Neurology Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 32.

Montelukast: Neuropsychiatric reactions in paediatric patients: 4 case reports
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Iodixanol: Contrast-induced neurotoxicity in an elderly patient: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Dexamethasone/thalidomide: Neuropathy and Cushing syndrome: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Carbamazepine: Neuroleptic malignant syndrome in a child: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Arnica: Toxic optic neuropathy following inadvertent administration: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Alfuzosin/finasteride: Hypotension and first report of ischaemic optic neuropathy: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Imine Reductases: A Comparison of Glutamate Dehydrogenase to Ketimine Reductases in the Brain.
Abstract A key intermediate in the glutamate dehydrogenase (GDH)-catalyzed reaction is an imine. Mechanistically, therefore, GDH exhibits similarities to the ketimine reductases. In the current review, we briefly discuss (a) the metabolic importance of the GDH reaction in liver and brain, (b) the mechanistic similarities between GDH and the ketimine reductases, (c) the metabolic importance of the brain ketimine reductases, and (d) the neurochemical consequences of defective ketimine reductases. Our review contains many historical references to the early work on amino acid metabolism. This work tends to be overlooke...
Source: Neurochemical Research - January 12, 2013 Category: Neuroscience Authors: Hallen A, Jamie JF, Cooper AJ Tags: Neurochem Res Source Type: research

The Role of Thyroid Hormone on Functional Organization in the Cerebellum.
Abstract The thyroid hormone (L-triiodothyronine (T(3)), thyroxine (T(4))) plays a critical role in cerebellar development. Circulating T(4) preferentially crosses the blood-brain barrier through several amino acid transporters. Then, it is taken up by astrocyte to convert into T(3), which is a bioactive ligand for nuclear thyroid hormone receptor (TR). Liganded TR regulates the expression of target genes that may play an important role in cerebellar development and function. Thus, thyroid hormone deficiency results in the change in neuronal excitability and aberrant neurotransmitter transport, which induces abnorm...
Source: Cerebellum - January 12, 2013 Category: Neuroscience Authors: Koibuchi N Tags: Cerebellum Source Type: research

Neuroimmune Regulation of Neurophysiology in the Cerebellum.
Abstract Recent studies have established the existence of an innate immune system in the central nervous system (CNS) and implicated a critical role for this system in both normal and pathological processes. Astrocytes and microglia, normal components of the CNS, are the primary cell types that comprise the innate immune system of the CNS. Basic to their role during normal and adverse conditions is the production of neuroimmune factors such as cytokines and chemokines, which are signaling molecules that initiate or coordinate downstream cellular actions. During adverse conditions, cytokines and chemokines function ...
Source: Cerebellum - January 12, 2013 Category: Neuroscience Authors: Gruol DL Tags: Cerebellum Source Type: research

Expression of Expanded CAG Transcripts Triggers Nucleolar Stress in Huntington's Disease.
Abstract Polyglutamine (polyQ) diseases, including several types of spinocerebellar ataxias and Huntington's disease (HD), are dominantly inherited neurodegenerative disorders caused by the expansion of the glutamine-coding CAG repeat in the open reading frame of the disease gene. Apart from being translated to produce toxic elongated polyQ domain-containing disease proteins, transcribed expanded CAG RNAs per se also exert toxicity in polyQ degeneration. In the R6/2 HD transgenic mouse model, expanded mutant Huntingtin (Htt) transcripts were found to physically interact with nucleolin (NCL), a nucleolar protein tha...
Source: Cerebellum - January 12, 2013 Category: Neuroscience Authors: Tsoi H, Chan HY Tags: Cerebellum Source Type: research

Interleukin-1 beta C-511T polymorphism modulates functional connectivity of anterior midcingulate cortex in non-demented elderly Han males.
This study investigates the effects of IL-1 beta C-511T polymorphism on the functional connectivity of the cognitive division of the cingulate cortex [i.e., the anterior midcingulate (aMCC)] in non-demented Han elderly people and tests the hypothesis that T/T carriers are associated with lowered FC. Non-demented elderly males (n = 95) received resting MRI scanning, genotyping, and cognitive evaluation using the cognitive abilities screening instrument (CASI) and the Wechsler digit span task test. The functional connectivity map in each subject was derived based on positive correlations of low-frequency fMRI fluctuations ...
Source: Brain Structure and Function - January 12, 2013 Category: Neuroscience Authors: Tu PC, Su TP, Huang CC, Yang AC, Yeh HL, Hong CJ, Liou YJ, Liu ME, Lin CP, Tsai SJ Tags: Brain Struct Funct Source Type: research

The Migration of Neural Progenitor Cell Mediated by SDF-1 is NF-κB/HIF-1α Dependent upon Hypoxia.
CONCLUSIONS: Hypoxic induction of SDF-1 is reliant upon NF-κB and HIF-1α. There is a cross-talk between HIF-1α and NF-κB, both HIF-1α and SDF-1 are downstream targets of NF-κB in hypoxia condition. PMID: 23311761 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 12, 2013 Category: Neuroscience Authors: Yin W, Ma L, Zhang J, Huang K, Yang Q, Guo YY, Liu SB, Liu YH, Wu YM Tags: CNS Neurosci Ther Source Type: research

A brief history of hair cell regeneration research and speculations on the future.
This article is part of a Special Issue entitled "Inner Ear Development and Regeneration". PMID: 23321648 [PubMed - as supplied by publisher]
Source: Hearing Research - January 12, 2013 Category: Audiology Authors: Rubel EW, Furrer SA, Stone JS Tags: Hear Res Source Type: research

In vitro inhibition of Japanese encephalitis virus replication by capsid-targeted virus inactivation.
Abstract Japanese encephalitis virus (JEV) is a leading member of the mosquito-transmitted flavivirus family, and is mainly distributed in China, India and South East Asia, where it can cause the central nervous system disease with irreversible neurological damage in humans and animals. Few effective anti viral drugs are currently available against JEV infections. To explore the feasibility of using capsid-targeted viral inactivation (CTVI), as an anti viral strategy against JEV infection, a plasmid pcDNA-Cap-SNase was constructed for expressing a fusion protein of JEV capsid (Cap) and Staphylococcus aureus nucleas...
Source: Antiviral Research - January 12, 2013 Category: Virology Authors: Pang R, He DN, Zhou B, Liu K, Zhao J, Zhang XM, Chen PY Tags: Antiviral Res Source Type: research

Reduction in swimming performance in juvenile rainbow trout (Oncorhynchus mykiss) following sublethal exposure to pyrethroid insecticides.
Abstract While the lethal toxicity of pyrethroid insecticides to fish is well documented, their sublethal physio-behavioral effects remain poorly characterized. Known pyrethroid-associated changes to insect neuromuscular function may translate into similar effects in fish, thereby altering swimming ability and affecting foraging, predator avoidance, and migration. Three experiments were conducted using critical (U(crit)) and burst (U(max)) swimming speed to assess the sublethal effects of the pyrethroids permethrin and deltamethrin in juvenile rainbow trout (Oncorhynchus mykiss). Fish were exposed to deltamethrin (...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 12, 2013 Category: Biochemistry Authors: Goulding AT, Shelley LK, Ross PS, Kennedy CJ Tags: Comp Biochem Physiol C Toxicol Pharmacol Source Type: research

Automated Spectral EEG Analyses of Premature Infants during the First Three Days of Life Correlated with Developmental Outcomes at 24 Months.
Conclusion: This study found that extremely premature infants with poor developmental outcomes had significantly lower tABP values in their first days of life compared to infants from the same group with normal outcomes. This method may be useful in predicting later outcomes in extremely premature infants and has the advantage of being automated. PMID: 23327994 [PubMed - as supplied by publisher]
Source: Neonatology - January 12, 2013 Category: Perinatology & Neonatology Authors: Schumacher EM, Larsson PG, Sinding-Larsen C, Aronsen R, Lindeman R, Skjeldal OH, Stiris TA Tags: Neonatology Source Type: research

Neuronal metabolomics by ion mobility mass spectrometry: cocaine effects on glucose and selected biogenic amine metabolites in the frontal cortex, striatum, and thalamus of the rat.
We report results of studies of global and targeted neuronal metabolomes by ambient pressure ion mobility mass spectrometry. The rat frontal cortex, striatum, and thalamus were sampled from control nontreated rats and those treated with acute cocaine or pargyline. Quantitative evaluations were made by standard additions or isotopic dilution. The mass detection limit was ∼100 pmol varying with the analyte. Targeted metabolites of dopamine, serotonin, and glucose followed the rank order of distribution expected between the anatomical areas. Data was evaluated by principal component analysis on 764 common metabolites (iden...
Source: Analytical and Bioanalytical Chemistry - January 12, 2013 Category: Chemistry Authors: Kaplan KA, Chiu VM, Lukus PA, Zhang X, Siems WF, Schenk JO, Hill HH Tags: Anal Bioanal Chem Source Type: research

Investigation of neuroleptics and other aromatic compounds by laser-based ion mobility mass spectrometry.
Abstract Laser-based ion mobility (IM) spectrometry was used for the detection of neuroleptics and PAH. A gas chromatograph was connected to the IM spectrometer in order to investigate compounds with low vapour pressure. The substances were ionized by resonant two-photon ionization at the wavelengths λ = 213 and 266 nm and pulse energies between 50 and 300 μJ. Ion mobilities, linear ranges, limits of detection and response factors are reported. Limits of detection for the substances are in the range of 1-50 fmol. Additionally, the mechanism of laser ionization at atmospheric pressure was investigated. Firs...
Source: Analytical and Bioanalytical Chemistry - January 12, 2013 Category: Chemistry Authors: Brendler C, Riebe D, Ritschel T, Beitz T, Löhmannsröben HG Tags: Anal Bioanal Chem Source Type: research

The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin
Abstract The functions of members of the large family of transcriptional repressors, the KRAB domain zinc finger proteins, are not well described. We have identified a new member of this family, Zfp157, as a downstream target of the transcription factor Stat6 in mammary gland. Using a gene‐trap approach, we have generated mice harbouring a Zfp157‐LacZ reporter gene. We have characterised the expression of this reporter during mouse embryogenesis and show that it is expressed in the epiblast and subsequently in a number of embryonic tissues including brain, ovary, intestine, kidney, lung, mammary gland and hair follicle...
Source: genesis - January 12, 2013 Category: Genetics & Stem Cells Authors: Carrie H Oliver, Jennifer Nichols, Christine J Watson Tags: Letter Source Type: research

Novel aspects of parenchymal–mesenchymal interactions: from cell types to molecules and beyond
Mesenchymal stem or stromal cells (MSCs) were initially isolated from the bone marrow and received their name on the basis of their ability to differentiate into multiple lineages such as bone, cartilage, fat and muscle. However, more recent studies suggest that MSCs residing in perivascular compartments of the small and large blood vessels play a regulatory function supporting physiologic and pathologic responses of parenchymal cells, which define the functional representation of an organ or tissue. MSCs secrete or express factors that reach neighbouring parenchymal cells via either a paracrine effect or a direct cell‐t...
Source: Cell Biochemistry and Function - January 12, 2013 Category: Biochemistry Authors: Carolina Bluguermann, Ling Wu, Frank Petrigliano, David McAllister, Santiago Miriuka, Denis A. Evseenko Tags: Review Article Source Type: research

Human omentum fat‐derived mesenchymal stem cells transdifferentiates into pancreatic islet‐like cluster
This study revealed the in vitro differentiation potency of omentum fat stem cells into pancreatic islet‐like clusters. However, further research pursuits exploring its in vivo endocrine efficacy would make omentum fat stem cells a superior source for β‐cell replacement therapy. Copyright © 2013 John Wiley & Sons, Ltd.
Source: Cell Biochemistry and Function - January 12, 2013 Category: Biochemistry Authors: M Dhanasekaran, S Indumathi, R Harikrishnan, Rashmi Mishra, RP Lissa, J S Rajkumar, D Sudarsanam Tags: Research Article Source Type: research

Male‐specific alteration in excitatory postsynaptic development and social interaction in prenatal valproic acid exposure model of autism spectrum disorder
Abstract Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by three main behavioral symptoms including social deficits, impaired communication, and stereotyped and repetitive behaviors. ASD prevalence shows gender bias to male. Prenatal exposure to valproic acid (VPA), a drug used in epilepsy and bipolar disorder, induces autistic symptoms in both human and rodents. As we reported previously, prenatally VPA‐exposed animals at E12 showed impairment in social behavior without any overt reproductive toxicity. Social interactions were not significantly different between in male and female rat...
Source: Journal of Neurochemistry - January 12, 2013 Category: Neurology Authors: Ki Chan Kim, Pitna Kim, Hyo Sang Go, Chang Soon Choi, Jin Hee Park, Hee Jin Kim, Se Jin Jeon, Ike Campomayor Pena, Seol‐Heui Han, Jae Hoon Cheong, Jong Hoon Ryu, Chan Young Shin Tags: Original Article Source Type: research

Neuronal Galectin‐4 is required for axon growth and for the organization of axonal membrane L1 delivery and clustering
We describe here that galectin‐4 (Gal‐4), a lectin highly expressed in gastrointestinal tissues and involved in epithelial glycoprotein transport, is expressed by hippocampal and cortical neurons where it is sorted to discrete segments of the axonal membrane in a microtubule‐ and sulfatide‐dependent manner. Gal‐4 knockdown retards axon growth, an effect that can be rescued by recombinant Gal‐4 addition. This Gal‐4 reduction, as inhibition of sulfatide synthesis does, lowers the presence and clustered organization of axon growth‐promoting molecule NCAM L1 at the axon membrane. Furthermore, we find that Gal�...
Source: Journal of Neurochemistry - January 12, 2013 Category: Neurology Authors: Silvia Velasco, Natalia Díez‐Revuelta, Teresa Hernández‐Iglesias, Herbert Kaltner, Sabine André, Hans‐Joachim Gabius, José Abad‐Rodríguez Tags: Original Article Source Type: research

Age‐dependent dystonia in striatal Gγ7 deficient mice is reversed by the dopamine D2 receptor agonist pramipexole
Abstract Gγ7 is enriched in striatum and forms a heterotrimeric complex with Gαolf/Gβ, which is coupled to D1 receptor (D1R). Here we attempted to characterize the pathophysiological, neurochemical and pharmacological features of mice deficient of Gγ7 gene. Gγ7 knockout mice exhibited age‐dependent deficiency in rotarod behavior and increased dystonia‐like clasping reflex without loss of striatal neurons. The neurochemical basis for the motor manifestations using immunoblot analysis revealed increased levels of D1R, ChAT and NMDA receptor subunits (NR1 and NR2B) concurrent with decreased levels of D2R and Gαolf, ...
Source: Journal of Neurochemistry - January 12, 2013 Category: Neurology Authors: Keita Sasaki, Tatsuro Yamasaki, Idowu O Omotuyi, Masayoshi Mishina, Hiroshi Ueda Tags: Original Article Source Type: research

The ‘Mickey Mouse ears’ sign: a bilateral cerebral peduncular infarction
Source: European Journal of Neurology - January 12, 2013 Category: Neurology Authors: Y. Asakawa, K. Suzuki, H. Takekawa, M. Okamura, T. Komagamine, A. Kawasaki, M. Yamamoto, T. Sada, K. Hirata Tags: Letter to the Editor Source Type: research

Restless legs syndrome in the emergency room
Source: European Journal of Neurology - January 12, 2013 Category: Neurology Authors: M. Manconi, S. Fulda Tags: Letter to the Editor Source Type: research

Severe exacerbation of undiagnosed restless legs syndrome presenting as a movement disorder emergency
Source: European Journal of Neurology - January 12, 2013 Category: Neurology Authors: S. H. Mehta, D. D. Dees, J. C. Morgan, K. D. Sethi Tags: Letter to the Editor Source Type: research

Calendar
Source: European Journal of Neurology - January 12, 2013 Category: Neurology Tags: Miscellaneous Source Type: research

Erratum
Source: European Journal of Neurology - January 12, 2013 Category: Neurology Tags: Erratum Source Type: research

Technique for sparing previously irradiated critical normal structures in salvage proton craniospinal irradiation
Conclusions: Proton craniospinal irradiation can be adapted to provide complete sparing of previously irradiated OARs. This technique may extend the option of reirradiation to patients otherwise deemed ineligible for further radiotherapy due to prior dose to critical normal structures.
Source: Radiation Oncology - January 12, 2013 Category: Cancer & Oncology Authors: Mark McDonaldMark WolanskiJoseph SimmonsJeffrey Buchsbaum Source Type: research

Surrogate markers for cerebral blood flow correlate with [18F]‐fallypride binding potential at dopamine D2/3 receptors in human striatum
Abstract Positron emission tomography (PET) with the high affinity dopamine D2/3 receptor ligand [18F]‐fallypride affords estimates of the binding potential (BPND) in extra‐striatal regions of low receptor abundance, but the sufficient recording time for accurate measurements in striatum has been called into question. We have earlier argued that transient equilibrium measurements are obtained in striatum with [18F]‐fallypride PET recordings of 3 h duration, which may be the practical limit for clinical investigations without interrupted scanning. However, the high extraction fraction of [18F]‐fallypride predicts fl...
Source: Synapse - January 12, 2013 Category: Neurology Authors: Paul Cumming, Guoming Xiong, Christian LA Fougère, Axel Rominger, Peter Bartenstein, Hans‐Georg Buchholz, Markus Piel, Frank Rösch, Gerhard Gründer, Ingo Vernaleken Tags: Short Communication Source Type: research

Task-related functional connectivity in autism spectrum conditions: an EEG study using wavelet transform coherence
Conclusions: Interhemispheric coherence is reduced in people with ASC, in a time and frequency specific manner, during visual perception and categorization of both social and inanimate stimuli and this reduction in coherence is widely dispersed across the brain.Results of within-group task comparisons may reflect an impairment in task differentiation in people with ASC relative to typically developing individuals.Overall, the results of this research support the value of WTC in examining the time-frequency microstructure of task-related interhemispheric EEG coherence in people with ASC.
Source: BioMed Central - January 12, 2013 Category: Journals (General) Authors: Ana CatarinoAlexandre AndradeOwen ChurchesAdam P WagnerSimon Baron-CohenHoward Ring Source Type: research

Fibroblast Growth Factor Signaling Regulates Neurogenesis at Multiple Stages in the Embryonic Olfactory Epithelium
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 11, 2013 Category: Stem Cells Tags: article Source Type: research

Surgical Technique and Recurrence in Cholesteatoma: A Meta-Analysis
Audiol Neurotol 2013;18:135–142 (DOI:10.1159/000346140)
Source: Audiology and Neurotology - January 11, 2013 Category: Audiology Source Type: research

Relationship between disease-specific structures of amyloid fibrils and their mechanical properties
Gwonchan Yoon, Young Kab Kim, Kilho Eom, and Sungsoo Na It has recently been reported that the mechanical behavior of prion nanofibrils may play a critical role in expression of neurodegenerative diseases. In this work, we have studied the mechanical behavior of HET-s prion nanofibrils using an elastic network model. We have shown that the mechanical pro ... [Appl. Phys. Lett. 102, 011914 (2013)] published Fri Jan 11, 2013.
Source: Applied Physics Letters - January 11, 2013 Category: Physics Source Type: research

A conversation with Medical Society President Bart Grelinger
Spend any time at all with Wichita neurologist Bart Grelinger, and it’s easy to see that he is passionate about medicine. The business of running an independent medical practice, however? Not so much. Grelinger is a partner at Neurology Consultants of Kansas and the 2013 president of the Medical Society of Sedgwick County. I sat down with Grelinger Friday morning for a get-to-know-you session. I left the hourlong meeting with multiple pages of notes and with two key takeaways: One, Grelinger…
Source: bizjournals.com Health Care:Biotechnology headlines - January 11, 2013 Category: Biotechnology Authors: Josh Heck Source Type: research

Destination Specificity
During brain development, some types of neurons migrate from where they are born to their final functional locations. Some neurons migrate radially, from the inside to the outside, while others … [Read more]
Source: This Week in Science - January 11, 2013 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research

[Report] Ezh2 Orchestrates Topographic Migration and Connectivity of Mouse Precerebellar Neurons
During brain development, epigenetic mechanisms allow tangentially migrating neurons to retain topographical organization.Authors: Thomas Di Meglio, Claudius F. Kratochwil, Nathalie Vilain, Alberto Loche, Antonio Vitobello, Keisuke Yonehara, Steven M. Hrycaj, Botond Roska, Antoine H. F. M. Peters, Anne Eichmann, Deneen Wellik, Sebastien Ducret, Filippo M. Rijli
Source: Science: Current Issue - January 11, 2013 Category: Science Authors: Thomas Di Meglio Source Type: research

[Report] Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain
The expression of metabotropic glutamate receptors in brain astrocytes is down-regulated in early postnatal development. [Also see Perspective by Grosche and Reichenbach]Authors: Wei Sun, Evan McConnell, Jean-Francois Pare, Qiwu Xu, Michael Chen, Weiguo Peng, Ditte Lovatt, Xiaoning Han, Yoland Smith, Maiken Nedergaard
Source: Science: Current Issue - January 11, 2013 Category: Science Authors: Wei Sun Source Type: research

[Perspective] Neuroscience: Developmental Refining of Neuroglial Signaling?
A change in glutamate receptor expression in adult glial cells advances the current model of how glia regulate neuronal activity. [Also see Report by Sun et al.]Authors: Antje Grosche, Andreas Reichenbach
Source: Science: Current Issue - January 11, 2013 Category: Science Authors: Antje Grosche Source Type: research

[Perspective] Neuroscience: Specialized But Flexible
Hawk moths are specialized to recognize the odors from specific plants but can learn to recognize and follow other plant odors. [Also see Report by Riffell et al.]Authors: Markus Knaden, Bill S. Hansson
Source: Science: Current Issue - January 11, 2013 Category: Science Authors: Markus Knaden Source Type: research

‘Augustine’
Eur Neurol 2013;69:226–228 (DOI:10.1159/000346032)
Source: European Neurology - January 11, 2013 Category: Neurology Source Type: research

Does Constant Googling Really Make You Stupid? [Excerpt]
Editor's note: The following is an excerpt from the book, Twentysomething: Why Do Young Adults Seem Stuck ? , by Robin Marantz Henig and Samantha Henig (Hudson Street Press, 2012). Copyright © Robin Marantz Henig and Samantha Henig. Robin Henig has written several articles for Scientific American, including "When Does Life Belong to the Living?" and "How Depressed Is That Mouse?" . [More]
Source: Scientific American - Official RSS Feed - January 11, 2013 Category: Science Tags: Mind & Brain,Mind Brain,Technology,Computing,Neuroscience,Psychology,Thought Cognition,Communications,Biology,More Science Source Type: research

Why Are Chimps Stronger Than Humans? - Instant Egghead
The last several years have seen a number of horrific maulings at the hands of chimpanzees. How can animals that share 99 percent of their genes with us, yet are only a fraction of our weight, possess such amazing strength?
Source: Scientific American - Official RSS Feed - January 11, 2013 Category: Science Tags: Biology,Neuroscience,Health Source Type: research

Pompeii "Wall Posts" Reveal Ancient Social Networks
Think of it as the earliest version of the Facebook wall post: Ancient Pompeii residents revealed their social networks through graffiti on actual walls. [More]
Source: Scientific American - Official RSS Feed - January 11, 2013 Category: Science Tags: More Science,History of Science,Mind & Brain,Communications,Evolution,Language Linguistics,Language Linguistics,Archaeology Paleontology Source Type: research

In vitro screening of psychoactive drugs.
Abstract Prior to the designation of illegal drugs (psychoactive drugs) by prefectural regulations, the Tokyo Metropolitan Government conducts surveys on the risk of drugs, reports the results to the governor through the Tokyo Metropolitan Government Advisory Committee on Illegal Drugs, an affiliated organization, and provides the central government with information. The Tokyo Metropolitan Institute of Public Health conducts identification of the constituents of drugs and biological effect tests to help the committee analyze and assess information on the risks of drugs. Narcotics and stimulants increase the concent...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 11, 2013 Category: Drugs & Pharmacology Authors: Satoh K, Ogata A Tags: Yakugaku Zasshi Source Type: research

In vivo screening of illegal drug.
Abstract The neuro-behavioral observation scorebook that improved the previous observation methods of Irwin was followed, the test material was administered to 5 mice per each group, and the mean value of the obtained score was determined. The behavior of a normal animal was assumed to be point 0, animals showing suppressive behavior were scored in the minus region, and animals that showed excitement behavior were scored in the plus region. Each score was divided into three stages, according to the level of strength of the biological effect. The score of each observation item was totaled, and the level of the stren...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 11, 2013 Category: Drugs & Pharmacology Authors: Ogata A, Satoh K, Fuwa T, Tanaka T, Nagasawa A, Yuzawa K, Yano N, Ando H, Kubo Y, Takahashi H, Ohyama K, Miyazawa M, Kojima T Tags: Yakugaku Zasshi Source Type: research

The Norwegian Brain Council ('Hjernerådet') - united efforts are necessary!
Abstract There is a strong tradition of neuroscience in Norway, and Norwegian neurologists have been actively involved in developing partnerships between all those who recognize the importance of the brain and of brain diseases. It was therefore unsurprising that Norwegian neurologists took the initiative in establishing the Norwegian Brain Council (NBC). NBC was founded in 2007 and now comprises 27 organizations and institutions. It includes all those who work with brain research and brain diseases in Norway, as well as all relevant user organizations. Industries and businesses that are related to brain disease ma...
Source: Acta Neurologica Scandinavica. Supplementum - January 11, 2013 Category: Neurology Authors: Gjerstad L, Gilhus NE, Stovner LJ, Hoff JM Tags: Acta Neurol Scand Suppl Source Type: research

Common imitators of epilepsy.
Abstract Many episodic phenomena involving motor, sensory, autonomic, and behavioral functions may imitate epilepsy. The aim of this article is to focus on the various manifestations and the diagnostic and therapeutic challenges of the most common of these disorders, as well as their relationship to emotional aspects. Syncope is caused by reduced global cerebral perfusion. Convulsive movements are sometimes released from subcortical structures, but do not follow the characteristic sequence of tonic-clonic seizures, and postictal symptoms are minimal. Hyperventilation attacks are caused by the metabolic consequences...
Source: Acta Neurologica Scandinavica. Supplementum - January 11, 2013 Category: Neurology Authors: Brodtkorb E Tags: Acta Neurol Scand Suppl Source Type: research

Reduced immunoglobulin levels in epilepsy patients treated with levetiracetam, lamotrigine, or carbamazepine.
CONCLUSIONS: Low levels of immunoglobulins were found in patients with epilepsy treated with LTG or CBZ. As our group of patients consisted of otherwise healthy young adults, one should be especially aware of a possible effect of AEDs on immunoglobulin levels when treating selected patient groups, for example immunocompromised patients. Immunoglobulin concentrations should be measured in patients treated with LTG or CBZ who experience recurrent infections, and a change in medication should be considered. PMID: 23190286 [PubMed - in process]
Source: Acta Neurologica Scandinavica. Supplementum - January 11, 2013 Category: Neurology Authors: Svalheim S, Mushtaq U, Mochol M, Luef G, Rauchenzauner M, Frøland SS, Taubøll E Tags: Acta Neurol Scand Suppl Source Type: research