Neuroscience
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Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation
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We investigated the effects of disease progression on brain regional neurochemistry in a mutant mouse model of familial amyotrophic lateral sclerosis (FALS; the G93A model) using in vivo and in vitro magnetic resonance spectroscopy (MRS). There were numerous changes in the brain spectra that were brain region dependent. At early time points starting around 80 days of age there were increases in brain glutamate. At later time points there were more extensive changes including decreased N-acetyl aspartate and glutamate and increased glutamine, taurine and myo-inositol. The effects of the disease were most severe in spinal co...
Source: European Journal of Neuroscience - November 21, 2009 Category: Neuroscience Authors: Ji-Kyung Choi, Ekkehard Küstermann, Alpaslan Dedeoglu, Bruce G. Jenkins Source Type: journals
From the editorsEmail this article to a colleague.
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Nature Reviews Neuroscience 10, 831 (2009). doi:10.1038/nrn2772
The fortieth annual Society for Neuroscience meeting this year welcomed over 30,000 delegates and was again a resounding success, with talks and posters pointing to important developments and approaches in neuroscience, several of which will feature in forthcoming issues of Nature Reviews Neuroscience.MicroRNAs (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 20, 2009 Category: Neuroscience Tags: From The Editors Source Type: journals
In BriefEmail this article to a colleague.
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Nature Reviews Neuroscience 10, 835 (2009). doi:10.1038/nrn2771
Place cells (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 20, 2009 Category: Neuroscience Tags: Research Highlight Source Type: journals
In BriefEmail this article to a colleague.
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Nature Reviews Neuroscience 10, 834 (2009). doi:10.1038/nrn2770
Pain (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 20, 2009 Category: Neuroscience Tags: Research Highlight Source Type: journals
Development: Initiation of a new connectionEmail this article to a colleague.
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Nature Reviews Neuroscience 10, 833 (2009). doi:10.1038/nrn2769
Author: Claudia Wiedemann
The molecular mechanisms that regulate synapse formation are not well understood. Eroglu et al. show that thrombospondin (TSP) binding to the neuronal α2δ-1 receptor initiates the formation of new synapses in vitro and in vivo and that the anti-epileptic and analgesic drug (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 20, 2009 Category: Neuroscience Authors: Claudia Wiedemann Tags: Research Highlight Source Type: journals
Epigenetics: Stressed for lifeEmail this article to a colleague.
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Nature Reviews Neuroscience 10, 836 (2009). doi:10.1038/nrn2768
Author: Leonie Welberg
Early-life stress (ELS) has long-lasting effects on the brain, and the epigenetic mechanisms underlying them are beginning to be unravelled. Murgatroyd et al. now show that methyl-CpG-binding protein 2 (MeCP2)-mediated regulation of arginine vasopressin (Avp) gene expression in parvocellular hypothalamus (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 20, 2009 Category: Neuroscience Authors: Leonie Welberg Tags: Research Highlight Source Type: journals
Neurogenesis: A mother–daughter relationshipEmail this article to a colleague.
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Neurogenesis: A mother–daughter relationship
Nature Reviews Neuroscience 10, 833 (2009). doi:10.1038/nrn2767
Author: Katherine Whalley
Radial glia in the ventricular zone (VZ) of the developing cortex divide asymmetrically, producing a self-renewing radial glial cell that remains in the VZ and a cell that differentiates into a neuron or an intermediate progenitor. How these differing fates are determined was unknown; however, (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 20, 2009 Category: Neuroscience Authors: Katherine Whalley Tags: Research Highlight Source Type: journals
Neural coding: Oscillations help to decode spike patternsEmail this article to a colleague.
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Nature Reviews Neuroscience 10, 834 (2009). doi:10.1038/nrn2766
Author: Monica Hoyos Flight
In sensory processing, a neuron's firing rate and the timing of the spikes relative to the stimulus onset together encode information. In reality, however, stimuli are often ongoing, raising the question of what else could provide a reference point for spike timing. Previous studies suggested (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 20, 2009 Category: Neuroscience Authors: Monica Hoyos Flight Tags: Research Highlight Source Type: journals
TrkB signalling pathways in LTP and learningEmail this article to a colleague.
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Nature Reviews Neuroscience 10, 850 (2009). doi:10.1038/nrn2738
Author: Liliana Minichiello
Understanding the mechanisms that underlie learning is one of the most fascinating and central aims of neurobiological research. Hippocampal long-term potentiation (LTP) is widely regarded as a prime candidate for the cellular mechanism of learning. The receptor tyrosine kinase TrkB (also known as NTRK2), known (Source: Nature Reviews Neuroscience)
Source: Nature Reviews Neuroscience - November 20, 2009 Category: Neuroscience Authors: Liliana Minichiello Tags: Review Source Type: journals
Economics, Neuroscience And Hormones WorkshopEmail this article to a colleague.
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A workshop on "Neuroeconomics and Endocrinological Economics," being held Nov. 20 and 21 at UC Davis, will be the first to bring together experts in neuroscience, economics and hormone physiology in one event, according to organizers. Neuroeconomics has emerged as a new field in recent years, as both economists and neuroscientists have used brain scanning technology such as functional magnetic resonance imaging to investigate how people make decisions. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 20, 2009 Category: Neuroscience Tags: Neurology / Neuroscience Source Type: news
Drug Studied As Possible Treatment For Spinal InjuriesEmail this article to a colleague.
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Researchers have shown how an experimental drug might restore the function of nerves damaged in spinal cord injuries by preventing short circuits caused when tiny "potassium channels" in the fibers are exposed. The chemical compound also might be developed as a treatment for multiple sclerosis. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 20, 2009 Category: Neuroscience Tags: Neurology / Neuroscience Source Type: news
Spineology Receives FDA Clearance For Capture™ Facet Screw SystemEmail this article to a colleague.
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Spineology Inc., developer and manufacturer of minimally invasive spinal surgery devices, announced today that it has received FDA clearance for its minimally invasive surgery (MIS) Capture™ Facet Screw System. The Capture System was developed by Spineology in mid-2009 under the direction of Dr. Chet Sutterlin, product development consultant. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 20, 2009 Category: Neuroscience Tags: Neurology / Neuroscience Source Type: news
Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brainEmail this article to a colleague.
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Conclusions:
Results suggest that repeated activation of memory structures facilitates anamnesis and may promote neuronal plasticity in the ageing brain, and that compliance is a key factor in such facilitation as the effect was confined to those who engaged fully with the training. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - November 20, 2009 Category: Neuroscience Authors: Richard RocheSinead MullallyJonathan McNultyJudy HaydenPaul BrennanColin DohertyMary FitzsimonsDeirdre McMackinJulie PrendergastSunita SukumaranMaeve MangaoangIan RobertsonShane O'Mara Source Type: journals
The strength of anticipatory spatial biasing predicts target discrimination at attended locations: a high-density EEG studyEmail this article to a colleague.
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Cueing relevant spatial locations in advance of a visual target results in modulated processing of that target as a consequence of anticipatory attentional deployment, the neural signatures of which remain to be fully elucidated. A set of electrophysiological processes has been established as candidate markers of the invocation and maintenance of attentional bias in humans. These include spatially-selective event-related potential (ERP) components over the lateral parietal (around 200[ndash]300 ms post-cue), frontal (300[ndash]500 ms) and ventral visual (> 500 ms) cortex, as well as oscillatory amplitude changes in the alp...
Source: European Journal of Neuroscience - November 20, 2009 Category: Neuroscience Authors: Simon P. Kelly, Manuel Gomez-Ramirez, John J. Foxe Source Type: journals
Progesterone and allopregnanolone enhance the miniature synaptic release of glycine in the rat hypoglossal nucleusEmail this article to a colleague.
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It is well known that progesterone is synthesised and metabolised within the nervous system, and that one of its metabolites, allopregnanolone, potentiates the activity of GABA receptor anionic channels and modulates GABAergic neurotransmission. Progesterone is now under clinical trial for its neuroprotective properties, but its possible effects on neurotransmission have not yet been fully explored. The present study investigated acute effects of progesterone on the other major type of synaptic inhibition, glycinergic neurotransmission. Spontaneous glycinergic miniature currents were recorded in hypoglossal motoneurons, us...
Source: European Journal of Neuroscience - November 20, 2009 Category: Neuroscience Authors: Dominique Chesnoy-Marchais Source Type: journals
Metabolic Effects Significantly Lower With INVEGA(R) Compared To OlanzapineEmail this article to a colleague.
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New data from a 6-month open label randomised controlled trial show INVEGA® (paliperidone ER) is associated with significantly less metabolic effects compared to oral olanzapine in people with schizophrenia, while demonstrating comparable efficacy.1 The results were presented at the 15th Biennial Winter Workshop in Psychoses in Barcelona, Spain. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 19, 2009 Category: Neuroscience Tags: Schizophrenia Source Type: news
Stanford/Packard Study In Mice Suggests New Down Syndrome TreatmentEmail this article to a colleague.
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At birth, children with Down syndrome aren't developmentally delayed. But as they age, these kids fall behind. Memory deficits inherent in Down syndrome hinder learning, making it hard for the brain to collect experiences needed for normal cognitive development. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 19, 2009 Category: Neuroscience Tags: Pediatrics / Children's Health Source Type: news
Findings That Should Speed The Development Of Drugs For Parkinson's DiseaseEmail this article to a colleague.
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Australian scientists have significantly advanced our understanding of dopamine release from nerve cells, findings that should speed the development of more effective drugs for treating Parkinson's Disease. People with Parkinson's Disease suffer from muscle rigidity, tremor, a slowing of physical movement and, in extreme cases, a loss of physical movement. These primary symptoms are caused by the loss of dopamine producing nerve cells in the brain. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 19, 2009 Category: Neuroscience Tags: Parkinson's Disease Source Type: news
The Protein Srebp2 Drives Cholesterol Formation In Prion-Infected Neuronal Cells Which May Promote Prion-Dependent DiseasesEmail this article to a colleague.
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Prions are causing fatal and infectious diseases of the nervous system, such as the mad cow disease (BSE), scrapie in sheep or Creutzfeldt-Jakob disease in humans. Scientists of Helmholtz Zentrum München and Technische Universität München have now succeeded in elucidating another disease mechanism of prion diseases: The prion-infected cell changes its gene expression and produces increased quantities of cholesterol. Prions need this for their propagation. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 19, 2009 Category: Neuroscience Tags: Neurology / Neuroscience Source Type: news
Abnormalities in brain structure and behavior in GSK-3 mutant miceEmail this article to a colleague.
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Conclusions:
Taken together, our data support a role for the GSK-3alpha gene in CNS functioning and possible involvement in the development of psychiatric disorders. (Source: Molecular Brain)
Source: Molecular Brain - November 19, 2009 Category: Neuroscience Authors: Oksana Kaidanovich-BeilinTatiana LipinaKeizo TakaoMatthijs van EedeSatoko HattoriChristine LaliberteMustafa KhanKenichi OkamotoJohn ChambersPaul FletcherKatrina MacAulayBradley DobleMark HenkelmanTsuyoshi MiyakawaJohn RoderJames Woodgett Source Type: journals
Identifying the control of physically and perceptually evoked sway responses with coincident visual scene velocities and tilt of the base of support.Email this article to a colleague.
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In this study, we have explored whether the impact of visual information on postural reactions is due to the same perceptual mechanisms that produce vection. Pitch motion of the visual field was presented at varying velocities to eight healthy subjects (29.9 +/- 2.8 years) standing quietly on a stationary base of support or receiving a 3 degrees toes-up tilt of the base of support. An infrared motion system recorded markers placed on body segments to record angular displacement of head and ankle and calculate whole body center of mass. Onset of the visual field motion and base of support movement were synchronized in all t...
Source: Experimental Brain Research - November 19, 2009 Category: Neuroscience Authors: Wang Y, Kenyon RV, Keshner EA Tags: Exp Brain Res Source Type: journals
Orexins Excite Neurons of the Rat Cerebellar Nucleus Interpositus Via Orexin 2 Receptors In Vitro.Email this article to a colleague.
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In this study, perfusing slices with orexin A (100 nM-1 muM) or orexin B (100 nM-1 muM) both produced neurons in the rat cerebellar interpositus nucleus (IN) a concentration-dependent excitatory response (96/143, 67.1%). Furthermore, both of the excitations induced by orexin A and B were not blocked by the low-Ca(2+)/high-Mg(2+) medium (n = 8), supporting a direct postsynaptic action of the peptides. Highly selective orexin 1 receptor antagonist SB-334867 did not block the excitatory response of cerebellar IN neurons to orexins (n = 22), but [Ala(11), D-Leu(15)] orexin B, a highly selective orexin 2 receptor (OX(2)R) agoni...
Source: Cerebellum - November 19, 2009 Category: Neuroscience Authors: Yu L, Zhang XY, Zhang J, Zhu JN, Wang JJ Tags: Cerebellum Source Type: journals
Altered Regulation of CD200 Receptor in Monocyte-Derived Macrophages from Individuals with Parkinson's Disease.Email this article to a colleague.
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Microglia are the representative myeloid cells in the brain, and their over-activation plays an important role in the pathogenesis of Parkinson's disease (PD). Microglia activation is believed to be regulated by the CD200-CD200R signaling. As the peripheral counterpart of microglia, monocyte-derived macrophages (MDMs) share the same progenitor and antigen markers, and they have similar biological behaviors and mirror microglial function in the brain. Here, we studied CD200R expression and its regulation in MDMs from 32 PD cases, 27 age-matched old controls, and 28 young controls. We found that the basal CD200R expressi...
Source: Neurochemical Research - November 19, 2009 Category: Neuroscience Authors: Luo XG, Zhang JJ, Zhang CD, Liu R, Zheng L, Wang XJ, Chen SD, Ding JQ Tags: Neurochem Res Source Type: journals
Sex Steroids Inhibit Osmotic Swelling of Retinal Glial Cells.Email this article to a colleague.
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Osmotic swelling of glial cells may contribute to the development of retinal edema. We investigated whether sex steroids inhibit the swelling of glial somata in acutely isolated retinal slices and glial cells of the rat. Superfusion of retinal slices or cells from control animals with a hypoosmolar solution did not induce glial swelling, whereas glial swelling was observed in slices of postischemic and diabetic retinas. Progesterone, testosterone, estriol, and 17ss-estradiol prevented glial swelling with half-maximal effects at approximately 0.3, 0.6, 6, and 20 muM, respectively. The effect of progesterone was apparent...
Source: Neurochemical Research - November 19, 2009 Category: Neuroscience Authors: Neumann F, Wurm A, Linnertz R, Pannicke T, Iandiev I, Wiedemann P, Reichenbach A, Bringmann A Tags: Neurochem Res Source Type: journals
CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcriptionEmail this article to a colleague.
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Conclusions:
Our findings indicate possible mechanisms by which CBP/p300 tissue-specifically acts cooperatively with pCAF and HDAC3 either as a co-activator or co-repressor, respectively, for CLOCK/BMAL1. (Source: Molecular Brain)
Source: Molecular Brain - November 19, 2009 Category: Neuroscience Authors: Hiroshi HosodaKenichi KatoHidenori AsanoMotonori ItoHaruno KatoTaku IwamotoAkinobu SuzukiShoichi MasusigeSatoshi Kida Source Type: journals
Ellipse Technologies, Inc. Receives CE Mark Clearance For The MAGECTM System For The Treatment Of Spinal ScoliosisEmail this article to a colleague.
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Ellipse Technologies, Inc. ("Ellipse") announced today it has received CE Mark (Conformité Européenne) for its MAGECTM Technology for the treatment of spinal deformity. The first application for this technology is for the treatment of spinal scoliosis in young children and teenagers. The CE Mark allows the Company to market the MAGEC System in the European Union and other countries that recognize the CE Mark for commercial distribution purposes. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 18, 2009 Category: Neuroscience Tags: Neurology / Neuroscience Source Type: news
Explanation For Rapid Maturation Of Neurons At Birth Found By Duke ResearchersEmail this article to a colleague.
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At the moment a newborn switches from amniotic fluid to breathing air, another profound shift occurs: nerve cells in the brain convert from hyperexcitability to a calm frame against which outside signals can be detected. "Fetal neurons need hyperexcitability for proper development, because they are moving to the right places (in the brain) and forming the right connections," said Wolfgang Liedtke, M.D., Ph.D. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 18, 2009 Category: Neuroscience Tags: Epilepsy Source Type: news
Monetary Gain And High-risk Tactics Stimulate Activity In The BrainEmail this article to a colleague.
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Monetary gain stimulates activity in the brain. Even the mere possibility of receiving a reward is known to activate an area of the brain called the striatum. A team of Japanese researchers report in the January 2010 issue of Cortex, published by Elsevier, the results of a study in which they measured striatum activation in volunteers performing a monetary task and found high-risk/high-gain options to cause higher levels of activation than more conservative options. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 18, 2009 Category: Neuroscience Tags: Psychology / Psychiatry Source Type: news
Cancer-Fighting Drugs Delivered Right To The TumorEmail this article to a colleague.
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An encapsulation breakthrough by researchers at the Technion-Israel Institute of Technology may enable doctors to deliver anti-cancer drugs directly to tumors over extended periods of time, while preventing the systemic side effects of chemotherapy and other current cancer treatments. The system consists of polymeric microcapsules containing human mesenchymal stem cells (MSCs) engineered to produce proteins that prevent cancer growth. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 18, 2009 Category: Neuroscience Tags: Cancer / Oncology Source Type: news
Proprioceptive localization of the left and right hands.Email this article to a colleague.
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The present study examined the accuracy of proprioceptive localization of the hand using two paradigms. In our proprioceptive estimation paradigm, participants judged the position of a target hand relative to visual references, or their body's midline. Placement of the target hand was active (participants pushed a robot manipulandum along a constrained path) or passive (the robot manipulandum positioned participants' target hand). In our proprioceptive-guided reaching paradigm, participants reached to the unseen location of a hand; both the left and right hands served as the target hand and the reaching hand. In both p...
Source: Experimental Brain Research - November 18, 2009 Category: Neuroscience Authors: Jones SA, Cressman EK, Henriques DY Tags: Exp Brain Res Source Type: journals
Evidence for limb-independent control of locomotor trajectory.Email this article to a colleague.
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After stepping in place on a rotating treadmill, individuals exhibit involuntary turning in the direction opposite treadmill rotation when stepping in place on a stationary surface without vision. This response is called podokinetic after-rotation (PKAR). It remains unclear where the control center for PKAR is located and whether separate, independent podokinetic control centers exist for each lower limb. To better understand neural mechanisms underlying locomotor trajectory adaptation, this study asked whether PKAR transfers between lower limbs. Thirteen healthy adults underwent separate 15-min sessions where one (tra...
Source: Experimental Brain Research - November 18, 2009 Category: Neuroscience Authors: McNeely ME, Earhart GM Tags: Exp Brain Res Source Type: journals
Presenilin transgenic mice as models of Alzheimer's disease.Email this article to a colleague.
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Mutations in presenilin-1 (PS1) and presenilin-2 (PS2) cause familial Alzheimer's disease (FAD). Presenilins influence multiple molecular pathways and are best known for their role in the gamma-secretase cleavage of type I transmembrane proteins including the amyloid precursor protein (APP). PS1 and PS2 FAD mutant transgenic mice have been generated using a variety of promoters. PS1-associated FAD mutations have also been knocked into the endogenous mouse gene. PS FAD mutant mice consistently show elevations of Abeta42 with little if any effect on Abeta40. When crossed with plaque forming APP FAD mutant lines, the PS1 ...
Source: Brain Structure and Function - November 18, 2009 Category: Neuroscience Authors: Elder GA, Gama Sosa MA, De Gasperi R, Dickstein DL, Hof PR Tags: Brain Struct Funct Source Type: journals
Strain Difference in the Up-Regulation of FGF-2 Protein Following a Neurotoxic Lesion of the Nigrostriatal Pathway.Email this article to a colleague.
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In this study we examined protein content of basic fibroblast growth factor (FGF-2) in tissue samples taken from the ventral midbrain and striatum at two different time points following a neurotoxic lesion of the nigrostriatal pathway in two different rat strains, the outbred Sprague-Dawley (SD) and inbred F344 x Brown Norway F1 hybrid (F344BNF(1)). Despite both rat strains having comparable lesions of the nigrostriatal pathway, we observed a difference in the temporal up-regulation of FGF-2 in ventral midbrain samples taken from the side ipsilateral to the lesion. Basic FGF was significantly up-regulated in ventral midbra...
Source: Neurochemical Research - November 18, 2009 Category: Neuroscience Authors: Yurek DM, Fletcher AM, Peters LE, Cass WA Tags: Neurochem Res Source Type: journals
Cardioactive Protein-Hormonal Complexes of Brain and Heart.Email this article to a colleague.
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New cardioactive protein-hormone complexes (PHC) are identified in magnocellular nuclei of hypothalamus. It was proved that they are specific for nervous tissues and are involved in the regulation of metabolic processes of brain and visceral organs, including the heart. PHC dissociate into high-molecular forms which are new specific glycoproteins and the low-molecular cardioactive neurohormones. Results of our own studies on the functional activities of PHC as well as cardioactive peptides in the precardiac and auricular regions of the heart with respect to the parameters of haemostasis system are reviewed.
PMID: 1...
Source: Neurochemical Research - November 18, 2009 Category: Neuroscience Authors: Srapionyan RM, Galoyan AA Tags: Neurochem Res Source Type: journals
Wavelet Analysis as a Tool for Investigating Movement-Related Cortical Oscillations in EEG-fMRI Coregistration.Email this article to a colleague.
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In this study we used EEG-fMRI to determine the possible correlation between topographical movement-related EEG changes in brain oscillatory activity recorded from EEG electrodes over the scalp and fMRI cortical responses in motor areas during finger movement. Thirty-two channels of EEG were recorded in 12 subjects during eyes-closed condition inside a three T magnetic resonance (MR) scanner using an MR-compatible EEG recording system. Off-line MRI artifact subtraction software was applied to obtain continuous EEG data during fMRI acquisition. For EEG data analysis we used a time-frequency approach to measure time by varyi...
Source: Brain Topography - November 18, 2009 Category: Neuroscience Authors: Storti SF, Formaggio E, Beltramello A, Fiaschi A, Manganotti P Tags: Brain Topogr Source Type: journals
The choroid plexus response to a repeated peripheral inflammatory stimulusEmail this article to a colleague.
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Conclusions:
These observations contribute to a better understanding of the brain response to peripheral inflammation and pave the way to study their impact on the progression of several disorders of the central nervous system in which inflammation is known to be implicated. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - November 18, 2009 Category: Neuroscience Authors: Fernanda MarquesJoao SousaGiovanni CoppolaDaniel GeschwindNuno SousaJoana PalhaMargarida Correia-Neves Source Type: journals
Sustainable effects on suicidality were found for the Nuremberg alliance against depressionEmail this article to a colleague.
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Abstract During an intense four-level community-based intervention program conducted in Nuremberg (490,000 inhabitants) in 2001 and
2002 [Nuremberg Alliance Against Depression (NAD)], the number of suicidal acts (main outcome completed + attempted suicides)
had dropped significantly (−21.7%), a significant effect compared with the baseline year and the control region (Wuerzburg,
about 290,000 inhabitants). To assess the sustainability of the intervention effects the number of suicidal acts was assessed
in the follow-up year (2003), after the termination of the 2-year intervention. Also, in the fo...
Source: European Archives of Psychiatry and Clinical Neuroscience - November 17, 2009 Category: Neuroscience Tags: European Archives of Psychiatry and Clinical Neuroscience Source Type: journals
Announced reward counteracts the effects of chronic social stress on anticipatory behavior and hippocampal synaptic plasticity in rats.Email this article to a colleague.
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In conclusion, announced short-term enriched housing has a high and long-lasting counteracting efficacy on stress-induced alterations of hippocampal synaptic plasticity. This information is important for counteracting the consequences of chronic stress in both human and captive rats.
PMID: 19921157 [PubMed - as supplied by publisher] (Source: Experimental Brain Research)
Source: Experimental Brain Research - November 17, 2009 Category: Neuroscience Authors: Kamal A, Van der Harst JE, Kapteijn CM, Baars AJ, Spruijt BM, Ramakers GM Tags: Exp Brain Res Source Type: journals
Prospects for Clinical Applications of Transcranial Magnetic Stimulation and Real-Time EEG in Epilepsy.Email this article to a colleague.
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Recent advances in methods for transcranial magnetic stimulation (TMS) enable its coupling to real-time EEG (TMS-EEG). Although TMS-EEG is applied largely in neurophysiology research, there are prospects for its use in clinical TMS practice, particularly in epilepsy where EEG is already in wide use, and where TMS is emerging as a diagnostic and therapeutic tool. In diagnostic applications, TMS-EEG may provide a useful measure of cortical excitability at baseline or after antiepileptic treatment. For therapeutic purposes, TMS-EEG may be of use in selection of appropriate TMS strength outside of the motor cortex where th...
Source: Brain Topography - November 17, 2009 Category: Neuroscience Authors: Rotenberg A Tags: Brain Topogr Source Type: journals
ContentsEmail this article to a colleague.
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(Source: Neurobiology of Aging)
Source: Neurobiology of Aging - November 16, 2009 Category: Neuroscience Source Type: journals
Erratum to “TNFR-associated factor-2 (TRAF-2) in Alzheimer’s disease” [Culpan et al. (Neurobiol Aging 2009 July;30(7):1052-60)]Email this article to a colleague.
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In the article “TNFR-associated factor-2 (TRAF-2) in Alzheimer’s disease” by Culpan et al. (Neurobiol Aging 2009 July;30(7):1052-60), the 9th author’s name should be David Craig. (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - November 16, 2009 Category: Neuroscience Authors: Doris Culpan, Dougal Cram, Kate Chalmers, Abigail Cornish, Laura Palmer, Jennifer Palmer, Anthony Hughes, Peter Passmore, David Craig, Gordon K. Wilcock, Patrick G. Kehoe, Seth Love Source Type: journals
Editorial Advisory BoardEmail this article to a colleague.
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(Source: Neurobiology of Aging)
Source: Neurobiology of Aging - November 16, 2009 Category: Neuroscience Source Type: journals
Exploring Cortical Attentional System by Using fMRI during a Continuous Perfomance TestEmail this article to a colleague.
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Functional magnetic resonance imaging (fMRI) was performed in eight healthy subjects to identify the localization, magnitude, and volume extent of activation in brain regions that are involved in blood oxygen level-dependent (BOLD) response during the performance of Conners' Continuous Performance Test (CPT). An extensive brain network was activated during the task including frontal, temporal, and occipital cortical areas and left cerebellum. The more activated cluster in terms of volume extent and magnitude was located in the right anterior cingulate cortex (ACC). Analyzing the dynamic trend of the activation in the i...
Source: Computational Intelligence and Neuroscience - November 16, 2009 Category: Neuroscience Source Type: journals
Apogenix Receives Orphan Drug Designation For APG101 In The US And Positive Opinion On Orphan Product Designation In EuropeEmail this article to a colleague.
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Apogenix GmbH, a biopharmaceutical company developing novel drugs for malignant and inflammatory diseases, announced that the European Medicines Agency adopted a positive opinion on orphan medicinal product designation for the company's lead candidate APG101 for the treatment of Glioblastoma multifome (GBM), and that it has already been granted orphan drug status in the US by the US Food and Drug Administration (FDA). (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 16, 2009 Category: Neuroscience Tags: Neurology / Neuroscience Source Type: news
Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilitiesEmail this article to a colleague.
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Conclusion:
We found that PEA-15 null mice have spatial learning disabilities that are similar to those of mice where ERK or RSK2 function is impaired. We suggest PEA-15 may be an essential regulator of ERK-dependent spatial learning. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - November 16, 2009 Category: Neuroscience Authors: Joe RamosDavid TownsendDawn PiarulliStefan KolataKenneth LightGregory HaleLouis Matzel Source Type: journals
Physicians Heal Bridge To Nowhere; Iraqi Girl With Rare Neuromuscular Disorder Has New HopeEmail this article to a colleague.
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Plagued by a growing weakness that left her unable to walk, talk and even take a normal breath, 11-year-old Iraqi Aram Ali was a shell of the bright little girl she used to be. No one could figure out what was wrong. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 15, 2009 Category: Neuroscience Tags: Neurology / Neuroscience Source Type: news
Hospital For Special Surgery Establishes A Comprehensive Spine Care InstituteEmail this article to a colleague.
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Hospital for Special Surgery announced the establishment of one of the most comprehensive centers of excellence in the country for the treatment of all nonoperative and operative spine disorders. The newly formed Spine Care Institute brings together a multidisciplinary team of experts in an academic setting to ensure that every need is met for a patient with a spine condition. Back pain is a widespread problem affecting 8 out of 10 people in the U.S. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - November 15, 2009 Category: Neuroscience Tags: Neurology / Neuroscience Source Type: news
Fixation disengagement enhances peripheral perceptual processing: evidence for a perceptual gap effect.Email this article to a colleague.
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Temporal gaps between the offset of a central fixation stimulus and the onset of an eccentric target typically reduce saccade latencies (saccadic gap effect). Here, we test whether temporal gaps also affect perceptual performance in peripheral vision. In Experiment 1, subjects executed saccades to briefly presented peripheral target letters and reported letter identity afterwards. A central fixation stimulus either remained visible throughout the trial (overlap) or disappeared 200 ms before letter onset (gap). Experiment 2 tested perceptual performance without saccade execution, whereas Experiment 3 tested saccade exec...
Source: Experimental Brain Research - November 15, 2009 Category: Neuroscience Authors: Huestegge L, Koch I Tags: Exp Brain Res Source Type: journals
Kinematic analysis of the human wrist during pointing tasks.Email this article to a colleague.
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In this work, we tested the hypothesis that intrinsic kinematic constraints such as Donders' law are adopted by the brain to solve the redundancy in pointing at targets with the wrist. Ten healthy subjects were asked to point at visual targets displayed on a monitor with the three dof of the wrist. Three-dimensional rotation vectors were derived from the orientation of the wrist acquired during the execution of the motor task and numerically fitted to a quadratic surface to test Donders' law. The thickness of the Donders' surfaces, i.e., the deviation from the best fitting surface, ranged between 1 degrees and 2 degree...
Source: Experimental Brain Research - November 15, 2009 Category: Neuroscience Authors: Campolo D, Formica D, Guglielmelli E, Keller F Tags: Exp Brain Res Source Type: journals
