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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Inhibition of nuclear factor kappa B transcription activity drives a synergistic effect of pyrrolidine dithiocarbamate and cisplatin for treatment of renal cell carcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study, we examined the synergistic effect of pyrrolidine dithiocarbamate (PDTC), a NF-κB inhibitor, and cisplatin, on two human metastatic RCC cell lines ACHN and SN12K1. Individual non-toxic concentrations of PDTC and cisplatin, when combined, synergistically induced a significant increase in apoptosis of the two RCC cell lines. In ACHN cells, the groups with nuclear translocation of NF-κB showed resistance to apoptosis, but in SN12K1 cells, the groups with NF-κB translocation were susceptible to apoptosis. The combination treatment significantly decreased the transcription activity of all NF-κB subunits i...
Source: Apoptosis - October 23, 2009 Category: Molecular Biology Tags: Apoptosis Source Type: journals

Involvement of tyrosine phosphatase CD45 in apoptosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  CD45 is a transmembrane molecule with phosphatase activity expressed in all nucleated haematopoietic cells and plays a major role in immune cells. It is a protein tyrosine phosphatase that is essential for antigen-receptor-mediated signal transduction by regulating Src family members that initiate TCR signaling. CD45 is being attributed a new emerging role as an apoptosis regulator. Cross-linking of the extracellular portion of the CD45 by monoclonal antibodies and by galectin-1, can induce apoptosis in T and B cells. Interestingly, this phosphatase has also been involved in nuclear apoptosis induce...
Source: Apoptosis - October 23, 2009 Category: Molecular Biology Tags: Apoptosis Source Type: journals

Highlights of the november issue.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PMID: 19843709 [PubMed - in process]
Source: American Journal of Respiratory Cell and Molecular Biology - October 23, 2009 Category: Molecular Biology Authors: Adler KB, Matalon S Tags: Am J Respir Cell Mol Biol Source Type: journals

An evolutionary perspective on chronic obstructive pulmonary disease.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PMID: 19843710 [PubMed - in process]
Source: American Journal of Respiratory Cell and Molecular Biology - October 23, 2009 Category: Molecular Biology Authors: Aoshiba K, Nagai A Tags: Am J Respir Cell Mol Biol Source Type: journals

Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Previously we reported that serum leucine-rich alpha-2-glycoprotein-1 (LRG) binds cytochrome c (Cyt c; Cummings et al., Apoptosis 11:1121–1129, 2009). Here we show that LRG binding to Cyt c is similar to that of Apaf-1. LRG and Apaf-1 share partial amino acid sequences, compete for binding Cyt c, and are inhibited by modification at lysine 72 in Cyt c. However, in contrast to Apaf-1, LRG acts as a survival factor in vitro rather than a pro-apoptotic factor. By depleting LRG from culture medium we found that LRG protects against a toxic effect of exogenous Cyt c on lymphocytes that would otherwise res...
Source: Apoptosis - October 23, 2009 Category: Molecular Biology Tags: Apoptosis Source Type: journals

Inhibiting TNF-mediated signaling: a novel therapeutic paradigm for androgen independent prostate canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  The tumor necrosis factor (TNF) receptor super family comprises of members that induce two distinct signaling cascades, leading to either cell survival or apoptosis. However, in prostate cancer (PCa), TNF-mediated prosurvival signaling is the predominant pathway that leads to cell survival and resistance to therapy. Although inhibition of TNF signaling by pharmacological agents or monoclonal antibodies has gained importance in the field of cancer therapy, toxicity to normal cells has impaired their extensive use for cancer treatment. We previously identified a natural, nontoxic compound psoralidin t...
Source: Apoptosis - October 23, 2009 Category: Molecular Biology Tags: Apoptosis Source Type: journals

CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
TNFAIP1 is a protein which can be induced by tumor necrosis factoralpha (TNFalpha) and interleukin-6 (IL-6), it may play roles in DNA synthesis, DNA repair, cell apoptosis and human diseases. However, very little has been known about how TNFAIP1 acts in these physiological processes. In this paper, CK2beta was identified as a partner of TNFAIP1 by screening the HeLa cDNA library in yeast two-hybrid system with TNFAIP1 as a bait. Furthermore, it was demonstrated that CK2 could phosphorylate TNFAIP1 in vitro and in vivo, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA. It i...
Source: Molecular Biology Reports - October 23, 2009 Category: Molecular Biology Authors: Yang L, Liu N, Hu X, Zhang W, Wang T, Li H, Zhang B, Xiang S, Zhou J, Zhang J Tags: Mol Biol Rep Source Type: journals

The World Health Organization (WHO) Classification of Tumors of the Hematopoietic and Lymphoid Tissues: An overview with emphasis on the myeloid neoplasms.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The World Health Organization (WHO) classification of myeloid and lymphoid neoplasms utilizes morphology, immunophenotype, genetics and clinical features to define disease entities of clinical significance. It is a consensus classification in which a number of experts have agreed on the classification and diagnostic criteria. In general, the classification stratifies neoplasms according to their lineage (myeloid, lymphoid, histiocytic/dendritic) and distinguishes neoplasms of precursor cells from those comprised of functionally mature cells. Lymphoid neoplasms are derived from cells that frequently have features that r...
Source: Chemico-Biological Interactions - October 23, 2009 Category: Molecular Biology Authors: Vardiman JW Tags: Chem Biol Interact Source Type: journals

Native LDL-induced oxidative stress in human proximal 1 tubular cells: multiple players involved.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study aimed to examine the effects of native non oxidized LDL on cellular oxidative metabolism in cultured human proximal tubular cells. By means of confocal microscopy imaging combined to respirometric and enzymatic assays it is shown that purified native LDL caused a marked increase of cellular ROS production which was mediated by activation of NADPH oxidase(s) and by mitochondrial dysfunction by means of a ROS-induced ROS release mechanism. The LDL-dependent mitochondrial alterations comprised inhibition of the respiratory chain activity, enhanced ROS production, uncoupling of the oxidative phosphorylation efficien...
Source: J Cell Mol Med - October 23, 2009 Category: Molecular Biology Authors: Piccoli C, Quarato G, D'Aprile A, Montemurno E, Scrima R, Ripoli M, Gomaraschi M, Cirillo P, Boffoli D, Calabresi L, Gesualdo L, Capitanio N Tags: J Cell Mol Med Source Type: journals

Maternal thyroid hormones are transcriptionally active during embryo-fetal development: results from a novel transgenic mouse model.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: our results provide in vivo direct evidence that during embryonic life and before the onset of FTF, maternal THs are transcriptionally active through the action of embryonic TRs. This model may have clinical relevance and may be employed to design endpoint assays for new molecules affecting THs action. PMID: 19863697 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - October 23, 2009 Category: Molecular Biology Authors: Nucera C, Muzzi P, Tiveron C, Farsetti A, La Regina F, Foglio B, Shih SC, Moretti F, Pietra LD, Mancini F, Sacchi A, Trimarchi F, Vercelli A, Pontecorvi A Tags: J Cell Mol Med Source Type: journals

Ox-LDL modifies the behavior of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In conclusion, ox-LDL promotes apoptosis and inhibits Oct-4 expression and self-renewal of MAPCs, and impairs their endothelial differentiation via suppression of Akt signaling. PMID: 19863696 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - October 23, 2009 Category: Molecular Biology Authors: Chu L, Hao H, Luo M, Huang Y, Chen Z, Lu T, Zhao X, Verfaillie CM, Zweier JL, Liu Z Tags: J Cell Mol Med Source Type: journals

Preservation of TSPO by chronic intermittent hypobaric hypoxia confers antiarrhythmic activity.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract Abnormal activation of mitochondrial translocator protein (TSPO) contributes to arrhythmogenesis during cardiac metabolic compromise; however, its role in the antiarrhythmic activities of chronic hypoxia adaptation remains unclear. Our results demonstrated that 80% of normoxic rats developed ischemic VF, whereas this condition was seldom observed in rats with 14-days of chronic intermittent hypobaric hypoxia (CIHH). TSPO stimulation or inhibition affected the arrhythmias incidence in normoxic rats, but did not change the CIHH-mediated antiarrhythmic effects. Abrupt and excessive elevation of TSPO activity was ...
Source: J Cell Mol Med - October 23, 2009 Category: Molecular Biology Authors: Li J, Xu J, Xiao J, Zhang H, Liang D, Liu Y, Zhang Y, Liu Y, Wen W, Hu Y, Yu Z, Yan B, Jiang B, Zhou ZN, Chen YH Tags: J Cell Mol Med Source Type: journals

Lipid droplet growth by fusion: insights from freeze-fracture imaging.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract An understanding of how lipid droplets grow in the cell is important to current human health issues. Homotypic fusion of small lipid droplets to create larger ones is one proposed mechanism though the evidence for this process continues to be debated. By applying the technique of freeze-fracture electron microscopy to cells that have been stimulated to accumulate lipid droplets, we here present images which suggest that at least some large lipid droplets may indeed result from amalgamation of multiple smaller ones. These visual data add significantly to the notion that fusion contributes to lipid droplet growt...
Source: J Cell Mol Med - October 23, 2009 Category: Molecular Biology Authors: Robenek H, Severs NJ Tags: J Cell Mol Med Source Type: journals

Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by host-derived urokinase-type plasminogen activator.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ABSTRACT Paradoxically, not only proteinases but also their inhibitors can correlate with bad prognosis of cancer patients, underlining the evolving concept of the protease web as the complex interplay between proteinases, their inhibitors, and effector molecules. Elevated levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) render the liver more susceptible to metastasis by triggering urokinase plasminogen activator (uPA) expression as well as hepatocyte growth factor (HGF) signalling, thereby leading to the fatal scattered infiltration of metastasizing tumour cells throughout the parenchyma of the target organ...
Source: J Cell Mol Med - October 23, 2009 Category: Molecular Biology Authors: Schrötzlmair F, Kopitz C, Halbgewachs B, Lu F, Algül H, Brünner N, Gänsbacher B, Krüger A Tags: J Cell Mol Med Source Type: journals

Sensing, physiological effects and molecular response to elevated CO(2) levels in eukaryotes.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract Carbon dioxide (CO(2)) is an important gaseous molecule that maintains biosphere homeostasis and is an important cellular signalling molecule in all organisms. The transport of CO(2) through membranes has fundamental roles in most basic aspects of life in both plants and animals. There is a growing interest in understanding how CO(2) is transported into cells, how it is sensed by neurons and other cell types, and in understanding the physiological and molecular consequences of elevated CO(2) levels (hypercapnia) at the cell and organism levels. Human pulmonary diseases and model organisms such as fungi, C. ele...
Source: J Cell Mol Med - October 23, 2009 Category: Molecular Biology Authors: Sharabi K, Lecuona E, Helenius IT, Beitel G, Sznajder JI, Gruenbaum Y Tags: J Cell Mol Med Source Type: journals

Genetic variation in MicroRNA genes and risk of oral premalignant lesionsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
MicroRNAs (miRNAs) have been reported to play a key role in oncogenesis and, recently, studies have examined the role miRNAs might play in the risk of premalignant lesions. To our knowledge, no study has investigated the association between miRNA polymorphisms and risk of oral premalignant lesions (OPLs). We genotyped 31 single nucleotide polymorphisms (SNPs) among 21 miRNA-related genes in a case-control study including 136 OPL patients and 136 matched controls. Patients with at least one variant allele of mir26a-1:rs7372209 had a significantly increased risk of OPL (OR, 2.09; 95% CI, 1.23-3.56). Likewise, patients with a...
Source: Molecular Carcinogenesis - October 22, 2009 Category: Molecular Biology Authors: Jessica Clague, Scott M. Lippman, Hushan Yang, Michelle A.T. Hildebrandt, Yuanqing Ye, J. Jack Lee, Xifeng Wu Source Type: journals

Development of small and inexpensive digital data acquisition systems using a microcontroller-based approachemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Fully digital data acquisition systems for use in flow cytometry provide excellent flexibility and precision. Here, we demonstrate the development of a low cost, small, and low power digital flow cytometry data acquisition system using a single microcontroller chip with an integrated analog to digital converter (ADC). Our demonstration system uses a commercially available evaluation board making the system simple to integrate into a flow cytometer. We have evaluated this system using calibration microspheres analyzed on commercial, slow-flow, and CCD-based flow cytometers. In our evaluations, our demonstration data system ...
Source: Cytometry Part A - October 22, 2009 Category: Molecular Biology Authors: Mark A. Naivar, Mark E. Wilder, Robert C. Habbersett, Travis A. Woods, David S. Sebba, John P. Nolan, Steven W. Graves Source Type: journals

Diagnostic fragmentations of adducts formed between carbanions and carbon disulfide in the gas phase. A joint experimental and theoretical studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Micheal J. Maclean, Scott Walker, Tianfang Wang, Peter C. H. Eichinger, Patrick J. Sherman, John H. Bowie (Paper from Org. Biomol. Chem.) Micheal J. Maclean, Org. Biomol. Chem., 2010, DOI: 10.1039/b916477d To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - October 22, 2009 Category: Molecular Biology Authors: Micheal J. MacleanScott Walker Tianfang Wang Peter C. H. Eichinger Patrick J. Sherman John H. Bowie Source Type: journals

Microwave-assisted three-component coupling-addition-SNAr (CASNAR) sequences to annelated 4H-thiopyran-4-onesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Benjamin Willy, Walter Frank, Thomas J. J. Muller (Paper from Org. Biomol. Chem.) Benjamin Willy, Org. Biomol. Chem., 2010, DOI: 10.1039/b917627f To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - October 22, 2009 Category: Molecular Biology Authors: Benjamin WillyWalter Frank Thomas J. J. Muller Source Type: journals

An efficient copper-catalyzed synthesis of hexahydro-1H- phenothiazinesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
D. J. C. Prasad, Govindasamy Sekar (Paper from Org. Biomol. Chem.) D. J. C. Prasad, Org. Biomol. Chem., 2009, DOI: 10.1039/b916664e To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - October 22, 2009 Category: Molecular Biology Authors: D. J. C. PrasadGovindasamy Sekar Source Type: journals

Nme protein family evolutionary history, a vertebrate perspectiveemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: This work offers an evolutionary framework that will pave the way for future studies on vertebrate Nme proteins and provides a unified vertebrate Nme nomenclature that is consistent with the nomenclature in use in mammals. Based on protein structure and expression data, we also provide new insight into molecular functions of Nme proteins among vertebrates and raise intriguing questions on the roles of Nme proteins in gonads.
Source: BMC Evolutionary Biology - Latest articles - October 22, 2009 Category: Molecular Biology Authors: Thomas DesvignesPierre PontarottiChristian FauvelJulien Bobe Source Type: journals

Controversies in cancer stem cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00109-009-0552-2Authors Richard J. Jones, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Room 244, Bunting-Blaustein Cancer Research Building, 1650 Orleans St. Baltimore MD 21231 USA Journal Journal of Molecular MedicineOnline ISSN 1432-1440Print ISSN 0946-2716
Source: Journal of Molecular Medicine - October 22, 2009 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals

Monash at the academic industrial interface: trains and platformsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00109-009-0545-1Authors Alexander Ian Smith, Monash University Faculty of Medicine, Nursing and Health Sciences Clayton Victoria AustraliaPhillip R. Thompson, Monash University Faculty of Medicine, Nursing and Health Sciences Clayton Victoria AustraliaDavid P. Gearing, Monash University Faculty of Medicine, Nursing and Health Sciences Clayton Victoria Australia Journal Journal of Molecular MedicineOnline ISSN 1432-1440Print ISSN 0946-2716
Source: Journal of Molecular Medicine - October 22, 2009 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals

BioEssays 11/2009email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Cover Photograph: Thermal noise is routine in the molecular world. Unsurprisingly, nature has not only adapted to it but found ways for its utilization. Actin polymerization, as well as many other cellular processes, is not a smooth process of lengthening or shortening of actin filaments but a random process vulnerable to thermal fluctuations. Fluctuation-driven subunit exchange between monomeric and polymeric actin pools, also called exchange diffusion, indirectly couples energy of ATP hydrolysis by polymeric actin to the energy of actin polymerization. This provides a basis for regulation of actin filament growth by an a...
Source: BioEssays - October 22, 2009 Category: Molecular Biology Tags: Cover Picture Source Type: journals

Grammatical-Restrained Hidden Conditional Random Fields for Bioinformatics Applications.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: We show that in a typical biosequence labeling problem the GRHCRF performs better than CRF models of the same complexity, indicating that GRHCRFs can be useful tools for biosequence analysis applications. AVAILABILITY: GRHCRF software is available under GPLv3 licence at the website http://www.biocomp.unibo.it/ savojard/biocrf-0.9.tar.gz. PMID: 19849839 [PubMed - as supplied by publisher]
Source: Algorithms for Molecular Biology : AMB - October 22, 2009 Category: Molecular Biology Authors: Fariselli P, Savojardo C, Martelli PL, Casadio R Tags: Algorithms Mol Biol Source Type: journals

An efficient high-throughput flow cytometric method for estimating DNA ploidy level in plantsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We present an efficient high-throughput flow cytometric method that builds on previously published methods and permits rapid ploidy discrimination in plants. By using Brassica napus L. microspore-derived plants as an example, we describe how 192 leaf tissue samples may be processed and analyzed comfortably by one operator in 6 h from tissue sampling to ploidy determination. The technique involves placing young leaf samples in two 96-well racks, using a bead-beating procedure to release nuclei into a lysis solution, filtering the samples on 96-well filter plates, staining with propidium iodide, and then rapidly estimating D...
Source: Cytometry Part A - October 21, 2009 Category: Molecular Biology Authors: A. Cousin, K. Heel, W. A. Cowling, M. N. Nelson Source Type: journals

Evaluation of a dry format reagent alternative for CD4 T-cell enumeration for the FACSCount system: A report on a Moroccan-Canadian studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Efforts to improve alternative CD4 T-cell counting methods are critical to accelerate the implementation of HIV antiretroviral therapy in resources limited regions. Substituting liquid format reagents to eliminate cold-chain transportation and refrigerated storage with dry format reagents contributes to higher efficiency supply management solution especially for laboratories at remote locations. ReaMetrix has developed dry format reagent kits compatible with the FACSCount system, a dedicated flow cytometer for T-cell subset enumeration widely used in resource limited settings. A dual site collaborative study was designed t...
Source: Cytometry Part B: Clinical Cytometry - October 21, 2009 Category: Molecular Biology Authors: Michèle Bergeron, Tao Ding, Elmir Elharti, Hicham Oumzil, Nadia Soucy, Hicham Harmouche, Saad Chaouch, Rajae EL Aouad, Christian Chabot, Francis Mandy Source Type: journals

Mechanism of glycoside hydrolysis: A comparative QM/MM molecular dynamics analysis for wild type and Y69F mutant retaining xylanasesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Mahmoud E. S. Soliman, J. Javier Ruiz Pernia, Ian R. Greig, Ian H. Williams (Paper from Org. Biomol. Chem.) Mahmoud E. S. Soliman, Org. Biomol. Chem., 2009, DOI: 10.1039/b911644c To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - October 21, 2009 Category: Molecular Biology Authors: Mahmoud E. S. SolimanJ. Javier Ruiz Pernia Ian R. Greig Ian H. Williams Source Type: journals

Hsp-90 and the biology of nematodesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Hsp-90 is a multi-functional protein and the rapid evolution of the hsp-90 gene presumably correlates with other key cellular functions. Factors other than primary amino acid sequence may influence the ability of Hsp-90 to bind to Geldanamycin.
Source: BMC Evolutionary Biology - Latest articles - October 21, 2009 Category: Molecular Biology Authors: Nik HimVictoria GillanRichard EmesKirsty MaitlandEileen Devaney Source Type: journals

Aldose reductase is a potent regulator of TGF-beta1 induced expression of fibronectin in human mesangial cells.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Glomerulosclerosis is considered to be the final pathway leading to the progressive loss of renal function in several kidney diseases, transforming growth factor beta1 (TGF-beta1) plays a critical role in glomerulosclerosis. However, the mechanisms of TGF-beta1 stimulating glomerulosclerosis remain poorly understood. Here we report that TGF-beta1-induced expression of fibronectin (FN) depends on the activity of aldose reductase (AR) in human mesangial cells (HMCs).The results show that TGF-beta1 increased the expression of FN, which attenuated by pharmacological inhibition of AR or knockdown of the enzyme by small inte...
Source: Molecular Biology Reports - October 21, 2009 Category: Molecular Biology Authors: Huang P, Zhang Y, Jiang T, Zeng W, Zhang N Tags: Mol Biol Rep Source Type: journals

Endothelin-1 as a neuropeptide: neurotransmitter or neurovascular effects?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Endothelin-1 (ET-1) is an endothelium-derived peptide that also possesses potent mitogenic activity. There is also a suggestion the ET-1 is a neuropeptide, based mainly on its histological identification in both the central and peripheral nervous system in a number of species, including man. A neuropeptide role for ET-1 is supported by studies showing a variety of effects caused following its administration into different regions of the brain and by application to peripheral nerves. In addition there are studies proposing that ET-1 is implicated in a number of neural circuits where its transmitter affects range from a ...
Source: Journal of Cell Communication and Signaling - October 21, 2009 Category: Molecular Biology Authors: Dashwood MR, Loesch A Tags: J Cell Commun Signal Source Type: journals

Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In conclusion, we herein present a cMSI profile of MSI-H small intestinal adenocarcinomas identifying MARCKS as a frequent target of mutation. Loss of MARCKS protein expression suggests a significant role of MARCKS inactivation in the pathogenesis of small intestinal adenocarcinomas. © 2009 Wiley-Liss, Inc.
Source: Molecular Carcinogenesis - October 21, 2009 Category: Molecular Biology Authors: Sara Michel, Matthias Kloor, Sandhya Singh, Georg Gdynia, Wilfried Roth, Magnus von Knebel Doeberitz, Peter Schirmacher, Hendrik Bläker Source Type: journals

Stromal vascular progenitors in adult human adipose tissueemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The in vivo progenitor of culture-expanded mesenchymal-like adipose-derived stem cells (ADSC) remains elusive, owing in part to the complex organization of stromal cells surrounding the small vessels, and the rapidity with which adipose stromal vascular cells adopt a mesenchymal phenotype in vitro. Immunohistostaining of intact adipose tissue was used to identify three markers (CD31, CD34, and CD146), which together unambiguously discriminate histologically distinct inner and outer rings of vessel-associated stromal cells, as well as capillary and small vessel endothelial cells. These markers were used in multiparameter fl...
Source: Cytometry Part A - October 21, 2009 Category: Molecular Biology Authors: Ludovic Zimmerlin, Vera S. Donnenberg, Melanie E. Pfeifer, E. Michael Meyer, Bruno Péault, J. Peter Rubin, Albert D. Donnenberg Source Type: journals

Carbamate complexation by urea-based receptors: studies in solution and the solid stateemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Peter. R. Edwards, Jennifer. R. Hiscock, Philip. A. Gale, Mark. E. Light (Paper from Org. Biomol. Chem.) Peter. R. Edwards, Org. Biomol. Chem., 2010, DOI: 10.1039/b917140a To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - October 21, 2009 Category: Molecular Biology Authors: Peter. R. EdwardsJennifer. R. Hiscock Philip. A. Gale Mark. E. Light Source Type: journals

Does evolutionary innovation in pharyngeal jaws lead to rapid lineage diversification in labrid fishes?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions The temporal lag between pharyngeal jaw modifications and changes in diversification rates casts doubt on the key innovation hypothesis as a simple explanation for much of the richness seen in labrids and scarines. Although the possession of a secondarily modified PJA was correlated with increased diversification rates, this pattern is better explained by the evolution of extreme dichromatism (and other social and behavioral characters relating to sexual selection) within Scarus and Chlorurus. The PJA-innovation hypothesis also fails to explain the most dominant aspect of labrid lineage diversification, the rad...
Source: BMC Evolutionary Biology - Latest articles - October 21, 2009 Category: Molecular Biology Authors: Michael AlfaroChad BrockBarbara BanburyPeter Wainwright Source Type: journals

Regulation of type 1 diabetes, tuberculosis, and asthma by parasitesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Helminth infection is a worldwide health problem. In addition to directly causing disease, helminthic infection also affects the incidence and progression of other diseases by exerting immune modulatory effects. In animal models, infection with helminthic parasites can prevent autoimmune diseases and allergic inflammatory diseases, but worsens protective immunity to certain infectious pathogens. In this review, we summarize current findings regarding the effects of helminth infection on type 1 diabetes, tuberculosis, and asthma and discuss possible mechanisms through which helminthic parasites modul...
Source: Journal of Molecular Medicine - October 21, 2009 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals

Photolytically generated nitric oxide inhibits caspase activity and results in AIF-mediated cell deathemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  In human skin tissue nitrite is found at relatively high concentrations and represents the main source for cutaneous non-enzymatic nitric oxide (NO) formation during UVA exposure due to photolytical decomposition. Since NO has been repeatedly shown to act pro- as well as anti-apoptotic we here studied the effects of UVA irradiation on human keratinocytes in the presence of nitrite. We show that UVA-induced nitrite photodecomposition effectively inactivated caspase activity. In parallel, we observed in human skin keratinocytes, UVA-irradiated in the presence of nitrite, a proteolytic processing of ap...
Source: Journal of Molecular Medicine - October 21, 2009 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals

Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in miceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  CD4+CD25+ regulatory T cells (Treg), a subpopulation of CD4+ T cells, regulate immune responses. Foxp3 is a key transcription factor for the development and function of Treg cells. During T-cell activation in vitro, a DNA demethylation agent 5-Aza-2′-deoxycytydine (DAC) can induce Foxp3 expression in CD4+CD25− Foxp3− cells via altering methylation status of a conserved element in the 5′-untranslated region of the Foxp3 gene. However, the effects of this agent on the development of Foxp3+ Treg cells in the thymus and in vivo are poorly understood. In the present study, a short-term treatment wit...
Source: Journal of Molecular Medicine - October 21, 2009 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals

Protective effect of Anacardic Acids from Cashew (Anacardium occidentale) on ethanol-induced gastric damage in mice.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Cashew nut-shell liquid and the contained anacardic acids (AAs) have been shown to possess antioxidnt, lipoxygenase inhibitory, anti-Helicobacter pylori and antitumor properties. Despite these known effects, hitherto there were no published reports on their likely gastroprotective effects. The present study was designed to verify whether AAs afford gastroprotection against the ethanol-induced gastric damage and to examine the underlying mechanism(s). Gastric damage was induced by intragastric administration of 0.2mL of ethanol (96%). Mice in groups were pretreated orally with AAs (10, 30 and 100mg/kg), misoprostol (50m...
Source: Chemico-Biological Interactions - October 21, 2009 Category: Molecular Biology Authors: Morais TC, Pinto NB, Carvalho KM, Rios JB, Ricardo NM, Trevisan MT, Rao VS, Santos FA Tags: Chem Biol Interact Source Type: journals

Local anesthetics structure-dependently interact with anionic phospholipid membranes to modify the fluidity.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
While bupivacaine is more cardiotoxic than other local anesthetics, the mechanistic background for different toxic effects remains unclear. Several cardiotoxic compounds act on lipid bilayers to change the physicochemical properties of membranes. We comparatively studied the interaction of local anesthetics with lipid membranous systems which might be related to their structure-selective cardiotoxicity. Amide local anesthetics (10-300muM) were reacted with unilamellar vesicles which were prepared with different phospholipids and cholesterol of varying lipid compositions. They were compared on the potencies to modify me...
Source: Chemico-Biological Interactions - October 21, 2009 Category: Molecular Biology Authors: Tsuchiya H, Ueno T, Mizogami M, Takakura K Tags: Chem Biol Interact Source Type: journals

Comparative study of the oxidation of propranolol enantiomers in hepatic and small intestinal microsomes from cynomolgus and marmoset monkeys.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Oxidative metabolism of propranolol (PL) enantiomers (R-PL and S-PL) to 4-hydroxypropranolol (4-OH-PL), 5-OH-PL and N-desisopropylpropranolol (NDP) was examined in hepatic microsomes from cynomolgus and marmoset monkeys and in small intestinal microsomes from monkeys and humans. In hepatic microsomes, levels of oxidation activities were similar between the two monkey species, and substrate enantioselectivity (R-PL<S-PL) was observed in the formation of 5-OH-PL and/or NDP. Kinetic experiments revealed that the formation of all metabolites was biphasic in cynomolgus monkeys, whereas only the formation of NDP was bipha...
Source: Chemico-Biological Interactions - October 21, 2009 Category: Molecular Biology Authors: Shimizudani T, Nagaoka K, Hanioka N, Yamano S, Narimatsu S Tags: Chem Biol Interact Source Type: journals

Effect of O6-chloroethylguanine DNA lesions on the kinetics and mechanism of micronucleus induction in vivoemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We examined groups of five mice treated with (i) dimethylsulfoxide (DMSO), (ii) O6BG in DMSO, (iii) BCNU, or (iv) O6BG in DMSO plus BCNU. The data indicate that O6BG pretreatment causes: (i) ían increase in MN-PCEs induced by BCNU, (ii) a delay in the time of maximal MN-PCE induction produced by the different BCNU doses, and (iii) an increase in cytotoxicity. These data confirm that O6-ChlEt-G is a lesion involved in DNA break induction and in the subsequent production of micronuclei, and also that these lesions seem to be stoichiometrically reduced by MGMT. These data also show that induction of MN-PCEs by BCNU is delaye...
Source: Environmental and Molecular Mutagenesis - October 20, 2009 Category: Molecular Biology Authors: P. Morales-Ramírez, T. Vallarino-Kelly, V.L. Cruz-Vallejo Source Type: journals

Synthesis and evaluation of fused bispyrimidinoacridines as novel pentacyclic analogues of quadruplex-binder BRACO-19email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Julien Debray, Walid Zeghida, Muriel Jourdan, David Monchaud, Marie-Louise Dheu-Andries, Pascal Dumy, Marie-Paule Teulade-Fichou, Martine Demeunynck (Paper from Org. Biomol. Chem.) Julien Debray, Org. Biomol. Chem., 2009, DOI: 10.1039/b912716j To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - October 20, 2009 Category: Molecular Biology Authors: Julien DebrayWalid Zeghida Muriel Jourdan David Monchaud Marie-Louise Dheu-Andries Pascal Dumy Marie-Paule Teulade-Fichou Martine Demeunynck Source Type: journals

An enantiospecific route towards taiwaniaquinoids. First synthesis of (-)-taiwaniaquinone H and (-)-dichroanoneemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Enrique Alvarez-Manzaneda, Rachid Chahboun, Eduardo Cabrera, Esteban Alvarez, Ali Haidour, Jose Miguel Ramos, Ramon Alvarez-Manzaneda, Yahia Charrah, Hakima Es-Samti (Paper from Org. Biomol. Chem.) Enrique Alvarez-Manzaneda, Org. Biomol. Chem., 2009, DOI: 10.1039/b916209g To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - October 20, 2009 Category: Molecular Biology Authors: Enrique Alvarez-ManzanedaRachid Chahboun Eduardo Cabrera Esteban Alvarez Ali Haidour Jose Miguel Ramos Ramon Alvarez-Manzaneda Yahia Charrah Hakima Es-Samti Source Type: journals

Reactions of 2-(pyrrol-1-yl)benzyl radicals and related species under flash vacuum pyrolysis conditionsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
J. I. G. Cadogan, Bernard A. J. Clark, Daniel Ford, Ranald J. MacDonald, Andrew D. MacPherson, Hamish McNab, Iain S. Nicolson, David Reed, Craig C. Sommerville (Paper from Org. Biomol. Chem.) J. I. G. Cadogan, Org. Biomol. Chem., 2009, DOI: 10.1039/b914965a To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - October 20, 2009 Category: Molecular Biology Authors: J. I. G. CadoganBernard A. J. Clark Daniel Ford Ranald J. MacDonald Andrew D. MacPherson Hamish McNab Iain S. Nicolson David Reed Craig C. Sommerville Source Type: journals

Dual effect of a single nucleotide polymorphism in the first intron of the porcine Secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: At the 3' terminal end of the first intron of the porcine SPP1 we identified a unique, dually functional SNP g.3836A>G. This SNP affects the function of the SPP1 gene at the DNA level by affecting a C/EBP beta binding site and at the RNA level by activating aberrant splicing of the first intron, and thus represents an interesting DNA-marker to study phenotypic effects of SPP1 DNA-variation.
Source: BMC Molecular Biology - Latest articles - October 20, 2009 Category: Molecular Biology Authors: Eduard MuraniSiriluck PonsuksiliHans-Martin SeyfertXuanming ShiKlaus Wimmers Source Type: journals

BioEssays 11/2009email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
No Abstract.
Source: BioEssays - October 20, 2009 Category: Molecular Biology Tags: Contents Source Type: journals

Highlights from this Issueemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
No Abstract.
Source: BioEssays - October 20, 2009 Category: Molecular Biology Tags: Highlights Source Type: journals

The fight for evolution: acceptance through pragmatism?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
No Abstract.
Source: BioEssays - October 20, 2009 Category: Molecular Biology Authors: Andrew Moore Tags: Editorial Source Type: journals

Flower symmetry evolution: towards understanding the abominable mystery of angiosperm radiationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Flower symmetry is considered a morphological novelty that contributed significantly to the rapid radiation of the angiosperms, which already puzzled Charles Darwin and prompted him to name this phenomenon an 'abominable mystery'. In 2009, the bicentenary of Darwin's birth and the 150th anniversary of the publication of his seminal work, 'On the Origin of Species', this question can now be more satisfactorily readdressed. Understanding the molecular control of monosymmetry formation in the model species Antirrhinum opened the path for comparative studies with non-model species revealing modifications of this trait. TCP tra...
Source: BioEssays - October 20, 2009 Category: Molecular Biology Authors: Andrea Busch, Sabine Zachgo Tags: Review articles Source Type: journals