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This page shows you the most recent publications within this specialty of the MedWorm directory.
Neonatal Resuscitation: Guidelines vs RealityNeonatal Resuscitation: Guidelines vs Reality
Strict adherence to the timing of neonatal resuscitation guidelines might be as unnecessary as it is impossible. Medscape Nurses (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 9, 2013 Category: Consumer Health News Tags: Nursing Viewpoint Source Type: news
Immersion in water in labour and birth.
CONCLUSIONS: Evidence suggests that water immersion during the first stage of labour reduces the use of epidural/spinal analgesia and duration of the first stage of labour. There is limited information for other outcomes related to water use during the first and second stages of labour, due to intervention and outcome variability. There is no evidence of increased adverse effects to the fetus/neonate or woman from labouring in water or waterbirth. However, the studies are very variable and considerable heterogeneity was detected for some outcomes. Further research is needed. PMID: 24310807 [PubMed - in process] (Source...
Source: Sao Paulo Medical Journal - December 9, 2013 Category: Journals (General) Authors: Cluett ER, Burns E Tags: Sao Paulo Med J Source Type: research
Prediction of sepsis-related outcomes in neonates through systematic genotyping of polymorphisms in genes for innate immunity and inflammation: a narrative review and critical perspective.
CONCLUSIONS: Sepsis prediction through systematic genotyping needs to be reevaluated, based on studies that demonstrate the functional impact of gene polymorphisms and epidemiological differences among ethnically distinct populations. PMID: 24310803 [PubMed - in process] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - December 9, 2013 Category: Journals (General) Authors: Carvalho JK, Moore DB, Luz RA, Xavier-Elsas PP, Gaspar-Elsas MI Tags: Sao Paulo Med J Source Type: research
Effect of ambulatory versus hospital treatment for gestational diabetes or hyperglycemia on infant mortality rates: a systematic review.
CONCLUSIONS: This review, based on studies with high or moderate risk of bias, showed that there was no statistically significant difference between ambulatory management and hospital care, regarding reduction of mortality rates in pregnancies complicated by diabetes or hyperglycemia. It also suggested that there is a need for further randomized controlled trials on this issue. PMID: 24310802 [PubMed - in process] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - December 9, 2013 Category: Journals (General) Authors: Rudge MV, Lima SA, El Dib RP, Marini G, Magalhães C, Calderon Ide M Tags: Sao Paulo Med J Source Type: research
Paediatric and Perinatal Epidemiology: State of the Journal
(Source: Paediatric and Perinatal Epidemiology)
Source: Paediatric and Perinatal Epidemiology - December 9, 2013 Category: Perinatology & Neonatology Tags: Editorial Source Type: research
An Appreciation to Our Unsung Heroes
(Source: Paediatric and Perinatal Epidemiology)
Source: Paediatric and Perinatal Epidemiology - December 9, 2013 Category: Perinatology & Neonatology Authors: Cande V. Ananth Tags: List of Reviewers Source Type: research
Neonatal head injury unrelated to birth trauma in South-East Nigeria - Uche EO, Emejulu JK, Ekenze SO, Okorie E, Uche NJ.
BACKGROUND: Neonatal head trauma resulting from causes other than birth trauma has rarely been the focus of many a research theme in the literature. AIM/OBJECTIVE: To highlight the occurrence of non-birth trauma related neonatal head injury, and evalua... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - December 8, 2013 Category: Global & Universal Tags: Age: Infants and Children Source Type: news
Animal models of anxiety disorders and stress.
Abstract Anxiety and stress-related disorders are severe psychiatric conditions that affect performance in daily tasks and represent a high cost to public health. The initial observation of Charles Darwin that animals and human beings share similar characteristics in the expression of emotion raise the possibility of studying the mechanisms of psychiatric disorders in other mammals (mainly rodents). The development of animal models of anxiety and stress has helped to identify the pharmacological mechanisms and potential clinical effects of several drugs. Animal models of anxiety are based on conflict situations tha...
Source: Revista Brasileira de Psiquiatria - December 8, 2013 Category: Psychiatry Authors: Campos AC, Fogaça MV, Aguiar DC, Guimarães FS Tags: Rev Bras Psiquiatr Source Type: research
A synopsis of recent influential papers published in psychiatric journals from the Arab world (2012).
Authors: Okasha T, Elkholy H Abstract This review includes six recent and influential papers that have appeared in the three leading psychiatry journals from the Arab region. The first paper examined the role of personality profile in the motivation to quit smoking and concluded that there is a positive correlation between Novelty seeking (NS), Persistence (P), Cooperativeness (C) and motivation to quit smoking. The second study discussed the prevalence of abuse history in patients with schizophrenia whether physical or sexual, and its impact on their condition and function. The third paper reported that patients w...
Source: Asian Journal of Psychiatry - December 7, 2013 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Spatial autocorrelation in uptake of antenatal care and relationship to individual, household and village-level factors: results from a community-based survey of pregnant women in six districts in western Kenya
Conclusions: ANC attendance was consistently low across all the districts, but factors related to poor attendance varied. This heterogeneity is expected for an outcome that is highly influenced by socio-cultural values and local context. Interventions to improve use of ANC must be tailored to local context and should include explicit approaches to reach women who work outside the home. (Source: International Journal of Health Geographics)
Source: International Journal of Health Geographics - December 7, 2013 Category: Global & Universal Authors: Wendy Prudhomme O¿MearaAlyssa PlattViolet NaanyuDonald ColeSamson Ndege Source Type: research
Pregnancy outcome after use of cranberry in pregnancy - the Norwegian mother and child cohort study
Background: Cranberry is one of the most commonly used herbs during pregnancy. The herb has been used traditionally against urinary tract infections. No studies are found that specifically address the risk of malformations after use of cranberry during pregnancy. The aim of the study was to investigate the safety of cranberry use during pregnancy, including any effects on congenital malformations and selected pregnancy outcomes. Methods: The study is based on data from The Norwegian Mother and Child Cohort Study including more than 100,000 pregnancies from 1999 to 2008. Information on use of cranberry and socio-demographic...
Source: BMC Complementary and Alternative Medicine - December 7, 2013 Category: Complementary Medicine Authors: Kristine HeitmannHedvig NordengLone Holst Source Type: research
Melatonin Prevents Experimental Preterm Labor And Increases Offspring Survival
This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - December 7, 2013 Category: Research Authors: Ana Paula Domínguez Rubio, Micaela Sordelli, Ana Inés Salazar, Julieta Aisemberg, María Victoria Bariani, Maximiliano Cella, Ruth E. Rosenstein, Ana María Franchi Tags: Original Article Source Type: research
Perinatal maternal stress and serotonin signaling: Effects on pain sensitivity in offspring
ABSTRACT It has been estimated that 20% of pregnant women are facing perinatal stress and depression. Perinatal maternal stress has been shown to increase pain sensitivity in offspring. For the treatment of their depressive symptoms, pregnant women are frequently prescribed selective serotonin reuptake inhibitors (SSRIs). Since the descending pain inhibitory circuit matures perinatally, perinatal SSRI exposure has been shown to affect pain sensitivity in offspring. In the present review, we summarize experimental and clinical evidence for the effect of perinatal maternal stress and SSRI exposure on pain sensitivity in offs...
Source: Developmental Psychobiology - December 6, 2013 Category: Psychiatry & Psychology Authors: Liesbeth Knaepen, Jodi L. Pawluski, Jacob Patijn, Maarten van Kleef, Dick Tibboel, Elbert A. Joosten Tags: Review Article Source Type: research
Reliability of an instrument to classify newborns according to care complexity
Na maioria das maternidades, a classificação, a avaliação e a definição da unidade a encaminhar o recém-nascido (RN) após o nascimento são realizadas pelo médico. A avaliação ocorre na sala de parto considerando: peso ao nascer; idade gestacional; condutas que definem quadro clínico e doença. Este estudo observacional teve como objetivo avaliar a confiabilidade de um instrumento de classificação de RN. A pesquisa foi realizada no berçário de um hospital público, São Paulo. Nove enfermeiras aplicaram o instrumento a 63 RN, sendo duas simultaneamente em cada um dos cinco setores do berçário. Verificou-s...
Source: Revista da Escola de Enfermagem da USP - December 6, 2013 Category: Nursing Source Type: research
Central venous catheterization in Pediatric and Neonatal Intensive Care Units
This study assessed the process of central venous catheterization with the aim of improving care provided to the neonatal and pediatric patients. (Source: Revista da Escola de Enfermagem da USP)
Source: Revista da Escola de Enfermagem da USP - December 6, 2013 Category: Nursing Source Type: research
Analgesia and sedation during placement of peripherally inserted central catheters in neonates
This study aimed to characterize the analgesia and sedation strategies in neonates having a peripherally inserted central catheter (PICC) placed, and to relate it to the number of venipunctures, duration of procedure and catheter tip position. This was a cross-sectional study with prospective data collection, conducted in a neonatal intensive care unit of a private hospital in the city of São Paulo, during the period from August 31, 2010 to July 1, 2011, which evaluated 254 PICC insertions. The adoption of analgesic or sedative strategies occurred in 88 (34.6%) catheter placements and was not related to the number of veni...
Source: Revista da Escola de Enfermagem da USP - December 6, 2013 Category: Nursing Source Type: research
Protein identified that helps developing germ cells wipe genes clean of past imprints
A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study by researchers at Boston Children's Hospital. This discovery could help provide clues to the cause of some kinds of neonatal growth defects and may also help advance the development of stem cell models of disease.The findings were reported online in Nature by a research team led by Yi Zhang, PhD, and Shinpei Yamaguchi, PhD, of Boston Children's Program in Cellular and Molecular Medicine. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 6, 2013 Category: Consumer Health News Tags: Genetics Source Type: news
[In Process Citation].
CONCLUSION: Women prefer to receive health services in their mother tongue, however services are delivered in English most of the time. Participants report that during times of stress and emergency, communication in French is essential to a quality follow-up of patients. Linguistic and cultural congruence seems to be a key factor for quality care during pregnancy. A comparative study would assist in better ascertaining the relative impact of language on Francophone women's lived experiences during pregnancy. PMID: 24300325 [PubMed - in process] (Source: Canadian Journal of Public Health)
Source: Canadian Journal of Public Health - December 6, 2013 Category: Global & Universal Authors: Lacaze-Masmonteil T, Leis A, Lauriol E, Normandeau J, Moreau D, Bouchard L, Vaillancourt C Tags: Can J Public Health Source Type: research
Distinctive population of Gfap‐expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus
ABSTRACT In the adult hippocampus, granule cells continue to be generated from astrocyte‐like progenitors expressing glial fibrillary acidic protein (GFAP) that differ from embryonic neocortical progenitors. However, during the embryonic period, dentate granule neurons and neocortical pyramidal neurons are derived from the ventricular zone (VZ) of the pallium. Our question is when do GFAP+ progenitors of granule neurons appear in the developing hippocampus during the embryonic period, and how do they form the granule cell layer. The present analysis using Gfap‐GFP transgenic mice shows that the GFP+ distinct cell popul...
Source: The Journal of Comparative Neurology - December 6, 2013 Category: Neurology Authors: Tatsunori Seki, Toru Sato, Keiko Toda, Noriko Osumi, Tetsuya Imura, Seiji Shioda Tags: Cover Image Source Type: research
Impact of the New 16-Hour Duty Period on Pediatric Interns' Neonatal Education
Conclusions. The decrease in duty hours was achieved without significantly affecting interns’ knowledge or clinical experience. (Source: Clinical Pediatrics)
Source: Clinical Pediatrics - December 6, 2013 Category: Pediatrics Authors: DeLaroche, A., Riggs, T., Maisels, M. J. Tags: Articles Source Type: research
Advances in Hirschsprung Disease Genetics and Treatment Strategies: An Update for the Primary Care Pediatrician
This article reviews current understanding of the etiology of HSCR, its multigenic associations, the historical evolution of HSCR diagnosis and treatment, and current HSCR therapies. (Source: Clinical Pediatrics)
Source: Clinical Pediatrics - December 6, 2013 Category: Pediatrics Authors: Burkardt, D. D., Graham, J. M., Short, S. S., Frykman, P. K. Tags: Articles Source Type: research
Emerging chronic non-communicable diseases in rural communities of Northern Ethiopia: evidence using population-based verbal autopsy method in Kilite Awlaelo surveillance site
Conclusion In the rural district, mortality due to chronic non-communicable diseases was very high. The observed magnitude of death from chronic non-communicable disease is unlikely to be unique to this district. Thus, formulation of chronic disease prevention and control strategies is recommended. (Source: Health Policy and Planning)
Source: Health Policy and Planning - December 6, 2013 Category: Health Management Authors: Weldearegawi, B., Ashebir, Y., Gebeye, E., Gebregziabiher, T., Yohannes, M., Mussa, S., Berhe, H., Abebe, Z. Tags: Original article Source Type: research
Effects of Isoform-selective PI3K Inhibitors on Osteoclasts [Cell Biology]
We examined effects of PI3K inhibitors on osteoclast survival. Whereas PIK75, TGX221, and GS-9820 had no significant effect on basal survival, all blocked RANKL-stimulated survival. When studied on resorbable substrates, osteoclastic resorption was suppressed by wortmannin and inhibitors of PI3Kβ and PI3Kδ, but not other isoforms. These data are consistent with a critical role for PI3Kδ in regulating osteoclast cytoskeleton and resorptive activity. In contrast, multiple PI3K isoforms contribute to the control of osteoclast survival. Thus, the PI3Kδ isoform, which is predominantly expressed in cells of hematopoietic ori...
Source: Journal of Biological Chemistry - December 6, 2013 Category: Chemistry Authors: Shugg, R. P. P., Thomson, A., Tanabe, N., Kashishian, A., Steiner, B. H., Puri, K. D., Pereverzev, A., Lannutti, B. J., Jirik, F. R., Dixon, S. J., Sims, S. M. Tags: Signal Transduction Source Type: research
Diagnostic delays in children with early onset epilepsy: Impact, reasons, and opportunities to improve care
We examined the frequency of diagnostic delays in young children with newly presenting epilepsy, their developmental impact, and reasons for delays. MethodsChildren who developed epilepsy before their third birthday were identified in a prospective community‐based cohort. An interval ≥1 month from second seizure to diagnosis was considered a delay. Testing of development at baseline and for up to 3 years after and of intelligence quotient (IQ) 8–9 years later was performed. Detailed parental baseline interview accounts and medical records were reviewed to identify potential reasons for delays. Factors associated w...
Source: Epilepsia - December 6, 2013 Category: Neurology Authors: Anne T. Berg, Tobias Loddenkemper, Christine B. Baca Tags: Full‐Length Original Research Source Type: research
Abstract James Sidman, MD, and Sherard A. Tatum, MD, address the following questions for discussion and debate. Is neonatal distraction osteogenesis (DO) better than lip-tongue adhesion or tracheotomy for micrognathic airway compromise? What role does DO have in adult orthognathic surgery situations? In monobloc and Le Fort III procedures, are internal or external devices preferable? What role does DO play in craniofacial microsomia? Is endoscopic DO better than open procedures for synostosis management? How has your technique changed or evolved over the past 5 years and what has doing this technique taught you? ...
Source: The Surgical Clinics of North America - December 5, 2013 Category: Surgery Authors: Sidman J, Tatum SA Tags: Facial Plast Surg Clin North Am Source Type: research
Mother-to-be and her unborn baby died at maternity unit after doctors took six hours to decide the best treatment for her premature labour
The family of hairdresser Carly Harper, 24, claim she died when five months pregnant thanks to negligence by staff at Arrowe Park Hospital, Merseyside. (Source: the Mail online | Health)
Source: the Mail online | Health - December 5, 2013 Category: Consumer Health News Source Type: news
Comment on “On gestational weeks and maths”
(Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - December 5, 2013 Category: Perinatology & Neonatology Authors: Pieter Hummel Tags: Correspondence Source Type: research
Response to “On gestational weeks and maths”
(Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - December 5, 2013 Category: Perinatology & Neonatology Authors: Peter Benn, Antoni Borrell, Rossa Chiu, Howard Cuckle, Lorraine Dugoff, Brigitte Faas, Susan Gross, Joann Johnson, Ron Maymon, Mary Norton, Anthony Odibo, Peter Schielen, Kevin Spencer, Tianhua Huang, Dave Wright, Yuval Yaron Tags: Correspondence Source Type: research
Neonatal Bee Venom Exposure Induces Sensory Modality‐Specific Enhancement of Nociceptive Response in Adult Rats
ConclusionThese results indicate that neonatal inflammation produces sensory modality‐specific changes in nociceptive behavior and alters neurochemistry in the spinal cord of adult rats. These results also suggest that a prior history of inflammatory pain during the developmental period might have an impact on clinical pain in highly susceptible adult patients. (Source: Pain Medicine)
Source: Pain Medicine - December 5, 2013 Category: Anesthesiology Authors: Mengmeng Li, Huisheng Chen, Jiaguang Tang, Jun Chen Tags: Original Article Source Type: research
Molecular epidemiology of coagulase-negative Staphylococcus carriage in neonates admitted to an intensive care unit in Brazil
Conclusions: NICU represents an environment of risk for colonization by MDR CoNS. Neonates admitted to the NICU can become a reservoir of CoNS strains with the potential to spread MDR strains into the community. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - December 5, 2013 Category: Infectious Diseases Authors: Yves TernesJuliana Lamaro-CardosoMaria AndréVicente PessoaMaria VieiraRuth MinamisavaAna AndradeAndré Kipnis Source Type: research
Duration and urgency of transfer in births planned at home and in freestanding midwifery units in England: secondary analysis of the birthplace national prospective cohort study
Conclusions: Transfers from home or FMU commonly take up to 60 minutes from decision to transfer, to first assessment in an OU, even for transfers for potentially urgent reasons. Most transfers are not urgent and emergencies and adverse outcomes are uncommon, but urgent transfer is more likely for nulliparous women. (Source: BMC Pregnancy and Childbirth - Latest articles)
Source: BMC Pregnancy and Childbirth - Latest articles - December 5, 2013 Category: OBGYN Authors: Rachel RoweJohn TownendPeter BrocklehurstMarian KnightAlison MacfarlaneChristine McCourtMary NewburnMaggie RedshawJane SandallLouise SilvertonJennifer Hollowell Source Type: research
Risk determinants in early intervention use during the first postnatal year in children born very preterm
This study examined the risk determinants of EI in Australian children born less than 32 weeks gestation during the first year of life. Methods: As part of a multi-centre-randomised-trial, 195 children were prospectively studied during their first year of life and EI use, type of follow-up, perinatal, social and parental psychosocial risk factors were collected using questionnaires. Child neurodevelopmental disability-status was assessed at 12-months (cerebral palsy, blind, deaf, developmental quotient 1standard deviation (SD) below mean). The associations between EI and variables were examined using Pearson's chi-squared ...
Source: BMC Pediatrics - Latest articles - December 5, 2013 Category: Pediatrics Authors: Margo PritchardPaul ColditzDavid CartwrightPeter GrayDavid TudehopeElaine Beller Source Type: research
Small mosaic deletion encompassing the snoRNAs and SNURF‐SNRPN results in an atypical Prader–Willi syndrome phenotype
Abstract Genetic analyses were performed in a male patient with suspected Prader–Willi syndrome who presented with hypogonadism, excessive eating, central obesity, small hands and feet and cognition within the low normal range. However, he had no neonatal hypotonia or feeding problems during infancy. Chromosome analysis showed a normal male karyotype. Further analysis with array‐CGH identified a mosaic 847 kb deletion in 15q11‐q13, including SNURF‐SNRPN, the snoRNA gene clusters SNORD116 (HBII‐85), SNORD115, (HBII‐52), SNORD109 A and B (HBII‐438A and B), SNORD64 (HBII‐13), and NPAP1 (C15ORF2). MLPA confir...
Source: American Journal of Medical Genetics Part A - December 5, 2013 Category: Genetics & Stem Cells Authors: Britt‐Marie Anderlid, Johanna Lundin, Helena Malmgren, Mikael Lehtihet, Ann Nordgren Tags: Research Article Source Type: research
Our children are not a diagnosis: The experience of parents who continue their pregnancy after a prenatal diagnosis of trisomy 13 or 18
Trisomy 13 and trisomy 18 (T13‐18) are associated with high rates of perinatal death and with severe disability among survivors. Prenatal diagnosis (PND) may lead many women to terminate their pregnancy but some women choose to continue their pregnancy. We sent 503 invitations to answer a questionnaire to parents who belong to T13 and 18 internet support groups. Using mixed methods, we asked parents about their prenatal experience, their hopes, the life of their affected child, and their family experience. 332 parents answered questions about 272 children; 128 experienced PND. These parents, despite feeling pressure to t...
Source: American Journal of Medical Genetics Part A - December 5, 2013 Category: Genetics & Stem Cells Authors: Jennifer Guon, Benjamin S. Wilfond, Barbara Farlow, Tracy Brazg, Annie Janvier Tags: Research Article Source Type: research
A case of pancreatic agenesis and congenital heart defects with a novel GATA6 nonsense mutation: Evidence of haploinsufficiency due to nonsense‐mediated mRNA decay
The objective of this study was to perform a genetic analysis of a patient with PACHD. A female patient presented with ventricular septal defect, patent ductus arteriosus, and congenital diaphragmatic hernia at birth. Permanent neonatal diabetes mellitus and pancreatic exocrine deficiency due to pancreatic agenesis was diagnosed at 1 month of age. PCR‐direct sequencing of GATA6 revealed that the patient is heterozygous for a novel de novo nonsense mutation of c.1477C>T, p. Arg493X in exon 5. RT‐PCR direct sequencing of the RT‐PCR products of total RNA from peripheral blood of the patient for the region encompassin...
Source: American Journal of Medical Genetics Part A - December 5, 2013 Category: Genetics & Stem Cells Authors: Shigeru Suzuki, Atsushi Nakao, Ashoor R. Sarhat, Akiko Furuya, Kumihiro Matsuo, Yusuke Tanahashi, Hiroki Kajino, Hiroshi Azuma Tags: Clinical Report Source Type: research
A compound heterozygous mutation in HADHB gene causes an axonal Charcot-Marie-tooth disease
Conclusions: These data implicate that mutation in HADHB gene can also cause early-onset axonal CMT instead of typical manifestations in mitochondrial trifunctional protein (MTP) deficiency. Therefore, this study is the first report of a new subtype of autosomal recessive axonal CMT by a compound heterozygous mutation in HADHB, and will expand the clinical and genetic spectrum of HADHB. (Source: BMC Medical Genetics - Latest articles)
Source: BMC Medical Genetics - Latest articles - December 5, 2013 Category: Genetics & Stem Cells Authors: Young HongJa LeeJin-Mo ParkYu-Ri ChoiYoung HyunBo YoonJeong YooHeasoo KooSung-Chul JungKi ChungByung-Ok Choi Source Type: research
α1 adrenoceptor activation by norepinephrine inhibits LPS‐induced cardiomyocyte TNF‐α production via modulating ERK1/2 and NF‐κB pathway
This study was designed to observe the effect of norepinephrine (NE) on lipopolysaccharide (LPS)‐induced cardiomyocyte TNF‐α expression and to further investigate the underlying mechanisms in neonatal rat cardiomyocytes and endotoxaemic mice. In cultured neonatal rat cardiomyocytes, NE inhibited LPS‐induced TNF‐α production in a dose‐dependent manner. α1‐ adrenoceptor (AR) antagonist (prazosin), but neither β1‐ nor β2‐AR antagonist, abrogated the inhibitory effect of NE on LPS‐stimulated TNF‐α production. Furthermore, phenylephrine (PE), an α1‐AR agonist, also suppressed LPS‐induced TNF‐α ...
Source: Journal of Cellular and Molecular Medicine - December 5, 2013 Category: Molecular Biology Authors: Xiaohui Yu, Baoyin Jia, Faqiang Wang, Xiuxiu Lv, Xuemei Peng, Yiyang Wang, Hongmei Li, Yanping Wang, Daxiang Lu, Huadong Wang Tags: Original Article Source Type: research
Fetal iron deficiency alters the proteome of adult rat hippocampal synaptosomes
Fetal and neonatal iron deficiency results in cognitive impairments in adulthood despite prompt postnatal iron replenishment. To systematically determine whether abnormal expression and localization of proteins that regulate adult synaptic efficacy are involved, we used a quantitative proteomic approach (isobaric tags for relative and absolute quantitation, iTRAQ) and pathway analysis to identify dysregulated proteins in hippocampal synapses of fetal iron deficiency model. Rat pups were made iron deficient (ID) from gestational day 2 through postnatal day (P) 7 by providing pregnant and nursing dams an ID diet (4 ppm Fe) a...
Source: AJP: Regulatory, Integrative and Comparative Physiology - December 5, 2013 Category: Physiology Authors: Tran, P. V., Dakoji, S., Reise, K. H., Storey, K. K., Georgieff, M. K. Tags: Translational Physiology Source Type: research
Does multiple gestation impact birthweight deficit from smoking?
Does multiple gestation impact birthweight deficit from smoking? Journal of Perinatology advance online publication, December 5 2013. doi:10.1038/jp.2013.148 Authors: F A Okah, A A Oshodi, Y Liu & J Cai (Source: Journal of Perinatology)
Source: Journal of Perinatology - December 5, 2013 Category: Perinatology & Neonatology Authors: F A OkahA A OshodiY LiuJ Cai Tags: smoking growth restriction twin pregnancy Source Type: research
Frequency-modulated orocutaneous stimulation promotes non-nutritive suck development in preterm infants with respiratory distress syndrome or chronic lung disease
e & D Thompson (Source: Journal of Perinatology)
Source: Journal of Perinatology - December 5, 2013 Category: Perinatology & Neonatology Authors: S M BarlowJ LeeJ WangA OderS HallK KnoxK WeatherstoneD Thompson Tags: suck central pattern generator sensory experience mechanosensory experience orofacial NNS critical period Source Type: research
Amplitude-integrated EEG and range-EEG modulation associated with pneumatic orocutaneous stimulation in preterm infants
Oder & D Song (Source: Journal of Perinatology)
Source: Journal of Perinatology - December 5, 2013 Category: Perinatology & Neonatology Authors: S M BarlowP JegatheesanS WeissB GovindaswamiJ WangJ LeeA OderD Song Tags: somatosensory orofacial brain prematurity electroencephalography experience dependent Source Type: research
Is variation in total antioxidant capacity of human milk associated with levels of bio-active proteins?
Is variation in total antioxidant capacity of human milk associated with levels of bio-active proteins? Journal of Perinatology advance online publication, December 5 2013. doi:10.1038/jp.2013.151 Authors: R Mehta & A Petrova (Source: Journal of Perinatology)
Source: Journal of Perinatology - December 5, 2013 Category: Perinatology & Neonatology Authors: R MehtaA Petrova Tags: human milk preterm-born infants bio-active proteins total antioxidant capacity Source Type: research
Hoxa5/Cre transgenic mice: novel tools for regional deletion along the anterior‐posterior axis
ABSTRACT The Hoxa5 homeobox gene encodes a transcription factor that plays a critical role in specifying the identity of the cervico‐thoracic region along the anterior‐posterior embryo axis and in orchestrating organ morphogenesis. The loss of Hoxa5 function results in skeletal transformations, lethality at birth due to lung defects, and organ anomalies affecting the digestive tract, the mammary gland and the ovary. Study of Hoxa5 gene regulation has revealed the interplay of several control regions that direct Hoxa5 developmental expression. Enhancers targeting expression in the CNS, the paraxial and lateral plate mes...
Source: genesis - December 5, 2013 Category: Genetics & Stem Cells Authors: Félix‐Antoine Bérubé‐Simard, Lucie Jeannotte Tags: Technology Report Source Type: research
Association of Fentanyl With Neurodevelopmental Outcomes in Very-Low-Birth-Weight Infants.
CONCLUSIONS: When controlling for other variables, the cumulative fentanyl dose did not correlate with neurodevelopmental outcomes. Further evaluation of benefits and risks of opioids in premature infants are needed. PMID: 24311724 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - December 5, 2013 Category: Drugs & Pharmacology Authors: Lammers EM, Johnson PN, Ernst KD, Hagemann TM, Lawrence SM, Williams PK, Anderson MP, Miller JL Tags: Ann Pharmacother Source Type: research
Prophylactic antibiotics for inhibiting preterm labour with intact membranes.
CONCLUSIONS: This review did not demonstrate any benefit in important neonatal outcomes with the use of prophylactic antibiotics for women in preterm labour with intact membranes, although maternal infection may be reduced. Of concern, is the finding of short- and longer-term harm for children of mothers exposed to antibiotics. The evidence supports not giving antibiotics routinely to women in preterm labour with intact membranes in the absence of overt signs of infection.Further research is required to develop sensitive markers of subclinical infection for women in preterm labour with intact membranes, as this is a group ...
Source: Cochrane Database of Systematic Reviews - December 5, 2013 Category: Journals (General) Authors: Flenady V, Hawley G, Stock OM, Kenyon S, Badawi N Tags: Cochrane Database Syst Rev Source Type: research
Women's Perceptions of Breastfeeding Barriers in Early Postpartum Period: A Qualitative Analysis Nested in Two Randomized Controlled Trials
Breastfeeding Medicine , Vol. 0, No. 0. (Source: Breastfeeding Medicine)
Source: Breastfeeding Medicine - December 4, 2013 Category: Perinatology & Neonatology Tags: article Source Type: research
[Genetic, environmental, and epigenetic contribution to the susceptibility to autism spectrum disorders].
CONCLUSIONS. There is genetic heterogeneity and probably different modes of transmission in ASD. In addition, many cases are related with non-inherited de novo mutations or uncommon alleles with a large effect. The general heritability in these disorders may be lower than previously reported. Some fraction of it may be explained by relatively common alleles that tend to have a small effect. To some extent, susceptibility alleles may have a different influence on the phenotype depending on other genetic or non-genetic factors. Non-genetic factors in the perinatal and postnatal period, including epigenetics, the age of the f...
Source: Revista de Neurologia - December 4, 2013 Category: Neurology Authors: Diaz-Anzaldua A, Diaz-Martinez A Tags: Rev Neurol Source Type: research