cells
To live is to move. You strike to swat that irritable mosquito, which skilfully evades the hand of death. How did that happen? Who moved your hand, and what saved the mosquito? Enter the Molecular Motors, nanoscale protein-machines in the muscles of your hand and wings of the mosquito. You need these motors to swat mosquitoes, blink your eyes, walk, eat, drink... just name it. Millions of motors tug as a team within your muscles, and you swat the mosquito. This is teamwork at its exquisite best...
Source: Health News from Medical News Today - January 21, 2013 Category: Consumer Health News Tags: Biology / Biochemistry Source Type: news

Biomarkers for Prediction and Diagnosis of Necrotizing Enterocolitis
This article summarizes the commonly used biomarkers currently available for diagnosis of necrotizing enterocolitis. The most exciting advances in diagnostic tests were the use of new nucleic acid sequencing techniques (eg, next-generation sequencing) and molecular screening methods (eg, proteomics and microarray analysis) for the discovery of novel biomarkers. The new technology platform coupled with stringent protocols of biomarker discovery and validation would enable neonatologists to study biologic systems at a level never before possible and discover unique biomarkers for specific organ injury and/or disease entity.
Source: Clinics in Perinatology - January 21, 2013 Category: Perinatology & Neonatology Authors: Pak C. Ng, Kathy Y.Y. Chan, Terence C.W. Poon Source Type: research

Design, synthesis and biological evaluation of bivalent ligands against A(1)-D(1) receptor heteromers.
Conclusion:This study demonstrates the existence of A(1)-D(1)R in situ and a simultaneous interaction of bivalent ligands with both the receptors. PMID: 23334237 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - January 21, 2013 Category: Drugs & Pharmacology Authors: Shen J, Zhang L, Song WL, Meng T, Wang X, Chen L, Feng LY, Xu YC, Shen JK Tags: Acta Pharmacol Sin Source Type: research

ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1.
Abstract Gout, a common form of inflammatory arthritis, is strongly associated with elevated uric acid concentrations in the blood (hyperuricemia). A recent study in Icelanders identified a rare missense single nucleotide polymporphism (SNP) in the ALDH16A1 gene, ALDH16A1∗2, to be associated with gout and serum uric acid levels. ALDH16A1 is a novel and rather unique member of the ALDH superfamily in relation to its gene and protein structures. ALDH16 genes are present in fish, amphibians, protista, bacteria but absent from archaea, fungi and plants. In most mammalian species, two ALDH16A1 spliced variants (ALDH16...
Source: Chemico-Biological Interactions - January 21, 2013 Category: Molecular Biology Authors: Vasiliou V, Sandoval M, Backos DS, Jackson BC, Chen Y, Reigan P, Lanaspa MA, Johnson RJ, Koppaka V, Thompson DC Tags: Chem Biol Interact Source Type: research

Separation of Nadolol Stereoisomers by Chiral Liquid Chromatography at Analytical and Preparative Scales.
Abstract The separation of the four nadolol stereoisomers on Chiralpak® AD by chiral liquid chromatography was carried out at both analytical and preparative scales. A screening of possible mobile-phase compositions was performed using different alcohol-hydrocarbon mixtures. The results obtained confirm the use of 20:80:0.3 ethanol-hexane-diethylamine reported by McCarthy (1994) but introduce other possibilities for the complete resolution of the four nadolol stereoisomers at analytical scale, namely, the mixtures 30-40:70-60:0.3 ethanol-heptane-diethylamine. Additionally, this work describes how retention and res...
Source: Chirality - January 21, 2013 Category: Molecular Biology Authors: Ribeiro AE, Rodrigues AE, Pais LS Tags: Chirality Source Type: research

Estrogen synthesis and signaling pathways during aging: from periphery to brain.
Abstract Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and brain, and tissue-specific estrogen synthesis is consistent with a diversity of estrogen actions. In this article we review tissue and cell-specific estrogen synthesis and estrogen receptor signaling in three parts: (i) synthesis and metabolism, (ii) the distribution of estrogen receptors and signaling, and (iii) estrogen functions and related disorders, including cardiovascular diseases, ost...
Source: Trends in Molecular Medicine - January 21, 2013 Category: Molecular Biology Authors: Cui J, Shen Y, Li R Tags: Trends Mol Med Source Type: research

Clinical relevance of plasma miR-106b levels in patients with chronic obstructive pulmonary disease.
Abstract Chronic obstructive pulmonary disease (COPD) is characterized by both chronic inflammation in the airway and systemic inflammation; however, the molecular mechanism of COPD has not been fully elucidated. By measuring microRNA (miRNA) expression in the plasma of COPD subjects, we aimed to identify the clinical relevance of plasma miRNA levels in these patients. Blood samples were obtained from COPD patients and age-matched normal controls. We initially produced plasma miRNA expression profiles using TaqMan low-density array screening. For further validation, individual qRT-PCRs were performed in 40 COPD pa...
Source: International Journal of Molecular Medicine - January 21, 2013 Category: Molecular Biology Authors: Soeda S, Ohyashiki JH, Ohtsuki K, Umezu T, Setoguchi Y, Ohyashiki K Tags: Int J Mol Med Source Type: research

Advanced Glycation End-Products Diminish Tendon Collagen Fiber Sliding.
In this study, we utilized a rat tail tendon model to quantify the micro-mechanical repercussion of AGEs at the collagen fiber-level. Individual tendon fascicles were incubated with methylglyoxal (MGO), a naturally occurring metabolite known to form AGEs. After incubation in MGO solution or buffer only, tendons were stretched on the stage of a multiphoton confocal microscope and individual collagen fiber stretch and relative fiber sliding were quantified. Treatment by MGO yielded increased fluorescence and elevated denaturation temperatures as found in normally aged tissue, confirming formation of AGEs and related cross-li...
Source: Matrix Biology - January 21, 2013 Category: Molecular Biology Authors: Li Y, Fessel G, Georgiadis M, Snedeker JG Tags: Matrix Biol Source Type: research

BLyS upregulation in Sjogren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands
Conclusion. Higher s-BLyS levels and tissue clonal B-cell expansion characterize SS with B-cell lymphoproliferative disorders, even at prelymphomatous stages. This subgroup of SS patients showed the highest EULAR SS disease activity index scores. This represents a biologic rationale for targeting both clonal B-cell expansion and s-BLyS overproduction in SS.
Source: Rheumatology - January 21, 2013 Category: Rheumatology Authors: Quartuccio, L., Salvin, S., Fabris, M., Maset, M., Pontarini, E., Isola, M., De Vita, S. Tags: Sjogren's Syndrome CLINICAL SCIENCE Source Type: research

In the News
Epigenetics: How Our Experiences Affect Our Offspring “We were all brought up to think the genome was it,” said Rockefeller University molecular biologist C. David Allis. “It’s really been a watershed in understanding that there is something beyond the … More »
Source: The Rockefeller University Newswire - January 20, 2013 Category: Biomedical Science Authors: pubaff Tags: In the News Source Type: news

Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains
Nature Structural & Molecular Biology 20, 222 (2013). doi:10.1038/nsmb.2486 Authors: Swetansu K Hota, Saurabh K Bhardwaj, Sebastian Deindl, Yuan-chi Lin, Xiaowei Zhuang & Blaine Bartholomew
Source: Nature Structural and Molecular Biology - January 20, 2013 Category: Molecular Biology Authors: Swetansu K HotaSaurabh K BhardwajSebastian DeindlYuan-chi LinXiaowei ZhuangBlaine Bartholomew Tags: Article Source Type: research

Conformational ensemble of the sodium-coupled aspartate transporter
Nature Structural & Molecular Biology 20, 215 (2013). doi:10.1038/nsmb.2494 Authors: Elka R Georgieva, Peter P Borbat, Christopher Ginter, Jack H Freed & Olga Boudker
Source: Nature Structural and Molecular Biology - January 20, 2013 Category: Molecular Biology Authors: Elka R GeorgievaPeter P BorbatChristopher GinterJack H FreedOlga Boudker Tags: Article Source Type: research

Conformational heterogeneity of the aspartate transporter GltPh
Nature Structural & Molecular Biology 20, 210 (2013). doi:10.1038/nsmb.2471 Authors: Inga Hänelt, Dorith Wunnicke, Enrica Bordignon, Heinz-Jürgen Steinhoff & Dirk Jan Slotboom
Source: Nature Structural and Molecular Biology - January 20, 2013 Category: Molecular Biology Authors: Inga HäneltDorith WunnickeEnrica BordignonHeinz-Jürgen SteinhoffDirk Jan Slotboom Tags: Article Source Type: research

Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo
Nature Cell Biology 15, 214 (2013). doi:10.1038/ncb2660 Authors: Caroline Rouaux & Paola Arlotta Once programmed to acquire a specific identity and function, cells rarely change in vivo. Neurons of the mammalian central nervous system (CNS) in particular are a classic example of a stable, terminally differentiated cell type. With the exception of the adult neurogenic niches, where a limited set of neuronal subtypes continue to be generated throughout life, CNS neurons are born only during embryonic and early postnatal development. Once generated, neurons become permanently post-mitotic and do not change their i...
Source: Nature Cell Biology - January 20, 2013 Category: Cytology Authors: Caroline RouauxPaola Arlotta Tags: Letter Source Type: research

Mechanisms of bronchopulmonary dysplasia.
Abstract Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants with long term effect on lung function into adulthood. Multiple factors are involved in the development of BPD. This review will summarize the different mechanisms leading to this disease and highlight recent bench and clinical research targeted at understanding the role of the mesenchyme (both its cellular and extracellular components) in the pathogenesis of BPD. PMID: 23334556 [PubMed - as supplied by publisher]
Source: Journal of Cell Communication and Signaling - January 20, 2013 Category: Molecular Biology Authors: Popova AP Tags: J Cell Commun Signal Source Type: research

La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
(La Jolla Institute for Allergy and Immunology) A research team led by the La Jolla Institute for Allergy & Immunology has discovered the mechanism that enables CD4 helper T cells to assume the more aggressive role of killer T cells in mounting an immune attack against viruses, cancerous tumors and other damaged or infected cells. The finding, made in collaboration with researchers from the RIKEN Institute in Japan, could enable the development of more potent drugs for AIDS, cancer and many other diseases.
Source: EurekAlert! - Biology - January 20, 2013 Category: Biology Source Type: news

Antigen Processing
Methods and Protocolsseries:Methods in Molecular BiologyAntigen processing is a biological process that prepares antigens for the presentation to special cells in the immune system called T lymphocytes. In Antigen Processing: Methods and Protocols, expert researchers in the field provide a comprehensive set of protocols for studying presentation of antigens produced in the standard processing pathways for MHC class I and class II molecules. The ...
Source: Springer Biomedical Sciences titles - January 19, 2013 Category: Biomedical Science Tags: Immunology Source Type: news

Bis-vinyl selenides obtained via iron(III) catalyzed addition of PhSeSePh to alkynes: synthesis and antinociceptive activity
We present here the synthesis and antinociceptive activity of bis-vinyl selenides prepared via FeCl3 promoted reaction addition of diorganyl dichalcogenides to alkynes. The pharmacological results demonstrated that 3a, 3d, 3h and 3t elicited antinociceptive effect.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Glaubia Sartori Source Type: research

Low molecular weight PEI-based biodegradable lipopolymers as gene delivery vectors
Org. Biomol. Chem., 2013, Advance ArticleDOI: 10.1039/C2OB27211C, PaperMiao-Miao Xun, Xue-Chao Zhang, Ji Zhang, Qian-Qian Jiang, Wen-Jing Yi, Wen Zhu, Xiao-Qi YuA series of LMW PEI-based polymers containing both hydrophobic and biodegradable parts were synthesized and used as non-viral gene delivery vectors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Miao-Miao Xun Source Type: research

Selective reduction of condensed N-heterocycles using water as a solvent and a hydrogen source
Org. Biomol. Chem., 2013, Advance ArticleDOI: 10.1039/C2OB26903A, PaperHyejin Cho, Fanni Torok, Bela TorokThe reduction of unprotected indoles and quinolines is described using water as a hydrogen source.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Hyejin Cho Source Type: research

Metal-catalyzed rearrangements of 3-allenyl 3-hydroxyindolin-2-ones in the presence of halogenated reagents
Org. Biomol. Chem., 2013, Advance ArticleDOI: 10.1039/C2OB27359D, PaperBenito Alcaide, Pedro Almendros, Amparo Luna, Natividad PrietoRearrangement and oxycyclization reactions to give 4-(1-halovinyl)-quinolinediones or spirocyclic halooxindoles, respectively, are competitive pathways in the metal-catalyzed reactions of 3-allenyl with halogenated reagents.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Benito Alcaide Source Type: research

A sterically demanding organo-superbase avoids decomposition of a naked trifluoromethyl carbanion directly generated from fluoroform
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB27368G, CommunicationHiroyuki Kawai, Zhe YUAN, Etsuko Tokunaga, Norio ShibataA simple strategy avoiding the decomposition of a naked trifluoromethyl anion to difluorocarbene by a sterically very demanding organo-superbase without the help of a trifluoromethyl anion reservoir such as DMF...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Hiroyuki Kawai Source Type: research

Iodine-catalyzed disproportionation of aryl-substituted ethers under solvent-free reaction conditions
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB27267B, PaperMarjan Jereb, Dejan VrazicIodine was demonstrated to be an efficient catalyst for disproportionation of aryl-substituted ethers under solvent-free reaction conditions. Variously substituted 1,1,1',1'-tetraaryldimethyl ethers were transformed into the corresponding diarylketone and diarylmethane derivatives....The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Marjan Jereb Source Type: research

Synthesis and properties of 2[prime or minute]-O-neopentyl modified oligonucleotides
Org. Biomol. Chem., 2013, Advance ArticleDOI: 10.1039/C2OB26871J, PaperGerald Mathis, Stephane Bourg, Samia Aci-Seche, Jean-Christophe Truffert, Ulysse AsselineSynthesis of 2[prime or minute]-O-neopentyldeoxyuridine modified oligodeoxyribonucleotides. Base-pairing with DNA and RNA was studied by absorption spectroscopy, circular dichroism and molecular dynamic simulations.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Gerald Mathis Source Type: research

New Trends in Bismuth-catalyzed Synthetic Transformations
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB26537D, Emerging AreaThierry OllevierThis review covers the most recent uses of bismuth catalysts since 2005 with a special emphasis on the emerging applications of such catalysts. Low toxicity, low catalytic loading, synergistic effects...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Thierry Ollevier Source Type: research

First diastereoselective [3+2] cycloaddition reaction of diethyl isocyanomethylphosphonate and maleimides
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB26766K, PaperCarmen Escolano, Juan Molina, Sonia Abas, Elies Molins, Carlos Arroniz, Javier Luque, Josep M CampaneraThe first [3+2]cycloaddition silver-catalysed reaction of diethyl isocyanomethylphosphonate and N-substituted maleimides is described. The reaction proceeded with complete diastereoselectivity to furnish bicyclic -iminophosphonates, which were reduced to access bicyclic -aminophosphonates.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Carmen Escolano Source Type: research

Chemoenzymatic total synthesis of hyperiones A and B
Org. Biomol. Chem., 2013, Advance ArticleDOI: 10.1039/C2OB27073K, PaperChicco Manzuna Sapu, Jan DeskaThe first asymmetric total synthesis of hyperiones A and B based on a chemoenzymatic approach is described.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Chicco Manzuna Sapu Source Type: research

A concise one-pot synthesis of trifluoromethyl-containing 2,6-disubstituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydronaphthyridines
Org. Biomol. Chem., 2013, Advance ArticleDOI: 10.1039/C2OB27113C, PaperRussell J. Johnson, Donogh J. R. O'Mahony, William T. Edwards, Matthew A. J. DunctonA three-step/one-pot procedure for the synthesis of the title compounds is presented. The methodology is particularly useful for installing a trifluoromethyl-group as part of a tertiary-substituent.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Russell J. Johnson Source Type: research

Efficient synthesis of silylated 2,2-difluorostyrene derivatives through Suzuki-Miyaura cross-coupling of 2,2-difluoro-1-iodo-1-silylethenes
We report a new synthetic sequence for the preparation of silylated 2,2-difluorostyrene derivatives.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Marc-Olivier Turcotte-Savard Source Type: research

Direct use of formamides as amino group sources via C-N bond cleavage: A catalytic oxidative synthesis of [small alpha]-ketoamides from acetophenones and formamides under metal-free conditions
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB27433K, PaperQiong Zhao, Tao Miao, Xiaobin Zhang, Wei Zhou, Lei WangAn efficient and direct use of formamides as amino group sources for the synthesis of [small alpha]-ketoamides was developed under metal-free conditions. The reaction was based on the oxidative coupling of...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Qiong Zhao Source Type: research

Synthesis and Structure-Activity Relationship Studies of Novel Tubulysin U Analogues - Effect on Cytoxicity of Structural Variations in the Tubuvaline Fragment
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB27111K, PaperMatteo Zanda, Sreejith P Shankar, Monika Jagodzinska, Monica Sani, Luciana Malpezzi, Paolo Lazzari, Ilaria Manca, Iain R GreigTubulysins are cytotoxic natural products with promising anti-cancer properties, originally isolated from myxobacterial cultures. Structurally, tubulysins are tetrapeptides, incorporating three unusual (Mep, Tuv and Tup) and one proteinogenic amino acid...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Matteo Zanda Source Type: research

A new family of bis-ureidic receptors for pyrophosphate optical sensing
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB27244C, PaperClaudia Caltagirone, Carla Bazzicalupi, Francesco Isaia, Mark E. Light, Vito Lippolis, Riccardo Montis, Sergio Murgia, Martina Olivari, Giacomo PicciA new family of bis-ureidic receptors (L1-L6) has been synthesised. The binding properties of L1-L6 towards different anions (acetate, benzoate, glutarate, malonate, dihydrogen phosphate, hydrogen pyrophosphate, triphosphate, AMP and ADP)...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Claudia Caltagirone Source Type: research

Asymmetric Rearrangement of Racemic Epoxides Catalyzed by Chiral Bronsted Acids
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB27285K, CommunicationMinyang Zhuang, HAIFENG DUThis paper describes a chiral Bronsted acid catalyzed asymmetric 1,2-rearrangement of racemic epoxides via a hydrogen-shift process for the synthesis of chiral aldehydes, and followed by a reduction, a variety...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Minyang Zhuang Source Type: research

Study of the stereoselectivity of 2-azido-2-deoxyglucosyl donors: protecting group effects
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB26994A, PaperGeorge Ngoje, Zhitao LiA series of tolyl 2-azido-2-deoxy-thio-glucoside donors with different combination of protecting groups were prepared. These donors were used in glycosylation reactions to test the correlation between the stereoselectivity and the...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: George Ngoje Source Type: research

Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB00011G, PaperJorge Salvador, Ana Leal, Yongkui Jing, Rui WangA series of new oleanane imidazole carmabates, N-acylimidazoles or N-alkylimidazoles were synthesized, characterized and evaluated for their antiproliferative activity in AsPC-1 pancreatic cancer cells. Structure activity relationship analysis revealed that...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Jorge Salvador Source Type: research

Mechanism of Arylboronic Acid-Catalyzed Amidation Reaction between Carboxylic Acids and Amines
, 2013, Accepted ManuscriptDOI: 10.1039/C3OB27367A, PaperChen Wang, Hai-zhu Yu, Qingxiang Guo, Yao FuArylboronic acids were found to be efficient catalysts for the amidation reactions between carboxylic acids and amines. Theoretical calculations have been carried out to investigate the mechanism of this catalytic...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Chen Wang Source Type: research

First total synthesis of Debilisone C
Org. Biomol. Chem., 2013, 11,905-913DOI: 10.1039/C2OB26329G, PaperBishwajit Saikia, Thongam Joymati Devi, Nabin C. BaruaThe total synthesis of Debilisone C, a lactone containing conjugated endiyne has been achieved. The adopted strategy involves the stereoselective construction of the five membered lactone ring and the C20 endiyne chain followed by regioselective coupling of both the parts.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Bishwajit Saikia Source Type: research

Benzimidazolium-based synthetic chloride and calcium transporters in bacterial membranes
Org. Biomol. Chem., 2013, 11,923-928DOI: 10.1039/C2OB26966J, PaperClaude-Rosny Elie, Audrey Hebert, Mathieu Charbonneau, Adam Haiun, Andreea R. SchmitzerHerein, we present the first example of a benzimidazolium-based artificial transmembrane chloride transporter and a synthetic calcium ionophore that can regulate intracellular calcium concentrations in bacteria.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Claude-Rosny Elie Source Type: research

Reply to "A further study of acetylacetone nitrosation"
Org. Biomol. Chem., 2013, 11,1065-1070DOI: 10.1039/C2OB26719E, PaperLuis Garcia-Rio, Mercedes Parajo, Moises Perez-LorenzoThis work constitutes a reply to the comments raised by Iglesias et al. on the mechanistic nature of acetylacetone nitrosation.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Luis Garcia-Rio Source Type: research

Asymmetric organocatalytic allylic alkylation of Reissert compounds: a facile access to chiral 1,1-disubstituted 1,2-dihydroisoquinolines
Org. Biomol. Chem., 2013, 11,984-990DOI: 10.1039/C2OB27269E, PaperTian-You Qin, Wei-Wei Liao, Yan-Jing Zhang, Sean Xiao-An ZhangThe first metal-free asymmetric catalytic allylic alkylation of Reissert compounds and MBH carbonates has been developed, which provides a facile access to enantioenriched functionalized 1,2-dihydroisoquinolines bearing vicinal quaternary and tertiary chiral centers.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Tian-You Qin Source Type: research

2,6-Bis(functionalized) purines as metal-ion-binding surrogate nucleobases that enhance hybridization with unmodified 2[prime or minute]-O-methyl oligoribonucleotides
Org. Biomol. Chem., 2013, 11,991-1000DOI: 10.1039/C2OB26885J, PaperSharmin Taherpour, Harri Lonnberg, Tuomas LonnbergTerminal Cu2+-mediated base pairs dramatically stabilize short oligonucleotide duplexes, without compromising sequence-selectivity.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Sharmin Taherpour Source Type: research

Unexpected N-glycosidation reaction of glycals with 1-amino-anthracene: structure revision and application to the synthesis of new analogues of marmycin A
Org. Biomol. Chem., 2013, Advance ArticleDOI: 10.1039/C2OB27020J, PaperXuefeng Zhang, Xiaolong Jiang, Chunyong Ding, Qizheng Yao, Ao ZhangAn unexpected N-glycosidation reaction of anthracen-1-amine with glycals was identified, and novel compounds bearing a quaternary carbon center were obtained as analogs of natural product marmycin A.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - January 19, 2013 Category: Molecular Biology Authors: Xuefeng Zhang Source Type: research