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This page shows you the most recent publications within this specialty of the MedWorm directory.

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From the Literature: Case ReportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Tags: News Source Type: journals

Genotyping of CYP21A2 for Congenital Adrenal Hyperplasia Screening using Allele-Specific Primer Extension followed by Bead Array HybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Oh, YongtaekSung Won Park,Chun, Sung-MinLim, NamkyooKi Sup Ahn,Ka, Jong-OkJin, Dong-KyuHan, Byoung-Don Tags: Short Communications Source Type: journals

Correlation Between Flagellin A (flaA) Genotypes and Antimicrobial Susceptibility Patterns of Campylobacter jejuni Strains Isolated from Children with Gastroenteritis in Athens, GreeceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Ioannidis, AnastassiosNicolaou, ChrysoulaChatzipanagiotou, Stylianos Tags: Short Communications Source Type: journals

Isothermal Single Nucleotide Polymorphism Genotyping and Direct PCR from Whole Blood Using a Novel Whole-Blood Lysis BufferEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Victor, Sylvia T.Lezhava, AlexanderIshidao, TakefumiEndo, RyutaMitani, YasumasaKawaoka, YoshihiroHayashizaki, Yoshihide Tags: Short Communications Source Type: journals

Influence of Some Cardiovascular Risk Factors on the Expression of Platelet Glycoprotein IIbIIIa Receptors in Patients with Myocardial Infarction Treated with Antiplatelet Drugs under Primary Percutaneous Coronary InterventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Konopka, AnnaSpychalska, JustynaPiotrowski, WalerianStepinska, Janina Tags: Original Research Article Source Type: journals

Molecular Classification of Cancers of Unknown Primary SiteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Greco, F. AnthonyErlander, Mark G. Tags: Review Articles Source Type: journals

Human Epidermal Growth Factor Receptor Dimerization Analysis in Breast Cancer Diagnosis: Potential for Improving Testing Accuracy and Treatment SelectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Spears, MelanieBartlett, John M.S. Tags: Review Articles Source Type: journals

Early Detection of Breast Cancer: New Biomarker Tests on the Horizon?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Jotwani, Aparna C.Gralow, Julie R. Tags: Review Articles Source Type: journals

AcknowledgmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Tags: Acknowledgment Source Type: journals

Single-molecule genomicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The term 'single-molecule genomics' (SMG) describes a group of molecular methods in which single molecules are detected or sequenced. The focus on the analysis of individual molecules distinguishes these techniques from more traditional methods, in which template DNA is cloned or PCR-amplified prior to analysis. Although technically challenging, the analysis of single molecules has the potential to play a major role in the delivery of truly personalized medicine. The two main subgroups of SMG methods are single-molecule digital PCR and single-molecule sequencing. Single-molecule PCR has a number of advantages over competin...
Source: The Journal of Pathology - November 20, 2009 Category: Pathology Authors: Frank McCaughan, Paul H Dear Source Type: journals

Clear cell sarcoma: Cytopathologic finding of a "tigroid" backgroundEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 20, 2009 Category: Pathology Authors: Swathi Eluri, Syed Z. Ali Source Type: journals

Topical tacrolimus and pimecrolimus in the treatment of oral lichen planus: an updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There is need for larger placebo-controlled, randomized studies with carefully selected and standardized outcome measures. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 20, 2009 Category: Pathology Authors: Pía López-Jornet, Fabio Camacho-Alonso, Noemi Salazar-Sanchez Source Type: journals

DNA ploidy in oral lichen planus, determined by image cytometryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The most common degree of DNA ploidy in OLP lesions was diploidy. Comparing the two groups (chi-square test of association P = 0.021) demonstrated that diploidy was associated with the reticular clinical form of OLP, while aneuploidy was associated with the atrophic-erosive clinical form of oral lichen planus. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 20, 2009 Category: Pathology Authors: Elaini Sickert Hosni, Liliane Soares Yurgel, Vinicius Duval da Silva Source Type: journals

Expression of tenascin and nucleolar organizer region in ameloblastoma and ameloblastic fibromaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Expression of tenascin in these neoplasms suggest that it could play a role in epithelial- mesenchymal interaction, while AgNORs reveal that ameloblastomas are more aggressive when compared with ameloblastic fibromas. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 20, 2009 Category: Pathology Authors: Sunitha Carnelio, Hitesh Vij Source Type: journals

Neuropathology of non-Alzheimer degenerative disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neurodegenerative diseases are characterized by selective and progressive loss of specific populations of neurons, which determines the clinical presentation. The same neuronal populations can be affected in a number of different disorders. Given that the clinical presentation reflects the particular population of neurons that are targets of the disease process, it is clear that for any given clinical syndrome, more than one neurodegenerative disease can account for the clinical syndrome. Because of this clinical ambiguity, for the purpose of this brief review neurodegenerative disorders are classified according to the...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Dickson DW Tags: Int J Clin Exp Pathol Source Type: journals

HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HMGB1, an evolutionarily conserved chromosomal protein, was recently re-discovered to act as a "danger signal" (alarmin) to alert the innate immune system for the initiation of host defense or tissue repair. Extracellular HMGB1 can be either passively released from damaged/necrotic cells or secreted by activated immune cells. Upon stimulation, dendritic cells (DCs), macrophages and natural killer (NK) cells secrete high levels of HMGB1 into the intercellular milieu. HMGB1 is potent to target DCs, macrophages, neutrophils and CD4(+) T cells. It also upregulates the expression of BCL-XL by which it may prevent the elimin...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Zhang S, Zhong J, Yang P, Gong F, Wang CY Tags: Int J Clin Exp Pathol Source Type: journals

Pitfalls in diagnostic hematopathology - Part II.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The overlapping features of malignant lymphomas create a diagnostic "grey zone" , and lead to the invention of "grey zone lymphomas". There are several major grey zone lymphomas: 1) Lymphomas with overlapping features of Hodgkin lymphoma and large B-cell lymphoma; 2) Lymphomas with overlapping features of Burkitt lymphoma and diffuse large B-cell lymphoma; 3) Lymphomas with overlapping features of nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte rich large B-cell lymphoma; 4) Lymphomas with overlapping features of Hodgkin lymphoma, anaplastic large cell lymphoma (ALCL) and peripheral T-cell lymphom...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Zhao XF Tags: Int J Clin Exp Pathol Source Type: journals

The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
GATA4 is a transcription factor that plays a role in regulating the normal development of many mesoderm and endoderm derived tissues, including the pancreas. Silencing of GATA4 mRNA expression by promoter methylation has been implicated in carcinogenesis of the ovary, lung and colorectum. By contrast, GATA4 mRNA expression is upregulated in pancreatic cancer cell lines and tissues. To further clarify the relationship of GATA4 to pancreatic cancer, we immunolabeled 90 samples of pancreatic ductal adenocarcinoma using a GATA4 specific monoclonal antibody. Both the intensity and percent of labeling was recorded for each c...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Karafin MS, Cummings CT, Fu B, Iacobuzio-Donahue CA Tags: Int J Clin Exp Pathol Source Type: journals

MPEP Reduces Seizure Severity in Fmr-1 KO mice over Expressing Human Abeta.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metabotropic glutamate receptor 5 (mGluR(5)) regulates the translation of amyloid precursor protein (APP) mRNA. Under resting conditions, mRNA is bound to and translationally repressed by the fragile X mental retardation protein (FMRP). Upon group 1 mGluR activation, FMRP dissociates from the mRNA and translation ensues. APP levels are elevated in the dendrites of primary neuronal cultures as well as in synaptoneurosomes (SN) prepared from embryonic and juvenile fmr-1 knockout (KO) mice, respectively. In order to study the effects of APP and its proteolytic product Abeta on Fragile X syndrome (FXS) phenotypes, we creat...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Westmark CJ, Westmark PR, Malter JS Tags: Int J Clin Exp Pathol Source Type: journals

Plugs clog the glandular outlets in fundic gland polyps.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A systematic histologic analysis of 62 gastric fundic gland polyps (FGP) was carried out. All FGP (100%) showed foveolar cells with hypertrophic cytoplasm. In 95% of the FGP, parietal cells ballooned into the lumen and in 93%, exfoliated anucleated structures with eosinophilic granules were found. Plugs of anucleated structures with eosinophilic granules, most likely derived from exfoliated parietal cells, were found to clog the outlets of the glands in 86% of the FGP. None of the 30 control gastric biopsies without FGP had similar cellular aberrations. FGP seems to evolve by cellular aberrations affecting parietal cel...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Rubio CA Tags: Int J Clin Exp Pathol Source Type: journals

Diagnosis of biphenotypic acute leukemia: a paradigmatic approach.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biphenotypic acute leukemia (BAL), or acute leukemia with a single population of blasts coexpressing markers of two different lineages, is a rare clinical entity. To define BAL, a scoring system was proposed by the European Group of Immunological Markers for Leukemias (EGIL) in 1995. However, increasing evidence suggests that this system has limitations, as acknowledged by the 2008 World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissues. Although substantially improved in relation to the EGIL, the new WHO Classification is still not optimal for guiding the clinical management of p...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Zhao XF, Gojo I, York T, Ning Y, Baer MR Tags: Int J Clin Exp Pathol Source Type: journals

Columnar cell lesions and pseudoangiomatous hyperplasia like stroma: is there an epithelial-stromal interaction?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The significance of association between cancer and its microenvironment has been increasingly recognized. It has been shown in animal models that interaction between neoplastic epithelial cells and adjacent stroma can modulate tumor behavior. Carcinoma associated stromal cells can transform normal epithelial cells into neoplastic cells. In breast, columnar cell lesions are non-obligate precursors of low grade ductal carcinoma in situ. Columnar cell lesions can be seen intimately associated with PASH-like-stroma, a lesion we termed as CCPLS. Our aim is to investigate epithelial-stromal interactions in CCPLS and compare ...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Recavarren RA, Chivukula M, Carter G, Dabbs DJ Tags: Int J Clin Exp Pathol Source Type: journals

Utility of desmin and a Masson's trichrome method to detect early acute myocardial infarction in autopsy tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Detection of early acute myocardial ischemia/infarction prior to neutrophilic infiltration in autopsy myocardium poses a diagnostic dilemma to the surgical pathologist. Morphological changes can be subtle or not identified at all on the hematoxylin and eosin stain. To evaluate the Masson's trichrome stain and immunohistochemical stains, desmin and myoglobin, in detecting acute myocardial ischemia/infarction in autopsy myocardium. We reviewed the autopsy files of the New York Harbor Healthcare System and retrieved 25 cases of early acute myocardial infarction. Three autopsy hearts of non-cardiac related deaths were used...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Ouyang J, Guzman M, Desoto-Lapaix F, Pincus MR, Wieczorek R Tags: Int J Clin Exp Pathol Source Type: journals

Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 70 year old male with stage IV chronic lymphocytic leukemia complicated by aplastic anemia. Neurological examination and imaging revealed no significant abnormalities. At autopsy, the brain revealed multifocal cysts and free tachyzoites of Toxoplasma gondii with diffuse microglial nodules and no necrosis. To the best of our knowledge, this case represents the first report of the "encephalitic" form of toxoplasmosis in a non-AIDS patient. PMID: 19918334 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Abedalthagafi M, Rushing EJ, Garvin D, Cheson B, Ozdemirli M Tags: Int J Clin Exp Pathol Source Type: journals

Persistent non-neoplastic gammadelta-T cells in cerebrospinal fluid of a patient with hepatosplenic (gammadelta) T cell lymphoma: a case report with 6 years of flow cytometry follow-up.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of a 31-year old man diagnosed with a gammadelta HSTCL in 2003, successfully treated with chemotherapy and allogeneic stem cell transplantation, and followed from 2003 to present. Four-color flow cytometry (FC) was performed on a BD FACSCalibur and data analyzed with CellQuest Pro and FCS Express software. For cerebrospinal fluid (CSF), all cells were acquired due to limited material. Cytological correlation was available on all specimens. Molecular studies for T-cell gene rearrangement were non-contributory. By FC, the diagnostic HSTCL immunophenotype was CD3 (+), CD7 (+), CD2 (+), CD5 (-), CD4 (-), CD8...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Jiang L, Abati AD, Wilson W, Stetler-Stevenson M, Yuan C Tags: Int J Clin Exp Pathol Source Type: journals

Silicone implant and primary breast ALK1-negative anaplastic large cell lymphoma, fact or fiction?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe an additional case of primary breast ALK1-negative ALCL in the fibrous capsule and cystic fluid of silicone breast implant in a 58 year old woman who underwent breast reconstructive surgery after lumpectomy for her infiltrating breast adenocarcinoma. Morphologically and immunohistochemically, the lymphoma cells may be confused with recurrent infiltrating breast adenocarcinoma or other non-hematolymphoid malignancies. Molecular studies were needed to determine T-lineage differentiation of the malignant lymphoma cells. We will also review the case reports and case series published in the English l...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Li S, Lee AK Tags: Int J Clin Exp Pathol Source Type: journals

The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decadeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the last decade, the development of microarrays and the ability to perform massively parallel gene expression analysis of human tumours were received with great excitement by the scientific community. The promise of microarrays was of apocalyptic dimensions, with some experts envisaging that it would be a matter of a few years for this technology to replace traditional clinicopathological markers in clinical practice and treatment decision-making. The replacement of histopathology by high-tech and more objective approaches to cancer diagnosis, prognostication and prediction was, at that time, a foregone conclusion. Ten ...
Source: The Journal of Pathology - November 19, 2009 Category: Pathology Authors: Britta Weigelt, Frederick L Baehner, Jorge S Reis-Filho Source Type: journals

The role of nuclear organization in cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The functional significance of changes in nuclear structure and organization in transformed cells remains one of the most enigmatic questions in cancer biology. In this review, we discuss relationships between nuclear organization and transcription in terms of the three-dimensional arrangement of genes in the interphase cancer nucleus and the regulatory functions of nuclear matrix proteins. We also analyse the role of nuclear topology in the generation of gene fusions. We speculate that this type of multi-layered analysis will one day provide a framework for a more comprehensive understanding of the genetic origins of canc...
Source: The Journal of Pathology - November 19, 2009 Category: Pathology Authors: Elliott Lever, Denise Sheer Source Type: journals

General lessons from large-scale studies to identify human cancer predisposition genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are now about 100 genes known to cause Mendelian inherited cancer syndromes, but these only explain a minor part of the familial clustering of the common cancers. The increased familial relative risk of cancer in the general population must largely involve genes of low- or moderate-penetrance. Until recently, attempts to identify cancer predisposition genes with low penetrance had proved similarly unrewarding. However, in the past 2 years, developments in this area have been rapid. In particular, the 'common disease-common variant' model of predisposition has come to the fore. In this model, alleles of high frequency...
Source: The Journal of Pathology - November 19, 2009 Category: Pathology Authors: Jean-Baptiste Cazier, Ian Tomlinson Source Type: journals

Polymicrobial lung infection in postrenal transplant recipient diagnosed by fine-needle aspiration cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of concomitant pulmonary cryptococcosis, aspergillosis, and tuberculosis in a renal transplant recipient diagnosed on FNAC.A 50-year-old renal transplant recipient, asymptomatic for 3 year, presented with intermittent low-grade fever associated with cough, expectoration, and a newly developed cavitatory lesion in the left lung on chest X-ray. Computed tomography-guided FNAC performed on the lung lesion showed fungal profiles with septate hyphae and acute-angled branching consistent with morphology of Aspergillus. In addition, numerous yeast forms of cryptococcus and a few acid-fast mycobacterial tubercle b...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Rajan Duggal, Arvind Rajwanshi, Nalini Gupta, Anupam Lal, Manphool Singhal Source Type: journals

Bursal gouty tophus: Fine-needle aspiration cytology intrabursal tophus on FNACEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Akansha Gandhi, Seema Aggarwal, Apurba Rajbongshi, Vinod Kumar Arora Source Type: journals

Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of cystadenocarcinoma causing difficulty in cytological diagnosis. A 23-year-old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years. The mass was elastic hard, measuring 30 × 35 mm in diameter. Preoperative fine-needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid. The cluster was arranged in a ball-like structure and was cohesive with overlapping. Tumor cells had a small vacuolated, soap-bubble appearance in the cytoplasm. The papillary-cystic variant of acinic cell carcinoma (ACC-PCV) was suggested from these ...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Akihiko Kawahara, Hiroshi Harada, Hiroyuki Mihashi, Jun Akiba, Masayoshi Kage Source Type: journals

Cervical cytology in patients with postmenopausal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the role of cervical cytology in the diagnosis of post or perimenopausal (PM) bleeding was explored. A total of 135 patients with PM bleeding were selected. In all these cases both conventional cervical cytology and histopathology follow up were available. The commonest causes of postmenopausal (PM) bleeding with abnormal histopathology were squamous cell carcinoma of cervix (14), endocervical polyp (13), endometrial adenocarcinomas (13) and simple hyperplasia without atypia (13). There were a total 13 cases of endometrial adenocarcinoma and cervical smears of these cases were reported as high grade squamous...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Jasleen Kaur, Pranab Dey, Subhash Chandra Saha, Arvind Rajwanshi, Raje Nijhawan, Srinivasan Radhika, Nalini Gupta Source Type: journals

2+ HER-2/neu IHC results: positively equivocalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 19, 2009 Category: Pathology Authors: Jean D. Kemp, Michael C. Royer Source Type: journals

Significance of podoplanin expression in keratocystic odontogenic tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Podoplanin is strongly expressed in KCOTs in comparison with OOCs. The pattern of staining for podoplanin in KCOT could be related to its neoplastic nature, and suggests a role of the protein in tumor invasiveness. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 19, 2009 Category: Pathology Authors: Eri Okamoto, Kentaro Kikuchi, Yuji Miyazaki, Patricia González-Alva, Yuka Oku, Akio Tanaka, Noriaki Yoshida, Masahiro Fujinami, Fumio Ide, Hideaki Sakashita, Kaoru Kusama Source Type: journals

Aperio Awarded Patent for Client/Server Image AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Aperio Technologies | Press Releases)
Source: Aperio Technologies | Press Releases - November 18, 2009 Category: Pathology Source Type: organizations

Adverse effect of heroin hydrochloride on selected male reproductive parameters in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the effects of heroin on selected male reproductive parameters in mice (Balb/C), e.g. body weight, testis weight, gonado-somatic index, sperm viability, concentration of serum testosterone and fertility rate. Seventy-two mice (36 male and 36 female) were used. The male mice were divided into two control and two experimental groups. For evaluation of fertility rate, three mice were chosen from each group. Experimental groups of heroin-dependant mice were divided into two groups: Experimental group I were given heroin at a dose of 5 mg/kg and experimental group II 5 mg/ml, intra-peritone...
Source: Comparative Clinical Pathology - November 18, 2009 Category: Pathology Tags: Comparative Clinical Pathology Source Type: journals

CD 9 and vimentin distinguish clear cell from chromophobe renal cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Based on gene expression analysis, we identify CD9 and vimentin as candidate markers for distinguishing between ccRCC and chRCC. In difficult cases and particularly when the amount of diagnostic tissue is limited, vimentin and CD9 staining could serve as a useful adjunct in the differential diagnosis of ccRCC and chRCC. (Source: BMC Clinical Pathology - Latest articles)
Source: BMC Clinical Pathology - Latest articles - November 18, 2009 Category: Pathology Authors: Ariel WilliamsJohn HigginsHongjuan ZhaoBorje LjunbergJames Brooks Source Type: journals

Lymphoepitelioma-like carcinoma of the skin: report of three casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe three new cases of this entity that support an epidermic origin. López V, Martín JM, Santonja N, Molina I, Ramón D, Monteagudo C, Jordá E. Lymphoepitelioma-like carcinoma of the skin: report of three cases (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: Verónica López, José M. Martín, Nuria Santonja, Inmaculada Molina, Dolores Ramón, Carlos Monteagudo, Esperanza Jordá Source Type: journals

Borderline CD30+ cutaneous lymphoproliferative disorder: report of a case with expression of cytotoxic markers and response to clarithromycinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of borderline CD30+ CLPD with cytotoxic phenotype, presenting in a 22-year-old male patient as an ulcer on the forearm. He reported having had similar ulcers on the buttock and thigh that spontaneously regressed over the course of 1 year. The lesion resolved with a single course of clarithromycin; a subsequent lesion, too, responded to clarithromycin, and no recurrences or systemic involvement have been documented in the 9-month follow-up. A conservative approach in the management of CD30+ CLPD is recommended. We believe that the anti-inflammatory and apoptotic effects of clarithromycin on T cells may ha...
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: Pedro Ponte, Vasco Serrão, Isabel Viana, Esmeralda Vale, Alexandre João, Lorenzo Cerroni Source Type: journals

De novo intraepidermal epithelioid melanocytic dysplasia: an emerging entityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
De novo intraepidermal epithelioid melanocytic dysplasia represents a distinctive form of intraepidermal melanocytic dysplasia. Although these lesions are atypical, they are not diagnostic of melanoma. They are considered a part of the atypical mole phenotype and may define a point in the natural course of melanomagenesis. Magro CM, Crowson AN, Mihm MC, Kline M. De novo intraepidermal epithelioid melanocytic dysplasia: an emerging entity of diagnostic and clinical importance. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: Cynthia M. Magro, A. Neil Crowson, Martin C. Mihm, Mitchell Kline Source Type: journals

Comparison between PAS and GMS stains for the diagnosis of onychomycosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PAS and GMS stains are quantitatively similar. Sensitivity of both methods can be increased by preparing two slides from different levels in the paraffin block. Reza Kermanshahi T, Rhatigan R. Comparison between PAS and GMS stains for the diagnosis of onychomycosis. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: Taher Reza Kermanshahi, Ronald Rhatigan Source Type: journals

Human neuroblastoma cell line SNU-NB1 loses sensitivity to brain-derived neurotrophic factor during establishmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The patterns of trkA and trkB mRNA expression were markers for different lineages of transformed cells but were inconsistent with the clinical behavior. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - November 18, 2009 Category: Pathology Authors: Woong Jae Yun, Soo Hee Kim, Eun Shin, Ja June Jang, Kyoungbun Lee Source Type: journals

Peripancreatic lymph node gastrinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastrinoma is one of the most symptomatic pancreatic endocrine tumors and is associated with recurrent gastric or duodenal ulcer and an induction of chronic gastric acid hypersecretion. This tumor is commonly involved within the gastrinoma triangle. Herein we report a peripancreatic lymph node gastrinoma in a 56-year-old man who was suffered from a recurrent duodenal or jejunal ulcer perforation. Octreotide scan detected a peripancreatic or periduodenal mass and the serum gastrin level was set in upper normal range (107.73 pg/mL). Whipple's procedure was performed. The resected specimen showed multiple duodenal ulcers, hyp...
Source: Basic and Applied Pathology - November 18, 2009 Category: Pathology Authors: Si-Hyong Jang, Se Min Jang, Young Jin Jun, Woong Na, Kyueng Whan Min, Ki-Seok Jang, Seung Sam Paik Source Type: journals

How overworked are pathologists? An assessment of cases for histopathology and cytopathology servicesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We propose a mean plus a standard deviation as a recommended guideline for staff workload at each laboratory setting to be used for a quality assurance program. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - November 18, 2009 Category: Pathology Authors: Hye Kyoung Yoon, Michele H Diwa, Youn Soo Lee, Gwangil Kim, Sang Yong Song, Kyoung Bun Lee, Han Kyeom Kim, Woon Sup Han, Jeong-Wook Seo Source Type: journals

Network-based drugs and biomarkersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The structure and dynamics of protein signalling networks governs cell decision processes and the formation of tissue boundaries. Complex diseases such as cancer and diabetes are diseases of such networks. Therefore approaches that can give insight into how these networks change during disease progression are crucial for better understanding, detection and intervention. The era of network medicine has begun; however, there are fundamental principles associated with molecular networks that are essential to consider for this field to succeed. Here, we introduce network biology and some of its associated technologies. We then...
Source: The Journal of Pathology - November 18, 2009 Category: Pathology Authors: Janine T Erler, Rune Linding Source Type: journals

DNIEMD and other acronymsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: François Milette Source Type: journals

CD98 expression is decreased in papillary carcinoma of the thyroid and Hashimoto's thyroiditisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CD98 expression is down-regulated in thyroid papillary carcinoma; this may relate to the better prognosis associated with many of these tumours. (Source: Histopathology)
Source: Histopathology - November 18, 2009 Category: Pathology Authors: Catriona E Anderson, Catriona Graham, Michael M Herriot, Hassan M Kamel, Donald M Salter Source Type: journals

Establishment and characterization of a novel human malignant peripheral nerve sheath tumor cell line, FMS-1, that overexpresses epidermal growth factor receptor and cyclooxygenase-2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma. We established a new human MPNST cell line (designated FMS-1) from MPNST of the right brachial plexus of a 69-year-old woman with NF1. The cell line has been maintained for >24 months with >100 passages. FMS-1 cells showed a fibrosarcoma-like or epithelioid pattern in the heterotransplanted tumor, compared with a fascicular growth pattern of short-spindle tumor cells in the primary tumor. Immunophenotypically, FMS-1 cells showed almost the same characteristics as the primary tumor. Cytogenetic and molecular ana...
Source: Virchows Archiv - November 17, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined by immunohistochemistry the expression of three novel matrix metalloproteinases (MMPs)—MMP-21, MMP-26, and MMP-28—in 44 primary MCC tumors and six lymph node metastases while MMP-10 served as a positive control. Their mRNA expression was also studied in the UISO MCC cell line basally and after various stimulations using quantitative real-time PCR. MMP-28 was observed in tumor cells of 15/44 samples especially in tumors <2 cm in diameter (p = 0.015) while 21/44 specimens showed MMP-28 in the tumor stroma. Expression of MMP-21 was demonstrated in tumor cells of 13/43 samples. MMP-26, instead,...
Source: Virchows Archiv - November 17, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals