Orthopaedics Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Cardiovascular and Noncardiovascular Disease Associations with Hip Fractures
Conclusions: Although the association with hip fracture was not specific to cardiovascular disease, temporal increases were mainly detected in cardiometabolic diseases, all of which have been linked previously to frailty. This mechanism and others warrant further investigation.
Source: The American Journal of Medicine - January 16, 2013 Category: Journals (General) Authors: Yariv Gerber, L. Joseph Melton, Sheila M. McNallan, Ruoxiang Jiang, Susan A. Weston, Véronique L. Roger Tags: Clinical research studies Source Type: research

Cost-Effectiveness of Osteoporosis Interventions for 'Incidental' Vertebral Fractures
Conclusions: Pragmatic and inexpensive interventions directed at patients with incidentally detected vertebral fractures and their physicians are highly cost-effective at improving osteoporosis treatment, and in most circumstances also are cost-saving.
Source: The American Journal of Medicine - January 16, 2013 Category: Journals (General) Authors: Sumit R. Majumdar, Douglas A. Lier, Finlay A. McAlister, Brian H. Rowe, Kerry Siminoski, David A. Hanley, Anthony S. Russell, Jeffrey A. Johnson Tags: Clinical research studies Source Type: research

Altitude and Forest Edges Influence the Density and Distribution of Pygmy Tarsiers (Tarsius pumilus)
In this study, we examine how high‐altitude ecology and anthropogenic edges relate to the density and distribution of pygmy tarsiers. Pygmy tarsiers (Tarsius pumilus) are extremely small‐bodied primates (55 g) that are endemic to high‐altitude forest and exhibit several differences from lowland Sulawesian tarsier species. From June to September 2010 and January to March 2012, we conducted a population census of pygmy tarsiers across multiple altitudes. Sampling took place within a 1.2 km2 area encompassing altitudes of 2,000–2,300 m a.s.l. on Mt. Rore Katimbu in Lore Lindu National Park, central Sulawesi, Indonesia...
Source: American Journal of Primatology - January 16, 2013 Category: Psychiatry & Psychology Authors: Nanda Grow, Sharon Gursky, Yulius Duma Tags: RESEARCH ARTICLE Source Type: research

The bone tissue compatibility of a new Ti35Nb2Ta3Zr alloy with a low Young's modulus.
In conclusion, the Ti35Nb2Ta3Zr alloy with a lower elastic modulus closer to that of human bone has significant bone tissue compatibility equal to that of Ti6Al4V, which has been widely used in orthopedic applications. PMID: 23338484 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - January 16, 2013 Category: Molecular Biology Authors: Guo Y, Chen D, Cheng M, Lu W, Wang L, Zhang X Tags: Int J Mol Med Source Type: research

In vitro assessment of Function Graded (FG) artificial Hip joint stem in terms of bone/cement stresses: 3D Finite Element (FE) study
Conclusion: FE results showed that using FG stem increases the resultant stresses at the femur bone (reduces stress shielding) compared to metallic stem. The results showed that the stem length has significant effects on the resultant shear and Von Mises stresses at bone, stem and bone cement for all types of stem materials.
Source: BioMedical Engineering OnLine - January 16, 2013 Category: Biomedical Engineering Authors: Fawzi Al-JassirHassan FouadOthaman Alothman Source Type: research

Comorbidity in patients with chronic obstructive pulmonary disease in family practice: a cross sectional study
Conclusions: Patients with COPD, who are frequent in family practice, have a complex profile and pose a clinical and organisational challenge to FPs.
Source: BMC Family Practice - January 16, 2013 Category: Primary Care Authors: Luis García-OlmosÁngel AlberquillaVictoria AyalaPilar García-SagredoLeticia MoralesMontserrat CarmonaMaría de Tena-DávilaMario PascualAdolfo MuñozCarlos SalvadorJose Monteagudo Source Type: research

Illness perceptions in patients receiving rheumatology rehabilitation: association with health and outcomes at 12 months
Conclusion: Illness perceptions as measured by the RD-IPQ were associated with health and outcomes as measured by rheumatology-specific and generic instruments. The consideration of illness perceptions as a component of rehabilitation may be important in achieving desired outcomes.
Source: BMC Musculoskeletal Disorders - January 16, 2013 Category: Orthopaedics Authors: Ida LøchtingElin FjerstadAndrew Garratt Source Type: research

Does a bipolar hemiprosthesis offer advantages for elderly patients with neck of femur fracture? A clinical trial with 261 patients
ConclusionThese short‐term results suggest that unipolar implants share many of the advantages of the bipolar prosthesis but can be manufactured at substantially lower cost. These implants may be appropriate for the less‐active elderly patient, particularly when used with bone cement.
Source: ANZ Journal of Surgery - January 16, 2013 Category: Surgery Authors: Karl K. Stoffel, Bo Nivbrant, Julie Headford, Rochelle L. Nicholls, Piers J. Yates Tags: Original Article Source Type: research

Developing a model osteoarthritis consultation: a Delphi consensus exercise
Conclusions: This study has enabled the priorities of GPs and patients to be identified for a model OA consultation. The results of this consensus study will inform the development of best practice for the management of OA in primary care and the implementation of evidence-based guidelines for OA in primary care.
Source: BMC Musculoskeletal Disorders - January 16, 2013 Category: Orthopaedics Authors: Mark PorcheretJanet GrimeChris MainKrysia Dziedzic Source Type: research

A new web-based method for automated analysis of muscle histology
Conclusions: A standardised and mainly automated quantitative assessment of histopathological parameters in the mdx mouse model is now available. Automated analysis of histological parameters is more rapid and less time-consuming. Moreover, results are unbiased and more reliable. Efficacy of therapeutic interventions, e.g. within the scope of a drug screening or therapeutic exon skipping, can be monitored. The automatic analysis system MyoScan used in this study is not limited exclusively to dystrophin-deficient mice but also represents a useful tool for applications in the research of other dystrophic pathologies, various...
Source: BMC Musculoskeletal Disorders - January 16, 2013 Category: Orthopaedics Authors: Cordula PertlMarkus EblenkampAnja PertlStefan PfeiferErich WintermantelHanns LochmüllerMaggie WalterSabine KrauseChristian Thirion Source Type: research

Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix deposition
Conclusions: Pre-solidified implants elicit stromal cells and vigorous bone plate remodeling through a phase involving neutrophil chemotaxis. Pre-solidified chitosan implants are tunable by molecular mass, and could be beneficial for augmented marrow stimulation therapy if the recruited stromal cells can progress to bone and cartilage repair.
Source: BMC Musculoskeletal Disorders - January 16, 2013 Category: Orthopaedics Authors: Charles-Hubert Lafantaisie-FavreauJessica Guzmán-MoralesJun SunGaoping ChenAdam HarrisThomas SmithAlberto CarliJanet HendersonWilliam StanishCaroline Hoemann Source Type: research

Current Challenges and Concepts of the Thermomechanical Treatment of Nickel-Titanium Instruments
Conclusions: The aim of this review was to provide clinicians with the knowledge necessary for evidence-based practices, maximizing the benefits from the selection and application of NiTi rotary instruments for root canal treatment.
Source: Journal of Endodontics - January 15, 2013 Category: Dentistry Authors: Ya Shen, Hui-min Zhou, Yu-feng Zheng, Bin Peng, Markus Haapasalo Tags: Review Article Source Type: research

Beneficial effects of phytoestrogens and their metabolites produced by intestinal microflora on bone health.
Abstract Phytoestrogens are a class of bioactive compounds derived from plants and exert various estrogenic and antiestrogenic effects. Estrogen deficiency osteoporosis has become a serious problem in elderly women. The use of ovariectomized (OVX) rat or mice models to simulate the postmenopausal condition is well established. This review aimed to clarify the sources, biochemistry, absorption, metabolism, and mode of action of phytoestrogens on bone health in intervention studies. In vitro, phytoestrogens promote protein synthesis, osteoprotegerin/receptor activation of nuclear factor-kappa B ligand ratio, and mine...
Source: Applied Microbiology and Biotechnology - January 15, 2013 Category: Microbiology Authors: Chiang SS, Pan TM Tags: Appl Microbiol Biotechnol Source Type: research

Bone substitute materials delivering zoledronic acid: Physicochemical characterization, drug load, and release properties
Calcium phosphate-like bone substitute materials have a long history of successful orthopedic applications such as bone void filling and augmentation. Based on the clinical indications, these materials may be loaded with active agents by adsorption offering a perspective for providing innovative drug-delivery systems. The highly effective bisphosphonate zoledronic acid (ZOL) demonstrated a strong affinity to biominerals and is known to significantly reduce osteoclastic activity. Support of early bone formation and reduction of bone resorption can be promoted after implantation of bioceramics releasing ZOL. The aim of this ...
Source: Journal of Biomaterials Applications - January 15, 2013 Category: Materials Science Authors: Sorensen, T. C., Arnoldi, J., Procter, P., Robioneck, B., Steckel, H. Tags: Articles Source Type: research

What can we learn from a patient on dialysis for 42 years?
Abstract We performed autopsy on a 60-year-old Japanese man who had received dialysis for 42 years. He started on intermittent peritoneal dialysis in 1968, which was combined with hemodialysis in 1969. His serum calcium-phosphate balance and his blood pressure had been controlled well. Carpal tunnel syndrome occurred in 1984. Then lumbar spinal canal stenosis (SCS) occurred in 1997, followed by cervical SCS in 2000, destructive lumbar spondyloarthropathy (DSA) in 2002, and pathological fracture of the right femoral neck due to an enlarging bone cyst in 2006. All of his surgical specimens showed dialysis-related dep...
Source: Clinical Nephrology - January 15, 2013 Category: Urology & Nephrology Authors: Suwabe T, Ubara Y, Inoue M, Kitajima I, Oohashi K, Nakano I, Takaichi K Tags: Clin Nephrol Source Type: research

Bilateral and multiple cavitation sounds during upper cervical thrust manipulation
Conclusions: Cavitation was significantly more likely to occur bilaterally than unilaterally during upper cervical HVLA thrust manipulation. Most subjects produced 3--4 pops during a single rotatory HVLA thrust manipulation targeting the right or left C1-2 articulation; therefore, practitioners of spinal manipulative therapy should expect multiple popping sounds when performing upper cervical thrust manipulation to the atlanto-axial joint. Furthermore, the traditional manual therapy approach of targeting a single ipsilateral or contralateral facet joint in the upper cervical spine may not be realistic.
Source: BMC Musculoskeletal Disorders - January 15, 2013 Category: Orthopaedics Authors: James DunningFiras MouradMarco BarberoDiego LeoniCorrado CesconRaymond Butts Source Type: research

Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment [Musculoskeletal Imaging]
Giant cell tumor (GCT) of bone is generally a benign tumor composed of mononuclear stromal cells and characteristic multinucleated giant cells that exhibit osteoclastic activity. It usually develops in long bones but can occur in unusual locations. The typical appearance is a lytic lesion with a well-defined but nonsclerotic margin that is eccentric in location, extends near the articular surface, and occurs in patients with closed physes. However, GCT may have aggressive features, including cortical expansion or destruction with a soft-tissue component. Fluid-fluid levels, consistent with secondary formation of aneurysmal...
Source: Radiographics recent issues - January 15, 2013 Category: Radiology Authors: Chakarun, C. J., Forrester, D. M., Gottsegen, C. J., Patel, D. B., White, E. A., Matcuk, G. R. Tags: Magnetic Resonance Imaging, Musculoskeletal Radiology Musculoskeletal Imaging Source Type: research

Spectrum of Critical Imaging Findings in Complex Facial Skeletal Trauma [Trauma/Emergency Radiology]
Multidetector computed tomography (CT) is the modality of choice for the evaluation of facial trauma because it helps accurately identify and characterize fractures and associated complications, thereby aiding timely clinical management and surgical planning. In particular, CT clearly depicts clinically relevant fractures in the eight osseous struts or buttresses that function as an underlying scaffold for facial structures. Information about the involvement of specific facial buttresses in a complex fracture is helpful for determining the type of fracture present and for identifying associated soft-tissue injuries that ma...
Source: Radiographics recent issues - January 15, 2013 Category: Radiology Authors: Winegar, B. A., Murillo, H., Tantiwongkosi, B. Tags: Musculoskeletal Radiology, Computed Tomography, Emergency Radiology, Head and Neck Trauma/Emergency Radiology Source Type: research

Intimate partner violence and Musculoskeletal injury: bridging the knowledge gap in Orthopaedic fracture clinics
Sheila Sprague and colleagues review evidence from surgical research in the field of intimate partner violence (IPV) and provide recommendations for the development of an IPV identification and support program.
Source: BMC Musculoskeletal Disorders - January 15, 2013 Category: Orthopaedics Authors: Sheila SpragueKim MaddenSonia DosanjhKatelyn GodinJohan GoslingsEmil SchemitschMohit Bhandari Source Type: research

Memorial Hermann The Woodlands opens new tower
Memorial Hermann The Woodlands Hospital is rolling out the opening of its seven-story, $80 million patient tower, with plans to open new units over the next few years. The 240,000-square-foot expansion was completed in November and added eight additional surgical suites and surgical support services. Four floors are available for build-out projects. The hospital has plans to add a $6 million joint replacement unit, with requests for proposals to go out soon, hospital CEO Steve Sanders said. The…
Source: bizjournals.com Health Care:Hospitals headlines - January 14, 2013 Category: Hospital Management Authors: Bayan Raji Source Type: research

Nonarthroplasty Hip Surgery for Early Osteoarthritis
The most favorable mechanical environment for the hip is one that is free of both instability and impingement, creating a concentric articulation with optimum femoral head coverage by the acetabulum. Anatomic variations such as acetabular dysplasia with associated instability, and femoroacetabular impingement with abnormal constraint, will lead to abnormal joint mechanics, articular damage, and osteoarthritis. Surgical techniques such as periacetabular osteotomies, and femoral and acetabular osteoplasties enable correction of anatomic variations that cause mechanical damage to the hip joint, thereby potentially preventing ...
Source: Rheumatic Disease Clinics of North America - January 14, 2013 Category: Rheumatology Authors: Stephanie Y. Pun, John M. O’Donnell, Young-Jo Kim Source Type: research

The Interrater Reliability of Physical Examination Tests That May Predict the Outcome or Suggest the Need for Lumbar Stabilization Exercises
CONCLUSION: With the exception of the active hip abduction test, all other clinical tests can be considered sufficiently reliable for clinical use. The relatively small sample size likely contributed to the fairly wide confidence intervals around some of the reliability indices.J Orthop Sports Phys Ther 2013;43(2):83-90. Epub 14 January 2013. doi:10.2519/jospt.2013.4310KEY WORDS: clinical prediction rule, low back pain, lumbar segmental instability
Source: The Journal of Orthopaedic and Sports Physical Therapy - January 14, 2013 Category: Physiotherapy Tags: February 2013 Volume 43, No. 2 Source Type: research

Falls Among Patients Who Had Elective Orthopaedic Surgery: A Decade of Experience From a Musculoskeletal Specialty Hospital
CONCLUSION: Falls are avoidable events that are poorly described among orthopaedic patients having elective procedures. This large series identifies hip replacement patients as being at almost 4-fold risk of having a serious adverse event after falling. Larger prospective trials are needed to confirm results and to inform prevention strategies.J Orthop Sports Phys Ther 2013;43(2):91-96. Epub 14 January 2013. doi:10.2519/jospt.2013.4349KEY WORDS: adverse event, fear-avoidance, hip replacement, injury, inpatient care, postoperative risk
Source: The Journal of Orthopaedic and Sports Physical Therapy - January 14, 2013 Category: Physiotherapy Tags: February 2013 Volume 43, No. 2 Source Type: research

Abdominal Pain in Physical Therapy Practice: 3 Patient Cases
This report describes the management of 3 adults with primary complaints of abdominal pain who were referred for physical therapy evaluation and treatment. DIAGNOSIS: Two of the patients had secondary symptoms of hip and/or low back pain and had previously undergone extensive medical testing for their chronic abdominal pain, without a definitive diagnosis having been determined. A physical therapy evaluation was conducted, and treatment, including manual physical therapy and exercise, was administered to address all relative impairments, once the physical therapist had determined that the patients’ symptoms were of m...
Source: The Journal of Orthopaedic and Sports Physical Therapy - January 14, 2013 Category: Physiotherapy Tags: February 2013 Volume 43, No. 2 Source Type: research

Risk Factors for Persistent Problems Following Acute Whiplash Injury: Update of a Systematic Review and Meta-analysis
CONCLUSION: This review identified 2 additional prognostic factors and refined the estimates of 7 previously identified factors, bringing the total number of significant predictors across the 2 reviews to 12. These factors can be easily identified in a clinical setting to provide estimates of prognosis following whiplash. LEVEL OF EVIDENCE: Prognosis, level 1a.J Orthop Sports Phys Ther 2013;43(2):31-43. Epub 14 January 2013. doi:10.2519/jospt.2013.4507KEY WORDS: cervical spine, neck, prognosis, WAD
Source: The Journal of Orthopaedic and Sports Physical Therapy - January 14, 2013 Category: Physiotherapy Tags: February 2013 Volume 43, No. 2 Source Type: research

Preclinical and Clinical Studies on the use of Growth Factors for Bone Repair: A Systematic Review.
Conclusions: Bone Morphogenic Proteins and Platelet Rich Plasma, which contains multiple growth factors, have been shown in preclinical and clinical trials to be an effective alternative to autologous bone graft. Bone Morphogenic Proteins have been shown to be effective in fracture non union, and in open tibial fractures. Platelet Rich Plasma has shown promise in preclinical trials and some small clinical trials, however numbers are limited. Bone Morphogenic Proteins have been shown to be superior to Platelet Rich Protein in one trial. Combining these growth factors with tissue engineering techniques is the focus of ongoin...
Source: Current Stem Cell Research and Therapy - January 14, 2013 Category: Stem Cells Authors: Fisher DM, Wong JM, Crowley C, Khan WS Tags: Curr Stem Cell Res Ther Source Type: research

Human Wharton's Jelly mesenchymal stem cells maintain the expression of key immunomodulatory molecules when subjected to osteogenic, adipogenic and chondrogenic differentiation in vitro: new perspectives for cellular therapy.
Abstract Rheumatoid arthritis and osteoarthritis are the main diseases that imply to inflammatory process at the joint involving the articular cartilage. Recently, mesenchymal stem cells (MSCs) derived from perinatal tissues were considered a good candidates for cellular therapy of muskoloskeletal and orthopaedic diseases, because they can differentiate into multiple cell types and are an easily accessible cellular source. Therefore, several protocols exist on differentiation of mesenchymal stem cells of different origins into osteoblasts and chondrocytes. Another key feature of MSCs is their capacity to modulate t...
Source: Current Stem Cell Research and Therapy - January 14, 2013 Category: Stem Cells Authors: La Rocca G, Lo Iacono M, Corsello T, Corrao S, Farina F, Anzalone R Tags: Curr Stem Cell Res Ther Source Type: research

Clinical Measurement of Scapular Upward Rotation in Response to Acute Subacromial Pain.
CONCLUSION: Acute subacromial pain elicited an increase in scapular upward rotation at all angles of humeral elevation tested. This adaptation to acute experimental pain may provide protective compensation to subacromial structures during humeral elevation.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4276. PMID: 23321770 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Wassinger CA, Sole G, Osborne H Tags: J Orthop Sports Phys Ther Source Type: research

Cross-cultural Adaptation and Measurement Properties of the Brazilian Portuguese Version of the Victorian Institute of Sport Assessment - Patella (VISA-P) Scale.
CONCLUSIONS: The VISA-P Brazil is a reproducible and responsive tool and can be used in clinical practice and research to assess the severity of pain and disability of patients with patellar tendinopathy.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4287. PMID: 23321783 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Wageck BB, de Noronha M, Lopes AD, da Cunha RA, Takahashi RH, Costa LO Tags: J Orthop Sports Phys Ther Source Type: research

The Interrater Reliability of Physical Examination Tests That May Predict the Outcome or Suggest the Need for Lumbar Stabilization Exercises.
CONCLUSION: With the exception of the AHAbd, all other clinical tests can be considered sufficiently reliable for clinical use. The relatively small sample size likely contributed to the fairly wide confidence intervals around some of the reliability indices.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4310. PMID: 23321848 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Rabin A, Shashua A, Pizem K, Dar G Tags: J Orthop Sports Phys Ther Source Type: research

Diagnostic Accuracy of Clinical Tests for Assessment of Hamstring Injury: A Systematic Review.
CONCLUSION: Very few studies have investigated the utilization of clinical special tests for the diagnosis of hamstring injuries. Further studies of higher quality design are suggested prior to advocating independent clinical utilization of these special tests. LEVEL OF EVIDENCE: Diagnosis, Level 2a.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4343. PMID: 23321899 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Reiman MP, Loudon JK, Goode AP Tags: J Orthop Sports Phys Ther Source Type: research

Quality of Systematic Reviews on Specific Spinal Stabilization Exercise for Chronic Low Back Pain.
CONCLUSIONS: This review of SRs identified several high quality reviews which indicate some benefit of specific stabilization exercise programs for patients with non-specific chronic LBP. LEVEL OF EVIDENCE: Therapy, level 1a.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4346. PMID: 23321935 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Haladay DE, Miller SJ, Challis J, Denegar CR Tags: J Orthop Sports Phys Ther Source Type: research

Falls Among Patients Who Had Elective Orthopedic Surgery: A Decade of Experience From a Musculoskeletal Specialty Hospital.
CONCLUSION: Falls are avoidable events, which are poorly described among orthopedic patients having elective procedures. This large series identifies hip replacement patients as being at almost four-fold risk of having a serious adverse event after falling. However, as this is a retrospective study, larger prospective trials are needed to confirm results, and to inform prevention strategies.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4349. PMID: 23321996 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Mandl LA, Lyman S, Quinlan P, Bailey T, Katz J, Magid SK Tags: J Orthop Sports Phys Ther Source Type: research

Asymmetries in Functional Hop Tests, Lower Extremity Kinematics and Isokinetic Strength Persist 6-9 Months Following ACL Reconstruction.
CONCLUSION: Patients following ACLR demonstrate functional hop and isokinetic knee extension deficits as well as kinematic differences during the propulsion and landing phases of the hop tests at 6-9 months after surgery.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.3967. PMID: 23322072 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Xergia SA, Pappas E, Zampeli F, Georgiou S, Georgoulis AD Tags: J Orthop Sports Phys Ther Source Type: research

Risk Factors for Persistent Problems Following Acute Whiplash Injury: Update of a Systematic Review and Meta-Analysis.
CONCLUSIONS: This review identified 2 additional prognostic factors and refined the estimates of 7 previously identified factors, bringing the total number of significant predictors across the two reviews to 12. These factors can be easily identified in a clinical setting to provide estimates of prognosis following whiplash. LEVEL OF EVIDENCE: Prognosis, level 1a.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4507. PMID: 23322093 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Walton DM, Macdermid JC, Giorgianni AA, Mascarenhas JC, West SC, Zammit CA Tags: J Orthop Sports Phys Ther Source Type: research

The Effect of Lift Teams on Kinematics and Muscle Activity of the Upper Extremity and Trunk.
CONCLUSION: Working in lift teams may be a beneficial intervention for reducing trunk flexion and lumbar paraspinal activity when bricklayers work at heights between the knees and waist, but lift teams are not recommended at higher working heights.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4249. PMID: 23321695 [PubMed - as supplied by publisher]
Source: Health Physics - January 14, 2013 Category: Physics Authors: Anton D, Mizner RL, Hess JA Tags: J Orthop Sports Phys Ther Source Type: research

Abdominal Pain in Physical Therapy Practice: 3 Patient Cases.
This report describes the management of 3 adults with primary complaints of abdominal pain referred for physical therapy evaluation and treatment. DIAGNOSIS: Two of the patients, with secondary symptoms of hip and/or low back pain, had previously undergone extensive medical testing for their chronic abdominal pain without a definitive diagnosis having been determined. A physical therapy evaluation was conducted and treatment, including manual physical therapy and exercise, was administered addressing all relative impairments once the physical therapist had determined that the patients' symptoms were of musculoskeletal orig...
Source: Health Physics - January 14, 2013 Category: Physics Authors: Rodeghero JR, Denninger TR, Ross MD Tags: J Orthop Sports Phys Ther Source Type: research

Quantitative assessment of microcirculation and diffusion in the bone marrow of osteoporotic rats using VCT, DCE-MRI, DW-MRI, and histology.
ConclusionChanges in microcirculation but not diffusion in the bone marrow of osteoporotic rats are detected by DCE-MRI and DW-MRI due to vessel rarefication and maturation. PMID: 23319721 [PubMed - as supplied by publisher]
Source: Acta Radiologica - January 14, 2013 Category: Radiology Authors: Liu Y, Cao L, Hillengass J, Delorme S, Schlewitz G, Govindarajan P, Schnettler R, Heiß C, Bäuerle T Tags: Acta Radiol Source Type: research

Corrigendum to “Association of bone turnover markers and arterial stiffness in pre-dialysis chronic kidney disease (CKD)” [Bone 48 (2011) 1127–1132]
M. Nerlander has been re-instated as an author. The correct author line appears above. Also the Acknowledgment is changed to remove the mention of M. Nerlander as he has been re-instated as an author. The rest of the Acknowledgment remains unchanged.
Source: Bone - January 14, 2013 Category: Orthopaedics Authors: P. Manghat, I. Souleimanova, J. Cheung, A.S. Wierzbicki, D.J. Harrington, M.J. Shearer, P. Chowienczyk, I. Fogelman, M. Nerlander, D. Goldsmith, G. Hampson Tags: Corrigenda Source Type: research

Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing
Abstract: Traditional bone mechanical testing techniques require excised bone and destructive sample preparation. Recently, a cyclic-microindentation technique, reference-point indentation (RPI), was described that allows bone to be tested in a clinical setting, permitting the analysis of changes to bone material properties over time. Because this is a new technique, it has not been clear how the measurements generated by RPI are related to the material properties of bone measured by standard techniques. In this paper, we describe our experience with the RPI technique, and correlate the results obtained by RPI with those o...
Source: Bone - January 14, 2013 Category: Orthopaedics Authors: Maxime A. Gallant, Drew M. Brown, Jason M. Organ, Matthew R. Allen, David B. Burr Tags: Original Articles Source Type: research

Chemokine expression is upregulated in chondrocytes in diabetic fracture healing
Abstract: Chemokines are thought to play an important role in several aspects of bone metabolism including the recruitment of leukocytes and the formation of osteoclasts. We investigated the impact of diabetes on chemokine expression in normal and diabetic fracture healing. Fracture of the femur was performed in streptozotocin-induced diabetic and matched normoglycemic control mice. Microarray analysis was carried out and chemokine mRNA levels in vivo were assessed. CCL4 were examined in fracture calluses by immunohistochemistry and the role of TNF in diabetes-enhanced expression was investigated by treatment of animals wi...
Source: Bone - January 14, 2013 Category: Orthopaedics Authors: Jazia Alblowi, Chen Tian, Michelle F. Siqueira, Rayyan A. Kayal, Erin McKenzie, Yugal Behl, Louis Gerstenfeld, Thomas A. Einhorn, Dana T. Graves Tags: Original Articles Source Type: research

Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in posterolateral lumbar spine fusion: complications in the elderly
DiscussionDespite being older and having more comorbidities, elderly patients have similar complication and reoperation rates compared to younger healthier patients undergoing instrumented lumbar decompression fusions with rhBMP-2
Source: Journal of Orthopaedic Surgery and Research - January 14, 2013 Category: Orthopaedics Authors: Martin HoffmannClifford JonesDebra Sietsema Source Type: research

Right ventricular function impaired in children and adolescents with severe idiopathic scoliosis
Conclusions: Patients with severe scoliosis showed a significant lower right ventricular systolic function.
Source: Scoliosis - January 14, 2013 Category: Orthopaedics Authors: Shujuan LiJunlin YangYunquan LiLing ZhuYuese LinXuandi LiZifang HuangHuishen Wang Source Type: research

Obesity & hypertension are determinants of poor hemodynamic control during total joint arthroplasty: a retrospective review
Conclusions: Preoperative hypertension and being overweight/obese increase the likelihood of poor blood pressure control during TJA. Hypertensive and/or obese patients warrant further attention and medical optimization prior to TJA. More work is required to elucidate the relationship between these risk factors and overall outcome.
Source: BMC Musculoskeletal Disorders - January 14, 2013 Category: Orthopaedics Authors: Benedict NwachukwuJamie CollinsEmily NelsonMercedes ConcepcionThomas ThornhillJeffrey Katz Source Type: research

The effect of education and supervised exercise vs. Education alone on the time to total hip replacement in patients with severe hip osteoarthritis. A randomized clinical trial protocol
DiscussionTo our knowledge, this is the first randomized clinical trial comparing a patient education plus supervised exercise program to patient education alone in hip osteoarthritis patients with an indication for surgery on the time to total hip replacement.Trial registration: NCT01697241
Source: BMC Musculoskeletal Disorders - January 14, 2013 Category: Orthopaedics Authors: Carsten JensenEwa RoosPer Kjærsgaard-AndersenSøren Overgaard Source Type: research

Study protocol: the effect of whole body vibration on acute unilateral unstable lateral ankle sprain- a biphasic randomized controlled trial
DiscussionThis is the first trial investigating the effects of WBV in patients with acute soft tissue injury. Inversion ankle sprains often result in ankle instability, which is most likely due to damage of neurological structures. Due to its unique, frequency dependent, influence on various neuromuscular parameters, WBV is a promising treatment method for patients with acute unstable inversion ankle sprains.Trial registration: NCT01702597
Source: BMC Musculoskeletal Disorders - January 14, 2013 Category: Orthopaedics Authors: Sebastian BaumbachMariette FasserHans PolzerMichael SiebMarkus RegauerWolf MutschlerMatthias SchiekerMichael Blauth Source Type: research

Back pain during growth.
Abstract It is wrong to believe that back pain only burdens adults: the yearly incidence during growth ranges from 10-20%, continuously increasing from childhood to adolescence. Rapid growth-related muscular dysbalance and insufficiency, poor physical condition in an increasingly sedentary adolescent community or - vice versa - high level sports activities, account for the most prevalent functional pain syndromes. In contrast to adults the correlation of radiographic findings with pain is high: the younger the patient, the higher the probability to establish a rare morphologic cause such as benign or malignant tumo...
Source: Swiss Medical Weekly - January 13, 2013 Category: Journals (General) Authors: Hasler CC Tags: Swiss Med Wkly Source Type: research

Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures
Yamato & Takeshi Murata In various cellular membrane systems, vacuolar ATPases (V-ATPases) function as proton pumps, which are involved in many processes such as bone resorption and cancer metastasis, and these membrane proteins represent attractive drug targets for osteoporosis and cancer. The hydrophilic V1 portion is known as a rotary motor, in which a central axis DF complex rotates inside a hexagonally arranged catalytic A3B3 complex using ATP hydrolysis energy, but the molecular mechanism is not well defined owing to a lack of high-resolution structural information. We previously reported on the in vitro ex...
Source: Nature - January 13, 2013 Category: Research Authors: Satoshi AraiShinya SaijoKano SuzukiKenji MizutaniYoshimi KakinumaYoshiko Ishizuka-KatsuraNoboru OhsawaTakaho TeradaMikako ShirouzuShigeyuki YokoyamaSo IwataIchiro YamatoTakeshi Murata Tags: Letter Source Type: research