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Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeabilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractAppreciation of the glomerular microcirculation as a specialized microcirculatory bed, rather than as an entirely separate entity, affords important insights into both glomerular and systemic microvascular pathophysiology. In this review we compare regulation of permeability in systemic and glomerular microcirculations, focusing particularly on the role of the endothelial glycocalyx, and consider the implications for disease processes. The luminal surface of vascular endothelium throughout the body is covered with endothelial glycocalyx, comprising surface‐anchored proteoglycans, supplemented with adsorbed solubl...
Source: The Journal of Pathology - February 3, 2012 Category: Pathology Authors: Andrew HJ SalmonSimon C Satchell Tags: Invited Review Source Type: research

An osteosarcoma zebrafish model implicates Mmp‐19 and Ets‐1 as well as reduced host immune response in angiogenesis and migrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractAbout 40% of osteosarcoma patients die of metastases. Novel strategies to improve treatment of metastatic patients require a better understanding of the processes involved, like angiogenesis, migration and the immune response. However the rarity of osteosarcoma and its heterogeneity make this neoplasm difficult to study. Recently we reported malignant transformation of mouse mesenchymal stem cells (MSCs) which formed osteosarcoma upon transplantation into mice. Here we studied these cells in zebrafish embryos and found that transformed MSCs induced angiogenesis and migrated through the bodies of the embryos, but th...
Source: The Journal of Pathology - February 3, 2012 Category: Pathology Authors: Alexander B. MohsenyWei XiaoRalph CarvalhoHerman P. SpainkPancras C.W. HogendoornAnne‐Marie Cleton‐Jansen Tags: Original Paper Source Type: research

STATLINE Issue February 2, 2012Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In This Issue: Registration Is Now Open for 2012 CAP Policy Meeting - PTO Seeks Public Input on Genetic Diagnostic Testing - Congress Returns to Work on SGR, Other Key Issues - PCORI Releases Draft Priorities For Comparative Effectiveness Research - AMA Lobbies to Delay ICD-10 Implementation (Source: STATLINE Federal and State News Briefs)
Source: STATLINE Federal and State News Briefs - February 2, 2012 Category: Pathology Source Type: news

Conquering Atherosclerosis Starts With Improving Medical EducationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The United States Department of Health and Human Services recently launched the Million Hearts initiative to prevent 1 million heart attacks and strokes over the next 5 years by implementing proved, effective, and inexpensive interventions. But why stop at a million? We already have all the information we need to eradicate atherosclerotic disease, which is a food-borne illness. Coronary artery disease is virtually nonexistent in large populations of individuals who consume plant-based nutrition. Some of the most renowned cardiovascular pathologists in the world have stated that maintaining a total cholesterol level >150 mg...
Source: The American Journal of Cardiology - February 2, 2012 Category: Cardiology Authors: Michael A. Kadoch Tags: Readers' Comments Source Type: research

EGFR, CD10 and proliferation marker Ki67 expression in Ameloblastoma: possible role in local recurrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Evaluation of CD10 and Ki67 status together with conventional histological evaluation can help in providing more information about the biologic behavior of the tumor, while EGFR could be a target of an expanding class of anticancer therapies.Since ameloblastomas are EGFR-positive tumors, anti-EGFR agents could be considered to reduce the size of large tumors and to treat unresectable tumors that are in close proximity to vital structures. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 2, 2012 Category: Pathology Authors: Azza Abdel-AzizMaha Amin Source Type: research

Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endotheliumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The core pathology of sickle cell disease (SCD) starts with the erythrocyte (RBC). Aberration in MAPK/ERK1/2 signaling, which can regulate cell adhesion, occurs in diverse pathologies. Because RBCs contain abundant ERK1/2, we predicted that ERK1/2 is functional in sickle (SS) RBCs and promotes adherence, a hallmark of SCD. ERK1/2 remained active in SS but not normal RBCs. β2-adrenergic receptor stimulation by epinephrine can enhance ERK1/2 activity only in SS RBCs via PKA- and tyrosine kinase p72syk-dependent pathways. ERK signaling is implicated in RBC ICAM-4 phosphorylation, promoting SS RBC adhesion to the endothel...
Source: Blood - February 2, 2012 Category: Hematology Authors: Zennadi, R., Whalen, E. J., Soderblom, E. J., Alexander, S. C., Thompson, J. W., Dubois, L. G., Moseley, M. A., Telen, M. J. Tags: Red Cells, Iron, and Erythropoiesis Source Type: research

AlloDerm and DermaMatrix implants for parotidectomy reconstruction: A histologic study in the rat modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionsAlloDerm reacts similarly when comparing the postparotidectomy bed to the dorsum. DermaMatrix induces a more marked inflammatory reaction in the postparotidectomy bed when compared with the dorsum. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)
Source: Head and Neck - February 2, 2012 Category: ENT & OMF Authors: Sanjay M. AthavaleSanjeet RangarajanLatif DharamsiSabrina WentzSharon PhillipsTheodore McRackanWendell G. Yarbrough Tags: Original Article Source Type: research

Hyalinizing clear cell adenocarcinoma of the oropharynxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionImmunohistochemical staining is essential for narrowing the differential diagnosis of these lesions. Treatment is controversial but usually consists of wide local excision and possibly a neck dissection. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)
Source: Head and Neck - February 2, 2012 Category: ENT & OMF Authors: Eelam AdilDhave SetabutrKael MikesellDavid Goldenberg Tags: Case Report Source Type: research

2/7 Seminars in Oncology: "Deconstructing the Molecular Genetics of Human Cancer, and its Therapeutic Implications"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Speaker: Pier Paolo Pandolfi, MD, PhD George C. Reisman Professor of Medicine and Pathology Harvard Medical School Beth Israel Deaconess Medical Center Boston, MA Tuesday, February 7, 2012 4 p.m. Jimmy Fund Auditorium Hosted by: Kornelia Polyak, MD, PhD 617-582-7646 (Source: DF/HCC: Latest News)
Source: DF/HCC: Latest News - February 1, 2012 Category: Cancer & Oncology Tags: Announcements Source Type: news

Could lack of vitamin D be behind Sids cases? (BBC Radio 4 The Today Programme, 26 January 2012)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pathologists have voiced concerns that a number of infant deaths may have been due to vitamin D deficiency. Interview on the Today Programme In related news, Professor Dame Sally Davies, chief medical officer for England, has announced that she will be raising awareness of vitamin D deficiency among doctors and the public as a priority. Full article (BBC News Online, 24 January 2012) (Source: Society for Endocrinology)
Source: Society for Endocrinology - February 1, 2012 Category: Endocrinology Source Type: news

Cafe Scientifique: Alzheimer’s disease – a quest for a cure (2012-02-09)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the IoP Cafe Scientifique is to get the South London community in contact with scientists and clinicians at the Institute of Psychiatry in a relaxed atmosphere, encouraging the exchange of knowledge, ideas and science. Dr Amy Pooler, an expert on Alzheimer’s disease, will explain the pathology of this devastating disorder as well as highlight current therapies and research advances in (Source: Institute of Psychiatry | Events)
Source: Institute of Psychiatry | Events - February 1, 2012 Category: Psychiatry Tags: other Source Type: news

Worldwide variations in EGFR somatic mutations: a challenge for personalized medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two studies recently reported around 10% of EGFR activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients. Like in lung cancer, the EGFR mutation profiles seem to be related to the ethnical origin of patients. This is an important point that should be considered when developing anti-EGFR therapies. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 1, 2012 Category: Pathology Authors: Pierre-Jean LamyWilliam Jacot Source Type: research

Malignant biphasic peritoneal mesothelioma in a child: Consideration of other diagnostic possibilitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - February 1, 2012 Category: Pathology Authors: Stanley J. Geyer Tags: Letter to the Editor Source Type: research

Mediastinal seminoma: A case report with special emphasis on sall4 as a new immunocytochemical markerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of mediastinal seminoma diagnosed intraoperatively by cytological examination of cystic fluid containing tumor cells.An anterior mediastinal tumor with cystic component was incidentally found in a 28‐year‐old Japanese male. Cytological examination of the cystic fluid at the time of tumor resection showed single and loose aggregates of large round to polygonal cells with large round nuclei, vesicular chromatin and nucleoli, and mild to moderate amounts of PAS‐positive cytoplasm admixed with mature lymphocytes. A diagnosis of seminoma was made intraoperatively. On subsequent immunostaining, the tumor c...
Source: Diagnostic Cytopathology - February 1, 2012 Category: Pathology Authors: Nozomi IwamotoMitsuaki IshidaKeiko YoshidaAkiko KagotaniMuneo IwaiHidetoshi Okabe Tags: Brief Report Source Type: research

Response to Article: “Lang TU et al. Molluscum Contagiosum of the Cervix.”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - February 1, 2012 Category: Pathology Authors: Akosua DomfehLiming HaoVinita Parkash Tags: Letter to the Editor Source Type: research

Aspiration cytology of mesenchymal hamartoma of the liver: Report of a Case and Review of LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - February 1, 2012 Category: Pathology Authors: Ruchika GuptaRicha GuptaKalpana BansalAnup Mohta Tags: Images in Cytology Source Type: research

Erythroblastosis in the peritoneal fluid of a newbornEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - February 1, 2012 Category: Pathology Authors: David M. TassoKarla K. DunningRobert W. McKennaStefan E. Pambuccian Tags: Images in Cytology Source Type: research

Endobronchial ultrasound‐guided transbronchial needle aspiration diagnosis of mediastinal lymph node metastasis of mucinous adenocarcinoma: Arborizing Stromal Meshwork Fragments as a Diagnostic ClueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the cytopathologic findings of a case of metastatic signet‐ring cell carcinoma with abundant extracellular mucin production in the mediastinal lymph nodes of a 41‐year‐old woman, who presented with nausea, abdominal pain, and weight loss. Imaging studies showed a renal mass, numerous lung nodules, and mediastinal and retroperitoneal lymphadenopathy. EBUS‐TBNA of level 4R and 7 lymph nodes showed abundant, thick, “clean” mucus with entrapped ciliated bronchial cells, rare histiocytes, and fragments of cartilage. No neoplastic cells could be identified in Diff‐Quik®‐stained smears during the rapid ...
Source: Diagnostic Cytopathology - February 1, 2012 Category: Pathology Authors: Arbaz SamadJustin C. PeltolaMohi O. MitiekJose JessurunJ. Carlos ManivelStefan E. Pambuccian Tags: Brief Report Source Type: research

Fine needle aspiration of intrapancreatic accessory spleen: Cytomorphologic features and differential diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS:Diagnostic pitfalls include pancreatic neuroendocrine tumor. If IPAS is recognized as a diagnostic consideration on EUS‐FNA, unnecessary surgical resection may be avoided. Cancer (Cancer Cytopathol) 2012. © 2012 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 1, 2012 Category: Pathology Authors: Armanda D. TatsasChristopher L. OwensMomin T. SiddiquiRalph H. HrubanSyed Z. Ali Tags: Original Article Source Type: research

Arginase‐1: A novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION:This study demonstrates that both arginase‐1 and HepPar‐1 are effective IHC markers of hepatocellular differentiation. Furthermore, arginase‐1 demonstrates superior sensitivity compared with GPC‐3 and HepPar‐1 in the diagnosis of HCC, whereas GPC‐3 demonstrates superior specificity, as staining is not observed in benign hepatocellular lesions. Hence, use of arginase‐1 with HepPar‐1 and GPC‐3 can aid in the diagnosis of HCC and separating from metastatic carcinoma. Cancer (Cancer Cytopathol) 2012. © 2012 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 1, 2012 Category: Pathology Authors: Ryan McKnightAziza NassarCynthia CohenMomin T. Siddiqui Tags: Original Article Source Type: research

Cytopathology of cervical mesonephric adenocarcinoma: a report of two casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cytopathology)
Source: Cytopathology - February 1, 2012 Category: Pathology Authors: K. NomotoS. HayashiK. TsuneyamaT. HoriS. Ishizawa Tags: CASE REPORT Source Type: research

Improved clonality detection in Hodgkin lymphoma using the BIOMED‐2‐based heavy and kappa chain assay: a paraffin‐embedded tissue studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:  Combined study of IGH and IGK rearrangement according to BIOMED‐2 protocols improves clonality detection rate (up to 25% of cases) in HL, even when working on non‐microdissected FFPE tissue. (Source: Histopathology)
Source: Histopathology - February 1, 2012 Category: Pathology Authors: Gustavo TapiaCarolina SanzJosé L MateAna M Muñoz‐MármolAurelio Ariza Source Type: research

Differential expression of forkhead box M1 and its downstream cyclin‐dependent kinase inhibitors p27kip1 and p21waf1/cip1 in the diagnosis of pulmonary neuroendocrine tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:  FoxM1, p27kip1 and p21waf1/cip1 showed distinct immunoreactivity according to histological subtype, which may be of value as an ancillary test in the differential diagnosis of pulmonary NE tumours. (Source: Histopathology)
Source: Histopathology - February 1, 2012 Category: Pathology Authors: Seung Yeon HaChang Hun LeeHee Kyung ChangSunhee ChangKun Young KwonEun Hee LeeMee Sook RohBoram Seo Source Type: research

Expression of vascular Notch ligands Delta‐like 4 and Jagged‐1 in glioblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:  In summary, Dll4 and Jag1 are expressed in glioblastoma vasculature. These data may define subsets of glioblastoma that might be sensitive (Dll4+/Jag1+) or resistant (Dll4+/Jag1–) to bevacizumab. Our data also suggest that anti‐Dll4 therapy should be evaluated experimentally in glioblastoma. (Source: Histopathology)
Source: Histopathology - February 1, 2012 Category: Pathology Authors: Adrian M JubbLisa BrowningLeticia CampoHelen TurleyGraham SteersGavin ThurstonAdrian L HarrisOlaf Ansorge Source Type: research

ImmunoMembrane: a publicly available web application for digital image analysis of HER2 immunohistochemistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:  We anticipate that publicly available web applications, such as ImmunoMembrane, will accelerate the adoption of automated image analysis in clinical diagnostics of HER2 IHC. ImmunoMembrane is freely accessible at: http://jvsmicroscope.uta.fi/immunomembrane/. (Source: Histopathology)
Source: Histopathology - February 1, 2012 Category: Pathology Authors: Vilppu J TuominenTeemu T TolonenJorma Isola Source Type: research

The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumourEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:  This suggests that, despite their similar morphological appearances, the GCT‐like component of gynandroblastoma has a different molecular basis from conventional adult‐type GCT. This finding underscores a more general principle that morphological similarity does not necessarily indicate molecular identity. (Source: Histopathology)
Source: Histopathology - February 1, 2012 Category: Pathology Authors: Richard OparkaAndrew CassidyStephanie ReillyAlasdair StenhouseW Glenn McCluggageC Simon Herrington Tags: SHORT REPORT Source Type: research

An analysis of five clear cell papillary cystadenomas of mesosalpinx and broad ligament: four associated with von Hippel‐Lindau disease and one aggressive sporadic typeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:  The VHLD‐associated cases appeared to be benign, but the sporadic case exhibited a low malignant potential. CCPCs show histological and immunophenotypical similarities with the recently reported clear cell papillary RCC, although the previously unreported apical CD10 and nuclear PAX2 expression may be related to their mesonephric origin. CCPC has a distinctive sub‐epithelial vascular pattern that is consistent with its pathogenesis. (Source: Histopathology)
Source: Histopathology - February 1, 2012 Category: Pathology Authors: Francisco F NogalesPablo GoyenagaOvidiu PredaAlina NicolaeBegoña VieitesMaria Carmen Ruiz‐MarcellanAlberto PedrosaMaria J Merino Source Type: research

Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria‐related appendicitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:  Our data demonstrate that bacteria‐related active inflammation results in a sharp increase of DMBT1 levels in enterocytes. These findings substantiate the view that DMBT1 is of functional relevance for host defence and modulation of the course of intestinal bacteria‐related inflammatory responses. (Source: Histopathology)
Source: Histopathology - February 1, 2012 Category: Pathology Authors: Elke KaemmererUrsula SchneiderChristina KlausPatrick PlumAndrea ReinartzMaximilian AdolfMarcus RennerTim G A M WolfsBoris W KramerNorbert WagnerJan MollenhauerNikolaus Gassler Source Type: research

Cancer‐associated fibroblasts and CD163‐positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:  Cancer‐associated fibroblasts and CD163‐positive macrophages may be potential prognostic predictors of OSCC. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - February 1, 2012 Category: Pathology Authors: Nobuyuki FujiiKohei ShomoriTatsushi ShiomiMotoki NakabayashiChikako TakedaKazuo RyokeHisao Ito Source Type: research

Global histone modification pattern associated with recurrence and disease‐free survival in non‐small cell lung cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our data suggest that global histone H3 and H4 modification patterns are potential markers of tumor recurrence and disease‐free survival in NSCLC patients. (Source: Pathology International)
Source: Pathology International - February 1, 2012 Category: Pathology Authors: Joon Seon SongYong Seok KimDong Kwan KimSung il ParkSe Jin Jang Source Type: research

Lipid Management in High Risk Coronary Patients: How Effective are We at Secondary Intervention?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: To assess the proportion of patients who achieve and maintain target lipid levels during optimum long term follow up after coronary bypass surgery.Methods: From a prospectively compiled database, we identified 440 patients followed for up to 13 years after CABG as part of a radial artery randomised controlled trial. All available lipid assays conducted during the follow-up period were collected from pathology databases. These were used to calculate the annualised mean lipid exposure for each patient. Based upon National Heart Foundation guidelines, we determined the proportion of patients whose mean lipid exposu...
Source: Heart, Lung and Circulation - February 1, 2012 Category: Cardiology Authors: Ying Yan Zhu, Philip A.R. Hayward, David L. Hare, Andrew G. Stewart, Brian F. Buxton Tags: Original Articles Source Type: research

Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: uPA and PAI-1 concentrations in ND were higher in women with atypia and cancer compared to women with benign disease. Combining uPA, PAI-1 and TF in the assessment of women requiring diagnostic breast surgery maximized disease prediction. The assessment of these markers may prove useful in early breast cancer detection. (Source: BMC Cancer)
Source: BMC Cancer - February 1, 2012 Category: Cancer & Oncology Authors: Wenyi QinGerald GuiKe ZhangDominique TwelvesBeth KliethermesEdward Sauter Source Type: research

Autophagy guards against Cisplatin-induced acute kidney injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, autophagy guards kidney proximal tubules against AKI, possibly by alleviating DNA damage and reactive oxygen species production and by eliminating toxic protein aggregates. Enhancing autophagy may provide a novel therapeutic option to minimize AKI. PMID: 22265049 [PubMed - in process] (Source: The American Journal of Pathology)
Source: The American Journal of Pathology - February 1, 2012 Category: Pathology Authors: Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y, Rakugi H Tags: Am J Pathol Source Type: research

Targeted Deletion of Jun/AP-1 in Alveolar Epithelial Cells Causes Progressive Emphysema and Worsens Cigarette Smoke-Induced Lung Inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we report decreased expression levels of c-Jun mRNA and protein in the lung tissues of patients with advanced chronic obstructive pulmonary disease, and the genetic deletion of c-Jun specifically in alveolar epithelial cells causes progressive emphysema with lung inflammation and alveolar air space enlargement, which are cardinal features of emphysema. Although mice lacking c-Jun specifically in lung alveolar epithelial cells appear normal at the age of 6 weeks, when exposed to long-term cigarette smoke, c-Jun-mutant mice display more lung inflammation with perivascular and peribronchiolar infiltrates compar...
Source: The American Journal of Pathology - February 1, 2012 Category: Pathology Authors: Reddy NM, Vegiraju S, Irving A, Paun BC, Luzina IG, Atamas SP, Biswal S, Ana NA, Mitzner W, Reddy SP Tags: Am J Pathol Source Type: research

Antinuclear Antibodies as Markers in Biliary CirrhosisAntinuclear Antibodies as Markers in Biliary CirrhosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The serological hallmark of primary biliary cirrhosis is presence of antimitochondrial antibodies, but evidence is strong that antinuclear antibodies also show diagnostic and clinical significance. Expert Review of Molecular Diagnostics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 31, 2012 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Newspath February, 2012 - Chronic Traumatic Encephalopathy—A Neurodegenerative Disease Caused by Brain InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic traumatic encephalopathy is a neurodegenerative disease induced by repeated blows to the head. Clinically, it is characterized by cognitive decline, mood disorders, and parkinsonism. (Source: NewsPath - Pathology News for the Medical Community)
Source: NewsPath - Pathology News for the Medical Community - January 31, 2012 Category: Pathology Source Type: news

CAP/ASCCP Lower Anogenital Squamous Terminology Standardization ProjectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A joint collaboration with the American Society for Colposcopy and Cervical Pathology in an effort to harmonize terminology. (Source: CAP Important Announcements and News)
Source: CAP Important Announcements and News - January 31, 2012 Category: Pathology Source Type: news

Register for the 2012 CAP Policy MeetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New this year—take advantage of this free opportunity to earn 7.25 AMA PRA Category 1 Credits(TM) by attending the May 7-9 meeting in Washington, D.C. (Source: CAP Important Announcements and News)
Source: CAP Important Announcements and News - January 31, 2012 Category: Pathology Source Type: news

The CAP Abstract Submission Site is Now OpenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is your opportunity to have your original research published in the Archives of Pathology & Laboratory Medicine and present your poster at CAP ’12. (Source: CAP Important Announcements and News)
Source: CAP Important Announcements and News - January 31, 2012 Category: Pathology Source Type: news

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Uncontrolled endoplasmic reticulum (ER) stress responses are proposed to contribute to the pathology of chronic inflammatory diseases such as type 2 diabetes or atherosclerosis. However, the connection between ER stress and inflammation remains largely unexplored. Here, we show that ER stress causes activation of the NLRP3 inflammasome, with subsequent release of the pro-inflammatory cytokine interleukin-1β. This ER-triggered proinflammatory signal shares the same requirement for reactive oxygen species production and potassium efflux compared with other known NLRP3 inflammasome activators, but is indepen...
Source: Atherosclerosis - January 31, 2012 Category: Cardiology Authors: Menu P, Mayor A, Zhou R, Tardivel A, Ichijo H, Mori K, Tschopp J Tags: Cell Death Dis Source Type: research

How to write an article: Preparing a publishable manuscript!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vinod B Shidham, Martha B Pitman, Richard M DeMayCytoJournal 2012 9(1):1-1Most of the scientific work presented as abstracts (platforms and posters) at various conferences have the potential to be published as articles in peer-reviewed journals. This DIY (Do It Yourself) article on how to achieve that goal is an extension of the symposium presented at the 36 th European Congress of Cytology, Istanbul, Turkey (presentation available on net at http://alturl.com/q6bfp). The criteria for manuscript authorship should be based on the ICMJE (International Committee of Medical Journal Editors) Uniform Requirements for Manuscripts....
Source: CytoJournal - January 31, 2012 Category: Pathology Authors: Vinod B ShidhamMartha B PitmanRichard M DeMay Source Type: research

Comparing endobronchial ultrasound-guided fine needle aspiration specimens with and without rapid on-site evaluationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sara E Monaco, Liron Pantanowitz, Walid E KhalbussCytoJournal 2012 9(1):2-2 (Source: CytoJournal)
Source: CytoJournal - January 31, 2012 Category: Pathology Authors: Sara E MonacoLiron PantanowitzWalid E Khalbuss Source Type: research

Authors' ReplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adrienne Carruth Griffin, Lauren Ende Schwartz, Zubair BalochCytoJournal 2012 9(1):3-3 (Source: CytoJournal)
Source: CytoJournal - January 31, 2012 Category: Pathology Authors: Adrienne Carruth GriffinLauren Ende SchwartzZubair Baloch Source Type: research

Comparative evaluation of the modified Scarff-Bloom-Richardson grading system on breast carcinoma aspirates and histopathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion : This prospective study shows that FNA smears from peripheral portion of the lesion are representative of the corresponding histopathological sections and it is possible to score and grade by SBR system on FNA smears. (Source: CytoJournal)
Source: CytoJournal - January 31, 2012 Category: Pathology Authors: Cherry BansalUS SinghSanjeev MisraKiran Lata SharmaVandana TiwariAN Srivastava Source Type: research

Predicting Story Goodness Performance from Cognitive Measures following Traumatic Brain Injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The cognitive variables predicted performance on the SGI measures although there were differences in the amount of explained variance. The results suggest that storytelling ability draws upon a number of underlying skills and underscore the importance of using discrete cognitive tasks rather than broad cognitive indices in investigating the cognitive substrates of discourse. PMID: 22294408 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - January 31, 2012 Category: Speech Therapy Authors: Lê K, Coelho C, Mozeiko J, Krueger F, Grafman J Tags: Am J Speech Lang Pathol Source Type: research

Constrained vs. Unconstrained Intensive Language Therapy in Two Individuals with Chronic, Moderate-to-Severe Aphasia and Apraxia of Speech: Behavioral and fMRI Outcomes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Participants accurately produced more target words post-CIAT than post-PACE. Behavioral and fMRI results support the notion that the intense and repetitive nature of obligatory speech production in CIAT has a positive effect on word retrieval, even in chronic moderate-to-severe aphasia with co-morbid AOS. PMID: 22294409 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - January 31, 2012 Category: Speech Therapy Authors: Kurland J, Pulvermüller F, Silva N, Burke K, Andrianopoulos M Tags: Am J Speech Lang Pathol Source Type: research

A comparison of intention and pantomime gesture treatment for noun retrieval in people with aphasia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: IGT and PGT had positive treatment effects, but for contrasting communication modalities. Two individuals with mild-moderate aphasia improved verbal production for both IGT and PGT, while pantomime treatment led to improved gesture use in two individuals with severe aphasia. PMID: 22294410 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - January 31, 2012 Category: Speech Therapy Authors: Ferguson NF, Evans K, Raymer AM Tags: Am J Speech Lang Pathol Source Type: research

Effects of Word Frequency and Modality on Sentence Comprehension Impairments in People with Aphasia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The results show that sentence comprehension in people with aphasia is influenced by word frequency and presentation modality. PMID: 22294411 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - January 31, 2012 Category: Speech Therapy Authors: Dede G Tags: Am J Speech Lang Pathol Source Type: research

Short form Philadelphia Naming Test: Rationale and Empirical Evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The short forms can be used to reliably estimate PNT performance, and the results can be compared to the provided norms. The two matched tests allow for measurement of change in naming ability. PMID: 22294412 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - January 31, 2012 Category: Speech Therapy Authors: Walker GM, Schwartz MF Tags: Am J Speech Lang Pathol Source Type: research

Eye Pathology: An Atlas and TextEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
© 2012 The Authors. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - January 31, 2012 Category: Neurology Authors: Mark Walker Source Type: research