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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 30.

Association of gene polymorphisms with chronic kidney disease in Japanese individuals.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Chronic kidney disease (CKD) is recognized as a risk factor not only for end-stage renal disease but also for cardiovascular disease. Early detection and treatment of CKD is a likely key factor for prevention of its complications. Although genetic linkage analyses and association studies have implicated several loci and candidate genes in predisposition to CKD, the genes that underlie genetic susceptibility to this condition have remained largely unknown. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD in Japanese individuals. The study population comprised 4,829 Japa...
Source: International Journal of Molecular Medicine - September 3, 2009 Category: Molecular Biology Authors: Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y Tags: Int J Mol Med Source Type: journals

Proteins and single nucleotide polymorphisms involved in apoptosis, growth control, and DNA repair predict cisplatin sensitivity in head and neck cancer cell lines.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The present study was undertaken to evaluate the possibility of using a panel of proteins and single nucleotide polymorphisms (SNPs) involved in apoptosis, growth control, and DNA repair as predictive markers for cisplatin sensitivity. For this purpose the intrinsic cisplatin sensitivity (ICS) was determined in 39 cell lines derived from squamous cell carcinomas of the head and neck using a colony-forming assay. In these cell lines and in normal oral keratinocytes (NOK), the expression of epidermal growth factor receptor (EGFR), Hsp70, Bax, Bcl-2, Bcl-XL, survivin, and COX-2 was determined. Moreover, the p53, MDM2, FGF...
Source: International Journal of Molecular Medicine - September 3, 2009 Category: Molecular Biology Authors: Farnebo L, Jedlinski A, Ansell A, Vainikka L, Thunell LK, Grénman R, Johansson AC, Roberg K Tags: Int J Mol Med Source Type: journals

Annexin A2 mediates anti-beta2GPI/beta2GPI-induced tissue factor expression on monocytes.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In conclusion, these results indicate that ANX2 on cell surface functions as a mediator boosting TF expression on monocytes induced by anti-beta2GPI/beta2GPI complex, which is contributed to the thrombotic events in APS. PMID: 19724897 [PubMed - in process]
Source: International Journal of Molecular Medicine - September 3, 2009 Category: Molecular Biology Authors: Zhou H, Wang H, Li N, Yu Y, Huang H, Yan Y, Wang T Tags: Int J Mol Med Source Type: journals

Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CpG island hyper-methylation (CIHM) is one of the major events in the gastric carcinogenesis and also occurs in non-neoplastic gastric mucosa. IL-17A, -17F and MIF have a crucial role in the gastric inflammationand carcinogenesis. The CIHM status in the non-cancerous gastric mucosa, in relation to IL-17A (-197G>A, rs2275913), -17F (7488T>C, rs763780) and MIF (-173G>C and -794 tetranucleotide repeats) polymorphisms was investigated. Gastric mucosa samples were obtained from 121 cancer free subjects. CIHM of p14, p16, DAP-kinase and CDH1 genes were determined by methylation-specific polymerase chain reaction (MS...
Source: International Journal of Molecular Medicine - September 3, 2009 Category: Molecular Biology Authors: Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, Yonemura J, Maeda Y, Maruyama N, Kamano T, Kamiya Y, Fujita H, Nakagawa Y, Nagasaka M, Iwata M, Hirata I, Arisawa T Tags: Int J Mol Med Source Type: journals

Coptis chinensis inhibits hepatocellular carcinoma cell growth through nonsteroidal anti-inflammatory drug-activated gene activation.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conventional chemotherapy of liver cancer fails to provide satisfactory remission and may cause serious side effects, thus it is crucial to derive alternative treatments that effectively inhibit cancer cell growth with known mechanisms of action. In the present study, we investigated the anti-carcinogenic effects of Coptis chinensis and its major constituent, berberine, in HepG2 hepatocellular carcinoma (HCC) cells and attempted to elucidate the underlying mechanism, including involvement of the nonsteroidal anti-inflammatory drug (NSAID)-activated gene (NAG-1). Inhibition of cell proliferation, induction of apoptosis ...
Source: International Journal of Molecular Medicine - September 3, 2009 Category: Molecular Biology Authors: Auyeung KK, Ko JK Tags: Int J Mol Med Source Type: journals

Pro- and anti-inflammatory cytokines increase hyaluronan production by rat synovial membrane in vitro.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Synovial membrane consists of fibroblasts and macrophages forming the synovial lining supported by vascularized subsynovium. Each of these components may specifically react to a particular stimulus. Thus, reactions of isolated synovial cells may not correspond to that of intact tissue. We characterized the production of hyaluronan (HA) by rat synovial membrane exposed in vitro to pro- and anti-inflammatory cytokines and compared it with previous results obtained with isolated fibroblasts. Synovial membrane dissected from one knee joint served as a control to that from the opposite knee exposed to IL-1beta, TGF-beta1, T...
Source: International Journal of Molecular Medicine - September 3, 2009 Category: Molecular Biology Authors: Hyc A, Osiecka-Iwan A, Niderla-Bielinska J, Jankowska-Steifer E, Moskalewski S Tags: Int J Mol Med Source Type: journals

Tumor necrosis factor-alpha participates in apoptosis in the limbic system after myocardial infarctionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study was designed to determine the role of tumor necrosis factor-alpha (TNFα) in apoptosis observed in the myocardium and limbic system after myocardial ischemia. PEG sTNFRI, a recombinant, human, soluble p55 Type 1 TNF receptor (3 mg/kg) or vehicle (saline) was administered s.c. to male Sprague-Dawley rats on days 5, 3 and 1 before myocardial ischemia. The animals were then subjected, under anesthesia, to left anterior descending coronary artery occlusion for 40 min, followed by 15-min or 72-h reperfusion. Caspase-3 and -8 activities as well as terminal dUTP nick-end labelling-positive cells were exam...
Source: Apoptosis - September 3, 2009 Category: Molecular Biology Tags: Apoptosis Source Type: journals

Letter to the Editoremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s11307-009-0254-8Authors Victor H. Gerbaudo, Harvard Medical School Division of Nuclear Medicine and Molecular Imaging, Brigham & Women’s Hospital Boston MA USAScott Britz-Cunningham, Harvard Medical School Division of Nuclear Medicine and Molecular Imaging, Brigham & Women’s Hospital Boston MA USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632
Source: Molecular Imaging and Biology - September 3, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Colon cancer stem cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Colorectal cancer (CRC) is the third most common form of cancer and the second cause of cancer-related death in the Western world, leading to 655,000 deaths worldwide per year (Jemal et al. in CA Cancer J Clin 56:106–130, 2006). Despite the emergence of new targeted agents and the use of various therapeutic combinations, none of the treatment options available is curative in patients with advanced cancer. A growing body of evidence is increasingly supporting the idea that human cancers can be considered as a stem cell disease. According to the cancer stem cell model, malignancies originate from a ...
Source: Journal of Molecular Medicine - September 3, 2009 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: journals

Theoretical models of spontaneous activity generation and propagation in the developing retinaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Keith B. Godfrey, Stephen J. Eglen (Review from Mol. BioSyst.) Keith B. Godfrey, Mol. BioSyst., 2009, DOI: 10.1039/b907213f To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Mol. BioSyst. latest articles - September 2, 2009 Category: Molecular Biology Authors: Keith B. GodfreyStephen J. Eglen Source Type: journals

Correlation between mRNA expression levels and protein aggregation propensities in subcellular localisationsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Gian Gaetano Tartaglia, Michele Vendruscolo (Paper from Mol. BioSyst.) Gian Gaetano Tartaglia, Mol. BioSyst., 2009, DOI: 10.1039/b913099n To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Mol. BioSyst. latest articles - September 2, 2009 Category: Molecular Biology Authors: Gian Gaetano TartagliaMichele Vendruscolo Source Type: journals

Of proteins and DNA-proteomic role in the field of chromatin researchemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Jean-Philippe Lambert, Kristin Baetz, Daniel Figeys (Review from Mol. BioSyst.) Jean-Philippe Lambert, Mol. BioSyst., 2009, DOI: 10.1039/b907925b To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Mol. BioSyst. latest articles - September 2, 2009 Category: Molecular Biology Authors: Jean-Philippe LambertKristin Baetz Daniel Figeys Source Type: journals

Thermodynamic forecasting of mechanically interlocked switchesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Mark A. Olson, Adam B. Braunschweig, Taichi Ikeda, Lei Fang, Ali Trabolsi, Alexandra M. Z. Slawin, Saeed I. Khan, J. Fraser Stoddart (Paper from Org. Biomol. Chem.) Mark A. Olson, Org. Biomol. Chem., 2009, DOI: 10.1039/b911874h To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - September 2, 2009 Category: Molecular Biology Authors: Mark A. OlsonAdam B. Braunschweig Taichi Ikeda Lei Fang Ali Trabolsi Alexandra M. Z. Slawin Saeed I. Khan J. Fraser Stoddart Source Type: journals

Ni and Pd mediate asymmetric organoboron synthesis with ester functionality at the [small beta]-positionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Vanesa Lillo, Michael J. Geier, Stephen A. Westcott, Elena Fernandez (Paper from Org. Biomol. Chem.) Vanesa Lillo, Org. Biomol. Chem., 2009, DOI: 10.1039/b909341a To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - September 2, 2009 Category: Molecular Biology Authors: Vanesa LilloMichael J. Geier Stephen A. Westcott Elena Fernandez Source Type: journals

Biocatalytic oxidation by chloroperoxidase from Caldariomyces fumago in polymersome nanoreactorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
H. M. de Hoog, M. Nallani, J. J. L. M. Cornelissen, A. E. Rowan, R. J. M. Nolte, I. W. C. E. Arends (Paper from Org. Biomol. Chem.) H. M. de Hoog, Org. Biomol. Chem., 2009, DOI: 10.1039/b911370c To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - September 2, 2009 Category: Molecular Biology Authors: H. M. de HoogM. Nallani J. J. L. M. Cornelissen A. E. Rowan R. J. M. Nolte I. W. C. E. Arends Source Type: journals

Sensing of peptide hormones with dynamic combinatorial libraries of metal-dye complexes: the advantage of time-resolved measurementsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Friederike Zaubitzer, Thomas Riis-Johannessen, Kay Severin (Paper from Org. Biomol. Chem.) Friederike Zaubitzer, Org. Biomol. Chem., 2009, DOI: 10.1039/b912400d To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - September 2, 2009 Category: Molecular Biology Authors: Friederike ZaubitzerThomas Riis-Johannessen Kay Severin Source Type: journals

Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathwayemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Zhi-yong Tian, Song-qiang Xie, Zi-hou Mei, Jin Zhao, Wen-yuan Gao, Chao-jie Wang (Paper from Org. Biomol. Chem.) Zhi-yong Tian, Org. Biomol. Chem., 2009, DOI: 10.1039/b912685f To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - September 2, 2009 Category: Molecular Biology Authors: Zhi-yong TianSong-qiang Xie Zi-hou Mei Jin Zhao Wen-yuan Gao Chao-jie Wang Source Type: journals

Determination of critical size defect of minipig mandibleemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The critical size defect (CSD) of bone can provide a standard for evaluating the usefulness of bone repair materials or methods. The present study aimed to determine the CSDs of the minipig mandible with and without the periosteum. Ten 18 month-old female minipigs were used. First, the premolars and the first molar in the right mandible of each minipig were extracted. Two months later, the animals were randomly divided into two groups, with six animals in group A and four in group B. In group A, bone segments of 4, 5 and 6 cm were removed from the right mandible and the neighbouring periosteum was preserved. In group B, bo...
Source: Journal of Tissue Engineering and Regenerative Medicine - September 2, 2009 Category: Molecular Biology Authors: Jin-Ling Ma, Ju-Li Pan, Bao-Sheng Tan, Fu-Zhai Cui Source Type: journals

The effective expression of xylanase gene in Candida utilis by 18S rDNA targeted homologous recombination in pGLR9K.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In order to test whether 18S rDNA can influence positively xylanase gene effective expression in the yeast of Candida utilis, a targeting vector pGLR9K-XA was constructed by adding an interested gene xynA from Streptomyces olivaceoviridis into the vector pGLR9K which is constructed by ourselves. pGLR9K contains the 18S rDNA, GAP promoter and CYH resistance gene sequence, all of which is from C. utilis. Then the vector pGLR9K-XA was transformed into C. utilis. To test the vector and transformed system, PCR, Southern blot and DNS methods were used. The results showed that xylanase gene can be detected in the chromosome D...
Source: Molecular Biology Reports - September 2, 2009 Category: Molecular Biology Authors: Wei W, Hong-Lan Y, Huifang B, Daoyuan Z, Qi-Mu-Ge S, Wood AJ Tags: Mol Biol Rep Source Type: journals

A proteomic study of the response to salinity and drought stress in an introgression strain of bread wheat.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The effect of drought and salinity stress on the seedlings of the somatic hybrid wheat cv. Shanrong No. 3 (SR3) and its parent bread wheat cv. Jinan 177 (JN177) was investigated using two dimensional gel electrophoresis and mass spectrometry. Out of a set of 93 (root) and 65 (leaf) differentially expressed proteins (DEPs), 34 (root) and six (leaf) DEPs were cultivar-specific. The remaining DEPs were salinity/drought stress responsive, but not cultivar-specific. Many of the DEPs were expressed under both drought and salinity stress. The amounts of stress responsive DEPs between SR3 and JN177 were almost equivalent, wher...
Source: Molecular and Cellular Proteomics : MCP - September 2, 2009 Category: Molecular Biology Authors: Peng Z, Wang M, Li F, Lv H, Li C, Xia G Tags: Mol Cell Proteomics Source Type: journals

MYST family histone acetyltransferases take center stage in stem cells and developmentemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Acetylation of histones is an essential element regulating chromatin structure and transcription. MYST (Moz, Ybf2/Sas3, Sas2, Tip60) proteins form the largest family of histone acetyltransferases and are present in all eukaryotes. Surprisingly, until recently this protein family was poorly studied. However, in the last few years there has been a substantial increase in interest in the MYST proteins and a number of key studies have shown that these chromatin modifiers are required for a diverse range of cellular processes, both in health and disease. Translocations affecting MYST histone acetyltransferases can lead to leuke...
Source: BioEssays - September 1, 2009 Category: Molecular Biology Authors: Anne K. Voss, Tim Thomas Source Type: journals

Genome-scale modeling and in silico analysis of mouse cell metabolic networkemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Suresh Selvarasu, Iftekhar A. Karimi, Ghi-Hoon Ghim, Dong-Yup Lee (Paper from Mol. BioSyst.) Suresh Selvarasu, Mol. BioSyst., 2009, DOI: 10.1039/b912865d To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Mol. BioSyst. latest articles - September 1, 2009 Category: Molecular Biology Authors: Suresh SelvarasuIftekhar A. Karimi Ghi-Hoon Ghim Dong-Yup Lee Source Type: journals

Design of a [small beta]-hairpin peptide-intercalator conjugate for simultaneous recognition of single stranded and double stranded regions of RNAemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Lauren L. Cline, Marcey L. Waters (Paper from Org. Biomol. Chem.) Lauren L. Cline, Org. Biomol. Chem., 2009, DOI: 10.1039/b913024a To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - September 1, 2009 Category: Molecular Biology Authors: Lauren L. ClineMarcey L. Waters Source Type: journals

The acyl nitroso Diels-Alder (ANDA) reaction of sorbate derivatives: an X-ray and 15N NMR study with an application to amino-acid synthesisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Lee Bollans, John Bacsa, Jonathan A. Iggo, Gareth A. Morris, Andrew V. Stachulski (Paper from Org. Biomol. Chem.) Lee Bollans, Org. Biomol. Chem., 2009, DOI: 10.1039/b912963d To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic Biomolecular Chemistry - September 1, 2009 Category: Molecular Biology Authors: Lee BollansJohn Bacsa Jonathan A. Iggo Gareth A. Morris Andrew V. Stachulski Source Type: journals

Multigene expression of protein complexes by iterative modification of genomic Bacmid DNAemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: 1. Use of bipartite selections can significantly improve selection of modified bacterial artificial chromosomes carrying baculovirus DNA. Furthermore this approach is sufficiently robust to allow routine modification of the virus genome. 2. In addition to the commonly used p10 and polyhedrin loci, the ctx, egt, 39k, orf51, gp37, iap2 and odv-e56 loci in AcMNPV are all suitable for the high level expression of heterologous genes. 3. Two protein, four protein and eight protein complexes including virus-like particles and cellular chaperone complexes can be produced using the new approach.
Source: BMC Molecular Biology - Latest articles - September 1, 2009 Category: Molecular Biology Authors: Rob NoadMeredith StewartMark BoyceCristina CelmaKeith WillisonPolly Roy Source Type: journals

The metallomics approach: use of Fe(ii) and Cu(ii) footprinting to examine metal binding sites on serum albuminsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Michael R. Duff, Jr., Challa V. Kumar (From Metallomics) Michael R. Duff, Jr., Metallomics, 2009, DOI: 10.1039/b910253a To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chemical Biology Virtual Journal latest articles - September 1, 2009 Category: Molecular Biology Authors: Michael R. Duff, Jr.Challa V. Kumar Source Type: journals

Pseudo-halide derivatives of titanocene Y: synthesis and cytotoxicity studiesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
James Claffey, Anthony Deally, Brendan Gleeson, Megan Hogan, Luis Miguel Menendez Mendez, Helge Muller-Bunz, Siddappa Patil, Denise Wallis, Matthias Tacke (From Metallomics) James Claffey, Metallomics, 2009, DOI: 10.1039/b911753a To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chemical Biology Virtual Journal latest articles - September 1, 2009 Category: Molecular Biology Authors: James ClaffeyAnthony Deally Brendan Gleeson Megan Hogan Luis Miguel Menendez Mendez Helge Muller-Bunz Siddappa Patil Denise Wallis Matthias Tacke Source Type: journals

Novel SNPs of the bovine GAD1/gad67 gene and their association with growth traits in three native Chinese cattle breeds.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study, polymorphism in the exon 1, 2, 3, 4 and 5 of bovine GAD1 gene was detected by PCR-SSCP and DNA sequencing methods in 726 individuals from three Chinese cattle breeds. Two haplotypes (T and C) and three observed genotypes (TT, TC, and CC) were detected. The result of DNA sequence showed one mutations (T12345C) by comparisons with NC_007300: g.12345T>C. The mutation was at the exon 3, and was identified a missense mutation Phe (TTT)>Leu (CTT) at position 51 (p.F51L). Polymorphism of the GAD1 gene was shown to be associated with growth traits in the Nanyang breed. The SNP in the bovine GAD1 gene had signi...
Source: Molecular Biology Reports - September 1, 2009 Category: Molecular Biology Authors: Li F, Chen H, Lei CZ, Ren G, Wang J, Li ZJ, Wang JQ Tags: Mol Biol Rep Source Type: journals

Impact of BTG2 expression on proliferation and invasion of gastric cancer cells in vitro.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BTG2 (B cell translocation gene 2) is downregulated in several human tumors and has been known as a tumor suppressor in carcinogenesis of thymus, prostate, kidney, and liver. However, little is known about the role BTG2 plays in gastric adenocarcinoma. In the present study, we intended to investigate the influence of BTG2 on the growth, proliferation, apoptosis, invasion and cell cycle of the gastric cancer cell lines SGC7901 and MKN45. BTG2 cDNA was insected into a constitutive vector pcDNA3.1 followed by transfection in gastric cancer cell line MKN45 and SGC7901 by using liposome. Then stable transfectants were selec...
Source: Molecular Biology Reports - September 1, 2009 Category: Molecular Biology Authors: Zhang L, Huang H, Wu K, Wang M, Wu B Tags: Mol Biol Rep Source Type: journals

Identification and characteristics of a novel gene, EJO1, in the Chinese mitten crab (Eriocheir japonica sinensis) ovary.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In conclusion, EJO1 is a novel gene differentially expressed in the ovary of the Chinese mitten crab, which may play an important role in the ovary development. PMID: 19728148 [PubMed - as supplied by publisher]
Source: Molecular Biology Reports - September 1, 2009 Category: Molecular Biology Authors: Ma C, Guo Y, Zhou K Tags: Mol Biol Rep Source Type: journals

Kei1: a Novel Subunit of Inositolphosphorylceramide Synthase, Essential for Its Enzyme Activity and Golgi Localization.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Monitoring Editor: Sean Munro Fungal sphingolipids have inositol-phosphate head groups, which are essential for the viability of cells. These head groups are added by inositol phosphorylceramide (IPC) synthase, and AUR1 has been thought to encode this enzyme. Here we show that an essential protein encoded by KEI1 is a novel subunit of IPC synthase of S. cerevisiae. We find that Kei1 is localized in the medial Golgi and that Kei1 is cleaved by Kex2, a late Golgi processing endopeptidase; therefore it recycles between the medial and late Golgi compartments. The growth defect of kei1-1, a temperature-sensitive mutant, is ...
Source: Mol Biol Cell - September 1, 2009 Category: Molecular Biology Authors: Sato K, Noda Y, Yoda K Tags: Mol Biol Cell Source Type: journals

CASK Deletion in Intestinal Epithelia Causes Mislocalization of LIN7C and the DLG1/Scrib Polarity Complex without Affecting Cell Polarity.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Monitoring Editor: Asma Nusrat CASK is the mammalian ortholog of LIN2, a component of the LIN2/7/10 protein complex that targets epidermal growth factor receptor (EGFR) to basolateral membranes in C. elegans. A member of the MAGUK family of scaffolding proteins, CASK resides at basolateral membranes in polarized epithelia. Its interaction with LIN7 is evolutionarily conserved. In addition, CASK forms a complex with another MAGUK, the DLG1 tumor suppressor. Although complete knockout of CASK is lethal, the gene is X-linked, enabling us to generate heterozygous female adults that are mosaic for its expression. We also ge...
Source: Mol Biol Cell - September 1, 2009 Category: Molecular Biology Authors: Lozovatsky L, Abayasekara N, Piawah S, Walther Z Tags: Mol Biol Cell Source Type: journals

The TGF-{beta} Type III Receptor Mediates Distinct Subcellular Trafficking and Downstream Signaling of ALK3 and ALK6 Receptors.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Monitoring Editor: Kunxin Luo Bone morphogenetic proteins (BMPs) signal through the BMP type I and type II receptors to regulate cellular processes, including embryonic development. The type I BMP receptors ALK3 and ALK6 share a high degree of homology, yet possess distinct signaling roles. Here, we report that while the transforming growth factor-beta (TGFbeta) type III receptor (TbetaRIII) enhanced both ALK3 and ALK6 signaling, TbetaRIII more potently enhanced ALK6-mediated stimulation of the BMP-responsive promoters, XVent2 and 3GC2, and upregulation of the early response gene, Smad6. In contrast, TbetaRIII specific...
Source: Mol Biol Cell - September 1, 2009 Category: Molecular Biology Authors: Lee NY, Kirkbride KC, Sheu RD, Blobe GC Tags: Mol Biol Cell Source Type: journals

Myometrial interstitial cells and the coordination of myometrial contractility.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract A strict regulation of contractility in the uterus and fallopian tube is essential for various reproductive functions. The uterus contributes, through either increased contractility or periods of relative quiescence, to: (a) expulsion of menstrual debris; (b) sperm transport; (c) adequate embryo placement during implantation; (d) enlarging its capacity during pregnancy; (e) parturition. The dominant cell population of the uterine wall consists of smooth muscle cells that contain the contractile apparatus responsible for the generation contractile force. Recent interest has focused on a new population of cells ...
Source: J Cell Mol Med - September 1, 2009 Category: Molecular Biology Authors: Hutchings G, Williams O, Cretoiu D, Ciontea SM Tags: J Cell Mol Med Source Type: journals

Vascular calcification and bone disease: the calcification paradox.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Vascular calcification or ectopic mineralization in blood vessels is an active, cell-regulated process, increasingly recognized as a general cardiovascular risk factor. Remarkably, ectopic artery mineralization is frequently accompanied by decreased bone mineral density or disturbed bone turnover. This contradictory association, observed mainly in osteoporosis and chronic kidney disease, is called the 'calcification paradox'. Here, we review recent advances in our understanding of the calcification paradox, including protein expression patterns governing both normal and ectopic mineralization, the conversion of vascula...
Source: Trends in Molecular Medicine - September 1, 2009 Category: Molecular Biology Authors: Persy V, D'Haese P Tags: Trends Mol Med Source Type: journals

Differential transcriptional modulation of duplicated fatty acid-binding protein genes by dietary fatty acids in zebrafish (Danio rerio): evidence for subfunctionalization and neofunctionalization of duplicated genesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Differential induction of only one of the sister pair of duplicated fabp genes by FAs provides evidence to support the DDC model for retention of duplicated genes in the zebrafish genome by either subfunctionalization or neofunctionalization.
Source: BMC Evolutionary Biology - Latest articles - September 1, 2009 Category: Molecular Biology Authors: Santhosh KaranthSantosh LallEileen Denovan-WrightJonathan Wright Source Type: journals

[Reconstructing genes evolution along a species tree]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: A model and algorithm are proposed to infer evolution of a gene family, given the gene tree, with respect to species evolution, given the species tree. The model describes such evolution using the "nested tree" concept. Performance of the algorithm is verified on several orthologous protein groups. The evolutionary events inferred are: speciation, gene duplication and loss, horizontal gene transfer retaining the original gene copy. A transfer event with the loss of original gene copy is considered a combination of gene transfer and loss. The model maps gene evolution events onto the species phylogeny. PMI...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Complex analysis of genetic predisposition to ischemic stroke in Russians]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: Carriage frequencies of alleles and genotypes of 10 functionally important single nucleotide polymorphisms that are located in genes FGA, FGB, APOE, LPL, ACE and CMA1 were analyzed in the ischemic stroke (IS) patients of Russian ethnic descent and in the control group of the same ethnic descent and of similar gender and age. Comparison between patients and control group revealed no significant differences in frequencies of individual alleles and genotypes for all the polymorphic loci studied. However, complex analysis of genetic predisposition using APSampler algorithm revealed carriage of allele (-491A) APOE...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Evolution aspects of intraspecific polymorphysm of Arabidopsis thaliana genes coding subunit I of Mg-chelatase complex]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: Intraspecific polymorphism in the CHLI 2 gene, coding subunit I of Mg-chelatase complex that forms Mg-protoporphyrin IX was investigated in 19 ecotypes of Arabidopsis thaliana. Sequence divergence by 35 nucleotides was found; 12 of them result into amino acid change in third exon where functional domains of the protein are located. In one of two found divergent sequence haplogroups, Col haplogroup an excess of low-frequency polymorphism was revealed, showing the action of purifying selection and indicating a functional significance of CHLI 2 gene. Paths of evolutionary dynamics for CHLI 1 and CHLI 2 genes det...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Genetic structure of walleye pollock Theragra chalcogramma (Gadidae, Pisces) from Bering Sea and Sea of Okhotsk]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: The genetic population structure in 4 spawning aggregations from the Bering Sea of walleye pollock (Theragra chalcogramma, Pallas), that occupies a central place in ecosystems of the North Pacific and is an important object of fisheries, was investigated with the ten microsatellite loci Tch5, Tch10, Tch11, Tch12, Tch14, Tch16, Tch17, Tch19, Tch20 and Tch22. The spatially distanced sample from Sea of Okhotsk was a referent group. The polymorphism of the markers used accounted for 100%, heterozygozity ranged from 41 to 95% in the different populations. It was shown that the aggregations of interest are in goodn...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Comparative phylogeography: molecular methods, ecological interpretation]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: This brief review of phylogeohraphy - the new field of study concerned with the principles and processing governing the geographic distribution of genealogical lineages (mainly within and among closely related species), is focused on the importance of the ecological approach in understanding of the molecular-genetic data. The comparative phylogeohraphy as one of the most promising lines of investigation in this respect is considered. Comparisons of the phylogeohraphical patterns and ecological traits of representatives of separate ecosystems, regional faunas, systematically close species, "host-parasite" comp...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Supraspecies relationships in the subfamily (Rodentia, Cricetidae, Arvicolinae): unexpexted result of nuclear genes analysis]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: Phylogenetic analysis of supraspecies relationships in one of the most young and species rich group of myomorph rodents - subfamily Arvicolinae was carried out on the base of two nuclear genes. Results have shown that mole-voles - Ellobiusini, steppe voles - (Lagurini) and grey voles (Arvicolini) are sister groups. This divergence is the most late, third wave of radiation within the family. The sister clade to this group is the tribe of red-back voles - Myodini (=Clethrionomini) - "second radiation". The order of divergence for earliest radiation remains still unresolved (Ondatrini, Prometheomyini, Dicrostony...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Current view on tetrapod's origin and diversification]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: For the last few decades a wealth of evidence have been obtained (including new fossils, and new nucleotide sequences) which provide a way of revising the current evolutionary theories. The primary structures of a number of orthological regions from a variety of genomes have been evaluated. Full sized genomic sequences for some organisms, have been detected. This review is devoted to modern concepts of the tetrapod's rise and diversification, and of the contemporary vertebrates' class formation. PMID: 19899635 [PubMed - in process]
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[On the phylogenetic position of Hexapoda within the Pancrustacea]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: Contemporary views on the phylogeny of arthropods are at odds with the traditional system, which recognizes four independent arthropod classes: Chelicerata, Crustacea, Myriapoda and Insecta. There is compelling evidence that insects in fact comprise a monophyletic lineage with Crustacea within a larger clade of Pancrustacea (=Tetraconata). Which crustacean group is the closest living relative of insects remains an open question. Recent phylogenetic analyses based on multiple genes suggest their sistership with "lower" crustaceans, the Branchiopoda. This relationship was often impeached to be caused by the lon...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Molecular phylogeny and systematics of flowering plants of the family Crassulaceae DC]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: Crassulaceae is the most species rich (ca. 1400) family in the order Saxifragales. Most members of the family are succulent plants. Phenotypic diversity and a large number of species complicate systematics of the family and reconstruction of relationship within it. Phylogenetic analyses based on morphological and molecular markers placed Crassulaceae as one of the crown clades of Saxifragales. In this contribution a review of phylogenetic studies of the family Crassulaceae, based on DNA nucleotide sequence comparisons is presented; major clades established in the family are characterised; their structure and ...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Genosystematics and new insight on phylogeny and taxonomy of liverworts]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: The paper covers a current state of molecular studies of liverworts including new data from authors. The traditional conceptions of liverwort phylogeny and systematics were changed greatly in a result of recent molecular researches. The phylogenetic inferences from studies of different DNA loci and species sampling are mainly congruent. The phylogeny and systematics of one of the largest and taxonomically difficult suborder Jungermaniineae was discussed based on analyses of internal transcribed spacer ITS1-2 of nuclear rDNA and chloroplast trnL-F of large species number. PMID: 19899632 [PubMed - in process]
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Evolution of the phosphofructokinase gene introne in gastropods of family Baicaliidae]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: One of the intrones of the phosphofructokinase gene has been sequenced in seven species of endemic Baikalian gastropods of family Baicaliidae. The length of this introne differs even between sister species. Along with relatively few nucleotide substitutions numerous deletions and insertions accumulated. The number of deletions/insertions does not correlate to genetic distance between the species as estimated by comparing sequences of a mitochondrial fragment. Deduced tertiary structure differs markedly even between sister taxa although there is a consensus motif. Long RNA stems appearing and disappearing in c...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Structure characteristics of the chloroplast rpS16 intron in Allium sativum and related Allium species]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: For the first time the chloroplast rpS16 intron sequences in A. sativum accessions with different ecologo-geographical origins and related Allium species have been characterized. The main stem-loop consensus sequences and boundaries ofsix domains have been identified and the most probable secondary structure model of the intron pre-RNA has been predicted. Allium rpS16 introns have been characterized by mutation rate heterogeneity between structure regions of all six domains. Domains II and IV of the intron are shown to be more variable with transition predominance in I, III, V and VI domain sequences. In addi...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Structure and evolution of junctions between inverted repeat and small single copy regions of chloroplast genome in non-core Caryophyllales]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: The structure of junction between inverted repeat (IR) and small single copy (SSC) regions of chloroplast genome in the representatives of non-core Caryophyllales is investigated in this work. It was found that for two families - Polygonaceae and Plumbaginaceae - the extension of inverted region is characteristic. This extension is due to the duplication the part of ycf1 gene that is partly located in the small single copy region in plants with typical structure of IR/SSC junctions. Comparison of the position of IR/SSC junctions in different species of Polygonaceae has shown that their exact position is not c...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals

[Molecular phylogeny and systematics of Drosophila retrotransposons and retroviruses]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Authors: Full classification of Drosophila melanogaster retrotransposons with long terminal repeats (LTR-retrotransposons) has been recomposed, and their evolutional analysis in sequenced genomes of different species of drosophila and other arthropods has been carried out. D. melanogaster LTR-retrotransposons are divided in three groups: gypsy (one, two or three open reading frames - ORFs), copia (one ORF), BEL (one ORF). Gypsy group is divided into three subgroups. Subgroup I is underrepresented by retrotransposons-retroviruses with three ORFs and their derivatives which have lost the env gene (ORF3). Subgroup II is ...
Source: Molekuliarnaia Biologiia - September 1, 2009 Category: Molecular Biology Tags: Mol Biol (Mosk) Source Type: journals