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This page shows you the most recent publications within this specialty of the MedWorm directory.

Perinatal exposure to germinated brown rice and its gamma amino-butyric acid-rich extract prevents high fat diet-induced insulin resistance in first generation rat offspring.
CONCLUSIONS: These results showed that intrauterine exposure to GBR-influenced metabolic outcomes in offspring of rats with underlying epigenetic changes and transcriptional implications that led to improved glucose homeostasis. PMID: 26842399 [PubMed] (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - February 5, 2016 Category: Nutrition Authors: Adamu HA, Imam MU, Ooi DJ, Esa NM, Rosli R, Ismail M Tags: Food Nutr Res Source Type: research

Continuing Education Course.
Authors: PMID: 26842542 [PubMed - in process] (Source: Neonatal Network)
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Tags: Neonatal Netw Source Type: research

News of the Academy of Neonatal Nursing.
Authors: PMID: 26842541 [PubMed - in process] (Source: Neonatal Network)
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Tags: Neonatal Netw Source Type: research

Supporting Parents with Mental Health Support in the NICU.
Abstract Parents of premature babies are at high risk for postpartum depression and Posttraumatic stress disorder and need a lot of mental health support. Enter Parijat Deshpande, a mother who gave birth to her son in the 24th week and has a background in psychology and is now a health and wellness counselor. Parijat has a strong focus on perinatal wellness and helping parents of a preemie reduce their stress and increase the parent-child bond. PMID: 26842540 [PubMed - in process] (Source: Neonatal Network)
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Authors: Discenza D Tags: Neonatal Netw Source Type: research

Advertising Index.
Authors: PMID: 26842539 [PubMed - in process] (Source: Neonatal Network)
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Tags: Neonatal Netw Source Type: research

Early Blood Transfusion and Resolution of Disseminated Intravascular Coagulation Associated with Massive Subgaleal Hemorrhage.
Abstract A male infant delivered to a primipara woman following vacuum applications. He was vigorous at birth, with small caput and scalp bruising. His head was enlarging; he became pale with respiratory distress. Subgaleal hemorrhage (SGH) was suspected. His hematocrit was noted to be 26.2 percent prior to transfusion of O, Rh-negative blood (40 mL/kg). Moderate disseminated intravascular coagulation (DIC) was noted at 12 hours of age. Posttransfusion of fresh frozen plasma (FFP), his condition became stable, and DIC gradually resolved. Head magnetic resonance imaging did not show intracranial hemorrhage. Although...
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Authors: Modanlou H, Hutson S, Merritt AT Tags: Neonatal Netw Source Type: research

Trisomy 13: Changing Perspectives.
Abstract The diagnosis of trisomy 13 has been considered incompatible with life. Trisomy 13 is associated with a pattern of congenital anomalies and mental disabilities that make caring for these infants a challenge for both the family and health care professionals. The clinical management of trisomy 13 varies based on the organ systems involved. The current standard of care has been withholding intensive support and providing comfort care. Recent literature suggests there are improved outcomes in infants who receive intensive care at birth. In addition, case reports evaluating older children with trisomy 13 report...
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Authors: Macias G, Riley C Tags: Neonatal Netw Source Type: research

Management of Epidermolytic Ichthyosis in the Newborn.
Abstract Epidermolytic ichthyosis (EI) is a rare autosomal dominant genodermatosis that presents at birth as a bullous disease, followed by a lifelong ichthyotic skin disorder. Essentially, it is a defective keratinization caused by mutations of keratin 1 (KRT1) or keratin 10 (KRT10) genes, which lead to skin fragility, blistering, and eventually hyperkeratosis. Successful management of EI in the newborn period can be achieved through a thoughtful, directed, and interdisciplinary or multidisciplinary approach that encompasses family support. This condition requires meticulous care to avoid associated morbidities su...
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Authors: Avril M, Riley C Tags: Neonatal Netw Source Type: research

Septo-Optic Dysplasia: A Case Study.
Abstract Septo-optic dysplasia (SOD) is a rare congenital heterogeneous malformation. SOD was formerly known as de Morsier syndrome, which associated a midline brain defect such as an absent septum pellucidum with optic nerve hypoplasia. The diagnosis of SOD is made when there are two or more characteristics of the classic triad. The triad consists of optic nerve hypoplasia, pituitary hormone abnormalities, and midline brain defects, although it can vary in the severity of clinical presentation and phenotype. The purpose of this article is to review a case and analyze the literature regarding prevalence, etiology, ...
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Authors: Musgrove JM, Riley C Tags: Neonatal Netw Source Type: research

Staphylococcal Scalded Skin Syndrome: A Case Review.
Abstract Staphylococcal scalded skin syndrome (SSSS) is a rare yet well-known exfoliative skin syndrome. It involves extensive desquamated areas caused by an exfoliative toxin from Staphylococcus aureus. The typical presentation of SSSS allows for early diagnosis and treatment of the disease. Knowing and understanding the prevalence, pathophysiology, risk factors, and diagnosis of SSSS will ensure that infants being treated and cared for by neonatal nurses and neonatal nurse practitioners will receive appropriate, comprehensive, and multidisciplinary care while in the NICU. The purpose of this case review is to inf...
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Authors: Hennigan K, Riley C Tags: Neonatal Netw Source Type: research

Academic Excellence Ignites Leadership Potential.
PMID: 26842533 [PubMed - in process] (Source: Neonatal Network)
Source: Neonatal Network - February 5, 2016 Category: Perinatology & Neonatology Authors: Riley C Tags: Neonatal Netw Source Type: research

 Hepatic immunohistochemistry of bile transporters in progressive familial intrahepatic cholestasis.
CONCLUSION: MDR3 and BSEP immunostaining would be a helpful tool in supporting the phenotypic diagnosis of PFIC subtypes and in differentiating PFIC from other causes of neonatal cholestasis. PMID: 26845599 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 5, 2016 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Maternal and neonatal outcomes of antenatal anemia in a Scottish population: a retrospective cohort study
ConclusionsThis study shows the incidence of antenatal anemia is decreasing steadily within this Scottish population. However, given that anemia is a readily correctable risk factor for major causes of morbidity and mortality in the UK, further work is required to investigate appropriate preventive measures.This article is protected by copyright. All rights reserved. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 5, 2016 Category: OBGYN Authors: Ruramayi Rukuni, Sohinee Bhattacharya, Michael F Murphy, David Roberts, Simon J Stanworth, Marian Knight Tags: Original Research Article Source Type: research

[Editorial] Screening for perinatal depression: a missed opportunity
All pregnant and post-partum women should be routinely screened for depression, according to a new statement from the US Preventive Services Task Force (USPSTF). This controversial recommendation is part of the USPSTF's updated 2016 guidance recommending routine screening for depression in adults, published on Jan 26, which for the first time has been expanded to include information related to pregnant and post-partum women. The task force's proposals were widely welcomed by the mainstream media—but given the limited evidence in this area, are such bold recommendations warranted? (Source: LANCET)
Source: LANCET - February 5, 2016 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research

[Correspondence] Bacterial neonatal sepsis and antibiotic resistance in low-income countries
Tackling neonatal sepsis and antibiotic resistance is extremely challenging in low-income countries where neonatal mortality is high and antibiotic resistance is growing.1,2 Essential data on the burden of severe bacterial infections in neonates and bacterial causes are scarce in low-income countries, and the role of antibiotic resistance remains unclear. (Source: LANCET)
Source: LANCET - February 5, 2016 Category: Journals (General) Authors: Bich-Tram Huynh, Michael Padget, Benoit Garin, Elisabeth Delarocque-Astagneau, Didier Guillemot, BIRDY study group Tags: Correspondence Source Type: research

Improvised Neonatal Care–Realizing the Gaps in a Disaster Zone
Brief Report Joseph Mendlovic, Dov Albukrek, David Dagan, Ofer Merin, Giora Weiser, Prehospital and Disaster Medicine, Volume 31 Issue 01, pp 111-113Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - February 5, 2016 Category: Emergency Medicine Source Type: research

Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-analysis.
CONCLUSIONS: SCH during pregnancy is associated with multiple adverse maternal and neonatal outcomes. The value of levothyroxine therapy in preventing these adverse outcomes remains uncertain. PMID: 26837268 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - February 5, 2016 Category: Endocrinology Tags: Thyroid Source Type: research

Donohue syndrome. Extreme insulin resistance in the neonatal period
Publication date: Available online 4 February 2016 Source:Endocrinología y Nutrición (English Edition) Author(s): Rosa María Sánchez-Hernández, María Martín-Frías, Luis Castaño, Adelaida Lamas, Raquel Barrio (Source: Endocrinologia y Nutricion)
Source: Endocrinologia y Nutricion - February 5, 2016 Category: Endocrinology Source Type: research

Distinct hemispheric specializations for native and non-native languages in one-day-old newborns identified by fNIRS
This study assessed whether the neonatal brain recruits different neural networks for native and non-native languages at birth. Twenty-seven one-day-old full-term infants underwent functional near-infrared spectroscopy (fNIRS) recording during linguistic and non-linguistic stimulation. Fourteen newborns listened to linguistic stimuli (native and non-native language stories) and 13 newborns were exposed to non-linguistic conditions (native and non-native stimuli played in reverse). Comparisons between left and right hemisphere oxyhemoglobin (HbO2) concentration changes over the temporal areas revealed clear left hemisphere ...
Source: Neuropsychologia - February 5, 2016 Category: Neurology Source Type: research

Maternal ‘near miss’ at Royal Darwin Hospital – an analysis of severe maternal morbidity at an Australian regional tertiary maternity unit
ConclusionThe rates of maternal ‘near miss’ at RDH are consistent with other studies in the developed world. The WHO maternal ‘near‐miss’ audit tool helps health professionals understand and anticipate severe maternal morbidities, with the aim of improving maternal and perinatal outcomes. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - February 5, 2016 Category: OBGYN Authors: Skandarupan Jayaratnam, Alice Burton, Kirsten Fiona Connan, Caroline Costa Tags: Original Article Source Type: research

Hypothermia improves disease manifestations in SMA mice via SMN augmentation
In this study, we evaluated the efficacy of intermittent transient hypothermia in a mouse model of SMA. SMA mice were exposed to ice for 50 s to achieve transient hypothermia (below 25°C) daily beginning on postnatal day 1. Neonatal SMA mice (Smn–/–SMN2+/–) who received daily transient hypothermia exhibited reduced motor neuron degeneration and muscle atrophy and preserved the architecture of neuromuscular junction when compared with untreated controls at day 8 post-treatment. Daily hypothermia also prolonged the lifespan, increased body weight and improved motor coordination in SMA mice. Quantitative...
Source: Human Molecular Genetics - February 5, 2016 Category: Genetics & Stem Cells Authors: Tsai, L.-K., Chen, C.-L., Tsai, Y.-C., Ting, C.-H., Chien, Y.-H., Lee, N.-C., Hwu, W.-L. Tags: ARTICLES Source Type: research

Deletion of the miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour
The brain-specific miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 domain is implicated in several aspects of brain development and function, particularly in fine-tuning the dendritic outgrowth and spine remodelling of hippocampal neurons. Whether it might influence behaviour and memory-related processes has not yet been explored at the whole organism level. We previously reported that constitutive deletion of the miR-379/miR-410 gene cluster affects metabolic adaptation in neonatal mice. Here, we examined the role of this cluster in adult brain functions by subjecting mice with the constitutive deletion to a batte...
Source: Human Molecular Genetics - February 5, 2016 Category: Genetics & Stem Cells Authors: Marty, V., Labialle, S., Bortolin-Cavaille, M.-L., Ferreira De Medeiros, G., Moisan, M.-P., Florian, C., Cavaille, J. Tags: ARTICLES Source Type: research

GRK2 Inhibition Retards Cardiometabolic Dysfunction [Signal Transduction]
Impairment of myocardial fatty acid substrate metabolism is characteristic of late-stage heart failure and has limited treatment options. Here, we investigated whether inhibition of G-protein-coupled receptor kinase 2 (GRK2) could counteract the disturbed substrate metabolism of late-stage heart failure. The heart failure-like substrate metabolism was reproduced in a novel transgenic model of myocardium-specific expression of fatty acid synthase (FASN), the major palmitate-synthesizing enzyme. The increased fatty acid utilization of FASN transgenic neonatal cardiomyocytes rapidly switched to a heart failure phenotype in an...
Source: Journal of Biological Chemistry - February 5, 2016 Category: Chemistry Authors: Abd Alla, J., Graemer, M., Fu, X., Quitterer, U. Tags: Molecular Bases of Disease Source Type: research

Trial: Metformin Slows Weight Gain in Obese Pregnant Women (CME/CE)
(MedPage Today) -- But did not affect neonatal birthweight (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - February 4, 2016 Category: Endocrinology Source Type: news

Clinical and pathological challenges in the diagnosis of late-onset biliary atresia: four case studies.
We report four cases of late-onset BA in infants older than 4 weeks (3 males, 1 female), and describe the diagnostic and management difficulties. One of the cases had a late-onset (29 weeks) presentation with a successful surgical procedure. We highlight the importance of this unusual differential diagnosis in infants with cholestatic syndrome, who may benefit from Kasai surgery, regardless of age. PMID: 26840713 [PubMed - as supplied by publisher] (Source: Brazilian Journal of Medical and Biological Research)
Source: Brazilian Journal of Medical and Biological Research - February 4, 2016 Category: Research Tags: Braz J Med Biol Res Source Type: research

Newborn Congenital Malformations Associated With Prenatal Exposure to Drugs in Kentucky, 2009-2013.
CONCLUSIONS: Further research is needed to identify specific risk factors (eg, drug classes, tobacco) and toxicities (eg, intake amount, frequency of intake, drug metabolism) associated with congenital malformation diagnoses following prenatal exposure to drugs. PMID: 26840971 [PubMed - as supplied by publisher] (Source: Southern Medical Journal)
Source: Southern Medical Journal - February 4, 2016 Category: Journals (General) Tags: South Med J Source Type: research

Steroids May Help More Than Just Premature Babies
Researchers found they reduced risk for respiratory problems in infants born at 34 to 36 weeks (Source: WebMD Health)
Source: WebMD Health - February 4, 2016 Category: Consumer Health News Source Type: news

Saving Newborn Babies – The Benefits of Interventions in Neonatal Care in Norway over More Than 40 Years
Abstract The aim of this study was to examine the effect that the introduction of new medical interventions at birth has had on mortality among newborn babies in Norway during the period 1967–2011. During this period, there has been a significant decline in mortality, in particular for low birth weight infants. We identified four interventions that together explained about 50% of the decline in early neonatal and infant mortality: ventilators, antenatal steroids, surfactant and insure. The analyses were performed on a large set of data, encompassing more than 1.6 million deliveries (Medical Birth Registry of Norway). The...
Source: Health Economics - February 4, 2016 Category: Health Management Authors: Jostein Grytten, Lars Monkerud, Irene Skau, Anne Eskild, Rune J. Sørensen, Ola Didrik Saugstad Tags: Research Article Source Type: research

Involving the Family in Developmental Care of the NICU BabyInvolving the Family in Developmental Care of the NICU Baby
What can be done to increase involvement of the family in the developmental care of their NICU baby? Journal of Perinatology : Official Journal of the California Perinatal Association (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 4, 2016 Category: Intensive Care Tags: Pediatrics Journal Article Source Type: news

Plasma Kisspeptin Levels in Newborn Infants with Breast Enlargement.
CONCLUSION: The findings of this study suggest that plasma kisspeptin and serum prolactin levels may be involved in the physiopathology of breast enlargement in newborns. PMID: 26831552 [PubMed - in process] (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - February 4, 2016 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Cryptosporidium parvum: from foal to veterinary students
Publication date: Available online 3 February 2016 Source:Veterinary Parasitology Author(s): R. Galuppi, S. Piva, C. Castagnetti, G. Sarli, E. Iacono, M.L. Fioravanti, M. Caffara This paper describes the transmission of a zoonotic subtype of Cryptosporidium parvum between two foals hospitalized in an Equine Perinatology Unit (EPU) linked to an outbreak of cryptosporidiosis in veterinary students. Fecal specimens of 36 mares (105 samples) and 28 foals (122 samples) were subjected to Ziehl-Neelsen staining, nested PCR of 18S rDNA. Two foals tested positive for Cryptosporidium; PCR restriction fragment length polymor...
Source: Veterinary Parasitology - February 4, 2016 Category: Veterinary Research Source Type: research

A Transient Translaminar GABAergic Interneuron Circuit Connects Thalamocortical Recipient Layers in Neonatal Somatosensory Cortex
Publication date: 3 February 2016 Source:Neuron, Volume 89, Issue 3 Author(s): Andre Marques-Smith, Daniel Lyngholm, Anna-Kristin Kaufmann, Jacqueline A. Stacey, Anna Hoerder-Suabedissen, Esther B.E. Becker, Michael C. Wilson, Zoltán Molnár, Simon J.B. Butt GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thalamocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using las...
Source: Neuron - February 4, 2016 Category: Neuroscience Source Type: research

Sex-specific effects of N-Acetylcysteine in neonatal rats treated with hypothermia after severe hypoxia-ischemia
Publication date: Available online 3 February 2016 Source:Neuroscience Research Author(s): Xingju Nie, Danielle W. Lowe, Laura Grace Rollins, Jessica Bentzley, Jamie L. Fraser, Renee Martin, Inderjit Singh, Dorothea Jenkins Approximately half of moderate to severely hypoxic-ischemic (HI) newborns do not respond to hypothermia, the only proven neuroprotective treatment. N-Acetylcysteine (NAC), an antioxidant and glutathione precursor, shows promise for neuroprotection in combination with hypothermia, mitigating post-HI neuroinflammation due to oxidative stress. As mechanisms of HI injury and cell death differ in m...
Source: Neuroscience Research - February 4, 2016 Category: Neuroscience Source Type: research

Neonatal Ethanol Exposure Impairs Trace Fear Conditioning and Alters NMDA Receptor Subunit Expression in Adult Male and Female Rats
ConclusionsEtOH‐induced changes in DH NMDAR subunit expression—particularly synaptic GluN2B, which is critical for TFC—are proposed to weaken long‐term memory consolidation and, during behavioral testing, diminish CS‐evoked freezing behavior. Cognitive dysfunction, including learning and memory, is a major feature of fetal alcohol spectrum disorders (FASD). Results of this study indicate that adult (5E) rats exposed to postnatal ethanol express significantly less GluN2B—a NMDA receptor subunit critical for associative learning—in hippocampal synaptic membrane fractions, impeding synaptic plasticity and long...
Source: Alcoholism: Clinical and Experimental Research - February 4, 2016 Category: Addiction Authors: Molly J. Goodfellow, Khalid A. Abdulla, Derick H. Lindquist Tags: Original Article Source Type: research

Clues to management of neonatally‐diagnosed BTK deficiency
This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - February 4, 2016 Category: Allergy & Immunology Authors: Angela Deyà‐Martínez, Ana Esteve‐Sole, Maria Teresa Giner, Juan I. Aróstegui, Estíbaliz Ruiz‐Ortiz, Jordi Yagüe, Manel Juan, Ana Maria Plaza, Laia Alsina Tags: Letter to the Editor Source Type: research

Double blind comparison of combination of 0.1% ropivacaine and fentanyl to combination of 0.1% bupivacaine and fentanyl for extradural analgesia in labour
Conclusions: Bupivacaine and ropivacaine provide equivalent analgesia in low (0.1%) concentration. (Source: Journal of Anaesthesiology Clinical Pharmacology)
Source: Journal of Anaesthesiology Clinical Pharmacology - February 4, 2016 Category: Anesthesiology Authors: Kishori Dhaku BawdaneJyoti S MagarBharati A Tendolkar Source Type: research

Pleural fluid accumulation detectable on paediatric post-mortem imaging: a possible marker of interval since death?
Conclusion The accumulation of pleural fluid detectable on PMMR in children is related to post-mortem interval. If this holds for a larger population, it may therefore be a useful marker for estimating time of death. A similar relationship was not found for perinatal deaths and stillbirths, the reasons for which remain uncertain. (Source: International Journal of Legal Medicine)
Source: International Journal of Legal Medicine - February 4, 2016 Category: Medical Law Source Type: research

Management of a woman with a previous spontaneous preterm birth
Preterm birth is an important cause of neonatal morbidity and mortality, and is associated with long term adverse health consequences. Worldwide close to 15 million babies are born preterm each year, and there are no signs that the rate of preterm birth is slowing. A history of a previous spontaneous preterm birth is a significant risk factor for a subsequent spontaneous preterm birth; identifying these women provides an opportunity to optimize care in future pregnancies. Interventions such as progesterone and cervical cerclage appear to be beneficial in women at high risk of preterm birth; however uncertainties remain as ...
Source: Obstetrics, Gynaecology and Reproductive Medicine - February 4, 2016 Category: OBGYN Authors: Charlotte Oyston, Katie Groom Tags: Review Source Type: research

Fetal infection: a pragmatic approach to recognition and management
Viruses and parasites can be transmitted from a pregnant woman to her fetus via the placenta and can affect development of the fetus. Maternal infection is often asymptomatic or mild. The implications for the fetus are dependent on gestation, stage of organogenesis, the presence of maternal immunity and the virus type. Fetal infections are a potentially preventable cause of perinatal morbidity and mortality. Prenatal diagnosis is often initiated due to exposure of mother to an infectious contact. (Source: Obstetrics, Gynaecology and Reproductive Medicine)
Source: Obstetrics, Gynaecology and Reproductive Medicine - February 4, 2016 Category: OBGYN Authors: Sarah Hamilton, Joanna Gillham Tags: Case-based learning Source Type: research

Neonatal Risk Factors for Treatment-Demanding Retinopathy of Prematurity
One goal of the study was to identify “new” statistically independent risk factors for treatment-demanding retinopathy of prematurity (ROP). Another goal was to evaluate whether any new risk factors could explain the increase in the incidence of treatment-demanding ROP over time in Denmark. (Source: Ophthalmology)
Source: Ophthalmology - February 4, 2016 Category: Opthalmology Authors: Carina Slidsborg, Aksel Jensen, Julie Lyng Forman, Steen Rasmussen, Regitze Bangsgaard, Hans Callø Fledelius, Gorm Greisen, Morten la Cour Source Type: research