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This page shows you the most recent publications within this specialty of the MedWorm directory.

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OROS Hydromorphone Prolonged Release: A Review of its Use in the Management of Chronic, Moderate to Severe PainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - March 20, 2010 Category: Neurology Authors: Carter, Natalie J.Keating, Gillian M. Tags: Adis Drug Evaluation Source Type: journals

Pramipexole Extended Release: In Parkinsons DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - March 20, 2010 Category: Neurology Authors: Chwieduk, Claudine M.Curran, Monique P. Tags: Adis Drug Profile Source Type: journals

For What Diagnoses Are Psychotropic Medications Being Prescribed?: A Nationally Representative Survey of PhysiciansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - March 20, 2010 Category: Neurology Authors: Mark, Tami L. Tags: Original Research Articles Source Type: journals

Cholinesterase Inhibitors as Adjunctive Therapy in Patients with Schizophrenia and Schizoaffective Disorder: A Review and Meta-Analysis of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - March 20, 2010 Category: Neurology Authors: Ribeiz, Salma R.I.Bassitt, Debora P.Arrais, Jony A.Avila, RenataSteffens, David C.Bottino, Cassio M.C. Tags: Original Research Articles Source Type: journals

Childhood Medulloblastoma: Current Status of Biology and TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - March 20, 2010 Category: Neurology Authors: Klesse, Laura J.Bowers, Daniel C. Tags: Review Articles Source Type: journals

Thalamic label patterns suggest primary and ventral auditory fields are distinct core regionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A hierarchical scheme proposed by Kaas and colleagues suggests that primate auditory cortex can be divided into core and belt regions based on anatomic connections with thalamus and distinctions among response properties. According to their model, core auditory cortex receives predominantly unimodal sensory input from the ventral nucleus of the medial geniculate body (MGBv); whereas belt cortex receives predominantly cross-modal sensory input from nuclei outside the MGBv. We previously characterized distinct response properties in rat primary (A1) versus ventral auditory field (VAF) cortex; however, it has been unclear whe...
Source: The Journal of Comparative Neurology - March 20, 2010 Category: Neurology Authors: Douglas A. Storace, Nathan C. Higgins, Heather L. Read Tags: Cover Image Source Type: journals

Stemedica Files IND Application With FDA For Treatment Of Stroke With Adult Allogeneic Mesenchymal Stem CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stemedica Cell Technologies, Inc. (Stemedica), a world leader in stem cell research and manufacturing, announced that it has filed an Investigative New Drug (IND) application with the U.S. Food and Drug Administration (FDA) for a clinical trial... (Source: Stroke / Neuroprotection News From Medical News Today)
Source: Stroke / Neuroprotection News From Medical News Today - March 20, 2010 Category: Neurology Tags: Stroke Source Type: news

Patients Recently Suffering Non-Severe Strokes May Be Eligible For Clinical Trial Of Minimally Invasive Stenting Procedure To Open Brain ArteriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Individuals between 30 and 80 years of age, who have had a transient ischemic attack (TIA) or non-severe stroke within the past 30 days, and who cannot be treated surgically, may be eligible to participate in a Phase III clinical trial of a minimally invasive stenting procedure at the Cedars-Sinai Neurovascular Center... (Source: Stroke / Neuroprotection News From Medical News Today)
Source: Stroke / Neuroprotection News From Medical News Today - March 20, 2010 Category: Neurology Tags: Stroke Source Type: news

Cellular structure of the human cerebral cortexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Brain)
Source: Brain - March 20, 2010 Category: Neurology Authors: Jones, E. G. Tags: Book Review Source Type: journals

Cerebellar agenesis revisitedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New clinical and employment information, together with over-looked previously published information, on a patient (H.C.) is reviewed. H.C., who died at the age of 76 in 1939, was found, by chance during anatomical dissection, to lack a cerebellum. This synthesis challenges an unusual and interesting account of cerebellar agenesis published in Brain in 1994 by Glickstein (see also Glickstein, 2006), in which the allegedly ‘bogus’ oral history of this individual's motor skills was held to have led to ‘medical myth making’. Part of the burden of the 1994 paper was to show that ‘cerebellar agenesi...
Source: Brain - March 20, 2010 Category: Neurology Authors: Boyd, C.A.R Tags: Occasional Paper Source Type: journals

Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The inferior olivary nuclei clearly play a role in creating oculopalatal tremor, but the exact mechanism is unknown. Oculopalatal tremor develops some time after a lesion in the brain that interrupts inhibition of the inferior olive by the deep cerebellar nuclei. Over time the inferior olive gradually becomes hypertrophic and its neurons enlarge developing abnormal soma-somatic gap junctions. However, results from several experimental studies have confounded the issue because they seem inconsistent with a role for the inferior olive in oculopalatal tremor, or because they ascribe the tremor to other brain areas. Here we lo...
Source: Brain - March 20, 2010 Category: Neurology Authors: Shaikh, A. G., Hong, S., Liao, K., Tian, J., Solomon, D., Zee, D. S., Leigh, R. J., Optican, L. M. Tags: Original Articles Source Type: journals

Limb-shaking transient ischaemic attacks in patients with internal carotid artery occlusion: a case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, limb-shaking transient ischaemic attacks in patients with internal carotid artery occlusion can be recognized by their short duration, are often accompanied by paresis and precipitated by rising or exercise and are indicative of an impaired haemodynamic state of the brain. (Source: Brain)
Source: Brain - March 20, 2010 Category: Neurology Authors: Persoon, S., Kappelle, L. J., Klijn, C. J. M. Tags: Original Articles Source Type: journals

Neuroimaging of eye position reveals spatial neglectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conjugate eye deviation describes the tonic horizontal deviation of the eyes in acute stroke patients. Here we investigate whether measuring patients’ eye-in-head position in clinical magnetic resonance imaging or computed tomography scans obtained at admission shows a specific relationship to spatial neglect. We investigated 124 continuously admitted subjects with unilateral, first-ever left- or right-sided stroke. To control for the possibility that the degree of eye deviation is related to lesion size rather than spatial neglect, overall lesion volume was used as a covariate in the statistical analysis. Horizontal...
Source: Brain - March 20, 2010 Category: Neurology Authors: Becker, E., Karnath, H.-O. Tags: Original Articles Source Type: journals

Effect of prism adaptation on left dichotic listening deficit in neglect patients: glasses to hear better?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unilateral neglect is a disabling syndrome frequently observed following right hemisphere brain damage. Symptoms range from visuo-motor impairments through to deficient visuo-spatial imagery, but impairment can also affect the auditory modality. A short period of adaptation to a rightward prismatic shift of the visual field is known to improve a wide range of hemispatial neglect symptoms, including visuo-manual tasks, mental imagery, postural imbalance, visuo-verbal measures and number bisection. The aim of the present study was to assess whether the beneficial effects of prism adaptation may generalize to auditory manifes...
Source: Brain - March 20, 2010 Category: Neurology Authors: Jacquin-Courtois, S., Rode, G., Pavani, F., O'Shea, J., Giard, M. H., Boisson, D., Rossetti, Y. Tags: Original Articles Source Type: journals

Neuroanatomy of hemispatial neglect and its functional components: a study using voxel-based lesion-symptom mappingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Spatial neglect is a perplexing neuropsychological syndrome, in which patients fail to detect (and/or respond to) stimuli located contralaterally to their (most often right) hemispheric lesion. Neglect is characterized by a wide heterogeneity, and a role for multiple components has been suggested, but the exact nature of the critical components remains unclear. Moreover, many different lesion sites have been reported, leading to enduring controversies about the relative contribution of different cortical and/or subcortical brain regions. Here we report a systematic anatomo-functional study of 80 patients with a focal right...
Source: Brain - March 20, 2010 Category: Neurology Authors: Verdon, V., Schwartz, S., Lovblad, K.-O., Hauert, C.-A., Vuilleumier, P. Tags: Original Articles Source Type: journals

Deviant processing of letters and speech sounds as proximate cause of reading failure: a functional magnetic resonance imaging study of dyslexic childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Learning to associate auditory information of speech sounds with visual information of letters is a first and critical step for becoming a skilled reader in alphabetic languages. Nevertheless, it remains largely unknown which brain areas subserve the learning and automation of such associations. Here, we employ functional magnetic resonance imaging to study letter–speech sound integration in children with and without developmental dyslexia. The results demonstrate that dyslexic children show reduced neural integration of letters and speech sounds in the planum temporale/Heschl sulcus and the superior temporal sulcus....
Source: Brain - March 20, 2010 Category: Neurology Authors: Blau, V., Reithler, J., van Atteveldt, N., Seitz, J., Gerretsen, P., Goebel, R., Blomert, L. Tags: Original Articles Source Type: journals

High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we used T2-weighted magnetic resonance imaging at 9.4 T to detect grey matter lesions in fixed post-mortem multiple sclerosis motor cortex. Furthermore, we produced T1, T2 and magnetization transfer ratio maps, and correlated these indices with quantitative histology [neuronal density, intensity of immunostaining for myelin basic protein (reflecting myelin content) and phosphorylated neurofilament (reflecting axonal area)] using t-tests and multivariate regression. In 21 tissue samples, 28 cortical grey matter lesions were visible on both T2-weighted magnetic resonance imaging and sections immunostained for ...
Source: Brain - March 20, 2010 Category: Neurology Authors: Schmierer, K., Parkes, H. G., So, P.-W., An, S. F., Brandner, S., Ordidge, R. J., Yousry, T. A., Miller, D. H. Tags: Original Articles Source Type: journals

Brain tissue sodium concentration in multiple sclerosis: a sodium imaging study at 3 teslaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study shows the feasibility of using in vivo sodium magnetic resonance imaging at 3 T in patients with multiple sclerosis. Our findings suggest that the abnormal values of the tissue sodium concentration in patients with relapsing–remitting multiple sclerosis might reflect changes in cellular composition of the lesions and/or changes in cellular and metabolic integrity. Sodium magnetic resonance imaging has the potential to provide insight into the pathophysiological mechanisms of tissue injury when correlation with histopathology becomes available. (Source: Brain)
Source: Brain - March 20, 2010 Category: Neurology Authors: Inglese, M., Madelin, G., Oesingmann, N., Babb, J. S., Wu, W., Stoeckel, B., Herbert, J., Johnson, G. Tags: Original Articles Source Type: journals

Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Astrocytes are prominent participants in the response of the central nervous system to injury, including neuroinflammatory insults. Rodent astrocytes in vitro have been shown to express voltage-gated sodium channels in a dynamic manner, with a switch in expression of tetrodotoxin-sensitive to tetrodotoxin-resistant channels in reactive astrocytes. However, the expression of sodium channels in human astrocytes has not been studied, and it is not known whether there are changes in the expression of sodium channels in reactive astrocytes of the human central nervous system. Here, we demonstrate a focal and robust upregulation...
Source: Brain - March 20, 2010 Category: Neurology Authors: Black, J. A., Newcombe, J., Waxman, S. G. Tags: Original Articles Source Type: journals

Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oligodendrocyte loss and demyelination are major pathological hallmarks of multiple sclerosis. In pattern III lesions, inflammation is minor in the early stages, and oligodendrocyte apoptosis prevails, which appears to be mediated at least in part through mitochondrial injury. Here, we demonstrate poly(ADP-ribose) polymerase activation and apoptosis inducing factor nuclear translocation within apoptotic oligodendrocytes in such multiple sclerosis lesions. The same morphological and molecular pathology was observed in an experimental model of primary demyelination, induced by the mitochondrial toxin cuprizone. Inhibition of...
Source: Brain - March 20, 2010 Category: Neurology Authors: Veto, S., Acs, P., Bauer, J., Lassmann, H., Berente, Z., Setalo, G., Borgulya, G., Sumegi, B., Komoly, S., Gallyas, F., Illes, Z. Tags: Original Articles Source Type: journals

Reactive microgliosis: extracellular {micro}-calpain and microglia-mediated dopaminergic neurotoxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microglia, the innate immune cells in the brain, can become chronically activated in response to dopaminergic neuron death, fuelling a self-renewing cycle of microglial activation followed by further neuron damage (reactive microgliosis), which is implicated in the progressive nature of Parkinson’s disease. Here, we use an in vitro approach to separate neuron injury factors from the cellular actors of reactive microgliosis and discover molecular signals responsible for chronic and toxic microglial activation. Upon injury with the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium, N27 cells (dopaminergic neuron cell...
Source: Brain - March 20, 2010 Category: Neurology Authors: Levesque, S., Wilson, B., Gregoria, V., Thorpe, L. B., Dallas, S., Polikov, V. S., Hong, J.-S., Block, M. L. Tags: Original Articles Source Type: journals

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mutations of mitochondrial DNA are associated with a wide spectrum of disorders, primarily affecting the central nervous system and muscle function. The specific consequences of mitochondrial DNA mutations for neuronal pathophysiology are not understood. In order to explore the impact of mitochondrial mutations on neuronal biochemistry and physiology, we have used fluorescence imaging techniques to examine changes in mitochondrial function in neurons differentiated from mouse embryonic stem-cell cybrids containing mitochondrial DNA polymorphic variants or mutations. Surprisingly, in neurons carrying a severe mutation in re...
Source: Brain - March 20, 2010 Category: Neurology Authors: Abramov, A. Y., Smulders-Srinivasan, T. K., Kirby, D. M., Acin-Perez, R., Enriquez, J. A., Lightowlers, R. N., Duchen, M. R., Turnbull, D. M. Tags: Original Articles Source Type: journals

Mitochondrial DNA mutations affect calcium handling in differentiated neuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mutations in the mitochondrial genome are associated with a wide range of neurological symptoms, but many aspects of the basic neuronal pathology are not understood. One candidate mechanism, given the well-established role of mitochondria in calcium buffering, is a deficit in neuronal calcium homoeostasis. We therefore examined calcium responses in the neurons derived from various ‘cybrid’ embryonic stem cell lines carrying different mitochondrial DNA mutations. Brief (~50 ms), focal glutamatergic stimuli induced a transient rise in intracellular calcium concentration, which was visualized by bulk loading the c...
Source: Brain - March 20, 2010 Category: Neurology Authors: Trevelyan, A. J., Kirby, D. M., Smulders-Srinivasan, T. K., Nooteboom, M., Acin-Perez, R., Enriquez, J. A., Whittington, M. A., Lightowlers, R. N., Turnbull, D. M. Tags: Original Articles Source Type: journals

Multi-system neurological disease is common in patients with OPA1 mutationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Additional neurological features have recently been described in seven families transmitting pathogenic mutations in OPA1, the most common cause of autosomal dominant optic atrophy. However, the frequency of these syndromal ‘dominant optic atrophy plus’ variants and the extent of neurological involvement have not been established. In this large multi-centre study of 104 patients from 45 independent families, including 60 new cases, we show that extra-ocular neurological complications are common in OPA1 disease, and affect up to 20% of all mutational carriers. Bilateral sensorineural deafness beginning in late c...
Source: Brain - March 20, 2010 Category: Neurology Authors: Yu-Wai-Man, P., Griffiths, P.G., Gorman, G.S., Lourenco, C.M., Wright, A.F., Auer-Grumbach, M., Toscano, A., Musumeci, O., Valentino, M.L., Caporali, L., Lamperti, C., Tallaksen, C.M., Duffey, P., Miller, J., Whittaker, R.G., Baker, M.R., Jackson, M.J., C Tags: Original Articles Source Type: journals

Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to assess thermal and mechanical perception and pain thresholds in primary idiopathic restless legs syndrome and secondary restless legs syndrome associated with small fibre neuropathy. Twenty-one patients (age: 53.4 ± 8.4, n = 3, male) with primary restless legs syndrome and 13 patients (age: 63.0 ± 8.2, n = 1, male) with secondary restless legs syndrome associated with small fibre neuropathy were compared with 20 healthy subjects (age: 58.0 ± 7.0; n = 2, male). Differential diagnosis of secondary restless legs syndrome associated with small fibre neuropathy was based on clinical symp...
Source: Brain - March 20, 2010 Category: Neurology Authors: Bachmann, C. G., Rolke, R., Scheidt, U., Stadelmann, C., Sommer, M., Pavlakovic, G., Happe, S., Treede, R.-D., Paulus, W. Tags: Original Articles Source Type: journals

Reversing cognitive-motor impairments in Parkinson's disease patients using a computational modelling approach to deep brain stimulation programmingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deep brain stimulation in the subthalamic nucleus is an effective and safe surgical procedure that has been shown to reduce the motor dysfunction of patients with advanced Parkinson’s disease. Bilateral subthalamic nucleus deep brain stimulation, however, has been associated with declines in cognitive and cognitive–motor functioning. It has been hypothesized that spread of current to nonmotor areas of the subthalamic nucleus may be responsible for declines in cognitive and cognitive–motor functioning. The aim of this study was to assess the cognitive–motor performance in advanced Parkinson’s d...
Source: Brain - March 20, 2010 Category: Neurology Authors: Frankemolle, A. M. M., Wu, J., Noecker, A. M., Voelcker-Rehage, C., Ho, J. C., Vitek, J. L., McIntyre, C. C., Alberts, J. L. Tags: Original Articles Source Type: journals

Dopaminergic modulation of striato-frontal connectivity during motor timing in Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with Parkinson’s disease experience motor and perceptual timing difficulties, which are ameliorated by dopaminergic medication. We investigated the neural correlates of motor timing in Parkinson’s disease, including the effects of dopaminergic medication on patterns of brain activation. Eight patients with Parkinson’s disease and eight healthy controls were scanned with H152 positron emission tomography while engaged in three tasks: synchronization (right index finger tapping in synchrony with a tone presented at 1 Hz), continuation (tapping at 1 Hz in the absence of a tone), and a control simple...
Source: Brain - March 20, 2010 Category: Neurology Authors: Jahanshahi, M., Jones, C. R. G., Zijlmans, J., Katzenschlager, R., Lee, L., Quinn, N., Frith, C. D., Lees, A. J. Tags: Original Articles Source Type: journals

DJ-1 and {alpha}-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the nature of DJ-1 and -synuclein in human cerebrospinal fluid was studied by a combination of western blotting, gel filtration and mass spectrometry. Sensitive and quantitative Luminex assays detecting most, if not all, species of DJ-1 and -synuclein in human cerebrospinal fluid were established. Cerebrospinal fluid concentrations of DJ-1 and -synuclein from 117 patients with Parkinson’s disease, 132 healthy individuals and 50 patients with Alzheimer’s disease were analysed using newly developed, highly sensitive Luminex technology while controlling for several major confounders. A total of 299 ...
Source: Brain - March 20, 2010 Category: Neurology Authors: Hong, Z., Shi, M., Chung, K. A., Quinn, J. F., Peskind, E. R., Galasko, D., Jankovic, J., Zabetian, C. P., Leverenz, J. B., Baird, G., Montine, T. J., Hancock, A. M., Hwang, H., Pan, C., Bradner, J., Kang, U. J., Jensen, P. H., Zhang, J. Tags: Original Articles Source Type: journals

Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurodegeneration with brain iron accumulation encompasses a heterogeneous group of rare neurodegenerative disorders that are characterized by iron accumulation in the brain. Severe generalized dystonia is frequently a prominent symptom and can be very disabling, causing gait impairment, difficulty with speech and swallowing, pain and respiratory distress. Several case reports and one case series have been published concerning therapeutic outcome of pallidal deep brain stimulation in dystonia caused by neurodegeneration with brain iron degeneration, reporting mostly favourable outcomes. However, with case studies, there ma...
Source: Brain - March 20, 2010 Category: Neurology Authors: Timmermann, L., Pauls, K. A. M., Wieland, K., Jech, R., Kurlemann, G., Sharma, N., Gill, S. S., Haenggeli, C. A., Hayflick, S. J., Hogarth, P., Leenders, K. L., Limousin, P., Malanga, C. J., Moro, E., Ostrem, J. L., Revilla, F. J., Santens, P., Schnitzler Tags: Original Articles Source Type: journals

Increased sensorimotor network activity in DYT1 dystonia: a functional imaging studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurophysiological studies have provided evidence of primary motor cortex hyperexcitability in primary dystonia, but several functional imaging studies suggest otherwise. To address this issue, we measured sensorimotor activation at both the regional and network levels in carriers of the DYT1 dystonia mutation and in control subjects. We used 15Oxygen-labelled water and positron emission tomography to scan nine manifesting DYT1 carriers, 10 non-manifesting DYT1 carriers and 12 age-matched controls while they performed a kinematically controlled motor task; they were also scanned in a non-motor audio-visual control conditio...
Source: Brain - March 20, 2010 Category: Neurology Authors: Carbon, M., Argyelan, M., Habeck, C., Ghilardi, M. F., Fitzpatrick, T., Dhawan, V., Pourfar, M., Bressman, S. B., Eidelberg, D. Tags: Original Articles Source Type: journals

Attenuated variants of Lesch-Nyhan diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lesch–Nyhan disease is a neurogenetic disorder caused by deficiency of the enzyme hypoxanthine–guanine phosphoribosyltransferase. The classic form of the disease is described by a characteristic syndrome that includes overproduction of uric acid, severe generalized dystonia, cognitive disability and self-injurious behaviour. In addition to the classic disease, variant forms of the disease occur wherein some clinical features are absent or unusually mild. The current studies provide the results of a prospective and multi-centre international study focusing on neurological manifestations of the largest cohort of ...
Source: Brain - March 20, 2010 Category: Neurology Authors: Jinnah, H. A., Ceballos-Picot, I., Torres, R. J., Visser, J. E., Schretlen, D. J., Verdu, A., Larovere, L. E., Chen, C.-J., Cossu, A., Wu, C.-H., Sampat, R., Chang, S.-J., de Kremer, R. D., Nyhan, W., Harris, J. C., Reich, S. G., Puig, J. G., for the Lesc Tags: Original Articles Source Type: journals

Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, a substantial number of the patients with glucose transporter-1 deficiency syndrome do not have epilepsy. Our study demonstrates that a lumbar puncture provides the diagnostic clue to glucose transporter-1 deficiency syndrome and can thereby dramatically reduce diagnostic delay to allow early start of the ketogenic diet. (Source: Brain)
Source: Brain - March 20, 2010 Category: Neurology Authors: Leen, W. G., Klepper, J., Verbeek, M. M., Leferink, M., Hofste, T., van Engelen, B. G., Wevers, R. A., Arthur, T., Bahi-Buisson, N., Ballhausen, D., Bekhof, J., van Bogaert, P., Carrilho, I., Chabrol, B., Champion, M. P., Coldwell, J., Clayton, P., Donner Tags: Original Articles Source Type: journals

Life without a cerebellumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Brain)
Source: Brain - March 20, 2010 Category: Neurology Authors: Lemon, R. N., Edgley, S. A. Tags: Scientific Commentaries Source Type: journals

'Looks like epilepsy to me!'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Brain)
Source: Brain - March 20, 2010 Category: Neurology Authors: Warlow, C. Tags: Scientific Commentaries Source Type: journals

Defining neurogenetic phenotypes (or how to compare needles in haystacks)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Brain)
Source: Brain - March 20, 2010 Category: Neurology Authors: Chinnery, P. F. Tags: Scientific Commentaries Source Type: journals

A case of arrested development of the cerebellum and its peduncles with spina bifida and other developmental peculiarities in the cord. By WB Warrington, MD MRCP, Physician to the David Lewis Northern Hospital, Liverpool, and Keith Monsarrat FRCS Edin., Surgeon to the David Lewis Northern Hospital, Liverpool. Brain 1902: 25; 444-478; with Cerebro-cerebellar agenesis in its relation to cerebellar function. By Leon Hastings Cornwall, MD, New York. Brain 1927: 50; 562-572; and Cerebellar agenesis. By Mitchell Glickstein, Department of Anatomy and Developmental Biology, University College London, UK. Brain 1994: 117; 1209-1212Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Brain)
Source: Brain - March 20, 2010 Category: Neurology Authors: Compston, A. Tags: From The Archives Source Type: journals

EditorialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Brain)
Source: Brain - March 20, 2010 Category: Neurology Authors: Compston, A. Tags: Editorial Source Type: journals

Defining and Measuring Functional Recovery from DepressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: CNS Drugs)
Source: CNS Drugs - March 20, 2010 Category: Neurology Authors: Greer, Tracy L.Kurian, Benji T.Trivedi, Madhukar H. Tags: Review Articles Source Type: journals

TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
J. Neurochem. (2010) 10.1111/j.1471-4159.2010.06644.x Oligodendrocytes are the myelin-forming cells of the CNS and guarantee proper nerve conduction. Sphingosine, one major component of myelin, has recently been identified to activate TRPM3, a member of the melastatin-related subfamily of transient receptor potential (TRP) channels. TRPM3 has been demonstrated to be expressed in brain with unknown cellular distribution. Here, we show for the first time that TRPM3 is expressed in oligodendrocytes in vitro and in vivo. TRPM3 is present during oligodendrocyte differentiation. Immunohistochemistry of adult rat brain slices rev...
Source: Journal of Neurochemistry - March 20, 2010 Category: Neurology Authors: Anja Hoffmann, Christian Grimm, Robert Kraft, Olaf Goldbaum, Arne Wrede, Christiane Nolte, Uwe-Karsten Hanisch, Christiane Richter-Landsberg, Wolfgang Brück, Helmut Kettenmann, Christian Harteneck Source Type: journals

The Cerebral Cortex Overlying Periventricular Leukomalacia: Analysis of Pyramidal NeuronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study underscores the potential role of secondary cortical injury in the encephalopathy of prematurity. (Source: Brain Pathology)
Source: Brain Pathology - March 20, 2010 Category: Neurology Authors: Sarah E. Andiman, Robin L. Haynes, Felicia L. Trachtenberg, Saraid S. Billiards, Rebecca D. Folkerth, Joseph J. Volpe, Hannah C. Kinney Source Type: journals

Gelastic seizures and the anteromesial frontal lobe: A case report and review of intracranial EEG recording and electrocortical stimulation case studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a patient whose gelastic seizures were associated with electrographic ictal activity in the mesial aspect of the right anterior frontal gyrus. The symptomatogenic area for ictal laughter in the frontal lobe may reside in the superior frontal gyrus. (Source: Epilepsia)
Source: Epilepsia - March 20, 2010 Category: Neurology Authors: Kanjana Unnwongse, Tim Wehner, William Bingaman, Nancy Foldvary-Schaefer Source Type: journals

Why teenagers find learning a dragEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The brain molecules behind a learning deficit that sets in during puberty have been identified in mice – and blocked (Source: New Scientist - The Human Brain)
Source: New Scientist - The Human Brain - March 19, 2010 Category: Neurology Source Type: journals

Surgical specialty impacts CEA outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients undergoing carotid endarterectomy have better long-term outcomes if their operation is performed by a vascular specialist, research suggests. (Source: MedWire News - Stroke)
Source: MedWire News - Stroke - March 19, 2010 Category: Neurology Source Type: news

Prolonged stimulus exposure reveals prolonged neurobehavioral response patternsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although it has been shown repeatedly that minimum response times in sensory systems can be quite short, organisms more often continue to respond to sensory stimuli over considerably longer periods of time. The continuing response to sensory stimulation may be a more realistic assessment of natural sensory responses, so we determined for how long a stimulus would evoke a response in naïve, freely moving animals. Specifically, we determined for how long such rats responded to odorants during continuous passive exposures by monitoring their sniffing with whole-body plethysmography. We found that naïve rats continue to snif...
Source: The Journal of Comparative Neurology - March 19, 2010 Category: Neurology Authors: Brett A. Johnson, Cynthia C. Woo, Yu Zeng, Zhe Xu, Edna E. Hingco, Joan Ong, Michael Leon Tags: Cover Image Source Type: journals

CDC Study Examines Rising Incidence of TBIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WASHINGTON (MedPage Today) -- Traumatic brain injury (TBI) accounts for just under a third (30.5%) of injury-related deaths in the U.S., a new CDC report on TBIs said. (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - March 19, 2010 Category: Neurology Source Type: news

Effects of physical fitness training on mortality independence and disability after stroke unclearEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence-Based Nursing is a secondary evidence journal, containing informative abstracts and expert commentaries about the best quality research from primary care medicine. Citation: Lutz BJ (2010) Effects of physical fitness training on mortality, independence and disability after stroke unclear. Evidence Based Nursing 13(1):18. Abstracted from: Saunders DH, Greig CA, Mead GE, et al. Physical fitness training for stroke patients. Cochrane Database of Systematic Reviews, Issue 4 2009 (Source: Neurological Conditions Specialist Library)
Source: Neurological Conditions Specialist Library - March 19, 2010 Category: Neurology Source Type: organizations

Antipyretic drugs do not reduce recurrences of febrile seizures in children with previous febrile seizureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence-Based Medicine is a secondary evidence journal, containing informative abstracts and expert commentaries about the best quality research from primary care medicine. Citation: Lux AL. (2010) Antipyretic drugs do not reduce recurrences of febrile seizures in children with previous febrile seizure. Evidence Based Medicine 15(1):15-6. Abstracted from: Strengell T, Uhari M, Tarkka R, et al. (2009) Antipyretic agents for preventing recurrences of febrile seizures: randomized controlled trial. Archives of pediatrics & adolescent medicine 163:799–804. (Source: Neurological Conditions Specialist Library)
Source: Neurological Conditions Specialist Library - March 19, 2010 Category: Neurology Source Type: organizations

Effects of physical fitness training on mortality independence and disability after stroke unclearEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence-Based Medicine is a secondary evidence journal, containing informative abstracts and expert commentaries about the best quality research from primary care medicine. Citation: Boysen G. (2010) Effects of physical fitness training on mortality, independence and disability after stroke unclear. Evidence Based Medicine 15(1):14-5. Abstracted from: Saunders DH, Greig CA, Mead GE, et al. Physical fitness training for stroke patients. Cochrane Database of Systematic Reviews, Issue 4, 2009 (Source: Neurological Conditions Specialist Library)
Source: Neurological Conditions Specialist Library - March 19, 2010 Category: Neurology Source Type: organizations

Innovation: Market research wants to open your skullEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Your brainwaves betray what you really think about brands and their products – and marketeers want to tune into them (Source: New Scientist - The Human Brain)
Source: New Scientist - The Human Brain - March 19, 2010 Category: Neurology Source Type: journals

Review - evidence for the effectiveness of non-surgical interventions for low back pain and radiculopathy is limitedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence-Based Medicine is a secondary evidence journal, containing informative abstracts and expert commentaries about the best quality research from primary care medicine. Citation: Rothschild, B. Review: evidence for the effectiveness of non-surgical interventions for low back pain and radiculopathy is limited. Evidence Based Medicine 2009;14:180 Abstracted from: Chou R, Atlas SJ, Stanos SP, et al. Nonsurgical interventional therapies for low back pain: a review of the evidence for an American Pain Society clinical practice guideline. Spine 2009;34:1078–93. (Source: Neurological Conditions Specialist Library)
Source: Neurological Conditions Specialist Library - March 19, 2010 Category: Neurology Source Type: organizations