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412699 records returned

The Authors Replyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - February 5, 2012 Category: Neurology Authors: Mazzone, LuigiVitiello, Benedetto Tags: Correspondence Source Type: research

The Need to Develop More Sensitive Tools to Accurately Detect Clinical Response to Treatment in ADHDemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - February 5, 2012 Category: Neurology Authors: Yang, RongwangMao, ShujiongLi, RongZhao, Zhengyan Tags: Correspondence Source Type: research

Aripiprazole: A Review of its Use in the Management of Schizophrenia in Adultsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - February 5, 2012 Category: Neurology Authors: Croxtall, Jamie D. Tags: Adis Drug Evaluation Source Type: research

The Role of Antipsychotics in the Management of Fibromyalgiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - February 5, 2012 Category: Neurology Authors: Calandre, Elena P.Rico-Villademoros, Fernando Tags: Review Articles Source Type: research

HIV-Associated Neurological Disorders: A Guide to Pharmacotherapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - February 5, 2012 Category: Neurology Authors: Tan, Ik L.McArthur, Justin C. Tags: Review Articles Source Type: research

Depression Following Traumatic Brain Injury: Epidemiology, Risk Factors and Managementemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - February 5, 2012 Category: Neurology Authors: Rapoport, Mark J. Tags: Therapy In Practice Source Type: research

Studies of Long-Term Use of Antidepressants: How Should the Data from Them be Interpreted?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - February 5, 2012 Category: Neurology Authors: El-Mallakh, Rif S.Briscoe, Brian Tags: Current Opinion Source Type: research

Upregulation of mucosal 5‐HT3 receptors is involved in restoration of colonic transit after pelvic nerve transectionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions & Inferences  Colonic motility was restored to approximately 70% normal over 1 week without further improvement at 2 weeks. Enteric nervous system compensated by upregulating mucosal 5‐HT3, but not 5‐HT4, receptors. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 5, 2012 Category: Gastroenterology Authors: I. Gribovskaja‐RuppT. TakahashiT. RidolfiL. KosinskiK. Ludwig Source Type: research

Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effectsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The aim of present study was to investigate the attenuating effects of Adenanthera pavonina L., Leguminosae-Mimosaceae seeds aqueous extract (APSAE), in streptozotocin (STZ)-induced diabetic neuropathy in rats. APSAE (50, 100 and 200 mg/kg per day) was given to diabetic rats for twelve weeks. Cold and hot water tail immersion tests, photoactometer and Rota-rod tests were performed to assess degree of colder, thermal, spontaneous motor activity and motor co-ordination changes respectively at different time intervals i.e., week 0, 4, 8 and 12. Tissue superoxide anion and total calcium levels were determined after twelve week...
Source: Revista Brasileira de Farmacognosia - February 5, 2012 Category: Drugs & Pharmacology Source Type: research

Sildenafil: Nonarteritic anterior ischaemic optic neuropathy: case reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 5, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Risperidone: Neuroleptic malignant syndrome in a child: case reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 5, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Peginterferon-: Optic neuropathy: case reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 5, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Metronidazole/tinidazole abuse: Encephalo-neuropathy: 2 case reportsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 5, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Buprenorphine/naloxone/neuropsychotherapeutics interaction: Obtundation: case reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 5, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Antipsychotics/valproic acid: Neuroleptic malignant syndrome: 2 case reportsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 5, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Clint Eastwood helps reveal secrets of brain evolutionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Brain scans of humans and monkeys while they watched a cowboy movie show that areas that are functionally similar aren't always in the same place (Source: New Scientist - Health)
Source: New Scientist - Health - February 5, 2012 Category: Consumer Health News Source Type: research

Clint Eastwood helps reveal secrets of brain evolutionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Brain scans of humans and monkeys while they watched a cowboy movie show that areas that are functionally similar aren't always in the same place (Source: New Scientist - The Human Brain)
Source: New Scientist - The Human Brain - February 5, 2012 Category: Neurology Source Type: research

Trigeminal Trophic Syndrome from Stroke: An Under-Recognized Central Neuropathic Itch Syndromeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: American Journal of Clinical Dermatology)
Source: American Journal of Clinical Dermatology - February 5, 2012 Category: Dermatology Authors: Curtis, Ashley R.Oaklander, Anne L.Johnson, AnnetteYosipovitch, Gil Tags: Case Reports Source Type: research

Scientists target cholesterol to treat brain tumorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Cancer)
Source: Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Carrie Printz Tags: CancerScope Source Type: research

Cedars-Sinai Neurology Researchers Present Findings At International Stroke Conferenceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Stroke experts from Cedars-Sinai Medical Center presented research updates at the International Stroke Conference of the American Heart Association/American Stroke Association Feb. 1 through Feb. 3 in New Orleans. Highlights included: Thrombin Activity Associated with Neuronal Damage during Acute Stage of Ischemic Stroke After ischemic stroke - the type caused by a clogged artery but with no bleeding into the brain - a normal protein that plays a positive role in blood clotting escapes intact arteries and seriously damages healthy brain cells... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2012 Category: Consumer Health News Tags: Stroke Source Type: news

Mental Illness Suspect Genes Found To Be Among The Most Environmentally Responsive By NIH Studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
For the first time, scientists have tracked the activity, across the lifespan, of an environmentally responsive regulatory mechanism that turns genes on and off in the brain's executive hub. Among key findings of the study by National Institutes of Health scientists: genes implicated in schizophrenia and autism turn out to be members of a select club of genes in which regulatory activity peaks during an environmentally-sensitive critical period in development... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2012 Category: Consumer Health News Tags: Schizophrenia Source Type: news

A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical samples. We have developed a high throughput, statistically robust technique that quantitates autophagy in primary human leukocytes using the Image stream, an imaging flow cytometer. We validate this method on cell lines and primary cells knocked down for essential autophagy genes. Also, using this method we sho...
Source: Autophagy - February 5, 2012 Category: Cytology Authors: Phadwal K, Alegre-Abarrategui J, Watson AS, Pike L, Anbalagan S, Hammond EM, Wade-Martins R, McMichael A, Klenerman P, Simon AK Tags: Autophagy Source Type: research

Increased medial orbitofrontal [18F]fluorodopa uptake in Parkinsonian impulse control disordersemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions:Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine‐replacement therapy in PD. © 2012 Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - February 5, 2012 Category: Neurology Authors: Juho JoutsaKirsti MartikainenSolja NiemeläJarkko JohanssonSarita ForsbackJuha O. RinneValtteri Kaasinen Tags: Brief Report Source Type: research

Why Human Brains Are Smarter Than Chimp Brainsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Synapses in key brain region continues to develop much longer in babies than in primates, study finds (Source: The Doctors Lounge - Neurology)
Source: The Doctors Lounge - Neurology - February 5, 2012 Category: Neurology Authors: webmaster at doctorslounge.com Tags: Neurology, Pediatrics, Research, News, Source Type: news

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogeneemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma. (Source: BioMed Central)
Source: BioMed Central - February 5, 2012 Category: Journals (General) Authors: Maria MeehanLaavanya ParthasarathiNiamh MoranCaroline A JefferiesNiamh FoleyElisa LazzariDerek MurphyJacqueline RyanBerenice OrtizArmida W M FabiusTimothy A ChanRaymond L Stallings Source Type: research

Minorities with Afib at Greater Risk for Brain Bleeds (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(MedPage Today) -- NEW ORLEANS — Among patients with atrial fibrillation, being Asian or black were among the risk factors associated with intracranial hemorrhage, researchers found. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - February 4, 2012 Category: Consumer Health News Source Type: news

W5: Life or death - who gets to decide?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Hassan Rasouli, an electrical engineer, brought his family to Toronto from Iran, in the spring of 2010. Five months later, what was supposed to be routine surgery for a benign brain tumor, left Hassan unconscious. Bacterial meningitis had infected his brain. (Source: CTV Health)
Source: CTV Health - February 4, 2012 Category: Consumer Health News Source Type: news

Does A Lab-Measured Compassionate Brain Fare Well In Real Life?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A new series of studies is being launched by the University of Wisconsin-Madison, exploring insight knowledge on how laboratory measures of moral qualities, such as compassion, relate to real-life behavior. Founder of the UW's Center for Investigating Healthy Minds (CIHM), Dr. Richard J. Davidson at the Waisman Center, was awarded a three-year, $1.7 million grant from the John Templeton Foundation for developing laboratory and real life measures of moral qualities, such as compassion and selflessness... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2012 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Memory Function - Decaffeinated Coffee May Helpemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Drinking decaffeinated coffee may improve brain energy metabolism associated with diabetes type 2, according to a study published in Nutritional Neuroscience and carried out by researchers at Mount Sinai School of Medicine. Brain energy metabolism is a dysfunction with a known risk factor for dementia and other neurodegenerative disorders like Alzheimer's disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2012 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Treating Brain Injuries With Stem Cell Transplants - Promising Resultsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The February edition of Neurosurgery reports that animal experiments in brain-injured rats have shown that stem cells injected via the carotid artery travel directly to the brain, greatly enhancing functional recovery... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2012 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Increased [3H]D‐aspartate release and changes in glutamate receptor expression in the hippocampus of the mnd mouseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractNeuronal ceroid lipofuscinoses (NCLs) are a group of hereditary childhood diseases characterized mainly by lipopigment accumulation and a multisystemic pattern of symptoms including mental retardation, seizures, motor impairment, and blindness. The mnd mouse, carrying a mutation in the Cln8 gene, has been proposed as a model of epilepsy with mental retardation (EPMR, ornorthern epilepsy). We recently showed neuronal hyperexcitability and seizure hypersusceptibility in mnd mice. To elucidate the cellular mechanisms related to hippocampal hyperexcitability, the glutamatergic transmission and the expression of postsyn...
Source: Journal of Neuroscience Research - February 4, 2012 Category: Neuroscience Authors: Paolo BiginiMarco MilaneseFabrizio GardoniAnnalisa LonghiTiziana BonifacinoSara BarberaElena FumagalliMonica Di LucaTiziana MenniniGiambattista Bonanno Tags: Research Article Source Type: research

Study Looks At Reasons For Lack Of Improvement In Outcomes For Treatment Of Unruptured Brain Aneurysmsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Despite advances in the diagnosis and treatment of unruptured brain aneurysms, outcomes have remained stagnant over the last 10 years. This can be explained by the dramatic proliferation of minimally invasive endoscopic coiling procedures at lower-volume community hospitals, where outcomes are inferior. These findings are reported in a study by neurologists, neurosurgeons and neuro-anesthesiologists at NewYork-Presbyterian Hospital/Columbia University Medical Center and published in the journal Stroke... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2012 Category: Consumer Health News Tags: Stroke Source Type: news

Brain Blood Flow And Oxygen Monitored By First-Of-Its-Kind Head Patchemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A research team led by investigators at Mayo Clinic in Florida has found that a small device worn on a patient's brow can be useful in monitoring stroke patients in the hospital. The device measures blood oxygen, similar to a pulse oximeter, which is clipped onto a finger. Their study, published in Neurosurgical Focus, suggests this tool, known as frontal near-infrared spectroscopy (NIRS), could offer hospital physicians a safe and cost-effective way to monitor patients who are being treated for a stroke, in real time... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2012 Category: Consumer Health News Tags: Stroke Source Type: news

[Articles] Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic reviewemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Intrauterine and neonatal insults have a high risk of causing substantial long-term neurological morbidity. Comparable cohort studies in resource-poor regions should be done to properly assess the burden of these conditions, and long-term outcomes, such as chronic disease, and to inform policy and programme investments. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Michael K Mwaniki, Maurine Atieno, Joy E Lawn, Charles RJC Newton Tags: Articles Source Type: research

[Comment] Behavioural problems from perinatal and neonatal insultsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The nature, scale, and interactions of behavioural disorders after neonatal and perinatal insults, including preterm birth and infectious diseases, are not well understood. In The Lancet, Michael Mwaniki and colleagues present a broad systematic review of the type and probability of development of a range of neurodevelopmental sequelae, in which they have included 153 research studies and 22 161 liveborn children. The authors report a very high overall prevalence of at least one deficit in any domain (median risk 39·4%, IQR 20·0–54·8%). (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Lucy C Thompson, Christopher Gillberg Tags: Comment Source Type: research

Aspirin, Warfarin Fare Equally for Heart Failure Patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Each of these anti-clotting drugs had similar effectiveness in preventing deaths, study found (Source: The Doctors Lounge - Cardiology)
Source: The Doctors Lounge - Cardiology - February 4, 2012 Category: Cardiology Authors: webmaster at doctorslounge.com Tags: Cardiology, Family Medicine, Hematology, Neurology, Nursing, Pharmacy, News, Source Type: news

What Are the Causes of Bipolar Disorder?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In Part 2 of Bipolar for Beginners, we take a look at what scientists believe are the causes - genetic, physical and psychological - of bipolar disorder. For whatever reason you want to know more about this illness, here is information in clear English that will answer some of your questions about things like whether bipolar is inherited, the part brain chemistry plays in bipolar, and how researchers believe it all fits together. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - February 4, 2012 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Complete electrode model in EEG: relationship and differences to the point electrode model.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract In electroencephalography (EEG) source analysis, a primary current density generated by the neural activity of the brain is reconstructed from external electrode voltage measurements. This paper focuses on accurate and effective simulations of EEG through the complete electrode model (CEM). The CEM allows for the incorporation of the electrode size, shape and effective contact impedance into the forward simulation. Both neural currents in the brain and shunting currents between the electrodes and the skin can affect the measured voltages in the CEM. The goal of this study was to investigate the CEM by comp...
Source: Physics in Medicine and Biology - February 3, 2012 Category: Physics Authors: Pursiainen S, Lucka F, Wolters CH Tags: Phys Med Biol Source Type: research

Cerebral Microdialysis Effects of Propofol versus Midazolam in Severe Traumatic Brain Injuryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Journal of Neurotrauma , Vol. 0, No. 0. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - February 3, 2012 Category: Neurology Tags: article Source Type: research

'Cycling gave me my freedom back'email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
'How cycling helped me fight my brain tumours' (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 3, 2012 Category: Consumer Health News Source Type: news

Aging-Caloric Restriction and BDNF-Leptinemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study, the investigators found that by restricting calories in rats, DVC BDNF immunoreactive concentrations were elevated and resulting in satiety threshold stability.  This indicates functional desensitization of the DVC to these signals: Karine Bédard, Stéphanie Segura, Stéphanie Mahaut, Catherine Tardivel, Guylaine Ferland, Bruno Lebrun, Pierrette Gaudreau. Effects of aging and caloric restriction on brainstem satiety center signals in rats. Mechanisms of Ageing and Development. dx.doi.org/10.1016/j.mad.2012.01.004.The authors used our BDNF Antibody to determine expression in the DVC.....goat s...
Source: Neuromics - February 3, 2012 Category: Neuroscience Tags: Cytokine signaling BDNF antibody Brian Derived Neurotrophic Factors Autonomic nervous system Neurotrophins Leptin antibody Dorsal vagal complex Source Type: news

Hippocampal Drebrin Loss in Mild Cognitive Impairmentemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Neurodegenerative Dis (DOI:10.1159/000333122) (Source: Karger Publishers)
Source: Karger Publishers - February 3, 2012 Category: Cancer & Oncology Source Type: research

Heart Failure Linked to Loss of Brain Gray Matter Heart Failure Linked to Loss of Brain Gray Matteremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Heart failure is associated with a decline in mental function and loss of gray matter in the brain, which may make it more difficult for patients to follow instructions regarding their medication, a new Australian study has found. Heartwire (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Cardiology News Source Type: news

Heart failure linked to loss of brain gray matteremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Heart failure is associated with a decline in mental function and loss of gray matter in the brain, which may make it more difficult for patients to follow instructions regarding their medication, a new Australian study has found. (Source: theHeart.org)
Source: theHeart.org - February 3, 2012 Category: Cardiology Source Type: news

Aspirin as Effective as Warfarin in Heart Failure: WARCEFAspirin as Effective as Warfarin in Heart Failure: WARCEFemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Although there was an edge for warfarin for those treated for 4 or more years, there is "no compelling" reason to anticoagulate these patients, researchers say. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

No Stroke Prevention Benefit of Clopidogrel Plus AspirinNo Stroke Prevention Benefit of Clopidogrel Plus Aspirinemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A new study shows that the combination clopidogrel and aspirin increases risk of hemorrhage and mortality including non-vascular mortality vs aspirin alone. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Synthesis and anticonvulsant activity of 1‐(2‐(8‐(benzyloxy)quinolin‐2‐yl)‐1‐butyrylcyclopropyl)‐3‐substituted urea derivativesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In the present study on the development of new anticonvulsants, sixteen new1‐(2‐(8‐(benzyloxy)quinolin‐2‐yl)‐1‐butyrylcyclopropyl)‐3‐substituted urea derivatives were synthesized and tested for anticonvulsant activity using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) screens, which are the most widely employed seizure models for early identification of candidate anticonvulsants. Their neurotoxicity were determined applying the rotorod test. Three compounds 7a, 7e and 7m showed promising anticonvulsant activities in both models employed for anticonvulsant evaluation. The most ac...
Source: Chemical Biology and Drug Design - February 3, 2012 Category: Biology Authors: Xianran HeMin ZhongJin YangZhongyuan WuYuling XiaoHao GuoXianming Hu Source Type: research

Gene regulator in brain's executive hub tracked across lifespan -- NIH studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
For the first time, scientists have tracked the activity, across the lifespan, of an environmentally responsive regulatory mechanism that turns genes on and off in the brain's executive hub. Among key findings of the study by National Institutes of Health scientists: genes implicated in schizophrenia and autism turn out to be members of a select club of genes in which regulatory activity peaks during an environmentally-sensitive critical period in development. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - February 3, 2012 Category: American Health Source Type: news

Heparan sulfate sulfatase SULF2 regulates PDGFR{alpha} signaling and growth in human and mouse malignant gliomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study, we demonstrated that the extracellular sulfatase, SULF2, an enzyme that regulates multiple HSPG-dependent RTK signaling pathways, was expressed in primary human GBM tumors and cell lines. Knockdown of SULF2 in human GBM cell lines and generation of gliomas from Sulf2–/– tumorigenic neurospheres resulted in decreased growth in vivo in mice. We found a striking SULF2 dependence in activity of PDGFRα, a major signaling pathway in GBM. Ablation of SULF2 resulted in decreased PDGFRα phosphorylation and decreased downstream MAPK signaling activity. Interestingly, in a survey of SULF...
Source: Journal of Clinical Investigation - February 3, 2012 Category: Biomedical Science Authors: Joanna J. Phillips, Emmanuelle Huillard, Aaron E. Robinson, Anna Ward, David H. Lum, Mei-Yin Polley, Steven D. Rosen, David H. Rowitch, Zena Werb Source Type: research

As If You Needed Another Reason to Quitemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nicotine changes the way genes are expressed, which may prime the brain for addiction.read more (Source: Psychology Today Addiction Center)
Source: Psychology Today Addiction Center - February 3, 2012 Category: Addiction Authors: Kayt Sukel Tags: Addiction Animal Behavior Eating Disorders Memory Neuroscience Stress cocaine addiction columbia university conjecture diseases and disorders epigenetic changes gateway drug genes home message landmark study molecular mechani Source Type: news