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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications (review).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ghrelin is a peptide hormone, which has been isolated from the stomach. It is localized mostly in endocrine cells in the oxyntic mucosa of the stomach. Ghrelin receptors are expressed equally in all parts of the gastrointestinal tract, with a similar level of expression in the mucosal and muscle layers. This peptide hormone has several functions, the most widely known is its growth hormone (GH)-releasing effect. Ghrelin plays an important role in regulating appetite, feeding and energy metabolism. It also plays a role in mediating immune response and inflammatory processes. Ghrelin stimulates gastric motility and empty...
Source: International Journal of Molecular Medicine - November 5, 2009 Category: Molecular Biology Authors: El-Salhy M Tags: Int J Mol Med Source Type: journals

Experimental study of the anti-cancer mechanism of tanshinone IIA against human breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was performed to determine the anti-cancer activity of tanshinone IIA on human breast cancer cells in vitro and in vivo and to elucidate the underlying mechanism of this activity. Human breast cancer cell lines (estrogen receptor-positive and -negative) were treated with tanshinone IIA and tamoxifen. The inhibitory effects of tanshinone IIA and tamoxifen on breast cancer cell proliferation were examined using MTT assays, BrdU incorporation, immunohistochemistry and flow cytometry. Upon treatment with tanshinone IIA, breast cancer cell proliferation was significantly inhibited in a dose- and time-dependent manner...
Source: International Journal of Molecular Medicine - November 5, 2009 Category: Molecular Biology Authors: Lu Q, Zhang P, Zhang X, Chen J Tags: Int J Mol Med Source Type: journals

Neuronal and BBB damage induced by sera from patients with secondary progressive multiple sclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An important component of the pathogenic process of multiple sclerosis (MS) is the blood-brain barrier (BBB) damage. We recently set an in vitro model of BBB, based on a three-cell-type co-culture system, in which rat neurons and astrocytes synergistically induce brain capillary endothelial cells to form a monolayer with permeability properties resembling those of the physiological BBB. Herein we report that the serum from patients with secondary progressive multiple sclerosis (SPMS) has a damaging effect on isolated neurons. This finding suggests that neuronal damaging in MS could be a primary event and not only secon...
Source: International Journal of Molecular Medicine - November 5, 2009 Category: Molecular Biology Authors: Proia P, Schiera G, Salemi G, Ragonese P, Savettieri G, Di Liegro I Tags: Int J Mol Med Source Type: journals

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tae-gyu Nam, Susheel J. Nara, Irene Zagol-Ikapitte, Thomas Cooper, Luca Valgimigli, John A. Oates, Ned A. Porter, Olivier Boutaud, Derek A. Pratt (Paper from Org. Biomol. Chem.) Tae-gyu Nam, Org. Biomol. Chem., 2009, DOI: 10.1039/b912528k To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - October 19, 2009 Category: Molecular Biology Authors: Tae-gyu NamSusheel J. Nara Irene Zagol-Ikapitte Thomas Cooper Luca Valgimigli John A. Oates Ned A. Porter Olivier Boutaud Derek A. Pratt Source Type: journals

Antibody-based therapy of leukaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Review ArticlesJohn C. Morris, Thomas A. Waldmann, Expert Reviews in Molecular Medicine, Volume 11 , pp e29AbstractOver the past decade, monoclonal antibodies have dramatically impacted the treatment of haematological malignancies, as evidenced by the effect of rituximab on the response rate and survival of patients with follicular and diffuse large B cell non-Hodgkin's lymphoma. Currently, only two monoclonal antibodies are approved for treatment of relapsed acute myeloid leukaemia in older patients and B cell chronic lymphocytic leukaemia, respectively. Although not approved for such treatment, alemtuzumab is also activ...
Source: Expert Reviews in Molecular Medicine - September 30, 2009 Category: Molecular Biology Source Type: journals

Chronic myelogenous leukemia and benzene exposure: a systematic review and meta-analysis of the case-control literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds r...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Lamm SH, Engel A, Joshi KP, Byrd DM, Chen R Tags: Chem Biol Interact Source Type: journals

Changes in the expression of cholesterol metabolism-associated genes in HCV-infected liver: a novel target for therapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we evaluated the expression of lipid metabolism-associated genes in patients with HCV infection by real-time PCR. Sterol regulatory element-binding protein (SREBP)-2 expression was unchanged and low density lipoprotein receptor expression was markedly reduced by 90% in HCV-infected liver. The expression of apolipoprotein B100, microsomal triglyceride transfer protein and ATP-binding cassette G5 was significantly increased. Up-regulation of cholesterol synthesis-associated genes, including HMG-CoA reductase, HMG-CoA synthase, farnesyl-diphosphate synthase and squalene synthase, confirmed enhanced de novo chol...
Source: International Journal of Molecular Medicine - November 5, 2009 Category: Molecular Biology Authors: Nakamuta M, Yada R, Fujino T, Yada M, Higuchi N, Tanaka M, Miyazaki M, Kohjima M, Kato M, Yoshimoto T, Harada N, Taketomi A, Maehara Y, Koga M, Nishinakagawa T, Nakashima M, Kotoh K, Enjoji M Tags: Int J Mol Med Source Type: journals

Genetic and gene expression analyses of the polycystic ovary syndrome candidate gene fibrillin-3 and other fibrillin family members in human ovariesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several studies have demonstrated an association between polycystic ovary syndrome (PCOS) and the dinucleotide repeat microsatellite marker D19S884, which is located in intron 55 of the fibrillin-3 (FBN3) gene. Fibrillins, including FBN1 and 2, interact with latent transforming growth factor (TGF)-β-binding proteins (LTBP) and thereby control the bioactivity of TGFβs. TGFβs stimulate fibroblast replication and collagen production. The PCOS ovarian phenotype includes increased stromal collagen and expansion of the ovarian cortex, features feasibly influenced by abnormal fibrillin expression. To examine a poss...
Source: Molecular Human Reproduction - November 12, 2009 Category: Molecular Biology Authors: Prodoehl, M. J., Hatzirodos, N., Irving-Rodgers, H. F., Zhao, Z. Z., Painter, J. N., Hickey, T. E., Gibson, M. A., Rainey, W. E., Carr, B. R., Mason, H. D., Norman, R. J., Montgomery, G. W., Rodgers, R. J. Tags: Original Article Source Type: journals

Werner syndrome gene variants in human sarcomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Werner syndrome is an autosomal inherited disease that is characterized by premature aging. The gene mutated in Werner syndrome (WS), WRN, encodes both a 3[prime] [rarr] 5[prime] DNA helicase and a 3[prime] [rarr] 5[prime] DNA exonuclease. Among the WS phenotypes is an exceptionally high incidence of sarcomas. We asked whether spontaneous sarcomas, not known to be associated with WS, also harbor mutations or unreported single nucleotide polymorphisms (SNPs) in WRN. We analyzed RNA or DNA sequences within the helicase and exonuclease domains from 51 and 69 matched sarcoma and adjacent normal tissues, respectively. Among a t...
Source: Molecular Carcinogenesis - October 11, 2009 Category: Molecular Biology Authors: Jessica J. Hsu, Ashwini S. Kamath-Loeb, Eitan Glick, Brett Wallden, Karen Swisshelm, Brian P. Rubin, Lawrence A. Loeb Source Type: journals

TGFBR1*6A/9A polymorphism and cancer risk: a meta-analysis of 13,662 cases and 14,147 controls.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Published data on the association between TGFBR1*6A/9A polymorphism and cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 32 studies including 13,662 cases and 14,147 controls were involved in this meta-analysis. Overall, significantly elevated cancer risks were associated with TGFBR1*6A in all genetic models (for allelic effect: OR = 1.11; 95% CI = 1.03-1.21; for 6A/6A vs. 9A/9A: OR = 1.30; 95% CI = 1.01-1.69; for 9A/6A vs. 9A/9A: OR = 1.08; 95% CI = 1.01-1.15; for dominant model: OR = 1.08; 95% CI = 1.02-1.15; for recessive model: OR = 1.2...
Source: Molecular Biology Reports - November 1, 2009 Category: Molecular Biology Authors: Liao RY, Mao C, Qiu LX, Ding H, Chen Q, Pan HF Tags: Mol Biol Rep Source Type: journals

The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report we demonstrate for the first time that, when administered in combination, TGZ and ASA can produce a strong synergistic effect in growth inhibition and G1 arrest in lung cancer CL1-0 and A549 cells. Examination by colony formation assay revealed an even more profound synergy. In Western blot, combined TGZ and ASA also could downregulate Cdk2, E2F-1, cyclin B1, cyclin D3 protein, and the ratio of phospho-Rb/Rb. Importantly, apoptosis was synergistically induced by the combination treatment, as evidenced by caspase-3 activation and PARP cleavage. The involvement of PI3K/Akt inhibition and p27 upregulation, as w...
Source: Molecular Carcinogenesis - November 11, 2009 Category: Molecular Biology Authors: Kun-Huang Yan, Chih-Jung Yao, Hwan-You Chang, Gi-Ming Lai, Ann-Lii Cheng, Shuang-En Chuang Source Type: journals

Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract HTm4 (MS4A3) is a member of a family of four-transmembrane proteins designated MS4A. MS4A proteins fulfill diverse functions, acting as cell surface signaling molecules and intracellular adapter proteins. Early reports demonstrated that HTm4 is largely restricted to the hematopoietic lineage, and is involved in cell cycle control, via a regulatory interaction with the KAP phosphatase, Cyclin A and CDK2. Here we describe the expression pattern of HTm4 in peripheral blood cells using gene expression microarray technology, and in normal fetal and adult human tissues, as well as adult human cancers, using tissue m...
Source: J Cell Mol Med - October 9, 2009 Category: Molecular Biology Authors: Kutok JL, Yang X, Folkerth R, Adra CN Tags: J Cell Mol Med Source Type: journals

Translational advances and novel therapies for pancreatic ductal adenocarcinoma: hope or hype?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Review ArticlesSreenivasa Chandana, Daruka Mahadevan, Expert Reviews in Molecular Medicine, Volume 11 , pp e34AbstractBiological complexity, inaccessible anatomical location, nonspecific symptoms, lack of a screening biomarker, advanced disease at presentation and drug resistance epitomise pancreatic ductal adenocarcinoma (PDA) as a poor-prognosis, lethal disease. Twenty-five years of research (basic, translational and clinical) have barely made strides to improve survival, mainly because of a fundamental lack of knowledge of the biological processes initiating and propagating PDA. However, isolation of pancreas cancer ste...
Source: Expert Reviews in Molecular Medicine - November 18, 2009 Category: Molecular Biology Source Type: journals

Muscleblind-like 1 is a negative regulator of TGF-[beta]-dependent epithelial-mesenchymal transition of atrioventricular canal endocardial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The development of the valves and septa of the heart depends on the formation and remodeling of endocardial cushions. Here, we report that the alternative splicing regulator muscleblind-like 1 (MBNL1) exhibits a regionally restricted pattern of expression in canal region endocardium and ventricular myocardium during endocardial cushion development in chicken. Knockdown of MBNL1 in atrioventricular explants leads to a transforming growth factor [beta]-dependent increase in epithelial-mesenchymal transition (EMT) of endocardial cells. This reveals a novel role for MBNL1 during embryonic development, and represents the first ...
Source: Developmental Dynamics - November 4, 2009 Category: Molecular Biology Authors: Natalie A. Vajda, Kyle R. Brimacombe, Kathryn E. LeMasters, Andrea N. Ladd Source Type: journals

Trypanocidal drugs: mechanisms, resistance and new targetsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Review ArticlesShane R. Wilkinson, John M. Kelly, Expert Reviews in Molecular Medicine, Volume 11 , pp e31AbstractThe protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating infections that exert a considerable health burden on some of the poorest people on the planet. Treatment of trypanosome infections is dependent on a small number of drugs that have limited efficacy and can cause severe side effects. Here, we review the properties of these drugs and describe new findings on their modes of action and the mec...
Source: Expert Reviews in Molecular Medicine - October 30, 2009 Category: Molecular Biology Source Type: journals

Identification of hemagglutinin structural domain and polymorphisms which may modulate swine H1N1 interactions with human receptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results (i) contribute to better understanding of the origin of the novel A/H1N1 influenza virus, (ii) provide a tool for monitoring its molecular evolution (iii) predicts hotspots associated with enhanced infectivity in humans and (iv) identify therapeutic and diagnostic targets for prevention and treatment of A/H1N1 infection. (Source: BMC Structural Biology - Latest articles)
Source: BMC Structural Biology - Latest articles - September 27, 2009 Category: Molecular Biology Authors: Veljko VeljkovicHenry NimanSanja GlisicNevena VeljkovicVladimir PerovicClaude Muller Source Type: journals

Heterologous expression, purification and characterization of the influenza A virus M2e gene fused to Mycobacterium tuberculosis HSP70(359-610) in prokaryotic system as a fusion protein.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the concerns about influenza A vaccine based on M2e protein is their limited potency; hence, optimal approaches to enhance immunogenicity of M2e protein immunization remain to be established. It seems by linking this M2e-peptide to an appropriate carrier such as mycobacterium tuberculosis C-terminal 28-kDa domain of HSP70 (HSP70(359-610)), we can render it very immunogenic. According to previous reports, this study was designed to produce a novel influenza A virus recombinant fusion protein consisted of M2e, a potent immunogenic protein from influenza A virus, fused to C-terminal domain of mycobacterium tubercul...
Source: Molecular Biology Reports - October 7, 2009 Category: Molecular Biology Authors: Ebrahimi SM, Tebianian M Tags: Mol Biol Rep Source Type: journals

Expression and SNP association analysis of porcine FBXL4 gene.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As a kind of E3 ligase, the product of FBXL4 gene belongs to a member of FBLs which is the biggest eukaryotic subfamily of F-BOX proteins, it can recognize some substrate through particular protein-protein interaction domains. To investigate its functions, the polymorphism and association analysis was analyzed. The partial cDNA of porcine FBXL4 with 2384 bp long was first cloned; the deduced protein comprises a conserved F-BOX domain at position from the 277th to 332nd amino acid. The phylogenetic tree indicated porcine FBXL4 has the closest genetic relationship with bovine FBXL4 than other selected animal species. Ten...
Source: Molecular Biology Reports - September 18, 2009 Category: Molecular Biology Authors: Li Y, Yang SL, Tang ZL, Cui WT, Mu YL, Chu MX, Zhao SH, Wu ZF, Li K, Peng KM Tags: Mol Biol Rep Source Type: journals

Inhibition of nuclear factor kappa B transcription activity drives a synergistic effect of pyrrolidine dithiocarbamate and cisplatin for treatment of renal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined the synergistic effect of pyrrolidine dithiocarbamate (PDTC), a NF-κB inhibitor, and cisplatin, on two human metastatic RCC cell lines ACHN and SN12K1. Individual non-toxic concentrations of PDTC and cisplatin, when combined, synergistically induced a significant increase in apoptosis of the two RCC cell lines. In ACHN cells, the groups with nuclear translocation of NF-κB showed resistance to apoptosis, but in SN12K1 cells, the groups with NF-κB translocation were susceptible to apoptosis. The combination treatment significantly decreased the transcription activity of all NF-κB subunits i...
Source: Apoptosis - October 23, 2009 Category: Molecular Biology Tags: Apoptosis Source Type: journals

Metabolic profiling reveals key metabolic features of renal cell carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Recent evidence suggests that metabolic changes play a pivotal role in the biology of cancer and in particular renal cell carcinoma (RCC). Here, a global metabolite profiling approach was applied to characterize the metabolite pool of RCC and normal renal tissue. Advanced decision tree models were applied to characterize the metabolic signature of RCC and to explore features of metastasized tumors. The findings were validated in a second independent dataset. Vitamin E derivates and metabolites of glucose, fatty acid, and inositol phosphate metabolism determined the metabolic profile of RCC. Alpha-tocopherol, h...
Source: J Cell Mol Med - October 19, 2009 Category: Molecular Biology Authors: Catchpole G, Platzer A, Weikert C, Kempkensteffen C, Johannsen M, Krause H, Jung K, Miller K, Willmitzer L, Selbig J, Weikert S Tags: J Cell Mol Med Source Type: journals