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This page shows you the most recent publications within this specialty of the MedWorm directory.

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(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - November 20, 2014 Category: Perinatology & Neonatology Source Type: research

Table of Contents
(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - November 20, 2014 Category: Perinatology & Neonatology Source Type: research

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(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - November 20, 2014 Category: Perinatology & Neonatology Source Type: research

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(Source: Seminars in Perinatology)
Source: Seminars in Perinatology - November 20, 2014 Category: Perinatology & Neonatology Source Type: research

Effects of maternal bisphosphonate use on fetal and neonatal outcomes.
CONCLUSION: A limited body of published data suggests that maternal use of bisphosphonates before or during pregnancy does not have serious fetal or neonatal adverse effects. PMID: 25404594 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2014 Category: Drugs & Pharmacology Authors: Green SB, Pappas AL Tags: Am J Health Syst Pharm Source Type: research

Genome-wide and candidate gene association studies of placental abruption.
Authors: Workalemahu T, Enquobahrie DA, Moore A, Sanchez SE, Ananth CV, Pacora PN, Liang L, Salazar M, Williams MA Abstract Placental abruption (PA), a pregnancy-related vascular disorder, is a leading cause of maternal and perinatal morbidity and mortality. The success of identifying genetic susceptibility loci for PA, a multi-factorial heritable disorder, has been limited. We conducted a genome-wide association study (GWAS) and candidate gene association study using 470 PA cases and 473 controls from Lima, Peru. Genotyping for common genetic variations (single nucleotide polymorphisms, SNPs) was conducted using t...
Source: International Journal of Molecular Epidemiology and Genetics - November 20, 2014 Category: Genetics & Stem Cells Tags: Int J Mol Epidemiol Genet Source Type: research

The clinical spectrum of inherited diseases involved in the synthesis and remodeling of complex lipids. A tentative overview
Abstract Over one hundred diseases related to inherited defects of complex lipids synthesis and remodeling are now reported. Most of them were described within the last 5 years. New descriptions and phenotypes are expanding rapidly. While the associated clinical phenotype is currently difficult to outline, with only a few patients identified, it appears that all organs and systems may be affected. The main clinical presentations can be divided into (1) Diseases affecting the central and peripheral nervous system. Complex lipid synthesis disorders produce prominent motor manifestations due to upper and/or lower mo...
Source: Journal of Inherited Metabolic Disease - November 20, 2014 Category: Internal Medicine Source Type: research

Assessment of Neonatal Hyperbilirubinemia Using GEM Premier 4000 Total Bilirubin Assay: Impact on Risk Classification?
In this study, we evaluated the correlation of whole blood TBili results measured on a blood gas analyzer to serum results obtained on an automated chemistry analyzer. In addition, we determined the concordance of hyperbilirubinemia risk classification between the 2 methods. Seventy-nine blood samples were collected. The TBili (mg/dL) was measured on whole blood using the Instrumentation Laboratories GEM 4000 (GEM) and on simultaneously collected serum samples on the Siemens Dimension Vista chemistry analyzer (Vista). Twenty-four infants, aged younger than 7 days, were classified into categories for risk of sequelae of sev...
Source: Point of Care: The Journal of Near-Patient Testing and Technology - November 20, 2014 Category: Pathology Tags: Original Articles Source Type: research

Decolonization to Prevent S. aureus Infections in the NICUDecolonization to Prevent S. aureus Infections in the NICU
Is targeted decolonization an effective method to prevent S. aureus infections in the NICU? Journal of Perinatology : Official Journal of the California Perinatal Association (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 20, 2014 Category: Consumer Health News Tags: Pediatrics Journal Article Source Type: news

Cardiopulmonary arrest in pregnancy with schizophrenia: a case report
Conclusion: We speculate that the cause of cardiopulmonary arrest was aspiration due to seizure, and it is possible that a neurological response was evoked by administration of antipsychotic drugs and/or by eclampsia. Medical staff must be aware of the possibility of cardiopulmonary arrest in pregnant women with schizophrenia. (Source: BioMed Central)
Source: BioMed Central - November 20, 2014 Category: Journals (General) Authors: Takako KudoAkimune KagaKozo AkagiHideki IwahashiHiromitsu MakinoYoko WatanabeTakae KawamuraTaiju SatoTsuyoshi ShinozakiShinya MiwaNobuo OkazakiShigeo KureShingi Nakae Source Type: research

Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions
Conclusions These results indicate that maternal betaine supplementation enhances betaine/methionine metabolism and DNA methyltransferase expression, causes hypermethylation of DMR on IGF2 gene, which was associated with augmented expression of IGF2 and cell proliferation/anti-apoptotic markers in the hippocampus of neonatal piglets. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - November 20, 2014 Category: Nutrition Source Type: research

Team training in obstetric and neonatal emergencies using highly realistic simulation in Mexico: impact on process indicators
This report assesses the impact of PRONTO simulation training on process indicators from the pre/post study design for process indicators. Methods: Data was collected in twelve intervention facilities on process indicators, including pre/post changes in knowledge and self-efficacy of obstetric emergencies and neonatal resuscitation, achievement of strategic planning goals established during training and changes in teamwork scores. Authors performed a longitudinal fixed-effects linear regression model to estimate changes in knowledge and self-efficacy and logistic regression to assess goal achievement. Results: A total of 4...
Source: BMC Pregnancy and Childbirth - November 20, 2014 Category: OBGYN Authors: Dilys WalkerSusanna CohenJimena FritzMarisela OlveraHector Lamadrid-FigueroaJessica CowanDolores HernandezJulia DettingerJenifer Fahey Source Type: research

Letter From the Guest Editor: Neonatal Imaging—Part 1
Publication date: December 2014 Source:Seminars in Ultrasound, CT and MRI, Volume 35, Issue 6 Author(s): Beverley Newman (Source: Seminars in Ultrasound, CT and MRI)
Source: Seminars in Ultrasound, CT and MRI - November 20, 2014 Category: Radiology Source Type: research

Disparities in antidepressant use in pregnancy
H Burris (Source: Journal of Perinatology)
Source: Journal of Perinatology - November 20, 2014 Category: Perinatology & Neonatology Authors: A YamamotoM C McCormickH H Burris Source Type: research

Enhanced Survival During Experimental Listeria monocytogenes Sepsis in Neonatal Mice Prophylactically Treated With Th1 and Macrophage Immunoregulatory Cytokines and Mediators
Conclusions:These data suggest prophylactic administration of macrophage and Th1 immunoregulatory cytokines can potentially overcome deficits in neonatal immunity to protect against Lm. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - November 19, 2014 Category: Infectious Diseases Tags: Immunology Reports Source Type: research

Factors Associated with Intrapartum Transmission of Group B Streptococcus
Background:Data regarding the minimum duration of intrapartum antibiotic prophylaxis (IAP) required for preventing group B Streptococcus (GBS) early-onset sepsis are conflicting. Understanding factors that influence neonatal colonization (NC) might help us understand factors associated with failure of prophylaxis. Methods:This is a 14-month prospective cohort study conducted at a single tertiary care center with a screening-based strategy. Women were enrolled if they had ≥35 weeks’ gestation and were GBS-positive at the vaginal site on admission. Their neonates were cultured from the throat and rectum at 24–48 h afte...
Source: The Pediatric Infectious Disease Journal - November 19, 2014 Category: Infectious Diseases Tags: Original Studies Source Type: research

Fetal, Perinatal Mortality Rates Stay Largely Unchanged in USFetal, Perinatal Mortality Rates Stay Largely Unchanged in US
Fetal and perinatal mortality rates stayed mostly stable during 2006-2012, but the perinatal rate was down 8% for non-Hispanic black women from 2006-2011. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 19, 2014 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

Type 1 diabetes, diabetic nephropathy, and pregnancy: a systematic review and meta-study.
CONCLUSIONS: The heterogeneous evidence from studies on diabetic nephropathy in pregnancy emphasizes the need for further perspective studies on this issue. PMID: 24172695 [PubMed - indexed for MEDLINE] (Source: Review of Diabetic Studies)
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Impact of gestational diabetes mellitus and high maternal weight on the development of diabetes, hypertension and cardiovascular disease: a population‐level analysis
ConclusionsNot surprisingly, the presence of both high maternal weight and GDM compounds the risk of developing diabetes. However, the association between overweight alone and GDM alone and hypertension and cardiovascular disease appears similar suggesting a need for effective interventions to manage both these conditions to improve the health of these patients.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)
Source: Diabetic Medicine - November 19, 2014 Category: Endocrinology Authors: P. Kaul, A. Savu, K. A. Nerenberg, L. E. Donovan, C. L. Chik, E. A. Ryan, J. A. Johnson Tags: Research Article Source Type: research

Equipotent Subanesthetic Concentrations of Sevoflurane and Xenon Preventing Cold-stimulated Vocalization of Neonatal Rats
Conclusions: The authors report equipotent subanesthetic concentrations of sevoflurane and xenon in neonatal rats with preserved cardiopulmonary function. This may be useful in designing neonatal rodent models of anesthesia. (Source: Anesthesiology)
Source: Anesthesiology - November 19, 2014 Category: Anesthesiology Tags: Perioperative Medicine: Basic Science Source Type: research

Clinical, laboratory, and therapeutic analyses of 21 patients with neonatal thrombosis and antiphospholipid antibodies: a literature review.
CONCLUSION: Neonatal thrombosis and antiphospholipid antibodies are rare. The development of thrombotic manifestations in neonates seems not to be associated exclusively with the aPL, but their etiology may be linked to pre- and perinatal events. We noted good therapeutic responses, especially in stroke patients, who presented with favorable outcomes in 82% of the cases. PMID: 25133197 [PubMed - in process] (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - November 19, 2014 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Relationship between maternal immunological response during pregnancy and onset of preeclampsia.
Authors: Martínez-Varea A, Pellicer B, Perales-Marín A, Pellicer A Abstract Maternofetal immune tolerance is essential to maintain pregnancy. The maternal immunological tolerance to the semiallogeneic fetus becomes greater in egg donation pregnancies with unrelated donors as the complete fetal genome is allogeneic to the mother. Instead of being rejected, the allogeneic fetus is tolerated by the pregnant woman in egg donation pregnancies. It has been reported that maternal morbidity during egg donation pregnancies is higher as compared with spontaneous or in vitro fertilization pregnancies. Particularly, egg dona...
Source: Journal of Immunology Research - November 19, 2014 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Cell-based therapies for the preterm infant
Publication date: December 2014 Source:Cytotherapy, Volume 16, Issue 12 Author(s): Dandan Zhu , Euan M. Wallace , Rebecca Lim The severely preterm infant receives a multitude of life-saving interventions, many of which carry risks of serious side effects. Cell therapy is an important and promising arm of regenerative medicine that may address a number of these problems. Most forms of cellular therapy use stem/progenitor cells or stem-like cells, which have the capacity to migrate, engraft and exert anti-inflammatory effects. Although some of these cell-based therapies have made their way to clinical trials in adults, lit...
Source: Cytotherapy - November 19, 2014 Category: Cytology Source Type: research

Interleukin-22: Biomarker of maternal and fetal inflammation?
Abstract Histologic chorioamnionitis (HCA) is an intrauterine status of inflammation which may lead to the fetal inflammatory response syndrome. Inflammation is a pathogenetic mechanism also of preeclampsia, although not of microbial origin. The aim of the present pilot study was to evaluate the pattern of inflammatory cytokines in mothers and high-risk preterm infants during the perinatal period. Concentrations of proinflammatory and anti-inflammatory cytokines and C-reactive protein were evaluated in maternal, cord, and neonatal blood of very preterm infants <1,500 g birth weight. Histologic examinations of ...
Source: Immunologic Research - November 19, 2014 Category: Allergy & Immunology Source Type: research

Composition qualitative de la flore fongique de l’environnement de 07 services à risque d’infections fongiques au CHU Aristide Le Dantec (Dakar)
Conclusion – Cette étude démontre que les espèces fongiques susceptibles de provoquer des infections fongiques nosocomiales sont présentes dans les services hébergeant les patients à RIF et que la surveillance des fongiques doit être inclus dans le programme des comités de lutte contre les infections nosocomiales (CLIN). Introduction – In hospitals, the quality control of the air is a key element. Indeed airborne fungi constitute a real danger for patients hospitalized in the risk of nosocomial infections especially in immunocompromised. Objectives – The objective was to determine the qualitative fungal flo...
Source: Journal of Medical Mycology - November 19, 2014 Category: Infectious Diseases Source Type: research

Adult-onset autosomal dominant centronuclear myopathy due to BIN1 mutations
In conclusion, we identified BIN1 as the second gene for dominant centronuclear myopathy. Our data provide the evidence that specific BIN1 mutations can cause either recessive or dominant centronuclear myopathy and that both disorders involve different pathomechanisms. (Source: Brain)
Source: Brain - November 19, 2014 Category: Neurology Authors: Bohm, J., Biancalana, V., Malfatti, E., Dondaine, N., Koch, C., Vasli, N., Kress, W., Strittmatter, M., Taratuto, A. L., Gonorazky, H., Laforet, P., Maisonobe, T., Olive, M., Gonzalez-Mera, L., Fardeau, M., Carriere, N., Clavelou, P., Eymard, B., Bitoun, Tags: Original Articles Source Type: research

Benefits of probiotics on enteral nutrition in preterm neonates: a systematic review [Nutritional epidemiology and public health]
Conclusions: Probiotics reduced the time to full enteral feeds in preterm neonates. Additional research is necessary to assess the optimal dose, duration, and probiotic strain or strains used specifically for facilitating enteral nutrition in this population. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - November 19, 2014 Category: Nutrition Authors: Athalye-Jape, G., Deshpande, G., Rao, S., Patole, S. Tags: Nutritional epidemiology and public health Source Type: research

Early Supplementation of Phospholipids and Gangliosides Affects Brain and Cognitive Development in Neonatal Piglets [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]
Conclusion: In summary, dietary phospholipids and gangliosides improved spatial learning and affected brain growth and composition in neonatal piglets. (Source: Journal of Nutrition)
Source: Journal of Nutrition - November 19, 2014 Category: Nutrition Authors: Liu, H., Radlowski, E. C., Conrad, M. S., Li, Y., Dilger, R. N., Johnson, R. W. Tags: Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions Source Type: research

Parenteral Nutrition Compromises Neurodevelopment of Preterm Pigs [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]
Conclusions: The compromised neurodevelopment caused by total PN is a novel finding, was independent of confounding variables (disease, inconsistent gestational ages, diverse genetics, extrauterine growth retardation, and inconsistent neonatal intensive care unit protocols), and highlights a need to improve current PN solutions. The preterm pig is a translational animal model for improving nutrition support to enhance neurodevelopment of preterm infants requiring PN. (Source: Journal of Nutrition)
Source: Journal of Nutrition - November 19, 2014 Category: Nutrition Authors: Choudhri, A. F., Sable, H. J., Chizhikov, V. V., Buddington, K. K., Buddington, R. K. Tags: Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions Source Type: research

Dietary Calcium Deficiency and Excess Both Impact Bone Development and Mesenchymal Stem Cell Lineage Priming in Neonatal Piglets [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]
Conclusions: Neonatal calcium deficiency appears to reduce the osteogenic priming of MSCs while enlarging a subpopulation of potentially adipogenic cells, and excess dietary calcium appears to allow greater multipotency of MSCs. These programming alterations of MSCs could have long-term consequences for bone health. (Source: Journal of Nutrition)
Source: Journal of Nutrition - November 19, 2014 Category: Nutrition Authors: Li, Y., Stahl, C. H. Tags: Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions Source Type: research

Prevention of Early Postnatal Hyperalimentation Protects against Activation of Transforming Growth Factor-{beta}/Bone Morphogenetic Protein and Interleukin-6 Signaling in Rat Lungs after Intrauterine Growth Restriction [Nutrition and Disease]
Conclusions: This study demonstrates a dual mechanism in IUGR-associated lung disease that is 1) IUGR-dependent and 2) HA-mediated and thereby offers new avenues to develop innovative preventive strategies for perinatal programming of adult lung diseases. (Source: Journal of Nutrition)
Source: Journal of Nutrition - November 19, 2014 Category: Nutrition Authors: Alejandre Alcazar, M. A., Dinger, K., Rother, E., Ostreicher, I., Vohlen, C., Plank, C., Dotsch, J. Tags: Nutrition and Disease Source Type: research

Dietary Vitamin D during Pregnancy Has Dose-Dependent Effects on Long Bone Density and Architecture in Guinea Pig Offspring but Not the Sows [Nutrient Requirements and Optimal Nutrition]
Conclusions: Maternal vitamin D supplementation dose-dependently altered pup long bone architecture and mineral density in a manner similar to vitamin D deficient rickets whereas maternal bone was stable. These data reinforce that inadequate maternal vitamin D intake may compromise neonatal bone health and that exceeding recommendations is not advantageous. (Source: Journal of Nutrition)
Source: Journal of Nutrition - November 19, 2014 Category: Nutrition Authors: Tabatabaei, N., Rodd, C. J., Kremer, R., Khavandgar, Z., Murshed, M., Weiler, H. A. Tags: Nutrient Requirements and Optimal Nutrition Source Type: research

High Vitamin D Status before Conception, but Not during Pregnancy, Is Inversely Associated with Maternal Gestational Diabetes Mellitus in Guinea Pigs [Nutrient Requirements and Optimal Nutrition]
Conclusions: Dietary vitamin D intake during pregnancy in guinea pigs does not affect the already high rate of GDM, whereas higher prepregnancy vitamin D status appears to be protective. (Source: Journal of Nutrition)
Source: Journal of Nutrition - November 19, 2014 Category: Nutrition Authors: Tabatabaei, N., Rodd, C. J., Kremer, R., Weiler, H. A. Tags: Nutrient Requirements and Optimal Nutrition Source Type: research

A protocol to identify non-classical risk factors for preterm births: the Brazilian Ribeirao Preto and Sao Luis prenatal cohort (BRISA)
Conclusion: Psychosocial, genetic and infectious mechanisms will be selected, since there are indications that they influence preterm birth (PTB). The studies will be conducted in two Brazilian cities with discrepant socioeconomic conditions. The expectation is to identify risk factors for PTB having a greater predictive power than classically studied factors. The final objective is to propose more effective interventions for the reduction of PTB, which, after being tested, might subsidize health policies. (Source: Reproductive Health)
Source: Reproductive Health - November 19, 2014 Category: OBGYN Authors: Antônio da SilvaVanda SimõesMarco BarbieriViviane CardosoClaudia AlvesErika ThomazRejane QueirozRicardo CavalliRosângela BatistaHeloísa Bettiol Source Type: research

Neonatal outcome and delivery mode in labours with repetitive fetal scalp blood sampling
To investigate if repeat (≥3) fetal scalp blood sampling (FBS) is associated with increased risk of caesarean delivery and worse neonatal outcome than occasional (1-2) FBS. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 19, 2014 Category: OBGYN Authors: Malin Holzmann, Stina Wretler, Sven Cnattingius, Lennart Nordström Source Type: research

Female obesity and infertility
Publication date: Available online 7 November 2014 Source:Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology Author(s): Alon Talmor , Bruce Dunphy Infertility affects 1 in 7 couples and the rate of this is on the increase. Ovulatory defects and unexplained causes account for over 50% of infertile aetiologies. It is postulated that a significant proportion of these cases are either directly or indirectly related to obesity. The prevalence of overweight and obese men and women has topped 50% in some developed countries. Obesity is on the increase worldwide; with that, the consequences in terms of as...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

Pregnancy after liver transplantation
Publication date: November 2014 Source:Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology, Volume 28, Issue 8 Author(s): Carlo B. Ramirez , Cataldo Doria Women constitute &gt;30% of patients undergoing liver transplantation (orthotopic liver transplantation, OLT) and about 8% are of reproductive age, and 5% are pediatric females who will mostly survive into adulthood and will consider pregnancy. Although pregnancy in OLT recipients is associated with an increased incidence of hypertension, preeclampsia, anemia, preterm deliveries, and cesarean section, acute rejection and liver allograft loss ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

Pregnancy after heart and lung transplantation
Publication date: November 2014 Source:Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology, Volume 28, Issue 8 Author(s): Robin Vos , David Ruttens , Stijn E. Verleden , Elly Vandermeulen , Hannelore Bellon , Bart M. Vanaudenaerde , Geert M. Verleden Patients awaiting transplantation should be counseled regarding posttransplant contraception and the potential adverse outcomes associated with posttransplant conception. Pregnancy should be avoided for at least 1–2 years post transplant to minimize the risks to allograft function and fetal well-being. Transplant patients, particularly lung transplan...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

Transplantation of ovarian tissue
Publication date: November 2014 Source:Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology, Volume 28, Issue 8 Author(s): Jacques Donnez , Marie-Madeleine Dolmans Since the first live birth after orthotopic transplantation of frozen–thawed ovarian tissue, &gt;40 babies have been born. It is time to consider fertility preservation in women as one of the foremost challenges of the next decade and to offer women facing the risk of induced or iatrogenic premature menopause the best chances of becoming mothers. Heterotopic transplantation has also been attempted, with consistent restoration of end...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

Impact of Maternal Obesity on Perinatal and Childhood Outcomes
Publication date: Available online 1 November 2014 Source:Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology Author(s): Louise Santangeli , Naveed Sattar , Shahzya S. Huda Maternal obesity is of major consequence, affecting every aspect of maternity care including both short- and long-term effects on the health of the offspring. Obese mothers are at a higher risk of developing gestational diabetes and pre-eclampsia, potentially exposing the foetus to an adverse intrauterine environment. Maternal obesity is linked to foetal macrosomia, resulting in increased neonatal and maternal morbidity. Foetal ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

Obesity in pregnancy
Publication date: Available online 1 November 2014 Source:Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology Author(s): Chu Chin Lim , Tahir Mahmood The prevalence of obesity has reached alarming proportions globally, and continues to rise in both developed and developing countries. Maternal obesity has become one of the most commonly occurring risk factors in obstetric practice. The 2003–2005 report of the Confidential Enquiries into Maternal Deaths in the United Kingdom highlighted obesity as a significant risk for maternal death [1]. More than half of all women who died from direct or indirec...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

Induction of labour and intrapartum care in obese women
Publication date: Available online 22 October 2014 Source:Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology Author(s): Namiko Kobayashi , Boon H. Lim The rising incidence of obesity in pregnancy has a significant impact on the provision of health services around the world. Due to the pathophysiological processes associated with the condition, the obese pregnant woman is at increased risks of induction of labour, caesarean section, post-partum haemorrhage, infection, longer hospital stay, macrosomia and higher perinatal morbidity and mortality. Labour is more likely to be prolonged and dysfunction...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

The worldwide epidemic of obesity
This article describes the extent and the cost of the obesity epidemic, which although historically was seen as a disease of high-income countries, is now clearly a global epidemic that impacts low- and middle-income countries and indigenous groups who bear an ever-increasing burden of this disease. (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

Placental dysfunction in obese women and antenatal surveillance strategies
Publication date: Available online 16 October 2014 Source:Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology Author(s): Yadava B. Jeve , Justin C. Konje , Anjum Doshani This review is aimed at discussing placental dysfunction in obesity and its clinical implication in pregnancy as well as an antenatal surveillance strategy for these women. Maternal obesity is associated with adverse perinatal outcome. Obesity is an independent risk factor for fetal hyperinsulinaemia, birthweight and newborn adiposity. Maternal obesity is associated with childhood obesity and obesity in adult life. Obesity induces ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

The first trimester: Prediction and prevention of the great obstetrical syndromes
Publication date: Available online 14 October 2014 Source:Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology Author(s): Arianne Sweeting , Felicity Park , Jon Hyett A number of groups are currently examining the potential of screening for pre-eclampsia and gestational diabetes at 12 weeks' gestation. This can be performed at the time of combined first-trimester screening for aneuploidy using a similar method of regression analysis to combine multiple demographic and investigative factors. At present, research into the prediction of pre-eclampsia is more robust and is associated with the potential ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 19, 2014 Category: OBGYN Source Type: research

High Risk for Major Nonlimb Anomalies Associated with Lower-Limb Deficiency: A Population-Based Study
Conclusions: Nearly half of the cases with lower-limb deficiencies were found to have other major anomalies. In cases of preaxial lower-limb deficiencies, the risk for associated major anomalies was highest. Level of Evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence. (Source: The Journal of Bone and Joint Surgery)
Source: The Journal of Bone and Joint Surgery - November 19, 2014 Category: Orthopaedics Authors: Syvanen, J., Nietosvaara, Y., Ritvanen, A., Koskimies, E., Kauko, T., Helenius, I. Tags: Pediatrics Scientific Articles Source Type: research

Propozycje postępowania z noworodkiem w przypadku rozpoznania wady letalnej w okresie prenatalnym
Publication date: November–December 2014 Source:Pediatria Polska, Volume 89, Issue 6 Author(s): Krzysztof Szmyd , Robert Śmigiel , Barbara Królak-Olejnik Congenital defects are some of the most common reasons of neonatal morbidity and in some cases those may have lethal prognosis. Progress in the diagnostics of congenital defects enables most cases to be diagnosed prenatally. Because of that reason, the number of newborn with lethal defect diagnosed prenatally increases. Diagnosis of lethal defect in child leaves parents and physicians in dire straights. The proposal of recommendation in the management of neonates wi...
Source: Pediatria Polska - November 19, 2014 Category: Pediatrics Source Type: research

Calcium channel blockers are effective as first line for tocolysis in the management of preterm labour
This study aimed to assess the effects of calcium channel blockers (CCBs) on maternal, fetal and neonatal outcomes when administered to women in preterm labour. Methods This was an updated review of randomised trials using CCBs as tocolytics for management of preterm birth. Maternal, fetal and neonatal outcomes were compared between CCBs (mainly... (Source: Evidence-Based Medicine)
Source: Evidence-Based Medicine - November 19, 2014 Category: Internal Medicine Authors: Brown, R. G., MacIntyre, D. A. Tags: Epidemiologic studies, Drugs: cardiovascular system, Drugs: CNS (not psychiatric), Contraception, Drugs: obstetrics and gynaecology, Pregnancy, Drugs: musculoskeletal and joint diseases Therapeutics Source Type: research

Elective induction of labour is associated with decreased perinatal mortality and lower odds of caesarean section at 40 and 41 weeks
Commentary on: Wood S, Cooper S, Ross S. Does induction of labour increase the risk of caesarean section? A systematic review and meta-analysis of trials in women with intact membranes. BJOG 2014;121:674–85. Context It is widely believed that induction of labour increases the chance of caesarean delivery, posing unnecessary risks to mother and fetus.1 2 While many past observational studies have found higher risk of adverse outcomes with elective induction, these studies have all had a singular methodological flaw, in that they have been designed to compare induction of labour to spontaneous labour at the same gestat...
Source: Evidence-Based Medicine - November 19, 2014 Category: Internal Medicine Authors: Caughey, A. B. Tags: EBM Aetiology, Epidemiologic studies, Pregnancy Source Type: research

Maternal body mass index increasing above 20 is associated with increased risk of miscarriage, stillbirth, neonatal death and postneonatal death
This study examines the association between maternal BMI and the full range of fetal and infant mortality outcomes. Methods This was a review of cohort studies reporting adjusted relative risk estimates of fetal and infant death for at least three categories of maternal BMI reported before or during early... (Source: Evidence-Based Medicine)
Source: Evidence-Based Medicine - November 19, 2014 Category: Internal Medicine Authors: Bell, R. Tags: EBM Aetiology, Epidemiologic studies, Obesity (nutrition), Pregnancy, Health education Source Type: research