Perinatology & Neonatology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
37217 records returned
DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection
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Persistent colonization with the gastric bacterial pathogen Helicobacter pylori causes gastritis and predisposes infected individuals to gastric cancer. Conversely, it is also linked to protection from allergic, chronic inflammatory, and autoimmune diseases. We demonstrate here that H. pylori inhibits LPS-induced maturation of DCs and reprograms DCs toward a tolerance-promoting phenotype. Our results showed that DCs exposed to H. pylori in vitro or in vivo failed to induce T cell effector functions. Instead, they efficiently induced expression of the forkhead transcription factor FoxP3, the master regulator of Tregs, in na...
Source: Journal of Clinical Investigation - February 6, 2012 Category: Biomedical Science Authors: Mathias Oertli, Malin Sundquist, Iris Hitzler, Daniela B. Engler, Isabelle C. Arnold, Sebastian Reuter, Joachim Maxeiner, Malin Hansson, Christian Taube, Marianne Quiding-Järbrink, Anne Müller Source Type: research
Tissue Distribution of Anidulafungin in Neonatal RatsEmail this article to a colleague.
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In conclusion, anidulafungin distributes to bone, brain, and heart tissues of neonatal rats; such results are supportive of further investigation of efficacy against infections involving bone, brain, and heart tissues. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - February 6, 2012 Category: Perinatology & Neonatology Authors: Sharon L. RippJalal A. AramChristopher J. BowmanGary ChmielewskiUmberto ConteDavid M. CrossHongying GaoElise M. LewisJian LinPing LiuHaran T. Schlamm Tags: Original Article Source Type: research
The Effect of Adriamycin Exposure on the Notochord of Mouse EmbryosEmail this article to a colleague.
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The notochord has important structural and signaling properties during vertebrate development with key roles in patterning surrounding tissues, including the foregut. The adriamycin mouse model is an established model of foregut anomalies where exposure of embryos in utero to the drug adriamycin leads to malformations including oesophageal atresia and tracheoesophageal fistula. In addition to foregut abnormalities, treatment also causes branching, displacement, and hypertrophy of the notochord. Here, we explore the hypothesis that the notochord may be a primary target of disruption leading to abnormal patterning of the for...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - February 6, 2012 Category: Perinatology & Neonatology Authors: Piotr HajdukAlison MayPrem PuriPaula Murphy Tags: Original Article Source Type: research
Cannabinoid Receptor 1 Signaling in Embryo NeurodevelopmentEmail this article to a colleague.
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In utero exposure to tetrahydrocannabinol, the psychoactive component of marijuana, is associated with an increased risk for neurodevelopmental defects in the offspring by interfering with the functioning of the endocannabinoid (eCB) system. At the present time, it is not clearly known whether the eCB system is present before neurogenesis. Using an array of biochemical techniques, we analyzed the levels of CB1 receptors, eCBs (AEA and 2‐AG), and the enzymes (NAPE‐PLD, DAGLα, DAGLβ, MAGL, and FAAH) involved in the metabolism of the eCBs in chick and mouse models during development. The findings demonstrate the presenc...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - February 6, 2012 Category: Perinatology & Neonatology Authors: Delphine PsychoyosK. Yaragudri VinodJin CaoShan XieRichard L. HysonBogdan WlodarczykWeimin HeThomas B. CooperBasalingappa L. HungundRichard H. Finnell Tags: Original Article Source Type: research
Effect of In Utero Wi‐Fi Exposure on the Pre‐ and Postnatal Development of RatsEmail this article to a colleague.
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CONCLUSIONSIn the present study, no teratogenic effect of repeated exposures to the Wi‐Fi wireless communication signal was demonstrated even at the highest level of 4 W/kg. The results from this screening study aimed at investigating Wi‐Fi effects, strengthen the previous conclusions that teratology and development studies have not detected any noxious effects of exposures to mobile telephony‐related RF fields at exposure levels below standard limits. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - February 6, 2012 Category: Perinatology & Neonatology Authors: Florence Poulletier de GannesEmmanuelle HaroAnnabelle HurtierMurielle TaxileAxel AthaneSaliha Ait‐AissaHiroshi MasudaYann PercherncierGilles RuffiéBernard BillaudelPhilippe DufourBernard VeyretIsabelle Lagroye Tags: Original Article Source Type: research
Reproductive and Neurobehavioral Effects of Clothianidin Administered to Mice in the DietEmail this article to a colleague.
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Clothianidin was given in the diet to provide levels of 0% (control), 0.003%, 0.006%, and 0.012% from 5 weeks of age of the F0 generation to 11 weeks of age of the F1 generation in mice. Selected reproductive and neurobehavioral parameters were measured. In exploratory behavior in the F0 generation, average time of movement, number of rearing, and rearing time of adult males increased significantly in a dose‐related manner. There was no adverse effect of clothianidin on litter size, litter weight, or sex ratio at birth. The average body weight of male and female offspring was increased significantly in a dose‐related m...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - February 6, 2012 Category: Perinatology & Neonatology Authors: Toyohito Tanaka Tags: Original Article Source Type: research
Heavy smoking during pregnancy as a marker for other risk factors of adverse birth outcomes: a population-based study in British Columbia, CanadaEmail this article to a colleague.
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Conclusion:
Our data suggests that self reports of heavy smoking early in pregnancy could be used as a marker for lifestyle risk factors that in combination with smoking influence birth outcomes. This information may be used for planning targeted intervention programs for not only smoking cessation, but potentially other support services such as nutrition and healthy pregnancy education. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - February 6, 2012 Category: Consumer Health News Authors: Anders EricksonLaura Arbour Source Type: research
Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death.Email this article to a colleague.
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Abstract
Hypoxia-inducible pro-death protein BNIP3 (BCL-2/adenovirus E1B 19-kDa interacting protein 3), provokes mitochondrial permeabilization causing cardiomyocyte death in ischemia-reperfusion injury. Inhibition of autophagy accelerates BNIP3-induced cell death, by preventing removal of damaged mitochondria. We tested the hypothesis that stimulating autophagy will attenuate BNIP3-induced cardiomyocyte death. Neonatal rat cardiac myocytes (NRCMs) were adenovirally transduced with BNIP3 (or LacZ as control; at multiplicity of infection = 100); and autophagy was stimulated with rapamycin (100 nM). Cell death was as...
Source: Autophagy - February 5, 2012 Category: Cytology Authors: Ma X, Godar RJ, Liu H, Diwan A Tags: Autophagy Source Type: research
[Articles] Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic reviewEmail this article to a colleague.
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Intrauterine and neonatal insults have a high risk of causing substantial long-term neurological morbidity. Comparable cohort studies in resource-poor regions should be done to properly assess the burden of these conditions, and long-term outcomes, such as chronic disease, and to inform policy and programme investments. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Michael K Mwaniki, Maurine Atieno, Joy E Lawn, Charles RJC Newton Tags: Articles Source Type: research
[Correspondence] Improving health: can Pakistan prioritise?Email this article to a colleague.
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Pakistan lags far behind in meeting the Millennium Development Goals. Neonatal mortality is responsible for 57% of all deaths in children younger than 5 years in the country, and Pakistan has the highest neonatal mortality rate in the region. The under-5 mortality rate has decreased by 24% since 1990. However, both rates have remained more or less static in the poorest income quintile. With the devolution of the Ministry of Health last year, Pakistan faces the challenge of developing the much needed provincial infrastructure that would integrate the comprehensive efforts of various stakeholders in promoting better health o...
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Sabeena Jalal Tags: Correspondence Source Type: research
[Comment] Behavioural problems from perinatal and neonatal insultsEmail this article to a colleague.
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The nature, scale, and interactions of behavioural disorders after neonatal and perinatal insults, including preterm birth and infectious diseases, are not well understood. In The Lancet, Michael Mwaniki and colleagues present a broad systematic review of the type and probability of development of a range of neurodevelopmental sequelae, in which they have included 153 research studies and 22 161 liveborn children. The authors report a very high overall prevalence of at least one deficit in any domain (median risk 39·4%, IQR 20·0–54·8%). (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Lucy C Thompson, Christopher Gillberg Tags: Comment Source Type: research
Improving test properties for neonatal cystic fibrosis screening in the Netherlands before the nationwide start by May 1st 2011Email this article to a colleague.
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Abstract When new technical possibilities arise in health care, often attunement is needed between different actors from the perspectives
of research, health care providers, patients, ethics and policy. For cystic fibrosis (CF) such a process of attunement in
the Netherlands started in a committee of the Health Council on neonatal screening in 2005. In the balancing of pros and cons
according to Wilson and Jungner criteria, the advantages for the CF patient were considered clear, even though CF remains
a severe health problem with treatment. Nevertheless, screening was not started then, mainly since the spec...
Source: Journal of Inherited Metabolic Disease - February 3, 2012 Category: Internal Medicine Tags: Journal of Inherited Metabolic Disease Source Type: research
Acid-Base Parameters for Predicting Magnetic Resonance Imaging Measures of Neurologic Outcome after Perinatal Hypoxia-Ischemia: Is the Strong Ion Gap Superior to Base Excess and Lactate?Email this article to a colleague.
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Amer J PerinatolDOI: 10.1055/s-0031-1300969We conducted this study to compare the strong ion gap (SIG) with base excess (BE) and lactate for predicting neurologic outcome measured by magnetic resonance imaging (MRI) in newborns with hypoxic-ischemic encephalopathy (HIE). In a retrospective cohort of 39 newborns with HIE treated with whole-body surface cooling (n = 17) and no cooling (n = 22), we measured blood SIG, BE, and lactate at 4, 24, and 48 hours after birth, and determined cerebral injury severity by T1-, T2-, and diffusion-weighted MRI scores at age 5 days. Lower SIG levels correlated with better neurologi...
Source: American Journal of Perinatology - February 3, 2012 Category: Perinatology & Neonatology Authors: Mann, ChristianLatal, BeatricePadden, BethScheer, IaninaGoebel, GeorgBernet, Vera Source Type: research
Low HCMV DNA Copies Can Establish Infection and Result in Significant Symptoms in Extremely Preterm Infants: A Prospective StudyEmail this article to a colleague.
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We examined whether the number of HCMV DNA copies in BM is related to HCMV infection in very low birth weight (VLBW) infants. We identified 11 pairs of VLBW infants and mothers. BM samples were collected every week until 10 weeks postpartum. Urine samples were collected from the infants within 1 week, at 6 to 8 weeks, at discharge, and whenever HCMV infection was suspected. HCMV DNA in BM was positive in 7 of 11 mothers and reached a peak at 4 to 5 weeks postpartum. Of the 11, 5 infants were determined to be infected from positive HCMV DNA in the urine, despite the fact that BM was used after being frozen. Of the five, fou...
Source: American Journal of Perinatology - February 3, 2012 Category: Perinatology & Neonatology Authors: Wakabayashi, HitomiMizuno, KatsumiKohda, ChikaraNegoro, TakaharuMaekawa, ChiakiSawato, SatomiTanaka, KazuoNakano, YasukoMurayama, JunichirouTaki, MotohiroMiyazawa, TokuoMurase, MasahikoAizawa, MadokaNakano, YuuyaSakurai, MotoichiroTakahashi, KenichiroItab Source Type: research
Blunted Heart Rate Circadian Rhythms in Small for Gestational Age Infants during the Early Neonatal PeriodEmail this article to a colleague.
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Amer J PerinatolDOI: 10.1055/s-0031-1300970Infants born with intrauterine growth restriction are at increased risk for adverse cardiovascular outcomes in neonatal and later life. Although circadian rhythm is a prognostic marker of cardiovascular health, the concern over the circadian rhythm of these infants is rarely observed. To determine the influence of intrauterine growth retardation on the pattern of circadian rhythm, heart rate (HR) circadian rhythmicity was analyzed in 39 small for gestational age (SGA; birth weight and height below <−2.0 standard deviation score [SDS]) and 117 appropriate for gestational age (...
Source: American Journal of Perinatology - February 3, 2012 Category: Perinatology & Neonatology Authors: Begum, Esmot AraBonno, MotokiSasaki, NaoyaOmori, YusukeMatsuda, KazuyukiSugino, NorikoTanaka, ShigekiYamamoto, HatsumiIdo, Masaru Source Type: research
Impact of maternal characteristics on fetal growth in the third trimester of pregnancy. A population‐based studyEmail this article to a colleague.
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Conclusions. Fetal third trimester growth was positively associated with increasing maternal BMI, height, and pre‐existing diabetes mellitus, and was negatively associated with maternal smoking. No significant association between fetal growth and maternal parity or gestational diabetes mellitus was detected when adjustments were made for gestational age and the other maternal characteristics. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - February 3, 2012 Category: Radiology Authors: Gun LindellKarel MaršálKarin Källén Tags: Original Paper Source Type: research
Disproportionate body composition and perinatal outcome in large‐for‐gestational‐age infants to mothers with type 1 diabetesEmail this article to a colleague.
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Conclusions High birthweight, irrespective of body proportionality, is a risk factor for neonatal complications in offspring of women with type 1 diabetes. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - February 3, 2012 Category: OBGYN Authors: M PerssonD PasupathyU HansonM Norman Source Type: research
Prediction of Pediatric Outcome after Prenatal Diagnosis and Expectant Antenatal Management of Congenital Cystic Adenomatoid MalformationEmail this article to a colleague.
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Fetal Diagn Ther (DOI:10.1159/000331936) (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - February 2, 2012 Category: Perinatology & Neonatology Source Type: research
St. Elizabeth denied NICU unitEmail this article to a colleague.
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St. Elizabeth Healthcare has been denied Kentucky approval to open an advanced neonatal intensive care unit.
The hospital system applied in 2009 for the Level III NICU designation. But it failed to convince the Kentucky Cabinet for Health and Family Services the Kentucky needs the 12-bed service.
A spokeswoman for the organization said St. Elizabeth is likely to appeal the decision.
St. Elizabeth hoped to lure back the 990 Northern Kentucky women who leave the state to have their babies at Cincinnati Children’s Hospital Medical Center or elsewhere... (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 2, 2012 Category: Pharmaceuticals Authors: James Ritchie Source Type: research
What is the Evidence for the use of Adrenaline in the Treatment of Neonatal Hypotension?Email this article to a colleague.
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(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents) - February 2, 2012 Category: Cardiology Authors: Mahoney, LiamCrook, DavidN Walter, KerstinSherman, EllaRabe, Heike Tags: Articles Source Type: research
The Size 1 ProSeal™ laryngeal mask airway in infants: a randomized, noncrossover study with the Classic™ laryngeal mask airwayEmail this article to a colleague.
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Conclusions: We conclude that the size 1 PLMA is a stable, safe, and efficacious airway control device during neonatal and infant anesthesia, allowing higher peak airway pressure during positive pressure ventilation, with fewer mask displacements and gastric insufflations than the cLMA. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - February 2, 2012 Category: Anesthesiology Authors: Maite López‐GilIgnacio MantillaTeresa BlancoEnrique TeigellMónica HerviasRosa Fernández‐López Tags: ORIGINAL ARTICLE Source Type: research
Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigsEmail this article to a colleague.
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Conclusion Dynamic FDG PET detected decreased cerebral glucose metabolism early after perinatal hypoxia in piglets. The decrease in CMRgl may indicate early changes of mild cerebral hypoxia–ischaemia. No significant effect of hyperoxic resuscitation on the degree
of hypometabolism was found in this early phase after hypoxia. Cerebral FDG PET can provide new insights into mechanisms of
perinatal hypoxic–ischaemic injury where early detection plays an important role in instituting therapy.
Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00259-011-2055-yAuthors
Charlotte ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 2, 2012 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: research
Use of non-steroidal anti-inflammatory drugs in pregnancy: impact on the fetus and newborn.Email this article to a colleague.
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This article discusses in detail the placental transfer and metabolism of NSAIDs, and the adverse impact of prenatal NSAID exposure on the offspring.
PMID: 22299823 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 2, 2012 Category: Drugs & Pharmacology Authors: Antonucci R, Zaffanello M, Elisabetta P, Porcella A, Cuzzolin L, Pilloni MD, Fanos V Tags: Curr Drug Metab Source Type: research
Direct experimental evidence that early‐life farm environment influences regulation of immune responsesEmail this article to a colleague.
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Conclusion: Here, we provide the first direct evidence, derived from intervention, that components of the early‐life environment present on farms profoundly affects both local development of regulatory components of the mucosal immune system and immune responses to food proteins at weaning. We propose that neonatal piglets provide a tractable model which allows maternal and treatment effects to be statistically separated. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - February 2, 2012 Category: Allergy & Immunology Authors: Marie C. LewisCharlotte F. InmanDilip PatelBettina SchmidtImke MulderBevis MillerBhupinder P. GillJohn PluskeDenise KellyChristopher R. StokesMichael Bailey Tags: ORIGINAL ARTICLE Source Type: research
History of the birth certificate: from inception to the future of electronic dataEmail this article to a colleague.
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& S G Golombek (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: H L BrumbergD DozorS G Golombek Tags: history of medicine birth certificate vital statistics Source Type: research
Nasal intermittent positive pressure ventilation after surfactant treatment for respiratory distress syndrome in preterm infantsEmail this article to a colleague.
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& R F Soll (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: R RamanathanK C SekarM RasmussenJ BhatiaR F Soll Tags: respiratory distress syndrome surfactant preterm bronchopulmonary dysplasia NIPPV NCPAP Source Type: research
Effect of heparin and other factors associated with complications of peripherally inserted central venous catheters in neonatesEmail this article to a colleague.
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& H Akinbi (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: B IsemannR SorrelsH Akinbi Tags: percutaneous central venous catheter occlusion catheter removal Source Type: research
NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restrictionEmail this article to a colleague.
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urakowski
& S K Warfield (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: H AlsF H DuffyG McAnultyS C ButlerL LightbodyS KostaN I WeisenfeldR RobertsonR B ParadS A RingerJ G BlickmanD ZurakowskiS K Warfield Tags: NIDCAP intrauterine growth restriction preterm infants APIB EEG MRI Source Type: research
Does increasing body mass index affect cerclage efficacy?Email this article to a colleague.
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Does increasing body mass index affect cerclage efficacy?
Journal of Perinatology advance online publication, February 2, 2012.
doi:10.1038/jp.2011.198
Authors: S H Poggi, N A Vyas, J C Pezzullo, H J Landy
& A Ghidini (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: S H PoggiN A VyasJ C PezzulloH J LandyA Ghidini Tags: body mass index cerclage cervical insufficiency obesity preterm delivery Source Type: research
Evaluation of cerebrospinal fluid parameters in preterm infants with intraventricular reservoirsEmail this article to a colleague.
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& G Natarajan (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: M BajajM Lulic-BoticaG Natarajan Tags: cerebrospinal fluid preterm infants intraventricular reservoir Source Type: research
Domestic violence screening of obstetric triage patients in a military populationEmail this article to a colleague.
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& E F Magann (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: M A LutgendorfA ThagardP D RockswoldJ M BuschE F Magann Tags: domestic violence emergency care military physical abuse pregnancy Source Type: research
Radiological clues to the early diagnosis of hypochondroplasia in the neonatal period: Report of two patientsEmail this article to a colleague.
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We report on the clinical and radiological findings in two HCH children with a FGFR3 mutation. In both children, fetal US showed short femora and relatively increased biparietal diameter (BPD). However, postnatal assessment failed to make a specific diagnosis in the neonatal period. The correct diagnosis of HCH was accomplished by reassessment after exacerbation of postnatal short stature. In retrospective radiological review, the radiological findings relevant to HCH were discernible more easily in the neonatal period than at age of 3 years. © 2012 Wiley Periodicals, Inc. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - February 2, 2012 Category: Genetics & Stem Cells Authors: Tomoko SaitoKeisuke NagasakiGen NishimuraMasaki TakagiTomonobu HasegawaMakoto Uchiyama Tags: Clinical Report Source Type: research
Chromosome 22q11.2 duplication is rare in a population‐based cohort of Danish children with cardiovascular malformationsEmail this article to a colleague.
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AbstractThe prevalence of the 22q11.2 duplication is unknown in children with cardiovascular malformations (CVMs). As most individuals with the duplication are detected in the search for other conditions, especially the 22q11.2 deletion, CVMs associated with the duplication are subject to referral bias. We circumvented this bias by investigating the prevalence of the 22q11.2 duplication in a population‐based cohort of children with CVMs. The study population was defined as children born in 2000–2008, who were registered in the Danish National Patient Registry with a diagnosis of CVM from one of the two national univers...
Source: American Journal of Medical Genetics Part A - February 2, 2012 Category: Genetics & Stem Cells Authors: Peter AgergaardCharlotte OlesenJohn Rosendahl ØstergaardMichael ChristiansenKarina Meden Sørensen Tags: Research Article Source Type: research
Clinical Characteristics Of Neonates With VACTERL AssociationEmail this article to a colleague.
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AbstractBackground: The VACTERL association (VA) is the nonrandom co‐occurrence of Vertebral anomalies, Anal atresia, Cardiovascular malformations, Tracheo‐esophageal fistula and/or Esophageal atresia, Renal anomalies, and/or Limb‐anomalies, and is referred to the first letters of its components. Studies investigating the clinical characteristics of VA patients and probing of the observed current six component types are limited, and none of them is focused to neonates. Clinical characteristics of our patients diagnosed as having VA in the newborn period is investigated.Methods: We retrospectively reviewed the n...
Source: Pediatrics International - February 2, 2012 Category: Pediatrics Authors: Oral AkgunCaner IbrahimYigiter MuratKantarci MecitOlgun HasimCeviz NaciSalman Ahmet Bedii Source Type: research
The neonate presenting with temperature symptoms: Role in the diagnosis of early onset sepsisEmail this article to a colleague.
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Conclusions: Every seventh newborn hospitalized at our neonatal intensive care unit developed fever, hypothermia and/or temperature instability during the first three days of life. Two thirds of them had culture proven or clinical sepsis. Temperature symptoms were rarely observed in EOS negative newborns (8%) but despite low sensitivity highly specific for bacterial infection in preterm and term newborns.© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society (Source: Pediatrics International)
Source: Pediatrics International - February 2, 2012 Category: Pediatrics Authors: Nora HoferWilhelm MüllerBernhard Resch Source Type: research
Use of dosulepin in pregnancyEmail this article to a colleague.
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Source: UK Teratology Information Service
Area: Evidence > Drugs in Pregnancy
SUMMARY: Dosulepin (formerly known as dothiepin) is a tricyclic antidepressant used in the treatment of depression, particularly where sedation is required.
There is very little published data regarding the use of dosulepin in pregnancy. Neonatal withdrawal symptoms may occur following chronic use or use near the time of delivery of any antidepressant. The neonate should be monitored for adverse effects such as drowsiness, jitteriness, hyperexcitability and suckling problems. Some studies have suggested that exposur...
Source: NeLM - Drugs in Pregnancy - February 2, 2012 Category: OBGYN Source Type: news
Risk of Suicide, Self-injury, and Psychiatric Service UseRisk of Suicide, Self-injury, and Psychiatric Service UseEmail this article to a colleague.
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Can perinatal experiences, such as birth complications, predict later mental health problems in children and adolescents? BMC Public Health (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 1, 2012 Category: Consumer Health News Tags: Psychiatry Journal Article Source Type: news
Replicability of structural models of the Edinburgh Postnatal Depression Scale (EPDS) in a community sample of postpartum African American women with low socioeconomic statusEmail this article to a colleague.
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Abstract The Edinburgh Postnatal Depression Scale (EPDS) is increasingly used in public health and social service programs serving
postpartum women of racially, ethnically, and socioeconomically diverse backgrounds at risk for depression. However, we know
little about its factor structure across groups of women with implications for measuring symptom levels in research. This
study evaluated the underlying structure of the EPDS using a confirmatory factor analyses model comparison approach of five
factor models from the literature in a purposive community sample of 169 postpartum African American women of low...
Source: Archives of Women's Mental Health - February 1, 2012 Category: Psychiatry & Psychology Tags: Archives of Women's Mental Health Source Type: research
The Size 1 ProSeal™ laryngeal mask airway in infants: a randomized, noncrossover study with the Classic™ laryngeal mask airway.Email this article to a colleague.
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Conclusions: We conclude that the size 1 PLMA is a stable, safe, and efficacious airway control device during neonatal and infant anesthesia, allowing higher peak airway pressure during positive pressure ventilation, with fewer mask displacements and gastric insufflations than the cLMA.
PMID: 22295870 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - February 1, 2012 Category: Anesthesiology Authors: López-Gil M, Mantilla I, Blanco T, Teigell E, Hervias M, Fernández-López R Tags: Paediatr Anaesth Source Type: research
Phosphorylation of Stim1 at serine575 via netrin-2/Cdo-activated ERK1/2 is critical for the promyogenic function of Stim1.Email this article to a colleague.
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In this study we investigated the functional interaction between Cdo and Stim1 in myogenic differentiation. Overexpression and depletion of Stim1 enhanced or decreased myotube formation, respectively. Interestingly Stim1 protein levels were decreased in Cdo-deficient perinatal hindlimb muscles or primary myoblasts; this correlates with defective NFATc3 activation in Cdo(-/-) myoblasts upon differentiation. Forced activation of NFATc3 by overexpression of Calcineurin restored differentiation of Cdo-depleted C2C12 myoblasts. Furthermore, Cdo and Stim1 formed a complex in 293T cells or in differentiating C2C12 myoblasts. The ...
Source: Mol Biol Cell - February 1, 2012 Category: Molecular Biology Authors: Lee HJ, Bae GU, Leem YE, Choi HK, Kang TM, Cho H, Kim ST, Kang JS Tags: Mol Biol Cell Source Type: research
Controlled collagen crosslinking process in tissue‐engineered fibroblast sheets for preventing scar contracture on the surface of lungsEmail this article to a colleague.
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AbstractFor preventing the scar contracture of host tissue and adjusting the tensile strength of covering cell sheets, a controlled collagen crosslinking step process in the preparation of skin‐fibroblast sheets for repairing wound was investigated by using β‐aminopropionitrile (BAPN), a collagen crosslinking inhibitor, in the culture medium. Skin fibroblasts obtained from neonatal rats were cultured in medium with and without 0.25 mm BAPN for 7 days and seeded on temperature‐responsive culture dishes. After the confluent cells were non‐invasively harvested as a monolithic cell sheet, two cell sheets were tran...
Source: Journal of Tissue Engineering and Regenerative Medicine - February 1, 2012 Category: Molecular Biology Authors: Masato KanzakiMasayuki YamatoRyo TakagiTakuma KikkawaTamami IsakaTeruo OkanoTakamasa Onuki Tags: Research Article Source Type: research
Development and validation of serum bilirubin nomogram to predict the absence of risk for severe hyperbilirubinaemia before discharge: a prospective, multicenter studyEmail this article to a colleague.
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Conclusion:
The hour-specific TSB nomogram is able to predict all neonates without risk of non physiologic hyperbilirubinemia only after 48 to 72 hours of life. The combination of TSB determination and risk factors for hyperbilirubinemia could facilitate a safe discharge from the hospital and a targeted intervention and follow-up. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 1, 2012 Category: Pediatrics Authors: Costantino RomagnoliEloisa TiberiGiovanni BaroneMario De CurtisDaniela RegoliPiermichele PaolilloSimonetta PiconeStefano AnaniaMaurizio FinocchiValentina CardielloLucia GiordanoValentina PaolucciEnrico Zecca Source Type: research
Developmental outcome of very low birth weight infants in a developing countryEmail this article to a colleague.
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Conclusion:
Although the neurodevelopmental outcome of this group of VLBW infants was within the normal range, with a low incidence of cerebral palsy, these results may reflect the low survival of babies with a birth weight below 900 grams. In addition, mean subscale scores were low and one third of the babies were identified as "at risk", indicating that this group of babies warrants long-term follow up into school going age. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - February 1, 2012 Category: Pediatrics Authors: Daynia BallotJoanne PottertonTobias ChirwaNicole HilburnPeter Cooper Source Type: research
Neonatal Drug WithdrawalEmail this article to a colleague.
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Maternal use of certain drugs during pregnancy can result in transient neonatal signs consistent with withdrawal or acute toxicity or cause sustained signs consistent with a lasting drug effect. In addition, hospitalized infants who are treated with opioids or benzodiazepines to provide analgesia or sedation may be at risk for manifesting signs of withdrawal. This statement updates information about the clinical presentation of infants exposed to intrauterine drugs and the therapeutic options for treatment of withdrawal and is expanded to include evidence-based approaches to the management of the hospitalized infant who re...
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Authors: Hudak, M. L., Tan, R. C., THE COMMITTEE ON DRUGS, THE COMMITTEE ON FETUS AND NEWBORN Tags: Therapeutics & Toxicology From the American Academy of Pediatrics Source Type: research
Genetic and Environmental Components of Neonatal Weight Gain in Preterm InfantsEmail this article to a colleague.
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CONCLUSIONS:
This high heritability estimate could suggest using this set of criteria to identify genes that regulate postnatal weight gain or failure. (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Authors: Brescianini, S., Giampietro, S., Cotichini, R., Lucchini, R., De Curtis, M. Tags: Article Source Type: research
Intrapartum Temperature Elevation, Epidural Use, and Adverse Outcome in Term InfantsEmail this article to a colleague.
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CONCLUSIONS:
The proportion of infants experiencing adverse outcomes increased with the degree of epidural-related maternal temperature elevation. Epidural use without temperature elevation was not associated with any of the adverse outcomes we studied. (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Authors: Greenwell, E. A., Wyshak, G., Ringer, S. A., Johnson, L. C., Rivkin, M. J., Lieberman, E. Tags: Premature & Newborn Article Source Type: research
Incidence and Timing of Presentation of Necrotizing Enterocolitis in Preterm InfantsEmail this article to a colleague.
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CONCLUSIONS:
Among infants <33 weeks’ gestation, NEC appears to present at mean age of 7 days in more mature infants, whereas onset of NEC is delayed to 32 days of age in smaller, lower GA infants. Further studies are required to understand the etiology of this disease process. (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Authors: Yee, W. H., Soraisham, A. S., Shah, V. S., Aziz, K., Yoon, W., Lee, S. K., the Canadian Neonatal Network Tags: Premature & Newborn Article Source Type: research
Genetic and Environmental Components of Neonatal Weight Gain in Preterm InfantsEmail this article to a colleague.
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Several studies have focused on birth weight heritability, reporting results that range between 40% and 80%. Few studies have focused on the process of weight gain and were mainly based on heterogeneous samples of infants.
The present work looks at a uniform set of healthy preterm newborn twins. The resulting high heritability estimate could suggest using the inclusion criteria to identify genes that regulate postnatal weight gain or failure. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research
Intrapartum Temperature Elevation, Epidural Use, and Adverse Outcome in Term InfantsEmail this article to a colleague.
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Previous observational studies and randomized trials have reported an association between the use of epidural analgesia for pain relief in labor and intrapartum maternal fever. Studies have also reported an increase in adverse neonatal outcomes with intrapartum maternal fever.
Among low-risk women receiving epidural analgesia, intrapartum maternal temperature >99.5°F was associated with adverse neonatal outcomes, with the rate of adverse outcomes increasing directly with maximum maternal temperature. Without temperature elevation, epidural use was not associated with adverse neonatal outcomes. (Read the full article...
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research
Index of Suspicion in the Nursery * Case 1: Bloody Stool at 1 Day of Age in a Term Newborn * Case 2: Abnormal Fetal Movements and Early Neonatal CollapseEmail this article to a colleague.
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(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2012 Category: Pediatrics Authors: Marron-Corwin, M., Passi, R., Chandel, A., Cooper, A., Abdelhamid, A. Tags: Fetus and Newborn Infant Articles Source Type: news
