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This page shows you the most recent publications within this specialty of the MedWorm directory.

Population Health: Modest Glycaemic Improvements in a Pregnant Cohort with Mild Glucose Intolerance Decreased Adverse Outcomes
ConclusionsModestly improved population distribution of glucose tolerance in pregnancies affected by mild glucose intolerance translated to meaningful improvements in perinatal outcomes. (Source: Paediatric and Perinatal Epidemiology)
Source: Paediatric and Perinatal Epidemiology - April 15, 2014 Category: Perinatology & Neonatology Authors: Erica K. Berggren, Kim A. Boggess, Michele Jonsson Funk Tags: Original Article Source Type: research

Seroprevalence and transmission of Hepatitis B virus among delivering women and their new born in selected health facilities, Addis Ababa, Ethiopia: a cross sectional study
Conclusion: Though the maternal positivity rate was low, the rate of positivity in cord bloods was almost equal to those infected mothers. Therefore, screening of pregnant mothers and vaccination of infants could help to reduce the transmission. To minimize the higher overall risk exposure status of mothers, increasing awareness and intensive public health education is also recommended. (Source: BioMed Central)
Source: BioMed Central - April 15, 2014 Category: Journals (General) Authors: Dessie TegegneKassu DestaBelete TegbaruTesfaye Tilahun Source Type: research

Paired measurement of urinary creatinine in neonates based on a Jaffe and an enzymatic IDMS-traceable assay
Conclusions: The tested IDMS-traceable assays showed interchangeable in heterogeneous neonatal urine samples. Using these assays, neonatal urinary creatinine showed 5-20 fold lower values than those observed in children or adults with a significant negative correlation with postnatal age. (Source: BMC Nephrology)
Source: BMC Nephrology - April 15, 2014 Category: Urology & Nephrology Authors: Karel AllegaertPieter VermeerschAnne SmitsDjalila MekahliElena LevtchenkoSteven Pauwels Source Type: research

Discrepancy in placental echogenicity: a sign of twin anemia polycythemia sequence
We present two cases of monochorionic diamniotic twins, in which the diagnosis of TAPS was made after documenting a discrepancy in the echodensities of the two portions of the placenta. Postnatal hemoglobin differences between the twins confirmed the diagnosis of TAPS. On the basis of these two cases, it appears that the heterogeneity in placental echogenicity is a sign of TAPS and Doppler measurement of middle cerebral artery peak systolic velocity is helpful for early diagnosis and management with timely delivery. © 2014 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - April 15, 2014 Category: Perinatology & Neonatology Authors: Vani C. Movva, Asha Rijhsinghani Tags: Research Letter Source Type: research

Rapid Measurement of Human Milk Macronutrients in the Neonatal Intensive Care Unit: Accuracy and Precision of Fourier Transform Mid-Infrared Spectroscopy
Conclusion: The FT mid-IR spectroscope demonstrated high accuracy in measurement of total protein and fat of preterm and term milk with high precision. (Source: Journal of Human Lactation)
Source: Journal of Human Lactation - April 15, 2014 Category: Nursing Authors: Smilowitz, J. T., Gho, D. S., Mirmiran, M., German, J. B., Underwood, M. A. Tags: Original Research Source Type: research

The Wellbeing of Infants Exposed to Buprenorphine via Breast Milk at 4 Weeks of Age
Conclusion: No adverse effects were detected in infants exposed to buprenorphine via breast milk up to 4 weeks postnatally. Further research using larger samples to assess possible developmental effects over longer periods of time is required. (Source: Journal of Human Lactation)
Source: Journal of Human Lactation - April 15, 2014 Category: Nursing Authors: Gower, S., Bartu, A., Ilett, K. F., Doherty, D., McLaurin, R., Hamilton, D. Tags: Original Research Source Type: research

Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function
The endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STIM1) has been implicated as a key mediator of store-dependent and store-independent Ca2+ entry pathways and maintenance of ER structure. STIM1 is present in embryonic, neonatal, and adult cardiomyocytes and has been strongly implicated in hypertrophic signaling; however, the physiological role of STIM1 in the adult heart remains unknown. We, therefore, developed a novel cardiomyocyte-restricted STIM1 knockout (crSTIM1-KO) mouse. In cardiomyocytes isolated from crSTIM1-KO mice, STIM1 expression was reduced by ~92% with no change in the expression o...
Source: AJP: Heart and Circulatory Physiology - April 15, 2014 Category: Cardiology Authors: Collins, H. E., He, L., Zou, L., Qu, J., Zhou, L., Litovsky, S. H., Yang, Q., Young, M. E., Marchase, R. B., Chatham, J. C. Tags: RAPID REPORTS Source Type: research

Cardiomyocyte glycophagy is regulated by insulin and exposure to high extracellular glucose
This study suggests that the regulation of glycogen content and glycophagy induction in the cardiomyocyte may be linked, and it is speculated that glycogen pathology in diabetic cardiomyopathy has glycophagic involvement. (Source: AJP: Heart and Circulatory Physiology)
Source: AJP: Heart and Circulatory Physiology - April 15, 2014 Category: Cardiology Authors: Mellor, K. M., Varma, U., Stapleton, D. I., Delbridge, L. M. D. Tags: RAPID REPORTS Source Type: research

PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways
In conclusion, PDE2 accelerates CF to MyoCF conversion, which leads to greater stiffness in ECTs. Atrial natriuretic peptide- and sodium nitroprusside-mediated cGMP synthesis completely reverses PDE2-induced fibroblast conversion. Thus PDE2 may augment cardiac remodeling, but this effect can also be overcome by enhanced cGMP. The redundant role of cAMP and cGMP as antifibrotic meditators may be viewed as a protective mechanism in heart failure. (Source: AJP: Heart and Circulatory Physiology)
Source: AJP: Heart and Circulatory Physiology - April 15, 2014 Category: Cardiology Authors: Vettel, C., Lammle, S., Ewens, S., Cervirgen, C., Emons, J., Ongherth, A., Dewenter, M., Lindner, D., Westermann, D., Nikolaev, V. O., Lutz, S., Zimmermann, W. H., El-Armouche, A. Tags: RAPID REPORTS Source Type: research

Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide
Bronchopulmonary dysplasia (BPD), a lung disease of prematurely born infants, is characterized in part by arrested development of pulmonary alveolae. We hypothesized that heme oxygenase (HO-1) and its byproduct carbon monoxide (CO), which are thought to be cytoprotective against redox stress, mitigate lung injury and alveolar simplification in hyperoxia-exposed neonatal mice, a model of BPD. Three-day-old C57BL/6J mice were exposed to air or hyperoxia (FiO2, 75%) in the presence or absence of inhaled CO (250 ppm for 1 h twice daily) for 21 days. Hyperoxic exposure increased mean linear intercept, a measure of alveolar simp...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Authors: Anyanwu, A. C., Bentley, J. K., Popova, A. P., Malas, O., Alghanem, H., Goldsmith, A. M., Hershenson, M. B., Pinsky, D. J. Tags: ARTICLES Source Type: research

Clinical spectrum of females with HCCS mutation: from no clinical signs to a neonatal lethal form of the microphthalmia with linear skin defects (MLS) syndrome
Conclusion: Our findings showed a wide phenotypic spectrum ranging from asymptomatic females with an HCCS mutation to patients with a neonatal lethal MLS form. Somatic mosaicism and the different ability of embryonic cells to cope with an OXPHOS defect and/or enhanced cell death upon HCCS deficiency likely underlie the great variability in phenotypes. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - April 15, 2014 Category: Internal Medicine Authors: Vanessa van RahdenIsabella RauSigrid FuchsFriederike KosynaHiram de AlmeidaHelen FryssiraBertrand IsidorAnna JauchMadeleine JoubertAugusta LachmeijerChristiane ZweierUte MoogKerstin Kutsche Source Type: research

Genetic testing in cardiovascular diseases
Purpose of reviewThe review is designed to outline the major developments in genetic testing in the cardiovascular arena in the past year or so. This is an exciting time in genetic testing as whole exome and whole genome approaches finally reach the clinic. These new approaches offer insight into disease causation in families in which this might previously have been inaccessible, and also bring a wide range of interpretative challenges. Recent findingsAmong the most significant recent findings has been the extent of physiologic rare coding variation in the human genome. New disease genes have been identified through whole ...
Source: Current Opinion in Cardiology - April 14, 2014 Category: Cardiology Tags: MOLECULAR GENETICS: Edited by Ali J. Marian Source Type: research

Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model
ConclusionsDexmedetomidine clearance was reduced almost tenfold compared with adult values in the newborn piglet following hypoxic‐ischaemic brain injury and subsequent therapeutic hypothermia. Reduced clearance was related to cumulative effects of both hypothermia and exposure to hypoxia. High plasma levels of dexmedetomidine were associated with major cardiovascular complications. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - April 14, 2014 Category: Anesthesiology Authors: M. EZZATI, K. BROAD, G. KAWANO, S. FAULKNER, J. HASSELL, B. FLEISS, P. GRESSENS, I. FIERENS, J. ROSTAMI, M. MAZE, J. W. SLEIGH, B. ANDERSON, R. D. SANDERS, N. J. ROBERTSON Tags: Original Article Source Type: research

Essential role for the TRF2 telomere protein in adult skin homeostasis
Summary TRF2 is a component of shelterin, the protein complex that protects the ends of mammalian chromosomes. TRF2 is essential for telomere capping owing to its roles in suppressing an ATM‐dependent DNA damage response (DDR) at chromosome ends and inhibiting end‐to‐end chromosome fusions. Mice deficient for TRF2 are early embryonic lethal. However, the role of TRF2 in later stages of development and in the adult organism remains largely unaddressed, with the exception of liver, where TRF2 was found to be dispensable for maintaining tissue function. Here, we study the impact of TRF2 conditional deletion in stratifie...
Source: Aging Cell - April 14, 2014 Category: Cytology Authors: Paula Martínez, Iole Ferrara‐Romeo, Juana M. Flores, Maria A. Blasco Tags: Original Article Source Type: research

Neonatal MSG Treatment Causes Obesity, Diabetes, and Macrovesicular Steatohepatitis with Liver Nodules in DIAR Mice
ConclusionsDIAR‐MSG had NASH‐like liver pathology and liver nodules typically associated with MS symptoms. DIAR‐MSG provides a valuable animal model to analyze NASH pathogenesis and carcinogenesis. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - April 14, 2014 Category: Gastroenterology Authors: Koichi Tsuneyama, Takeshi Nishida, Hayato Baba, Shu Taira, Makoto Fujimoto, Kazuhiro Nomoto, Shinichi Hayashi, Shigeharu Miwa, Takahiko Nakajima, Mitsuko Sutoh, Emu Oda, Ryoji Hokao, Johji Imura Tags: Experimental Hepatology Source Type: research

Potential first trimester metabolomic biomarkers of abnormal birth weight in healthy pregnancies
ConclusionSerum fingerprinting in early pregnancy can predict the risk of macrosomia. Serum levels of A‐FABP and several lipids are promising prognostic markers for macrosomia in healthy pregnancies. This article is protected by copyright. All rights reserved. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - April 14, 2014 Category: Perinatology & Neonatology Authors: Michal Ciborowski, Monika Zbucka‐Kretowska, Dorota Bomba‐Opon, Miroslaw Wielgos, Robert Brawura‐Biskupski‐Samaha, Piotr Pierzynski, Maciej Szmitkowski, Slawomir Wolczynski, Danuta Lipinska, Anna Citko, Witold Bauer, Maria Gorska, Adam Kretowski Tags: Original Article Source Type: research

Congenital lethal motor neuron disease with a novel defect in ribosome biogenesis
Conclusion: We report a patient with a SMARD phenotype due to a mutation in LAS1L, a gene important in coordinating processing of the 45S pre-rRNA and maturation of the large 60S ribosomal subunit. Similarly, the IGHMB2 gene associated with SMARD type 1 has been suggested to have an important role in ribosomal biogenesis from its role in processing the 45S pre-rRNA. We propose that disruption of ribosomal maturation may be a common pathogenic mechanism linking SMARD phenotypes caused by both IGHMBP2 and LAS1L. (Source: Neurology)
Source: Neurology - April 14, 2014 Category: Neurology Authors: Butterfield, R. J., Stevenson, T. J., Xing, L., Newcomb, T. M., Nelson, B., Zeng, W., Li, X., Lu, H.-M., Lu, H., Farwell Gonzalez, K. D., Wei, J.-P., Chao, E. C., Prior, T. W., Snyder, P. J., Bonkowsky, J. L., Swoboda, K. J. Tags: Anterior nerve cell disease, Peripheral neuropathy, Neonatal, All Genetics ARTICLE Source Type: research

Non-neurological, steroid-related adverse events in very low birth weight infants: a prospective audit.
CONCLUSIONS: The use of steroids was significantly associated with severe short-term adverse events - most importantly hypertrophic cardiomyopathy and thrombus formation. These complications must be taken into consideration when administering steroids to VLBW infants. PMID: 24706463 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 12, 2014 Category: Journals (General) Authors: Röhr SB, Sauer H, Gottschling S, Abdul-Khaliq H, Gortner L, Nunold H, Gräber S, Meyer S Tags: Swiss Med Wkly Source Type: research

Prognostic value of nucleated red blood cells in critically ill children.
CONCLUSIONS: NRBCs are not an independent risk factor for bad outcomes in paediatric intensive care. However, NRBCs may have some prognostic value in the first month of life. In children >1 month of age, the association between NRBC and outcome is much less pronounced. PMID: 24706413 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 12, 2014 Category: Journals (General) Authors: Schaer C, Schmugge M, Frey B Tags: Swiss Med Wkly Source Type: research

Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service.
CONCLUSIONS: The incidence of ROP was higher than that found in the literature. The main risk factors were related to extreme prematurity. CONTEXTO E OBJETIVO: A retinopatia da prematuridade (ROP) é causa conhecida de cegueira e diagnóstico e tratamento oportunos podem evitar graves danos à criança. Este estudo objetivou avaliar a incidência da ROP e sua associação com fatores de risco conhecidos. PMID: 24714988 [PubMed - in process] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - April 12, 2014 Category: Journals (General) Authors: Gonçalves E, Násser LS, Martelli DR, Alkmim IR, Mourão TV, Caldeira AP, Martelli-Júnior H Tags: Sao Paulo Med J Source Type: research

Non-pharmacological methods for relief of discomfort and pain in newborns: a collective nursing construction
This is a convergent care study with the aim to build, together with the nursing staff, a proposal for care protocol based on non-pharmacological methods for discomfort and pain management in newborns admitted to a neonatal intensive care unit. The study was carried out in a neonatal intensive care unit of a university hospital with 16 nursing staff professionals. Data were collected in two stages: first, a reflective-educational process was performed and, afterwards, a participant observation during the different work shifts of the nursing staff. The care protocol proposal will enable the standardization of care strategie...
Source: Texto e Contexto - Enfermagem - April 11, 2014 Category: Global & Universal Source Type: research

Resolving Disparity, One More Step
Breastfeeding Medicine Apr 2014, Vol. 9, No. 3: 111-112. (Source: Breastfeeding Medicine)
Source: Breastfeeding Medicine - April 11, 2014 Category: Perinatology & Neonatology Tags: article Source Type: research

Ethics and the WHO “International Code of Marketing of Breast-milk Substitutes”
Breastfeeding Medicine Apr 2014, Vol. 9, No. 3: 170-170. (Source: Breastfeeding Medicine)
Source: Breastfeeding Medicine - April 11, 2014 Category: Perinatology & Neonatology Tags: article Source Type: research

Effect of maternal obesity with and without gestational diabetes on offspring subcutaneous and preperitoneal adipose tissue development from birth up to year-1
Conclusion: Maternal pregravid obesity combined with GDM leads to newborn hyperinsulinemia and increased offspring fat mass until week-6, whereas pregravid obesity without GDM does not. This strongly suggests the pivotal role of GDM in the adverse offspring outcome. Maternal C-peptide and HMW adiponectin levels in pregnancy emerge to be predictive for elevated PPA in newborns and might be indicative for the obesity risk at later life. Altogether, the findings from our pilot study warrant evaluation in long-term studies.Trial registration: German Clinical Trials Register DRKS00004370 (Source: BMC Pregnancy and Childbirth - Latest articles)
Source: BMC Pregnancy and Childbirth - Latest articles - April 11, 2014 Category: OBGYN Authors: Kirsten UebelKarina PuschKurt GedrichKarl-Theo SchneiderHans HaunerBernhard Bader Source Type: research

Neonatal orbital abscess
Khalil M Al-Salem, Fawaz A Alsarayra, Areej R SomkawarIndian Journal of Ophthalmology 2014 62(3):354-357Orbital complications due to ethmoiditis are rare in neonates. A case of orbital abscess due to acute ethmoiditis in a 28-day-old girl is presented. A Successful outcome was achieved following antimicrobial therapy alone; spontaneous drainage of the abscess occurred from the lower lid without the need for surgery. From this case report, we intend to emphasize on eyelid retraction as a sign of neonatal orbital abscess, and to review all the available literature of similar cases. (Source: Indian Journal of Ophthalmology)
Source: Indian Journal of Ophthalmology - April 11, 2014 Category: Opthalmology Authors: Khalil M Al-SalemFawaz A AlsarayraAreej R Somkawar Source Type: research

Mouse Model for Intracellular Inositol Depletion [Developmental Biology]
In conclusion, our results reveal critical roles for intracellular myo-inositol synthesis in craniofacial development and the maintenance of proper brain function. Furthermore, this mouse model for cellular inositol depletion could be beneficial for understanding the molecular mechanisms underlying the clinical effect of lithium and myo-inositol-mediated skeletal development. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - April 11, 2014 Category: Chemistry Authors: Ohnishi, T., Murata, T., Watanabe, A., Hida, A., Ohba, H., Iwayama, Y., Mishima, K., Gondo, Y., Yoshikawa, T. Tags: Neurobiology Source Type: research

Neonatal outcomes among singleton births after blastocyst versus cleavage stage embryo transfer: a systematic review and meta-analysis
CONCLUSIONS Risk of PTB in IVF singleton pregnancies is significantly higher following blastocyst transfer compared with cleavage stage transfer. Risk of congenital anomalies may also be higher but further studies are needed to confirm this finding and to identify reasons for such outcomes. (Source: Human Reproduction Update)
Source: Human Reproduction Update - April 11, 2014 Category: OBGYN Authors: Dar, S., Lazer, T., Shah, P. S., Librach, C. L. Tags: Reviews Source Type: research

Epithelial‐mesenchymal transitions in bronchopulmonary dysplasia of newborn rats
ConclusionEMT of AT2 cells occurred in the hyperoxia‐induced newborn rat BPD model and resulted in attenuated alveolar development as a portion of the myofibroblasts accumulated in the lung originated from AT2 cells via EMT. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 11, 2014 Category: Respiratory Medicine Authors: Haiping Yang, Jianhua Fu, Xindong Xue, Li Yao, Lin Qiao, Ana Hou, Linlin Jin, Yujiao Xing Tags: Original Article: Neonatal Lung Disease Source Type: research

Risk of stillbirth and infant deaths after assisted reproductive technology: a Nordic study from the CoNARTaS group
STUDY QUESTION Is the risk of stillbirth and perinatal deaths increased after assisted reproductive technology (ART) compared with pregnancies established by spontaneous conception (SC)? SUMMARY ANSWER A significantly increased risk of stillbirth in ART singletons was only observed before 28 + 0 gestational weeks. WHAT IS KNOWN ALREADY The current literature indicates that children born after ART have an increased risk of perinatal death. The knowledge on stillbirth in ART pregnancies is limited. STUDY DESIGN, SIZE, DURATION A population based case–control study. PARTICIPANTS/MATERIALS, SETTING AND METHODS A tota...
Source: Human Reproduction - April 11, 2014 Category: Reproduction Medicine Authors: Henningsen, A. A., Wennerholm, U. B., Gissler, M., Romundstad, L. B., Nygren, K. G., Tiitinen, A., Skjaerven, R., Nyboe Andersen, A., Lidegaard, O., Forman, J. L., Pinborg, A. Tags: Reproductive epidemiology Source Type: research

Instrumental delivery and ultrasound : a multicentre randomised controlled trial of ultrasound assessment of the fetal head position versus standard care as an approach to prevent morbidity at instrumental delivery.
CONCLUSIONS: An ultrasound assessment prior to instrumental delivery reduced the incidence of incorrect diagnosis of the fetal head position without delaying delivery, but did not prevent morbidity. A more integrated clinical skills-based approach is likely to be required to prevent adverse outcomes at instrumental delivery. PMID: 24720273 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - April 11, 2014 Category: OBGYN Authors: Ramphul M, Ooi P, Burke G, Kennelly M, Said S, Montgomery A, Murphy D Tags: BJOG Source Type: research

Systematic review and meta‐analysis of optimal initial fraction of oxygen levels in the delivery room at ≤ 32 weeks
ConclusionThese data show that reduced mortality approached significance when a low iFiO2 (0.21‐0.30) was used for initial stabilisation, compared to a high iFiO2 (0.60‐1.0). There was no significant association for bronchopulmonary dysplasia or intraventricular haemorrhage when comparing low and high iFiO2. Based on present data, premature babies ≤ 32 weeks’ gestation in need of stabilisation in the delivery room should be given an iFiO2 of 0.21 to 0.30.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - April 10, 2014 Category: Pediatrics Authors: Ola Didrik Saugstad, Dagfinn Aune, Marta Aguar, Vishal Kapadia, Neil Finer, Maximo Vento Tags: Regular Article Source Type: research

Southend Hospital made no attempt to resuscitate premature baby boy Tom Godwin
First-time mother Tracy Godwin, 34, has finally received an apology from health chiefs - four years after her premature baby was left to die in her arms by Southend Hospital in Essex. (Source: the Mail online | Health)
Source: the Mail online | Health - April 10, 2014 Category: Consumer Health News Source Type: news

Diabetes in pregnancy among First Nations women in Alberta, Canada: a retrospective analysis
Conclusions: Although First Nations women experience a higher overall prevalence of diabetes in pregnancy, the lack of increase in the prevalence over time is encouraging. However, because high-risk pregnancies and poor outcomes are more common among First Nations women, particularly those with diabetes, strategies to improve perinatal care must be implemented. (Source: BMC Pregnancy and Childbirth - Latest articles)
Source: BMC Pregnancy and Childbirth - Latest articles - April 10, 2014 Category: OBGYN Authors: Richard OsterMalcolm KingDonald MorrishMaria MayanEllen Toth Source Type: research

Highlights from this issue
Size matters Not every speciality in medicine can demonstrate a clear relationship between the size or throughput of a service, and the quality of the outcome. But in neonatal medicine there has been increasing evidence from around the world that larger neonatal services have better outcomes. So what about England—is there any reason to think that we might be different? Marlow and colleagues, reporting their analysis of the EPIcure2 data, now give us a definitive answer: England is not different. In fact there is a consistent gradient in favour of lower gestational age specific mortality between smaller units (with t...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 10, 2014 Category: Perinatology & Neonatology Authors: Platt, M. W. Tags: Fantoms Source Type: research

Perinatal regionalisation in the UK: an international perspective
Extremely low gestational age neonates (ELGANs) are probably the most vulnerable of all patient groups. Caring for these infants requires specialised services with a good infrastructure, dedication of the entire team and experience. Numerous studies have shown that perinatal outcomes are better in large centres providing the highest level of care compared to smaller ones or those working in a less experienced or lower level setting.1 Nonetheless, drawing practical conclusions from these data, namely to rigorously centralise perinatal care, meets resistance, in the UK and abroad. Or how else can the recent findings by Marlo...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 10, 2014 Category: Perinatology & Neonatology Authors: Poets, C. F. Tags: Epidemiologic studies, Child health, Infant health, Neonatal health Editorials Source Type: research

Where should extreme preterm babies be delivered? Crucial data from EPICure
In the UK all maternity services require to be able to provide expert resuscitation for emergency or unpredicted deliveries, including those of extreme preterm babies. After initial stabilisation there is then a choice between retaining the infant in the local neonatal unit or transferring to a larger perinatal centre. Where an extreme preterm baby is to be delivered electively, parents may require, with guidance, to decide whether to deliver close to home or to elect to travel further afield to a larger perinatal centre. It is the responsibility of involved professionals to help such parents make informed choices for thei...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 10, 2014 Category: Perinatology & Neonatology Authors: Laing, I. A. Tags: Epidemiologic studies, Child health, Infant health, Neonatal and paediatric intensive care, Neonatal health, Neonatal intensive care, Sexual health, Resuscitation Editorials Source Type: research

To snip or not to snip: the dilemmas of tongue-tie
As a medical student I was taught by an eminent paediatric surgeon that tongue-tie never required treatment "unless they wanted to play the trumpet" and as a registrar I was appalled to find that a consultant paediatrician was snipping tongue-ties in the clinic—a practice I had been taught was "unnecessary, dangerous and cruel". However, when approached 10 years ago by an experienced midwifery colleague whose own tongue-tied infant was having great difficulty in breast feeding and failing to thrive, I was surprised to find that, although not of high quality, there was reported evidence for the treatment of tongu...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 10, 2014 Category: Perinatology & Neonatology Authors: Lawson, A. Tags: Immunology (including allergy), Vaccination / immunisation, Childhood nutrition, Reproductive medicine, Infant nutrition (including breastfeeding), Undergraduate, Medical humanities Editorials Source Type: research

Phenylephrine eye drops: a rare complication in preterm neonate
An ex 27-week baby, corrected to 34 weeks, was administered phenylephrine 2.5% and cyclopentolate 0.5%, one drop per eye, 5 min apart for retinopathy of prematurity (ROP) screening. Within 20 min, the baby developed bilateral periorbital pallor. Blood pressure, heart rate and oxygen saturations remained unchanged. The periorbital pallor resolved completely with no damage to the skin in the next 24 h. This is a well-recognised, local, non-idiosyncratic effect caused by overflow and absorption of phenylephrine 2.5% through the skin.1 Systemic absorption of topical ocular drugs can occur via nasal mucosa, ...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 10, 2014 Category: Perinatology & Neonatology Authors: Sesham, R., Puvanachandra, N., Muthukumar, P. Tags: Journalology, Eye Diseases, Drugs: cardiovascular system, Hypertension, Ophthalmology, Screening (epidemiology), Competing interests (ethics), Screening (public health) Images in neonatal medicine Source Type: research

Perinatal outcomes for extremely preterm babies in relation to place of birth in England: the EPICure 2 study
Background Expertise and resources may be important determinants of outcome for extremely preterm babies. We evaluated the effect of place of birth and perinatal transfer on survival and neonatal morbidity within a prospective cohort of births between 22 and 26 weeks of gestation in England during 2006. Methods We studied the whole population of 2460 births where the fetus was alive at the admission of the mother to hospital for delivery. Outcomes to discharge were compared between level 3 (most intensive) and level 2 maternity services, with and without transfers, and by activity level of level 3 neonatal unit; ORs ...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 10, 2014 Category: Perinatology & Neonatology Authors: Marlow, N., Bennett, C., Draper, E. S., Hennessy, E. M., Morgan, A. S., Costeloe, K. L. Tags: Epidemiologic studies, Open access, Editor's choice, Child health, Neonatal and paediatric intensive care, Neonatal health Original articles Source Type: research

Randomised controlled trial of early frenotomy in breastfed infants with mild-moderate tongue-tie
Conclusions Early frenotomy did not result in an objective improvement in breastfeeding but was associated with improved self-efficacy. The majority in the comparison arm opted for the intervention after 5 days. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 10, 2014 Category: Perinatology & Neonatology Authors: Emond, A., Ingram, J., Johnson, D., Blair, P., Whitelaw, A., Copeland, M., Sutcliffe, A. Tags: Clinical trials (epidemiology), Open access, Pain (neurology), Childhood nutrition, Reproductive medicine, Infant nutrition (including breastfeeding) Original articles Source Type: research

Retinopathy of prematurity in English neonatal units: a national population-based analysis using NHS operational data
Conclusions Understanding organisational differences between neonatal units may help improve ROP screening. Patient-level electronic NHS clinical data offer opportunity for future rapid, low cost, population-based evaluations but require improved data entry. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 10, 2014 Category: Perinatology & Neonatology Authors: Wong, H. S., Santhakumaran, S., Statnikov, Y., Gray, D., Watkinson, M., Modi, N., and the UK Neonatal Collaborative Tags: Eye Diseases, Epidemiologic studies, Ophthalmology, Child health, Neonatal and paediatric intensive care, Neonatal health, Screening (epidemiology), Screening (public health) Original articles Source Type: research