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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 33.

Erratum to: Phase II dose–response study of abatacept in Japanese patients with active rheumatoid arthritis with an inadequate response to methotrexate
Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s10165-012-0798-3Authors Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 JapanTsukasa Matsubara, Department of Orthopedics, Matsubara Mayflower Hospital, 944-25 Fujita, Kato, Hyogo 673-1462, JapanTaisuke Nitobe, Department of Orthopedics, Seihoku Chuoh Hospital, 41 Nunoyacho, Goshogawara, Aomori 037-0053, JapanEiichi Suematsu, Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama,...
Source: Modern Rheumatology - November 19, 2012 Category: Rheumatology Tags: Modern Rheumatology Source Type: research

Minimally invasive plate osteosynthesis of distal tibial fracture using a posterolateral approach: a cadaveric study and preliminary report
Conclusion  Based on the results of our study, it seems that using the MIPO technique through a posterolateral approach should be a reasonable and safe treatment option for distal tibial fractures, especially when the anterior soft tissue is compromised. However, studies with a higher level of evidence should be done in more patients to confirm the clinical safety of using this technique. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00264-012-1712-5Authors Apipop Kritsaneephaiboon, Department of Orthopaedic Surgery and Physical Medicine, Faculty of Medicine, Prince of Song...
Source: International Orthopaedics - November 19, 2012 Category: Orthopaedics Tags: International Orthopaedics Source Type: research

Cartilage repair of the knee with Hyalograft C:® Magnetic Resonance Imaging assessment of the glycosaminoglycan content at midterm
Conclusions  The study demonstrated stable glycosaminoglycan content of the repair tissue after MACT at midterm. Content Type Journal ArticleCategory Original PaperPages 1-5DOI 10.1007/s00264-012-1700-9Authors Martin O. Brix, Department of Orthopedics, Medical University of Vienna, Vienna, AustriaDavid Stelzeneder, Department of Orthopedics, Medical University of Vienna, Vienna, AustriaSiegfried Trattnig, Department of Radiology, MR Center of Excellence, Medical University of Vienna, Vienna, AustriaReinhard Windhager, Department of Orthopedics, Medical University of Vienna, Vienna, AustriaStephan E. Doma...
Source: International Orthopaedics - November 19, 2012 Category: Orthopaedics Tags: International Orthopaedics Source Type: research

Editorial
Content Type Journal ArticleCategory EditorialPages 1-1DOI 10.1007/s00068-012-0235-5Authors P. M. Rommens, Direktor Klinik Und Poliklinik für Unfallchirurgie Zentrum für Muskuloskeletale Chirurgie, Langenbeckstraße 1, 55131 Mainz, GermanyL. P. Müller, Klinik Und Poliklinik für Orthopädie und Unfallchirurgie Universitätsklinikum Köln, Kerpener Straße 62, 50937 Köln, Germany Journal European Journal of Trauma and Emergency SurgeryOnline ISSN 1863-9941Print ISSN 1863-9933
Source: European Journal of Trauma and Emergency Surgery - November 19, 2012 Category: Surgery Tags: European Journal of Trauma and Emergency Surgery Source Type: research

Post-traumatic high thoracic angular kyphosis: posterior approach with correction and fusion in two steps
Content Type Journal ArticleCategory Open Operating Theatre (OOT)Pages 1-3DOI 10.1007/s00586-012-2567-6Authors Marco Brayda-Bruno, IRCCS Istituto Ortopedico Galeazzi, Milan, ItalyAndrea Luca, IRCCS Istituto Ortopedico Galeazzi, Milan, ItalyAlessio Lovi, IRCCS Istituto Ortopedico Galeazzi, Milan, ItalyMarco Zambotti, IRCCS Istituto Ortopedico Galeazzi, Milan, ItalyAldo Sinigaglia, IRCCS Istituto Ortopedico Galeazzi, Milan, ItalyClaudio Lamartina, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy Journal European Spine JournalOnline ISSN 1432-0932Print ISSN 0940-6719
Source: European Spine Journal - November 19, 2012 Category: Orthopaedics Tags: European Spine Journal Source Type: research

Lumbar hemivertebra resection by posterior approach for congenital scoliosis
Content Type Journal ArticleCategory Open Operating Theatre (OOT)Pages 1-3DOI 10.1007/s00586-012-2569-4Authors Ibrahim Obeid, Bordeaux University Hospital, Bordeaux, FranceAnouar Bourghli, Bordeaux University Hospital, Bordeaux, FranceJean-Marc Vital, Bordeaux University Hospital, Bordeaux, France Journal European Spine JournalOnline ISSN 1432-0932Print ISSN 0940-6719
Source: European Spine Journal - November 19, 2012 Category: Orthopaedics Tags: European Spine Journal Source Type: research

Cervical osteotomy in Ankylosing Spondylitis
Content Type Journal ArticleCategory Open Operating Theatre (OOT)Pages 1-5DOI 10.1007/s00586-012-2587-2Authors S. M. H. Mehdian, Centre for Spinal Studies and Surgery, Queen’s Medical Centre, Nottingham, UKB. Boreham, Centre for Spinal Studies and Surgery, Queen’s Medical Centre, Nottingham, UKT. Hammett, Centre for Spinal Studies and Surgery, Queen’s Medical Centre, Nottingham, UK Journal European Spine JournalOnline ISSN 1432-0932Print ISSN 0940-6719
Source: European Spine Journal - November 19, 2012 Category: Orthopaedics Tags: European Spine Journal Source Type: research

Exostose solitaire géante de la fibula : à propos d’une cause rare de compression du nerf tibial
Résumé  Les exostoses ostéogéniques ou ostéochondromes sont les tumeurs bénignes les plus fréquentes de l’os. Elles se produisent au cours de la période de croissance et sont rarement responsables de complications vasculaires ou nerveuses. Nous rapportons le cas d’un jeune patient de 24 ans, qui a consulté pour une tuméfaction au niveau de son mollet gauche avec des douleurs et des paresthésies au niveau du territoire du nerf tibial. La radiographie a montré une tumeur osseuse exubérante au niveau du tiers supérieur de la fibula. L’angioscanner a permis d’objectiver la compression sur le...
Source: Medecine et Chirurgie du Pied - November 19, 2012 Category: Podiatry Tags: Médecine et Chirurgie du Pied Source Type: research

Determinants of anterior knee pain following total knee replacement: a systematic review
Conclusions  No single variable is likely to explain the differences in the reported rates of AKP, although variables leading to abnormal patellofemoral joint loading appear to be of special significance. Level of evidence  III. Content Type Journal ArticleCategory KneePages 1-22DOI 10.1007/s00167-012-2294-xAuthors Hans-Peter W. van Jonbergen, Department of Orthopedic Surgery, Deventer Hospital, PO Box 5001, 7400 GC Deventer, The NetherlandsJoost M. Reuver, Department of Orthopedic Surgery, Deventer Hospital, PO Box 5001, 7400 GC Deventer, The NetherlandsEduard L. Mutsaerts, Departmen...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - November 19, 2012 Category: Orthopaedics Tags: Knee Surgery, Sports Traumatology, Arthroscopy Source Type: research

Meniscectomy leads to early changes in the mineralization distribution of subchondral bone plate
Conclusions  In conclusion, the results of this study contribute to the concept of early involvement of the SBP in the development of OA. The hypothesis that changes in the SBP occur simultaneously to cartilage damage was confirmed. Content Type Journal ArticleCategory KneePages 1-8DOI 10.1007/s00167-012-2297-7Authors Hermann Anetzberger, Orthopädische Gemeinschaftspraxis am OEZ, Hanauerstr. 65, 80993 Munich, GermanyAlexandra Mayer, Klinikum Bogenhausen, Abteilung Physikalische Medizin und Frührehabilitation, Englschalkingerstrasse 77, 81925 Munich, GermanyChristian Glaser, Department of Radiology, ...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - November 19, 2012 Category: Orthopaedics Tags: Knee Surgery, Sports Traumatology, Arthroscopy Source Type: research

Tibial avulsion fracture of the posterior root of the medial meniscus in children
Abstract  Few reports have described avulsion fractures of the posterior root of the medial meniscus in skeletally immature patients. This lesion should not be overlooked as it damages the load absorptive (distributive) function of the meniscus, increasing the risk of cartilage degeneration. Two cases of displaced avulsion fractures of the posterior root of the medial meniscus in children are presented along with a concise report of the literature regarding avulsion fractures of the posterior root of the medial meniscus. Both avulsions were reattached arthroscopically by trans-tibial pull-out sutures with a g...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - November 19, 2012 Category: Orthopaedics Tags: Knee Surgery, Sports Traumatology, Arthroscopy Source Type: research

Outcome after severe brain trauma associated with epidural hematoma
Abstract Objective  The aim of this study was to identify factors contributing to outcomes after severe traumatic brain injury (TBI) associated with epidural hematoma (EDH). Methods  Between 02/2002 and 4/2010 17 Austrian centers prospectively enrolled 863 patients with moderate and severe TBI into observational studies. Data on accident, treatment, and outcomes were collected. Data sets from patients who had severe TBI (=Glasgow Coma Scale score <9) and EDH were selected. Six-month outcomes were classified as “favorable” if Glasgow Outcome Scale (GOS) scores were 5 or 4, and were c...
Source: Archives of Orthopaedic and Trauma Surgery - November 19, 2012 Category: Orthopaedics Tags: Archives of Orthopaedic and Trauma Surgery Source Type: research

Valgus osteotomy in combination with dynamic hip screw fixation for fibrous dysplasia with shepherd’s crook deformity
Conclusion  Our results demonstrate that valgus osteotomy in combination with DHS internal fixation is an easy and effective method for the treatment of fibrous dysplasia with shepherd’s crook deformity. It can restore the neck-shaft angle and re-establish the mechanical alignment of the femur to improve function. Content Type Journal ArticleCategory Orthopaedic SurgeryPages 1-6DOI 10.1007/s00402-012-1633-1Authors Weixu Li, Department of Orthopaedics, the Second Affiliated Hospital, Medical College of Zhejiang University, No. 88, Jiefang Road, Hangzhou, 310009 ChinaXin Huang, Department of Orthopae...
Source: Archives of Orthopaedic and Trauma Surgery - November 19, 2012 Category: Orthopaedics Tags: Archives of Orthopaedic and Trauma Surgery Source Type: research

Suture anchor tenodesis in repair of distal Achilles tendon injuries
Conclusions  There were no visually altered gait or problems in daily life. Suture anchor tenodesis technique of distal Achilles tendon avulsions was successful in achieving durable osteotendinous repairs. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00590-012-1129-2Authors Önder Kiliçoğlu, Department of Orthopedics and Traumatology, İstanbul Faculty of Medicine, İstanbul University, İstanbul, TurkeyMehmet Türker, Department of Orthopedics and Traumatology, Faculty of Medicine, Kirikkale University, Kirikkale, TurkeyFatih Yildız, Department of Orthopedics and Trau...
Source: European Journal of Orthopaedic Surgery and Traumatology - November 19, 2012 Category: Orthopaedics Tags: European Journal of Orthopaedic Surgery & Traumatology Source Type: research

Versatile application of short stem during total hip arthroplasty
In this report, we present two unique case scenarios where the use of short stems has given successful results. Content Type Journal ArticleCategory Up-to date Review and Case ReportPages 1-4DOI 10.1007/s00590-012-1128-3Authors Kwang-Jun Oh, Department of Orthopedic Surgery, Konkuk University School of Medicine, KonKuk University Medical Center, Seoul, KoreaJae-Hyuk Yang, Department of Orthopaedic Surgery, Veterans Health Service Medical Center, 6-2 Dunchon Dong, Kangdong Ku, Seoul, Korea Journal European Journal of Orthopaedic Surgery & TraumatologyOnline ISSN 1432-1068Print ISSN 1633-8065
Source: European Journal of Orthopaedic Surgery and Traumatology - November 19, 2012 Category: Orthopaedics Tags: European Journal of Orthopaedic Surgery & Traumatology Source Type: research

Anterior cruciate ligament (ACL) autograft reconstruction with hamstring tendons: clinical research among three rehabilitation procedures
Conclusion  Early rehabilitation is beneficial for restoration of knee function after ACL reconstruction. Moderate procedure is better than accelerated procedure. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00590-012-1106-9Authors Weimin Zhu, Department of Sports Medical, Shenzhen Second People Hospital, Sungang West Road, Futian District, Shenzhen, 518000 People’s Republic of ChinaDaping Wang, Department of Sports Medical, Shenzhen Second People Hospital, Sungang West Road, Futian District, Shenzhen, 518000 People’s Republic of ChinaYun Han, Department of Sports Med...
Source: European Journal of Orthopaedic Surgery and Traumatology - November 19, 2012 Category: Orthopaedics Tags: European Journal of Orthopaedic Surgery & Traumatology Source Type: research

Unilateral atlantal lateral mass hypertrophy associated with atlanto-occipital fusion
Conclusions  To our knowledge, such a case of unilateral atlantal mass hypertrophy associated with atlanto-occipital fusion has not been described previously. The authors discuss the pathology of this case and review the literature on unilateral atlantal mass hypertrophy and associated anomalies of the upper cervical spine. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s00586-012-2574-7Authors Eijiro Onishi, Department of Orthopedic Surgery, Kurashiki Central Hospital, Miwa 1-1-1, Kurashiki, Okayama 710-8602, JapanAkira Sakamoto, Department of Orthopedic Surgery, Kurashiki Cent...
Source: European Spine Journal - November 19, 2012 Category: Orthopaedics Tags: European Spine Journal Source Type: research

Management of hangman’s fracture with percutaneous transpedicular screw fixation
Conclusions  The fluoroscopically assisted percutaneous C2 transpedicular screw fixation method is a technically feasible and minimally invasive technique for hangman’s fracture. Content Type Journal ArticleCategory Ideas and Technical InnovationsPages 1-8DOI 10.1007/s00586-012-2578-3Authors Yao-Sen Wu, Department of Orthopaedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, 310009 ChinaYan Lin, Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, 109 Xueyuan Xi Road, Wenzhou, 325000 ChinaXiao-Lei Zhang, D...
Source: European Spine Journal - November 19, 2012 Category: Orthopaedics Tags: European Spine Journal Source Type: research

Relevance of intraoperative D wave in spine and spinal cord surgeries
Conclusions  Not only is intraoperative D wave recording to be considered mandatory in IMSCT surgery but it should also be attempted in other types of spine/spinal cord surgeries. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00586-012-2576-5Authors Paolo Costa, Section of Clinical Neurophysiology, CTO Hospital, Turin, ItalyPaola Peretta, Pediatric Neurosurgery, Regina Margherita Hospital, Turin, ItalyGiuliano Faccani, Neurosurgery, CTO Hospital, Turin, Italy Journal European Spine JournalOnline ISSN 1432-0932Print ISSN 0940-6719
Source: European Spine Journal - November 19, 2012 Category: Orthopaedics Tags: European Spine Journal Source Type: research

Osteochondral tissue engineering: Current strategies and challenges.
Abstract Osteochondral defect management and repair remain a significant challenge in orthopedic surgery. Osteochondral defects contain damage to both the articular cartilage as well as the underlying subchondral bone. In order to repair an osteochondral defect the needs of the bone, cartilage and the bone-cartilage interface must be taken into account. Current clinical treatments for the repair of osteochondral defects have only been palliative, not curative. Tissue engineering has emerged as a potential alternative as it can be effectively used to regenerate bone, cartilage and the bone-cartilage interface. Sever...
Source: Biotechnology Advances - November 19, 2012 Category: Biotechnology Authors: Nukavarapu SP, Dorcemus DL Tags: Biotechnol Adv Source Type: research

Nonsurgical Techniques to Control Massive Bleeding
Significant advancements in nonsurgical and surgical approaches to control bleeding in severely injured patients have also improved the treatment of critical trauma-related coagulopathy. Nonsurgical procedures such as angiographic embolization are progressively considered to terminate arterial bleeding from pelvic fractures. The disturbance of coagulation may aggravate bleeding and hamper surgical procedures. The administration of coagulation factors and factor concentrates may be useful for correcting systemic coagulopathy and reducing the need for fresh frozen plasma, platelet, and red blood cell transfusions, which are ...
Source: Anesthesiology Clinics - November 19, 2012 Category: Anesthesiology Authors: Christian Zentai, Oliver Grottke, Donat R. Spahn, Rolf Rossaint Source Type: research

Evaluation of a modified Broström–Gould procedure for treatment of chronic lateral ankle instability: A retrospective study with critical analysis of outcome scoring
Conclusion: Outcome of modified Broström–Gould procedure is good with high satisfaction rate in terms of ankle mobility. The disparity in outcome of scores, signals towards the need of a standard evaluation system.
Source: Foot and Ankle Surgery - November 19, 2012 Category: Orthopaedics Authors: Yannick Buerer, Michaela Winkler, Alexandre Burn, Swati Chopra, Xavier Crevoisier Tags: Original Articles Source Type: research

Gait characteristics and lower limb muscle strength in women with early and established knee osteoarthritis
This study assessed whether these early osteoarthritis patients already exhibit gait adaptations (knee joint loading in particular) and changes in muscle strength compared to control subjects and established knee osteoarthritis patients.Methods: Fourteen female patients with early knee joint degeneration, defined by magnetic resonance imaging (early osteoarthritis), 12 female patients with established osteoarthritis and 14 female control subjects participated. Specific gait parameters and lower limb muscle strength were analyzed and compared between groups. Within the osteoarthritis groups, association between muscle stren...
Source: Clinical Biomechanics - November 19, 2012 Category: Orthopaedics Authors: Isabel A.C. Baert, Ilse Jonkers, Filip Staes, Frank P. Luyten, Steven Truijen, Sabine M.P. Verschueren Tags: Papers Source Type: research

Single-stage posterior decompression and stabilization for metastasis of the thoracic spine: prognostic factors for functional outcome and patients' survival
Abstract: Background context: There are limited data analyzing radiological and clinical factors for the functional outcomes of surgery for spinal metastasis. Also, there are few studies to investigate the relationship between the functional outcome and the patients' survival. Thus, analysis of both functional outcomes and the survival with their relationship in a possibly homogenous group of patients is worth being reported.Purpose: To assess treatment outcomes of single-stage posterior decompression and stabilization (PDS) with or without corpectomy for thoracic vertebral metastases and to analyze factors affecting both ...
Source: The Spine Journal - November 19, 2012 Category: Orthopaedics Authors: Sangjoon Chong, Sang-Hoon Shin, Heon Yoo, Seung Hoon Lee, Ki-Jeong Kim, Tae-Ahn Jahng, Ho-Shin Gwak Tags: Clinical Studies Source Type: research

Metatarsocuneiform Joint Resection Arthroplasty for Atraumatic Osteoarthrosis: An Alternative to Arthrodesis
We present a technique not previously described. The procedure is presented as an alternative to arthrodesis and involves resection arthroplasty of the metatarsocuneiform joint.
Source: Journal of Foot and Ankle Surgery - November 19, 2012 Category: Orthopaedics Authors: Mark F. Gilheany, Ozan T. Amir Tags: Tips, Quips, and Pearls Source Type: research

Osteitis of the Fourth Metatarsal Caused by a Date Palm Thorn in a Child: Why the Dorsum of the Foot Is the Most Commonly Injured Site
We present a case of date palm thorn-induced periostitis of the base of the fourth metatarsal. Surgical exploration revealed a 2.5-cm palm tree thorn embedded in granulation tissue, forming an abscess. The lesion was successfully treated by curettage of the lesion and removal of the thorn embedded in the periosteum of the metatarsal base. The purpose of the present report was to explain the mechanism of this rare entity and the frequency of this lesion on the dorsal aspect of the foot rather than on the plantar. Despite the absence of a definite history of trauma, organic foreign material should be in the differential diag...
Source: Journal of Foot and Ankle Surgery - November 19, 2012 Category: Orthopaedics Authors: Mohammed Madhar, Younes Sammous, Jamal Bouslous, Tarik Messaoudi, Rachid Chafik, Hanane Elhaoury, Halim Saidi, Tarik Fikry Tags: Case Reports and Series Source Type: research

Outcomes of the Modified Brostrom Procedure Using Suture Anchors for Chronic Lateral Ankle Instability—A Prospective, Randomized Comparison between Single and Double Suture Anchors
Abstract: The present prospective, randomized study was conducted to compare the clinical outcomes of the modified Brostrom procedure using single and double suture anchors for chronic lateral ankle instability. A total of 50 patients were followed up for more than 2 years after undergoing the modified Brostrom procedure. Of the 50 procedures, 25 each were performed using single and double suture anchors by 1 surgeon. The Karlsson scale had improved significantly to 89.8 points and 90.6 points in the single and double anchor groups, respectively. Using the Sefton grading system, 23 cases (92%) in the single anchor group an...
Source: Journal of Foot and Ankle Surgery - November 19, 2012 Category: Orthopaedics Authors: Byung-Ki Cho, Yong-Min Kim, Dong-Soo Kim, Eui-Sung Choi, Hyun-Chul Shon, Kyoung-Jin Park Tags: Original Research Source Type: research

In Reply
We appreciate Drs Khanuja and Naziri for their comments regarding our article entitled, “Dislocation after total hip arthroplasty: a randomized clinical trial of a posterior approach and a modified lateral approach” .
Source: The Journal of Arthroplasty - November 19, 2012 Category: Orthopaedics Authors: Yong-Chan Ha Tags: Letters to the Editor Source Type: research

The 12th International Congress of Shoulder and Elbow Surgery
As the Co-Presidents of the 12th International Congress of Shoulder and Elbow Surgery (ICSES), we would like to thank Bill Mallon, Editor-in-Chief, for giving us this opportunity to introduce the upcoming ICSES in Nagoya, Japan. We originally planned to have this meeting in Kyoto in December 2013. However, due to the Great East Japan Earthquake and Tsunami of March 11th, 2011, the venue, Kyoto International Conference Center, was partly damaged and must undergo structural repairs and seismic reinforcement. This reinforcement procedure makes it impossible to use the building in December 2013. For this reason, we have chang...
Source: Journal of Shoulder and Elbow Surgery - November 19, 2012 Category: Orthopaedics Authors: Eiji Itoi, Kenji Takagishi Tags: Editorial Source Type: research

Answer to the letter to the editor “Quantitative bone ultrasound in pediatric patients with cystic fibrosis”
We thank Dr. JM Moran for his interest in our article on radial QUS in pediatric CF patients. We agree that the results of QUS in children suffering from chronic diseases affecting mineralization might be site specific and technique dependent. A large study of children with different chronic diseases showed that phalangeal QUS does not identify the same osteopenic patients as assessed by other techniques . Given our experience in CF with pQCT, documenting a reduced cortical thickness at the radius, we have chosen radial QUS to have a similar site measurement and because of its dependence on cortical bone . In our study, we...
Source: Journal of Cystic Fibrosis - November 19, 2012 Category: Respiratory Medicine Authors: Jean De Schepper Tags: Correspondence Source Type: research

Dislocation After Total Hip Arthroplasty: A Randomized Clinical Trial of a Posterior Approach and a Modified Lateral Approach
We appreciate Drs Khanuja and Naziri for their comments regarding our article entitled, “Dislocation after total hip arthroplasty: a randomized clinical trial of a posterior approach and a modified lateral approach” .
Source: The Journal of Arthroplasty - November 19, 2012 Category: Orthopaedics Authors: Yong-Chan Ha Tags: Letters to the Editor Source Type: research

Revision Total Hip Arthroplasty Using an Alumina-On-Alumina Bearing Surface in Patients With Osteolysis
Abstract: We evaluated the outcomes of 64 consecutive revision total hip arthroplasties with an alumina-on-alumina bearing surface in 61 patients with osteolysis. No implants had been rerevised nor was osteolysis detected at a mean of 9.8 years (range, 7.0-13.1 years) postoperatively. There was 1 case of stem loosening but no cup loosening or alumina bearing fractures. Two surgical procedures were performed for an infection in 1 patient. Three dislocations occurred in 3 hips; all were treated with closed reduction and abduction bracing for 3 months. No further dislocations occurred. With any reoperation or radiographic evi...
Source: The Journal of Arthroplasty - November 19, 2012 Category: Orthopaedics Authors: Jeong Joon Yoo, Pil Whan Yoon, Young-Kyun Lee, Kyung-Hoi Koo, Kang Sup Yoon, Hee Joong Kim Tags: Original Articles Source Type: research

miR-326 associates with biochemical markers of bone turnover in lung cancer bone metastasis
In this study, we aimed to identify novel miRNAs associated with skeletal metastatic disease in a preclinical model of lung cancer bone metastasis. We assessed the validity of these miRNAs as reliable serum biochemical markers to monitor the extent of disease and response to treatment in comparison to imaging techniques and standard biochemical markers of bone turnover. Using a murine model of human lung cancer bone metastasis after zoledronic acid (ZA) treatment, PINP (procollagen I amino-terminal propeptide) was the only marker that exhibited a strong correlation with osteolytic lesions and tumor burden at early and late...
Source: Bone - November 19, 2012 Category: Orthopaedics Authors: Karmele Valencia, Marta Martín-Fernández, Carolina Zandueta, Cristina Ormazábal, Susana Martínez-Canarias, Eva Bandrés, Concepción de la Piedra, Fernando Lecanda Tags: Original Articles Source Type: research

Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women: The ROAD Study
The objective of this study was to clarify the associations of physical performance and bone and joint diseases with single and multiple falls in Japanese men and women using a population-based longitudinal cohort study known as Research on Osteoarthritis/osteoporosis Against Disability (ROAD). A total of 452 men and 896 women were analyzed in the present study (mean age, 63.9years). A questionnaire was used to assess the number of falls during the 3-year follow-up. Grip strength, 6-m walking time, and chair stand time were measured at baseline. Knee osteoarthritis (OA) and lumbar spondylosis were defined as Kellgren Lawre...
Source: Bone - November 19, 2012 Category: Orthopaedics Authors: Shigeyuki Muraki, Toru Akune, Yuyu Ishimoto, Keiji Nagata, Munehito Yoshida, Sakae Tanaka, Hiroyuki Oka, Hiroshi Kawaguchi, Kozo Nakamura, Noriko Yoshimura Tags: Original Articles Source Type: research

Does the placement of a cystic duct tube after a hepatic resection help reduce the incidence of post‐operative bile leak?
ConclusionThe usefulness of the C tube in preventing post‐hepatectomy bile leak could not be confirmed; however, both bile leak requiring clinical management and long hospitalization after a major hepatectomy could be reduced with C tube use.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - November 19, 2012 Category: Gastroenterology Authors: Atsushi Nanashima, Takafumi Abo, Ayako Shibuya, Tetsuro Tominaga, Aya Matsumoto, Kazuo Tou, Masaki Kunizaki, Hiroaki Takeshita, Shigekazu Hidaka, Tomoshi Tsuchiya, Naoya Yamasaki, Takeshi Nagayasu Tags: ORIGINAL ARTICLE Source Type: research

Effect of autologous platelet‐rich plasma on bone regeneration in mandibular fractures
ConclusionsIt can be concluded that direct application of the PRP along the fracture lines may enhance the bone regeneration in mandibular fractures.
Source: Dental Traumatology - November 19, 2012 Category: Dentistry Authors: Emad T. Daif Tags: Original Article Source Type: research

Administration of calcitonin promotes blastocyst implantation in mice by up-regulating integrin {beta}3 expression in endometrial epithelial cells
STUDY QUESTION Does exogenous calcitonin improve the efficiency of implantation in mice by increasing uterine receptivity? SUMMARY ANSWER The administration of calcitonin could improve the efficiency of implantation by increasing the expression of several receptivity-related genes in endometrial epithelial cells (EECs). WHAT IS KNOWN ALREADY Calcitonin is one of the biomarkers of uterine receptivity, which is transiently produced in the uterine epithelia during the period of implantation both in humans and mouse. STUDY DESIGN, SIZE, DURATION Hormone-replaced mice were used for in vivo experiments. To evaluate the effect...
Source: Human Reproduction - November 19, 2012 Category: Reproduction Medicine Authors: Xiong, T., Zhao, Y., Hu, D., Meng, J., Wang, R., Yang, X., Ai, J., Qian, K., Zhang, H. Tags: Reproductive biology Source Type: research

Medical complications, clinical findings, and educational outcomes in adults with Noonan syndrome
Abstract Noonan syndrome (NS) is a heterogeneous developmental disorder caused by missense mutations in genes involved in the Ras/MAPK signaling pathway, a major mediator of early and late developmental processes. The diagnosis of NS is made on clinical grounds with molecular confirmation of a mutation found in 63% of cases. Key clinical features include short stature, cardiac defects, developmental delay, lymphatic dysplasias, bleeding tendency, and a constellation of distinctive facial features and physical exam findings. The prevalence of medical issues or the development of new ones in adults with NS is not well‐stud...
Source: American Journal of Medical Genetics Part A - November 19, 2012 Category: Genetics & Stem Cells Authors: Patroula Smpokou, Erica Tworog‐Dube, Raju S. Kucherlapati, Amy E. Roberts Tags: Research Article Source Type: research

Theoretical model of the effect of combined glenohumeral bone defects on anterior shoulder instability: A finite element approach
Abstract The presence of either a Hill–Sachs or a bony Bankart defect has been indicated as a possible cause of subluxation and anterior shoulder dislocation. Previous studies investigated only the effects of isolated humeral or glenoid defects on glenohumeral instability. We investigated the effects on shoulder stability of both glenoid and humeral defects in the glenohumeral joint. A computer‐based finite element approach was used to model the joint. A generic model was developed for cartilage and bone of the glenoid and humerus, using previously published data, and experiments were analyzed using static analysis wit...
Source: Journal of Orthopaedic Research - November 19, 2012 Category: Orthopaedics Authors: Piyush Walia, Anthony Miniaci, Morgan H. Jones, Stephen D. Fening Tags: Research Article Source Type: research

Silencing the expression of connexin 43 decreases inflammation and joint destruction in experimental arthritis
The objective of the present study was to determine whether the expression of connexin 43 (Cx43) effected on inflammatory conditions in rat fibroblast‐like synoviocytes (FLS) and on rat model of rheumatoid arthritis (RA). The expression of Cx43 in rat FLS stimulated with lipopolysaccharide (LPS) was confirmed by real‐time reverse transcriptase polymerase chain reaction (RT‐PCR). The effects of small‐interfering RNA targeting Cx43 (siCx43) on pro‐inflammatory cytokines and chemokine were assessed by real‐time RT‐PCR and enzyme‐linked immunosorbent assay (ELISA). The therapeutic and side effects of siCx43 in ...
Source: Journal of Orthopaedic Research - November 19, 2012 Category: Orthopaedics Authors: Shinji Tsuchida, Yuji Arai, Tsunao Kishida, Kenji A. Takahashi, Kuniaki Honjo, Ryu Terauchi, Hiroaki Inoue, Ryo Oda, Osam Mazda, Toshikazu Kubo Tags: Research Article Source Type: research

Patellar maltracking is prevalent among patellofemoral pain subjects with patella alta: An upright, weightbearing MRI study
This study adds to our understanding of PF pain in two ways—(1) we demonstrate that patellar maltracking is more prevalent in PF pain subjects with patella alta compared to subjects with normal patella height; and (2) we show greater patella height in PF pain subjects compared to pain free subjects using four indices commonly used in clinics. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
Source: Journal of Orthopaedic Research - November 19, 2012 Category: Orthopaedics Authors: Saikat Pal, Thor F. Besier, Gary S. Beaupre, Michael Fredericson, Scott L. Delp, Garry E. Gold Tags: Research Article Source Type: research

Recessively inherited forms of osteogenesis imperfecta.
Abstract More than 90% of people who have osteogenesis imperfecta (OI) have heterozygous mutations in one of the two type I collagen genes, COL1A1 and COL1A2. The effects of these changes range from death in the perinatal period to barely increased fracture frequency and reflect different types of mutations. Introduction of bisphosphonates during the past 20 years has targeted bone fragility by decreased resorption. The recent recognition of biallelic mutations in genes that affect either collagen assembly and processing or the regulation of osteoblast development has raised hopes for therapies that would be specif...
Source: Annual Review of Genetics - November 18, 2012 Category: Genetics & Stem Cells Authors: Byers PH, Pyott SM Tags: Annu Rev Genet Source Type: research

Microsurgical medial fenestration with an ultrasonic bone curette for lumbar foraminal stenosis.
Conclusions: Microsurgical medial fenestration using Sonopet, a less-invasive surgical technique that does not result in spinal instability or malalignment, yielded excellent clinical outcomes. PMID: 23123388 [PubMed - in process]
Source: Journal of Nippon Medical School - November 17, 2012 Category: Universities & Medical Training Authors: Morimoto D, Isu T, Kim K, Sugawara A, Matsumoto R, Isobe M Tags: J Nippon Med Sch Source Type: research

Acoustic stimulation promotes DNA fragmentation in the Guinea pig cochlea.
In this study, we used immunohistochemical and electrophysiological methods to examine the fragmentation of DNA in the cochleas of guinea pigs that had been exposed to intense noise. Twenty-four guinea pigs weighing 250 to 350 g were used. The animals were divided into 4 groups: (I) a control group (n=6), (II) a group that was exposed to noise for 2 hours (n=6), (III) a group that was exposed to noise for 5 hours (n=6), and (IV) a group that was exposed to noise for 20 hours. The stimulus was a pure tone delivered at a frequency of 2 kHz. The sound pressure level was 120 dBSPL. No threshold shifts were apparent in group I....
Source: Journal of Nippon Medical School - November 17, 2012 Category: Universities & Medical Training Authors: Kamio T, Watanabe K, Okubo K Tags: J Nippon Med Sch Source Type: research

Bone Mineral Density Status: It s Complicated
[caption id="attachment_655" align="alignleft" width="256" caption="The femoral head. Public domain image via Wikimedia Commons."] [/caption]Lady bones are delicate, selfless, dense connective tissue that hold lady bodies up to help the lady vessel carry babies. When we are pregnant, the thinking goes, lady bones give up their calcium in vast quantities, depleting themselves for the good of their darling fetuses. We ladies mostly replete this calcium between pregnancies. Then of course, when we lose our essential lady-ness in the form of menopause, our lady bones go all to hell, so Sally Field gives us a monthly dose of B...
Source: Scientific American - Official RSS Feed - November 16, 2012 Category: Science Tags: Evolution Source Type: research

Do Ethnic Differences Still Exist in Pain Assessment and Treatment in the Emergency Department?
Abstract: Although the provision of timely and appropriate analgesia is a primary goal of Emergency Department (ED) staff, pain continues to be undertreated and some evidence supports the existence of pain treatment disparities. Despite strong incentives from accreditation organizations, pain management in the ED may still be inconsistent and problematic. The purpose of this research study was to conduct a retrospective chart review to investigate pain assessment and treatment for 200 adults (≥18 years old) admitted to the ED suffering from long-bone fractures. An additional purpose was to investigate demographic variabl...
Source: Pain Management Nursing - November 16, 2012 Category: Nursing Authors: Laurie Jowers Ware, Cynthia D. Epps, Julie Clark, Ayona Chatterjee Tags: Original Articles Source Type: research

[Perspectives] Surgery sanctified
The British sculptor Barbara Hepworth (1903–75) met orthopaedic surgeon Norman Capener in 1944, an encounter that proved to be fruitful in many ways. One of Hepworth and her husband Ben Nicholson's triplets, Sarah, had osteomyelitis and Capener had operated on her at the Princess Elizabeth Orthopaedic Hospital in Exeter. The artists struck up a friendship with the surgeon, and Capener later visited the family in St Ives where, in 1947, Hepworth taught him to carve.
Source: LANCET - November 16, 2012 Category: Journals (General) Authors: Colin Martin Tags: Perspectives Source Type: research

[Comment] Hip resurfacing: a complex challenge for device regulation
Metal-on-metal hip failure is the most widespread medical device failure of the past decade, The UK's Medicines and Healthcare products Regulatory Agency recently issued an updated alert and recommendations about managing patients with metal-on-metal hip implants, and in June, 2012, the US Food and Drug Administration (FDA) held a meeting of the Orthopaedic and Rehabilitation Devices Panel of the Medical Devices Advisory Committee to discuss the evidence. Although stemmed or conventional metal-on-metal hip replacement was discussed extensively at the meeting, hip resurfacing—a more bone-preserving procedure using a metal...
Source: LANCET - November 16, 2012 Category: Journals (General) Authors: Art Sedrakyan Tags: Comment Source Type: research

Semimembranosus Release as the Second Step of Soft Tissue Balancing in Varus Total Knee Arthroplasty
Abstract: There have been limited clinical data on the effect of semimembranosus release in patients with varus knees treated with total knee arthroplasty (TKA). The purposes of this study were to determine the effect of semimembranosus release and to evaluate the effectiveness of our release technique based on the three-step algorithm which consisted of sequential release of 1) deep medial collateral ligament (MCL), 2) semimembranosus, 3) superficial MCL in 104 consecutive varus knees treated with TKA. Semimembranosus release had the desired effect on gap balancing in varus knees and our algorithmic medial release approac...
Source: The Journal of Arthroplasty - November 16, 2012 Category: Orthopaedics Authors: Hae Seok Koh, Yong In Tags: Original Articles Source Type: research

An experimental study of the interface pressure profile during level walking of a new suspension system for lower limb amputees
This study aimed to compare the interface pressure of a new magnetic suspension system with the pin/lock and Seal-In suspension systems.Methods: Twelve unilateral transtibial amputees participated in the study. The subjects walked on a level walkway at a self-selected speed. The resultant peak pressure with the three different suspension systems was recorded using F-socket transducers.Findings: There were significant statistical differences between the three studied suspension systems. Pair-wise analyses revealed that the mean peak pressure (kPa) was lower with the magnetic system than it was with the pin/lock system over ...
Source: Clinical Biomechanics - November 16, 2012 Category: Orthopaedics Authors: Arezoo Eshraghi, Noor Azuan Abu Osman, Hossein Gholizadeh, Sadeeq Ali, Stefán Karl Sævarsson, Wan Abu Bakar Wan Abas Tags: Papers Source Type: research