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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 23.

An unusual case of giant cell myocarditis missed in a Heartmate-2 left ventricle apical-wedge section: a case report and review of the literature
Herein we present a case of fulminant myocarditis in a woman previously treated for B-cell lymphoma. While the clinical context was suggestive of adriamycin-induced cardiomyopathy, the initial pathology of the Heartmate-2 apical core showed lymphocytic myocarditis. After 8 months of stability, the patient presented with progressive heart failure and recurrent ventricular arrhythmias. An endomyocardial biopsy revealed findings typical of giant cell myocarditis (GCM); poor response to immunosuppressive therapy and marked hemodynamic instability led to urgent transplantation. To our knowledge, this is the first reported case ...
Source: Journal of Cardiothoracic Surgery - January 17, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kim AndersonMichel CarrierPhilippe RomeoGuy PelletierMark LiszkowskiNormand RacineMichel WhiteAnique Ducharme Source Type: research

Molecular diagnostics complementing morphology in superficial mesenchymal tumors
Molecular techniques are increasingly important in the practice of surgical pathology. In soft tissue tumors, there are a number of tumors with recurring cytogenetic abnormalities. Knowledge of these abnormalities has furthered our understanding of these tumors and has also allowed development of molecular techniques to aid in the diagnosis. This review will focus on mesenchymal tumors with specific cytogenetic abnormalities that may present as a superficial tumor of the dermis or subcutis.
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: Alison L. Cheah, John R. Goldblum, Steven D. Billings Source Type: research

Superficial small round-cell tumors with special reference to the Ewing's sarcoma family of tumors and the spectrum of differential diagnosis
Superficial/cutaneous small round-cell tumors comprise a heterogeneous group of neoplasms including sarcoma, carcinoma, melanoma, and lymphomas. Among superficial sarcomas, the Ewing's sarcoma family of tumors (ESFT) represents a poorly understood rare variant, having a behavioral difference characterized by a relative favorable prognosis. Several problems are still to be resolved in superficial ESFT, including the differential diagnosis between ESFT of bone (intraosseous or periosteal) with superficial infiltration and superficial ESFT with bone infiltration, especially in the fingers. Our aim is to review the most common...
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: Isidro Machado, Victor Traves, Julia Cruz, Beatriz Llombart, Samuel Navarro, Antonio Llombart-Bosch Source Type: research

Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor
This article reviews the clinical and pathologic features and differential diagnoses of atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelioma, myopericytoma, and perivascular epithelioid cell tumor.
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: Cyril Fisher Source Type: research

Nonepithelial skin tumors with multinucleated giant cells
Recognition of the different types of multinucleated giant cells in neoplastic and pseudotumoral lesions of the skin may be helpful in the differential diagnosis of these tumors. In this review, we will analyze the different types of multinucleated giant cells that can be found in nonepithelial cutaneous tumors and, more importantly, the clinicopathological context in which they are found. Touton giant cells are typically present in juvenile xanthogranuloma, necrobiotic xanthogranuloma, and some subtypes of xanthomas. Giant cells with a ground glass appearance are typically present in the solitary reticulohistiocytoma and ...
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: María del Carmen Gómez-Mateo, Carlos Monteagudo Source Type: research

Benign cutaneous neural tumors
Benign cutaneous neural neoplasms are one of the most frequent benign mesenchymal tumors in the skin. Because peripheral sheath nerve is composed of different cells, the tumors raised in these structures are varied and usually contain many of these cells. Most of these tumors are easy to diagnose, as usually present characteristic features well-recognized and express -specific immunohistochemical proteins. However, there are so many infrequent variants that many times require distinction from others spindle-cell tumors including melanoma. The tumors differ from one another by displaying a different proportion and arrangeme...
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: José Luis Rodríguez-Peralto, Erica Riveiro-Falkenbach, Rosario Carrillo Source Type: research

Hemangioendothelioma
is the term used to name those vascular neoplasms that show a borderline biological behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. Although originally spindle cell hemangioendothelioma was proposed as a specific clinicopathologic variant of hemangioendothelioma, currently, it is considered as an entirely benign lesion, and thus, the name spindle cell hemangioma seems to be the most accurate for this lesion. Authentic hemangioendotheliomas involving the skin and soft tissues include papillary intralymphatic angioendothelioma (also known as Dabska tumor), retiform hemangioendo...
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: Luis Requena, Heinz Kutzner Source Type: research

Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management
This article presents an overview of the state of the art in the clinicopathological management of this disease.
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: Beatriz Llombart, Carlos Serra-Guillén, Carlos Monteagudo, José Antonio López Guerrero, Onofre Sanmartín Source Type: research

Atypical fibroxanthoma: a selective review
We present a review of this particular neoplasm with special emphasis on the histomorphology, subtypes, immunophenotypic profile, and discussion of differential diagnosis.
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: Alejandro A. Gru, Daniel J. Santa Cruz Source Type: research

Introduction
The human dermis and subcutis are constituted by a complex network of cells, fibers, fundamental substance, neural structures, vessels, and a rich deposit of fat. Most of these cells derive from the mesoderm, the most numerous being the fibroblasts that secret fibers and fundamental matrix proteins, elaborating abundant fibrillar structures, such as collagen and elastic fibers, the Schwann cells, which will form the neural structures, and the endothelial cells, which produce blood and lymphatic vessels. All these cells differentiate basically from dermal-derived multipotent stem cells (DMSC). In early embryonal stages, the...
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Authors: Antonio Llombart-Bosch, Carlos Monteagudo, Daniel J. Santa Cruz Source Type: research

Contents
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Source Type: research

Topics
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Source Type: research

Editorial Board
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Source Type: research

Masthead
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Source Type: research

Cover
Source: Seminars in Diagnostic Pathology - January 16, 2013 Category: Pathology Source Type: research

Role of Rho-Kinase Gene Polymorphisms and Protein Expressions in Colorectal Cancer Development
Pathobiology 2013;80:138–145 (DOI:10.1159/000341395)
Source: Pathobiology - January 16, 2013 Category: Pathology Source Type: research

The pathology of selenium deficiency in Cyprinus carpio L
Abstract Selenium is essential for the normal life processes, and all animals, including fish, need this inorganic element. In order to research the pathology of selenium deficiency in common carp, Cyprinus carpio L., 360 juvenile carp were allocated to three treatments. Each treatment containing 120 fish was randomly divided into four groups, fed with purified diets containing selenium at 0, 0.15, 0.30 and 0.45 mg kg−1. The results indicated that the morbidity and mortality rates of the test groups were negatively correlated with the level of selenium in the diets. The morbidity and mortality rates were, respectively,...
Source: Journal of Fish Diseases - January 16, 2013 Category: Zoology Authors: K Y Wang, C Z Peng, J L Huang, Y D Huang, M C Jin, Y Geng Tags: Original Article Source Type: research

Researchers at Stanford University and Intel Develop Silicon Microarray Chip Capable of Producing Clinical Pathology Laboratory Test Results in Minutes
Pathologists and clinical laboratory managers take note—this peptide chip microarray may have a role in point-of-care testing At the heart of a new point-of-care technology is a prototype silicon chip that contains up to 9,000 peptides and allows real-time analysis in just minutes. Researchers say this technology can significantly reduce the time-to-answer when compared to [...]
Source: Dark Daily - January 16, 2013 Category: Laboratory Medicine Authors: admin Tags: Instruments & Equipment Laboratory Hiring & Human Resources Laboratory Instruments & Laboratory Equipment Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Management & Operations Uncategorized Source Type: news

Am J Pathol; +25 new citations
25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Pathol These pubmed results were generated on 2013/01/16PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.
Source: Am J Pathol - January 16, 2013 Category: Pathology Tags: Report Source Type: research

Symptoms Of Duchenne Muscular Dystrophy Ameliorated By Tamoxifen
This study will be published in the February 2013 issue of The American Journal of Pathology...
Source: Health News from Medical News Today - January 16, 2013 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

New Clinical Targets Suggested For Duchenne Muscular Dystrophy
Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD. Their findings appear in the journal Stem Cells Translational Medicine. Duchenne muscular dystrophy is a genetic disorder caused by a mutation in the gene for dystrophin, a protein that anchors muscle cells in place when they contract. Without dystrophin, muscle contractions tear cell membranes, leading to cell death...
Source: Health News from Medical News Today - January 16, 2013 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells
A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells Nature 494, 7436 (2013). doi:10.1038/nature11813 Authors: Christoph S. N. Klose, Elina A. Kiss, Vera Schwierzeck, Karolina Ebert, Thomas Hoyler, Yannick d’Hargues, Nathalie Göppert, Andrew L. Croxford, Ari Waisman, Yakup Tanriver & Andreas Diefenbach At mucosal surfaces, the immune system should not initiate inflammatory immune responses to the plethora of antigens constantly present in the environment, but should remain poised to unleash a potent assault on intestinal pathogens. The tra...
Source: Nature - January 16, 2013 Category: Research Authors: Christoph S. N. KloseElina A. KissVera SchwierzeckKarolina EbertThomas HoylerYannick d’HarguesNathalie GöppertAndrew L. CroxfordAri WaismanYakup TanriverAndreas Diefenbach Tags: Letter Source Type: research

Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Abstract Alzheimer's disease is characterized by amyloid plaques, neurofibrillary tangles, glial activation, and neurodegeneration. In mouse models, inflammatory activation of microglia accelerates tau pathology. The chemokine fractalkine serves as an endogenous neuronal modulator to quell microglial activation. Experiments with fractalkine receptor null mice suggest that fractalkine signaling diminishes tau pathology, but exacerbates amyloid pathology. Consistent with this outcome, we report here that soluble fractalkine overexpression using adeno-associated viral vectors significantly reduced tau pathology in the...
Source: Neurobiology of Aging - January 16, 2013 Category: Geriatrics Authors: Nash KR, Lee DC, Hunt JB, Morganti JM, Selenica ML, Moran P, Reid P, Brownlow M, Guang-Yu Yang C, Savalia M, Gemma C, Bickford PC, Gordon MN, Morgan D Tags: Neurobiol Aging Source Type: research

5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5.
Abstract The 5-lipoxygenase (5LO) enzyme is widely distributed within the central nervous system. Previous works showed that this protein is upregulated in Alzheimer's disease, and that its genetic absence results in a reduction of amyloid beta levels in Tg2576 mice. However, its contribution to tau pathology remains to be investigated. To this end we studied the effect of 5LO chronic pharmacologic inhibition on endogenous tau level and metabolism in the same mice. The phosphorylation of tau at S396 and S396/404 in the brains of mice receiving zileuton, a selective and specific 5LO inhibitor, was significantly redu...
Source: Neurobiology of Aging - January 16, 2013 Category: Geriatrics Authors: Chu J, Praticò D Tags: Neurobiol Aging Source Type: research

Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support.
CONCLUSIONS: BMZ PAS-positivity of clinically uninvolved FPSUs of HS patients appears to be wispy or missing entirely. It is speculated that this may explain the apparent fragility of the sebofollicular junction. There is an increased concentration of inflammatory cells adjacent to these areas, whilst inflammatory cells are scarce in areas where the PAS material is intact. It is hypothesised that the PAS gap identifies areas susceptible to leakage, trauma and rupture, leading to release of materials that trigger inflammatory mediators, and the seeding of the dermis with free-living stem cells generating benign but invasive...
Source: The British Journal of Dermatology - January 16, 2013 Category: Dermatology Authors: William Danby F, Jemec GB, Marsch WC, von Laffert M Tags: Br J Dermatol Source Type: research

Validation of Whole Slide Imaging for Primary Diagnosis in Surgical Pathology.
Conclusions.-Based on our assumptions and study design, diagnostic review by WSI was not inferior to microscope slide review (P < .001). PMID: 23323732 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - January 16, 2013 Category: Laboratory Medicine Authors: Bauer TW, Schoenfield L, Slaw RJ, Yerian L, Sun Z, Henricks WH Tags: Arch Pathol Lab Med Source Type: research

A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.
Abstract p97/VCP is a hexameric AAA type ATPase that functions in a variety of cellular processes such as endoplasmic reticulum associated degradation (ERAD), organelle biogenesis, autophagy and cell-cycle regulation. Inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia (IBMPFD) is an autosomal dominant disorder which has been attributed to mutations in p97/VCP. Several missense mutations affecting twelve different amino acids have been identified in IBMPFD patients and some of them were suggested to be involved in the observed pathology. Here, we analyzed the effect of all ...
Source: The International Journal of Biochemistry and Cell Biology - January 16, 2013 Category: Biochemistry Authors: Erzurumlu Y, Kose FA, Gozen O, Gozuacik D, Toth EA, Ballar P Tags: Int J Biochem Cell Biol Source Type: research

Epidermal Panfolliculoma: An Adnexal Proliferation With Advanced Follicular Differentiation Confined To The Epidermis
We report an example of panfolliculoma purely confined to the epidermis. The lesion presented as a verrucous plaque on the leg of a 55‐year‐old man. Histopathologic sections demonstrated an acanthoma with follicular differentiation including areas mimicking the follicular germ, matrix, root sheath and infundibular components.
Source: Journal of Cutaneous Pathology - January 16, 2013 Category: Pathology Authors: Munir H. Idriss, Ahmed Khalil, Willaim Long, Dirk M Elston Tags: Case Report Source Type: research

Hypopigmented mycosis fungoides in Egyptian patients
Source: Journal of Cutaneous Pathology - January 16, 2013 Category: Pathology Authors: Hussein M. M Hassab‐El‐Naby, Mohamed A. El‐Khalawany Tags: Original Article Source Type: research

DKK2 in Ewing Sarcoma Pathology
In this study, we identified the pro-metastatic gene DKK2 as a highly overexpressed gene in Ewing sarcoma compared with corresponding normal tissues. Using RNA interference, we showed that DKK2 was critical for malignant cell outgrowth in vitro and in an orthotopic xenograft mouse model in vivo. Analysis of invasion potential in both settings revealed a strong correlation of DKK2 expression to Ewing sarcoma invasiveness that may be mediated by the DKK effector matrix metalloproteinase 1 (MMP1). Furthermore, gene expression analyses established the ability of DKK2 to differentially regulate genes such as CXCR4, PTHrP, RUNX2...
Source: Cancer Research - January 16, 2013 Category: Cancer & Oncology Authors: Hauer, K., Calzada-Wack, J., Steiger, K., Grunewald, T. G. P., Baumhoer, D., Plehm, S., Buch, T., da Costa, O. P., Esposito, I., Burdach, S., Richter, G. H. S. Tags: Tumor and Stem Cell Biology Source Type: research

Disentangling function from topology to infer the network properties of disease genes
Conclusions: Our approach is an important first step in extracting the residual topological differences in disease genes when accounting for function, and leads to new insights into the network properties of disease genes.
Source: BMC Systems Biology - Latest articles - January 16, 2013 Category: Molecular Biology Authors: Dario GhersiMona Singh Source Type: research

Pathology quality assurance review
The review will be led by national clinical director for pathology, Dr Ian Barnes, and will scrutinise NHS arrangements for the oversight and safeguards of laboratory testing. On 20 December 2012, NHS medical director, Professor Sir Bruce Keogh, wrote to the NHS, hospitals in the independent sector and independent treatment centres registered with the Care Quality Commission about the review.
Source: NHS Networks - January 16, 2013 Category: UK Health Authors: Maria Axford Source Type: news

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells
Nature advance online publication 16 January 2013. doi:10.1038/nature11813 Authors: Christoph S. N. Klose, Elina A. Kiss, Vera Schwierzeck, Karolina Ebert, Thomas Hoyler, Yannick d’Hargues, Nathalie Göppert, Andrew L. Croxford, Ari Waisman, Yakup Tanriver & Andreas Diefenbach At mucosal surfaces, the immune system should not initiate inflammatory immune responses to the plethora of antigens constantly present in the environment, but should remain poised to unleash a potent assault on intestinal pathogens. The transcriptional programs and regulatory factors required for immune cells to switch from homeostati...
Source: Nature AOP - January 16, 2013 Category: Research Authors: Christoph S. N. KloseElina A. KissVera SchwierzeckKarolina EbertThomas HoylerYannick d’HarguesNathalie GöppertAndrew L. CroxfordAri WaismanYakup TanriverAndreas Diefenbach Tags: Letter Source Type: research

Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support
ConclusionsBMZ PAS‐positivity of clinically uninvolved FPSUs of HS patients appears to be wispy or missing entirely. It is speculated that this may explain the apparent fragility of the sebofollicular junction. There is an increased concentration of inflammatory cells adjacent to these areas, whilst inflammatory cells are scarce in areas where the PAS material is intact.It is hypothesised that the PAS gap identifies areas susceptible to leakage, trauma and rupture, leading to release of materials that trigger inflammatory mediators, and the seeding of the dermis with free‐living stem cells generating benign but invasiv...
Source: British Journal of Dermatology - January 16, 2013 Category: Dermatology Authors: F. William Danby, G.B.E. Jemec, W.Ch. Marsch, M. Laffert Tags: Original Article Source Type: research

Dermatophile answers
ANSWERS From questions on page 16. ANSWER TO QUESTION 1 Answer is C, Linear immunoglobulin A (IgA) dermatosis is an autoimmune subepidermal vesiculobullous disease of children (chronic bullous dermatosis of childhood) and adults. It is the most common acquired blistering disease in the paediatric population and can appear as early as 6 months of age.1 Vesicles and bullae are usually arranged in an annular manner described as the ‘cluster of jewels’ appearance. Lesions in children occur mostly on the lower abdomen and anogenital areas with frequent oral and ocular involvement. Blood tests show antibodies di...
Source: Archives of Disease in Childhood - Education and Practice - January 16, 2013 Category: Pediatrics Authors: Chattopadhyay, M., Burrows, N. P. Tags: Surgery, Eye Diseases, Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, Infection (neurology), Ophthalmology, Pathology, Radiology, Sexual health, Dermatology, Surgical diagnostic tests, Clinical diagnostic tests, Poisoni Source Type: research

A new web-based method for automated analysis of muscle histology
Conclusions: A standardised and mainly automated quantitative assessment of histopathological parameters in the mdx mouse model is now available. Automated analysis of histological parameters is more rapid and less time-consuming. Moreover, results are unbiased and more reliable. Efficacy of therapeutic interventions, e.g. within the scope of a drug screening or therapeutic exon skipping, can be monitored. The automatic analysis system MyoScan used in this study is not limited exclusively to dystrophin-deficient mice but also represents a useful tool for applications in the research of other dystrophic pathologies, various...
Source: BMC Musculoskeletal Disorders - January 16, 2013 Category: Orthopaedics Authors: Cordula PertlMarkus EblenkampAnja PertlStefan PfeiferErich WintermantelHanns LochmüllerMaggie WalterSabine KrauseChristian Thirion Source Type: research

Quantitative methods for assessing tongue force
Por muitos anos, pesquisadores têm procurado métodos para quantificar a força da língua e muitos instrumentos foram construídos para este fim. O objetivo deste trabalho é apresentar uma revisão crítica da literatura sobre instrumentos para quantificar a força de língua. Os 30 aparelhos encontrados foram agrupados em quatro diferentes categorias: bocal contendo sensores (n=9), sensores fixados nos dentes, palato ou em placas palatais (n=8), bulbos preenchidos com fluidos e conectados a sensores de pressão (n=7) e outras tecnologias (n=8). Esses instrumentos podem, potencialmente, auxiliar o fonoaudiólogo na aval...
Source: Revista CEFAC - January 15, 2013 Category: Speech Therapy Source Type: research

Face changes on patients after aesthetic speech therapy treatment in School-Practice of Speech Therapy
CONCLUSION: speech treatment has proportioned facial changes which were noted by the patients, by others and by the specialists. The patients have shown more satisfaction with their faces' aesthetic aspects after the speech treatment.
Source: Revista CEFAC - January 15, 2013 Category: Speech Therapy Source Type: research

Academic and professional training of speech and language pathology teachers in the state of Bahia
CONCLUSIONS: it is perceivable that, although with a qualification that mostly did not include the area of public health, teachers realize this need and seek, within the areas of performance, to set forth alliances with preventive actions.
Source: Revista CEFAC - January 15, 2013 Category: Speech Therapy Source Type: research

Perception of SUS users: expectation and satisfaction of care in the Family Health Strategy
CONCLUSION: the Speech-Language and Hearing Pathology focuses its actions in secondary and high complexity levels, whereas such levels are cited as user's dissatisfaction. Therefore, we suggest the development of this research in such locations where Speech-Language and Hearing professionals are present.
Source: Revista CEFAC - January 15, 2013 Category: Speech Therapy Source Type: research

Towards the first words: therapy setting in intervention for babies with hearing loss
CONCLUSIONS: the case studied allowed for discussing aspects related to the therapeutic setting and characteristics of the intervention process when the subject is a baby. The discussion implies that the speech pathologist and audiologist should have background in child development and on mother-baby relationship in the first years of life.
Source: Revista CEFAC - January 15, 2013 Category: Speech Therapy Source Type: research

Transmission of tangles in Alzheimer's mice provides more authentic model of tau pathology
By using synthetic fibrils made from pure recombinant protein, researchers have provided the first direct and compelling evidence that tau fibrils alone are entirely sufficient to recruit and convert soluble tau within cells into pathological clumps in neurons, followed by transmission of tau pathology to other inter-connected brain regions from a single injection site in an animal model of tau brain disease.
Source: ScienceDaily Headlines - January 15, 2013 Category: Science Source Type: news

Cook Added to 2013 CAP Policy Meeting
Charlie Cook is confirmed as a guest speaker at the 2013 CAP Policy Meeting, held May 6–8 in Washington, DC.
Source: CAP Important Announcements and News - January 15, 2013 Category: Pathology Source Type: news

Discount for Molecular Medicine Tri-Conference
As a CAP member, take advantage of this last chance offer to save 20 percent on registration to the Molecular Medicine Tri-Conference held Feburary 11–15 in San Francisco.
Source: CAP Important Announcements and News - January 15, 2013 Category: Pathology Source Type: news

Reply to the Editor
I appreciate the thought-provoking arguments that our case report has generated. Stanger and Pepper present a balanced discussion of the controversial subject of surgical intervention in patients with acute type A aortic dissection (TAAD) with previous cardiac surgery. I agree that patients with previous cardiac surgery and spontaneous TAAD should be treated surgically in the absence of prohibitive comorbidities. These patients do have significantly higher operative mortality, however, as illustrated by a study published since the acceptance of our case report. Klodell and colleagues reported a disparity in hospital morali...
Source: The Journal of Thoracic and Cardiovascular Surgery - January 15, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Tomasz Timek Tags: Letters to the Editor Source Type: research

Unexpected brain lesions in lactating Sprague-Dawley rats in a Two-generation Inhalation Reproductive Toxicity Study with pentafluoropropane (HFC-245fa).
Abstract The study presented was conducted following the reproductive study guideline OECD Guideline 416 Two-Generation Reproduction Toxicity Study. Sprague-Dawley rats were exposed to 2000, 10,000 and 50,000ppm of HFC-245fa. There was an unexpected mortality of lactating dams in the medium and high dose group beginning at day 10 of lactation. Statistically significant histopathological alterations were observed in the cerebellum of a total of 9/30 females of the high dose group of the F(0)-generation and in 10/27 females of the high dose group of the F(1)-generation. In contrast there were no brain lesions found i...
Source: Experimental and Toxicologic Pathology - January 15, 2013 Category: Pathology Authors: Buschmann J, Fuhst R, Tillmann T, Ernst H, Kolling A, Pohlmann G, Preiss A, Berger-Preiss E, Hansen T, Kellner R, Rusch GM Tags: Exp Toxicol Pathol Source Type: research

Multiple system atrophy of the cerebellar type (MSA-C) with concomitant beta-amyloid and tau pathology.
Abstract Multiple system atrophy (MSA) is a rapidly progressive sporadic α-synucleinopathy with adult onset characterized by progressive cerebellar ataxia, basal ganglia symptoms, autonomic dysfunction and pyramidal tract signs. While full-blown dementia is considered an exclusion criterion according to Consensus Guidelines, mild cognitive deficits such as fronto-executive dysfunction have been reported in some MSA individuals. However, the underlying anatomic correlate still has to be elucidated. We here report a 74-year-old patient with a clinical diagnosis of "probable MSA of the cerebellar type (MSA-C)" who de...
Source: Clinical Neuropathology - January 15, 2013 Category: Pathology Authors: Bujan B, Hofer MJ, Oertel WH, Pagenstecher A, Bürk K Tags: Clin Neuropathol Source Type: research

Probable IgG4-related pachymeningitis: a case with transverse sinus obliteration.
Abstract IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory condition which often shows a dramatic response to steroid therapy. IgG4-RD can present either as a single lesion or as a systemic multi-organ disorder. Common histological findings include a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and phlebitis. Although diagnostic criteria for IgG4-RD have been proposed in many organs/sites, they are not well established in the central nervous system. Published data on IgG4-RD in meninges is also limited. To our knowledge, only 15 potential cases ...
Source: Clinical Neuropathology - January 15, 2013 Category: Pathology Authors: Tanboon J, Felicella MM, Bilbao J, Mainprize T, Perry A Tags: Clin Neuropathol Source Type: research

Epithelioid hemangioendothelioma of the meninges mimicking metastatic carcinoma: a case report.
Abstract Epithelioid hemangioendothelioma (EHE) is a rare, locally aggressive well-differentiated endothelial tumor, which frequently develops from the peripheral veins. Meningeal EHE has only been reportedin four previous cases. Here we report the case of a 38-year-old female with EHE of the meninges and secondary involvement of the skull. The patient presented with occasional headaches and slightly blurred vision. Computed tomography and magnetic resonance imaging showed a mass under the occipital bone and parietal bone, with involvement of the skull. Total resection of the tumor and involved occipital bone was p...
Source: Clinical Neuropathology - January 15, 2013 Category: Pathology Authors: Zheng J, Li P, Ma S, Geng M Tags: Clin Neuropathol Source Type: research