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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Epidemiology and susceptibilities of methicillin-resistant Staphylococcus aureus in Northeastern Ohio.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report sheds further light on the rapid spread of MRSA across Northeastern Ohio, stressing the need for better education in preventive measures and infection control at the level of community and health care settings. PMID: 19846806 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 24, 2009 Category: Pathology Authors: Delorme T, Rose S, Senita J, Callahan C, Nasr P Tags: Am J Clin Pathol Source Type: journals

Early Detection of Breast Cancer: New Biomarker Tests on the Horizon?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Molecular Diagnosis)
Source: Molecular Diagnosis - November 21, 2009 Category: Pathology Authors: Jotwani, Aparna C.Gralow, Julie R. Tags: Review Articles Source Type: journals

Newspath July, 2009 - Update on West Nile VirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
West Nile Virus is an arthropod-born Flavivirus that is the most common cause of viral meningoencephalitis in North America. The transmission of West Nile Virus to humans is due primarily to inoculation by an infected mosquito, with peak incidence of transmission taking place between July and October. (Source: NewsPath - Pathology News for the Medical Community)
Source: NewsPath - Pathology News for the Medical Community - July 1, 2009 Category: Pathology Source Type: news

Correlation between morphology and human telomerase gene amplification in bronchial brushing cells for the diagnosis of lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to investigate the frequency of amplification of the human telomerase gene (TERC), as measured by fluorescence in situ hybridization (FISH), in routine liquid-based cytological preparations from bronchial brushing specimens, and to assess the associations between TERC amplification, cytological diagnosis, and cytological morphology, in order to obtain further insight into these associations. Bronchial brushings from 102 patients with lung carcinoma (52 squamous-cell carcinomas, 22 adenocarcinomas, 28 small cell lung carcinomas) and 40 patients with nonmalignant disease were used. Amplification of ...
Source: Diagnostic Cytopathology - October 30, 2009 Category: Pathology Authors: Yi-Bo Fan, Lin Ye, Tian-Yu Wang, Guang-Ping Wu Source Type: journals

Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsivenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we have demonstrated for the first time an important role for seladin-1 in the biology of TGCTs and provided new insights into cisplatin responsiveness of these tumours. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 19, 2009 Category: Pathology Authors: Francesca Nuti, Paola Luciani, Eliana Marinari, Edit Erdei, Mihaly Bak, Cristiana Deledda, Fabiana Rosati, Benedetta Mazzinghi, Giovanna Danza, Hans Stoop, Leendert HJ Looijenga, Alessandro Peri, Mario Serio, Csilla Krausz Source Type: journals

Genomic instability and the selection of treatments for cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A critical link exists between DNA mutation and chromosomal rearrangements (genomic instability) and cancer development. This genomic instability can manifest itself as small changes at the nucleotide level or as gross chromosomal alterations. Mutations in the genes that encode DNA damage response proteins are responsible for a variety of genomic instability syndromes including hereditary non-polyposis colorectal carcinoma, Bloom's syndrome, ataxia-telangiectasia, BRCA-associated breast and ovarian cancers and Fanconi anaemia. Similarly, epigenetic silencing of genes associated with the maintenance of genomic stability hav...
Source: The Journal of Pathology - November 3, 2009 Category: Pathology Authors: Sarah A Martin, Madeleine Hewish, Christopher J Lord, Alan Ashworth Source Type: journals

Clinical performance of JAK2 V617F mutation detection assays in a molecular diagnostics laboratory: evaluation of screening and quantitation methods.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The presence of the JAK2 V617F mutation is now part of clinical diagnostic algorithms, and JAK2 status is routinely assessed when BCR/ABL- chronic myeloproliferative neoplasms (MPNs) are suspected. The aim of this study was to evaluate performance of 3 screening and 1 quantitative method for JAK2 V617F detection. For the study, 43 samples (27 bone marrow aspirates and 16 peripheral blood samples) were selected. The screening assays were the JAK2 Activating Mutation Assay (InVivoScribe, San Diego, CA), JAK2 MutaScreen kit (Ipsogen, Luminy Biotech, Marseille, France), and a home-brew melting curve analysis method. Ipsoge...
Source: American Journal of Clinical Pathology - October 24, 2009 Category: Pathology Authors: Cankovic M, Whiteley L, Hawley RC, Zarbo RJ, Chitale D Tags: Am J Clin Pathol Source Type: journals

The Bethesda System For Reporting Thyroid Cytopathology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To address terminology and other issues related to thyroid fine-needle aspiration (FNA), the National Cancer Institute (NCI) hosted the NCI Thyroid FNA State of the Science Conference. The conclusions regarding terminology and morphologic criteria from the NCI meeting led to the Bethesda Thyroid Atlas Project and form the framework for The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). For clarity of communication, TBSRTC recommends that each report begin with 1 of 6 general diagnostic categories. The project participants hope that the adoption of this flexible framework will facilitate communication amo...
Source: American Journal of Clinical Pathology - October 24, 2009 Category: Pathology Authors: Cibas ES, Ali SZ Tags: Am J Clin Pathol Source Type: journals

The cytological diagnosis of paediatric renal tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fine needle aspiration cytology (FNAC) is used for preoperative diagnosis of paediatric renal tumours, especially in centres where preoperative chemotherapy is advocated in Wilms’ tumour. This review focuses on salient cytological features in specific paediatric renal tumours, the approach to resolving a differential diagnosis and the role of ancillary methods in diagnosis of paediatric renal tumours. Crucial differential diagnoses include distinguishing: Wilms’ tumour from benign tumours in the kidney like multicystic nephroma or congenital mesoblastic nephroma; aggressive non-Wilms’ tumours of kidney li...
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Shet, T, Viswanathan, S Tags: Cytogenetics, Immunology (including allergy), Urological cancer, Paediatric oncology, Clinical diagnostic tests My approach Source Type: journals

Histiocytic sarcoma with interdigitating dendritic cell differentiation: A case report with fine needle aspiration cytology and review of literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A hybrid histiocytic sarcoma-interdigitating dendritic cell sarcoma was found in a small perinephric lymph node of an asymptomatic 80-year-old man, who presented a year ago with two small foci of lung metastasis found during routine chest X-ray. Fine needle aspiration cytology demonstrated interconnecting long and thin cell processes radiating from dendrite-like neoplastic cells with oval, enlongated, reniform, and irregular nuclei with vesicular chromatin and distinct nucleoli. Histology showed spindled epitheliod and histiocytic cells with abundant, slightly eosinophilic cytoplasm with indistinct cell borders and forming...
Source: Diagnostic Cytopathology - October 19, 2009 Category: Pathology Authors: Grace C. H. Yang, Carrie E. Besanceney, Wayne Tam Source Type: journals

Metastatic potential of an aneurysmal bone cystEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa. Recently, the hypothesis that ABCs are lesions reactive to local hemodynamics has been challenged after the discovery of specific recurrent chromosomal abnormalities. Multiple cases of malignant transformation of ABC into (osteo)sarcoma have been described, as well as a number of cases of telangiectatic osteosarcoma which had been misdiagnosed as ABC. We herewith document a case of a pelvic ABC metastatic to the lung, liver, and kidneys. Diagnosis was confirmed by the presence of...
Source: Virchows Archiv - October 16, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Histological heterogeneity of Ewing’s sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical supportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the diagnosis of atypical ES is a challenge for the pathologist and needs support from molecular techniques to perform an optimal differential diagnosis with other small round cell tumors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00428-009-0842-7Authors Antonio Llombart-Bosch, University of Valencia Department of Pathology Ave. Blasco Ibañez, 17 46010 Valencia SpainIsidro Machado, University of Valencia Department of Pathology Ave. Blasco Ibañez, 17 46010 Valencia SpainSamuel Navarro, University of Valencia Department of Pathology Ave. Blasco Ibañez, 17 46010 Valencia SpainF...
Source: Virchows Archiv - October 20, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

P38 mitogen activated protein kinase expression and regulation by interleukin-4 in human B cell non-Hodgkin lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, there is constitutive expression and activation of p38 MAPK in a large number of B-lymphoma-derived cell lines and primary lymphoma tissues, supportive of its role in lymphomagenesis. The differential IL-4 regulation of p38 MAPK expression in cell lines derived from DLBCL may relate to the cellular origin of these neoplasms. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12308-009-0049-5Authors Hu Ding, University of Utah Health Sciences Center Salt Lake City UT USAAli M. Gabali, University of Michigan Department of Pathology 4061 BSRB, 109 Zina Pitcher Place Ann Arbor MI 48109 USAS...
Source: Journal of Hematopathology - October 21, 2009 Category: Pathology Tags: Journal of Hematopathology Source Type: journals

Primary effusion lymphoma involving three body cavitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe herein a case of PEL affecting three body cavity sites in an immunocompetent patient. A 69-year-old HIV-negative man presented with upper gastrointestinal bleeding and ascites. An examination of the fluid by cytology showed large atypical lymphocytes with abundant basophilic cytoplasm, either central or eccentric nuclei having irregular outlines, and multiple prominent nucleoli. The neoplastic cells showed positive staining for CD45, CD3, HHV8 latent nuclear antigen (LNA), and Epstein-Barr virus-encoded RNA. A diagnosis of PEL was rendered. Despite chemotherapy and valganciclovir, the disease progressed to invo...
Source: CytoJournal - October 10, 2009 Category: Pathology Authors: Brimo Fadi, Popradi Gizelle, Michel Rene P, Auger Manon Source Type: journals

Pulmonary carcinosarcoma masquerading as a cryptic disseminated malignancy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case which presented with unusual clinical features and proved cryptic until death. At autopsy, it was a stage IV lung malignancy and histopathology revealed a carcinosarcoma comprising an adenocarcinoma and an osteosarcoma with metastasis to the heart, lymph nodes, and both adrenals. To our knowledge, this is the first case of this subtype with metastasis to the heart. The present case had an unusual clinical presentation and its elusive nature towards diagnosis despite dissemination is noteworthy and unique in the literature. PMID: 19805960 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Kaur A, Falleiro JJ, Ghosh AK, Mani NS Tags: Indian J Pathol Microbiol Source Type: journals

HER-2/neu expression in lesions of uterine cervix: is it reliable and consistent?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted to evaluate the expression of HER-2/neu oncogene in the lesions of the uterine cervix and to determine its correlation with histological type of malignancy, grade and clinical stage of presentation. One hundred cervical specimens were included in this study. These comprised cases with diagnosis of benign epithelial lesions, squamous cell carcinoma, adenocarcinoma, carcinoma cervix with glandular differentiation and cervical intraepithelial neoplasia. HER-2/neu immunostaining was performed by streptovidin-biotin peroxidase method. Higher expression of HER-2/neu was noted in malignant lesions as comp...
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Gupta N, Singh S, Marwah N, Kumar S, Chabra S, Sen R Tags: Indian J Pathol Microbiol Source Type: journals

Aberrant expression of p27Kip1-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the expressions of p27Kip1-interacting proteins, i.e., p27Kip1, Skp2, Cks1, cyclin A, cyclin E, and the Ki-67 labeling index (LI), were analyzed in 25 CCAFs (11 benign and 14 borderline) and 15 CCAF-associated CCAs, and compared with the expression status of each protein in the 23 previously studied endometriosis-associated CCAs. Although aberrant expression of all p27Kip1-interacting proteins was more frequent in the CCAF-associated CCAs than in the benign CCAFs, statistical significance was found only for Cks1 overexpression. The frequencies of p27Kip1 downregulation and overexpression of Skp2 and cycli...
Source: Virchows Archiv - October 23, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

New time-dependent approach to analyse the prognostic significance of immunohistochemical biomarkers in colon cancer and diffuse large B-cell lymphomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Time-dependent ROC curve analysis is a novel tool for identifying potential immunohistochemical prognostic markers across varying follow-up times. Use of this tool could facilitate the identification of high-risk patients not only with colon cancer and DLBCL but with a range of other tumour types. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 27, 2009 Category: Pathology Authors: Adams, H, Tzankov, A, Lugli, A, Zlobec, I Tags: Immunology (including allergy), Breast cancer, Colon cancer Original articles Source Type: journals

Flow cytometric immunophenotyping and minimal residual disease analysis in multiple myeloma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Presence of normal plasma cells (PCs), hemodilution of bone marrow aspirate, and changes in the immunophenotype are important considerations in minimal residual disease (MRD) assessment in multiple myeloma (MM). We evaluated 124 subjects-107 with MM, 11 with Hodgkin lymphoma, and 6 allogeneic stem cell transplantation donors-for the immunophenotype of neoplastic, reactive, and normal PCs respectively. Of the patients with MM, 36 were evaluated for MRD and 23 for a change in immunophenotype after chemotherapy. The immunophenotype of normal and reactive PCs was similar and differed from that of neoplastic PCs with respec...
Source: American Journal of Clinical Pathology - October 24, 2009 Category: Pathology Authors: Gupta R, Bhaskar A, Kumar L, Sharma A, Jain P Tags: Am J Clin Pathol Source Type: journals

Is the QuantiFERON-TB blood assay a good replacement for the tuberculin skin test in tuberculosis screening? a pilot study at Berkshire Medical Center.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a pilot study comparing the QFT-GIT and TST results for screening health care workers (HCWs) at Berkshire Medical Center (BMC; Pittsfield, MA), the second hospital in Massachusetts to use QFT-GIT. For the study, 40 BMC HCWs, 20 TST+ and 20 TST-, were screened with the QFT-GIT test. All 20 TST- subjects were also QFT-GIT-, while only 10 of 20 TST+ subjects were QFT-GIT+. The overall agreement between the QFT-GIT and TST results was 75% (kappa = 0.5; 95% confidence interval, 0.268-0.732). The suboptimal agreement was partially due to a higher specificity of QFT-GIT. Confounding factors (eg, bacille Calmette-Gué...
Source: American Journal of Clinical Pathology - October 24, 2009 Category: Pathology Authors: Zhao X, Mazlagic D, Flynn EA, Hernandez H, Abbott CL Tags: Am J Clin Pathol Source Type: journals