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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.
Full supervised learning for osteoporosis diagnosis using micro‐CT images
ABSTRACT Early osteoporosis diagnosis is of important significance for reducing fracture risk. Image analysis provides a new perspective for noninvasive diagnosis in recent years. In this article, we propose a novel method based on machine‐learning method performed on micro‐CT images todiagnose osteoporosis. The aim of this work is to find a way to more effectively and accurately diagnose osteoporosis on which many methods have been proposed and practiced. In this method, in contrast to the previously proposed methods in which features are analyzed individually, several features are combined to build a classifier for d...
Source: Microscopy Research and Technique - January 1, 2013 Category: Laboratory Medicine Authors: Yan Xu, Dianshi Li, Qinlang Chen, Yubo Fan Tags: Research Article Source Type: research
A Swan Song (or a Fanfare): Some Thoughts of an Institute Director After 30 Years of Service
Source: American Journal of Orthopsychiatry - January 1, 2013 Category: Psychiatry Authors: Gary B. Melton Tags: Original Article Source Type: research
Rapamycin increases neuroblastoma xenograft and host stromal derived osteoprotegerin inhibiting osteolytic bone disease in a bone metastasis model
Conclusion: In a xenograft model, increased OPG expression correlated with a delay to pathologic fracture suggesting a potential role for mTOR inhibitors in the treatment of neuroblastoma bone metastases.
Source: Journal of Pediatric Surgery - January 1, 2013 Category: Surgery Authors: Joseph E. Hartwich, W. Shannon Orr, Catherine Y. Ng, Yunyu Spence, Jillian M. McLaughlin, Wayne L. Furman, Lisa M. McGregor, Andrew M. Davidoff Tags: APSA Papers Source Type: research
Online discussion of drug side effects and discontinuation among breast cancer survivors
ConclusionOnline discussion of AI‐related side effects was common and often related to drug switching and discontinuation. Physicians should be aware of these discussions and guide patients to effectively manage side effects of drugs and promote optimal adherence. Copyright © 2013 John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - January 1, 2013 Category: Drugs & Pharmacology Authors: Jun J Mao, Annie Chung, Adrian Benton, Shawndra Hill, Lyle Ungar, Charles E. Leonard, Sean Hennessy, John H. Holmes Tags: Original Report Source Type: research
Radiologic case study.
PMID: 23276329 [PubMed - in process]
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Song AJ, Del Giudice M, Lazarus ML, Lomasney LM, Dux K Tags: Orthopedics Source Type: research
History of the orthopedic screw.
PMID: 23276330 [PubMed - in process]
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Roberts TT, Prummer CM, Papaliodis DN, Uhl RL, Wagner TA Tags: Orthopedics Source Type: research
Novel posterior splinting technique to avoid heel ulcers.
Abstract Heel ulcers are a costly and preventable complication of lower-extremity immobilization, but they still occur with some regularity. A technique using a short leg posterior splint that suspends the heel away from the splint is described. This modification completely removes pressure the heel to prevent decubitus ulcer formation. This technique is simple, inexpensive, and effective. PMID: 23276331 [PubMed - in process]
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Hsu RY, Lareau CR, Born CT Tags: Orthopedics Source Type: research
Comparison of 2 Polyethlene Inserts for a New Cruciate-retaining Total Knee Arthroplasty Prosthesis.
Abstract Cruciate-retaining total knee arthroplasty has had high success rates but does not always have optimal functional outcomes. The purpose of this study was to compare 2 polyethylene inserts of varying constraint that were used in a new cruciate-retaining total knee arthroplasty design to determine whether differences were found in clinical or functional outcomes. The use of the newer cruciate-retaining total knee arthroplasty design showed comparable results with both polyethylene inserts at short-term follow-up. The cruciate-retaining design had a greater than 99% survivorship, although further study is nee...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Mont MA, Costa CR, Naiziri Q, Johnson AJ Tags: Orthopedics Source Type: research
Effect of Deformities Below the Ankle on TKA.
PMID: 23276333 [PubMed - in process]
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Duggal N Tags: Orthopedics Source Type: research
Biologically Enhanced Healing of the Human Rotator Cuff: 8-month Postoperative Histological Evaluation.
Abstract Given the high percentage of persistent rotator cuff defects, investigators have begun exploring techniques that use biologic adjuvants to recreate a biomechanically equivalent layer of connective tissue. To evaluate the efficacy of a mesenchymal stem cell, platelet-rich plasma, and dermal allograft construct, a histological comparison of native rotator cuff tissue and biologically enhanced rotator cuff tissue was performed. The evaluation indicated that this treatment modality in conjunction with an adjusted rehabilitation protocol may successfully recreate a transition zone and restore a synovial lining ...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Protzman NM, Stopyra GA, Hoffman JK Tags: Orthopedics Source Type: research
Suprascapular vascular anomalies as a cause of suprascapular nerve compression.
Abstract The vascular anatomy at the spinoglenoid and suprascapular notches appears to be more variable than previously thought. In patients presenting with signs of suprascapular nerve compression, vascular causes must be considered. Especially when considering percutaneous or arthroscopic treatment, awareness of these entities may help to guide treatment decisions, aid in identification of the anatomy, and prevent unwanted vascular insult. PMID: 23276335 [PubMed - in process]
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Houtz C, McCulloch PC Tags: Orthopedics Source Type: research
Medicolegal cases for spinal epidural hematoma and spinal epidural abscess.
The objective of this retrospective analysis study was to identify risk factors for an adverse outcome for the provider.The LexisNexis Academic legal search database was used to identify a total of 19 cases of spinal epidural hematoma and spinal epidural abscess filed against medical providers. Outcome data on trial verdicts, age, sex, initial site of injury, time to consultation, time to appropriate imaging studies, time to surgery, and whether a rectal examination was performed or not were recorded. The results demonstrated a significant association between time to surgery more than 48 hours and an unfavorable verdict fo...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: French KL, Daniels EW, Ahn UM, Ahn NU Tags: Orthopedics Source Type: research
Hip arthroscopy distraction without the use of a perineal post: prospective study.
Abstract Hip arthroscopy is being used with increasing frequency as the understanding of arthroscopic management of groin pain improves. To access the hip joint arthroscopically, traction must be placed on the leg. In most cases, countertraction is provided with a padded post in the groin. Complications of traction are often attributed to the post and include perineal or pudendal neuropraxias and skin complications.The purpose of this study was to investigate the safety of a traction technique that avoids a perineal post. A supine position is used with the foot in a standard traction boot. The patient is moved down...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Mei-Dan O, McConkey MO, Young DA Tags: Orthopedics Source Type: research
Ceramic Liner Fatigue Fracture: 3-D CT Findings in a Late Recurrent THA Dislocation.
Abstract Dislocation is one of the most common complications of total hip arthroplasty (THA). To the authors' knowledge, late recurrent dislocation of a THA with a ceramic-on-ceramic coupling secondary to fatigue fracture of the ceramic liner has never been described.A 76-year-old woman with right hip osteoarthritis underwent cementless modular THA with a ceramic-on-ceramic coupling. Approximately 10 years postoperatively, she experienced right hip pain with no trauma, which resolved in 14 days. Family members reported that the patient had shown a progressive cognitive and muscular decline in the previous months. S...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Trivellin G, Sandri A, Bizzotto N, Marino MA, Mezzari S, Sambugaro E, Regis D Tags: Orthopedics Source Type: research
Rotational osteoplasty for femoral head fracture with cartilage loss.
This article describes a patient who sustained a femoral head fracture-dislocation with significant damage to the articular cartilage of the weight-bearing portion of his femoral head (A). After anatomic reduction of the fracture, a 2×4-cm osteochondral articular defect existed at the weight-bearing portion of the femoral head (B). The femoral head fragment was rotated such that the superior weight-bearing surface was congruent (C). This created a small gap at the inferior aspect of the femoral head, which was filled using a small corticocancellous graft harvested from the greater trochanter. The femoral head fragment was...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Au B, Jamieson MD, Banerjee R Tags: Orthopedics Source Type: research
Two-stage Arthroplasty for the Treatment of Chronic Osteomyelitis After Routine Arthroscopic Knee Surgery.
Abstract Corynebacterium pseudodiphtheriticum is a normal inhabitant of the upper respiratory tract and is rarely thought of as a true pathogen. Although this microorganism has been associated with respiratory complications, a few case reports have demonstrated its ability to cause orthopedic infections. A recent review of the literature was performed regarding this specific bacteria and its association with bone and joint infection.To the author's knowledge, the current case is the first reported case of chronic osteomyelitis from Corynebacterium pseudodiphtheriticum after arthroscopic knee surgery. Isolation of t...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Moyad TF Tags: Orthopedics Source Type: research
Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Proximal Humeral Epiphysis.
This article presents a case of ES/PNET of the proximal humeral epiphysis in a 12-year-old boy. To the authors' knowledge, this is the first reported case of epiphyseal ES/PNET confirmed with molecular testing. Radiographs of the patient's painful shoulder showed a well-defined lytic lesion within the humeral epiphysis. Magnetic resonance imaging suggested a chondroid tumor with surrounding edema. Based on the imaging characteristics, the patient's age, and the lesion's location, a preliminary diagnosis of chondroblastoma was made. A trochar biopsy of the lesion demonstrated a small, round, blue cell tumor on frozen sectio...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Morris P, Dickman PS, Seidel MJ Tags: Orthopedics Source Type: research
Triceps tendon reconstruction using ipsilateral palmaris longus autograft in unrecognized chronic tears.
This article presents 2 patients with chronic, near complete disruptions of the distal triceps tendon. In both patients, surgical reconstruction of the injured tendon was accomplished using ipsilateral palmaris longus autograft. This technique allows the treating surgeon to harvest the graft from the ipsilateral upper extremity. The palmaris autograft is then used to reconstruct the injured portion of the triceps tendon using a Pulvertaft weave technique through the intact triceps tendon and osseous tunnels within the proximal ulna. This technique allows for easy surgical setup and harvest of autograft tendon and provides ...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Scolaro JA, Blake MH, Huffman GR Tags: Orthopedics Source Type: research
Compartment syndrome of the arm caused by transcatheter angiography or angioplasty.
This article presents 4 cases of compartment syndrome of the anterior arm caused by transcatheter angiography or angioplasty; all patients required surgical treatment and anticoagulation therapy. Following urgent fasciotomy and hemostasis, 1 patient experienced recurrent bleeding and another exhibited delayed complex regional pain syndrome of the forearm. The remaining 2 cases had good outcomes.Because all patients had been prescribed various oral anticoagulants, their compartment syndrome was considered a complication of thrombolytic therapy. In addition, because all patients had a history of multiple arterial diseases, a...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Omori S, Miyake J, Hamada K, Naka N, Araki N, Yoshikawa H Tags: Orthopedics Source Type: research
Exceptional Functional Recovery and Return to High-impact Sports After Van Nes Rotationplasty.
This article describes functional status and return to competitive sport after rotationplasty for a lower-extremity bone sarcoma with 3-year follow-up. Despite a postoperative course complicated by a distal tibial physeal injury and femoral neck stress fracture, the patient recovered fully by 1 year postoperatively. Pain free at rest and with activity and with no loss of function, the patient is a successful athlete, playing basketball and baseball and skiing competitively. The patient used a custom-made prosthesis that likely played a role in his high level of function. The patient's high function is evidenced by a maxima...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Harris JD, Trinh TQ, Scharschmidt TJ, Mayerson JL Tags: Orthopedics Source Type: research
Functional data for the diagnosis of patellofemoral laxity obtained by MRI during quadriceps isometric contraction.
Abstract Patellofemoral instability is related to anatomy. Magnetic resonance imaging (MRI) provides anatomic detail, but spoiled gradient echo (SPGR) imaging during isometric quadriceps contraction provides objective functional data for diagnosing patellofemoral laxity.Knee MRI studies and medical charts of 398 patients were retrospectively reviewed. Two independent blinded observers evaluated the knee MRI studies for patellofemoral morphology and patellar position on axial SPGR images during relaxation and isometric quadriceps contraction for lateral patellar migration. Charts were reviewed for history of patello...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Lomasney LM, Demos TC, Neveu M, Fedors NH, Tonino P, Cheung LW Tags: Orthopedics Source Type: research
Articulating spacers for the treatment of infected total knee arthroplasty: effect of antibiotic combinations and concentrations.
Abstract Performing 2-stage procedures using articulating antibiotic cement spacers to eradicate infection while providing pain relief and maintaining function has become common among many surgeons. Despite the efficacy of antibiotic cement spacers in the treatment of infected total knee arthroplasty, questions remain regarding the dosing of the antibiotic cement.The authors assessed their experience with different antibiotic regimens and concentrations for the eradication of infection. Sixty-nine infected total knee arthroplasties with an average follow up of 31 months (range, 6-70 months) treated with articulatin...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Nettrour JF, Polikandriotis JA, Bernasek TL, Gustke KA, Lyons ST Tags: Orthopedics Source Type: research
Validity and reliability of radiographic knee osteoarthritis measures by arthroplasty surgeons.
Abstract Most orthopedic surgeons do not routinely use radiographic classification systems to grade the extent of joint space narrowing in patients considered for total knee arthroplasty. The authors compared the validity and reliability of radiographic measures of tibiofemoral osteoarthritis by 2 experienced and 2 inexperienced orthopedic surgeons on individuals who subsequently underwent total knee arthroplasty. The Kellgren-Lawrence and the Osteoarthritis Research Society International classification systems were used by all surgeons to score the radiographs in 116 individuals in the Osteoarthritis Initiative, a...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Riddle DL, Jiranek WA, Hull JR Tags: Orthopedics Source Type: research
Deltoid muscle pressures during arthroscopic rotator cuff repair.
Abstract The purpose of this study was to investigate deltoid compartment pressures during arthroscopic rotator cuff repair using modern pressure pumps to achieve visualization.Twelve patients undergoing arthroscopic rotator cuff repairs were monitored for deltoid compartment pressure changes intraoperatively. Pre-, intra-, and postoperative intramuscular pressures were recorded. All patients demonstrated varying degrees of swelling due to fluid extravasation. Swelling was qualified as mild, moderate, or severe by clinical assessment and quantified objectively using a pressure monitor to record deltoid compartment ...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: McBrayer DE, Debelak BP, Fernicola PJ, Tu R, Baker CL Tags: Orthopedics Source Type: research
Comparison of arthroscopic osteochondral substitute grafting and remplissage for engaging hill-sachs lesions.
This study demonstrated a potential advantage of remplissage compared with osteochondral synthetic grafting in patients who experienced recurrent anterior shoulder instability, particularly in shoulders with a large humeral head defect. PMID: 23276350 [PubMed - in process]
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Garcia GH, Park MJ, Baldwin K, Fowler J, Kelly JD, Tjoumakaris FP Tags: Orthopedics Source Type: research
MRI Study of Associated Shoulder Pathology in Patients With Full-thickness Subscapularis Tendon Tears.
The objective of the current study was to evaluate the associated shoulder pathology in patients with full-thickness subscapularis tendon tears using magnetic resonance imaging. Forty-seven magnetic resonance imaging studies taken between 2008 and 2009 with a diagnosis of full-thickness subscapularis tendon tears were reviewed. The size of the subscapularis tendon tear, amount of muscle volume loss, Goutallier grade, biceps tendon pathology, coracohumeral distance, and associated rotator cuff tears were recorded. Statistical analysis was performed. Patients 55 years and older vs those 54 years and younger had an average su...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Li X, Fallon J, Egge N, Curry EJ, Patel K, Owens BD, Busconi BD Tags: Orthopedics Source Type: research
Computer-aided Analysis of Radial Head Morphometry.
Abstract Operative treatment of displaced and comminuted radial head fractures involves internal fixation with plates and screws in cases where reconstruction is possible and replacement with a radial head prosthesis when comminution renders the radial head unreconstructable. The purposes of this study were to evaluate the morphometry of the radial head using a modern technique and to compare the findings with several commercially available radial head prostheses.Computed tomography scans of 30 cadaveric elbows and 3-dimensional reconstructions were used to analyze the morphometry of the proximal radius. Results we...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Puchwein P, Heidari N, Dorr K, Struger L, Pichler W Tags: Orthopedics Source Type: research
Anatomic mapping for surgical reconstruction of the proximal tibiofibular ligaments.
The objectives of the current study were to define specific ligamentous structures that provide stability to the proximal tibiofibular joint, describe easily identifiable and reproducible surgical landmarks to aid in surgical reconstruction, and add to the understanding of the posterolateral structures of the knee previously described by other authors.The proximal tibiofibular joint ligaments were identified in 10 fresh-frozen cadaveric specimens. Average ligament length, width, and thickness and area of the footprints of the tibial and fibular attachments were measured. Distances from the ligament footprints to known anat...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: See A, Bear RR, Owens BD Tags: Orthopedics Source Type: research
Balance 1 Year After TKA: Correlation With Clinical Variables.
The objective of this study was to assess changes in balance among patients with knee osteoarthritis at 1 year after total knee arthroplasty (TKA) surgery and its relationship with clinical variables.This prospective, observational study evaluated 44 patients before and 1 year after TKA. Variables analyzed included age, body mass index, pain, range of motion for both knees, bilateral quadriceps and hamstrings muscle strength, gait velocity, and Knee Society score. Balance and posture control were assessed using the following computerized posturography tests: the weight bearing test, modified Clinical Test of Sensory Intera...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Bascuas I, Tejero M, Monleón S, Boza R, Muniesa JM, Belmonte R Tags: Orthopedics Source Type: research
Platelet-rich Plasma as an Effective Treatment for Proximal Hamstring Injuries.
Abstract Proximal hamstring injuries can be disabling, and several traditional conservative treatments, including physiotherapy and nonsteroidal anti-inflammatory drugs, have been inconsistent. Corticosteroid injections have demonstrated success but can adversely affect local tissues. Platelet-rich plasma (PRP) has emerged as a safe, effective treatment for several orthopedic pathologies. The authors propose a PRP injection at the muscle origin as a novel treatment for proximal hamstring injuries.A retrospective review yielded 15 patients with 17 proximal hamstring injuries. Twelve injuries failed traditional conse...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Wetzel RJ, Patel RM, Terry MA Tags: Orthopedics Source Type: research
Surgical Results of Zones I and II Fifth Metatarsal Base Fractures Using Hook Plates.
Abstract The purpose of this study was to evaluate the results of surgical treatment of fifth metatarsal base fractures using a mini-hook plate. Seventeen patients with Lawrence classification zones I (n=6) and II (n=11) fifth metatarsal base fractures with an initial fracture displacement more than 2 mm and a small (less than 2 mm) comminuted avulsion fragment were included in the study. Patients treated using a mini-hook plate fixation method were prospectively evaluated. A mini-hook tubular plate was designed so that the last hole functioned as a hook for the application of compression force, grasping of comminu...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Choi JH, Lee KT, Lee YK, Lee JY, Kim HR Tags: Orthopedics Source Type: research
MRI Reliability in Classifying Thoracolumbar Fractures According to AO Classification.
Abstract The vertebral fracture patterns of AO classification have been established historically via radiograph and computed tomography analysis, achieving modest reproducibility values. The authors hypothesize that magnetic resonance imaging may improve reliability because it better indicates posterior ligamentous complex damage. They conducted a retrospective analysis of a prospective recruited cohort of patients using radiographs and magnetic resonance images with fat saturation sequences to classify 37 traumatic vertebral fractures. Five spine surgeons, 2 orthopedic residents, 2 musculoskeletal radiologists, an...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Salgado A, Pizones J, Sánchez-Mariscal F, Alvarez P, Zúñiga L, Izquierdo E Tags: Orthopedics Source Type: research
Modified Plate-only Open-door Laminoplasty Versus Laminectomy and Fusion for the Treatment of Cervical Stenotic Myelopathy.
Abstract The purpose of this study was to compare modified plate-only laminoplasty and laminectomy and fusion to confirm which of the 2 surgical modalities could achieve a better decompression outcome and whether a significant difference was found in postoperative complications. Clinical data were retrospectively reviewed for 141 patients with cervical stenotic myelopathy who underwent plate-only laminoplasty and laminectomy and fusion between November 2007 and June 2010. The extent of decompression was assessed by measuring the cross-sectional area of the dural sac and the distance of spinal cord drift at the 3 mo...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Yang L, Gu Y, Shi J, Gao R, Liu Y, Li J, Yuan W Tags: Orthopedics Source Type: research
Artificial Disk Replacement Combined With Midlevel ACDF Versus Multilevel Fusion for Cervical Disk Disease Involving 3 Levels.
Abstract The optimal surgical approach for cervical disk disease remains a matter of debate, especially for multilevel disease. The purpose of this study was to compare the results of 2 surgical strategies for cervical disk disease involving 3 levels: hybrid constructs, artificial disk replacement combined with midlevel anterior cervical diskectomy and fusion (ACDF), and 3-level ACDF. The authors prospectively compared patients who had cervical disk disease involving 3 levels that was treated with hybrid constructs or with 3-level ACDF. Patients were asked to use the Neck Disability Index (NDI) to grade their pain ...
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Kang L, Lin D, Ding Z, Liang B, Lian K Tags: Orthopedics Source Type: research
New clinical classification system for atlantoaxial dislocation.
This article proposes a new classification of atlantoaxial dislocation indicating the severity and difficulty in reduction of the atlantoaxial joint. The classification system assists with decision making regarding therapeutic options. Transoral atlantoaxial reduction plate fixation and posterior atlantoaxial screw-rod fixation are commonly performed for atlantoaxial dislocation. PMID: 23276360 [PubMed - in process]
Source: Orthopedics - January 1, 2013 Category: Orthopaedics Authors: Xu J, Yin Q, Xia H, Wu Z, Ma X, Zhang K, Wang Z, Yang J, Ai F, Wang J, Liu J, Mai X Tags: Orthopedics Source Type: research
Open reduction of nasal bone fractures through an intercartilaginous incision.
Conclusion: Open reduction through an intercartilaginous incision was useful for treating delayed-diagnosed nasal bone fractures because it resulted in a successful outcome with minimal complications. Objectives: Nasal bone fractures are generally managed with closed reduction, which is usually inadequate and results in airway obstruction with a delayed diagnosis of nasal bone fracture when bone healing and fibrotic adhesions around the bone fragment have progressed. This study investigated the surgical outcome of open reduction through an intercartilaginous incision for delayed-diagnosis nasal bone fractures. Methods: The...
Source: Acta Oto-Laryngologica - January 1, 2013 Category: ENT & OMF Authors: Kim JH, Lee JH, Hong SM, Park CH Tags: Acta Otolaryngol Source Type: research
LRP5 and LRP6 in development and disease.
Abstract Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are highly homologous proteins with key functions in canonical Wnt signaling. Alterations in the genes encoding these receptors or their interacting proteins are linked to human diseases, and as such they have been a major focus of drug development efforts to treat several human conditions including osteoporosis, cancer, and metabolic disease. Here, we discuss the links between alterations in LRP5/6 and disease, proteins that interact with them, and insights gained into their function from mouse models. We also highlight current drug development re...
Source: Trends in Endocrinology and Metabolism: TEM - January 1, 2013 Category: Endocrinology Authors: Joiner DM, Ke J, Zhong Z, Xu HE, Williams BO Tags: Trends Endocrinol Metab Source Type: research
Significant Rate of Misuse of the Hare Traction Splint for Children with Femoral Shaft Fractures
Femoral shaft fractures are the most common reason for admission to children's hospitals after pediatric orthopedic trauma. Various interventions may be afforded children according to age-specific guidelines, but all children should receive appropriate prehospital care. In an attempt to minimize pain and additional tissue damage, femoral fractures need to be properly splinted during the initial phases of resuscitation. A time-honored splinting device used for this purpose is the Hare traction splint (Dyna Med, Ipswich, MA). Introduced in 1969 by Glenn Hare, the Hare traction splint was designed to improve on the existing t...
Source: Journal of Emergency Nursing: JEN - January 1, 2013 Category: Nursing Authors: Margot C. Daugherty, Charles T. Mehlman, Suzanne Moody, Tom LeMaster, Richard A. Falcone Tags: Trauma Notebook Source Type: research
First evidence of a polygenic susceptibility to pain in a pediatric cohort.
CONCLUSIONS: ABCB1 and OPRM genotypes are associated with clinically meaningful pain variability, whereas NTRK1 and COMT are linked to subclinical effects. This first but small cohort study provides clues to further explore the genetic foundations of pediatric pain. PMID: 23223113 [PubMed - in process]
Source: Anesthesia and Analgesia - January 1, 2013 Category: Anesthesiology Authors: Mamie C, Rebsamen MC, Morris MA, Morabia A Tags: Anesth Analg Source Type: research
Abstract Fibrous dysplasia is an uncommon bone disease. The diagnosis is usually not difficult, given the symptoms, radiology, and histology. The gene involved is the α subunit of the G-protein receptor. Recent innovation in molecular pathology has helped us understand the mechanism of disease pathogenesis. The treatment of fibrous dysplasia is limited to maintenance of maximum bone density. Surgical reinforcement is used to treat bowing deformities and fractures as they occur. Malignant transformation of fibrous dysplasia is rare. Currently, there is no therapy for preventing the disease from advancing or for mal...
Source: Archives of Pathology and Laboratory Medicine - January 1, 2013 Category: Laboratory Medicine Authors: Riddle ND, Bui MM Tags: Arch Pathol Lab Med Source Type: research
Determination and Communication of Critical Findings in Neuroradiology
Conclusions: Clinician-approved and neuroradiologist-approved standardized sets of critical findings can facilitate the communication of important results without “overcalling” and decreasing efficiency. Physician judgment of what constitutes a critical finding supersedes any such list, as clinical scenarios are highly variable from patient to patient. Critical findings lists require intermittent revision to reflect practice patterns and changing incidence of disease. Such a review can constitute a practice quality improvement initiative.
Source: Journal of the American College of Radiology : JACR - January 1, 2013 Category: Radiology Authors: Stacey A. Trotter, Lukasz S. Babiarz, Valentina G. Viertel, Paul Nagy, Jonathan S. Lewin, David M. Yousem Tags: Original Articles Source Type: research
Comparison of the efficacy of ramosetron and ondansetron in the prophylaxis of postoperative vomiting in children receiving fentanyl by patient‐controlled analgesia after orthopedic surgery: a randomized controlled trial
ConclusionRamosetron was more effective during the first 24‐h period after surgery than ondansetron in children using fentanyl patient‐controlled analgesia after general anesthesia.
Source: Pediatric Anesthesia - January 1, 2013 Category: Anesthesiology Authors: Yong‐Hee Park, Young‐Eun Jang, Hyo‐Jin Byon, Jin‐Tae Kim, Hee‐Soo Kim Tags: Original Article Source Type: research
Suggested Guidelines for the Practice of Arthroscopic Surgery
This statement was prepared by the Committee on Ethics and Standards and the Board of Directors of the Arthroscopy Association of North America. The decision to grant and renew privileges in diagnostic arthroscopy and or arthroscopic surgery is typically made by individual hospitals with input from medical staff committees and appropriate department chairpersons, in accordance with individual hospital and medical staff bylaws, rules and regulations. In situations where arthroscopic surgical privileges are requested, a Board Certified orthopedic surgeon or equivalent specialist, with considerable experience in the field of...
Source: Arthroscopy - January 1, 2013 Category: Surgery Tags: Frontmatter Source Type: research
Instructions for Authors
Arthroscopy: The Journal of Arthroscopic and Related Surgery provides readers with current information by publishing the best papers on clinical and basic research, review articles, technical notes, case reports, and editorials about the latest developments in arthroscopic surgery and orthopaedic sports surgery. All articles are subject to peer review. Letters to the Editor and comments on the Journal's content or policies are always welcome.
Source: Arthroscopy - January 1, 2013 Category: Surgery Tags: Frontmatter Source Type: research
The Arthroscopy Association of North America 2013 Master's Experience Courses will be held at the Orthopaedic Learning Center, Rosemont, Illinois: Janary 17-20 (resident), January 25-27 (shoulder), February 14-17 (resident), February 22-24 (hip), March 8-10 (shoulder), April 12-13 (PFF knee), May 18-19 (wrist/elbow), June 7-9 (knee ligament), June 28-30 (hip), July 19-21 (hip), August 23-25 (SOMOS knee), September 20-22 (shoulder), September 28-29 (foot/ankle), October 18-20 (knee cartilage), October 24-27 (resident). For more information, visit www.aana.org
Source: Arthroscopy - January 1, 2013 Category: Surgery Source Type: research
Screening Examination of Premature Infants for Retinopathy of Prematurity
This statement revises a previous statement on screening of preterm infants for retinopathy of prematurity (ROP) that was published in 2006. ROP is a pathologic process that occurs only in immature retinal tissue and can progress to a tractional retinal detachment, which can result in functional or complete blindness. Use of peripheral retinal ablative therapy by using laser photocoagulation for nearly 2 decades has resulted in a high probability of markedly decreasing the incidence of this poor visual outcome, but the sequential nature of ROP creates a requirement that at-risk preterm infants be examined at proper times a...
Source: PEDIATRICS - January 1, 2013 Category: Pediatrics Authors: AMERICAN ACADEMY OF PEDIATRICS Section on Ophthalmology, AMERICAN ACADEMY OF OPHTHALMOLOGY, AMERICAN ASSOCIATION FOR PEDIATRIC OPHTHALMOLOGY AND STRABISMUS, AMERICAN ASSOCIATION OF CERTIFIED ORTHOPTISTS Tags: Ophthalmology From the American Academy of Pediatrics Source Type: research
High-tech waterproof cast maker Exos Medical is sold
Exos Corp., which makes a waterproof alternative to the common cast, has been sold to a subsidiary of its sole distributor, DJO Global Inc., for an undisclosed amount. Vista, Calif.-based DJO has had an exclusive distribution deal with Exos since October 2011. Launched in 2008 by Fariborz Boor Boor, Arden Hills-based Exos develops technology aimed at replacing plaster casting and splinting for broken bones and factures. Among its advantages over a traditional cast, it can be worn in water and an…
Source: bizjournals.com Health Care:Hospitals headlines - December 31, 2012 Category: Hospital Management Authors: Katharine Grayson Source Type: research
Are external knee load and EMG measures accurate indicators of internal knee contact forces during gait?
Abstract Mechanical loading is believed to be a critical factor in the development and treatment of knee osteoarthritis. However, the contact forces to which the knee articular surfaces are subjected during daily activities cannot be measured clinically. Thus, the ability to predict internal knee contact forces accurately using external measures (i.e., external knee loads and muscle electromyographic [EMG] signals) would be clinically valuable. We quantified how well external knee load and EMG measures predict internal knee contact forces during gait. A single subject with a force‐measuring tibial prosthesis and post‐o...
Source: Journal of Orthopaedic Research - December 31, 2012 Category: Orthopaedics Authors: Andrew J. Meyer, Darryl D. D'Lima, Thor F. Besier, David G. Lloyd, Clifford W. Colwell, Benjamin J. Fregly Tags: Research Article Source Type: research
Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast.
In conclusion, treatment with H(2) alleviates TNFα-induced cell injury in osteoblast through abating oxidative stress, preserving mitochondrial function, suppressing inflammation, and enhancing NO bioavailability. PMID: 23212446 [PubMed - in process]
Source: Molecular and Cellular Biochemistry - December 31, 2012 Category: Biochemistry Authors: Cai WW, Zhang MH, Yu YS, Cai JH Tags: Mol Cell Biochem Source Type: research