Neurology This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Clinical and MRI predictors of response to interferon‐beta and glatiramer acetate in relapsing–remitting multiple sclerosis patients
ConclusionA lower baseline MRI and clinical activity have been identified as predictors of DMT efficacy in patients with RRMS in routine clinical practice. Evaluation of clinical and MRI activity at 1 year is recommended to monitor patients over time.
Source: European Journal of Neurology - February 20, 2013 Category: Neurology Authors: M. Romeo, F. Martinelli‐Boneschi, M. Rodegher, F. Esposito, V. Martinelli, G. Comi, Tags: Original Article Source Type: research

Animal Models of Brain Tumors Ricardo Martinez Murillo, Alfredo Martinez, (eds). New York, Heidelberg, Dortrecht, London: Humana Press – Springer, 2012, 391 pp., Price: US$ 139.00, ISBN 978‐1‐62703‐208‐7.
Source: European Journal of Neurology - February 20, 2013 Category: Neurology Authors: K. A. Jellinger Tags: Book Review Source Type: research

Laughing Headache With Giant Pacchionian Granulations
We report a single case of severe headache, provoked almost exclusively by outbursts of laughing, where venous magnetic resonance imaging revealed the presence of giant Pacchioni granulations in both right and transverse sinuses. Reviewing published cases of laughing headache, we discuss possible mechanisms of pain and the role of giant Pacchionian granulations.
Source: Headache: The Journal of Head and Face Pain - February 20, 2013 Category: Neurology Authors: Pierric Giraud, Olivier Segal, Sylvie Chauvet Tags: Clinical Correspondence Source Type: research

Migraine After Sneezing: Pathophysiological Considerations, Focused on the Difference With Coughing
We describe a patient who suffered 3 headache attacks after sneezing, each fulfilling criteria of migraine without aura. Sneezing as a specific trigger for migraine has not been described before. DiscussionThe differential diagnosis of acute headache after sneezing (eg, subarachnoid hemorrhage and reversible cerebral vasoconstriction), and the differences between migraine after sneezing and “benign cough headache” are discussed. We conclude that a pathophysiological association between migraine and sneezing might exist and hypothesize on underlying mechanisms.
Source: Headache: The Journal of Head and Face Pain - February 20, 2013 Category: Neurology Authors: Willebordus P.J. Oosterhout, Joost Haan Tags: Brief Communication Source Type: research

Ambulatory Blood Pressure Monitoring in Patient With Hypnic Headache: A Case Study
Source: Headache: The Journal of Head and Face Pain - February 20, 2013 Category: Neurology Authors: Raimundo P. Silva‐Néto, Silvya N. Bernardino Tags: Clinical Correspondence Source Type: research

Hypoplasia of the spinal cord in a case of fetal akinesia/arthrogryposis sequences
Lethal congenital contracture syndrome (LCCS) is an autosomal recessive disease, characterized by the fetal akinesia phenotype, with multiple contractures of joints and degeneration of motor neurons in the spinal cord as the main neuropathological findings [1, 2, 3, 4, 5]. Recent studies have shown that the defective gene underlying the lethal motor neuron syndrome LCCS1 is the mRNA export mediator GLE1 [6, 7]. Herein we report a case showing generalized arthrogryposis and severe hypoplasia of the spinal cord, but without any definitive mutations in the GLE1 gene. The subject of this study was a Japanese female baby, showi...
Source: Neuropathology and Applied Neurobiology - February 20, 2013 Category: Neurology Authors: Kyoto Itoh, Ritsuko Pooh, Yonehiro Kanemura, Mami Yamasaki, Shinji Fushiki Tags: Scientific Correspondence Source Type: research

Meeting materials posted for February 22, 2013 Neurological Devices Panel of the Medical Devices Advisory Committee Meeting
Source: Food and Drug Adminstration (FDA): CDRHNew - February 20, 2013 Category: Medical Equipment Source Type: news

Relationship between postprandial metabolomics and colon motility in children with constipation
Conclusions & InferencesThis is the first study to examine postprandial metabolic changes in children and also to correlate changes in specific metabolites with colonic motility. The results suggest possible metabolic pathways associated with motility and identify potential targets for the treatment of constipation.
Source: Neurogastroenterology and Motility - February 20, 2013 Category: Gastroenterology Authors: L. Rodriguez, L. D. Roberts, J. LaRosa, N. Heinz, R. Gerszten, S. Nurko, A. M. Goldstein Tags: Original Article Source Type: research

Advantages of an Antagonist: Bicuculline and Other GABA Antagonists
Abstract The convulsant alkaloid bicuculline continues to be investigated more than 40 years after the first publication of its action as an antagonist of receptors for the inhibitory neurotransmitter GABA. This historical perspective highlights key aspects of the discovery of bicuculline as a GABA antagonist and the sustained interest in this and other GABA antagonists. The exciting advances in the molecular biology, pharmacology and physiology of GABA receptors provide a continuing stimulus for the discovery of new antagonists with increasing selectivity for the myriad of GABA receptor subclasses. Interesting GABA antago...
Source: British Journal of Pharmacology - February 20, 2013 Category: Drugs & Pharmacology Authors: Graham A.R. Johnston Tags: Review Article Source Type: research

CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?
Summary The neuropeptide calcitonin gene‐related peptide (CGRP) is reported to play an important role in migraine. It is expressed throughout the trigeminovascular system. Antagonists targeting the CGRP receptor have been developed and have shown efficacy in clinical trials for migraine. However, no CGRP antagonist is yet approved for treating this condition. The molecular composition of the CGRP receptor is unusual because it comprises two subunits. One is a G protein‐coupled receptor (GPCR), the calcitonin receptor‐like receptor (CLR). This associates with receptor activity‐modifying protein (RAMP) 1 to yield a f...
Source: British Journal of Pharmacology - February 20, 2013 Category: Drugs & Pharmacology Authors: C S Walker, D L Hay Tags: Review Article Source Type: research

The macrocyclic tetrapeptide [D‐Trp]CJ‐15,208 produces short acting κ opioid receptor antagonism in the CNS after oral administration
Conclusions and ImplicationsThe macrocyclic tetrapeptide [D‐Trp]CJ‐15,208 is a short‐duration κ opioid receptor antagonist with weak KOR agonist activity that is active after oral administration and demonstrates blood‐brain barrier permeability. These data validate the use of systemically active peptides such as [D‐Trp]CJ‐15,208 as potentially useful therapeutics.
Source: British Journal of Pharmacology - February 20, 2013 Category: Drugs & Pharmacology Authors: Shainnel O. Eans, Michelle L. Ganno, Kate J. Reilley, Kshitij A. Patkar, Sanjeewa N. Senadheera, Jane V. Aldrich, Jay P. McLaughlin Tags: Research Paper Source Type: research

Genome-wide imaging study identifies new gene associated with Alzheimer's plaques
(Indiana University) A study combining genetic data with brain imaging, designed to identify genes associated with the amyloid plaque deposits found in Alzheimer's disease patients, has not only identified the APOE gene -- long associated with development of Alzheimer's -- but has uncovered an association with a second gene, called BCHE.
Source: EurekAlert! - Medicine and Health - February 20, 2013 Category: Global & Universal Source Type: news

Secrets of human speech uncovered
(University of California - San Francisco) A team of researchers at UC San Francisco has uncovered the neurological basis of speech motor control, the complex coordinated activity of tiny brain regions that controls our lips, jaw, tongue and larynx as we speak.
Source: EurekAlert! - Medicine and Health - February 20, 2013 Category: Global & Universal Source Type: news

Scripps Florida scientist awarded prestigious Javits Neuroscience Investigator Award
(Scripps Research Institute) Ron Davis, PhD, chair of the Neuroscience Department on the Florida campus of The Scripps Research Institute, has been selected to receive a prestigious $3.5 million Jacob K. Javits Neuroscience Investigator Award for his work on the complex biology of memory formation and the disorders that disrupt it.
Source: EurekAlert! - Medicine and Health - February 20, 2013 Category: Global & Universal Source Type: news

Human cognition depends upon slow-firing neurons
(Yale University) Good mental health and clear thinking depend upon our ability to store and manipulate thoughts on a sort of "mental sketch pad." In a new study, Yale School of Medicine researchers describe the molecular basis of this ability -- the hallmark of human cognition -- and describe how a breakdown of the system contributes to diseases such as schizophrenia and Alzheimer's disease.
Source: EurekAlert! - Social and Behavioral Science - February 20, 2013 Category: Global & Universal Source Type: news

Children with brain lesions able to use gestures important to language learning
(Georgia State University) Children with brain lesions suffered before or around the time of birth are able to use gestures -- an important aspect of the language learning process -- to convey simple sentences.
Source: EurekAlert! - Social and Behavioral Science - February 20, 2013 Category: Global & Universal Source Type: news

Non-suicidal self-injury and emotion regulation: a review on facial emotion recognition and facial mimicry
Non-suicidal self-injury (NSSI) is an increasingly prevalent, clinically significant behavior in adolescents and can be associated with serious consequences for the afflicted person. Emotion regulation is considered its most frequent function. Because the symptoms of NSSI are common and cause impairment, it will be included in Section 3 disorders as a new disorder in the revised Diagnostic and Statistical Manual of Mental Disorders (DSM-5). So far, research has been conducted mostly with patients with borderline personality disorder (BPD) showing self-injurious behavior. Therefore, for this review the current state of rese...
Source: Child and Adolescent Psychiatry and Mental Health - February 20, 2013 Category: Psychiatry Authors: Tina In-AlbonMartina BürliClaudia RufMarc Schmid Source Type: research

Attentional enhancement of spatial resolution: linking behavioural and neurophysiological evidence
Nature Reviews Neuroscience 14, 188 (2013). doi:10.1038/nrn3443 Authors: Katharina Anton-Erxleben & Marisa Carrasco Attention allows us to select relevant sensory information for preferential processing. Behaviourally, it improves performance in various visual tasks. One prominent effect of attention is the modulation of performance in tasks that involve the visual system's spatial resolution. Physiologically, attention modulates neuronal responses and alters
Source: Nature Reviews Neuroscience - February 20, 2013 Category: Neuroscience Authors: Katharina Anton-ErxlebenMarisa Carrasco Tags: Review Source Type: research

Long-distance retrograde neurotrophic factor signalling in neurons
Nature Reviews Neuroscience 14, 177 (2013). doi:10.1038/nrn3253 Authors: Anthony W. Harrington & David D. Ginty The specialized architecture of neurons necessitates unique modes of intracellular communication to allow for cell survival, the ability to detect and respond to injury and aspects of neuronal development, such as axon and dendrite growth, plasticity, and synapse and circuit formation. Many of these neuronal
Source: Nature Reviews Neuroscience - February 20, 2013 Category: Neuroscience Authors: Anthony W. HarringtonDavid D. Ginty Tags: Review Source Type: research

Learning and memory: Austerity measures for memory
Nature Reviews Neuroscience 14, 159 (2013). doi:10.1038/nrn3462 Author: Sian Lewis Under conditions of reduced food availability, the Drosophila melanogaster brain responds by switching from a more energy-demanding memory consolidation process involving protein synthesis to a less costly process that does not.
Source: Nature Reviews Neuroscience - February 20, 2013 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research

Cell biology of the neuron: Fuelling transport
Nature Reviews Neuroscience 14, 156 (2013). doi:10.1038/nrn3463 Author: Darran Yates The ATP required for the fast axonal transport of vesicles may be generated by vesicle-tethered glycolytic machinery.
Source: Nature Reviews Neuroscience - February 20, 2013 Category: Neuroscience Authors: Darran Yates Tags: Research Highlight Source Type: research

Effects of Tai Chi training on exercise capacity and quality of life in patients with chronic heart failure: a meta-analysis
Conclusions TC may improve QoL in patients with CHF and could be considered for inclusion in cardiac rehabilitation programmes. However, there is currently a lack of evidence to support TC altering other important clinical outcomes. Further larger RCTs are urgently needed to investigate the effects of TC.
Source: European Journal of Heart Failure - February 20, 2013 Category: Cardiology Authors: Pan, L., Yan, J., Guo, Y., Yan, J. Tags: TREATMENT Source Type: research

First signals from brain nerve cells with ultrathin nanowires
(Lund University) Electrodes operated into the brain are today used in research and to treat diseases such as Parkinson's. However, their use has been limited by their size. At Lund University in Sweden, researchers have, for the first time, succeeded in implanting an ultrathin nanowire-based electrode and capturing signals from the nerve cells in the brain of a laboratory animal.
Source: EurekAlert! - Medicine and Health - February 20, 2013 Category: Global & Universal Source Type: news

Dopamine Receptors in Human Embryonic Stem Cell Neurodifferentiation
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - February 19, 2013 Category: Stem Cells Tags: article Source Type: research

Deployment-Related Traumatic Brain Injury Among Operation Enduring Freedom/Operation Iraqi Freedom Veterans: Associations with Mental and Physical Health by Gender
Journal of Women's Health , Vol. 0, No. 0.
Source: Journal of Women - February 19, 2013 Category: OBGYN Tags: article Source Type: research

Long‐Standing Balancing Selection in the THBS4 Gene: Influence on Sex‐Specific Brain Expression and Grey Matter Volumes in Alzheimer Disease
ABSTRACT The THBS4 gene encodes a glycoprotein involved in inflammatory responses and synaptogenesis. THBS4 is expressed at higher levels in the brain of humans compared to non‐human primates, and the protein accumulates in β‐amyloid plaques. We analysed THBS4 genetic variability in humans and show that two haplotypes (hap1 and hap2) are maintained by balancing selection and modulate THBS4 expression in lymphocytes. Indeed, the balancing selection region covers a predicted transcriptional enhancer. In humans, but not in macaques and chimpanzees, THBS4 brain expression increases with age, and variants in the balancing ...
Source: Human Mutation - February 19, 2013 Category: Genetics & Stem Cells Authors: Cagliani Rachele, Franca R. Guerini, Rubio‐Acero Raquel, Baglio Francesca, Forni Diego, Agliardi Cristina, Griffanti Ludovica, Fumagalli Matteo, Pozzoli Uberto, Riva Stefania, Calabrese Elena, Sikora Martin, Casals Ferran, Giacomo P. Comi, Bresolin Nere Tags: Research Article Source Type: research

NeuroMetrix stock sinks on lower revenues
Medical device company NeuroMetrix, Inc. (Nasdaq: NURO) ended Tuesday down 13 percent from Friday’s close after reporting lower revenues and net loss for 2012 compared to 2011. The Waltham company, which has been focused on the neurological complications of diabetes in recent years, took in $7.6 million in revenues for 2012, down 25 percent from its 2011 revenues. In the same time, net loss stayed about the same, at $10 million for the full year. For the three months that ended in December, the…
Source: bizjournals.com Health Care:Biotechnology headlines - February 19, 2013 Category: Biotechnology Authors: Don Seiffert Source Type: research

Flotillins regulate membrane mobility of the dopamine transporter but are not required for its protein kinase C dependent endocytosis
Summary Flotillins were proposed to mediate clathrin‐independent endocytosis, and recently, flotillin‐1 was implicated in the protein kinase C (PKC)‐triggered endocytosis of the dopamine transporter (DAT). Since endocytosis of DAT was previously shown to be clathrin‐mediated, we re‐examined the role of clathrin coat proteins and flotillin in DAT endocytosis using DAT tagged with the hemagglutinin epitope (HA) in the extracellular loop and a quantitative HA antibody uptake assay. Depletion of flotillin‐1, flotillin‐2 or both flotillins together by small interfering RNAs (siRNAs) did not inhibit PKC‐dependent...
Source: Traffic - February 19, 2013 Category: Research Authors: Tatiana Sorkina, John Caltagarone, Alexander Sorkin Tags: Original Article Source Type: research

Retinal implant restores partial sight to blind people
Some previously blind patients fitted with retinal implant could read signs, tell the time and distinguish white wine from redBlind people have described smiles on friendly faces, the food on their plates, and household objects from telephones to dustbins, after surgeons fitted them with electronic chips to partially restore their vision.Results from the first eight patients to enrol in a clinical trial of the retinal implants show that five found the chips improved their eyesight enough to be useful in everyday life.All those involved – men and women aged 35 to 62 – had lost their sight to retinitis pigmentosa, a here...
Source: Guardian Unlimited Science - February 19, 2013 Category: Science Authors: Ian Sample Tags: World news Health guardian.co.uk Medical research Human biology Society Neuroscience UK news Disability Blindness and visual impairment Source Type: news

Light-sensing chip replaces damaged cells in eye – video
An electronic chip measuring 3mm square has been implanted behind the retina of patients left blind by retinitis pigmentosa
Source: Guardian Unlimited Science - February 19, 2013 Category: Science Tags: Biology Health guardian.co.uk Medical research Human biology Society Neuroscience Blindness and visual impairment Editorial Source Type: news

Tysabri for children with MS
A study of 20 children with MS has found that natalizumab (Tysabri) had a big effect on reducing relapses (from an average of 3.77 a year to 0.4). Half of participants experienced side effects (including weakness and anaemia) and two developed neutralising antibodies that stopped the drug working. MedPage Today Natalizumab (Tysabri) - A to Z of MS
Source: Multiple Sclerosis Trust - February 19, 2013 Category: Neurology Source Type: news

Anteroposterior perfusion heterogeneity in human hippocampus measured by arterial spin labeling MRI
Measurements of blood flow in the human hippocampus are complicated by its relatively small size, unusual anatomy and patterns of blood supply. Only a handful of arterial spin labeling (ASL) MRI articles have reported regional cerebral blood flow (rCBF) values for the human hippocampus. Numerous reports have found heterogeneity in a number of other physiological and biochemical parameters along the longitudinal hippocampal axis. There is, however, only one ASL study of perfusion properties as a function of anteroposterior location in the hippocampus, reporting that rCBF is lower and the arterial transit time (ATT) is longe...
Source: NMR in Biomedicine - February 19, 2013 Category: Radiology Authors: Xiufeng Li, Subhendra N. Sarkar, David E. Purdy, Jeffrey S. Spence, Robert W. Haley, Richard W. Briggs Tags: Research article Source Type: research

Maternal Obesity May Alter Fetal Brain (CME/CE)
SAN FRANCISCO (MedPage Today) -- Having an obese mother may change early fetal brain development, a gene expression analysis suggested.
Source: MedPage Today Endocrinology - February 19, 2013 Category: Endocrinology Source Type: news

Cutaneous Neoplasms Showing EWSR1 Rearrangement
Rearrangements of the EWSR1 gene are found in an increasing number of human neoplasms, including several tumors that can involve the skin: Ewing sarcoma/primitive neuroectodermal tumor, angiomatoid (malignant) fibrous histiocytoma, myoepithelioma of soft tissue, and clear cell sarcoma. Although these tumors share this common genetic link, they have very different clinical features, morphology, immunophenotype, and sometimes fusion gene partners; these will be the subjects of this review.
Source: Advances in Anatomic Pathology - February 19, 2013 Category: Pathology Tags: Review Articles Source Type: research

Tysabri May Be Option for Kids with MS (CME/CE)
(MedPage Today) -- Off-label treatment with natalizumab (Tysabri) for 20 children with severe multiple sclerosis reduced relapses and brain lesions seen on MRI scans, a retrospective analysis found.
Source: MedPage Today Pediatrics - February 19, 2013 Category: Pediatrics Source Type: news

Country diary: Wenlock Edge: Communities of voices – the link between birdsong and spoken language
Wenlock Edge: Neurobiologists have discovered gene products for speech in the human brain which correspond to similar molecules in the brains of birds that learn their songsOn the brightest day so far in this dirty dog of a winter, a cold easterly raked treetops, water dripped from the mossy rock face of Knowle quarry and a few birds called above the whoosh of traffic. From the National Trust hide, bird feeders – like magnetic fields – were frenetic with greenfinch, chaffinch, great tits, bluetits, coal tits, marsh tits, nuthatch and robins. Birds flew in quickly, barely having time to tag a seed or two, then beat it b...
Source: Guardian Unlimited Science - February 19, 2013 Category: Science Authors: Paul Evans Tags: The Guardian Birds Rural affairs Neuroscience Features Animals UK news Environment Wildlife Source Type: news

LAST CALL: Risk/Benefit in Duchenne Therapies Survey
This is our last call for participants for the survey. If you have already done the survey, thanks so much! If you haven’t done the survey, or are in the middle of completing it, please do so before 9:00 PM Eastern time on Wednesday, Feb 20th. We are still in need of a few more participants. We especially need parents OR guardians of: Very young children, especially age 4 and under Children who are able to walk some, but who are having a lot of difficulty Adults who have lost the ability to power their own wheelchair Take the treatment priorities survey now.
Source: Parent Project Muscular Dystrophy - February 19, 2013 Category: Neurology Source Type: news

Action Alert: Help Reauthorization from Home
We recognize that not everyone is able to travel to Washington for our Advocacy conference. While our advocates continue to visit offices on Capitol Hill, you can make a difference from home. You are just a couple of clicks away from helping! Many of you already submitted your information for our packet drop off – here is one more simple step you can take to help to solidify your message to Congress. Help make our voice heard this week in Washington... Make a Phone Call and Send an Email PPMD families from across the country need your help urging Senators, Congressmen and/or their staff to co-sponsor the Paul D. ...
Source: Parent Project Muscular Dystrophy - February 19, 2013 Category: Neurology Source Type: news

CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization
In this study, we provide evidence linking CNP/cGMP signaling to microtubule dynamics via the microtubule regulator CRMP2. First, phosphorylation of CRMP2 can be suppressed by cGMP activation in embryonic DRG neurons, and non‐phosphorylated CRMP2 promotes axon branching and growth. In addition, real time analysis of growing microtubule ends indicates a similar correlation of CRMP2 phosphorylation and its activity in promoting microtubule polymerization rates and durations in COS cells and DRG growth cones. Moreover, direct activation of cGMP signaling leads to increased assembly of dynamic microtubules in DRG growth cone...
Source: Journal of Neurobiology - February 19, 2013 Category: Neurology Authors: Caihong Xia, Minh Nguyen, Amy K. Garrison, Zhen Zhao, Zheng Wang, Calum Sutherland, Le Ma Tags: Research Article Source Type: research

Cardiovascular stress reactivity tasks successfully predict the hypotensive response of isometric handgrip training in hypertensives
This study aimed to determine whether: (a) isometric handgrip (IHG) training lowers resting blood pressure (BP), (b) cardiovascular reactivity to a serial subtraction (SST), IHG (IHGT), and cold pressor (CPT) task predicts this hypotensive response, and (c) cardiovascular reactivity is attenuated posttraining. Resting BP and cardiovascular reactivity to a SST, IHGT, and CPT were measured in 24 hypertensives (51–74 years) before and after 10 weeks of IHG training (n = 12) or control (n = 12). IHG training lowered resting BP (Δ8/5 mmHg), whereby the decrease in systolic BP was correlated to pretraining systolic ...
Source: Psychophysiology - February 19, 2013 Category: Neurology Authors: Mark B. Badrov, Sean Horton, Philip J. Millar, Cheri L. McGowan Tags: Original Article Source Type: research

Testican‐3: A brain‐specific proteoglycan member of the BM‐40/SPARC/osteonectin family
Abstract The testicans are a three –member family of secreted proteoglycans structurally related to the BM‐40/SPARC/osteonectin family of extracellular calcium‐binding proteins. In vitro studies have indicated that testicans are involved in the regulation of extracellular protease cascades and in neuronal function. Here we describe the biochemical characterization and tissue distribution of mouse testican‐3 as well as the inactivation of the corresponding gene. The expression of testican‐3 in adult mice is restricted to the brain where it is located diffusely within the extracellular matrix as well as associated ...
Source: Journal of Neurochemistry - February 19, 2013 Category: Neurology Authors: Ursula Hartmann, Hanni Hülsmann, Judith Seul, Sandra Röll, Heven Midani, Isabelle Breloy, Daniel Hechler, Regina Müller, Mats Paulsson Tags: Original Article Source Type: research

Integrated psychological therapy: effectiveness in schizophrenia inpatient settings related to patients' age.
CONCLUSIONS: These results support evidence for the efficacy of IPT independent of age. Results further indicate the need of goal-oriented specific psychological interventions for middle-aged and older patients with schizophrenia. PMID: 23395190 [PubMed - in process]
Source: Am J Geriatr Psychia... - February 19, 2013 Category: Geriatrics Authors: Mueller DR, Schmidt SJ, Roder V Tags: Am J Geriatr Psychiatry Source Type: research

Cognition and Amyloid Load in Alzheimer Disease Imaged With Florbetapir F 18(AV-45) Positron Emission Tomography.
CONCLUSION: [(18)F]-AV-45 SUVR in several brain regions was associated with worse global cognitive performance particularly in HC, suggesting its potential as a marker of preclinical AD. PMID: 23395194 [PubMed - in process]
Source: Am J Geriatr Psychia... - February 19, 2013 Category: Geriatrics Authors: Rosenberg PB, Wong DF, Edell SL, Ross JS, Joshi AD, Brašić JR, Zhou Y, Raymont V, Kumar A, Ravert HT, Dannals RF, Pontecorvo MJ, Skovronsky DM, Lyketsos CG Tags: Am J Geriatr Psychiatry Source Type: research

Neuropsychological predictors of dementia in late-life major depressive disorder.
CONCLUSIONS: Depressed older adults with cognitive deficits in the domains of memory and executive functions during acute depression are at higher risk for developing dementia. Some cases of late-life depression may reflect a prodrome of dementia in which clinical manifestation of mood changes may co-occur with emerging cognitive deficits. PMID: 23395197 [PubMed - in process]
Source: Am J Geriatr Psychia... - February 19, 2013 Category: Geriatrics Authors: Potter GG, Wagner HR, Burke JR, Plassman BL, Welsh-Bohmer KA, Steffens DC Tags: Am J Geriatr Psychiatry Source Type: research

A new cultural adaptation of the University of Pennsylvania Smell Identification Test
CONCLUSION: The changes made in the new cultural adaptation of the Portuguese version of the University of Pennsylvania Smell Identification Test were effective in increasing the average test scores of the participants. Overall, the female subjects outperformed the male subjects on the test.
Source: Clinics - February 19, 2013 Category: Journals (General) Source Type: research

'At last, someone can hear me': First words of man left brain damaged after brutal attack who can 'speak' for first time in 20 years thanks to an iPad
Kevin Beverley, 55, from Barnsley, South Yorkshire, could only make himself understood through grunts until he discovered an iPad application that 'speaks' for him.
Source: the Mail online | Health - February 19, 2013 Category: Consumer Health News Source Type: news

Brain Lesions Can Predict Alzheimer's Diagnosis
Damage to small blood vessels in the brain could be a secondary risk factor leading to Alzheimer's Disease, a new study in JAMA Neurology suggests. A part of this blood vessel damage is known as white matter hyperintensities, seen in the brains of Alzheimer's patients and appearing to increase the risk for the disease, making it a secondary factor. Experts believe the primary factor of Alzheimer's development is the accumulation of beta amyloid plaques in the brain...
Source: Health News from Medical News Today - February 19, 2013 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news

Fluorescent Tracer ‘Lights Up’ Brain Tumor for Surgery
A bright pink glow showed the precise pathway a glioma took to spread through the brain
Source: The Doctors Lounge - Oncology - February 19, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Neurology, Oncology, Research, Surgery, News, Source Type: news

Step into the Twilight Zone: Day 18, Cuddle Cafes and the Dangers of Dozing
[caption id="attachment_3717" align="alignleft" width="300" caption="Credit: Harry Whittier Frees, Wikimedia Commons"] [/caption] [More]
Source: Scientific American - Official RSS Feed - February 19, 2013 Category: Science Tags: Health,Space,More Science,Mind & Brain Source Type: research

The science and clinical translation of remote postconditioning
The treatment of reperfusion injury requires measures beyond timely reperfusion. Conventional postconditioning (PostC) of ischemic tissues offers a strategy to reduce reperfusion injury, but its adoption is challenged by requiring access and imposing additional ischemia to the ischemic organ. Generating protective signals by PostC in a tissue remote from the target organ such as the limb, i.e. remote PostC (rPostC), may present an alternative approach to exerting endogenous tissue protection. Because rPostC is only recently reported, the fundamental biology of rPostC is not well understood, and studies to date are largely ...
Source: Journal of Cardiovascular Medicine - February 19, 2013 Category: Cardiology Tags: Guest Editor: Gerd Heusch Source Type: research