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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Connective Tissue Growth Factor (CCN2) in Blood Vessels.
Abstract The CCN family comprise the products of six immediate-early response genes (Cyr61, Ctgf, Nov and Wisp1-3) and are multi-functional proteins, characterised by four discrete protein modules in which reside functional domains: an insulin-like growth factor binding protein-like module (IGFBP) but has low affinity for IGFBPs, a von Willebrand factor type C repeat module (VWC) which mediates integrin and growth factor binding, a thrombospondin type-1 repeat module (TSP-1), and a cysteine-knot-containing module (CT). These modules mediate a host of interactions such as growth factor binding, integrin recognition,...
Source: Vascular Pharmacology - February 1, 2013 Category: Drugs & Pharmacology Authors: Ponticos M Tags: Vascul Pharmacol Source Type: research

Ovarian metastasis from adenocarcinoma of the lung
A case of a young woman, affected by an unresectable pulmonary adenocarcinoma, diagnosed by broncoscopy with biopsies and treated with platinum‐pemetrexed based chemotherapy, with an incidental finding of a left ovarian mass. At ultrasound examination, a solid lesion was detected in the left ovary. Final pathology revealed an ovarian metastasis from low differentiate adenocarcinoma of the lung. This experience gives us an example of an ovarian metastasis from lung cancer, which at ultrasound examination appears as solid ovarian mass, with lobulated margins, moderate vascularisation, adjacent to normal ovarian parenchyma....
Source: Ultrasound in Obstetrics and Gynecology - February 1, 2013 Category: Radiology Authors: Antonia C Testa, Ilaria De Blasis, Alessia Di Legge, Giovanni Scambia Tags: Letter to the Editor Source Type: research

Essential role of Stem Cell Factor/c‐Kit Signaling Pathway in Bleomycin‐Induced Pulmonary Fibrosis
In this study the potential role of the SCF/c‐Kit axis in pulmonary fibrosis was examined. Fibrosis was induced by intratracheal instillation of bleomycin (BLM), which caused increased SCF levels in plasma, bronchoalveolar lavage fluid (BALF) and lung tissue, as well as increased expression by lung fibroblasts. These changes were accompanied by increased numbers of bone marrow‐derived c‐Kit+ cells in the lung with corresponding depletion in bone marrow. Both recombinant SCF and lung extracts from BLM‐treated animals induced bone‐marrow cell migration, which was blocked by c‐Kit inhibitor. The migrated cells pro...
Source: The Journal of Pathology - February 1, 2013 Category: Pathology Authors: Lin Ding, Vladilsav Dolgachev, Zhuang Wu, Tianju Liu, Taku Nakashima, Zhe Wu, Matthew Ullenbruch, Nicholas W Lukacs, Zidi Chen, Sem H Phan Tags: Original Article Source Type: research

Incidental detection of an isolated microfilaria in squash cytology of an oligodendroglioma: the unexpected ‘worm’ in the pie
Source: Cytopathology - February 1, 2013 Category: Pathology Authors: M. Singh, K. Majumdar, M. Shramana, S. Ravindra, S. Daljit Tags: Correspondence Source Type: research

Role of Napsin A and TTF1 as a Diagnostic Marker for Lung Adenocarcinoma.
PMID: 23368855 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Iqbal J Tags: Arch Pathol Lab Med Source Type: research

Validation of KRAS Testing for Anti-EGFR Therapeutic Decisions for Patients With Metastatic Colorectal Carcinoma.
PMID: 23368856 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Idowu MO Tags: Arch Pathol Lab Med Source Type: research

College of american pathologists gynecologic cytopathology quality consensus conference on good laboratory practices in gynecologic cytology: background, rationale, and organization.
Conclusions.-This paper describes the rationale, background, process, and strengths and limitations of a series of papers that summarize good laboratory practice statements in quality assurance in gynecologic cytopathology. PMID: 23368857 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Tworek JA, Henry MR, Blond B, Jones BA Tags: Arch Pathol Lab Med Source Type: research

The Role of Monitoring Interpretive Rates, Concordance Between Cytotechnologist and Pathologist Interpretations Before Sign-Out, and Turnaround Time in Gynecologic Cytology Quality Assurance: Findings From the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 1.
Conclusions.-The outcomes of this process demonstrate the current state of practice patterns in gynecologic cytology QA. Monitoring interpretive rates for all Bethesda System categories is potentially useful, and it is most useful to monitor interpretive rates for cytotechnologists individually and in comparison to the entire laboratory. Laboratories need to determine what level of discrepancy between cytotechnologist and pathologist interpretations of Pap tests is important to track. Laboratories should consider formalizing procedures and policies to adjudicate such discrepant interpretations. Turnaround time should be mo...
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Clary KM, Davey DD, Naryshkin S, Austin RM, Thomas N, Chmara BA, Sugrue C, Tworek J Tags: Arch Pathol Lab Med Source Type: research

Prospective and Retrospective Review of Gynecologic Cytopathology: Findings From the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 2.
Conclusions.-The number of Pap tests from high-risk patients should be maximized in prospective and retrospective rescreening. Unsatisfactory Pap tests should also be included. All readily identifiable high-risk human papillomavirus-positive cases with an interpretation of negative for intraepithelial lesion or malignancy should be prospectively rescreened. Cervical biopsy results with high-grade cervical intraepithelial neoplasia or worse (CIN 2+) should trigger retrospective rescreening. Regular feedback should be provided to cytotechnologists and cytopathologists. Upgraded diagnoses from negative for intraepithelial les...
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Brainard JA, Birdsong GG, Elsheikh TM, Hartley DA, Naik K, Neal MH, Souers RJ, Henry MR Tags: Arch Pathol Lab Med Source Type: research

The Role of Proficiency Testing in Ensuring Quality: Findings From the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 3.
Conclusions.-Two-thirds of laboratories report having an individual with an unsuccessful proficiency testing score. More than 90% did not initiate any remedial action for 1 or 2 unsuccessful tests; 84% of laboratories reported they actively monitored results from proficiency testing, but most laboratories did not initiate any remedial action for cytotechnologists (81.4%; 376 of 462) or pathologists (87.7%; 405 of 462) who passed a proficiency test but who did not score 100%. Proficiency testing pass-fail rates should be monitored globally for the laboratory and for each individual. Proficiency testing slides should be pres...
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Howell LP, Nayar R, Savaloja L, Tabbara S, Thomas N, Winkler B, Tworek J Tags: Arch Pathol Lab Med Source Type: research

General Quality Practices in Gynecologic Cytopathology: Findings From the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 3.
Conclusions.-Laboratories follow many metrics. Most laboratories facilitate comparison of individual metrics against the laboratory's metrics: 81.1% for cytotechnologists and 59.6% for pathologists. The majority of laboratories facilitate comparison of individual cytotechnologist metrics with other cytotechnologists, but less frequently metrics from pathologists with other individuals. The most common methods to recognize variance in performance in individuals were by identifying outliers from the data or by user-defined action limits. The most common method to address variance was an attempt to identify the cause of the v...
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Tworek J, Nayar R, Savaloja L, Tabbara S, Thomas N, Winkler B, Howell LP Tags: Arch Pathol Lab Med Source Type: research

Quality Improvement Opportunities in Gynecologic Cytologic-Histologic Correlations: Findings From the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 4.
Conclusions.-Cytologic-histologic correlations can be performed retrospectively, during initial case review, or both. At minimum, all available slides should be reviewed for a high-grade squamous intraepithelial lesion Papanicolaou test with negative biopsies. The preferred monitor for correlations is the positive predictive value of a Papanicolaou test. Laboratories should design cytologic-histologic correlation programs to explore existing or perceived quality deficiencies. PMID: 23368862 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Crothers BA, Jones BA, Cahill LA, Moriarty AT, Mody DR, Tench WD, Souers RJ Tags: Arch Pathol Lab Med Source Type: research

Monitoring and Ordering Practices for Human Papillomavirus in Cervical Cytology: Findings From the College of American Pathologists Gynecologic Cytopathology Quality Consensus Conference Working Group 5.
Conclusions.-It is not appropriate for laboratories to offer low-risk human papillomavirus testing for any clinical circumstance in gynecologic cytology. Laboratories should not order human papillomavirus testing to resolve diagnostic discrepancies. It is a valuable broad measure of laboratory quality to monitor the human papillomavirus-positive rates in Papanicolaou tests with atypical squamous cells. PMID: 23368863 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Booth CN, Bashleben C, Filomena CA, Means MM, Wasserman PG, Souers RJ, Henry MR Tags: Arch Pathol Lab Med Source Type: research

Utilization of stat test priority in the clinical laboratory: a college of american pathologists q-probes study of 52 institutions.
Conclusions.-Among the 52 participating laboratories, the median stat testing rate was 37.0% and a median 73.3% of the test menu was offered stat. PMID: 23368864 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Volmar KE, Wilkinson DS, Wagar EA, Lehman CM Tags: Arch Pathol Lab Med Source Type: research

Accounting for the professional work of pathologists performing autopsies.
Conclusion.-Although we recognize that autopsy practices vary significantly from institution to institution, it is hoped that our proposed guidelines will be a valuable starting point that individual practices can then adapt, taking into account the specifics of their practice environment. PMID: 23368865 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Sinard JH Tags: Arch Pathol Lab Med Source Type: research

Connective tissue growth factor immunohistochemical expression is associated with gallbladder cancer progression.
Conclusions.- Our results suggest a role for CTGF in GBC progression and a positive association with better prognosis. In addition, they underscore the importance of considering the involvement of inflammation on GBC development. PMID: 23368866 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Garcia P, Leal P, Alvarez H, Brebi P, Ili C, Tapia O, Roa JC Tags: Arch Pathol Lab Med Source Type: research

Low-grade clear cell renal cell carcinoma mimicking hemangioma of the kidney: a series of 4 cases.
Conclusion.- Extensive sampling and immunohistochemical workup of what is deemed to be a benign vascular neoplasm of the kidney is needed to rule out the presence of individual carcinoma cells or small viable carcinoma cell clusters. PMID: 23368867 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Kryvenko ON, Roquero L, Gupta NS, Lee MW, Epstein JI Tags: Arch Pathol Lab Med Source Type: research

Wolf isotopic response manifesting as postherpetic granuloma annulare: a case series.
Conclusions.- All cases of postherpetic Wolf isotopic response reported in this series revealed granuloma annulare, with a perineurovascular or perifollicular pattern of lymphohistiocytic infiltration including multinucleated giant cells, and occurred following herpes zoster or herpes simplex infection, although herpes viral infection was not always associated with a subsequent isotopic eruption. Awareness of this entity can aid in the clinicopathologic diagnosis of granuloma annulare occurring at the site of prior herpes viral infection. PMID: 23368868 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Kapoor R, Piris A, Saavedra AP, Duncan LM, Nazarian RM Tags: Arch Pathol Lab Med Source Type: research

Diagnostic complexities of eosinophilia.
Conclusions.- Eosinophilia is a common, hematologic abnormality with diverse etiologies. The underlying causes can be broadly divided into reactive, clonal, and idiopathic. Classically, many cases of eosinophilia were grouped together into the umbrella category of hypereosinophilic syndrome, a clinical diagnosis of exclusion. In recent years, an improved mechanistic understanding of many eosinophilias has revolutionized the way these disorders are understood, diagnosed, and treated. As a result, specific diagnoses can now be assigned in many cases that were previously defined as hypereosinophilic syndrome. Most notably, ch...
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Montgomery ND, Dunphy CH, Mooberry M, Laramore A, Foster MC, Park SI, Fedoriw YD Tags: Arch Pathol Lab Med Source Type: research

Approach to intraoperative consultation for donor liver biopsies.
Conclusions.- Malignancy and extensive necrosis in the liver are absolute contraindications to transplantation. Evaluation of macrosteatosis, fibrosis, hepatitis, and necrosis depends on the severity of disease and correlation with the clinical situation. Donor age of greater than 60 years does not preclude transplantation. Artifacts and benign conditions need to be understood to prevent wastage of precious organs and to ensure that an appropriate organ is provided for the recipient. PMID: 23368870 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Melin C, Miick R, Young NA, Ortiz J, Balasubramanian M Tags: Arch Pathol Lab Med Source Type: research

Ovarian serous carcinoma associated with a distinct "corded and hyalinized" pattern.
We describe a unique case of serous neoplasm of low malignant potential with low-grade serous carcinoma combined with a distinct pattern of high-grade carcinoma characterized by cords of epithelioid and spindled cells enmeshed in a hyalinized, collagenous stroma. This pattern was the predominant architecture in the patient's recurrence and caused a diagnostic challenge, as the splenic recurrence was initially diagnosed as a second primary high-grade spindle cell neoplasm. Both ovarian and splenic tumors displayed positive immunohistochemical staining for cytokeratin 7, cytokeratin 8/18, estrogen receptor, and paired box ge...
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Estrella JS, Wolf JK, Deavers MT Tags: Arch Pathol Lab Med Source Type: research

Anaplastic large cell lymphoma: a potential pitfall in the differential diagnosis of melanoma.
We report a 69-year-old man with a history of acral melanoma, metastatic to inguinal nodes, presenting with an ipsilateral thigh nodule. Histology showed a proliferation of pleomorphic cells in the dermis and subcutis, suspicious for melanoma. S100, Melan-A, and HMB-45 immunohistochemistry were negative. However, microphthalmia-associated transcription factor and CD117 labeled the neoplasm, prompting consideration of a late metastatic melanoma with loss of antigen expression. Subsequent immunolabeling for CD4, CD43, and CD30 and clonal T-cell gene rearrangements enabled the correct diagnosis of cutaneous anaplastic large c...
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Pulitzer M, Brady MS, Blochin E, Amin B, Teruya-Feldstein J Tags: Arch Pathol Lab Med Source Type: research

Microcystic/Reticular schwannoma of the proximal sigmoid colon: case report with review of literature.
We report a case of microcystic/reticular schwannoma of the proximal sigmoid colon in a 61-year-old man. A 12-mm polyp was detected while the patient was undergoing screening for colorectal neoplasm. This rare variant of schwannoma was initially described in 2008 and shows a predilection for the visceral organs, predominantly the gastrointestinal tract. We also review 11 other reported cases of microcystic/reticular schwannomas in the gastrointestinal tract. Unlike conventional gastrointestinal schwannomas, which are more common in the stomach, this variant appears to be more common in the large intestine. Histologic exami...
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Trivedi A, Ligato S Tags: Arch Pathol Lab Med Source Type: research

Kaposi sarcoma.
Abstract Kaposi sarcoma (KS) is a low-grade vascular tumor associated with Kaposi sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8) infection. Kaposi sarcoma lesions predominantly present at mucocutaneous sites, but may involve all organs and anatomic locations. Recognized epidemiologic-clinical forms of KS include classic, African (endemic), AIDS-associated (epidemic), and iatrogenic KS. New clinical manifestations have been described, such as antiretroviral therapy-related KS regression or flares. Kaposi sarcoma lesions evolve from early (patch stage) macules into plaques (plaque stage) that grow into larger no...
Source: Archives of Pathology and Laboratory Medicine - February 1, 2013 Category: Laboratory Medicine Authors: Radu O, Pantanowitz L Tags: Arch Pathol Lab Med Source Type: research

Loss of Cftr function exacerbates the phenotype of Na+ hyperabsorption in murine airways.
Abstract Airway surface hydration depends on the balance between transepithelial Na(+) absorption and Cl(-) secretion. In adult mice, absence of functional cystic fibrosis transmembrane conductance regulator (Cftr) fails to recapitulate human cystic fibrosis (CF) lung disease. In contrast, overexpression of the epithelial Na(+) channel β subunit in transgenic mice (βENaC-Tg) produces unregulated Na(+) hyperabsorption and results in CF(-)like airway surface dehydration, mucus obstruction, inflammation, and increased neonatal mortality. To investigate whether the combination of airway Na(+) hyperabsorption and abse...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - February 1, 2013 Category: Cytology Authors: Livraghi-Butrico A, Kelly EJ, Wilkinson KJ, Rogers TD, Gilmore RC, Harkema JR, Randell SH, Boucher RC, O'Neal WK, Grubb BR Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Improved survival in the largest national cohort of adults with cerebellar versus supratentorial low-grade astrocytomas.
Conclusions Taken together, adults with cerebellar WHO Grade I and II astrocytomas have a much more favorable survival curve than those with similar supratentorial tumors. Research demonstrates that the primary driver of this phenomenon is the improved survival in patients with cerebellar Grade II gliomas. PMID: 23373452 [PubMed - in process]
Source: Neurosurgical Focus - February 1, 2013 Category: Neurosurgery Authors: Bagley JH, Babu R, Friedman AH, Adamson C Tags: Neurosurg Focus Source Type: research

Extensive endovascular repair of thoracic aorta: observational analysis of the results and effects on spinal cord perfusion.
Conclusions: The coverage of the entire thoracic aorta is an effective procedure with high probability of success. Spinal cord malperfusion remains a serious complication especially in patients with prior aortic surgery but if collateral blood supply is maintained the occlusion of intercostal arteries do not determine paraplegia or paraparesis. In order to consider acute or chronic occlusion of subclavian, lumbar or hypogastric arteries so preventing spinal cord ischemia, strong preoperative evaluation including analysis of previous surgery for abdominal aortic aneurysm repair and avoidance of T12 aortic segment coverage i...
Source: The Journal of Cardiovascular Surgery - February 1, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Mastroroberto P, Ciranni S, Indolfi C Tags: J Cardiovasc Surg (Torino) Source Type: research

Neurological sequelae from brachiocephalic vein stenosis.
Abstract Stenosis of central veins (brachiocephalic vein [BCV] and superior vena cava) occurs in 30% of hemodialysis patients, rarely producing intracranial pathology. The authors present the first cases of BCV stenosis causing perimesencephalic subarachnoid hemorrhage and myoclonic epilepsy. In the first case, a 73-year-old man on hemodialysis presented with headache and blurry vision, and was admitted with presumed idiopathic intracranial hypertension after negative CT studies and confirmatory lumbar puncture. The patient mildly improved until hospital Day 3, when he experienced a seizure; emergency CT scans sho...
Source: Journal of Neurosurgery - February 1, 2013 Category: Neurosurgery Authors: Herzig DW, Stemer AB, Bell RS, Liu AH, Armonda RA, Bank WO Tags: J Neurosurg Source Type: research

Ghrelins, Obestatin, Nesfatin-1 and Leptin Levels in Pregnant Women With and Without Hyperemesis Gravidarum.
CONCLUSION: This pilot study suggests a possible role of leptin and nesfatin-1, which might be involved in the pathology of the disease. PMID: 23380589 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - February 1, 2013 Category: Biochemistry Authors: Gungor S, Gurates B, Aydin S, Sahin I, Kavak SB, Kumru S, Celik H, Aksoy A, Yilmaz M, Catak Z, Citil C, Baykus Y, Deniz R, Karakaya F, Ozdemir N Tags: Clin Biochem Source Type: research

To what extent does nonanalytic reasoning contribute to visual learning in cytopathology?
CONCLUSIONSNonanalytic reasoning in cytopathology image interpretation can be as accurate as traditional feature‐based reasoning. Encouraging trainees to adopt pattern recognition strategies may help to expedite the acquisition of visual interpretation skills in cytopathology training programs, yet combining analytic and nonanalytic reasoning do not appear to be effective. Cancer (Cancer Cytopathol) 2013. © 2013 American Cancer Society.
Source: Cancer Cytopathology - February 1, 2013 Category: Pathology Authors: Andrew Evered, Darren Walker, Andrew A. Watt, Nick Perham Tags: Original Article Source Type: research

Pathology Reporting of Neuroendocrine Tumors: Essential Elements for Accurate Diagnosis, Classification, and Staging
Much recent debate has focused on the optimal classification of epithelial neuroendocrine tumors (NETs). Multiple different systems of terminology, grading, and staging have been proposed, and some systems combine elements of grade and stage into a single prognostic classification. Recently, national and international consensus groups have attempted to standardize the classification of NETs, especially for those arising in the gastrointestinal tract and pancreas. Furthermore, the recognition that common classification criteria (such as proliferative rate) span multiple different systems allows the basic data necessary to p...
Source: Seminars in Oncology - February 1, 2013 Category: Cancer & Oncology Authors: David S. Klimstra Tags: Emily K. Bergsland, MD, Guest Editor Source Type: research

Prognostication of outcome with feline cutaneous mast cell tumors
Mast cell tumors (MCTs) comprise up to 21% of all feline cutaneous neoplasms. The tumors are typically located on the head and neck, followed by the trunk and limbs. Histologically, they are categorized as either mastocytic or the less common atypical MCT. The mastocytic type can be either well-differentiated or pleomorphic.
Source: Advances in Small Animal Medicine and Surgery - February 1, 2013 Category: Veterinary Research Tags: Clinical Pathology Source Type: research

Transformation zone sampling rate used as a performance indicator for cervical liquid‐based cytology sample‐takers
ConclusionsIdentification of practitioners with low TZSRs compared with their peers allows these individuals to be selected for personalized observation and training by a specialist in cervical cytology which can lead to an improvement in TZSR. As previous studies show a significant correlation between the TZSR and the detection rate of cytological abnormality it is useful to investigate low TZSRs.
Source: Cytopathology - February 1, 2013 Category: Pathology Authors: C. A. Faraker, J. Greenfield Tags: Original Article Source Type: research

Rash
This article explores the assessment of the patient with a dermatology condition, outlines the appropriate dermatological terminology to describe rashes and discusses common presentations of the acute, chronic and infective rashes with their appropriate treatments.
Source: Medicine - February 1, 2013 Category: Internal Medicine Authors: Shalini Narayan Tags: Common medical presentations Source Type: research

Pathological response to neoadjuvant chemotherapy for muscle‐invasive micropapillary bladder cancer
Conclusions Almost half of the patients responded completely to neoadjuvant chemotherapy with a pT0 rate of 45%; therefore, patients with the micropapillary variant of urothelial carcinoma should not be excluded from consideration for neoadjuvant chemotherapy.
Source: BJU International - February 1, 2013 Category: Urology & Nephrology Authors: Joshua J. Meeks, Jennifer M. Taylor, Kazuhito Matsushita, Harry W. Herr, S. Machele Donat, Bernard H. Bochner, Guido Dalbagni Tags: Urological Oncology Source Type: research

Metanephric adenoma and solid variant of papillary renal cell carcinoma: common and distinctive features
ConclusionsDespite overlapping features, careful morphological and architectural evaluation should result in accurate diagnosis of most MA and s‐PRCC. In challenging cases IHC stains for WT1, EMA and AMACR may help distinguishing these two entities.© 2013 Blackwell Publishing Ltd
Source: Histopathology - February 1, 2013 Category: Pathology Authors: Mariana M. Padilha, Athanase Billis, Daniela Allende, Ming Zhou, Cristina Magi‐Galluzzi Tags: Original Article Source Type: research

[Galen of Pergamum (129-216/217 AD) and his contribution to urology : Part I: life, work and medical system.]
[Galen of Pergamum (129-216/217 AD) and his contribution to urology : Part I: life, work and medical system.] Urologe A. 2013 Feb 1; Authors: Marx FJ Abstract Galen of Pergamum was, along with Hippocrates, the most influential physician and undoubtedly the most important medical scholar of classical antiquity. His anatomy and his concept of humoral pathology dominated western medicine until the sixteenth century and influenced all fields of medicine until after the seventeenth century. After referring to some biographical data the philosophical and epistemic fundamentals of Galen's"medical system" are outli...
Source: Der Urologe. Ausg. A - February 1, 2013 Category: Urology & Nephrology Authors: Marx FJ Tags: Urologe A Source Type: research

Transforaminal epidural steroid injections prevent the need for surgery in patients with sciatica secondary to lumbar disc herniation: a retrospective case series.
Conclusion: Transforaminal epidural steroid injections are an important treatment tool, preventing the need for surgery in 56% of patients with LDH. PMID: 23351495 [PubMed - as supplied by publisher]
Source: Canadian Journal of Surgery - February 1, 2013 Category: Surgery Authors: Manson NA, McKeon MD, Abraham EP Tags: Can J Surg Source Type: research

Quality indicators for sentinel lymph node biopsy: Is there room for improvement?
Conclusion: Applying QIs for SLNB was feasible, but modifications were necessary to develop a more practical approach to quality assessment. Of the 11 suggested QIs, those that encompass protocols (nuclear medicine and pathology) should be reclassified as prerequisites, as they are independent of the technical aspect of SLNB performance. The remaining 8 QIs encompass surgery per se and should be measured routinely by surgeons. Furthermore, concise and clinically relevant target rates are necessary for these QIs to be established as widely recognized control standards. PMID: 23351501 [PubMed - as supplied by publisher]
Source: Canadian Journal of Surgery - February 1, 2013 Category: Surgery Authors: Acuna SA, Angarita FA, McCready DR, Escallon J Tags: Can J Surg Source Type: research

[Fetal MRI and ultrasound of congenital CNS anomalies.]
Abstract In the last decade the newest technologies, fetal magnetic resonance imaging (MRI) and 3D ultrasound, have given an insight into the minute structures of the fetal brain. However, without knowledge of the basic developmental processes the imaging is futile. Knowledge of fetal neuroanatomy corresponding to the gestational week is necessary in order to recognize pathological structures. Furthermore, a modern neuroradiologist should be acquainted with the three steps in the formation of the cerebral cortex: proliferation, migration and differentiation of neurons in order to be in a position to suspect that th...
Source: Der Radiologe - February 1, 2013 Category: Radiology Authors: Pogledic I, Meyberg-Solomayer G, Reith W Tags: Radiologe Source Type: research

Bright-Field Microscopy for HER2 Gene Assessment: Not Just DISH-ful Thinking?
PMID: 23355196 [PubMed - in process]
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Clark BZ, Bhargava R Tags: Am J Clin Pathol Source Type: research

Thyrotropin receptor antibody assays: clinical utility.
PMID: 23355197 [PubMed - in process]
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Winter WE, Jialal I, Devaraj S Tags: Am J Clin Pathol Source Type: research

Comparison of Fluorescence In Situ Hybridization (FISH) and Dual-ISH (DISH) in the Determination of HER2 Status in Breast Cancer.
Abstract The determination of HER2 amplification is critical to selecting appropriate patients for HER2 targeted therapy in breast cancer. Dual in situ hybridization (DISH), an alternative to fluorescence in situ hybridization (FISH) and immunohistochemistry, is now available. To compare the FISH and DISH methods, we tested 251 samples enriched for common or difficult-to-assess HER2 anomalies. Seven samples failed DISH testing. There was a 64% (156/244) concordance between FISH and DISH by anomaly (κ = 0.58, 95% confidence interval, 0.51-0.65; P < .0001) and an 83% (203/244) concordance by amplification status ...
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Mansfield AS, Sukov WR, Eckel-Passow JE, Sakai Y, Walsh FJ, Lonzo M, Wiktor AE, Dogan A, Jenkins RB Tags: Am J Clin Pathol Source Type: research

A broad survey of cathepsin k immunoreactivity in human neoplasms.
Abstract Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relati...
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Zheng G, Martignoni G, Antonescu C, Montgomery E, Eberhart C, Netto G, Taube J, Westra W, Epstein JI, Lotan T, Maitra A, Gabrielson E, Torbenson M, Iacobuzio-Donahue C, Demarzo A, Shih IeM, Illei P, Wu TC, Argani P Tags: Am J Clin Pathol Source Type: research

Napsin a expression in primary mucin-producing adenocarcinomas of the lung: an immunohistochemical study.
Abstract Immunohistochemical expression of napsin A in primary pulmonary mucinous tumors is not well established. Napsin A immunoreactivity was evaluated in 43 mucin-producing adenocarcinomas of the lung consisting of 18 tumors formerly classified as mucinous bronchioloalveolar carcinoma, 15 colloid adenocarcinomas, 5 solid predominant adenocarcinomas with mucin production, and 5 adenocarcinomas with signet ring cell features, as well as in 25 extrapulmonary mucinous adenocarcinomas of different anatomic sites. Immunohistochemical expression of thyroid transcription factor 1 (TTF-1) was also compared. Thirty-three ...
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Wu J, Chu PG, Jiang Z, Lau SK Tags: Am J Clin Pathol Source Type: research

Combined Loss of E-cadherin and Aberrant β-Catenin Protein Expression Correlates With a Poor Prognosis for Small Intestinal Adenocarcinomas.
In conclusion, loss of E-cadherin and aberrant β-catenin expression correlate with poorly differentiated tumors, advanced T classification, and decreased patient survival time; therefore, it could be a prognostic factor in patients with SIAC. PMID: 23355201 [PubMed - in process]
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Lee HJ, Lee OJ, Jang KT, Bae YK, Chung JY, Eom DW, Kim JM, Yu E, Hong SM Tags: Am J Clin Pathol Source Type: research

Morphologic and immunocytochemical performances of effusion cell blocks prepared using 3 different methods.
Abstract With increased use of the ThinPrep method for nongynecologic specimens, cell blocks are more commonly prepared by harvesting cells that are fixed in CytoLyt solution. The current study compared morphologic and immunocytochemical performance of effusion cell blocks prepared using CytoLyt-prefixed thrombin clot (CTC) with plasma thrombin clot (PT) and HistoGel (HG) preparation. The study included a total of 25 malignant or benign serous fluids. Three individual cell block materials were simultaneously prepared from each of the 25 effusion specimens using the CTC, PT, or HG method. H&E staining and immuno...
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Jing X, Li QK, Bedrossian U, Michael CW Tags: Am J Clin Pathol Source Type: research

Facilitating the Laboratory Diagnosis of α1-Antitrypsin Deficiency.
In conclusion, a reference compendium of known AAT phenotypes was established that can serve as a resource for interpreting AAT phenotypes. PMID: 23355203 [PubMed - in process]
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Greene DN, Elliott-Jelf MC, Straseski JA, Grenache DG Tags: Am J Clin Pathol Source Type: research

Analytical performance and clinical utility of a bioassay for thyroid-stimulating immunoglobulins.
Abstract The analytical performance and the clinical utility of a thyrotropin receptor (TSHR)-stimulating immunoglobulin (TSI) bioassay were compared with those of a TSHR-binding inhibitory immunoglobulin (TBII) assay. Limits of detection (LoD) and quantitation (LoQ), assay cutoff, and the half-maximal effective concentration (EC(50)) were measured. Dilution analysis was performed in sera of hyperthyroid patients with Graves disease (GD) during antithyroid treatment (ATD). Titer was defined as the first dilution step at which measurement of TSI or TBII fell below the assay cutoff. The LoD, LoQ, cutoff, and EC(50) o...
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Leschik JJ, Diana T, Olivo PD, König J, Krahn U, Li Y, Kanitz M, Kahaly GJ Tags: Am J Clin Pathol Source Type: research

Establishment of a CYP2C19 Genotyping Assay for Clinical Use.
Abstract Conversion of clopidogrel (Plavix) to its active metabolite is catalyzed largely by the P450 enzyme 2C19 (CYP2C19). Numerous allelic variants of CYP2C19 exist. The *1 allele is considered wild type, whereas the *2 and *3 alleles have no in vivo enzymatic activity. Conversely, the *17 allele has increased expression, resulting in increased clopidogrel activation. Poor metabolizers (*2/*2 and *2/*3 genotypes) experience higher rates of therapeutic failure. For this reason, we have validated a CYP2C19 genotyping assay for the *1, *2, *3, and *17 alleles. Genomic DNA extracted from 30 deidentified EDTA whole-b...
Source: American Journal of Clinical Pathology - February 1, 2013 Category: Pathology Authors: Cervinski MA, Schwab MC, Lefferts JA, Lewis LD, Lebel KA, Tyropolis AM, Pflueger SM, Tsongalis GJ Tags: Am J Clin Pathol Source Type: research