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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 30.
Evaluation of Histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.
Abstract H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V). Sixteen genes encode histone H3, each variant differing in only a few amino acids. Therefore how mutations in a single H3 gene contribute to carcinogenesis is unknown. H3F3A K27M mutations are predicted to alter methylation of H3K27. H3K27me3 is a repressive mark critical to stem cell maintenance and is mediated by EZH2, a member of the polycomb‐group (PcG) family. We evaluated H3K27me3 and EZH2 expression using immunohistochemistry in 76 pediatric br...
Source: Brain Pathology - January 1, 2013 Category: Neurology Authors: Sriram Venneti, Mihir T. Garimella, Lisa M Sullivan, Daniel Martinez, Jason T. Huse, Adriana Heguy, Mariarita Santi, Craig B. Thompson, Alexander R. Judkins Tags: Research Article Source Type: research
Familial LCAT deficiency: from renal replacement to enzyme replacement.
We present two brothers with considerable variation in the age at which they developed ESRD. Kidney biopsies revealed both tubular and glomerular pathology. To date, no causal therapy is available, yet enzyme replacement therapy is in development. PMID: 23412821 [PubMed - in process]
Source: The Netherlands Journal of Medicine - January 1, 2013 Category: Journals (General) Authors: Stoekenbroek RM, van den Bergh Weerman MA, Hovingh GK, Potter van Loon BJ, Siegert CE, Holleboom AG Tags: Neth J Med Source Type: research
Commentary on “Laparoendoscopic single-site (LESS) partial nephrectomy short-term outcomes.” Rais-Bahrami S, George AK, Montag S, Okhunov Z, Richstone L, The Arthur Smith Institute for Urology, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY: BJU Int 2012 (Epub ahead of print)
We report our experience with LESS-PN with complete pathologic resection and excellent short-term oncologic and renal functional outcomes in the select patient-population who underwent this minimally invasive approach. To present our experience of transumbilical LESS-PN with pathologic and short-term oncologic and renal functional outcomes. In all, 15 LESS-PNs were performed for cT1a tumors between July 2008 and August 2011 by 1 surgeon. All patients underwent transumbilical LESS using a 5mm flexible-tip laparoscope and a combination of flexible and conventional laparoscopic instruments. The technique for transperitoneal L...
Source: Urologic Oncology: Seminars and Original Investigations - January 1, 2013 Category: Urology & Nephrology Authors: Maxwell V. Meng Tags: Urologic Oncology Survey Source Type: research
Commentary on “Off-clamp vs. complete hilar control laparoscopic partial nephrectomy: Comparison by clinical stage.” Rais-Bahrami S, George AK, Herati AS, Srinivasan AK, Richstone L, Kavoussi LR, Arthur Smith Institute for Urology, North Shore-Long Island Jewish Health System, New Hyde Park, NY: BJU Int 2012;109(9):1376–81 (Epub 2011 Oct 12)
Study type—therapy (case series). Level of evidence 4. What's known on the subject? And what does the study add? Minimizing renal ischemia and reperfusion injury is an area of active investigation and is particularly significant in cases of laparoscopic renal surgery where the kidney experiences warm ischemia. Reports of partial clamping, early unclamping, and off-clamp (OC) laparoscopic partial nephrectomy (LPN) have demonstrated potential technical modifications that can offer a protective role in preserving renal function. We investigated OC LPN for tumors with varying clinical stage to determine feasibility, perioper...
Source: Urologic Oncology: Seminars and Original Investigations - January 1, 2013 Category: Urology & Nephrology Authors: Stephen Boorjian Tags: Urologic Oncology Survey Source Type: research
Anatomic features of the cetacean globe
Abstract ObjectiveTo provide measurements of globe dimensions and describe morphological characteristics of the cetacean globe with an emphasis on Bowman's layer and encapsulated sensory corpuscles (ESC) for available cetacean species. Animal studiedCetacean globes housed at the Comparative Ocular Pathology Laboratory of Wisconsin from various odontocete and two mysticete species. ProcedureMeasurements were taken from formalin fixed globes and images of formalin fixed globes with embedded rulers. Histological sections of globes were used to count ESC and measure Bowman's layer. ResultsThe horizontal diameter of the globe w...
Source: Veterinary Ophthalmology - January 1, 2013 Category: Veterinary Research Authors: Sarah Miller, Don Samuelson, Richard Dubielzig Tags: Original Article Source Type: research
Nutritional composition analysis of meat from human lactoferrin transgenic bulls.
Abstract Transgenic technology has many potential advantages in food production. However, the transgenic technology process may influence the composition of food products derived from genetically engineered (GE) animals, which may be adverse to human health. Therefore, it is very important to research the compositions of GE animal products. Here, we analyzed the compositions of meat from the offspring of human lactoferrin (hLF) transgenic cows, which can express human lactoferrin proteins in their mammary gland. Six hLF transgenic bulls and three wide-type (WT) bulls, 10 months of age, were slaughtered for meat com...
Source: Animal Biotechnology - January 1, 2013 Category: Biotechnology Authors: Zhao J, Xu J, Wang J, Li N Tags: Anim Biotechnol Source Type: research
Mechanism of Induction of Oxidative Stress in Liver Mitochondria by Low Concentrations of tert-Butyl Hydroperoxide.
Abstract The mechanism of the effect of tert-butyl hydroperoxide (tBHP) on the kinetics of decrease in liver mitochondrial ΔΨ (transmembrane electric potential) in response to successive additions of tBHP in low concentrations has been studied. FeSO(4) was found to increase significantly the damaging effect of tBHP; this effect was shown to increase in the presence of low concentrations of Ca2+ starting from 2 µM CaCl(2). Cyclosporin A prevents these effects. The data show that the damaging effect of low concentrations of tBHP in the course of pyruvate oxidation in isolated liver mitochondria is caused by the o...
Source: Biochemistry (Moscow) - January 1, 2013 Category: Biochemistry Authors: Fedotcheva NI, Mokhova EN Tags: Biochemistry (Mosc) Source Type: research
Tapetal dysplasia in a Swedish Vallhund dog
ConclusionsBased on microscopic and ultrastructural findings, this is the first report of tapetal dysplasia in a dog.
Source: Veterinary Ophthalmology - January 1, 2013 Category: Veterinary Research Authors: Erin M. Scott, Leandro B.C. Teixeira, Richard R. Dubielzig, András M. Komáromy Tags: Case Report Source Type: research
Closing the personalized medicine information gap: HER2 test documentation practice.
Conclusions: Despite a universal testing policy, the rate of centralized HER2 test documentation was lower than expected and related to disease severity. Differences in regional reporting likely reflect ascertainment bias inherent to centralized pathology reporting rather than testing access. Improved HER2 reporting is encouraged for cancer registration, quality-of-care measurement, and program evaluation. PMID: 23379747 [PubMed - in process]
Source: The American Journal of Managed Care - January 1, 2013 Category: Health Management Authors: Ferrusi IL, Earle CC, Trudeau M, Leighl NB, Pullenayegum E, Khong H, Hoch JS, Marshall DA Tags: Am J Manag Care Source Type: research
Fourth ventricular subependymoma presenting as worsening headache.
We describe a 47-year-old man with worsening headaches who was found to have a subependymoma, with a focus on the imaging findings, differential diagnoses, pathology, and treatment. PMID: 23382616 [PubMed]
Source: Baylor University Medical Center Proceedings - January 1, 2013 Category: Universities & Medical Training Authors: Saad AF, Bidiwala SB, Layton KF, Snipes GJ, Opatowsky MJ Tags: Proc (Bayl Univ Med Cent) Source Type: research
Quantitative vascular pathology and phenotyping familial and sporadic cerebral small vessel diseases
Abstract We quantified vascular changes in the frontal lobe and basal ganglia of four inherited small vessel diseases (SVDs) including cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), pontine autosomal dominant microangiopathy and leukoecephalopathy (PADMAL), hereditary multi‐infarct dementia of Swedish type (Swedish hMID) and hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS). Vascular pathology was most severe in CADASIL, and varied with marginally greater severity in the basal ganglia compared to the frontal lobe. The overall sclerotic inde...
Source: Brain Pathology - January 1, 2013 Category: Neurology Authors: L J L Craggs, C Hagel, G Kuhlenbaeumer, A Borjesson‐Hanson, O Andersen, M Viitanen, H Kalimo, C A McLean, J Y Slade, R A Hall, A E Oakley, Y Yamamoto, V Deramecourt, R N Kalaria Tags: Research Article Source Type: research
Pituitary adenomas: Surgery and radiotherapy in the age of molecular diagnostics and pathology
Pituitary adenomas form a common but complex set of neoplasms that frequently appear in clinical practice. Radiologic series and autopsy studies drawn together by formal meta-analysis show that 1 in 7 people harbors a pituitary tumor. However, as adenomas with clinical effect appear in the general population in 1 out of 1000 people, approximately 300,000 people in the United States have (or have had) such a tumor at present, and they are relatively common in oncology practice.
Source: Current Problems in Cancer - January 1, 2013 Category: Cancer & Oncology Authors: Ian E. McCutcheon Source Type: research
OPTIMIZING A PROTOCOL FOR 1H‐MAGNETIC RESONANCE SPECTROSCOPY OF THE CANINE BRAIN AT 3T
This study was performed to develop an MR spectroscopy protocol for routine use in dogs undergoing MR imaging of the brain. Fifteen canine cadavers were used for protocol development. Technical factors evaluated included use of single‐voxel or multivoxel acquisitions, manual placement of saturation bands, echo time (TE), phase‐ and frequency‐encoding matrix size, radiofrequency coil, and placement of the volume of interest relative to the calvaria. Spectrum quality was found to be best when utilizing a multivoxel acquisition with the volume of interest placed entirely within the brain parenchyma without use of manual...
Source: Veterinary Radiology and Ultrasound - January 1, 2013 Category: Veterinary Research Authors: Christopher P. Ober, Christopher D. Warrington, Daniel A. Feeney, Carl R. Jessen, Susan Steward Tags: Original Investigation Source Type: research
Polymeric nanoparticles‐based topical delivery systems for the treatment of dermatological diseases
Abstract Human skin not only functions as a permeation barrier (mainly because of the stratum corneum layer) but also provides a unique delivery pathway for therapeutic and other active agents. These compounds penetrate via intercellular, intracellular, and transappendageal routes, resulting in topical delivery (into skin strata) and transdermal delivery (to subcutaneous tissues and into the systemic circulation). Passive and active permeation enhancement methods have been widely applied to increase the cutaneous penetration. The pathology, pathogenesis, and topical treatment approaches of dermatological diseases, such as ...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - January 1, 2013 Category: Nanotechnology Authors: Zheng Zhang, Pei‐Chin Tsai, Tannaz Ramezanli, Bozena B. Michniak‐Kohn Tags: Advanced Review Source Type: research
A placebo‐controlled pilot study of the novel opioid receptor antagonist ALKS‐33 in binge eating disorder
Discussion:In this preliminary proof‐of‐concept study in BED, ALKS‐33 did not separate from placebo. Although a failed trial cannot be excluded, the finding is consistent with earlier observations in bulimia nervosa with other opioid antagonists and suggests ALKS‐33, at least when administered daily for 6 weeks, may not be efficacious for BED. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)
Source: International Journal of Eating Disorders - January 1, 2013 Category: Eating Disorders and Weight Management Authors: Susan L. McElroy, Anna I. Guerdjikova, Thomas J. Blom, Scott J. Crow, Asli Memisoglu, Bernard L. Silverman, Elliot W. Ehrich Tags: Empirical Article Source Type: research
Focal and segmental glomerulosclerosis in renal allograft recipients: A clinico-pathologic study of 37 cases.
Abstract Focal and segmental glomerulosclerosis (FSGS) in renal allografts may occur as a recurrence of primary FSGS, as a de novo phenomenon or as a complication of calcineurin inhibitor toxicity. There are very few studies in the literature describing the clinico-pathologic characteristics of FSGS in renal allografts. To the best of our knowledge, no such study exists from the Indian subcontinent. Thirty-seven cases showing FSGS, of 426 transplant biopsies performed over a 4-year period (2006-2009), were included in this study. The pre- and post-transplant clinical data were noted. FSGS was classified as per the ...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2013 Category: Urology & Nephrology Authors: Gupta R, Sharma A, Mahanta PJ, Agarwal SK, Dinda AK Tags: Saudi J Kidney Dis Transpl Source Type: research
Comparison of the diagnostic performance of response evaluation criteria in solid tumor 1.0 with response evaluation criteria in solid tumor 1.1 on MRI in advanced breast cancer response evaluation to neoadjuvant chemotherapy.
CONCLUSION: RECIST 1.1 showed better diagnostic performance than RECIST 1.0, although there was no statistically significant difference between the two. PMID: 23323026 [PubMed - in process]
Source: Korean J Radiol - January 1, 2013 Category: Radiology Authors: Jeh SK, Kim SH, Kang BJ Tags: Korean J Radiol Source Type: research
Mesenteric Vascular Occlusion: Comparison of Ancillary CT Findings between Arterial and Venous Occlusions and Independent CT Findings Suggesting Life-Threatening Events.
CONCLUSION: The ancillary CT findings occur with different frequencies in SMAT and SMVT. However, the independent findings indicating life-threatening mesenteric occlusion are diminished bowel wall enhancement and paralytic ileus. PMID: 23323029 [PubMed - in process]
Source: Korean J Radiol - January 1, 2013 Category: Radiology Authors: Wong YC, Wu CH, Wang LJ, Chen HW, Lin BC, Huang CC Tags: Korean J Radiol Source Type: research
Clinical Neuropathology 1-2013 - happy start into the year 2013.
PMID: 23324354 [PubMed - in process]
Source: Clinical Neuropathology - January 1, 2013 Category: Pathology Authors: Hainfellner JA Tags: Clin Neuropathol Source Type: research
Clinical neuropathology practice guide 1-2013: Molecular subtyping of glioblastoma: ready for clinical use?
Abstract Recently, integrated genomewide analyses have revealed several glioblastoma (GB) subtypes, which differ in terms of key pathogenetic pathways and point to different cells of origin. Even though the proneural and mesenchymal GB signatures evolved as most robust, there is no consensus on the exact number of subtypes and defining criteria. Moreover, important issues concerning within-tumor heterogeneity and class-switching upon recurrence remain to be addressed. Early evidence indicates an association of different GB subtypes with patient outcome and response to therapy, which argues for the implementation of...
Source: Clinical Neuropathology - January 1, 2013 Category: Pathology Authors: Woehrer A, Marosi C, Widhalm G, Oberndorfer S, Pichler J, Hainfellner JA Tags: Clin Neuropathol Source Type: research
Non‐linear optical microscopy of kidney tumours
Abstract The unregulated cancer cell growth leads to strong alterations in morphology and composition of the tissue. The combination of coherent anti‐Stokes Raman scattering, two‐photon excited fluorescence and second harmonic generation enables a high resolution imaging with strong information on tissue composition and can then provide useful information for tumour diagnosis. Here we present the potential of multimodal non‐linear microscopy for imaging of renal tumours. Using cryosections of human oncocytoma and carcinoma, the method gave a detailed insight in cancer morphology and composition, enabling to discern b...
Source: Journal of Biophotonics - January 1, 2013 Category: Physics Authors: Roberta Galli, Valdas Sablinskas, Darius Dasevicius, Arvydas Laurinavicius, Feliksas Jankevicius, Edmund Koch, Gerald Steiner Tags: Letter Source Type: research
[Metabolic therapy at the edge between human hosts and gut microbes].
Abstract Personalized medicine is becoming day-after-day more urgent taking into account the great diversity characterizing patients affected by a given pathology, especially metabolic diseases. In fact, antidiabetic/obesity treatments have shown a reduced or no effect at all in some patients, representing a major challenge physicians have to face worldwide. Therefore, efforts have to be put to identify individual factors affecting our susceptibility towards a given medication. In that regard, gut microbiota may stand for the missing piece of the metabolic puzzle regulating host response, since its role in the indu...
Source: Annales Pharmaceutiques Francaises - January 1, 2013 Category: Drugs & Pharmacology Authors: Blasco-Baque V, Serino M, Burcelin R Tags: Ann Pharm Fr Source Type: research
Cytologic and cystoscopic predictors of recurrence and progression in patients with low‐grade urothelial carcinoma
CONCLUSIONS:Cystoscopic findings, such as the presence of multiple lesions, together with concurrent positive or suspicious urine cytology, were associated with recurrence or progression of LGUC. These findings may help to identify high‐risk patients. Cancer (Cancer Cytopathol) 2012;. © 2012 American Cancer Society.
Source: Cancer Cytopathology - January 1, 2013 Category: Pathology Authors: Julie Jackson, Güliz A. Barkan, Umesh Kapur, Eva M. Wojcik Tags: Original Article Source Type: research
Impaired cytoplasmic‐nuclear transport of hypoxia‐inducible factor‐1α in amyotrophic lateral sclerosis
Abstract We investigated the mechanisms underlying abnormal vascular endothelial growth factor (VEGF) production in amyotrophic lateral sclerosis (ALS). We immunohistochemically studied VEGF, its receptors VEGFR1 and 2, and hypoxia‐inducible factor‐1α (HIF‐1α) in autopsied ALS spinal cords. We also chronologically assessed expression of HIF‐1α, karyopherin β1, karyopherin β‐cargo protein complex inhibitors, and nuclear pore complex proteins in G93A mutant superoxide dismutase 1 (mSOD1) transgenic mice at presymptomatic, symptomatic and end stages. In ALS patients, compared with controls, HIF‐1α immunoreac...
Source: Brain Pathology - January 1, 2013 Category: Neurology Authors: Yuko Nagara, Takahisa Tateishi, Ryo Yamasaki, Shintaro Hayashi, Mami Kawamura, Hitoshi Kikuchi, Kyoko Motomura Iinuma, Masahito Tanaka, Toru Iwaki, Takuya Matsushita, Yasumasa Ohyagi, Jun‐ichi Kira Tags: Research Article Source Type: research
The Tetrad BMI, Leptin, Leptin/Adiponectin (L/A) Ratio and CA 15-3 are Reliable Biomarkers of Breast Cancer.
CONCLUSION: When the four variables were analysed together, a sensitivity of 83.3%, specificity of 80%, positive predictive value of 83.3% and negative predictive value of 80% were obtained. Results indicate that using the 75th percentile set points for BMI, leptin, L/A ratio and CA 15-3 together could offer a reliable approach to determine which women are at high risk for developing breast cancer. PMID: 23292756 [PubMed - in process]
Source: Clinical Breast Cancer - January 1, 2013 Category: Cancer & Oncology Authors: Santillán-Benítez JG, Mendieta-Zerón H, Gómez-Oliván LM, Torres-Juárez JJ, González-Bañales JM, Hernández-Peña LV, Ordóñez-Quiroz A Tags: J Clin Lab Anal Source Type: research
Can a gene‐expression classifier with high negative predictive value solve the indeterminate thyroid fine‐needle aspiration dilemma?
The recent study by Alexander et al validates the effectiveness of the Afirma test, and suggests a potential ancillary role for this unique test when appropriately applied in the evaluation of thyroid nodules classified by fine‐needle aspiration as indeterminate. Cancer (Cancer Cytopathol) 2013. © 2013 American Cancer Society.
Source: Cancer Cytopathology - January 1, 2013 Category: Pathology Authors: William C. Faquin Tags: Commentary Source Type: research
Development of Orthotopic Pancreatic Tumor Mouse Models
Genetically engineered mouse models of pancreatic cancer that recapitulate human pancreatic tumorigenesis have been established. However, the cost associated with generating and housing these mice can be prohibitive. Tumor latency and progression to invasive diseases in these models are also highly variable. Xenograft mouse models of human pancreatic cancer including heterotopic and orthotopic have been widely used in preclinical studies for their comparatively low cost and rapid, predictable tumor growth. Of the two, orthotopic tumor mouse models are preferred because they offer tissue site-specific pathology, allow ...
Source: Springer protocols feed by Cancer Research - January 1, 2013 Category: Cancer & Oncology Source Type: news
Surgical management of craniopharyngioma with third ventricle involvement.
Abstract Craniopharyngiomas are notorious for their ability to invade the hypothalamus and third ventricle. Although several transcranial approaches have been proposed for their treatment, the endonasal route provides direct access to the tumor with no need for cerebral retraction or manipulation of the optic apparatus. After the lesion is debulked, the unique angle of approach achieved with this technique enables the surgeon to perform an extra-capsular dissection and visualize the walls of the third ventricle, the foramina of Monro, and the anterior comissure. Moreover, the enhanced magnification and lighting aff...
Source: Neurosurgical Focus - January 1, 2013 Category: Neurosurgery Authors: de Lara D, Ditzel Filho LF, Muto J, Otto BA, Carrau RL, Prevedello DM, M D Tags: Neurosurg Focus Source Type: research
MicroRNAs in the regulation of immune response against infections.
Abstract Innate immunity is considered to provide the initial defense against infections by viruses, bacteria, fungi, and protozoa. Detection of the signature molecules of invading pathogens by front-line defense cells via various germline-encoded pattern recognition receptors (PRRs) is needed to activate intracellular signaling cascades that lead to transcriptional expression of inflammatory mediators to coordinate the elimination of pathogens and infected cells. To maintain a fine balance between protective immunity and inflammatory pathology upon infection, the innate signaling pathways in the host need to be ti...
Source: J Zhejiang Univ Sci ... - January 1, 2013 Category: Science Authors: Zhang Y, Li YK Tags: J Zhejiang Univ Sci B Source Type: research
Importance of Vertical Pathology of Debulking Specimens During Mohs Micrographic Surgery for Lentigo Maligna and Melanoma in Situ
ConclusionWhen performing MMS for LM or MIS, it is appropriate and necessary to send the central debulking specimen for permanent histology for accurate tumor staging.
Source: Dermatologic Surgery - January 1, 2013 Category: Dermatology Authors: Luciano J. Iorizzo, Isaac Chocron, Wilfred Lumbang, Thomas Stasko Tags: Original Article Source Type: research
Contemporaneous comparison of open vs minimally‐invasive radical prostatectomy for high‐risk prostate cancer
Conclusions At an experienced centre, MIRP is comparable to open radical prostatectomy for HRPC with respect to surgical margin status and biochemical recurrence.
Source: BJU International - January 1, 2013 Category: Urology & Nephrology Authors: Phillip M. Pierorazio, Jeffrey K. Mullins, John B. Eifler, Kipp Voth, Elias S. Hyams, Misop Han, Christian P. Pavlovich, Trinity J. Bivalacqua, Alan W. Partin, Mohamad E. Allaf, Edward M. Schaeffer Tags: Urological Oncology Source Type: research
Mechanisms of diabetic complications.
Abstract It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required, but also for its major complications, affecting both small and large blood vessels. These complications occur in the majority of individuals with both type 1 and type 2 diabetes. Among the most prevalent microvascular complications are kidney disease, blindness, and amputations, with current therapies only slowing disease progression. Impaired kidney function, exhibited as a reduced glomerular filtration rate, is also a major risk factor for macrovascular complications, such as heart attacks and stroke...
Source: Physiological Reviews - January 1, 2013 Category: Physiology Authors: Forbes JM, Cooper ME Tags: Physiol Rev Source Type: research
Diagnosis of Liver Disease in Domestic Ferrets (Mustela Putorius)
Liver disease in ferrets is often subclinical and underdiagnosed. Clinical pathology and diagnostic imaging are needed to guide clinicians but definite diagnosis is based on histopathologic lesions. Inflammatory digestive conditions can lead to ascending tract infection and hepatobiliary inflammation. Ferrets have a specific sensitivity to hepatic lipidosis. Incidence of hepatic neoplasia is high in ferrets. After a summary of anatomy and physiology of the ferret liver, hepatic diseases known in ferret species are reviewed with their subsequent diagnostic procedures.
Source: Veterinary Clinics of North America: Exotic Animal Practice - January 1, 2013 Category: Veterinary Research Authors: Minh Huynh, Flora Laloi Source Type: research
Encephalitis with infiltration by CD8+ Lymphocytes in HIV Patients receiving Combination Antiretroviral Treatment
We report the neuropathological findings in 10 HIV‐infected patients treated by combination anti‐retroviral therapy who developed subacute encephalopathy of rapidly progressive onset. Brain biopsy showed encephalitic lesions variably associated with myelin loss and slight axonal damage. There was inconstant, weak expression of HIV protein p24; tests for other pathogens were negative. The most striking feature was diffuse, perivascular and intraparenchymal infiltration by CD8+, T lymphocytes. Six patients improved following treatment. Four had an unfavourable outcome and died within a year. Postmortem in one case confir...
Source: Brain Pathology - January 1, 2013 Category: Neurology Authors: Françoise Gray, François Xavier Lescure, Homa Adle‐Biassette, François Marc Polivka, Sébastien Gallien, Gilles Pialoux, Antoine Moulignier Tags: Research Article Source Type: research
Decitabine represses translocated MYC oncogene in Burkitt lymphoma
Abstract Burkitt lymphoma (BL) is caused by translocation of the MYC gene to an immunoglobulin locus resulting in its constitutive expression depending on the activity of the immunoglobulin (Ig) enhancer elements. Treatment of BL cell lines with epigenetic modifiers is known to repress B‐cell specific genes and to up‐regulate B‐cell‐inappropriate genes including the transcription repressor ID2 expression. We found that DNA methyltransferase inhibitor decitabine/5‐aza‐2‐deoxycytidine (5‐aza‐dC) represses the MYC oncogene on RNA and protein levels by inducing ID2. Down‐regulation of MYC was associated wit...
Source: The Journal of Pathology - January 1, 2013 Category: Pathology Authors: Hanfeng Guan, Linka Xie, Kay Klapproth, Clarissa D. Weitzer, Thomas Wirth, Alexey Ushmorov Tags: Original Paper Source Type: research
Evaluation of GLUT‐1 in the granular cell tumour and congenital granular cell epulis
ConclusionsNeither granular cell tumour nor congenital granular cell epulis is directly related to perineurial cells.
Source: Journal of Oral Pathology and Medicine - January 1, 2013 Category: Pathology Authors: Giovanna Ribeiro Souto, Patrícia Carlos Caldeira, Aline Cristina Batista Rodrigues Johann, Helenicede Andrade Marigo, Suzana Cantanhede Orsini Machadode Souza, Ricardo Alves Mesquita Tags: Original Article Source Type: research
Endoscopic ultrasound in pediatric patients
Abstract: Endoscopic ultrasound is becoming increasingly popular in the practice of pediatric gastroenterology. It is widely used in adults to both diagnose and treat gastrointestinal tract pathology, including, but not limited to, congenital abnormalities, submucosal lesions, cholelithiasis, malignancies, autoimmune diseases (ie, Crohn's disease, ulcerative colitis), pancreaticobiliary disease, and eosinophilic esophagitis. Experience with this technology in pediatric population is still limited but is rapidly growing. Certain aspects of pediatric cases require special consideration, especially differences in size of ana...
Source: Techniques in Gastrointestinal Endoscopy - January 1, 2013 Category: Gastroenterology Authors: Nikhil Banerjee, Douglas G. Adler Source Type: research
Transgender voice and communication treatment: a retrospective chart review of 25 cases.
CONCLUSIONS & IMPLICATIONS: Treatment goals for clients included in this study were consistent with those goals most often recommended in the research literature regarding voice and communication treatment for transgender clients. Voice and communication treatment resulted in gains in areas important to listeners' perception of gender. Further research is warranted to determine efficacy of specific treatment protocols and potentially influential factors such as initial voice and communication status. PMID: 23317384 [PubMed - in process]
Source: International Journal of Language and Communication Disorders - January 1, 2013 Category: Speech Therapy Authors: Hancock AB, Garabedian LM Tags: Int J Lang Commun Disord Source Type: research
Speech and language therapy/pathology: perspectives on a gendered profession.
CONCLUSIONS & IMPLICATIONS: Gender imbalance in SLT needs to be researched further in order to help address inequalities, re-evaluate professional practices and develop service delivery in the profession. This area also needs to be researched via analysis that goes beyond gender distribution in numerical terms to consider the complex perceptions or discourses around gender and work. Cross-disciplinary and comparative perspectives in future research would also be fruitful. PMID: 23317387 [PubMed - in process]
Source: International Journal of Language and Communication Disorders - January 1, 2013 Category: Speech Therapy Authors: Litosseliti L, Leadbeater C Tags: Int J Lang Commun Disord Source Type: research
Benefits of the fiber optic versus the electret microphone in voice amplification.
CONCLUSIONS & IMPLICATIONS: Patients with neurological and/or respiratory-based voice problems may more confidently and frequently use the fiber optic microphone to communicate, socialize and participate in occupational activities more easily. Speech-language pathologists may more confidently use or recommend the fiber optic microphone with amplification systems. PMID: 23317389 [PubMed - in process]
Source: International Journal of Language and Communication Disorders - January 1, 2013 Category: Speech Therapy Authors: Kyriakou K, Fisher HR Tags: Int J Lang Commun Disord Source Type: research
Clinical Examination of the Rotator Cuff
Rotator cuff tears are the leading cause of shoulder pain and shoulder-related disability and account for 4.5 million physician visits in the United States annually. A careful history and structured physical examination are often sufficient for diagnosing rotator cuff disorders. We are not aware of a clinical review article that presents a structured physical examination protocol of the rotator cuff for the interested clinician. To fill this void, we present a physical examination protocol developed on the basis of review of prior literature and our clinical experience from dedicated shoulder practices. Our protocol includ...
Source: PM and R - January 1, 2013 Category: Rehabilitation Authors: Nitin B. Jain, Reg B. Wilcox, Jeffrey N. Katz, Laurence D. Higgins Tags: Clinical Review: Teaching Rounds Source Type: research
Interview: Immunogenicity: the elephant in the room for regenerative medicine?
Abstract Paul Fairchild speaks to Alexandra Hemsley, Assistant Commissioning Editor Paul Fairchild began his research career in Oxford, UK, where he studied for a doctorate within the Nuffield Department of Surgical Sciences, focusing on the immune response to organ allografts. After spending 5 years as a postdoctoral fellow investigating the etiology of autoimmune disease in the Department of Pathology, University of Cambridge, UK, he returned to Oxford, where he is currently a University Lecturer in Preclinical Medicine within the Sir William Dunn School of Pathology and a Fellow of Trinity College. In 2008, Fai...
Source: Regenerative Medicine - January 1, 2013 Category: Genetics & Stem Cells Authors: Fairchild P Tags: Regen Med Source Type: research
LSHSS Is Critical to the Practice of School Speech-Language Pathology.
PMID: 23305939 [PubMed - in process]
Source: Language, Speech, and Hearing Services in Schools - January 1, 2013 Category: Speech Therapy Authors: Schuele CM Tags: Lang Speech Hear Serv Sch Source Type: research
Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?
Abstract Pleomorphic fibromas represent dome‐shaped or polypoid cutaneous lesions characterized by a paucicellular and densely fibrotic background punctuated by scattered atypical to pleomorphic spindle and multinucleated giant cells. Some of these tumors will have incorporated adipose tissue, though these adipocytic areas lack distinct cytologic atypia and may represent entrapped normal periadnexal or subcutaneous adipose tissue. Nonetheless, due to the similarity of some of the morphologic features of pleomorphic fibroma with cutaneous atypical lipomatous tumor, diagnostic confusion can ensue. The potential diagnosti...
Source: Journal of Cutaneous Pathology - January 1, 2013 Category: Pathology Authors: Tariq Al‐Zaid, Wei‐Lien Wang, Dolores Lopez‐Terrada, Dina Lev, Jason L. Hornick, A. Hafeez Diwan, Christopher D. M. Fletcher, Alexander J. Lazar Tags: Original Article Source Type: research
Monoclonal plasma cell proliferation, associated with crystal storing histiocytosis in a background of plasmacytoid dendritic cell tumour (PDCT) in a patient with stable chronic myelomonocytic leukaemia (CMML)
We describe a case of plasmacytoid dendritic cell tumours (PDCTs) in a 72 year‐old female with a stable chronic myelomonocytic leukaemia (CMML) of 5 years duration. A recent bone marrow aspirate and trephine showed CMML with 5% blasts without evidence of blast transformation or involvement by plasma cell myeloma. © 2013 Blackwell Publishing Ltd
Source: Histopathology - January 1, 2013 Category: Pathology Authors: Ibrahim M Zardawi, Ferenc Szabo Tags: Correspondence Source Type: research
The anti‐inflammatory effect of cyclooxygenase inhibitors in fibroblast‐like synoviocytes from the human temporomandibular joint results from the suppression of PGE2 production
ConclusionThe COX inhibitors indomethacin and celecoxib reduce the expression of inflammatory factors, such as COX‐2 and IL‐6, in FLS from the TMJ via suppression of PGE2 production. EP2 and EP4 were the main receptors for PGE2 present in the FLS. The approach used in this study may be useful for revealing how drugs such as NSAIDs affect the cellular functions of FLS from the TMJ.
Source: Journal of Oral Pathology and Medicine - January 1, 2013 Category: Pathology Authors: Mutsumi Kawashima, Naomi Ogura, Miwa Akutsu, Ko Ito, Toshirou Kondoh Tags: Original Article Source Type: research
Onychotillomania: Clinicopathologic Correlations
Abstract Onychotillomania represents an unusual dermatosis affecting the nail unit. The term refers to ‘neurotic picking at a nail until it is permanently altered’. It can be difficult for dermatologists to diagnose, as typically patients will deny the self‐destructive behavior and the clinical features may mimic other inflammatory conditions affecting the nail unit. Aside from the difficulty in establishing the diagnosis clinically, the histopathologic features of onychotillomania are non‐specific. With this limited knowledge, dermatopathologists could have difficulty correlating the clinical and histopathologic f...
Source: Journal of Cutaneous Pathology - January 1, 2013 Category: Pathology Authors: Jennifer M. Reese, Kristin D. Hudacek, Adam I. Rubin Tags: Case Report Source Type: research
Expression of Olfactomedin 4 and Claudin‐18 in Serrated Neoplasia of the Colorectum: A Characteristic Pattern is Associated with Sessile Serrated Lesion
ConclusionsReduced expression of olfactomedin 4 and ectopic expression of claudin‐18 might be useful markers in the differential diagnosis of serrated polyps.© 2013 Blackwell Publishing Ltd
Source: Histopathology - January 1, 2013 Category: Pathology Authors: Kazuhiro Sentani, Naoya Sakamoto, Fumio Shimamoto, Katsuhiro Anami, Naohide Oue, Wataru Yasui Tags: Original Article Source Type: research
Role of the faecolith in modern-day appendicitis.
CONCLUSIONS: Faecolith prevalence is too low to consider the faecolith the most common cause of non-perforated appendicitis. Faecoliths are more prevalent in paediatric appendicitis than in adult appendicitis. Preoperative CT is an unreliable predictor of faecoliths in pathology specimens. PMID: 23317728 [PubMed - in process]
Source: Annals of the Royal College of Surgeons of England - January 1, 2013 Category: Surgery Authors: Singh JP, Mariadason JG Tags: Ann R Coll Surg Engl Source Type: research
Identification of eight candidate target genes of the recurrent 3p12‐p14 loss in cervical cancer by integrative genomic profiling
Abstract The pathogenetic role, including its target genes, of recurrent 3p12‐p14 loss in cervical cancer has remains unclear. To determine the onset of the event during carcinogenesis, we used microarray techniques and found that the loss was the most frequent 3p event, occurring in 61% of 92 invasive carcinomas, in only 2% of 43 high‐grade intraepithelial lesions (CIN2/3), and in 33% of 6 CIN3 lesions adjacent to invasive carcinomas, suggesting a role in acquisition of invasiveness or early during the invasive phase. We performed an integrative DNA copy number and expression analysis of 77 invasive carcinomas, where ...
Source: The Journal of Pathology - January 1, 2013 Category: Pathology Authors: Malin Lando, Saskia M. Wilting, Kristin Snipstad, Trevor Clancy, Mariska Bierkens, Eva‐Katrine Aarnes, Marit Holden, Trond Stokke, Kolbein Sundfør, Ruth Holm, Gunnar B. Kristensen, Renske D.M. Steenbergen, Heidi Lyng Tags: Original Article Source Type: research