PathologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory.

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30

Elevated expression of SOX9 is related with the progression of gastric carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To investigate the SOX9 expression and its effects on promoting invasion and metastasis in the primary gastric adenocarcinomas. One hundred and eighty six patients with primary gastric adenocarcinomas who underwent surgery between 2002 and 2006 were classified as low, intermediate, and high SOX9 expression groups by immunohistochemistry (IHC). Our IHC performance showed that SOX9 was lowly expressed in lower crypt of the normal epithelium adjacent to the tumor, and SOX9 expression was also observed in the intestinal metaplastic epithelium, but no SOX9 expression was detected in the surface epithelium. The stronger SOX9 exp...
Source: Diagnostic Cytopathology - March 19, 2010 Category: Pathology Authors: Cheng-Jun Zhou, Jian-Qiang Guo, Kong-Xi Zhu, Qing-Hui Zhang, Cheng-Ran Pan, Wei-Hua Xu, Hong-Juan Wang, Bin Liu Source Type: journals

Alternate mucoid and hyalinized stroma in clear cell carcinoma of the ovary: manifestation of serial stromal remodelingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
mp; Teiichi Motoyama (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - March 19, 2010 Category: Pathology Authors: Noriko KatoJunko TakedaMasayuki FukaseTeiichi Motoyama Tags: clear cell carcinoma hyalinized stroma ovary spherule-like mucoid stroma Source Type: journals

Hydrophilic polymer emboli: an under-recognized iatrogenic cause of ischemia and infarctEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Michael C Fishbein (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - March 19, 2010 Category: Pathology Authors: Rupal I MehtaRashi I MehtaOrestes E SolisReza JahanNoriko SalamonJonathan M TobisWilliam H YongHarry V VintersMichael C Fishbein Tags: hydrophilic polymer interventional procedure catheter guidewire pulmonary infarct cerebral infarct Source Type: journals

Reduced expression of SMARCB1/INI1 protein in synovial sarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reduced expression of SMARCB1/INI1 protein in synovial sarcoma Modern Pathology advance online publication, March 19, 2010. doi:10.1038/modpathol.2010.71 Authors: Kenichi Kohashi, Yoshinao Oda, Hidetaka Yamamoto, Sadafumi Tamiya, Hiroshi Matono, Yukihide Iwamoto, Tomoaki Taguchi & Masazumi Tsuneyoshi (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - March 19, 2010 Category: Pathology Authors: Kenichi KohashiYoshinao OdaHidetaka YamamotoSadafumi TamiyaHiroshi MatonoYukihide IwamotoTomoaki TaguchiMasazumi Tsuneyoshi Tags: SMARCB1/INI1 synovial sarcoma malignant rhabdoid tumor SS18-SSX chromatin remodeling Source Type: journals

Warty–basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Warty–basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases Modern Pathology advance online publication, March 19, 2010. doi:10.1038/modpathol.2010.69 Authors: Alcides Chaux, Pheroze Tamboli, Alberto Ayala, Fernando Soares, Ingrid Rodríguez, José Barreto & Antonio L Cubilla (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - March 19, 2010 Category: Pathology Authors: Alcides ChauxPheroze TamboliAlberto AyalaFernando SoaresIngrid RodríguezJosé BarretoAntonio L Cubilla Tags: penile squamous cell carcinoma warty carcinoma basaloid carcinoma human papillomavirus penile intraepithelial neoplasia prognosis Source Type: journals

Progenitor stem cell marker expression by pulmonary carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
amp; Robert J Downey (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - March 19, 2010 Category: Pathology Authors: Andre L MoreiraMithat GonenNatasha RekhtmanRobert J Downey Tags: lung cancer cell surface marker differentiation Source Type: journals

Marginal zone lymphomas in children and the young adult population; characterization of genetic aberrations by FISH and RT-PCREmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Elaine S Jaffe (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - March 19, 2010 Category: Pathology Authors: Kathryn A RizzoBerthold StreubelStefania PittalugaAndreas ChottLiqiang XiMark RaffeldElaine S Jaffe Tags: marginal zone lymphoma pediatric genetic aberrations Source Type: journals

New pattern of EGFR amplification in glioblastoma and the relationship of gene copy number with gene expression profileEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Miguel Cerdá-Nicolas (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - March 19, 2010 Category: Pathology Authors: Concha Lopez-GinesRosario Gil-BensoRuben Ferrer-LunaRafael BenitoEva SernaJose Gonzalez-DarderVicente QuilisDaniel MonleonBernardo CeldaMiguel Cerdá-Nicolas Tags: glioblastoma EGFR amplification insertion microarrays SNPs Source Type: journals

Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Massimo Falconi (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - March 19, 2010 Category: Pathology Authors: Aldo ScarpaWilliam MantovaniPaola CapelliStefania BeghelliLetizia BoninsegnaRossella BettiniFrancesco PanzutoPaolo PederzoliGianfranco delle FaveMassimo Falconi Tags: pancreas tumors endocrine staging TNM grading prognosis Source Type: journals

Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Robert A Soslow (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - March 19, 2010 Category: Pathology Authors: Laura J TafeKaruna GargIvy ChewCarmen TornosRobert A Soslow Tags: endometrium ovary undifferentiated carcinoma endometrioid carcinoma DNA mismatch repair malignant mixed Mullerian tumor Source Type: journals

Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hybrid oncocytic/chromophobe tumors (HOCT) of the kidney have been described in patients with Birt–Hogg–Dubé syndrome (BHD) and in association with renal oncocytosis without BHD. HOCT in patients without evidence of BHD or renal oncocytosis is exceedingly rare, and these cases have been poorly characterized. We have identified and studied 14 cases of HOCT from previously diagnosed renal oncocytomas (398 cases) and chromophobe renal cell carcinomas (351 cases) without evidence of BHD or renal oncocytosis. Immunohistochemical, ultrastructural, and molecular genetic studies analyzing numerical chr...
Source: Virchows Archiv - March 18, 2010 Category: Pathology Tags: Virchows Archiv Source Type: journals

Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Histo-blood group antigens CD173 (H2) and CD174 (Lewis Y) are known to be developmentally regulated carbohydrate antigens which are expressed to a varying degree on many human carcinomas. We hypothesized that they might represent markers of cancer-initiating cells (or cancer stem cells, CSC). In order to test this hypothesis, we examined the co-expression of CD173 and CD174 with stem cell markers CD44 and CD133 by flow cytometry analysis, immunocytochemistry, and immunohistochemistry on cell lines and tissue sections from breast cancer. In three breast cancer cell lines, the percentage of CD173+/CD4...
Source: Virchows Archiv - March 18, 2010 Category: Pathology Tags: Virchows Archiv Source Type: journals

Am J Pathol; +105 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
105 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These pubmed results were generated on 2010/03/18PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Pathol)
Source: Am J Pathol - March 18, 2010 Category: Pathology Tags: Report Source Type: journals

Induction and progression of cholangiofibrosis in rat liver injured by oral administration of furan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cholangiofibrosis is a structural anomaly that precedes the development of cholangiocarcinoma in some rodent models. In this article, the authors examine the contribution of the epithelial and mesenchymal cells in the pathogenesis of this complex lesion. Furan was administered to rats by gavage in corn oil at 30 mg/kg b.w. (five daily doses per week) and livers were sampled between eight hr to three months. Characteristically the administration of furan caused centrilobular injury, and restoration was accomplished by proliferation of hepatocytes. Some areas of the liver were, however, more severely affected, and here, ...
Source: Toxicologic Pathology - March 18, 2010 Category: Pathology Authors: Hickling KC, Hitchcock JM, Chipman JK, Hammond TG, Evans JG Tags: Toxicol Pathol Source Type: journals

Instructions for figures.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 20231549 [PubMed - in process] (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - March 18, 2010 Category: Pathology Tags: Toxicol Pathol Source Type: journals

STATLINE Issue March 18, 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In This Issue: Congressional Lab Tour: Dr. Maury Fremont-Smith Hosts Senate Candidate, Kelly Ayotte - Healthcare Reform Comes Down to the Wire - Senate Approves 7-Month Extension of SGR; House Vote Next - Physicians Urge Extension of Medicare Selection Period - NIH Announces Genetic Testing Registry - CAP to CMS: Laboratory Must Have Full Access to Electronic Health Records - PECOS Registration Requirement Delayed Until 2011 (Source: STATLINE Federal and State News Briefs)
Source: STATLINE Federal and State News Briefs - March 18, 2010 Category: Pathology Source Type: organizations

Educating medical students in laboratory medicine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 20231603 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Wilson ML Tags: Am J Clin Pathol Source Type: journals

Looking through a keyhole: serrated neoplasia in the vermiform appendix.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 20231604 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Upton MP Tags: Am J Clin Pathol Source Type: journals

Educating Medical Students in Laboratory Medicine: A Proposed Curriculum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
y CA, Wolf P, Wu YY, As the 100th anniversary of the Flexner report nears, medical student education is being reviewed at many levels. One area of concern, expressed in recent reports from some national health care organizations, is the adequacy of training in the discipline of laboratory medicine (also termed clinical pathology). The Academy of Clinical Laboratory Physicians and Scientists appointed an ad hoc committee to review this topic and to develop a suggested curriculum, which was subsequently forwarded to the entire membership for review. The proposed medical student laboratory medicine curriculum defines goa...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, Rinder HM, Roberts W, Schreiber WE, Spitalnik SL, Torm Tags: Am J Clin Pathol Source Type: journals

Occupational hazard for pathologists: microscope use and musculoskeletal disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The association of prolonged microscope use with the development of chronic pain syndromes has been recognized for nearly 3 decades; yet most pathologists are not well-informed about this hazard until after they develop a problem. The purpose of this article is to make pathologists aware of this risk, discuss current pathogenetic models, and encourage them to proactively integrate prevention strategies into their daily lives. PMID: 20231606 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: George E Tags: Am J Clin Pathol Source Type: journals

Comparison of plasma with whole blood prothrombin time and fibrinogen on the same instrument.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We compared plasma with whole blood (WB) international normalized ratio (INR) and fibrinogen using the same instrument and reagents. WBINRs were 50% higher than plasma INRs. After increasing the WB sample volume 40% and adjusting the International Sensitivity Index, WBINRs were similar to plasma INRs [adjusted WBINR = 0.99(plasma INR) - 0.02; r(2) = 0.98; n = 155], but the average difference in WB vs plasma INR was 4-fold higher than duplicate plasma INRs. Variation in hematocrit was a major determinant of the accuracy of the WBINR, with increased error at high INRs. The WB fibrinogen assay was highly dependent on the ...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Amukele TK, Ferrell C, Chandler WL Tags: Am J Clin Pathol Source Type: journals

Comparison of QIAGEN Automated Nucleic Acid Extraction Methods for CMV Quantitative PCR Testing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates the feasibility of using 2 different extraction techniques to yield results within 0.5 log(10) copies/mL of the mean value, a level that would allow for clinical comparison between different laboratory assays. PMID: 20231608 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Miller S, Seet H, Khan Y, Wright C, Nadarajah R Tags: Am J Clin Pathol Source Type: journals

Use of the RQI Test for Bacterial Screening of Whole Blood Platelets.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We compare our experience using a new rapid qualitative immunoassay (RQI) test (platelet Pan Genera Detection, Verax, Worcester, MA) for bacterial screening of whole blood platelet (WBP) pools with our previous WBP bacterial screen, pH testing. All WBP pools were RQI tested at the time of issue. All RQI+ pools were cultured in an automated culture system, with subsequent bacterial identification if the culture was positive. During approximately 5.5 months, 7,733 WBP pools were RQI tested. There were 14 positive RQI tests; 12 WBP pools were sterile when cultured and considered false-positive RQI tests. One pool was posi...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Yazer MH, Stapor D, Triulzi DJ Tags: Am J Clin Pathol Source Type: journals

Increased Sensitivity and Specificity of Borrelia burgdorferi 16S Ribosomal DNA Detection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The DNA of Borrelia burgdorferi spirochetes extracted by ammonium hydroxide was used as the template for nested polymerase chain reaction (PCR) amplification of the species-specific 16S ribosomal DNA (rDNA). The primers were those well known to be specific for signature sequence amplification of the B burgdorferi sensu lato 16S ribosomal RNA gene. The positive 293-base-pair nested PCR amplicon was subjected to routine direct automated Sanger sequencing. A 50-base sequence excised randomly from the sequencing electrophoretogram between the 2 nested PCR primer binding sites was sufficient for the Basic Local Alignment Se...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Lee SH, Vigliotti VS, Vigliotti JS, Jones W, Pappu S Tags: Am J Clin Pathol Source Type: journals

Evaluation of the Sysmex UF-1000i for the Diagnosis of Urinary Tract Infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diagnosis of urinary tract infection (UTI) is primarily done by microbiologic culture, which is time-consuming and can produce false-positives and false-negatives. Flow cytometry allows for rapid screening of many samples and eliminates culturing. We analyzed the Sysmex UF-1000i (TOA Medical Electronics, Kobe, Japan) for accuracy in identifying RBCs and WBCs, casts, bacteria, and epithelia. We also evaluated its precision, linear estimation of results, carryover contamination rate, and anti-interference. UF-1000i agreement with manual counting was approximately 95% for RBCs and WBCs, epithelia, and casts. Its coefficie...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Wang J, Zhang Y, Xu D, Shao W, Lu Y Tags: Am J Clin Pathol Source Type: journals

Coexisting follicular and mantle cell lymphoma with each having an in situ component: a novel, curious, and complex consultation case of coincidental, composite, colonizing lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a spleen revealing histologic features of follicular lymphoma, without any indication of a second lymphoma. Immunohistochemical stains supported this diagnosis and showed the follicular lymphoma to be BCL2-. However, these studies revealed 2 additional unexpected findings: cyclin D1+ mantle zone cells surrounding neoplastic and reactive follicles (indicative of in situ mantle cell lymphoma) and BCL2-bright, histologically nonneoplastic follicles (indicative of in situ follicular lymphoma). ImmunoFISH and microdissection and polymerase chain reaction analysis documented the clonal nature of the cyclin D...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Roullet MR, Martinez D, Ma L, Fowler MH, McPhail ED, Judkins A, Arber DA, Bagg A Tags: Am J Clin Pathol Source Type: journals

Minimal residual disease detection by flow cytometry in adult T-cell leukemia/lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Little information exists regarding the detection of minimal residual disease (MRD) in adult T-cell leukemia/lymphoma (ATLL). We evaluated 75 peripheral blood samples from 17 ATLL cases using flow cytometry (FC); 50 of the samples were concurrently evaluated by polymerase chain reaction (PCR) for clonal T-cell receptor gamma chain (TRG) gene rearrangement and the presence of human T-cell lymphotropic virus-1 proviral sequences. Residual ATLL cells were identified using a multiparametric approach to identify aberrant T-cell immunophenotypes. Malignant T cells were CD4+, CD3 dim+, CD26-, CD25 bright, CD7+, and CD27+, wit...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Shao H, Yuan CM, Xi L, Raffeld M, Morris JC, Janik JE, Stetler-Stevenson M Tags: Am J Clin Pathol Source Type: journals

Molecular pathology of myeloproliferative neoplasms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Myeloproliferative neoplasms (MPNs; formerly chronic myeloproliferative disorders) are a class of myeloid hematologic malignancies that represent a stem cell-derived expansion of 1 or more hematopoietic cell lineages. The current 2008 World Health Organization system recognizes 8 types of MPN: chronic myelogenous leukemia, chronic neutrophilic leukemia, polycythemia vera, primary myelofibrosis, essential thrombocythemia, chronic eosinophilic leukemia, mastocytosis, and myeloproliferative neoplasm, unclassifiable. This review summarizes the salient characteristics of the MPNs, with emphasis on recent developments in the...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Klco JM, Vij R, Kreisel FH, Hassan A, Frater JL Tags: Am J Clin Pathol Source Type: journals

Primary sclerosing neuroendocrine carcinomas of the lung: a clinicopathologic and immunohistochemical study of 10 cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe 10 cases of primary well-differentiated neuroendocrine carcinomas (carcinoid tumor) of the lung with extensive sclerotic changes. The patients were 6 women and 4 men from 20 to 69 years of age. Clinically, patients had symptoms of bronchial obstruction such as cough, dyspnea, and chest pain. Surgical resection of the tumors was accomplished in all the cases. Histologically, all tumors corresponded to the well-differentiated type; however, in 4 cases, lymph node metastases were present. Immunohistochemically, all tumors showed positive staining for neuroendocrine markers, including chromogranin, synaptophysin, C...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Kalhor N, Suster S, Moran CA Tags: Am J Clin Pathol Source Type: journals

Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We performed a histologic and immunohistochemical assessment of 53 noninvasive appendiceal epithelial proliferations, appropriating terminology and using markers shown useful in differentiating serrated colorectal polyps. These were classified as hyperplastic polyp (HP), sessile serrated adenoma (SSA), mixed serrated and adenomatous lesion (MSAL), mucinous cystadenoma (MCA), or conventional adenoma (CAD). Immunohistochemical analysis for cytokeratin (CK) 20, Ki-67, MUC6, and beta-catenin was performed. Diagnoses were as follows: HP, 6; SSA, 12; HP vs SSA, 3; MSAL, 16; MCA, 14; and CAD, 2. All HPs showed expanded (beyon...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Bellizzi AM, Rock J, Marsh WL, Frankel WL Tags: Am J Clin Pathol Source Type: journals

Reverse transcriptase-polymerase chain reaction as an ancillary molecular technique in the diagnosis of small blue round cell tumors by fine-needle aspiration cytology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We evaluated the feasibility and usefulness of reverse transcriptase-polymerase chain reaction (RT-PCR) on fine-needle aspirates for categorization of small blue round cell tumors (SBRCTs). A total of 51 cases, including 25 Ewing sarcoma/peripheral primitive neuroectodermal tumors (PNETs), 11 rhabdomyosarcomas, 13 neuroblastomas, and 2 desmoplastic small round cell tumors (DSRCTs) were analyzed. The detection of the EWS-FLI1 (20/25) and EWS-ERG (4/25) fusion transcripts resolved 24 of 25 cases of Ewing sarcoma/PNET. The PAX3/7-FKHR fusion transcript was detected in 2 of 4 cases of alveolar rhabdomyosarcoma and the EWS-...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Gautam U, Srinivasan R, Rajwanshi A, Bansal D, Marwaha RK, Vasishtha RK Tags: Am J Clin Pathol Source Type: journals

Presence of tumor-infiltrating lymphocytes and a dominant nodule within primary melanoma are prognostic factors for relapse-free survival of patients with thick (t4) primary melanoma: pathologic analysis of the e1690 and e1694 intergroup trials.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study confirmed the importance of tumor ulceration and the number of positive lymph nodes on outcome. PMID: 20231618 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Rao UN, Lee SJ, Luo W, Mihm MC, Kirkwood JM Tags: Am J Clin Pathol Source Type: journals

Histologic changes associated with neoadjuvant chemotherapy are predictive of nodal metastases in patients with high-risk prostate cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical trials are evaluating the effect of neoadjuvant chemotherapy on men with high-risk prostate cancer. Little is known about the clinical significance of postchemotherapy tumor histopathologic features. We assessed the prognostic and predictive value of histologic features (intraductal carcinoma, vacuolated cell morphologic features, inconspicuous glands, cribriform architecture, and inconspicuous cancer cells) observed in 50 high-risk prostate cancers treated with preprostatectomy docetaxel and mitoxantrone. At a median follow-up of 65 months, the overall relapse-free survival (RFS) rates at 2 and 5 years were 6...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: O'Brien C, True LD, Higano CS, Rademacher BL, Garzotto M, Beer TM Tags: Am J Clin Pathol Source Type: journals

Does the Size Matter?: Prostate Weight Does Not Predict PSA Recurrence After Radical Prostatectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous studies suggest that low prostate weight is a significant negative prognostic factor for prostate cancer. In the current study, the data for 431 men who underwent radical retropubic prostatectomy between 1990 and 1998 were analyzed for association between prostate weight and various clinical and pathologic parameters. These included age, preoperative prostate-specific antigen (PSA) level, PSA recurrence, pathologic stage, Gleason grade, extraprostatic extension, positive surgical margins, tumor volume, associated high-grade prostatic intraepithelial neoplasia, perineural invasion, and lymph node metastasis. Po...
Source: American Journal of Clinical Pathology - March 18, 2010 Category: Pathology Authors: Davidson DD, Koch MO, Lin H, Jones TD, Biermann K, Cheng L Tags: Am J Clin Pathol Source Type: journals

The blood picture and serum biochemistry profile of the African pied crow (Corvus albus)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluated the blood picture (haematology) and serum biochemistry profile of apparently healthy African pied crows trapped in Nsukka, Eastern Nigeria. A total of 25 crows were used for the study, and the evaluation of the blood picture and serum biochemistry profile followed standard procedures. Results obtained for the parameters assessed are summarised as follows (mean ± standard error): packed cell volume (%)—42.85 ± 0.90, haemoglobin concentration (g/dl)—14.09 ± 0.36, red blood cell count (106/ul)—3.15 ± 0.09, mean corpuscular volume (fl)—137.53 ± 4.00, mean corpuscular haemog...
Source: Comparative Clinical Pathology - March 18, 2010 Category: Pathology Tags: Comparative Clinical Pathology Source Type: journals

Relationship between the level of plasma insulin and lipid profile in Iranian fat-tailed sheepEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, variations in the plasma concentration of insulin and its correlation with the plasma cholesterol, triglyceride, high-density lipoprotein (HDL cholesterol), low-density lipoprotein (LDL cholesterol), and very-low-density lipoprotein (VLDL) concentrations were investigated. Blood samples were collected from the jugular vein of 96 clinically healthy, non-pregnant ewes (grouped according to their age 1–3, 3–6, 6–12, 12–24, 24–48, and >48 months) in the autumn months. The level of plasma insulin was determined by chemiluminescence and other parameters were measured by spectrophotometry usi...
Source: Comparative Clinical Pathology - March 18, 2010 Category: Pathology Tags: Comparative Clinical Pathology Source Type: journals

Effect of fresh dietary garlic powder on some of the serum biochemical parameters in broiler chicksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of the present study was to investigate the effect of garlic, in powder form, on protein fractions of broiler chicks' sera. Two hundred and eighty, 2-day-old Ross chicks were randomly divided into four groups: A and B (52 each) and C and D (88 each). The chicks in groups A and B were fed control diet, but those in groups C and D received diet supplemented with 1% and 3% garlic powder, respectively. To evaluate the effect of consumption period of garlic on immune response, half of the chicks in groups C and D were separated after the second bleeding as groups E and F and were fed control diet...
Source: Comparative Clinical Pathology - March 18, 2010 Category: Pathology Tags: Comparative Clinical Pathology Source Type: journals

Cytological findings of mixed squamous cell and glandular papilloma in the lungEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary mixed squamous cell and glandular papilloma is an extremely rare neoplasm. This is the first cytological report of such a rare neoplasm. A 59-year-old Japanese man was admitted to the hospital complaining of a persistent cough and bloody sputum. A bronchial endoscopic examination revealed an endobronchial polypoid tumor. Upon bronchial brush cytology by Papanicolaou stain, squamous dysplasia showing mild atypia was suspected. The smears showed moderate cellularity with singly scattered cells or loose clusters of cells, consisting of squamous cells and a few columnar cells. Nuclei of the squamous cells showed mild...
Source: Diagnostic Cytopathology - March 18, 2010 Category: Pathology Authors: Kyuichi Kadota, Reiji Haba, Naomi Katsuki, Toshitetsu Hayashi, Yumi Miyai, Kenji Bando, Shinsuke Shibuya, Yoshio Kushida Source Type: journals

Cytological diagnosis of actinomycosis and eumycetoma: A report of two casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here two cases: one of eumycetoma and the other of an actinomycosis that were reliably diagnosed with FNAC. The cytological features were similar to histopathology features and differentiated eumycetoma and actinomycosis. FNAC is a rapid, simple and inexpensive outpatient procedure that helps in rapid diagnosis. Diagn. Cytopathol. 2010. © 2010 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - March 18, 2010 Category: Pathology Authors: Mahantappa Hemalata, Sruthi Prasad, Kusuma Venkatesh, S. R. Niveditha, Suja Ajoy Kumar Source Type: journals

Intrathyroidal oncocytic parathyroid adenoma: A diagnostic pitfall on fine-needle aspirationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oncocytic parathyroid adenoma is a rarely seen benign neoplasm of the parathyroid and intrathyroidal location of this lesion is also uncommon. It can be easily misdiagnosed as Hürthle cell thyroid neoplasm on fine-needle aspiration (FNA). Here, an intrathyroidal oncocytic parathyroid adenoma in a 32-year-old male is reported. Ultrasonography showed a nodule 2 cm in largest diameter in the left thyroid lobe. FNA revealed cellular smears containing monotonous oncocytic cells arranged in monolayered sheets, pseudopapillary structures and clusters within a rich vascular network. The case was reported as "suspicious for Hürth...
Source: Diagnostic Cytopathology - March 18, 2010 Category: Pathology Authors: Irem Paker, Demet Yilmazer, Kemal Yandakci, Ata Turker Arikok, Murat Alper Source Type: journals

Cytopathological features of warty (condylomatous) carcinoma of the penis: A case report and distinction from other verruciform penile tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Warty (condylomatous) carcinoma (WC) is a rare specific variant of invasive squamous cell carcinoma that shows hybrid features of condyloma with invasive cell carcinoma. As compared with conventional squamous cell carcinoma, WC tends to run a less aggressive clinical course. A case is presented here in which squash smears of a penile foreskin tumor in a 65-year-old male revealed small cohesive clusters and sheets of tumor cells in papillary configurations. The neoplastic cells were polygonal to elongated and contained oval nuclei, coarse chromatin pattern, and distinct nucleoli. Nuclear pleomorphism and loss of nuclear pol...
Source: Diagnostic Cytopathology - March 18, 2010 Category: Pathology Authors: Toshitetsu Hayashi, Reiji Haba, Yoshio Kushida, Kyuichi Kadota, Naomi Katsuki, Yumi Miyai, Kenji Bando, Shinsuke Shibuya, Yasunobu Funamoto, Yoshiyuki Kakehi Source Type: journals

Large pulmonary cryptococcoma and cryptococcal meningitis in an immunocompetent patient: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary cryptococcoma is a life threatening mycosis and is an unusual disease for immunocompetent individuals. Herein we report a case of large pulmonary cryptococcoma associated with cryptococcal meningitis, presenting radiologically as a lung mass in right upper lobe, in a previously healthy, HIV negative, immunocompetent young individual. Since cryptococcosis continues to be an important infection in HIV negative patients and is associated with substantial overall and cause-specific mortality, the need for consideration of this entity in the differential diagnosis of a lung mass is emphasized. Diagn. Cytopathol. 2010....
Source: Diagnostic Cytopathology - March 18, 2010 Category: Pathology Authors: Ranbeer Singh, Deepti Joshi, Anupama Gupta, Nitin Gangane Source Type: journals

Papanicolaou stain may not be necessary in majority of head and neck fine-needle aspirations: Evidence from a correlation study between Diff-Quik-based onsite diagnosis and final diagnosis in 287 head and neck fine-needle aspirationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to evaluate the degree of correlation between Diff-Quik-based onsite diagnosis (OD) and final diagnosis (FD) and further improve the efficiency of FNA practice.Two hundred and eighty-seven cytopathologist-performed FNAs from the head and neck region were evaluated. Number of passes, number and type of slides and correlation (agreement, modified final diagnosis and disagreement) between OD and FD were evaluated.Among 287 FNAs, the average number of passes per FNA case was 2 (range, 1-5). The mean number of slides reviewed per case was 5 including 2 Diff-Quik (D-Q)-stained slides, 2 Papanicolao...
Source: Diagnostic Cytopathology - March 18, 2010 Category: Pathology Authors: Maoxin Wu, Muhammad Idrees, Zhengbin Zhang, Eric Genden, David E. Burstein Source Type: journals

Making the diagnosis with only two levels of nongynecologic cell blocks as opposed to three is more cost effectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two hundred forty-three of 246 cases in phase I (98.8%) and 246 of 247 cases in phase II (99.6%) had adequate or the same material present on the level two cell blocks. Sixty-nine cases were malignant (28.1%), 20 were atypical (8.1%), 157 were benign (63.8), and 16 were signed out on the cell block only (6.5%) in phase I. In phase II, 69 (27.9%) cases were malignant, 22 (8.9%) were atypical, 156 (63.2%) were benign, and 18 (7.3%) were signed out based on material present in the cell block. Fifteen cases in phase I (6.1%) and 17 (6.9%) in phase II needed immunohistochemical staining for further evaluation. Twenty-four upper...
Source: Diagnostic Cytopathology - March 18, 2010 Category: Pathology Authors: Gina Zanchelli-Astran, Moira Wood, Marluce Bibbo Source Type: journals

Human Papillomavirus DNA and Oncogene Alterations in Colorectal Tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates HPV DNA and viral integration in colorectal tumors, suggesting a potential role of this virus in colorectal carcinogenesis. There was no concurrence, however, of k-ras and c-myc activation with viral infection. PMID: 20232185 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - March 17, 2010 Category: Pathology Authors: Pérez LO, Barbisan G, Ottino A, Pianzola H, Golijow CD Tags: Pathol Oncol Res Source Type: journals

Diagnostic approach to pancreatic tumors with the specimens of endoscopic ultrasound-guided fine needle aspirationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has enabled clinicians to histologically diagnose pancreatic tumors. However, EUS-FNA specimens often result in tiny fragmented tissues, so auxiliary utilities are necessary. Using immunostaining of CK7, CDX2, neuroendocrine markers and KRAS mutation analysis, we examined 57 FNA cell block sections and 61 surgically-resected specimens (25 invasive ductal carcinomas, 25 endocrine tumors, and 11 acinar cell tumors). In the majority of the matched pairs, the diagnoses between EUS-FNA and surgical specimens were concordant using the following criteria: neuroendocrin...
Source: Pathology International - March 17, 2010 Category: Pathology Authors: Waki Hosoda, Tadayuki Takagi, Nobumasa Mizuno, Yasuhiro Shimizu, Tsuyoshi Sano, Kenji Yamao, Yasushi Yatabe Source Type: journals

Histopathologic findings of transbronchial biopsy in usual interstitial pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, it cannot be claimed that transbronchial biopsy is more useful in confirming usual interstitial pneumonia than previously recognized. The primary and main role of transbronchial biopsy in diagnosis of usual interstitial pneumonia is thought not to confirm a diagnosis, but to exclude other infiltrative diseases, such as malignancy, sarcoidosis or infections. (Source: Pathology International)
Source: Pathology International - March 17, 2010 Category: Pathology Authors: Hyo Sup Shim, Moo Suk Park, In Kyu Park Source Type: journals

Monolobar ductal plate malformation disease of the liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We herein report a unique monolobar hepatic disease composed of Caroli's disease, peribiliary cysts, ductal plate malformations, peribiliary gland proliferation, hepatolithiasis, and portal phlebosclerosis with thrombi. A 73-year-old man underwent abdominal imaging, which revealed multiple segmental dilations of the left intrahepatic bile ducts. Polycystic kidney diseases were absent. Intrahepatic cholangiocarcinoma was suspected, and extended left lobectomy of the liver was preformed. Grossly, the hepatic left lobe was atrophic, and partly replaced by fibrous tissue. The intrahepatic bile ducts were dilated (Caroli's dise...
Source: Pathology International - March 17, 2010 Category: Pathology Authors: Tadashi Terada, Toshiaki Moriki Source Type: journals

March 16, 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW Real Transformation Story – Observations from the juncture where computers and medicine intersect (Source: CAP Transformation of the Pathology Specialty)
Source: CAP Transformation of the Pathology Specialty - March 16, 2010 Category: Pathology Source Type: organizations

Encapsulated Stem Cells Treat Peripheral Arterial Disease in RabbitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
By cloaking stem cells in an alginate capsule along with a radiologic contrast agent, researchers have created "microbubbles" that enhance the cells' viability and improve blood flow in a rabbit model of peripheral arterial disease. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 16, 2010 Category: Pathology Tags: Radiology Source Type: info