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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Pseudomorbidity in iliac crest bone graft harvesting: the rise of rhBMP-2 in short-segment posterior lumbar fusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, it is clear that the autologous technique has serious and frequent problems. The other two studies in this issue look at the most common cited complication associated with posterior iliac crest bone graft (ICBG) harvesting, pain. (Source: The Spine Journal)
Source: The Spine Journal - October 21, 2009 Category: Orthopaedics Authors: Eugene J. Carragee, Christopher M. Bono, Gaetano J. Scuderi Tags: Editorial Source Type: journals

Early Switch From IV To Oral Meds Is Effective For Children With Acute Bone InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
When treating children for acute osteomyelitis--a bacterial bone infection--an early changeover from intravenous (IV) antibiotic delivery to oral antibiotics is just as effective as continuing the IV therapy, according to pediatric researchers. In addition, the oral drugs are more convenient for children and families, and avoid a major drawback of IV use: increased risk of complications from using central catheters, such as infections or breaks in the catheter. (Source: Bones / Orthopaedics News From Medical News Today)
Source: Bones / Orthopaedics News From Medical News Today - February 13, 2009 Category: Orthopaedics Tags: Bones / Orthopaedics Source Type: news

Targanta Presents First Data Demonstrating In Vitro Activity And In Vivo Efficacy Of Prodrugs In Osteomyelitis ModelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Targanta Therapeutics Corporation released detailed data from two studies highlighting the in vitro activity and in vivo efficacy of its proprietary prodrugs in osteomyelitis models. Results are being presented today at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) taking place in Chicago, IL and represent the first data sets from this proprietary platform. [click link for full article] (Source: Bones / Orthopaedics News From Medical News Today)
Source: Bones / Orthopaedics News From Medical News Today - September 20, 2007 Category: Orthopaedics Source Type: news

Degenerative changes of the deltoid muscle have impact on clinical outcome after reversed total shoulder arthroplastyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These data show that degeneration of the deltoid muscle is of impact for clinical outcome. Although other factors like disuse or pain as a reason for muscular changes cannot be fully excluded, this degeneration might occur after time due to biomechanical changes after reversed arthroplasty. However, prospective studies with longer follow-up periods and repetitive assessment of muscle quality are necessary to further support these results. Content Type Journal ArticleCategory Orthopaedic SurgeryDOI 10.1007/s00402-009-1001-yAuthors Stefan H. Greiner, Charité-Universitätsmedizin Berlin Dep...
Source: Archives of Orthopaedic and Trauma Surgery - November 6, 2009 Category: Orthopaedics Tags: Archives of Orthopaedic and Trauma Surgery Source Type: journals

Extremity soft tissue sarcomas presented as hematomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We suggest that an STS masquerading as hematoma should be suspected when the mechanism and the energy of the trauma do not justify the clinically detected severity of the injury, or the lesion does not follow the expected clinical course of resolution after initial conservative management. Bleeding predisposition does not exclude malignancy. The evacuation of hematomas should include pathologic examination of tissue. Prognosis is dismal due to early metastatic disease. Content Type Journal ArticleCategory Orthopaedic SurgeryDOI 10.1007/s00402-009-0987-5Authors Vasileios A. Kontogeorgakos, ...
Source: Archives of Orthopaedic and Trauma Surgery - October 16, 2009 Category: Orthopaedics Tags: Archives of Orthopaedic and Trauma Surgery Source Type: journals

[Marjolin's ulcer : Malignant transformation of a crural ulcer due to posttraumatic chronic osteomyelitis.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on the case of an 81-year-old female patient who developed a squamous cell carcinoma in a long-lasting therapy-resistant crural ulcer of the lower leg due to posttraumatic chronic osteomyelitis. Eventually the lower leg had to be amputated because of massive destruction of soft tissue and the tibia bone. Based on the desolate wound conditions plastic reconstruction by a pivoted muscle flap and surgical covering with mesh graft plastic was also necessary.The amputation stump had completely healed 6 months after surgery and the patient is fitted with an artificial limb ensuring independent mobility even outside the...
Source: Der Unfallchirurg - October 28, 2009 Category: Orthopaedics Authors: Bula P, Bula-Sternberg J, Wollina U, Haroske G, Bonnaire F Tags: Unfallchirurg Source Type: journals

Caffeine-potentiated chemotherapy for metastatic osteosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Caffeine-potentiated chemotherapy prolonged survival of patients who had osteosarcoma with pulmonary metastasis. Especially, patients with pulmonary metastasis identified after completion of treatment or with a solitary pulmonary nodule had good prognoses. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00776-009-1372-5Authors Hiroaki Kimura, Kanazawa University Department of Orthopaedic Surgery, Graduate School of Medical Science 13-1 Takaramachi Kanazawa, Ishikawa 920-8641 JapanHiroyuki Tsuchiya, Kanazawa University Department of Orthopaedic Surgery, Graduate School of M...
Source: Journal of Orthopaedic Science - October 3, 2009 Category: Orthopaedics Tags: Journal of Orthopaedic Science Source Type: journals

BMD healthy among testicular cancer survivorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Testicular cancer survivors do not have an increased risk for osteoporosis, suggest long-term UK study findings. (Source: MedWire News - Bone Health)
Source: MedWire News - Bone Health - August 20, 2009 Category: Orthopaedics Source Type: news

Complete denture fractures: A clinical studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Naik Amit VThe Journal of Indian Prosthodontic Society 2009 9(3):148-150The main purpose of the study was to determine the causes for the fracture of complete dentures of patients reporting to the Department of Prosthodontics, Teerthanker Mahaveer Dental College, Moradabad, Uttar Pradesh, India. Data collected from 200 patients reported for repair of their complete dentures. Data was collected from patients, aged between 30 to 80 years (mean 55 plus/minus 25 years), from both the genders. Investigations were done on factors causing the fracture. After the analysis it was observed that the ratio of fracture of upper to lowe...
Source: The Journal of Indian Prosthodontic Society - October 14, 2009 Category: Orthopaedics Authors: Naik Amit V Source Type: journals

Financial Analysis of Methicillin-Resistant Staphylococcus Aureus in a High School WrestlerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This case study is an informative look into MRSA in school athletic settings and just how much money can be saved with increased awareness, prevention, and education. Pediatric Nursing (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - September 23, 2009 Category: Orthopaedics Tags: Nursing Source Type: info

Skeletal metastasis from sarcoma: a report of three casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In the present report, we describe the very rare occurrence of soft tissue metastases from sarcoma at four sites in three patients, focusing on the clinical course and radiological features. All soft tissue masses occurred as a result of disseminated metastases from malignant sarcomas. The initial symptoms presented as painful masses. Magnetic resonance imaging demonstrated a non-specific appearance for the skeletal metastases derived from the sarcomas, corresponding to the signal of the primary lesion. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00590-009-0568-xAuthors Manabu ...
Source: European Journal of Orthopaedic Surgery & Traumatology - October 21, 2009 Category: Orthopaedics Tags: European Journal of Orthopaedic Surgery & Traumatology Source Type: journals

Biological reconstruction after resection of bone tumours around the knee: long-term follow-up.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reviewed 25 patients who had undergone resection of a primary bone sarcoma which extended to within 5 cm of the knee with reconstruction by a combination of a free vascularised fibular graft and a massive allograft bone shell. The distal femur was affected in four patients and the proximal tibia in 21. Their mean age at the time of operation was 19.7 years (5 to 52) and the mean follow-up period 140 months (28 to 213). Three vascularised transfers failed. The mean time to union of the fibula was 5.6 months (3 to 10) and of the allograft 19.6 months (10 to 34). Full weight-bearing was allowed at a mean of 21.4 months...
Source: The Journal of Bone and Joint Surgery. British volume - September 30, 2009 Category: Orthopaedics Authors: Abed YY, Beltrami G, Campanacci DA, Innocenti M, Scoccianti G, Capanna R Tags: J Bone Joint Surg Br Source Type: journals

Extracellular ATP activates MAP kinase cascades and increases intestinal Caco-2 cell proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the role of ATP in the activation of the MAP kinases (MAPKs) ERK1/2, JNK1/2, and p38 and their involvement in the modulation of transcription factors and proliferation of human colon cancer Caco-2 cells. ATP induces the phosphorylation of MAPKs in a time- and dose-dependent manner. Moreover, UTP and ATPgS but not ADP or ADPβS increased phosphorylation of MAPKs, indicating the involvement of, at least, P2Y2/P2Y4 purinergic receptor subtypes. RT–PCR studies and PCR product sequencing supported the expression of P2Y2 and P2Y4 receptors in this cell line. Spectrofluorimetric measurements showed that cell stimula...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: N. Buzzi, P. Scodelaro Bilbao, R. Boland, A. Russo de Boland Source Type: journals

Strontium ranelate for the treatment of osteoporosis: Starting at which age? Two clinical casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Strontium ranelate has emerged in the last few years as a first-line treatment for postmenopausal and senile osteoporosis. Its dual mechanism of action, which combines osteoblastic stimulation and osteoclastic inhibition (anabolic and antirresorptive at the same time), makes it an important element in the therapeutic armamentarium for osteoporosis. There is no published information about its use in young patients with osteopenia. We herein show the experience in two patients with secondary osteoporosis: a young male (aged 27 years) with hypopituitarism who persisted osteoporotic after replacement with testosterone and a p...
Source: Bone - October 29, 2009 Category: Orthopaedics Authors: J. Chiarpenello, A. Sánchez Source Type: journals

Normochromic normocytic anemia in a postmenopausal woman with severe osteoporosis treated with intermittent parathyroid hormoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Intermittent exogenous parathyroid hormone (PTH) is a potent osteoanabolic agent used for the treatment of severe osteoporosis. Two molecules of recombinant PTH are commercially available: the full-length PTH (PTH 1–84) and teriparatide (PTH 1–34). We present the first report of PTH-induced mild, asymptomatic, normochromic normocytic anemia in a postmenopausal woman treated sequentially with PTH 1–84 and PTH 1–34. Anemia was more pronounced with PTH 1–84 compared to PTH 1–34 and was reversed with each regimen discontinuation. We suggest monitoring of hematocrit and hemoglobin in PTH-trea...
Source: Journal of Bone and Mineral Metabolism - July 6, 2009 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: journals

Self-reported frailty predicts calcaneal BMD in elderlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A self-reported measure of frailty may make it easier to identify individuals at risk for osteoporosis than traditional measures, US researchers suggest. (Source: MedWire News - Bone Health)
Source: MedWire News - Bone Health - October 28, 2009 Category: Orthopaedics Source Type: news

Type 2 diabetes features reduce vertebral fracture riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Men with visceral fat and women with insulin resistance may have a reduced risk for vertebral fracture, Japanese study findings show. (Source: MedWire News - Bone Health)
Source: MedWire News - Bone Health - July 15, 2009 Category: Orthopaedics Source Type: news

Muscle activity unaltered by jaw osteoporosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Osteoporosis of the jaw does not significantly alter muscle activity when chewing, suggest the results of an electromyographic study. (Source: MedWire News - Bone Health)
Source: MedWire News - Bone Health - November 12, 2009 Category: Orthopaedics Source Type: news

QUS combined with BMD improves fracture risk predictionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The predictive power of fracture risk models based on clinical factors and bone mineral density may be improved by the inclusion of a quantitative ultrasound measurement, report UK researchers. (Source: MedWire News - Bone Health)
Source: MedWire News - Bone Health - July 31, 2009 Category: Orthopaedics Source Type: news

FRAX tool could reduce osteoporosis undertreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many patients miss out on osteoporosis treatment, say US researchers who believe that the World Health Organization fracture risk assessment tool could identify vulnerable individuals. (Source: MedWire News - Bone Health)
Source: MedWire News - Bone Health - July 1, 2009 Category: Orthopaedics Source Type: news