Pediatrics Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

Plasma Exchange in Pediatric CNS Inflammatory Demyelination (P02.119)
CONCLUSIONS: We describe our experience with PLEX in children with severe CNS inflammatory demyelination. Side effects necessitating intervention were observed in 25%. Over half of the children in this series regained independent ambulation 3 months after PLEX. Given the retrospective nature and small cohort, prospective studies in larger pediatric cohorts are warranted.Disclosure: Dr. Bigi has received personal compensation for activities with the Swiss Multiple Sclerosis Society, the Bangerter-Rhyner Foundation, and Biogen Dompe. Dr. Banwell has received personal compensation for activities with Merck Serono, Biogen Idec...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Bigi, S., Banwell, B., Yeh, E. A. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Treatment and Disability Trends in a Predominantly Hispanic Pediatric Multiple Sclerosis Cohort from Children Hospital of Los Angeles (P02.118)
CONCLUSIONS: In this cohort of patients, predominantly of Hispanic background, with pediatric MS disability scores were lower at follow up than at diagnosis. Despite the low disability scores over time, 37% of patients changed disease modifying therapy (DMT). There is a need for better understanding of effectiveness of DMT in pediatric patients and factors effecting change in treatment. The considerations influencing treatment decisions are likely different in children than adults.Disclosure: Dr. Langille has nothing to disclose. Dr. Amezcua has received personal compensation for activities with Biogen Idec, Acorda, and No...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Langille, M., Amezcua, L., Luc, Q. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Clinical Criteria To Distinguish Vascular Myelopathy from Transverse Myelitis (P02.117)
CONCLUSIONS: A classification scale that includes clinical as well as MRI and CSF data may provide a better clinical tool to determine the likelihood of a diagnosis of inflammatory vs. vascular myelopathies. These criteria will be tested prospectively to confirm validity on a larger number of patients.Disclosure: Dr. Mealy has nothing to disclose. Dr. Jimenez has nothing to disclose. Dr. Gailloud has received personall compensation for activities with Codman Neurovascular as a consultant. Dr. Gailloud has received research support from Siemens Medical. Dr. Becker has nothing to disclose. Dr. Newsome has received personal c...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Mealy, M., Jimenez, J., Gailloud, P., Becker, D., Newsome, S., Levy, M., Pardo-Villamizar, C. Tags: P02 Pediatric MS and Other Diseases Source Type: research

The Clinical Heterogeneity of Neurosarcoidosis: A Comprehensive Study of 132 Patients (P02.116)
CONCLUSIONS: Neurological forms of sarcoidosis exhibit a heterogeneous clinical features and variable temporal profiles. Although the most common presentation of this pathology is pulmonary sarcoidosis, neurological symptoms may represent the first manifestation of the disease in more than half of the patients with neurosarcoidosis.Supported by: The Bart McLean Fund for Neuroimmunology Research and Johns Hopkins Project Restore.Disclosure: Dr. Reyes-Mantilla has nothing to disclose. Dr. Jimenez has nothing to disclose. Dr. Gonzalez has nothing to disclose. Dr. Pardo-Villamizar has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Reyes-Mantilla, M., Jimenez, J., Gonzalez, A., Pardo-Villamizar, C. Tags: P02 Pediatric MS and Other Diseases Source Type: research

The Cognitive Reserve Theory in the Setting of Pediatric-Onset Multiple Sclerosis (P02.115)
CONCLUSIONS: Our results suggest that also in POMS patients higher cognitive reserve may protect from CI. Over the follow-up, this effect remained significant in subjects with initial cognitive preservation, whereas it disappeared in subjects starting with CI. These findings may have relevant implications for counselling and rehabilitation strategies in POMS.Disclosure: Dr. Portaccio has received personal compensation for activities with Biogen Idec, Bayer, and Merck Serono. Dr. Portaccio has received research support from Biogen Idec, Bayer Schering Pharma, Merck Serono and Sanofi Aventis. Dr. Goretti has received persona...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Portaccio, E., Goretti, B., Ghezzi, A., Lori, S., Hakiki, B., Giannini, M., Pasto', L., Razzolini, L., Moiola, L., Falautano, M., Viterbo, R., Patti, F., Cilia, S., Pozzilli, C., Bianchi, V., Roscio, M., Martinelli, V., Comi, G., Trojano, M., Amato, M., o Tags: P02 Pediatric MS and Other Diseases Source Type: research

Viral and Genetic Risk Factors for Pediatric Neuromyelitis Optica (P02.114)
CONCLUSIONS: NMO patients have lower prevalence of HLA-DRB1*15:01 and HSV-1 exposure compared to those with MS but these prevalences are similar to controls. Larger case-control studies are needed to confirm these findings.Supported by: The Guthy Jackson Charitable Foundation.Disclosure: Dr. Grandhe has nothing to disclose. Dr. Graves has nothing to disclose. Dr. Mowry has received research support from Teva Neuroscience. Dr. Krupp has received personal compensation for activities with Teva Neuroscience, Biogen Idec, EMD Serono, MEDA Corp, Acorda Therapeutics, Betaseron/Bayer Healthcare, Gerson Lehrman Group, Guidepoint Gl...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Grandhe, S., Graves, J., Mowry, E., Krupp, L., Chitnis, T., Ness, J., Belman, A., Milazzo, M., Gorman, M., Weinstock-Guttman, B., Rodriguez, M., Patterson, M., James, J., Waubant, E. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Impaired Cognition without Behavioral Problems in Pediatric Clinically Isolated Syndrome (CIS) (P02.113)
CONCLUSIONS: Cognitive impairment is detectable in pediatric CIS, and is associated with EDSS but not patient- or parent-reported psychological distress.Supported by: National Multiple Sclerosis Society.Disclosure: Dr. Krupp has received personal compensation for activities with Teva Neuroscience, Biogen Idec, EMD Serono, MEDA Corp, Acorda Therapeutics, Betaseron/Bayer Healthcare, Gerson Lehrman Group, Guidepoint Global, Adler, Cohen, Harvey and Wakeman. Dr. Krupp has received royalty payments from Genzyme, Zymogenetics, Ortho-McNeil, and ER Squibb & Sons. Dr. Krupp has received research support from Genentech, Biogen ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Krupp, L., Charvet, L., Serafin, D., Julian, L., Ackerson, J., Benedict, R., Braaten, E., Brown, T., O'Donnell, E., Parrish, J., Preston, T., Zaccariello, M., Belman, A., Chitnis, T., Gorman, M., Kaufman, E., Ness, J., Patterson, M., Rodriguez, M., Wauban Tags: P02 Pediatric MS and Other Diseases Source Type: research

Clinical and Neuroimaging Features of Sarcoid Associated Myelopathy (P02.112)
CONCLUSIONS: Patients with chronic evolving tumefactive or multilevel spinal cord lesions need to be evaluated for presence of sarcoidosis and particularly those with associated meningeal or cranial nerve involvement.Supported by: The Bart McLean Fund for Neuroimmunology Research and Johns Hopkins Project Restore.Disclosure: Dr. Jimenez has nothing to disclose. Dr. Reyes-Mantilla has nothing to disclose. Dr. Tapias has nothing to disclose. Dr. Pardo-Villamizar has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Jimenez, J., Reyes-Mantilla, M., Tapias, D., Pardo-Villamizar, C. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Hemiparesis and Demyelination as Presentation of NMDA Receptor Antibody Encephalitis (P02.111)
CONCLUSIONS: NMDA antibody receptor encephalitis is usually a paraneoplastic syndrome associated with ovarian teratoma or dermoid cyst. To our knowledge, a presentation with hemiparesis; and gray and white matter involvement with mass effect mimicking a tumor has not previously been reported. The biopsy results were confusing by showing demyelination and diagnosis of atypical MS was initially considered. In conclusion, NMDA receptor encephalitis should be considered in cases with bitemporal mass lesions presented with hemiparesis. A biopsy showing demyelination does not rule out the diagnosis.Disclosure: Dr. Bollu has noth...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Bollu, P., Vellipuram, A., Sandhu, D., Miller, D., Chuquilin Arista, M. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Adult-Onset Autosomal Dominant Leukodystrophy as a Multiple Sclerosis Mimic (P02.110)
CONCLUSIONS: Adult-onset ADLD is characterized by early autonomic dysfunction and diffuse white matter disease in patients with a family history suggesting autosomal dominant inheritance. Ataxia and cognitive changes are variably seen. Unlike in MS, white matter lesions in ADLD are symmetrical and have a preference for the corticospinal tracts and brainstem with sparing of the cortex, corpus callosum and periventricular regions. Thorough history taking and careful MRI analysis in our patient prompted appropriate genetic testing and subsequent family counseling.Disclosure: Dr. Beary has nothing to disclose. Dr. Conway has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Beary, J., Conway, D. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Differential Diagnosis of Longitudinally Extensive Transverse Myelitis (P02.109)
CONCLUSIONS: NMOSD is the main diagnosis of LETM in our sample. "Idiopathic" NMO-IgG-negative LETM represent 12%, highlighting the role of other assays to study antiaquaporin-4 antibody, as well as, new antibodies associated with LETM, such as anti-MOG. Furthermore, it is essential to maintain a high index of suspicion for different possible and serious etiologies: infectious and vascular LETM may represent a critical subset with distinct therapeutic and prognosis.Disclosure: Dr. Apostolos-Pereira has received personal compensation for travel grants from Biogen Idec. Dr. Marchiori has nothing to disclose. Dr. Dellavance ha...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Apostolos-Pereira, S., Marchiori, P., Dellavance, A., Lucato, L., Jorge, F., Simm, R., Sato, D., Callegaro, D. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Bilateral, Symmetrical, Linear Enhancement of the Deep White Matter in a Radial Distribution on Brain MRI Is an Identifiable Signature of Primary Angiitis of the Central Nervous System (PACNS) (P02.108)
CONCLUSIONS: The presence of diffuse linear enhancement on gadolinium-contrasted study in a radiating fashion on brain MRI may be a diagnostic signature of PACNS.Disclosure: Dr. Ganta has nothing to disclose. Dr. Khalid has nothing to disclose. Dr. Levin has received personal compensation for activities with Serono, TEVA and Biogen-Idec as a speaker and Gerson Lehman Group as a consultant. Dr. Wood has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Ganta, K., Khalid, A., Levin, M., Wood, J. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Demyelination Associated with Tumour Necrosis Factor alpha Antagonists (P02.107)
CONCLUSIONS: Biologically active TNFα binds to 2 functionally distinct TNF receptors (TNFR). In animal models it has been shown that TNFα causes primary demyelination but those deficient in TNFα show a delayed onset with rapid progression and marked severity. TNFR1 and TNFR1 + 2 knockout mice had milder or absent symptoms. TNFR2 knockout mice had higher disease severity and demyelination. This suggests TNFα accelerates demyelination but is necessary for re-myelination. These findings coupled with clinical and radiological improvement on withdrawal of these agents in the majority of our cohort, suppo...
Source: Neurology - February 14, 2013 Category: Neurology Authors: O'Connell, K., McGuigan, C. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Levels and Suppressive Effect of Vitamin D on Cytokine Production in Japanese Patients with Multiple Sclerosis (P02.106)
CONCLUSIONS: 25(OH)D levels were lower in SPMS patients. Therefore, vitamin D supplementation is a potential treatment for MS in Japanese as well as Western populations. Vitamin D decreases production of IL-10 and TNF. However, in Japanese MS patients, the suppressive effect on TNF production by vitamin D might be weaker compared with controls.Disclosure: Dr. Niino has received personal compensation for activities with Biogen Idec, Bayer, Asahi Kasei Kuraray Medical Co., Ltd, and Novartis. Dr. Fukazawa has received personal compensation for activities with Bayer Schering Pharma, Biogen Idec, Mitsubishi Tanabe Pharma Corpor...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Niino, M., Fukazawa, T., Miyazaki, Y., Minami, N., Amino, I., Tashiro, J., Fujiki, N., Doi, S., Kikuchi, S. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Optical Coherence Tomography in Susac's Syndrome (P02.105)
CONCLUSIONS: We demonstrate for the first time in this pilot study the OCT changes in different stages of Susac's syndrome. OCT may prove to be a useful diagnostic tool in Susac's syndrome, and help differentiate it from MS. Furthermore, OCT may be a non-invasive alternative to fluorescein angiography in longitudinal follow up of these patients.Disclosure: Dr. Bernard has received personal compensation for activities with Biogen Idec and Bayer. Dr. Bernard has received research support from Biogen Idec. Dr. Romero has received personal compensation for activities with Novartis, Questcor, and Teva Neuroscience as a consulta...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Bernard, J., Romero, R., Agrawal, K., Jager, R., Rezania, K. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Outcomes of Patients with Transverse Myelitis Who Developed Venous Thromboembolism While Hospitalized (P02.104)
CONCLUSIONS: To our knowledge, this is the first study which reports significantly higher mortality rates in patients with TM who develop DVT and PE while hospitalized within the United States. This data supports prompt initiation of VTE prophylaxis in patients hospitalized with TM.Disclosure: Dr. Maiser has nothing to disclose. Dr. Adil has nothing to disclose. Dr. Roohani has nothing to disclose. Dr. Adil has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Maiser, S., Adil, M., Roohani, P., Tariq, N. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Multiple Sclerosis and Fabry Disease (P02.103)
CONCLUSIONS: Based on the results of this large study on FD in patients with MS we can conclude that FD should be considered in the differential diagnosis of MS in patients with dermatological, renal or cardiac damage.Disclosure: Dr. Garcia has nothing to disclose. Dr. Torralba has nothing to disclose. Dr. Larrode Pellicer has nothing to disclose. Dr. Pérez-Calvo has nothing to disclose. Dr. Navarro Fernandez-Balbuena has nothing to disclose. Dr. Ortelano has nothing to disclose. Dr. Iñiguez has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Garcia, L., Torralba, M. A., Larrode Pellicer, P., Perez-Calvo, J., Navarro Fernandez-Balbuena, C., Ortelano, S., Iniguez, C. Tags: P02 Pediatric MS and Other Diseases Source Type: research

A Pediatric Case of Reversible Cerebral Vasoconstriction Syndrome: Complexity of Diagnosis Amidst Co-Morbid Anxiety and Depression (P02.099)
CONCLUSIONS: RCVS has only rarely been reported in children and only once in a girl. Our case highlights the importance of considering RCVS when a child presents with severe sudden headache, even in the setting of chronic headaches. With the increased use in children of medications such as triptans and SSRIs, which are risk factors for RCVS, the incidence of RCVS in this population may also rise.Disclosure: Dr. Segal has nothing to disclose. Dr. Bain has nothing to disclose. Dr. Amin has nothing to disclose. Dr. Monoky has nothing to disclose. Dr. Thompson has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Segal, D., Bain, J., Amin, R., Monoky, D., Thompson, S. Tags: P02 Child Neurology I Source Type: research

Ictal Vasoconstriction of the Left Middle Cerebral Artery on Magnetic Resonance Angiography in Pediatric Confusional Migraine: A Case Series of Five Patients (P02.098)
CONCLUSIONS: Our cases demonstrate vasoconstriction in the L MCA territory during a confusional migraine. Vasoconstriction has also been described in some case reports of hemiplegic migraines, lending further credence to the relationship between hemiplegic and confusional migraines. These cases reinforce the role of neurovascular changes in the pathophysiology of migraines.Disclosure: Dr. Spencer has nothing to disclose. Dr. Schomer has nothing to disclose. Dr. Minster has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Spencer, K., Schomer, M., Minster, A. Tags: P02 Child Neurology I Source Type: research

Utilization and Outcomes of Cranial Computed Tomography in a Pediatric Population (P02.097)
CONCLUSIONS: Cranial CT scans performed in children are often normal, and findings infrequently change management in patients presenting with seizures, head trauma, and headache. Therefore, it may be safer to consider observation or MRI as alternatives to cranial CT imaging and its associated radiation risks, especially for certain presentations, such as seizure and headache, for which CT is low yield.Disclosure: Dr. Gardner has nothing to disclose. Dr. Hess has received personal compensation in an editorial capacity for the American Journal of Neuroradiology and the Public Library of Science. Dr. Josephson has received pe...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Gardner, M., Hess, C., Josephson, S. Tags: P02 Child Neurology I Source Type: research

Primary Dystonias and Genetic Disorders with Dystonia as Significant Feature of the Phenotype: Current Perspectives (P02.083)
CONCLUSIONS: The most up-to-date information on genetically determined primary and syndromic dystonias is presented for immediate reference to benefit practicing adult and pediatric neurologists. Further, symptom-oriented organization of the clinical entities is also provided for efficient inquiries.Disclosure: Dr. Moghimi has nothing to disclose. Dr. Bakhtiari Nejad has nothing to disclose. Dr. Jabbari has received research support from Allergan, Inc., Merz Pharma, and Ipsen. Dr. Szekely has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Moghimi, N., Bakhtiari Nejad, F., Jabbari, B., Szekely, A. Tags: P02 Ataxia, Parkinson ' s Disease, and Dystonia Source Type: research

A Possible Association between Fluticasone Propionate and Tics in Pediatric Asthmatic Patients: Two Case Reports and a Literature Review (P02.064)
CONCLUSIONS: Although this is the first case report suggesting a link between fluticasone and tics, it should nevertheless be considered in the differential diagnosis of transient motor tic development or exacerbation in the pediatric asthmatic population.Disclosure: Dr. Steele has nothing to disclose. Dr. Rosner has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Steele, M., Rosner, J. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Can Childhood Comorbidities Be Good Predictors of Functional Outcome in Adults with Tourette Syndrome? A Series of 140 Cases (P02.061)
CONCLUSIONS: In TS associated co-morbidities (ADD or OCD) do not predict functional outcome in adults compared to those without co-morbidities, however, further comprehensive age specific assessment of functional impairment in larger population might be necessary.Disclosure: Dr. Mainali has nothing to disclose. Dr. Velander has nothing to disclose. Dr. Lederman has nothing to disclose. Dr. Erenberg has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Mainali, G., Velander, L., Lederman, R., Erenberg, G. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Interim Analysis of an Open-Label, Multi-Center Study of Ecopipam, a Dopamine D1 Receptor Antagonist, for Tic Reduction in Adults with Tourette Syndrome (P02.058)
CONCLUSIONS: In this open-label study, oral ecopipam appeared to reduce tic severity without causing weight gain. To confirm treatment safety and efficacy, further double blind, placebo-controlled randomized trials in children and in adults with TS are warranted.Supported by: Psyadon Pharmaceuticals, Inc.Disclosure: Dr. Gilbert has received personal compensation in an editorial capacity for Pediatrics Review and Education Program. Dr. Gilbert has received research support from Psyadon Pharmaceuticals and Otsuka Pharmaceuticals. Dr. Budman has received research support from Psyadon Pharmaceuticals and Otsuka Pharmaceuticals...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Gilbert, D., Budman, C., Singer, H., Kurlan, R., Kwan, R., Chipkin, R. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Lasting Relief from Chronic Pain after Cerebral Infarction (P02.005)
CONCLUSIONS: This patient's stroke appeared to produce the beneficial and persistent effect of dramatic pain relief, enabling him to discontinue all analgesic medications, including methadone. The alleviation of pain after ischemic infarction is highly unusual, and possible explanations include 1) damage to both anterior cingulate gyri producing apathy of such severity that the experience of pain was markedly blunted, and 2) bilateral injury to the nucleus accumbens abolishing a cerebral region critical for the appreciation of pain and opiate-related reward.Disclosure: Dr. Burke has nothing to disclose. Dr. Anderson's spou...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Burke, H., Anderson, C., Filley, C. Tags: P02 Ethics, Pain, and Palliative Care Source Type: research

Risk Factors for Post-Traumatic Headaches after Sport-Related TBI in a Pediatric Subspecialty Clinic Population (P01.264)
CONCLUSIONS: Careful risk factor assessment may help to identify patients more likely to develop persistent PTHA who would benefit from early pediatric neurology clinic referral and intervention.Supported by: The Morris A. Hazan 2011-2012 Friends Fellowship, Child Neurology Foundation, Today and Tomorrow's Children Fund, UCLA BIRC.Disclosure: Dr. Choe has nothing to disclose. Dr. Fischer has nothing to disclose. Dr. Yudovin has nothing to disclose. Dr. McArthur has nothing to disclose. Dr. Giza has received personal compensation for activities with Medical Education Speakers Bureau and Medicolegal consultation.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Choe, M., Fischer, J., Yudovin, S., McArthur, D., Giza, C. Tags: P01 Sports Neurology Source Type: research

A Model for Developing and Incorporating a Sports Neurology Program in Neurology Residency Programs (P01.258)
CONCLUSIONS: As the demand for medical clearance of athletes by neurologists or other health care providers increase, it will be essential that neurologists understand how to diagnose and manage athletes suspected of sustaining sports concussions or other sports neurologic injuries. Incorporating this program into neurology residency programs will not only assist with the increasing demand for medical clearance but will ensure athletes safely return to play without placing them at an increased risk for post-concussive syndrome (PCS), second impact syndrome (SIS), and chronic traumatic encephalopathy (CTE).Disclosure: Dr. M...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Madey, J., Williams, N., Bodle, J., Williams, E., Edwards, J. Tags: P01 Sports Neurology Source Type: research

Sport Participation in Epileptic Children: A Review of the Literature (P01.257)
CONCLUSIONS: This review suggests that further studies should examine the epidemiology regarding seizure rates and triggers among young epileptic athletes within their respective competitive sports. This would enable physicians to provide future young athletes suffering from epilepsy with more precise data regarding risks and benefits.Disclosure: Dr. Weisser has nothing to disclose. Dr. Lewis has nothing to disclose. Dr. Sell has nothing to disclose. Dr. Veilleux has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Weisser, C., Lewis, E., Sell, E., Veilleux, M. Tags: P01 Sports Neurology Source Type: research

Sport-Related Concussion in Youth: Impact on Behavioral Functioning (P01.256)
CONCLUSIONS: These results suggest that there are measurable increases by parent report of problems with aspects of behavioral and emotional functioning within 6 months following pediatric SRC in patients presenting to a specialty TBI clinic. Of particular interest are changes in domains that involve internalizing problems, which may be less apparent to parents as well as health care providers. Tools such as the CBCL can be helpful to draw attention to areas of post-TBI difficulty that may need additional intervention.Supported by: Child Neurology Foundation/Winokur Family Foundation, Today's and Tomorrow's Children Fund, ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hartonian, I., Babikian, T., Yudovin, S., Valino, H., Fischer, J., Giza, C. Tags: P01 Sports Neurology Source Type: research

Ischemic Stroke Related to Severe Iron-Deficiency Anemia in Adults May Benefit from Blood Transfusion (P01.232)
CONCLUSIONS: Prevalence of IDA is 1-20%; it is 3.9% in our AIS population and is often related to untreated uterine bleeding. As described in the pediatric population, severe IDA may be an underlying mechanism of ischemic stroke in adults, therefore, efforts must be undertaken to identify and treat the cause of the anemia. While patients with AIS and severe IDA may receive TPA, blood transfusion may be considered as an adjuvant therapy.Supported by: SPOTRIAS P50 NS044227 & NIH Training Grant 5T 32NS0077412-12.Disclosure: Dr. Choi has nothing to disclose. Dr. Sanchez-Rotunno has nothing to disclose. Dr. Gonzales has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Choi, E., Sanchez-Rotunno, M., Gonzales, N. Tags: P01 Cerebrovascular Disease I Source Type: research

Trends in Outcome and Hospitalization Charges of Pediatric Patients Admitted with Guillain Barre Syndrome in the United States. Data from Kids' Inpatient Database (KID) 1997-2009 (P01.136)
CONCLUSIONS: There was a steady increase in the number of pediatric GBS patients from 1997 to 2009. There was a significant and steady increase in in-hospital charges of patients admitted for GBS from 1997 to 2009 that was paralleled by a significant increase in average age and a non significant reduction in the length of hospitalization.Disclosure: Dr. Sander has received personal compensation for activities with Grifols, Baxter, IPRO, and IMEDECS as speaker, scientific advisory board and independent peer review. Dr. Elenein has nothing to disclose. Dr. He has nothing to disclose. Dr. Sheikh has nothing to disclose. Dr. A...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Sander, H., Elenein, R., He, W., Sheikh, Z., Al Qudah, Z., Souayah, N. Tags: P01 Peripheral Nerve: Acute Inflammatory and Nutritional Source Type: research

The Stiff Child (P01.051)
CONCLUSIONS: SMS is an under-recognized, persistent but treatable disorder that may have childhood-onset. Serological and electrophysiological testing aid diagnosis.Disclosure: Dr. Clardy has nothing to disclose. Dr. Pittock and Mayo Clinic have a financial interest in the technology entitled "Neuromyelitis Optica Autoantibodies as a Marker for Neoplasia." This technology has been licensed to a commercial entity but no royalties have been received. Dr Sean Pittock has received research support from Alexion Pharmaceuticals, Inc. Dr. Dalmau has received personal compensation in an editorial capacity for UpToDate. Dr. Dalmau ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Clardy, S., Pittock, S., Dalmau, J., Jones, H., Renaud, D., Harper, C., Matsumoto, J., Lennon, V., McKeon, A. Tags: P01 Neurologic Manifestations: Therapeutics Source Type: research

Incidence of Kidney Stones with Topiramate Treatment in Pediatric Patients (P01.037)
CONCLUSIONS: Long-term use of TPM may result in increased incidence of asymptomatic kidney stones in the pediatric population. Hence, routine baseline and followup ultrasound of the urinary system should be recommended during the use of TPM in children.Disclosure: Dr. Mahmoud has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Mahmoud, A. Tags: P01 Clinical Neurophysiology: Therapeutics Source Type: research

Timing Matters: Early Post Traumatic Seizures in a Pediatric Population (P01.024)
CONCLUSIONS: EPTS that began >1 hour after injury were related to greater TBI severity, injury mechanism and worse outcomes. Seizures that occurred within the first hour after head trauma were not associated with TBI severity, injury mechanism or worse short-term outcomes. Very early post-TBI seizure events may include impact seizures as well as non-epileptic events (such as brief posturing, syncope, etc), which are distinct from medically observed EPTS and have different prognostic implications.Supported by: National Epifellows Foundation, Thrasher Research Foundation, Today's and Tomorrow's Children Fund, Child Neurol...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Su, M., McArthur, D., Lerner, J., Arndt, D., Matsumoto, J., Valino, H., Yudovin, S., Leung, M., Giza, C. Tags: P01 Neurocritical Care: Clinical Neurophysiology/Therapeutics Source Type: research

Efficacy of Adalimumab for the Treatment of Refractory Paediatric Acrodermatitis Continua of Hallopeau.
Abstract Abstract is missing (Letter). PMID: 23407925 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - February 14, 2013 Category: Dermatology Authors: Dini V, Barbanera S, Romanelli M Tags: Acta Derm Venereol Source Type: research

Midkine-Notch2 Signaling in Neuroblastoma
In this study, we used a MYCN transgenic model for neuroblastoma in which midkine is highly expressed in precancerous lesions of sympathetic ganglia. Genetic ablation of midkine in this model delayed tumor formation and reduced tumor incidence. Furthermore, an RNA aptamer that specifically bound midkine suppressed the growth of neuroblastoma cells in vitro and in vivo in tumor xenografts. In precancerous lesions, midkine-deficient MYCN transgenic mice exhibited defects in activation of Notch2, a candidate midkine receptor, and expression of the Notch target gene HES1. Similarly, RNA aptamer-treated tumor xenografts also sh...
Source: Cancer Research - February 14, 2013 Category: Cancer & Oncology Authors: Kishida, S., Mu, P., Miyakawa, S., Fujiwara, M., Abe, T., Sakamoto, K., Onishi, A., Nakamura, Y., Kadomatsu, K. Tags: Molecular and Cellular Pathobiology Source Type: research

Towards a role of ultrasound in children with juvenile idiopathic arthritis
US is a powerful tool for the assessment of joint synovitis in children with JIA and has been shown to be more accurate than clinical examination in detecting synovial disease. Recent studies have documented the presence of US-detected synovial pathology in children with JIA in clinical remission. US assessment enables the differentiation of joint synovitis from tenosynovitis, may help detect enthesitis and is valuable for capturing cartilage damage and early bone erosions. Guidance to local injection therapy represents an important application of US in routine care. Although US has a great potential for diffusion among pa...
Source: Rheumatology - February 14, 2013 Category: Rheumatology Authors: Lanni, S., Wood, M., Ravelli, A., Magni Manzoni, S., Emery, P., Wakefield, R. J. Tags: REVIEWS Source Type: research

CHILDHOOD TEMPERAMENT‐BASED ANTICIPATORY GUIDANCE IN AN HMO SETTING: A LONGITUDINAL STUDY
This study investigates whether individualized, anticipatory temperament guidance could benefit the parent‐child relationship and improve children's mental health over time. Parents of preschoolers in a health management organization completed a temperament questionnaire, received written parenting information tailored to their child's temperament, and were asked to complete a program evaluation questionnaire. The numbers of subsequent visits to the pediatric and psychiatry departments with anxiety, depression, attention deficit hyperactivity disorder, and other externalizing behavior diagnoses were compared over 15 year...
Source: Journal of Community Psychology - February 14, 2013 Category: Psychiatry & Psychology Authors: James R. Cameron, David C. Rice, Gregg Sparkman, Helen F. Neville Tags: ARTICLE Source Type: research

The R156H variation in IL-12Rbeta1 is not a mutation
Palamaro et al. describe a child with recurrent bronchopneumonia and very high IgE levels in which a variation, R156H, was found in the IL12RB1 gene that encodes the IL-12Rbeta1 chain. Based on the absence of this variation in 50 unrelated individuals they conclude it is a mutation. We (van de Vosse and van Dissel) feel there is no reason to suspect a defect in IL-12 signaling based on the clinical data, nor evidence for a functional defect in IL-12 signaling in this patient. In addition, the variation is not novel and known as a polymorphism. Without any functional evidence that R156H is a mutation, the current claim is n...
Source: Italian Journal of Pediatrics - February 14, 2013 Category: Pediatrics Authors: Esther van de VosseJaap van DisselLoredana PalamaroGiuliana GiardinoFrancesca SantamariaRosa RomanoAnna FuscoSilvia MontellaMariacarolina SalernoMatilde UrsiniClaudio Pignata Source Type: research

Schedule for the Scientific Meetings of the Japan Pediatric Society and Related Societies in 2013 and their hosts
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Tags: ANNOUNCEMENT Source Type: research

Erratum
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Tags: ERRATUM Source Type: research

Nocturnal enuresis as a first manifestation of acute lymphoblastic leukemia
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Authors: Keisuke Otsubo, Keiko Nomura, Toshio Miyawaki, Hirokazu Kanegane Tags: LETTER TO THE EDITOR Source Type: research

Indomethacin for preterm infants with intracranial hemorrhage
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Authors: Hiroo Chiba, Satoshi Masutani, Katsuaki Toyoshima, Rintaro Mori Tags: LETTER TO THE EDITOR Source Type: research

Recurrence of pelvic abscess from Panton–Valentine leukocidin‐positive community‐acquired ST30 methicillin‐resistant Staphylococcus aureus
Abstract A 17‐year‐old female patient (a basketball player) suffered from recurrent pelvic abscesses from methicillin‐resistant Staphylococcus aureus (MRSA). The first episode, from strain NN12, occurred in October 2004. Her cutaneous abscesses complicated into systemic progression to osteomyelitis and multifocal pelvic abscesses, adjacent to the sacroiliac joint. The second episode, abscesses at tissues adjacent to the sacroiliac joint from strain NN31A, occurred late in February 2005. The third episode, from strain NN31B, occurred on July 30, 2005, repeating the second episode. Three MRSA strains were identical in...
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Authors: Hirokazu Isobe, Dai Miyasaka, Tomoyuki Ito, Tomomi Takano, Akihito Nishiyama, Yasuhisa Iwao, Olga E. Khokhlova, Takeshi Okubo, Naoto Endo, Tatsuo Yamamoto Tags: PATIENT REPORT Source Type: research

Prenatal diagnosis of isolated congenital pyloric atresia in a sibling
Abstract Although familial occurrence of congenital pyloric atresia (CPA) has been frequently reported in the past, many of these cases were associated with epidermolysis bullosa (EB), and familial isolated CPA was a relatively rare condition. We prenatally diagnosed and successfully treated a sibling of a subject with isolated CPA, who was diagnosed prenatally by fetal ultrasonography based on the findings of a distended stomach combined with polyhydramnios. The first case was a 2398‐g female infant born at 36 weeks of gestation, who had been prenatally diagnosed as CPA. The second case, a younger sister of the first ca...
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Authors: Noriaki Usui, Masafumi Kamiyama, Takuya Kimura, Shinkichi Kamata, Keisuke Nose, Masahiro Fukuzawa Tags: PATIENT REPORT Source Type: research

Development of fatty acid calcium stone ileus after initiation of human milk fortifier
We report a case who was born with extremely low birth weight infant and had experienced abdominal operation for necrotizing enterocolitis, eventually developed ileus due to fatty acid calcium stones after giving human milk fortifier. He had developed necrotizing enterocolitis on day 30 of his age, such that we performed enterectomy and ileostomy. He could not tolerate enteral feeding fully, because intestinal fistula infection was repeated. Although we administered hindmilk, he grew up slowly and he suffered cholestasis as well. We performed end‐to‐end anastomosis to prevent fistula infections on day 87. After this op...
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Authors: Masahiko Murase, Tokuo Miyazawa, Motohiro Taki, Motoichiro Sakurai, Fumihiro Miura, Katsumi Mizuno, Kazuo Itabashi, Akira Toki Tags: PATIENT REPORT Source Type: research

T‐cell large granular lymphocyte leukemia in a child with anemia and Crohn's disease
We report a child with T‐LGL leukemia who presented with anemia and went on to develop Crohn's disease. Although prednisolone treatment proved effective in the treatment of anemia, large granular lymphocyte counts increased as the doses were tapered. T‐cell rearrangement studies revealed a clonal rearrangement of the TCR Vβ/jβ2 gene. Concurrently, the patient developed severe diarrhea. Inflammatory changes across the upper and lower intestines led to the diagnosis of Crohn's disease. This case highlights that T‐LGL leukemia could be occurred in children. Flow cytometry and/or T‐cell gene rearrangement studies are...
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Authors: Kensuke Kondoh, Mizuho Morimoto, Dai Keino, Ryo Oyama, Chiai Nagae, Tomoko Ashikaga, Katsuhiro Arai, Atsuko Nakazawa, Akitoshi Kinoshita Tags: PATIENT REPORT Source Type: research

Novel p53 splicing site mutation in Li‐Fraumeni‐like syndrome with osteosarcoma
We describe a 15‐year‐old girl with a novel germline p53 splice site mutation who developed an osteosarcoma. She received several cycles of chemotherapy with complete resection of the primary tumor without amputation, and has maintained remission for 18 months. Li‐Fraumeni‐like syndrome was suspected based on familial history. Sequence analysis revealed the presence of a novel germline p53 gene mutation resulting in a G to A transition at position +1 at the donor splice site of intron 6, creating a 6 amino acid insertion. This case provides interesting insight into the phenotype‐genotype correlation in LFL sy...
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Authors: Naoto Sakurai, Shotaro Iwamoto, Yoshihiro Miura, Tomoki Nakamura, Akihiko Matsumine, Junji Nishioka, Kaname Nakatani, Yoshihiro Komada Tags: PATIENT REPORT Source Type: research

Characterization of AQP‐2 gene mutation (R254Q) in a family with dominant nephrogenic DI
Abstract We identified the AQP‐2 gene mutation (R254Q) in a family with dominant NDI. The patient studied here has NDI with partial response to the anti‐diuretic effect of AVP and dDAVP. Hereditary NDI seems to have the uniform clinical manifestations, but this might only reflect the information on screened patients with clear clinical presentations. It may be that a milder form of NDI has been overlooked due to a lack of genetic identification. Gene mutation analysis should be considered even in patients with mild NDI symptoms. Fortunately, both V2R and AQP2 genes are small and can be easily analyzed.
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Authors: Yoko Shida, Hisafumi Matsuoka, Motoko Chiga, Shinichi Uchida, Sei Sasaki, Shigetaka Sugihara Tags: PATIENT REPORT Source Type: research

Familial cases with MYH9 disorders caused by MYH9 S96L mutation
We report familial cases with MYH9 disorders: a 1‐year‐old Japanese boy who presented only with macrothrombocytopenia, and his 33‐year‐old father who had been diagnosed with refractory chronic idiopathic thrombocytopenic purpura, and suffered from hearing loss and chronic renal failure. Peripheral blood smears revealed giant platelets but no Döhle body‐like cytoplasmic inclusion bodies in neutrophils. Heterozygous MYH9 S96L mutations were found in the patient and his father, resulting in the diagnosis of a familial case with MYH9 disorders. The possibility of MYH9 disorders including Epstein syndrome sho...
Source: Pediatrics International - February 14, 2013 Category: Pediatrics Authors: Shizuko Murayama, Masaharu Akiyama, Hiroyuki Namba, Yasuyuki Wada, Hiroyuki Ida, Shinji Kunishima Tags: PATIENT REPORT Source Type: research