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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 24.
The correlation of research diagnostic criteria for temporomandibular disorders and magnetic resonance imaging: a study of diagnostic accuracy
Conclusions: Our data suggest that RDC/TMD is a good research tool, but the high rate of false-positive results limits its use in clinical practice.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 14, 2013 Category: ENT & OMF Authors: Alessandra Pucci Mantelli Galhardo, Claudia da Costa Leite, Eloisa Maria Mello Santiago Gebrim, Regina Lucia Elia Gomes, Marcio Katsuyoshi Mukai, Claudio Akira Yamaguchi, Wanderley Marques Bernardo, José Maria Soares, Edmund Chada Baracat, Carlos Gil Tags: Oral and Maxillofacial Radiology Source Type: research
Real-time ultrasonographic visualization for guided inferior alveolar nerve injection
Conclusions: We hypothesize that ultrasound-guided IAN block may be feasible in humans using our technique.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 14, 2013 Category: ENT & OMF Authors: Brian Chanpong, Raymond Tang, Andrew Sawka, Claudia Krebs, Himat Vaghadia Tags: Oral and Maxillofacial Radiology Source Type: research
Can clinical and radiological features predict recurrence in solitary keratocystic odontogenic tumors?
Introduction: The solitary keratocystic odontogenic tumor (KCOT) is a neoplasm, which recurs in 28% of cases. The purpose of this study is to determine whether clinicoradiographic features can predict recurrence. Material and Methods: From 2000 to 2009, 106 solitary KCOTs were retrieved from the Oral Biology Service of British Columbia. Among 58 KCOTs including all recurrent KCOTs (rKCOT) and nonrecurrent KCOTs (nrKCOT) (followed up for at least 5 years), only 29 had radiographs (rKCOT, 18; nrKCOT, 11). Results: Patients with recurrences were significantly older than those without. Interestingly, those cases, which we...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 14, 2013 Category: ENT & OMF Authors: D. MacDonald, Y. Gu, L. Zhang, C. Poh Tags: Oral and Maxillofacial Radiology Source Type: research
Magnetic resonance imaging–based tumor volume measurements predict outcome in patients with squamous cell carcinoma of the mandible
Conclusions: Tumor volume was a more useful predictor of outcome than the current clinical or pathologic TNM staging, considering the automatic up-staging of tumors involving mandibular bone to T4 tumors.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 14, 2013 Category: ENT & OMF Authors: Karen A. Eley, Stephen R. Watt-Smith, Stephen J. Golding Tags: Oral and Maxillofacial Radiology Source Type: research
Evidence for loss of heterozygosity (LOH) at chromosomes 9p and 17p in oral granular cell tumors: a pilot study
Conclusions: The present study shows LOH at chromosomes 9p and 17p in oral GCTs.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 14, 2013 Category: ENT & OMF Authors: Carolina Cavaliéri Gomes, Thiago Fonseca-Silva, Ricardo Santiago Gomez Tags: Oral and Maxillofacial Pathology Source Type: research
Microscopic diversity in oral Kaposi sarcoma
Kaposi sarcoma is the most common HIV-associated neoplasm, frequently presenting with oral mucosal involvement. This retrospective study aimed to assess and highlight the histomorphological spectrum of oral Kaposi sarcoma. A total of 135 cases diagnosed between 1990 and 2011 were retrieved from the archives of the Oral and Dental Hospital of the University of Pretoria, South Africa. Following histologic review, each case was placed into 1 of 7 categories based on the predominant pattern of growth. These histologic divisions included lesions designated as solid, lymphangioma-like, telangiectatic, desmoplastic, lymphangiecta...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 14, 2013 Category: ENT & OMF Authors: Belinda K. Bunn, Marianne de Vasconcelos Carvalho, Melanie Louw, Pablo A. Vargas, Willie F. van Heerden Tags: Oral and Maxillofacial Pathology Source Type: research
Ectomesenchymal chondromyxoid tumor of the tongue: insights on histogenesis
Conclusions: The results of the present study indicate that ECTs originate from the ectomesenchymal cells of the neural crest and are similar in their molecular and biological characteristics to undifferentiated mesenchymal stem cells.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 14, 2013 Category: ENT & OMF Authors: Yukio Yoshioka, Ikuko Ogawa, Takaaki Tsunematsu, Taishi Sakaue, Sachiko Yamasaki, Yasuto Fukui, Yasutaka Hayashido, Shigeaki Toratani, Tetsuji Okamoto Tags: Oral and Maxillofacial Pathology Source Type: research
Relationships and our profession
Relationships are everyday, and they can be simple or complex. They exist in the moment, with conversations that create emotions; and they evolve. A simple relationship can become complex and vice versa. Only a few words need be uttered to change a relationship.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 14, 2013 Category: ENT & OMF Authors: Craig S. Miller Tags: Editorial Source Type: research
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 14, 2013 Category: ENT & OMF Source Type: research
Predicted Growth for In Vitro Diagnostics Markets Globally Signals Upward Trajectory in Medical Laboratory Business
Growth in global IVD markets is indicator of increasing demand for clinical laboratory and anatomic pathology testing During the next 24 months, the global in vitro diagnostics (IVD) market is predicted to exceed $50-billion in revenues. However, this robust growth has an upside and a downside for the clinical laboratories and pathology groups that purchase [...]
Source: Dark Daily - January 14, 2013 Category: Laboratory Medicine Authors: admin Tags: Digital Pathology Instruments & Equipment Laboratory Hiring & Human Resources Laboratory Instruments & Laboratory Equipment Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology anatomic pathology Source Type: news
Using Body Mass Index to Predict Optimal Thyroid Dosing after Thyroidectomy
Background: Current postoperative thyroid replacement dosing is weight based, with adjustments made after thyroid-stimulating hormone values. This method can lead to considerable delays in achieving euthyroidism and often fails to accurately dose over- and underweight patients. Our aim was to develop an accurate dosing method that uses patient body mass index (BMI) data.Study Design: A retrospective review of a prospectively collected thyroid database was performed. We selected adult patients undergoing thyroidectomy, with benign pathology, who achieved euthyroidism on thyroid hormone supplementation. Body mass index and e...
Source: Journal of the American College of Surgeons - January 14, 2013 Category: Surgery Authors: Kristin A. Ojomo, David F. Schneider, Alexandra E. Reiher, Ngan Lai, Sarah Schaefer, Herbert Chen, Rebecca S. Sippel Tags: Original Scientific Articles Source Type: research
Parkinson’s disease – How do sleep and dementia interact?
Although Parkinson’s disease (PD) has been classically considered a motor disease, it has now become abundantly clear that PD pathology affects numerous non-motor structures, many of which, may be affected before motor structures degenerate . One of the most prominent categories of non-motor symptoms is sleep dysfunction. PD patients have a high prevalence of insomnia (particularly sleep maintenance insomnia) and excessive daytime somnolence. In addition, REM sleep behavior disorder (RBD) occurs in up to 50% . RBD has attracted considerable interest in the PD community because idiopathic RBD strongly predicts development...
Source: Sleep Medicine - January 14, 2013 Category: Sleep Medicine Authors: Ronald B. Postuma, Jean-Francois Gagnon Tags: Editorials Source Type: research
2013 Society for Cardiovascular Pathology Distinguished Achievement Award Recipient — Michael A. Gimbrone, Jr., M.D.
As an early pioneer in the field of Vascular Biology, and leading investigator and thought leader in this discipline for over 4 decades, Michael A. Gimbrone, Jr., M.D., is a most appropriate recipient of the 2013 Distinguished Achievement Award of the Society for Cardiovascular Pathology. Dr. Gimbrone's research focuses on the cellular and molecular mechanisms of vascular disease, in particular, the role of the vascular endothelial cell in complex disease processes such as atherosclerosis, thrombosis and inflammation. His work has been a guiding force in both basic and applied research in vascular biology and in cardiovascular medicine.
Source: Cardiovascular Pathology - January 14, 2013 Category: Cardiology Authors: Frederick J. Schoen Tags: Editorial Source Type: research
Protective effect of lycopene against ochratoxin A induced renal oxidative stress and apoptosis in rats.
This study was designed to investigate the possible protective effect of lycopene against the renal toxic effects of OTA. Male Sprague-Dawley rats (<200g, n=6) were treated with OTA (0.5mg/kg/day) and/or lycopene (5mg/kg/day) by gavage for 14 days. Histopathological examinations were performed and apoptotic cell death in both cortex and medulla was evaluated by TUNEL assay. Besides, biochemical parameters and activities of renal antioxidant selenoenzymes [glutathione peroxidase 1 (GPx1), thioredoxin reductase (TrxR)], catalase (CAT), superoxide dismutase (SOD); concentrations of total glutathione (GSH), and malondialdeh...
Source: Experimental and Toxicologic Pathology - January 14, 2013 Category: Pathology Authors: Palabiyik SS, Erkekoglu P, Zeybek ND, Kizilgun M, Baydar DE, Sahin G, Giray BK Tags: Exp Toxicol Pathol Source Type: research
Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the esophagogastric junction with microsatellite instability, K-ras wild type.
Abstract A 60-year-old male was admitted to our hospital for gastric cancer. Considering his general condition, total gastrectomy and dissection of regional lymph nodes were performed. Macroscopically, a 45mm×20mm×10mm-sized, ulcero-infiltrative tumor located in the esophagogastric junction was described. Microscopically, the tumor consisted of a poorly differentiated adenocarcinoma intermingled with dense lymphoid infiltration predominantly composed of T-cell lymphocytes. The tumor cells infiltrated the submucosa, muscularis and subserosal layers of the stomach, respectively the esophageal adventitia. No metasta...
Source: Pathology, Research and Practice - January 14, 2013 Category: Pathology Authors: Gurzu S, Szentirmay Z, Bara T, Turcu M, Toth E, Bara T, Jung I Tags: Pathol Res Pract Source Type: research
Expression of Shh and Wnt Signaling Pathway Proteins in Eyelid Sebaceous Gland Carcinoma: Clinicopathologic Study [Anatomy and Pathology]
Conclusions. The group with metastasis showed higher expression levels of Shh, ABCG2, and Wnt than did the group without metastasis, and patients with strong ABCG2 expression, Wnt, or LRP expression showed higher cumulative incidence of lymph node or distant metastasis, implying that activation of the Shh and Wnt signaling pathway is associated with aggressive behavior of the tumor.
Source: Investigative Ophthalmology - January 14, 2013 Category: Opthalmology Authors: Kim, N., Kim, J. E., Choung, H.-K., Lee, M. J., Khwarg, S. I. Tags: Anatomy and Pathology Source Type: research
Analysis of Inflammatory Cells in Uveal Melanoma after Prior Irradiation [Anatomy and Pathology]
Conclusions. Numbers of infiltrating T lymphocytes and macrophages varied widely between tumors, but tumors with high numbers of macrophages also contained more lymphocytes. Irradiation had no effect on the number and type of macrophages, but led to an increased amount of T lymphocytes up to 24 months postirradiation. Because the presence of infiltrating cells was related to the tumor cell type, it is conceivable that the presence of an infiltrate is especially a consequence of the primary tumor characteristics before irradiation.
Source: Investigative Ophthalmology - January 14, 2013 Category: Opthalmology Authors: Vu, T. H. K., Bronkhorst, I. H. G., Versluis, M., Marinkovic, M., van Duinen, S. G., Vrolijk, J., Luyten, G. P. M., Jager, M. J. Tags: Anatomy and Pathology Source Type: research
Decreased skeletal muscle mitochondrial DNA in patients with statin-induced myopathy
Abstract: Statins are widely used to treat hyperlipidemia and lower cardiovascular disease risk. While statins are generally well tolerated, some patients experience statin-induced myopathy (SIM). Statin treatment has been associated with mitochondrial dysfunction and mitochondrial DNA (mtDNA) depletion. In this retrospective study, skeletal muscle biopsies from patients diagnosed with SIM were studied. These were compared with biopsies from patients clinically assessed as having statin-unrelated myopathy but whose biopsy showed no or negligible pathology. For each biopsy sample, mtDNA was quantified relative to nuclear DN...
Source: Journal of the Neurological Sciences - January 14, 2013 Category: Neurology Authors: Henry A.J. Stringer, Gurmeet K. Sohi, John A. Maguire, Hélène C.F. Côté Tags: Original Articles Source Type: research
Clinical Measurement of Scapular Upward Rotation in Response to Acute Subacromial Pain.
CONCLUSION: Acute subacromial pain elicited an increase in scapular upward rotation at all angles of humeral elevation tested. This adaptation to acute experimental pain may provide protective compensation to subacromial structures during humeral elevation.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4276. PMID: 23321770 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Wassinger CA, Sole G, Osborne H Tags: J Orthop Sports Phys Ther Source Type: research
Diagnostic Accuracy of Clinical Tests for Assessment of Hamstring Injury: A Systematic Review.
CONCLUSION: Very few studies have investigated the utilization of clinical special tests for the diagnosis of hamstring injuries. Further studies of higher quality design are suggested prior to advocating independent clinical utilization of these special tests. LEVEL OF EVIDENCE: Diagnosis, Level 2a.J Orthop Sports Phys Ther. Epub 14 January 2013. doi:10.2519/jospt.2013.4343. PMID: 23321899 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 14, 2013 Category: Physiotherapy Authors: Reiman MP, Loudon JK, Goode AP Tags: J Orthop Sports Phys Ther Source Type: research
Tryptophan Inhibits Biofilm Formation by Pseudomonas aeruginosa.
Abstract Biofilm formation by Pseudomonas aeruginosa has been implicated in the pathology of chronic wounds. Both d- and l-isoforms of tryptophan inhibited P. aeruginosa biofilm formation on tissue culture plates, with an equimolar ratio of d- and l-isoforms producing the greatest inhibitory effect. Addition of d-/l-tryptophan to existing biofilms inhibited further biofilm growth and caused partial biofilm disassembly. Tryptophan significantly increased swimming motility, which may be responsible in part for diminished biofilm formation by P. aeruginosa. PMID: 23318791 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - January 14, 2013 Category: Microbiology Authors: Brandenburg KS, Rodriguez KJ, McAnulty JF, Murphy CJ, Abbott NL, Schurr MJ, Czuprynski CJ Tags: Antimicrob Agents Chemother Source Type: research
HNE catabolism and formation of HNE adducts are modulated by beta oxidation of fatty acids in the isolated rat heart.
Abstract We previously reported that a novel metabolic pathway functionally catabolizes 4-hydroxy-2-(E)-nonenal (HNE) via two parallel pathways, which rely heavily on β oxidation pathways. The hypothesis driving the present report is that perturbations of β oxidation will alter the catabolic disposal of HNE, favoring an increase in the concentrations of HNE and HNE modified proteins that may further exacerbate pathology. The current study employed Langendorff perfused hearts to investigate the impact of cardiac injury modeled by ischemia/reperfusion and, in a separate set of perfusions, the effects of elevated li...
Source: Free Radical Biology and Medicine - January 14, 2013 Category: Biology Authors: Li Q, Sadhukhan S, Berthiaume JM, Ibarra RA, Tang H, Deng S, Hamilton E, Nagy LE, Tochtrop GP, Zhang GF Tags: Free Radic Biol Med Source Type: research
Evaluation of two different vacuum-assisted breast biopsy systems: Mammotome(R) system 11G/8G vs. ATEC(R) system 12G/9G.
ConclusionBoth biopsy systems meet all requirements for daily practice and confirm the diagnosis of suspicious microcalcifications. The ATEC(®) system was observed to be faster but this difference of about 250 s might not be relevant in daily practice. The Mammotome(®) system provides a better histologic quality of tissue samples. PMID: 23319718 [PubMed - as supplied by publisher]
Source: Acta Radiologica - January 14, 2013 Category: Radiology Authors: Order BM, Schaefer PJ, Peters G, Eckmann-Scholz C, Hilpert F, Strauss A, Warneke V, Mathiak M, Heller M, Jonat W, Schaefer FK Tags: Acta Radiol Source Type: research
Systematic review and meta-analysis of the influence of circumferential resection margin involvement on survival in patients with operable oesophageal cancer.
CONCLUSION: CRM involvement is an important predictor of poor prognosis. CAP criteria differentiate a higher-risk group than RCP criteria, but overlook a patient group with similar poor outcomes. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 23319427 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - January 14, 2013 Category: Surgery Authors: Chan DS, Reid TD, Howell I, Lewis WG Tags: Br J Surg Source Type: research
Use of Lung Weight as Biomarker for Assessment of Lung Toxicity in Rat Inhalation Studies.
Abstract Subacute inhalation study (1 week or 2 weeks) is an important process for screening out inhaled compounds causing lung irritation. To investigate whether the lung weight can be used as an indicator for acute lung injury, we have analyzed retrospectively the lung weight data from 30 studies in rats exposed to dry powder inhalation. The lung weight change was correlated with lung histopathology in the majority of studies (25 of 30), showing as either both changed or both unchanged. The sensitivity and specificity of using the weight change in lungs as biomarker for predicting lung histopathology in these stu...
Source: Toxicologic Pathology - January 14, 2013 Category: Pathology Authors: Wahlström E, Ollerstam A, Sundius L, Zhang H Tags: Toxicol Pathol Source Type: research
British Society for Matrix Biology – Spring 2012 Meeting Report
Source: International Journal of Experimental Pathology - January 14, 2013 Category: Pathology Tags: Abstract Source Type: research
Experimental development of bisphosphonate‐related osteonecrosis of the jaws in rodents
Summary Osteonecrosis of the jaw (ONJ) following the use of bisphosphonates has become of increased interest in the scientific community, due in particular to its as‐yet‐unsolved pathogenesis. An experimental model of ONJ was induced in normal male rats [alendronate (ALN); 1 mg/Kg/day; n = 10] and matched controls (saline solution; n = 10). After 60 days of drug treatment, all animals were subjected to extractions of the left first lower molars and were euthanized at 3 and 28 days postsurgery. The following analyses were performed: (i) descriptive and quantitative (scores) histological evaluation, (ii) stereomet...
Source: International Journal of Experimental Pathology - January 14, 2013 Category: Pathology Authors: Nicolau Conte Neto, Luis C. Spolidorio, Cleverton R. Andrade, Alliny S. Bastos, Morgana Guimarães, Elcio Marcantonio Tags: Original Article Source Type: research
Premature death of TDP‐43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis
Summary Abnormal distribution, modification and aggregation of transactivation response DNA‐binding protein 43 (TDP‐43) are the hallmarks of multiple neurodegenerative diseases, especially frontotemporal lobar degeneration with ubiquitin‐positive inclusions (FTLD‐U) and amyotrophic lateral sclerosis (ALS). Transgenic mouse lines overexpressing wild‐type or mutant TDP‐43 exhibit ALS‐like symptom, motor abnormalities and early paralysis followed by death. Reports on lifespan and phenotypic behaviour in Prp‐TDP‐43 (A315T) vary, and these animals are not fully characterized. Although it has been proposed that...
Source: International Journal of Experimental Pathology - January 14, 2013 Category: Pathology Authors: Mohammad A. Esmaeili, Marzieh Panahi, Shilpi Yadav, Leah Hennings, Mahmoud Kiaei Tags: Original Article Source Type: research
Changes in liver gluconeogenesis during the development of Walker‐256 tumour in rats
Summary Few studies have investigated liver gluconeogenesis in cancer and there is no agreement as to whether the activity of this pathway is increased or decreased in this disease. The aim of this study was to evaluate gluconeogenesis from alanine, pyruvate and glycerol, and related metabolic parameters in perfused liver from Walker‐256 tumour‐bearing rats on days 5 (WK5 group), 8 (WK8 group) and 12 (WK12 group) of tumour development. There was reduction (P < 0.05) of liver glucose production from alanine and pyruvate in WK5, WK8 and WK12 groups, which was accompanied by a decrease (P < 0.05) in oxygen consu...
Source: International Journal of Experimental Pathology - January 14, 2013 Category: Pathology Authors: Carolina Campos Lima Moreira, Priscila Cassolla, Ana Paula Segantini Dornellas, Hely Morais, Camila Oliveira Souza, Glaucia Regina Borba‐Murad, Roberto Barbosa Bazotte, Helenir Medri Souza Tags: Original Article Source Type: research
Lymphangiogenesis and Prognostic Significance of Vascular Endothelial Growth Factor C in Gastro‐oesophageal Junction Adenocarcinoma
Summary Vascular endothelial growth factor C (VEGF‐C) is a crucial regulator of the development of lymphatic vessels and is involved in the lymph node metastasis of cancer. The levels of VEGF‐C expression and lymphatic vessel density (LVD) in 128 gastro‐oesophageal junction adenocarcinoma (GEJA) tissues were examined by immunohistochemistry and analysed for their association with clinicopathological features and disease‐free survival. We found that 75.0% of tumour samples displayed strong immunoreactivity to VEGF‐C. The levels of VEGF‐C expression in the tumour tissues were associated with the stages of the cli...
Source: International Journal of Experimental Pathology - January 14, 2013 Category: Pathology Authors: Liang‐Xi Xie, Tian‐Tian Zhai, Li‐Ping Yang, Eleanor Yang, Xiao‐Hui Zhang, Jiong‐Yu Chen, Hao Zhang Tags: Original Article Source Type: research
Predictive biomarkers for Barrett's esophagus: so near and yet so far
Summary Barrett's esophagus (BE) is the strongest risk factor for the development of esophageal adenocarcinoma. However, the risk of cancer progression is difficult to ascertain in individuals, as a significant number of patients with BE do not necessarily progress to esophageal adenocarcinoma. There are several issues with the current strategy of using dysplasia as a marker of disease progression. It is subject to sampling error during biopsy acquisition and interobserver variability among gastrointestinal pathologists. Ideal biomarkers with high sensitivity and specificity are needed to accurately detect high‐risk BE p...
Source: Diseases of the Esophagus - January 14, 2013 Category: Gastroenterology Authors: M. R. Timmer, G. Sun, E. C. Gorospe, C. L. Leggett, L. Lutzke, K. K. Krishnadath, K. K. Wang Tags: Review article Source Type: research
New NBIA subtype: Genetic, clinical, pathologic, and radiographic features of MPAN
Conclusions: MPAN is caused by mutations in C19orf12 leading to NBIA and prominent, widespread Lewy body pathology. The clinical phenotype is recognizable and distinctive, and joins pantothenate kinase–associated neurodegeneration and PLA2G6-associated neurodegeneration as one of the major forms of NBIA.
Source: Neurology - January 14, 2013 Category: Neurology Authors: Hogarth, P., Gregory, A., Kruer, M. C., Sanford, L., Wagoner, W., Natowicz, M. R., Egel, R. T., Subramony, S. H., Goldman, J. G., Berry-Kravis, E., Foulds, N. C., Hammans, S. R., Desguerre, I., Rodriguez, D., Wilson, C., Diedrich, A., Green, S., Tran, H., Tags: Parkinson's disease/Parkinsonism, Basal ganglia ARTICLE Source Type: research
Pancreatic cyst cytology: Optimization of cancer risk profiling
Source: Cancer Cytopathology - January 14, 2013 Category: Pathology Authors: C. Max Schmidt Tags: Clinician's Corner Source Type: research
Stem-cell approach shows promise for Duchenne muscular dystrophy
(University of Illinois at Urbana-Champaign) Researchers have shown that transplanting stem cells derived from normal mouse blood vessels into the hearts of mice that model the pathology associated with Duchenne muscular dystrophy (DMD) prevents the decrease in heart function associated with DMD.
Source: EurekAlert! - Social and Behavioral Science - January 14, 2013 Category: Global & Universal Source Type: news
Primary intestinal lymphangiectasia diagnosed by double-balloon enteroscopy and treated by medium-chain triglycerides: a case report
Conclusion: Intestinal lymphangiectasia can be diagnosed with a double-balloon enteroscopy and multi-dot biopsy, as well as the pathology of small intestinal tissue showing edema of the submucosa and lymphangiectasia. Because intestinal lymphangiectasia can be primary or secondary, the diagnosis of primary intestinal lymphangiectasia must first exclude the possibility of secondary intestinal lymphangiectasia. A positive clinical response to the special diet therapy, namely a low-fat and medium-chain triglyceride diet, can further confirm the diagnosis of primary intestinal lymphangiectasia.
Source: BioMed Central - January 14, 2013 Category: Journals (General) Authors: Yu LaiTao YuXiao-yu QiaoLi-na ZhaoQi-kui Chen Source Type: research
A Desktop Tool for Next-Generation Sequencing Data AnalysisA Desktop Tool for Next-Generation Sequencing Data Analysis
SNVerGUI is an easy-to-use desktop interface which will speed the identification of genomic variants from pooled sequencing and individual sequencing data. Journal of Medical Genetics
Source: Medscape Today Headlines - January 13, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
Human Genetic Variation of CYP450 SuperfamilyHuman Genetic Variation of CYP450 Superfamily
The CYP450 superfamily plays a key role in the metabolism of 90% of drugs currently in use. What role does ethnicity play in influencing the genetic variability of CYP450 enzymes? Pharmacogenomics
Source: Medscape Today Headlines - January 13, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
Virulence Profile of Uropathogenic E. Coli in PakistanVirulence Profile of Uropathogenic E. Coli in Pakistan
This phylogenetic analysis investigated the distribution of virulence genes and cytotoxic effects of uropathogenic E.coli in order to characterize the local isolates in Pakistan. Annals of Clinical Microbiology and Antimicrobials
Source: Medscape Today Headlines - January 13, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
Back pain during growth.
Abstract It is wrong to believe that back pain only burdens adults: the yearly incidence during growth ranges from 10-20%, continuously increasing from childhood to adolescence. Rapid growth-related muscular dysbalance and insufficiency, poor physical condition in an increasingly sedentary adolescent community or - vice versa - high level sports activities, account for the most prevalent functional pain syndromes. In contrast to adults the correlation of radiographic findings with pain is high: the younger the patient, the higher the probability to establish a rare morphologic cause such as benign or malignant tumo...
Source: Swiss Medical Weekly - January 13, 2013 Category: Journals (General) Authors: Hasler CC Tags: Swiss Med Wkly Source Type: research
Transgenic Mice Overexpressing Neuregulin-1 Model Neurofibroma-Malignant Peripheral Nerve Sheath Tumor Progression and Implicate Specific Chromosomal Copy Number Variations in Tumorigenesis.
Abstract Patients with neurofibromatosis type 1 (NF1) develop benign plexiform neurofibromas that frequently progress to become malignant peripheral nerve sheath tumors (MPNSTs). A genetically engineered mouse model that accurately models plexiform neurofibroma-MPNST progression in humans would facilitate identification of somatic mutations driving this process. We previously reported that transgenic mice overexpressing the growth factor neuregulin-1 in Schwann cells (P(0)-GGFβ3 mice) develop MPNSTs. To determine whether P(0)-GGFβ3 mice accurately model human neurofibroma-MPNST progression, cohorts of these anima...
Source: The American Journal of Pathology - January 13, 2013 Category: Pathology Authors: Kazmi SJ, Byer SJ, Eckert JM, Turk AN, Huijbregts RP, Brossier NM, Grizzle WE, Mikhail FM, Roth KA, Carroll SL Tags: Am J Pathol Source Type: research
Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.
Abstract Over 170 mutations in superoxide dismutase-1 (SOD1) have been linked to amyotrophic lateral sclerosis (ALS). The properties of SOD1 mutants differ considerably including copper-binding abilities. Nevertheless, they cause the same disease phenotype, suggesting a common neurotoxic pathway. We have previously reported that copper homeostasis is disturbed in spinal cords of SOD1(G93A) mice. However, it is unknown whether copper dyshomeostasis is induced by other SOD1 mutants. Using the additional mouse strains SOD1(G127insTGGG), SOD1(G85R), and SOD1(D90A), which express SOD1 mutants with different copper-bindi...
Source: Neurobiology of Disease - January 13, 2013 Category: Neurology Authors: Tokuda E, Okawa E, Watanabe S, Ono SI, Marklund SL Tags: Neurobiol Dis Source Type: research
Friedreich Ataxia: Dysarthria Profile and Clinical Data.
Abstract Friedreich ataxia (FRDA) is the most frequent recessive ataxia in the Western world. Dysarthria is a cardinal feature of FRDA, often leading to severe impairments in daily functioning, but its exact characteristics are only poorly understood so far. We performed a comprehensive evaluation of dysarthria severity and the profile of speech motor deficits in 20 patients with a genetic diagnosis of FRDA based on a carefully selected battery of speaking tasks and two widely used paraspeech tasks, i.e., oral diadochokinesis and sustained vowel productions. Perceptual ratings of the speech samples identified respi...
Source: Cerebellum - January 13, 2013 Category: Neuroscience Authors: Brendel B, Ackermann H, Berg D, Lindig T, Schölderle T, Schöls L, Synofzik M, Ziegler W Tags: Cerebellum Source Type: research
Total aortic arch replacement with a novel four-branched frozen elephant trunk graft: first-in-man results [AORTIC SURGERY]
CONCLUSIONS The graft adds to the ‘frozen elephant trunk’ concept for treating the arch and proximal descending aorta. Early experience demonstrates an excellent 30-day survival. Combining the frozen elephant with a four-branched arch graft increases the armament of the surgeon in the treatment of complex and diverse aortic arch pathology.
Source: European Journal of Cardio-Thoracic Surgery - January 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Shrestha, M., Pichlmaier, M., Martens, A., Hagl, C., Khaladj, N., Haverich, A. Tags: AORTIC SURGERY Source Type: research
Rapid onset of fulminant myocarditis portends a favourable prognosis and the ability to bridge mechanical circulatory support to recovery [TX [amp ] MCS]
CONCLUSIONS Fulminant myocarditis is a fatal condition without mechanical support. The rapid onset of symptoms is associated with a complete recovery of myocardial function and VAD explant. The absence of rapid recovery of myocardial function should prompt listing for a heart transplant.
Source: European Journal of Cardio-Thoracic Surgery - January 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Atluri, P., Ullery, B. W., MacArthur, J. W., Goldstone, A. B., Fairman, A. S., Hiesinger, W., Acker, M. A., Woo, Y. J. Tags: TX [amp ] MCS Source Type: research
New insights into bicuspid aortic valve disease: the elongated anterior mitral leaflet [ADULT CARDIAC]
CONCLUSIONS We provide evidence that the cardiovascular alterations observed in the BAV are not limited to the aortic valve or ascending aorta but also involve the AML, and seem to be more pronounced in patients with a BAV with concomitant, clinically significant aortic regurgitation.
Source: European Journal of Cardio-Thoracic Surgery - January 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Charitos, E. I., Hanke, T., Karluss, A., Hilker, L., Stierle, U., Sievers, H.-H. Tags: ADULT CARDIAC Source Type: research
Abundant Hepatic Gaucher-Like Cells Following Chemotherapy and Bone Marrow Transplantation for Hematologic Malignancy: Report of Two Cases
Cells with a resemblance to Gaucher cells, sometimes called pseudo-Gaucher cells, are seen in the bone marrow of some patients with hematologic malignancy or anemia. These cells are derived from cells of the monocytic lineage but do not show the characteristic inclusions of true Gaucher cells when examined by electron microscopy. Large numbers of Gaucher-like cells were found in the livers at autopsy of 2 patients with hematologic malignancy treated with chemotherapy and bone marrow transplant. Knowledge of this phenomenon may be useful in the interpretation of liver biopsy done on a patient with bone marrow transplant.
Source: International Journal of Surgical Pathology - January 13, 2013 Category: Pathology Authors: Stenzel, P., Weeks, D. A. Tags: Case Reports Source Type: research
Neuroendocrine Tumors of the Submandibular Gland: Literature Review and Report of a Case
Primary salivary neuroendocrine neoplasms are extremely rare, with only 1 case of carcinoid tumor and 7 cases of primary large-cell neuroendocrine carcinomas having been reported. Salivary small-cell neuroendocrine carcinomas are more frequent, accounting for less than 2% of all salivary malignancies. In addition to a literature review on the subject, the authors describe a rare case of malignant intermediate-grade neuroendocrine tumor of the submandibular gland.
Source: International Journal of Surgical Pathology - January 13, 2013 Category: Pathology Authors: Petrone, G., Santoro, A., Angrisani, B., Novello, M., Scarano, E., Rindi, G., Lauriola, L. Tags: Case Reports Source Type: research