Parasitology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
19704 records returned
Understanding metal doping for organic electron transport layers
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Alexander Mityashin, David Cheyns, Barry P. Rand, and Paul Heremans This work concerns the physical mechanisms of metal n-doping in charge transport layers for optoelectronic devices, for which the doping level is constrained by transparency requirements so as to avoid parasitic absorption. Comparing various metal dopants, we claim that enhanced conductivity at low ... [Appl. Phys. Lett. 100, 053305 (2012)] published Wed Feb 1, 2012. (Source: Applied Physics Letters)
Source: Applied Physics Letters - February 3, 2012 Category: Physics Source Type: research
Mystery bird: dunnock, Prunella modularis | @GrrlScientistEmail this article to a colleague.
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This drab British mystery bird has a colourful sex life that would make America's Tea Partiers faint Hedge accentor, Prunella modularis (protonym, Motacilla modularis), also known as the hedge sparrow, the shuffle-wing, or as the dunnock accentor, the European dunnock or, most famously (especially in Britain), just as the dunnock, photographed in Brereton Heath Local Nature Reserve, Cheshire, UK. Image: Roy Hill, 23 January 2012 (with permission) [velociraptorize].Canon EOS 5D Mark II 135mm f/2L + 1.4 extender As a reminder, here's the original mystery bird image I shared two days ago: Question: This British mystery bird i...
Source: Guardian Unlimited Science - February 3, 2012 Category: Science Authors: GrrlScientist Tags: Science guardian.co.uk Blogposts Source Type: news
Food assimilated by two sympatric populations of the brown planthopper Nilaparvata lugens (Delphacidae) feeding on different host plants contaminates insect DNA detected by RAPD-PCR analysis.Email this article to a colleague.
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Food assimilated by two sympatric populations of the brown planthopper Nilaparvata lugens (Delphacidae) feeding on different host plants contaminates insect DNA detected by RAPD-PCR analysis.
Genet Mol Res. 2012;11(1):30-41
Authors: Latif MA, Omar MY, Tan SG, Siraj SS, Ali ME, Rafii MY
Abstract
Contamination of insect DNA for RAPD-PCR analysis can be a problem because many primers are non-specific and DNA from parasites or gut contents may be simultaneously extracted along with that of the insect. We measured the quantity of food ingested and assimilated by two sympatric populations of brown planthopper (BP...
Source: Genetics and Molecular Research - February 3, 2012 Category: Genetics & Stem Cells Authors: Latif MA, Omar MY, Tan SG, Siraj SS, Ali ME, Rafii MY Tags: Genet Mol Res Source Type: research
Malaria Deaths Grossly UnderestimatedEmail this article to a colleague.
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A new analysis of malaria mortality published in The Lancet this week suggests deaths to the parasitic disease worldwide have been grossly underestimated, especially in adults. If confirmed, the study has huge implications for how large amounts of charity money are spent in controlling the disease. However, the study also finds that thanks to improved prevention and treatment, such as anti-malaria drugs and insecticide-treated bed nets, deaths to malaria are falling rapidly... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Tropical Diseases Source Type: news
Parasites or not? Transposable elements in fruit fliesEmail this article to a colleague.
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(University of Veterinary Medicine -- Vienna) The problem of parasitism occurs at all levels right down to the DNA scale. Genomes may contain up to 80 percent "foreign" DNA but details of the mechanisms by which this enters the host genome and how hosts attempt to combat its spread are still the subject of conjecture. Important new information comes from the group of Christian Schlötterer at the University of Veterinary Medicine, Vienna. The findings are published in the prestigious journal PLoS Genetics. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 3, 2012 Category: Biology Source Type: news
Malaria kills twice as many people as previously thought, research findsEmail this article to a colleague.
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Malaria kills 1.2 million people every year, a finding that has implications for global efforts to eliminate the diseaseMalaria kills twice as many people every year as formerly believed, taking 1.2 million lives and causing the deaths not only of babies but also older children and adults, according to research that overturns decades of assumptions about one of the world's most lethal diseases.The findings from the research, published on Friday, which has reanalysed 30 years of data on the disease using new techniques, will force a rethink of the huge global effort that has been under way to eliminate malaria. That ambitio...
Source: Guardian Unlimited Science - February 2, 2012 Category: Science Authors: Sarah Boseley Tags: Malaria Society Global Fund to Fight Aids, Tuberculosis and Malaria Global development World news Infectious diseases Medical research Science The Guardian Source Type: news
Multifunctional CD4+T cells in patients with American cutaneous leishmaniasisEmail this article to a colleague.
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SummaryLeishmaniasis is a group of important parasitic diseases affecting millions worldwide. To understand more clearly the quality of T helper type 1 (Th1) response stimulated after Leishmania infection, we applied a multiparametric flow cytometry protocol to evaluate multifunctional T cells induced by crude antigen extracts obtained from promastigotes of Leishmania braziliensis (LbAg) and Leishmania amazonensis (LaAg) in peripheral blood mononuclear cells from healed cutaneous leishmaniasis patients. Although no significant difference was detected in the percentage of total interferon (IFN)‐γ‐producing CD4+T cells ...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: A. B. B. MacedoJ. C. Sánchez‐ArcilaA. O. SchubachS. C. F. MendonçaA. Marins‐Dos‐SantosM. de Fatima MadeiraT. GaginiM. I. F. PimentelP. M. De Luca Source Type: research
Copy number variation of individual cattle genomes using next-generation sequencing [RESOURCES]Email this article to a colleague.
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Copy number variations (CNVs) affect a wide range of phenotypic traits; however, CNVs in or near segmental duplication regions are often intractable. Using a read depth approach based on next-generation sequencing, we examined genome-wide copy number differences among five taurine (three Angus, one Holstein and one Hereford) and one indicine (Nelore) cattle. Within mapped chromosomal sequence, we identified 1,265 CNV regions comprising ~55.6 Mbp sequence - 476 of which (~38%) have not previously been reported. We validated this sequence-based CNV call set with aCGH, qPCR and FISH, achieving a validation rate of 82% and a f...
Source: Genome Research - February 2, 2012 Category: Genetics & Stem Cells Authors: Bickhart, D. M., Hou, Y., Schroeder, S. G., Alkan, C., Cardone, M. F., Matukumalli, L. K., Song, J., Schnabel, R. D., Ventura, M., Taylor, J. F., Garcia, J. F., Van Tassell, C. P., Sonstegard, T. S., Eichler, E. E., Liu, G. E. Tags: RESOURCES Source Type: research
Genotyping for cytokine polymorphisms in a Northern Ivory Coast population reveals a high frequency of the heterozygote genotypes for the TNF‐α‐308G/A SNPEmail this article to a colleague.
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SummaryCytokine polymorphisms influence the outcomes of parasitic diseases and vary among populations because of their different evolutionary histories and selective pressures imposed by host–pathogen interactions. In this frame, we investigated the frequencies of TNF‐α (‐308G/A), TGF‐β1 (codon 10C/T, codon 25C/G) and IL‐10 (‐1082A/G) SNPs in 133 individuals from Ouangolodougou, a rural village in Northern Ivory Coast, where malaria and other parasitic diseases are endemic. The SNPs alleles were determined by ARMS‐PCR methodology. Allele frequencies of the SNPs investigated were as follows: IL 10 ‐1082G...
Source: International Journal of Immunogenetics - February 2, 2012 Category: Genetics & Stem Cells Authors: A. SantovitoP. CervellaD. SchleicherovaM. Delpero Source Type: research
Validation of the Rapid Assessment Procedure for Loiasis (RAPLOA) in the Democratic Republic of CongoEmail this article to a colleague.
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This study was designed to validate RAPLOA in two regions in the North East and South West of the Democratic Republic of Congo. In each selected community, 80 people above the age of 15 years were interviewed for a history of eye and parasitologically examined for the presence and intensity of L. loa infection. The results confirmed the findings of the original RAPLOA study and the methodology is recommended for the assessment of loiasis endemicity in areas targeted for ivermectin treatment by lymphatic filariasis and onchocerciasis control programmes. Image: RAPLOA Interview; Field surveyor showing the picture of L. loa i...
Source: BioMed Central - February 2, 2012 Category: Journals (General) Authors: Samuel WanjiDowo O AkotshiMaurice N MutroTepage FloribertTony O UketyPeter J DiggleJan H Remme Source Type: research
Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria-exposed populationEmail this article to a colleague.
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Conclusions:
The current data shows that levels of naturally acquired antigen-specific antibodies, especially in infants and young children, are dependent on the antigenic allele used for measurement. This may be relevant to the interpretation of antibody titre data from measurements against single PfAMA1 alleles, especially in studies involving infants and young children who have experienced fewer infections. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 2, 2012 Category: Infectious Diseases Authors: Kwadwo KusiDaniel DodooSamuel BosomprahMarjolein van der EijkBart FaberClemens KockenEdmond Remarque Source Type: research
Potential new treatment identified for leishmaniasisEmail this article to a colleague.
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(University of Dundee) Researchers at the University of Dundee have identified fexinidazole as a possible, much-needed, new treatment for the parasitic disease visceral leishmaniasis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 2, 2012 Category: Global & Universal Source Type: news
Halophilanema prolata n. gen., n. sp. (Nematoda: Allantonematidae), a parasite of the intertidal bug, Saldula laticollis (Reuter)(Hemiptera: Saldidae) on the Oregon coastEmail this article to a colleague.
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Halophilanema prolata (Nematoda: Allantonematidae) is described from the intertidal bug, Saldula laticollis on the Oregon coast. Infection rates ranged from 0 % to 85% depending on the microhabitat in the intertidal zone. Image: Parasitic female and juvenile stages of Halophilanema prolata removed from the hemocoel of the intertidal bug, Saldula laticollis on the Oregon coast. (Source: Parasites and Vectors)
Source: Parasites and Vectors - February 1, 2012 Category: Microbiology Authors: George Poinar Source Type: research
From red to white urine: a patient`s nightmare with a rather benign outcomeEmail this article to a colleague.
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Conclusions:
This case highlights a rare case of non-parasitic chyluria as a complication of urological work-up for macrohematuria of benign nature. (Source: BMC Nephrology)
Source: BMC Nephrology - February 1, 2012 Category: Urology & Nephrology Authors: Benjamin KnierBetarix Bueschges-SeraphinKarl HilgersKerstin AmannMichael UderKai-Uwe EckardtJohannes Jacobi Source Type: research
Intersexuality in Crustacea: An environmental issue?Email this article to a colleague.
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Abstract
This paper aims to give a historical overview of current understanding about intersexuality in crustaceans, assesses gaps in our knowledge and asks whether it should be an environmental concern. The oldest known cases of intersexuality come from 70 million year old fossil crabs whilst the oldest published case of intersex crustacean stems from a 1730 Royal Society report of a gynandromorph lobster. Many crustacean species are sequential hermaphroditic or simultaneous hermaphrodites. Consequently, there has been confusion as to whether accounts of intersex in the literature are correct. Intersexuality is fa...
Source: Aquatic Toxicology - February 1, 2012 Category: Toxicology Authors: Ford AT Tags: Aquat Toxicol Source Type: research
Association of the level of IFN-{gamma} produced by T cells in response to Mycobacterium tuberculosis-specific antigens with the size of skin test indurations among individuals with latent tuberculosis in a highly tuberculosis-endemic settingEmail this article to a colleague.
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In conclusion, the results of this study could provide indirect evidence for the prognostic use of the QFTGIT assay for progression of Mtb infection, though prospective follow-up studies are needed to provide direct evidence. (Source: International Immunology)
Source: International Immunology - February 1, 2012 Category: Allergy & Immunology Authors: Legesse, M., Ameni, G., Mamo, G., Medhin, G., Bjune, G., Abebe, F. Tags: ORIGINAL RESEARCH PAPERS Source Type: research
Targeting Malaria HotspotsEmail this article to a colleague.
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(Ivanhoe Newswire) – Malaria is a parasite disease that is passed from one human to another by the bite of infected Anopheles mosquitoes. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - February 1, 2012 Category: Consumer Health News Source Type: news
Global Update: Joint Effort Announced Against Tropical DiseasesEmail this article to a colleague.
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Companies, governments and nonprofit organizations are releasing money, access to databases and outreach efforts to counter diseases such as leprosy and guinea worm. (Source: NYT)
Source: NYT - January 31, 2012 Category: American Health Authors: By DONALD G. McNEIL Jr. Tags: Parasites Philanthropy Guinea Worm Disease Medicine and Health World Bank Gates, Bill and Melinda, Foundation Lions Clubs International United Arab Emirates Great Britain Source Type: news
Equine cestodosis: a sero-epidemiological study of Anoplocephala perfoliata infection in EthiopiaEmail this article to a colleague.
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Abstract A 12/13 kDa antigen, tapeworm ELISA test, developed for use in horses, was used to detect parasite-specific serum antibody,
IgG(T), in the serum of donkeys. In a pilot study the 12/13 kDa antigen was tested and proved to detect the antibody, IgG(T),
in donkey sera. Blood samples from 797 donkeys, naturally exposed to cestode infection, from four geographical localities
were collected and sera were prepared and analysed. There was substantial serological evidence that donkeys were potentially
infected with A. perfoliata. A range of ELISA OD values were obtained from the serological assay. O...
Source: Veterinary Research Communications - January 31, 2012 Category: Veterinary Research Tags: Veterinary Research Communications Source Type: research
"Parasitic twin" found in Peru toddler's stomachEmail this article to a colleague.
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Doctors found Isbac Pacunda's would-be twin's bones in his stomach, to remove in surgery this week (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - January 31, 2012 Category: Consumer Health News Source Type: news
Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathwayEmail this article to a colleague.
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Conclusions:
Our reverse genetics data demonstrate that each of the two regulatory PfCK2 subunits is required for completion of the asexual erythrocytic cycle. Our interactome study points to an implication of PfCK2 in many cellular pathways, with chromatin dynamics being identified as a major process regulated by PfCK2. This study paves the way for a kinome-wide interactomics-based approach to elucidate protein kinase function in malaria parasites. (Source: BMC Biology - Latest articles)
Source: BMC Biology - Latest articles - January 31, 2012 Category: Biology Authors: Eeshita DastidarGuillem DayerZoe HollandDominique Dorin-SemblatAurelie ClaesArnaud CheneAmit SharmaRomain HamelinMarc MoniatteJose-Juan Lopez-RubioArtur ScherfChristian Doerig Source Type: research
SMYD3 Promotes Cancer Invasion by Epigenetic Upregulation of the Metalloproteinase MMP-9Email this article to a colleague.
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Upregulation of the matrix metalloproteinase (MMP)–9 plays a central role in tumor progression and metastasis by stimulating cell migration, tumor invasion, and angiogenesis. To gain insights into MMP-9 expression, we investigated its epigenetic control in a reversible model of cancer that is initiated by infection with intracellular Theileria parasites. Gene induction by parasite infection was associated with trimethylation of histone H3K4 (H3K4me3) at the MMP-9 promoter. Notably, we found that the H3K4 methyltransferase SMYD3 was the only histone methyltransferase upregulated upon infection. SMYD3 is overexpressed in m...
Source: Cancer Research - January 31, 2012 Category: Cancer & Oncology Authors: Cock-Rada, A. M., Medjkane, S., Janski, N., Yousfi, N., Perichon, M., Chaussepied, M., Chluba, J., Langsley, G., Weitzman, J. B. Tags: Tumor and Stem Cell Biology Source Type: research
Adoptive Transfer of IL-4Ralpha+ Macrophages is Sufficient to Enhance Eosinophilic Inflammation in a Mouse Model of Allergic Lung InflammationEmail this article to a colleague.
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Conclusions:
These results demonstrate that transfer of IL-4Ralpha+ macrophages is sufficient to enhance TH2-driven allergic inflammation. They further show that stimulation of macrophages through IL-4Ralpha leads to their alternative activation and positive contribution to the TH2-driven allergic inflammatory response in the lung. Since an increase in AAM and their products has been observed in patients with asthma exacerbations, these results suggest that AAM may be targeted to alleviate exacerbations. (Source: BMC Immunology)
Source: BMC Immunology - January 31, 2012 Category: Allergy & Immunology Authors: Andrew FordPreeta DasguptaIrina MikhailenkoElizabeth SmithNancy Noben-TrauthAchsah Keegan Source Type: research
Involvement of TatD nuclease during programmed cell death in the protozoan parasite Trypanosoma bruceiEmail this article to a colleague.
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In this report, we describe the involvement of TatD nuclease during programmed cell death (PCD) in the human protozoan parasite Trypanosoma brucei. T. brucei TatD nuclease showed intrinsic DNase activity, was localized in the cytoplasm and translocated to the nucleus when cells were treated with inducers previously demonstrated to cause PCD in T. brucei. Overexpression of TatD nuclease resulted in elevated PCD and conversely, loss of TatD expression by RNAi conferred significant resistance to the induction of PCD in T. brucei. Co‐immunoprecipitation studies revealed that TatD nuclease interacts with endonucleaseG s...
Source: Molecular Microbiology - January 31, 2012 Category: Microbiology Authors: Sreenivas GannavaramAlain Debrabant Source Type: research
Global Update: Joint Effort Announced Against Tropical DiseasesEmail this article to a colleague.
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Companies, governments and nonprofit organizations are releasing money, access to databases and outreach efforts to counter diseases such as leprosy and guinea worm. (Source: NYT Health)
Source: NYT Health - January 30, 2012 Category: Consumer Health News Authors: By DONALD G. McNEIL Jr. Tags: Parasites Philanthropy Guinea Worm Disease Medicine and Health Source Type: news
Low-Molecular-Mass Antioxidants in ParasitesEmail this article to a colleague.
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Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - January 30, 2012 Category: Research Tags: article Source Type: research
Guinea worm disease will be gone by 2015: Carter CenterEmail this article to a colleague.
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The Carter Center on Monday announced it received $40 million in donations to help fuel its mission to eradicate Guinea worm disease, a debilitating parasite that once plagued millions of people across the developing world. (Source: CTV Health)
Source: CTV Health - January 30, 2012 Category: Consumer Health News Source Type: news
Apicoplast targeting of a T. gondii transmembrane protein requires a cytosolic tyrosine‐based motifEmail this article to a colleague.
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Toxoplasma gondii, like most apicomplexan parasites, possesses an essential relict chloroplast, the apicoplast. Several apicoplast membrane proteins lack the bipartite targeting sequences of luminal proteins. Vesicles bearing these membrane proteins are detected during apicoplast enlargement, but the means of cargo selection remains obscure. We used a combination of deletion mutagenesis, point mutations, and protein chimeras to identify a short motif prior to the first transmembrane domain of the T. gondii apicoplast phosphate transporter 1 (APT1) that is necessary for apicoplast trafficking. Tyrosine 16 was essential for ...
Source: Traffic - January 30, 2012 Category: Research Authors: Amy E. DeRocherAnuradha KarnatakiPashmi VaneyMarilyn Parsons Source Type: research
Ubiquitin Proteasome System and the atypical kinase PfPK7 are involved in melatonin signaling in Plasmodium falciparumEmail this article to a colleague.
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AbstractWe previously reported that melatonin modulates the Plasmodium falciparum erythrocytic cycle by increasing schizont stage population as well as diminishing ring stage population.In addition, the importance of calcium and cAMP in melatonin signaling pathway in P. falciparum was also demonstrated. Nevertheless the molecular effectors of the indoleamine signaling pathway remain elusive. We now demonstrate by real time PCR that melatonin treatment up‐regulates genes related to ubiquitin/proteasome system (UPS) components and that luzindole, a melatonin receptor antagonist, inhibits UPS transcription modulation. We al...
Source: Journal of Pineal Research - January 30, 2012 Category: Research Authors: Fernanda C. KoyamaRamira Y. RibeiroJulio L. GarciaMauro F. AzevedoDebopam ChakrabartiCélia R. S. Garcia Source Type: research
An evolutionary perspective on C‐type lectins in infection and immunityEmail this article to a colleague.
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Host–pathogen interactions have coevolved for many years. On the one hand, the human immune system consists of innate and adaptive immune cells that function to defeat pathogens, and on the other hand, pathogens have coevolved to use the system for their own propagation. C‐type lectins are conserved receptors recognizing carbohydrate structures on viruses, bacteria, parasites, and fungi. C‐type lectins such as DC‐SIGN, langerin, and dectin‐1 are expressed by dendritic cell subsets and macrophages. Pathogen recognition by C‐type lectins triggers signaling pathways that lead to the expression of specific cytokine...
Source: Annals of the New York Academy of Sciences - January 30, 2012 Category: Science Authors: Linda M. van den BergSonja I GringhuisTeunis B.H Geijtenbeek Tags: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Source Type: research
Current concepts of IgE regulation and impact of genetic determinantsEmail this article to a colleague.
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AbstractImmunoglobulin E (IgE) mediated immune responses seem to be directed against parasites and neoplasms but are best known for their involvement in allergies. The IgE network is tightly controlled at different levels as outlined in this review. Genetic determinants were suspected to influence IgE regulation and IgE levels considerably for many years. Linkage and candidate gene studies suggested a number of loci and genes to correlate with total serum IgE levels and recently genome‐wide association studies (GWAS) provided the power to identify genetic determinants for total serum IgE levels: 1q23 (FCER1A), 5q31 (RAD5...
Source: Clinical and Experimental Allergy - January 30, 2012 Category: Allergy & Immunology Authors: Daniel P. PotaczekMichael Kabesch Tags: Invited Review Source Type: research
The 'Neglected Tropical Diseases': now a brand identity; responsibilities, context and promise.Email this article to a colleague.
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No abstract required for an Editorial (Source: Parasites and Vectors)
Source: Parasites and Vectors - January 30, 2012 Category: Microbiology Authors: David Molyneux Source Type: research
Taxonomy of lice and their endosymbiotic bacteria in the post‐genomic eraEmail this article to a colleague.
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AbstractRecent studies of molecular and genomic data from the parasitic lice of birds and mammals, as well as their mutualistic endosymbiotic bacteria, are changing the phylogenetic relationships and taxonomy of these organisms. Phylogenetic studies of lice suggest that vertebrate parasitism arose multiple times from free‐living book and bark lice. Molecular clocks show that the major families of lice arose in the late Mesozoic and radiated in the early Cenozoic following the radiation of mammals and birds. The recent release of the human louse genome has provided new opportunities for research. The genome is being used ...
Source: Clinical Microbiology and Infection - January 30, 2012 Category: Microbiology Authors: Bret M. BoydDavid L. Reed Source Type: research
A promiscuous antitoxin of bacteriophage T4 ensures successful viral replicationEmail this article to a colleague.
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This study is an exciting addition to both the bacteriophage resistance and TA fields, and suggests a greater role for TA system‐based resistance and counter‐resistance in the world's oldest predator‐prey relationship. (Source: Molecular Microbiology)
Source: Molecular Microbiology - January 29, 2012 Category: Microbiology Authors: Francesca L. ShortTim R. BlowerGeorge P. C. Salmond Source Type: research
Surging raccoon numbers could raise infection riskEmail this article to a colleague.
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Canadian doctors are reporting two human infections with raccoon roundworm, a parasite many of the pesky critters carry in their guts and excrete in their poo. (Source: CTV Health)
Source: CTV Health - January 28, 2012 Category: Consumer Health News Source Type: news
Sensilla on the antennal funiculus of the horse stomach bot fly, Gasterophilus nigricornisEmail this article to a colleague.
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Gasterophilus nigricornis (Loew) (Diptera: Oestridae) is one of the most damaging obligate parasites of equids in Kalamaili, Xinjiang, China. The main olfactory organs of this stomach bot fly are paired antennae that bear microscopic sensillar structures. The external morphology of the antennal funiculus and sensilla of male G. nigricornis were studied using stereopic microscopy and scanning electron microscopy. A cross‐sectional view of the funiculus shows it to be triangular, with an anterodorsal surface, a dorsolateral margin and a posteroventral surface. Almost the entire surface of the funiculus is densely covered w...
Source: Medical and Veterinary Entomology - January 28, 2012 Category: Veterinary Research Authors: D. ZHANGQ. K. WANGD. F. HUK. LI Source Type: research
A working life: the geneticistEmail this article to a colleague.
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Joe Rainger might still have been a chef, but for a degree change that took him out of the kitchen and plunged him into a world of DNA researchPeople born with abnormal eyes could – within our lifetime – benefit from replacements that match their own DNA, thanks to research by scientists like Joe Rainger.The 35-year-old geneticist is researching a mutation in human genes that causes microphthalmia (one or both eyes abnormally small), anophthalmia (absence of one or both eyes), and coloboma (a gap in the structure of the eye). The conditions are recessive; which means you need both parents to carry the defective gene fo...
Source: Guardian Unlimited Science - January 27, 2012 Category: Science Authors: Jill Insley Tags: Work & careers Money Genetics Medical research Science The Guardian Features Source Type: news
3D Study Of Vitamins May Help Combat MalariaEmail this article to a colleague.
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A three-dimensional study of how enzymes in the malaria parasite Plasmodium synthesize essential vitamins, could help develop new drugs to combat the disease. Using electron microscopy, a team of scientists from Germany and the UK studied how the enzymes synthesize Vitamin B6, which has already been proposed as a target for new drugs. Dr Ivo Tews, a Lecturer in Structural Biology at the University of Southampton, and colleagues, write about their findings in a paper published online in the journal Structure on 11 January... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 27, 2012 Category: Consumer Health News Tags: Tropical Diseases Source Type: news
Mutation scanning‐based analysis of anisakid larvae from Sillago flindersi from Bass Strait, AustraliaEmail this article to a colleague.
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This study revealed that 92% of the S. flindersi examined were infected with anisakids (n=194), which were represented by seven genotypes. Phylogenetic analyses of the genotypes defined herein, together with reference sequence for Anisakis pegreffii and Hysterothylacium sp. from public databases (i.e. GenBank), revealed the presence of A. pegreffii (n=24), Hysterothylacium larval type IV (n=90) and Hysterothylacium larval type VIII (n=80) in S. flindersi. Thus, the PCR‐coupled mutation scanning approach employed herein is an effective tool for the genetic characterisation of anisakid nematodes for diagnostic and analytic...
Source: Electrophoresis - January 27, 2012 Category: Biochemistry Authors: Abdul JabbarAvalene T. W. KhoonTeo X. HuiBjoern C. SchaeffnerAaron R. JexMatthew J. NolanAndreas LopataRobin B. GasserIan Beveridge Tags: Nucleic Acids Source Type: research
The role of nuclear technologies in the diagnosis and control of livestock diseases—a reviewEmail this article to a colleague.
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Abstract Nuclear and nuclear-related technologies have played an important role in animal health, particularly in relation to disease
diagnosis and characterization of pathogenic organisms. This review focuses primarily on how and where nuclear technologies,
both non-isotopic and isotopic methods, have made their impact in the past and where it might be expected they could have
an impact in the future. The review outlines the extensive use of radiation attenuation in attempts to create vaccines for
a multiplicity of pathogenic organisms and how the technology is being re-examined in the light of recent advan...
Source: Tropical Animal Health and Production - January 27, 2012 Category: Veterinary Research Tags: Tropical Animal Health and Production Source Type: research
Coexistent dermoid cysts of the pouch of the Douglas and ovary resected by laparoscopyEmail this article to a colleague.
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AbstractDermoid cysts of the ovary are one of the most common ovarian neoplasms, but parasitic dermoid cysts as well as coexistent dermoid cysts are unusual. Almost all reports of coexistent dermoid cysts involve the omentum and ovary, but our case involved the pouch of Douglas and ovary. We managed this case by laparoscopy. (Source: Asian Journal of Endoscopic Surgery)
Source: Asian Journal of Endoscopic Surgery - January 27, 2012 Category: Surgery Authors: M TokunagaM SetaM YamadaM NishioK YamamotoY Koyasu Tags: Case Report Source Type: research
Method Discovered By Researchers To Unravel Malaria's Genetic SecretsEmail this article to a colleague.
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The parasite that causes malaria is a genetic outlier, which has prevented scientists from discovering the functions of most of its genes. Researchers at National Jewish Health and Yale University School of Medicine have devised a technique to overcome the genetic oddity of Plasmodium falciparum, the major cause of human malaria. This new approach led them discover a new gene involved in lipid synthesis, and opens the door to further genetic discovery for the entire organism... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 27, 2012 Category: Consumer Health News Tags: Tropical Diseases Source Type: news
Methodology optimizing SAGE library tag-to-gene mapping: application to LeishmaniaEmail this article to a colleague.
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Conclusion:
The developed method optimizes the assignment of SAGE tags in trypanosomatidae genomes as well as in any genome having polycistronic transcription and small intergenic regions. (Source: BMC Research Notes)
Source: BMC Research Notes - January 27, 2012 Category: Research Authors: Sondos SmandiFatma GuerfaliMohamed FarhatKhadija Ben-AissaDhafer LaouiniLamia Guizani-TabbaneKoussay DellagiAlia Benkahla Source Type: research
Haematological parameters, natural regulatory CD4+CD25+FOXP3+ T cells and gammadelta T cells among two sympatric ethnic groups having different susceptibility to malaria in Burkina FasoEmail this article to a colleague.
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Conclusion:
Our findings on regulatory T cell phenotypes suggest an interesting role for immune regulatory mechanisms in response to malaria. The study also suggests that TCRgammadelta + cells might contribute to the protection against malaria in the Fulani ethnic group involving their reported parasite inhibitory activities. (Source: BMC Research Notes)
Source: BMC Research Notes - January 27, 2012 Category: Research Authors: Guillaume SanouRegis TiendrebeogoAndre OuedraogoAmidou DiarraAlphonse OuedraogoJean-Baptiste YaroEsperance OuedraogoFederica VerraCharlotte BehrMarita Troye-BlombergDavid ModianoAmagana DoloMaria TorciaYves TraoreSodiomon SirimaIssa Nebie Source Type: research
Prevalence and risk factors for Giardia duodenalis infection among children: A case study in PortugalEmail this article to a colleague.
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We investigated the prevalence of Giardia duodenalis infection and identified possible associated risk factors in a healthy paediatric population from Portugal. We highlight the high prevalence of G.duodenalis in these children, as well as the parents¿ education level as the main risk factor. Of interest, we also found an association between G. duodenalis and Helicobacter pylori infections. Image: Giardia duodenalis cysts stained by FICT. (Source: Parasites and Vectors)
Source: Parasites and Vectors - January 27, 2012 Category: Microbiology Authors: Claudia JulioAnabela VilaresMonica OleastroIdalina FerreiraSalome GomesLurdes MonteiroBaltazar NunesRogerio TenreiroHelena Angelo Source Type: research
Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone DerivativesEmail this article to a colleague.
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AbstractDihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit important in vitro antimalarial activity (1.0 μM ≤ IC50≤ 5.0 μM) against blood forms of the human malaria parasite Plasmodium falciparum.© 2012 John Wiley & Sons A/S (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - January 27, 2012 Category: Biology Authors: Lucas Lopardi FrancoMauro Vieira de AlmeidaLuiz Francisco Rocha e SilvaPedro Paulo Ribeiro VieiraAdrian Martin PohlitMarcelo Siqueira Valle Source Type: research
Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparumEmail this article to a colleague.
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Orotate phosphoribosyltransferase (OPRT) catalyzes the Mg2+-dependent condensation of orotic acid (OA) with 5-α-d-phosphorylribose 1-diphosphate (PRPP) to yield diphosphate (PPi) and the nucleotide orotidine 5′-monophosphate. OPRT from Plasmodium falciparum produced in Escherichia coli was crystallized by the sitting-drop vapour-diffusion method in complex with OA and PRPP in the presence of Mg2+. The crystal exhibited tetragonal symmetry, belonging to space group P41 or P43, with unit-cell parameters a = b = 49.15, c = 226.94 Å. X-ray diffraction data were collected to 2.5 Å resolution at 100 K using a synchr...
Source: Acta Crystallographica Section F - January 27, 2012 Category: Biochemistry Authors: Takashima, Y.Mizohata, E.Tokuoka, K.Krungkrai, S.R.Kusakari, Y.Konishi, S.Satoh, A.Matsumura, H.Krungkrai, J.Horii, T.Inoue, T. Tags: orotate phosphoribosyltransferase Plasmodium falciparum crystallization communications Source Type: research
Activation of TgNTPDases [Molecular Bases of Disease]Email this article to a colleague.
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The intracellular parasite Toxoplasma gondii produces two nucleoside triphosphate diphosphohydrolases (NTPDase1 and -3). These tetrameric, cysteine-rich enzymes require activation by reductive cleavage of a hitherto unknown disulfide bond. Despite a 97% sequence identity, both isozymes differ largely in their ability to hydrolyze ATP and ADP. Here, we present crystal structures of inactive NTPDase3 as an apo form and in complex with the product AMP to resolutions of 2.0 and 2.2 Å, respectively. We find that the enzyme is present in an open conformation that precludes productive substrate binding and catalysis. The cystein...
Source: Journal of Biological Chemistry - January 27, 2012 Category: Chemistry Authors: Krug, U., Zebisch, M., Krauss, M., Strater, N. Tags: Protein Structure and Folding Source Type: research
[Rare retrovesical tumor manifestation of cystic echinococcosis (Echinococcus granulosus).]Email this article to a colleague.
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Abstract
Unclear pelvic retrovesical intraperitoneal tumors can be caused by cystic echinococcosis. A definitive diagnosis of this disease is highly problematic und often requires a qualified histological/parasitological assessment. It is not possible to diagnose or exclude a cystic echinococcosis purely on the basis of a serological diagnosis. A multiple organ infection can be excluded using CT diagnostics as described in this case. The Robert Koch Institute has to be notified in the case of a positive result.
PMID: 22278168 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)
Source: Der Urologe. Ausg. A - January 27, 2012 Category: Urology & Nephrology Authors: Beckmann R, Homberg R, Niemann P, Reiter-Owona I Tags: Urologe A Source Type: research
The genome of a blood fluke associated with human cancerEmail this article to a colleague.
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The sequencing of the genome and transcriptome of Schistosoma haematobium, a highly prevalent blood fluke and human parasite with a proven link to malignant bladder cancer, marks the 160th anniversary of its discovery as the first schistosome known to infect humans. Comparative genomic analyses of S. haematobium and the more prevalent human-schistosomiasis pathogens (Schistosoma mansoni and Schistosoma japonicum) identified both shared and distinct genomic features. (Source: Nature Genetics)
Source: Nature Genetics - January 27, 2012 Category: Genetics & Stem Cells Authors: Makedonka Mitreva Tags: News and Views Source Type: research
