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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 17.

Protein restriction cycles reduce IGF‐1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model
Summary In laboratory animals Calorie Restriction (CR) protects against aging, oxidative stress and neurodegenerative pathologies. Reduced levels of growth hormone and IGF‐1, which mediate some of the protective effects of CR, can also extend longevity and protect against age‐related diseases in rodents and humans. However, severely restricted diets are difficult to maintain and are associated with chronically low weight and other major side effects. Here, we show that four months of periodic protein restriction cycles (PRC) with supplementation of non‐essential amino acids in mice already displaying significant cogn...
Source: Aging Cell - January 31, 2013 Category: Cytology Authors: Edoardo Parrella, Tom Maxim, Francesca Maialetti, Lu Zhang, Junxiang Wan, Min Wei, Pinchas Cohen, Luigi Fontana, Valter D. Longo Tags: Original Paper Source Type: research

Peritoneal adhesion index (PAI): proposal of a score for the ¿ignored iceberg¿ of medicine and surgery
Peritoneal adhesions describe a condition in which pathological bonds form between the omentum, the small and large bowels, the abdominal wall, and other intra-abdominal organs. Different classification systems have been proposed, but they do not resolve the underlying problem of ambiguity in the quantification and definition of adhesions. We therefore propose a standardized classification system of adhesions to universalize their definition based on the macroscopic appearance of adhesions and their diffusion to different regions of the abdomen. By scoring with these criteria, the peritoneal adhesion index (PAI) can range ...
Source: World Journal of Emergency Surgery - January 31, 2013 Category: Emergency Medicine Authors: Federico CoccoliniLuca AnsaloniRoberto ManfrediLuca CampanatiElia PoiasinaPaolo BertoliMichela Giulii CapponiMassimo SartelliSalomone Di SaverioMichele CucchiDaniel LazzareschiMichele PisanoFausto Catena Source Type: research

Wide-field Imaging of the Retina
Abstract: The retinal periphery is the site of pathology in several eye diseases. Imaging of the peripheral retina offers a way to diagnose, monitor, and evaluate responses to the treatment of these conditions. Traditional fundus cameras have offered a 30- to 50-degree field of view. Recent technology has advanced to provide up to a 200-degree field of view. The utility of this technology in clinical practice continues to be investigated; wide-field color photography, autofluorescence imaging, and fluorescein angiography have been used for imaging peripheral retinal disease. Due to the limitations of this imaging technolog...
Source: Survey of Ophthalmology - January 31, 2013 Category: Opthalmology Authors: Matthew T. Witmer, Szilárd Kiss Tags: Major Review Source Type: research

Human Dissection and the Science and Art of Leonardo da Vinci
Anatomy and pathology are 2 of medicine’s oldest and most distinguished disciplines. Jesse Edwards, who founded cardiac pathology at the Mayo Clinic, and William C. Roberts, first head of pathology at the National Heart, Lung, and Blood Institute, are in the best tradition as reflected in this manuscript.
Source: The American Journal of Cardiology - January 31, 2013 Category: Cardiology Authors: Joseph K. Perloff Tags: Historical Study Source Type: research

Clinicopathological and prognostic significance of HIF-1α and HIF-2α expression in small cell lung cancer.
Abstract Previous work from our laboratory has demonstrated that urokinase plasminogen activator receptor (uPAR) may be a potential stem-like cell marker in SCLC. Hypoxia inducible factor (HIF) has been shown to transcriptionally regulate uPAR expression. Therefore, the aim of this study was to evaluate the relationship between HIF-1α/HIF-2α and uPAR expression, and to investigate the role of HIF-1α/HIF-2α in the clinical pathology and prognosis of patients with SCLC. Immunohistochemical analysis showed that HIF-1α/HIF-2α staining was mainly present in the nuclei of cancer cells. HIF-1α-positive cells were d...
Source: Pathology, Research and Practice - January 31, 2013 Category: Pathology Authors: Luan Y, Gao C, Miao Y, Li Y, Wang Z, Qiu X Tags: Pathol Res Pract Source Type: research

LONG-TERM REMISSION AND RECURRENCE RATES IN CUSHING'S DISEASE: PREDICTIVE FACTORS IN A SINGLE-CENTRE STUDY.
Conclusions:Life-long follow-up for patients with CD appears essential, particularly for patients who have shown rapid recovery of their axis. The strict criteria previously used for 'apparent cure' do not appear to necessarily predict a lower recurrence rate. PMID: 23371975 [PubMed - as supplied by publisher]
Source: European Journal of Endocrinology - January 31, 2013 Category: Endocrinology Authors: Alexandraki KI, Kaltsas G, Isidori AM, Storr HL, Afshar F, Sabin H, Akker SA, Chew S, Drake W, Monson JP, Besser MG, Grossman A Tags: Eur J Endocrinol Source Type: research

Impact of single nucleotide polymorphism in tumor necrosis factor-α gene 308G/A in Egyptian asthmatic children and wheezing infants.
Abstract Bronchial asthma is a common disease with multiple determinants that include genetic variation. Although tumor necrosis factor alpha (TNF-α) is a major pro-inflammatory cytokine, the functions of genetic polymorphisms in this cytokine has not been thoroughly examined in the context of asthma pathology. Therefore, we aimed to investigate whether single nucleotide polymorphism (SNP) in TNF-α is associated with asthma and wheezing and whether the association is related to the severity of the disease and other epidemiological factors. Frequencies of TNF-α-308G/A polymorphism were compared in 100 asthmatic c...
Source: Human Immunology - January 31, 2013 Category: Allergy & Immunology Authors: Shaker OG, Sadik NA, El-Hamid NA Tags: Hum Immunol Source Type: research

Interobserver variability in grading transbronchial lung biopsies after lung transplantation.
CONCLUSION: These results expand upon previous reports of interobserver variability in grading transbronchial biopsies after lung transplantation. Given the variability in the grading transbronchial biopsies, we advocate further education of the histopathologic findings in lung transplant biopsies as well as revisiting the current criteria for grading transbronchial biopsies in order to improve concordance among lung transplant pathologists. PMID: 23370547 [PubMed - as supplied by publisher]
Source: Chest - January 31, 2013 Category: Respiratory Medicine Authors: Bhorade SM, Husain AN, Liao C, Li LC, Ahya VN, Baz MA, Valentine VG, Love RB, Seethamraju H, Alex CG, Bag R, Deoliveira NC, Vigneswaran WT, Garrity ER, Arcasoy SM Tags: Chest Source Type: research

Comparison of the Berlin Definition for Acute Respiratory Distress Syndrome with Autopsy.
CONCLUSIONS: Histopathological findings were correlated to severity and duration of ARDS. Using clinical criteria the revised Berlin definition for ARDS allowed the identification of severe ARDS of more 72 hours as a homogeneous group of patients characterized by a high proportion of DAD. PMID: 23370917 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 31, 2013 Category: Respiratory Medicine Authors: Thille AW, Esteban A, Fernández-Segoviano P, Rodriguez JM, Aramburu JA, Peñuelas O, Cortés-Puch I, Cardinal-Fernández P, Lorente JA, Frutos-Vivar F Tags: Am J Respir Crit Care Med Source Type: research

Diffusion‐weighted imaging of the prostate: Comparison of b1000 and b2000 image sets for index lesion detection
Conclusion:Use of a b‐value of 2000 s/mm2 compared with a b‐value of 1000 s/mm2 resulted in improved tumor sensitivity and higher tumor‐to‐PZ contrast on the acquired DW images, although performance of the ADC maps corresponding with the two b‐values was similar. Correlation with tumor size was greater for either ADC map than for either acquired DW image set. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc.
Source: Journal of Magnetic Resonance Imaging - January 31, 2013 Category: Radiology Authors: Andrew B. Rosenkrantz, Nicole Hindman, Ruth P. Lim, Kasturi Das, James S. Babb, Thais C. Mussi, Samir S. Taneja Tags: Original Research Source Type: research

The concept of the onychodermis (specialized nail mesenchyme): an embryological assessment and a comparative analysis with the hair follicle
ConclusionsThe concept of the onychodermis is equally valid in the developing nail organ where it is also defined by its expression for CD10. Its function may be related to the anchorage of the overlying nail bed but may also involve a more dynamic role in the induction of hard keratins in the latter, contributing to the formation of the nail plate.
Source: Journal of Cutaneous Pathology - January 31, 2013 Category: Pathology Authors: Klaus Sellheyer, Paula Nelson Tags: Original Article Source Type: research

Does the calcification of adamantinomatous craniopharyngioma resemble the calcium deposition of osteogensis/odontogenesis?
ConclusionsOur study indicated, for the first time, that osteogenic factor Bmp2 may play an important role in the calcification of ACP via autocrine or paracrine mechanisms. Given the presence of osteogenic markers (Runx2 and Osterix), CP cells could differentiate into an osteoblast‐like lineage, and the process of CP calcification resembles that which occurs in osteogenesis/odontogenesis.© 2012 Blackwell Publishing Ltd
Source: Histopathology - January 31, 2013 Category: Pathology Authors: Qi Song‐tao, Yan Xiao‐rong, Pan Jun, Deng Yong‐jian, Liang Jin, Huang Guang‐long, Lu Yun‐tao, Ruan Jian, Li Xiang‐zhao, Xu Jia‐ming Tags: Original Article Source Type: research

Peritoneal adhesion index (PAI): proposal of a score for the "ignored iceberg" of medicine and surgery
Peritoneal adhesions describe a condition in which pathological bonds form between the omentum, the small and large bowels, the abdominal wall, and other intra-abdominal organs. Different classification systems have been proposed, but they do not resolve the underlying problem of ambiguity in the quantification and definition of adhesions. We therefore propose a standardized classification system of adhesions to universalize their definition based on the macroscopic appearance of adhesions and their diffusion to different regions of the abdomen. By scoring with these criteria, the peritoneal adhesion index (PAI) can range ...
Source: World Journal of Emergency Surgery - January 31, 2013 Category: Emergency Medicine Authors: Coccolini FedericoAnsaloni LucaManfredi RobertoCampanati LucaPoiasina EliaBertoli PaoloGiulii MichelaSartelli MassimoDi SalomoneCucchi MicheleLazzareschi DanielPisano MicheleCatena Fausto Source Type: research

Metastatic urachal carcinoma in bronchial brush cytology
We present a case of metastatic urachal adenocarcinoma in bronchial brushings and review the use of immunohistochemistry in its diagnosis. A 47-year-old female was seen initially in 2007 with adenocarcinoma of the bladder dome for which she underwent partial cystectomy. She presented in 2011 with a left lung mass and mediastinal adenopathy. Bronchoscopy showed an endobronchial lesion from which brushings were obtained. These showed numerous groups of columnar cells with medium sized nuclei and abundant cytoplasm. The cells were positive for CK20 and CDX2 and negative for CK7. The cytomorphological findings were similar to ...
Source: CytoJournal - January 31, 2013 Category: Pathology Authors: Fatima Zahra AlyAbeer Z TabbarahLysandra Voltaggio Source Type: research

Oncocytic follicular nodules of the thyroid with or without chronic lymphocytic thyroiditis: An institutional experience
Conclusions: Based on this study, nodule size and not CLT appears to be an important clinicopathologic features in the management of thyroid FNA specimens diagnosed as OFN.
Source: CytoJournal - January 31, 2013 Category: Pathology Authors: Sule CanberkA Carruth GriffinAbha GoyalHe WangKathleen MontoneVirginia LiVolsiZubair Baloch Source Type: research

Monoclonal antibodies selective for α‐synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and transgenic mice expressing the disease‐causing A30P mutation
Abstract Inclusions of intraneuronal alpha‐synuclein (α‐synuclein) can be detected in brains from patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The aggregation of α‐synuclein is a central feature of the disease pathogenesis. Among the different α‐synuclein species, large oligomers/protofibrils have particular neurotoxic properties and should therefore be suitable as both therapeutic and diagnostic targets. Two monoclonal antibodies, mAb38F and mAb38E2, with high affinity and strong selectivity for large α‐synuclein oligomers were generated. These antibodies, which do not bind amy...
Source: Journal of Neurochemistry - January 31, 2013 Category: Neurology Authors: Therese Fagerqvist, Veronica Lindström, Eva Nordström, Anna Lord, Stina M E Tucker, Xingjian Su, Charlotte Sahlin, Alex Kasrayan, Jessica Andersson, Hedvig Welander, Thomas Näsström, Mats Holmquist, Heinrich Schell, Philipp J. Kahle, Hannu Kalimo, Chr Tags: Original Article Source Type: research

Cover Image
On the Cover: Posteromedial capsular avulsion inferior to the medial meniscus exposing semimembranosus tendon. A 23-year-old woman who had fallen onto her left knee and had severe pain sought consultation at our institute. Her workup included an MRI that showed some irregularity in the posterior body of the medial meniscus and she underwent surgery. At the time of her knee arthroscopy, a capsular rent was noted at the inferior aspect of the posterior body of her medial meniscus. The tendinous portion of the semimembranosus was visualized through the capsular rent. Despite these findings, the medial meniscus was found to be...
Source: Arthroscopy - January 30, 2013 Category: Surgery Tags: Frontmatter Source Type: research

Sensitivity of Preoperative Magnetic Resonance Imaging and Magnetic Resonance Arthrography in Detection of Panlabral Tears of the Glenohumeral Joint
Conclusions: Combined tears of the anterior, posterior, and superior glenoid labrum are infrequent injuries that are typically not completely defined by either noncontrast MRI or MR arthrography.Level of Evidence: Level III, diagnostic study.
Source: Arthroscopy - January 30, 2013 Category: Surgery Authors: Eric T. Ricchetti, Michael C. Ciccotti, Michael G. Ciccotti, Gerald R. Williams, Mark D. Lazarus Tags: Original Articles Source Type: research

[The relationship between DSM-IV axis II and the anaclitic and introjective personality dimensions].
CONCLUSION: Results are consistent with and provide important empirical support for Blatt’s assumptions concerning an anaclitic and an introjective cluster of personality pathology. PMID: 23315692 [PubMed - in process]
Source: Tijdschrift voor Psychiatrie - January 30, 2013 Category: Psychiatry Authors: Descheemaeker M, Lowyck B, Verhaest Y, Luyten P, Vermote R Tags: Tijdschr Psychiatr Source Type: research

Epigenetic Regulation of the X‐Linked Tumor Suppressors BEX1 and LDOC1 in Oral Squamous Cell Carcinoma
Abstract The strong associations between oral squamous cell carcinoma (OSCC) and dietary habits such as Alcohol consumption (A), Betel quid chewing (B) and Cigarette smoking (C) and its predominance in men have been well‐documented; however, systemic analysis of OSCC is limited. Our study applied high‐throughput screening methods to identify causative epigenetic targets in a cohort of men with ABC‐associated OSCC. We identified BEX1 and LDOC1 as two epigenetically silenced X‐linked tumour suppressors and demonstrated a functional link between the transcription of BEX1 and LDOC1 and promoter hypermethylation. Methyl...
Source: The Journal of Pathology - January 30, 2013 Category: Pathology Authors: Chia‐Huei Lee, Thian‐Sze Wong, Jimmy Yu‐Wai Chan, Shao‐Chun Lu, Pinpin Lin, Ann‐Joy Cheng, Yin‐Ju Chen, Jeffrey Shu‐Ming Chang, Shu‐Huei Hsiao, Yu‐Wei Leu, Chuan‐i Li, Jenn‐Ren Hsiao, Jang‐Yang Chang Tags: Original Article Source Type: research

Involvement of the cholinergic basal forebrain nuclei in spinocerebellar ataxia type 2 (SCA2)
ConclusionsThe findings of the present study (1) indicate that the mutation and pathological process underlying SCA2 play a causative role for this severe degeneration of the cholinergic basal forebrain nuclei and (2) may suggest that degeneration of the cholinergic basal forebrain nuclei per se is not sufficient to cause profound and global dementia detrimental to everyday practice and activities of daily living.
Source: Neuropathology and Applied Neurobiology - January 30, 2013 Category: Neurology Authors: Rüb U, Farrag K, Seidel K, Brunt ER, Heinsen H, Bürk K, Melegh B, Gall C, Auburger G, Bohl J, Korf HW, Hoche F, Dunnen W Tags: Original Article Source Type: research

An Overview of Staining Methods for In-Gel ProteomicsAn Overview of Staining Methods for In-Gel Proteomics
This review compares the characteristics and sensitivity of various staining methods used in gel-based proteomics. Expert Review of Proteomics
Source: Medscape Today Headlines - January 30, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Pathology Laboratories in the United Kingdom Are Bracing for New Payment Methods and More Medical Laboratory Consolidation
Speakers lay out clear path for medical laboratories at the 11th Annual Frontiers in Laboratory Medicine DATELINE: Birmingham, England—Pathology laboratories in the United Kingdom are undergoing change at an unprecedented pace. The impetus for change comes from both a shift in how medical laboratories will be paid, as well as the regional integration of medical [...]
Source: Dark Daily - January 30, 2013 Category: Laboratory Medicine Authors: admin Tags: Coding, Billing, and Collections Compliance, Legal, and Malpractice Digital Pathology Instruments & Equipment Laboratory Hiring & Human Resources Laboratory Instruments & Laboratory Equipment Laboratory News Laboratory Operations Laborator Source Type: news

Drug Addiction Is Likely A Pathology Of Decision Making
Addiction may result from abnormal brain circuitry in the frontal cortex, the part of the brain that controls decision-making. Researchers from the RIKEN Center for Molecular Imaging Science in Japan collaborating with colleagues from the Montreal Neurological Institute of McGill University in Canada report that the lateral and orbital regions of the frontal cortex interact during the response to a drug-related cue and that aberrant interaction between the two frontal regions may underlie addiction...
Source: Health News from Medical News Today - January 30, 2013 Category: Consumer Health News Tags: Alcohol / Addiction / Illegal Drugs Source Type: news

Strain differences in pleural mesothelial cell reactions induced by potassium octatitanate fibers (TISMO) infused directly into the thoracic cavity.
Abstract Although we have previously reported that the fiber-shaped TISMO, morphologically similar to asbestos, can induce a severe mesothelial reaction in A/J mice, it is important to clarify any strain differences. In the present study, female A/J, C3H/HeN, ICR and C57BL/6 mice were therefore employed as test strains. At the beginning of the experiment, all mice underwent a left thoracotomy and direct administration of 3mg of TISMO particles suspended in 0.2ml saline into the left thorax. The experiment was terminated after 21 weeks and all groups were sacrificed and the mesothelium and main organs were examined ...
Source: Experimental and Toxicologic Pathology - January 30, 2013 Category: Pathology Authors: Yokohira M, Nakano Y, Yamakawa K, Kishi S, Ninomiya F, Saoo K, Imaida K Tags: Exp Toxicol Pathol Source Type: research

Mechanistic Insights into Self-Reinforcing Processes Driving Abnormal Histogenesis During the Development of Pancreatic Cancer.
Abstract Pancreatic ductal adenocarcinoma, one of the most feared lethal and painful diseases, is increasing in incidence. The poor prognosis of pancreatic ductal adenocarcinoma-affected patients primarily is owing to our inability to develop effective therapies. Mechanistic studies of genetic, epigenetic, and cell-to-cell signaling events are providing clues to molecular pathways that can be targeted in an attempt to cure this disease. The current review article seeks to draw inferences from available mechanistic knowledge to build a theoretical framework that can facilitate these approaches. This conceptual model...
Source: The American Journal of Pathology - January 30, 2013 Category: Pathology Authors: Iovanna JL, Marks DL, Fernandez-Zapico ME, Urrutia R Tags: Am J Pathol Source Type: research

Application of Interleukin-22 Mediates Protection in Experimental Acetaminophen-Induced Acute Liver Injury.
Abstract Acetaminophen (APAP, paracetamol)-induced hepatotoxicity, although treatable by timely application of N-acetylcysteine, can be fatal. Because it is among the common causes of acute liver failure in intensive care units and in light of its gradually increasing incidence, the need for novel therapeutic strategies aimed at severe intoxication is apparent. Recently, it has been shown that IL-22, a STAT3-activating cytokine, has the capability to mediate liver protection. Herein, the protective potential of IL-22 in murine APAP-induced hepatotoxicity was assessed. Intravenous administration of prophylactic IL-2...
Source: The American Journal of Pathology - January 30, 2013 Category: Pathology Authors: Scheiermann P, Bachmann M, Goren I, Zwissler B, Pfeilschifter J, Mühl H Tags: Am J Pathol Source Type: research

Aberrant Lymphocyte Enhancer-Binding Factor 1 Expression Is Characteristic for Sporadic Burkitt's Lymphoma.
This study supports a functionally important role for LEF1 and its target genes in BLs. PMID: 23375451 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - January 30, 2013 Category: Pathology Authors: Walther N, Ulrich A, Vockerodt M, von Bonin F, Klapper W, Meyer K, Eberth S, Pukrop T, Spang R, Trümper L, Kube D Tags: Am J Pathol Source Type: research

ABCA1 influences neuroinflammation and neuronal death.
Abstract ATP-binding cassette transporter A1 (ABCA1) mediates cellular cholesterol efflux in the brain and influences whole brain cholesterol homeostasis. Activation of liver X receptors (LXRs), transcription factors that increase the expression of cholesterol transport genes including ABCA1, reduces neuroinflammation and pathology in neurodegenerative animal models suggesting that in addition to its involvement in cholesterol transport, ABCA1 may play a role in modulating the inflammatory response in the brain. We investigated the cell-type specific role of ABCA1 in neuroinflammation in vivo using mice specificall...
Source: Neurobiology of Disease - January 30, 2013 Category: Neurology Authors: Karasinska JM, de Haan W, Franciosi S, Ruddle P, Fan J, Kruit JK, Stukas S, Lütjohann D, Gutmann DH, Wellington CL, Hayden MR Tags: Neurobiol Dis Source Type: research

Use of cardiac CT angiography imaging in an epidemiology study - the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy.
Conclusion: Cardiac CTA was safe and afforded a low effective radiation exposure to these asymptomatic research participants and provides valuable cardiovascular endpoints for scientific analysis. The cardiac CTA methodology described here may serve as a reference for use in future epidemiology studies aiming to assess coronary atherosclerosis and cardiac anatomy in low risk populations while minimizing radiation exposure. PMID: 23376648 [PubMed - as supplied by publisher]
Source: The Anatolian Journal of Cardiology - January 30, 2013 Category: Cardiology Authors: Hacıoğlu Y, Gupta M, Choi TY, George RT, Deible CR, Jacobson LP, Witt MD, Palella FJ, Post WS, Budoff MJ Tags: Anadolu Kardiyol Derg Source Type: research

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators.
Abstract Brain iron accumulation has been implicated in a host of chronic neurological diseases including Parkinson's disease (PD). The elevated iron levels observed in the substantia nigra of PD subjects have been suggested to incite the generation of reactive oxygen species and intracellular α-synuclein aggregation, terminating in the oxidative neuronal destruction of this brain area. Thus, elucidation of the molecular mechanisms involved in iron dysregulation and oxidative stress-induced neurodegeneration is crucial step in deciphering PD pathology and in developing novel iron complexing compounds, aimed at res...
Source: Free Radical Biology and Medicine - January 30, 2013 Category: Biology Authors: Weinreb O, Mandel S, Youdim MB, Amit T Tags: Free Radic Biol Med Source Type: research

Prevention of Needle-Tract Seeding by Two-Step Freezing after Lung Cancer Biopsy.
Abstract Fine-needle aspiration biopsy is a method to detect malignancy for undetermined pulmonary nodules, but has the potential to spread malignant cells from the tumor to the pleural cavity or chest wall. We developed a two-step freezing method to avoid needle-tract seeding, by use of percutaneous cryoablation after biopsy but before the biopsy needle was removed. A man aged 72 years was admitted because of a large mass in right upper lobe. After biopsy, the patient underwent surgery. Pathological assessment of the resected tumor showed that tissue around the biopsy probe and cryoprobe had been killed before ne...
Source: Pathology Oncology Research - January 30, 2013 Category: Pathology Authors: Mu F, Liu SP, Zhou XL, Chen JB, Li HB, Zuo JS, Xu KC Tags: Pathol Oncol Res Source Type: research

Presence of clusters of plasmacytoid dendritic cells is a helpful feature for differentiating lupus panniculitis from subcutaneous panniculitis‐like T cell lymphoma
ConclusionWe concluded that presence of clusters of PDCs and certain histological features are helpful for differential diagnosis.© 2013 Blackwell Publishing Ltd
Source: Histopathology - January 30, 2013 Category: Pathology Authors: Jau‐Yu Liau, Shih‐Sung Chuang, Chia‐Yu Chu, Wen‐Hui Ku, Jia‐Huei Tsai, Teng‐Fu Shih Tags: Original Article Source Type: research

Virilizing Sclerosing-Stromal Tumor of the Ovary in a Young Woman With McCune Albright Syndrome: Clinical, Pathological, and Immunohistochemical Studies.
Conclusion:This observation extends the clinical spectrum of ovarian pathology of women with MAS. However, the mechanisms causing this ovarian tumor remain unclear, even if the gsp oncogene has been implicated in the pathogenesis of some gonadal tumors. PMID: 23365131 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - January 30, 2013 Category: Endocrinology Authors: Boussaïd K, Meduri G, Maiza JC, Gennero I, Escourrou G, Bros A, Leguevaque P, Bennet A, Caron P Tags: J Clin Endocrinol Metab Source Type: research

Initial Assessment of the Pathogenic Mechanisms of the Recently Identified Alzheimer Risk Loci
Summary Recent genome wide association studies have identified CLU, CR1, ABCA7 BIN1, PICALM and MS4A6A/MS4A6E in addition to the long established APOE, as loci for Alzheimer's disease. We have systematically examined each of these loci to assess whether common coding variability contributes to the risk of disease. We have also assessed the regional expression of all the genes in the brain and whether there is evidence of an eQTL explaining the risk. In agreement with other studies we find that coding variability may explain the ABCA7 association, but common coding variability does not explain any of the other loci. We were...
Source: Annals of Human Genetics - January 30, 2013 Category: Genetics & Stem Cells Authors: Patrick Holton, Mina Ryten, Michael Nalls, Daniah Trabzuni, Michael E. Weale, Dena Hernandez, Helen Crehan, J. Raphael Gibbs, Richard Mayeux, Jonathan L. Haines, Lindsay A. Farrer, Margaret A. Pericak‐Vance, Gerard D. Schellenberg, , Manuel Ramirez‐Re Tags: Regular manuscript Source Type: research

Pathology: At the heart of the problem
Nature. doi:10.1038/493S10a Author: Cassandra Willyard Research is illuminating the molecular mechanisms that can cascade into debilitating heart disease.
Source: Nature - January 30, 2013 Category: Research Authors: Cassandra Willyard Tags: Outlook Source Type: research

Comparative study of epidermal growth factor receptor mutation analysis on cytology smears and surgical pathology specimens from primary and metastatic lung carcinomas
CONCLUSIONS:The current results indicated that direct extraction and analysis of EGFR mutations from cytology smears can be performed successfully on both a pyrosequencing platform and a real‐time polymerase chain reaction platform with results comparable to those achieved in matched surgical specimens. In fine‐needle aspiration/endobronchial ultrasound samples with limited tissue, cytology smears can be important for molecular analysis. Cancer (Cancer Cytopathol) 2013;. © 2012 American Cancer Society.
Source: Cancer Cytopathology - January 30, 2013 Category: Pathology Authors: Renu Khode, Douglas A. Larsen, Brianne C. Culbreath, Shane Parrish, Kimberly L. Walker, Lubna Sayage‐Rabie, Robert S. Beissner, Arundhati Rao Tags: Original Article Source Type: research

The Aging Eye: Common Degenerative Mechanisms Between the Alzheimer's Brain and Retinal Disease [Review]
Alzheimer's disease (AD) is a common, incurable, and progressive dementia, characterized by loss of learning and memory and the neuropathologic accumulation of amyloid plaques and neurofibrillary tangles in the brain. A number of similarities between AD pathology and several distinct retinal degenerations have been described, particularly with respect to either glaucoma or age-related macular degeneration (AMD), each a leading cause of vision loss and blindness worldwide. Although comparisons between these diseases may provide important new insights into their pathogenic mechanisms, glaucoma and AMD result in markedly diff...
Source: Investigative Ophthalmology - January 30, 2013 Category: Opthalmology Authors: Sivak, J. M. Tags: Review Source Type: research

Genistein, a natural product derived from soybeans, ameliorates polyglutamine‐mediated motor neuron disease
Abstract Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR) gene. The pathologic features of SBMA are motor neuron loss in the spinal cord and brainstem and diffuse nuclear accumulation and nuclear inclusions of mutant AR in residual motor neurons and certain visceral organs. AR‐associated coregulator 70 (ARA70) was the first co‐regulator of AR to be identified, and it has been shown to interact with AR and increase its protein stability. Here, we report that genistein, an isoflavone found in soy, disr...
Source: Journal of Neurochemistry - January 30, 2013 Category: Neurology Authors: Qiang Qiang, Hiroaki Adachi, Zhe Huang, Yue‐Mei Jiang, Masahisa Katsuno, Makoto Minamiyama, Hideki Doi, Shinjiro Matsumoto, Naohide Kondo, Yu Miyazaki, Madoka Iida, Genki Tohnai, Gen Sobue Tags: Original Article Source Type: research

Quality Assessment of Tissue Specimens for Studies of Diabetic Foot Ulcers
Abstract Diabetic Foot Ulcers (DFUs) represent an important clinical problem resulting in significant morbidity and mortality. Ongoing translational research studies strive to better understand molecular/cellular basis of DFU pathology that may lead to identification of novel treatment protocols. Tissue at the non‐healing wound edge has been identified as one of major contributors to the DFU pathophysiology that provides important tool for translational and clinical investigations. To evaluate quality of tissue specimens and their potential use we obtained 81 DFU specimens from 25 patients and performed histological anal...
Source: Experimental Dermatology - January 30, 2013 Category: Dermatology Authors: Olivera Stojadinovic, Jennifer N. Landon, Katherine A. Gordon, Irena Pastar, Julia Escandon, Alejandra Vivas, Andrea D. Maderal, David J. Margolis, Robert S. Kirsner, Marjana Tomic‐Canic Tags: Methods Letter to the Editors Source Type: research

Stevens‐Johnson Syndrome associated with mogamulizumab treatment of Adult T‐cell leukemia/lymphoma
We report an ATL patient suffering from Stevens‐Johnson Syndrome (SJS) during mogamulizumab (humanized anti‐CCR4 monoclonal antibody) treatment. There was a durable significant reduction of the CD4+CD25highFOXP3+ regulatory T (Treg) cell　subset in the patient′s PBMC, and the affected inflamed skin almost completely lacked FOXP3‐positive cells. This implies an association between reduction of the Treg subset by mogamulizimab and occurrence of SJS. The present case should contribute not only to our understanding of human pathology resulting from therapeutic depletion of Treg cells, but also alert us to the possibil...
Source: Cancer Science - January 30, 2013 Category: Cancer & Oncology Authors: Takashi Ishida, Asahi Ito, Fumihiko Sato, Shigeru Kusumoto, Shinsuke Iida, Hiroshi Inagaki, Akimichi Morita, Shiro Akinaga, Ryuzo Ueda Tags: Case Report Source Type: research

UtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation
Conclusions: This novel artificial molecule may represent an improved platform for the development of future applications in DMD treatment.
Source: BMC Molecular Biology - Latest articles - January 30, 2013 Category: Molecular Biology Authors: Annalisa OnoriCinzia PisaniGeorgios StrimpakosLucia MonacoElisabetta MatteiClaudio PassanantiNicoletta Corbi Source Type: research

Manganese toxicity in the CNS: the glutamine/glutamate‐γ‐aminobutyric acid cycle
Abstract Manganese (Mn) is an essential trace element that is required for maintaining proper function and regulation of numerous biochemical and cellular reactions. Despite its essentiality, at excessive levels Mn is toxic to the CNS. Increased accumulation of Mn in specific brain regions, such as the substantia nigra, globus pallidus and striatum, triggers neurotoxicity resulting in a neurological brain disorder, termed manganism. Mn has been also implicated in the pathophysiology of several other neurodegenerative diseases. Its toxicity is associated with disruption of the glutamine (Gln)/glutamate (Glu)‐γ‐aminobut...
Source: Journal of Internal Medicine - January 30, 2013 Category: Internal Medicine Authors: Marta Sidoryk‐Wegrzynowicz, Michael Aschner Tags: Review Source Type: research

Quality assessment metrics for whole genome gene expression profiling of paraffin embedded samples
Conclusion: Proper assessment of array quality within a research study is crucial for controlling unwanted variability in the data. The metrics proposed in this paper have direct biological interpretations and can be used to identify arrays that should either be removed from analysis all together or down-weighted to reduce their influence in downstream analyses.
Source: BMC Research Notes - January 30, 2013 Category: Research Authors: Douglas MahoneyTerry TherneauS AndersonJin JenJean-Pierre KocherMonica ReinholzEdith PerezJeanette Eckel-Passow Source Type: research

ProEx C as an adjunct marker to improve cytological detection of urothelial carcinoma in urinary specimens
CONCLUSIONSProEx C stain is a useful adjunct test to urine cytologic analysis, even in specimens with limited cellularity. In urinary smears, this test is most useful in stratification of the “atypical” diagnoses into benign and malignant subsets. To the authors' knowledge, this is the first study of ProEx C application in urine cytology as an adjunct marker for detection of urothelial carcinoma. Cancer (Cancer Cytopathol) 2013. © 2013 American Cancer Society.
Source: Cancer Cytopathology - January 30, 2013 Category: Pathology Authors: Neda A. Moatamed, Jian‐Yu Rao, Serge Alexanian, Melissa Cobarrubias, Mary Levin, David Lu, Sophia K. Apple Tags: Original Article Source Type: research

Expression of c‐Jun and Sox‐2 in human schwannomas and traumatic neuromas
ConclusionsWe have demonstrated increased expression of c‐Jun and Sox‐2 in schwannoma compared to traumatic neuroma. There was no expression of c‐Jun and Sox‐2 in a histologically normal peripheral nerve.
Source: Histopathology - January 30, 2013 Category: Pathology Authors: Aditya Shivane, David B Parkinson, Sylwia Ammoun, Clemens O Hanemann Tags: Original Article Source Type: research

Disturbed Sleep in Parkinson's disease – anatomical and pathological correlates
ConclusionsPathological changes in these structures, residing in the brain circuitry relating to sleep physiology, strongly predict the presence of sleep disturbances in PD.
Source: Neuropathology and Applied Neurobiology - January 30, 2013 Category: Neurology Authors: M.E. Kalaitzakis, S.M. Gentleman, R.K.B. Pearce Tags: Original Article Source Type: research

FDA Approves Retinal Photo App for iPhone FDA Approves Retinal Photo App for iPhone
Physicians who monitor patients for retinal pathology now have help from a new FDA-approved system: an adapter and an app that can record, store, print, and email fundus photos taken with the iPhone. FDA Approvals
Source: Medscape Today Headlines - January 29, 2013 Category: Consumer Health News Tags: Ophthalmology News Alert Source Type: news

Tips and tricks to avoid periprocedural neurological complications in carotid artery stenting.
Abstract Execution of carotid artery stenting (CAS) requires not only excellent manual dexterity, and a high level of competence, but also in-depth knowledge of the carotid pathology, of the materials available on the market and of the different techniques to apply in given situations. Actually each individual moment of the procedure can be determining for the final result. This review describes each individual step of CAS, including arterial access, carotid engagement, pre-dilatation, the characteristics and use of cerebral protection devices, stent selection and deployment, and post-dilatation. Technical notes an...
Source: The Journal of Cardiovascular Surgery - January 29, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Setacci C, de Donato G, Setacci F, Sirignano P, Galzerano G, Kamargianni V, Cappelli A Tags: J Cardiovasc Surg (Torino) Source Type: research