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This page shows you the most recent publications within this specialty of the MedWorm directory.

The transverse diameter of the chest on routine radiographs reliably estimates gestational age and weight in premature infants
Conclusion An infant’s gestational age and birth weight can be reliably estimated by comparing a simple measurement of the transverse chest diameter on digital chest radiograph with the tables and graphs in our study. (Source: Pediatric Radiology)
Source: Pediatric Radiology - March 27, 2015 Category: Radiology Source Type: research

Gestational Diabetes: Screening, Management, Timing of Delivery
Abstract Gestational diabetes mellitus (GDM) is a pancreatic function insufficiency to overcome the insulin resistance associated with the pregnant state. The prevalence of GDM is about 2–5 % of normal pregnancies. To prevent the adverse outcome for the mother, the fetus, and neonatal period, detection of GDM is important. Screening methods vary by clinics. Screening can either be selective, based upon risk stratification or universal. Timely testing enables the obstetrician to assess glucose tolerance in the presence of the insulin-resistant state of pregnancy and permits treatment to begin before excessive fe...
Source: Current Obstetrics and Gynecology Reports - March 27, 2015 Category: OBGYN Source Type: research

[Editorial] Perinatal mental health—towards a robust system of care
The experiences of pregnancy and birth transform the lives of mothers and their families. Caring for children has the potential to enrich the lives of all involved, but accompanying health and social challenges are common. As discussed in a recent Lancet Series on perinatal mental health, perinatal depression, for example, occurs in an estimated 6·5–12·9% of mothers at different stages of pregnancy and during the year after birth. The financial costs of perinatal mental disorders, estimated at more than £8 billion in the UK for each annual cohort, are a scant reflection of their effect on the wellbeing of affected par...
Source: LANCET - March 27, 2015 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research

Op-Ed Contributor: Give Breast Milk
Donating breast milk should be more like donating blood. (Source: NYT Health)
Source: NYT Health - March 27, 2015 Category: Consumer Health News Authors: ELIZABETH CURRID-HALKETT Tags: Babies and Infants Pregnancy and Childbirth Premature Babies Parenting Milk Source Type: news

356) Voluntary wheel running reverses bladder hypersensitivity and dysfunction resulting from neonatal maternal separation in female mice
Exposure to early life stress serves as a risk factor for developing chronic pelvic pain disorders that have been attributed to altered functioning of the hypothalamic-pituitary-adrenal (HPA) axis, which regulates stress response and influences the perception of pain. Voluntary exercise has been shown to attenuate molecular and behavioral changes associated with a dysfunctional HPA axis; however, the potential therapeutic benefit of exercise on early life stress-induced adult visceral hypersensitivity has not been determined. (Source: The Journal of Pain)
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: A. Pierce, R. Wang, J. Ryals, J. Christianson Source Type: research

(357) Hypothalamic-pituitary-adrenal axis activation drives cross-sensitization following neonatal vaginal irritation in mice
Experiencing early life stress or injury increases the likelihood of developing chronic pelvic pain syndromes and concomitant dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. This has been well-described in both the gastrointestinal and urinary systems and here we provide additional evidence that reproductive organs are also susceptible to early life insult. To investigate the outcome of neonatal irritation of the vagina (NVI), female mouse pups were administered intravaginal zymosan on postnatal days 8 and 10 and assessed as adults for vaginal hypersensitivity; expression of transient receptor potential ank...
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: J. Christianson, A. Pierce, I. Fuentes, Z. Zhang, R. Wang, J. Ryals Source Type: research

(358) The impact of early or late voluntary exercise interventions on early life stress-induced comorbid mood and urogenital pain disorders in male mice
Exposure to adverse childhood events serves as a risk factor for mood and functional pain disorders due to alterations within the hypothalamic-pituitary-adrenal (HPA) axis, which regulates the response to stress and influences pain perception. Exercise in the clinical setting has a demonstrated beneficial impact on depression and anxiety, as well as decreased associated perceptions of pain. Here we have investigated the impact of 4-8 weeks of voluntary wheel running on behavioral indicators of depression, pelvic organ sensitivity, and micturition in male mice subjected to neonatal maternal separation (NMS). (Source: The Journal of Pain)
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: I. Fuentes, A. Pierce, R. Wang, J. Christianson Source Type: research

(360) Pudendal nerve stimulation inhibits visceromotor responses to urinary bladder distension during concurrent treatment with acute or chronic morphine
Bilateral electrical pudendal nerve stimulation (bPNS) anecdotally reduces pain in humans with pain due to interstitial cystitis (IC) and we have reported that it reduces bladder hypersensitivity in rat models. Concomitant medication use can alter responses to neuromodulation and so prior to the development of a clinical trial, the interaction between opioid medication use and acute bPNS was examined. Bladder hypersensitivity was produced by neonatal bladder inflammation in rats pups coupled with a second inflammatory insult as an adult. (Source: The Journal of Pain)
Source: The Journal of Pain - March 27, 2015 Category: Materials Science Authors: T. Ness, A. Randich, B. Clodfelder-Miller, J. McNaught, D. Nelson, X. Su Source Type: research

Distinct Testicular Steroidogenic Response Mechanisms Between Neonatal and Adult Heat-Acclimated Male Rats
Conclusion: Our data revealed that despite the similar steroid levels in plasma and secreted in vitro by neonatal and adult heat-acclimated rat testicular slices, the molecular mechanisms underlying the steroidogenic response to heat acclimation during these different developmental stages were distinct.Cell Physiol Biochem 2015;35:1729-1743 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - March 27, 2015 Category: Cytology Source Type: research

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons
Publication date: Available online 26 March 2015 Source:Cell Reports Author(s): Jonathan Gilley , Giuseppe Orsomando , Isabel Nascimento-Ferreira , Michael P. Coleman SARM1 function and nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) loss both promote axon degeneration, but their relative relationship in the process is unknown. Here, we show that NMNAT2 loss and resultant changes to NMNAT metabolites occur in injured SARM1-deficient axons despite their delayed degeneration and that axon degeneration specifically induced by NMNAT2 depletion requires SARM1. Strikingly, SARM1 deficiency also corrects axon outgr...
Source: Cell Reports - March 27, 2015 Category: Cytology Source Type: research

Neonatal Levels of T-cell Receptor Excision Circles (TREC) in Patients with 22q11.2 Deletion Syndrome and Later Disease Features
Conclusion The low TREC values not only correlate with decreased T-cell immunity, but also with the occurrence of heart defects in the patients. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - March 27, 2015 Category: Allergy & Immunology Source Type: research

Perinatal mental health—towards a robust system of care
Publication date: 28 March–3 April 2015 Source:The Lancet, Volume 385, Issue 9974 Author(s): The Lancet (Source: The Lancet)
Source: The Lancet - March 27, 2015 Category: Journals (General) Source Type: research

Immediate delivery versus expectant monitoring for hypertensive disorders of pregnancy between 34 and 37 weeks of gestation (HYPITAT-II): an open-label, randomised controlled trial
This study is registered with the Netherlands Trial Register (NTR1792). Findings Between March 1, 2009, and Feb 21, 2013, 897 women were invited to participate, of whom 703 were enrolled and randomly assigned to immediate delivery (n=352) or expectant monitoring (n=351). The composite adverse maternal outcome occurred in four (1·1%) of 352 women allocated to immediate delivery versus 11 (3·1%) of 351 women allocated to expectant monitoring (relative risk [RR] 0·36, 95% CI 0·12–1·11; p=0·069). Respiratory distress syndrome was diagnosed in 20 (5·7%) of 352 neonates in the immediate delivery group versus six (1·7%...
Source: The Lancet - March 27, 2015 Category: Journals (General) Source Type: research

Depression and anxiety during pregnancy and the postpartum period in women with epilepsy: A review of frequency, risks and recommendations for treatment
Conclusion Peripartum depression is frequent in WWE and seldom medically treated. Health personnel should screen WWE for psychiatric disease and risk factors during pre-pregnancy planning, pregnancy and postpartum follow up. Treatment decisions should rely on efficacy and safety data in peripartum patients without epilepsy and non-pregnant people with epilepsy. Consequences of in utero exposure to AED therapy in combination with antidepressants are not known, and non-pharmacological treatment should be tried first. (Source: Seizure)
Source: Seizure - March 27, 2015 Category: Neurology Source Type: research

Comparing type 1 and type 2 diabetes in pregnancy- similar conditions or is a separate approach required?
Conclusions: Pregnancy outcomes in T1DM and T2DM are different and occur at different levels of glycemia. This should be considered when planning and managing pregnancy and when counseling women. (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - March 27, 2015 Category: OBGYN Authors: Lisa OwensJon SedarLouise CarmodyFidelma Dunne Source Type: research

Accès des sages-femmes libérales au plateau technique : l’expérimentation d’une maternité de type 1
Discussion et conclusion L’accès au plateau technique apparaît comme une opportunité permettant à la sage-femme libérale de nouer une relation privilégiée avec sa patiente. Ce dispositif préserve toutefois la possibilité d’une prise en charge traditionnelle hospitalière en cas de nécessité. En ce sens, l’accès au plateau technique est une alternative sûre qui a l’assentiment des patientes, des sages-femmes comme de l’ensemble de notre équipe hospitalière. Ce dispositif a par ailleurs permis un surcroît d’activité obstétricale de 5 % par an pour notre service et laisse présager un gain de 10...
Source: Gynecologie Obstetrique and Fertilite - March 27, 2015 Category: OBGYN Source Type: research

Social equity in perinatal survival: a case–control study at hospitals in Kigali, Rwanda
ConclusionLiving in a rural area and having no health insurance were associated with an increased risk of perinatal mortality rates in the Rwandan capital, but maternal education and household assets were not. (Source: Acta Paediatrica)
Source: Acta Paediatrica - March 27, 2015 Category: Pediatrics Authors: Aimable Musafili, Birgitta Essén, Cyprien Baribwira, Katarina Ekholm Selling, Lars‐Åke Persson Tags: Regular Article Source Type: research

White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage
Neural crest cells (NCCs) emerge from the dorsal region of the neural tube of vertebrate embryos and have the pluripotency to differentiate into both neuronal and non‐neuronal lineages including melanocytes. Rest, also known as NRSF (neuro‐restrictive silencer factor), is a regulator of neuronal development and function and suggested to be involved in the lineage specification of NCCs. However, further investigations of Rest gene functions in vivo have been hampered by the fact that Rest null mice show early embryonic lethality. To investigate the function of Rest in NCC development, we recently established NCC‐speci...
Source: Genes to Cells - March 27, 2015 Category: Genetics & Stem Cells Authors: Hitomi Aoki, Akira Hara, Takahiro Kunisada Tags: Original Article Source Type: research

pH Regulation in Astrocytes [Cell Biology]
The mechanisms of HCO3−-independent intracellular pH (pHi) regulation were examined in fibrous astrocytes within isolated neonatal rat optic nerve (RON) and in cultured cortical astrocytes. In agreement with previous studies, resting pHi in cultured astrocytes was 6.82 ± 0.06 and inhibition of the V-ATPase H+ pump by Cl− removal or via the selective inhibitor bafilomycin had only a small effect upon resting pHi and recovery following an acid load. In contrast, resting pHi in RON astrocytes was 7.10 ± 0.04, significantly less acidic than that in cultured cells (p < 0.001), and responded to inhibition of V-ATPase with ...
Source: Journal of Biological Chemistry - March 27, 2015 Category: Chemistry Authors: Hansen, D. B., Garrido-Comas, N., Salter, M., Fern, R. Tags: Neurobiology Source Type: research

Receptor Binding by F4 Fimbriae [Molecular Bases of Disease]
Enterotoxigenic Escherichia coli (ETEC) strains are important causes of intestinal disease in humans and lead to severe production losses in animal farming. A range of fimbrial adhesins in ETEC strains determines host and tissue tropism. ETEC strains expressing F4 fimbriae are associated with neonatal and post-weaning diarrhea in piglets. Three naturally occurring variants of F4 fimbriae (F4ab, F4ac, and F4ad) exist that differ in the primary sequence of their major adhesive subunit FaeG, and each features a related yet distinct receptor binding profile. Here the x-ray structure of FaeGad bound to lactose provides the firs...
Source: Journal of Biological Chemistry - March 27, 2015 Category: Chemistry Authors: Moonens, K., Van den Broeck, I., De Kerpel, M., Deboeck, F., Raymaekers, H., Remaut, H., De Greve, H. Tags: Microbiology Source Type: research

Neonatal Streptococcus pneumoniae Infection May Aggravate Adulthood Allergic Airways Disease in Association with IL-17A
by Baohui Yang, Ru Liu, Ting Yang, Xiaoli Jiang, Liqun Zhang, Lijia Wang, Qinghong Wang, Zhengxiu Luo, Enmei Liu, Zhou Fu Epidemiologic studies have demonstrated that some bacteria colonization or infections in early-life increased the risk for subsequent asthma development. However, little is known about the mechanisms by which early-life bacterial infection increases this risk. The aim of this study was to investigate the effect of neonatal Streptococcus pneumoniae infection on the development of adulthood asthma, and to explore the possible mechanism. A non-lethal S. pneumoniae lung infection was established by intrana...
Source: PLoS One - March 27, 2015 Category: Biomedical Science Authors: Baohui Yang et al. Source Type: research

Neonatal Androgenization-Induced Early Endocrine-Metabolic and Ovary Misprogramming in the Female Rat
Publication date: Available online 26 March 2015 Source:Life Sciences Author(s): Luisina Ongaro , Natalia R. Salvetti , Andrés Giovambattista , Eduardo Spinedi , Hugo H. Ortega Aim Androgen excess predisposes the organism to develop metabolic-endocrine and reproductive dysfunctions, among them the development of a phenotype resembling that of human Polycystic Ovary Syndrome (PCOS). Methods We analyzed the impact of a single neonatal (5 day-old) testosterone propionate (TP; s.c. 1.25 mg/female pup) dose on: a) several metabolic-endocrine activities and b) ovarian steroidogenic and granulosa cell (GC) functions and also ...
Source: Life Sciences - March 27, 2015 Category: Biology Source Type: research

A case of maternal vitamin k deficiency associated with hyperemesis gravidarum: its potential impact on fetal blood coagulability.
We describe a pregnant woman with vitamin K deficiency possibly due to hyperemesis gravidarum. The patient was treated for the deficiency, and no fetal or neonatal hemorrhagic diseases were manifested. PMID: 25797877 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Shigemi D, Nakanishi K, Miyazaki M, Shibata Y, Suzuki S Tags: J Nippon Med Sch Source Type: research

Clinical characteristics of pregnancies with a history of recurrent miscarriage at a Japanese perinatal center.
CONCLUSION: The pregnancy of women with a history of recurrent miscarriage is not associated with adverse outcomes at our perinatal center. PMID: 25797873 [PubMed - in process] (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - March 26, 2015 Category: Universities & Medical Training Authors: Terada K, Nakanishi K, Suzuki S Tags: J Nippon Med Sch Source Type: research

Do antibiotics in pregnancy cause cerebral palsy and epilepsy?
ConclusionThe findings from this large study indicate that antibiotic use in pregnancy was not associated with an increased risk of cerebral palsy or epilepsy. The apparent increased risk of macrolides compared with penicillin is not reliable. A direct comparison between the women taking each type of antibiotic is inaccurate, as it does not take into account potential confounding factors. These include: the type and severity of the infections, which could have affected the baby, rather than the antibiotic whether the women took all of the course of antibiotic or not as a result of side effects; if stopped early, the i...
Source: NHS News Feed - March 26, 2015 Category: Consumer Health News Tags: Medication Pregnancy/child Source Type: news

Short-term survival of hyperammonemic neonates treated with dialysis
Conclusions In this study, a delayed ECD treatment was not superior to PD in improving the short-term outcome of neonates with hyperammonemia secondary to IEM. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - March 26, 2015 Category: Urology & Nephrology Source Type: research

True Knot of the Umbilical Cord—3D Power Doppler Imaging
(Source: Journal of Fetal Medicine)
Source: Journal of Fetal Medicine - March 26, 2015 Category: Perinatology & Neonatology Source Type: research

Effect of Megasphaera elsdenii NCIMB 41125 dosing on rumen development, volatile fatty acid production and blood β‐hydroxybutyrate in neonatal dairy calves
Summary Thirty calves were randomly assigned to two treatments and fed until weaning [42 days (d) of age]. Treatments were a control group (n = 15), which did not receive Megasphaera elsdenii (Me0) and a M. elsdenii group, which received a 50‐ml oral dose of M. elsdenii NCIMB 41125 (108 CFU/ml) at day 14 day of age (Me14). Calves were given colostrum for the first 3 day followed by limited whole milk feeding. A commercial calf starter was offered ad libitum starting at day 4 until the end of the study. Fresh water was available throughout the study. Feed intake and growth were measured. Blood samples were collect...
Source: Journal of Animal Physiology and Animal Nutrition - March 26, 2015 Category: Zoology Authors: M. C. Muya, F. V. Nherera, K. A. Miller, C. C. Aperce, P. M. Moshidi, L. J. Erasmus Tags: Original Article Source Type: research

Perinatal exposure to low-dose of bisphenol A causes anxiety-like alteration in adrenal axis regulation and behaviors of rat offspring: A potential role for metabotropic glutamate 2/3 receptors
Conclusion Our data demonstrate for the first time that the perinatal BPA exposure induces an anxiety-like phenotype in behaviors and -related neuroendocrinology, and suggest that the changes in mGlu2/3 receptor might lie at the core of the pathological reprogramming triggered by early-life adversity. mGlu2/3 receptor may serve as a novel biomarker and potential therapeutic target for anxiety disorders associated with adverse early-life agents including perinatal BPA exposure. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - March 26, 2015 Category: Psychiatry Source Type: research

Neonatal effect of remifentanil in general anaesthesia for caesarean section: a randomized trial
Conclusion: At a dose of 1 μg/kg, remifentanil prior to induction of general anaesthesia increases the risk of neonatal respiratory depression during first minutes after caesarean delivery but duration of clinical symptoms is short.Trial registrationClinicalTrials.gov: NCT01550640. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - March 26, 2015 Category: Anesthesiology Authors: Pavlina NoskovaJan BlahaHana BakhoucheJana KubatovaJitka UlrichovaPatricia MarusicovaJan SmisekAntonin ParizekOndrej SlanarPavel Michalek Source Type: research

The orphan receptor NOR1 participates in isoprenaline‐induced cardiac hypertrophy by regulating PARP‐1
Conclusions and ImplicationsThis is the first evidence that NOR1 was involved in isoprenaline‐induced cardiac hypertrophy. The pro‐hypertrophic effect of NOR1 can be partly attributed to its regulation of PARP‐1 enzymic activity. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - March 26, 2015 Category: Drugs & Pharmacology Authors: Xiao‐Jun Feng, Hui Gao, Si Gao, Zhuoming Li, Hong Li, Jing Lu, Jiao‐Jiao Wang, Xiao‐Yang Huang, Min Liu, Jian Zou, Jian‐Tao Ye, Pei‐Qing Liu Tags: RESEARCH PAPER Source Type: research

Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation
We evaluated the neurodevelopmental (ND) outcome at one year of age for congenital diaphragmatic hernia (CDH) children who have not undergone extracorporeal membrane oxygenation (ECMO) treatment during the neonatal period. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - March 26, 2015 Category: Surgery Authors: Enrico Danzer, Marsha Gerdes, Jo Ann D’Agostino, Judy Bernbaum, Casey Hoffman, Lisa Herkert, Natalie E. Rintoul, William H. Peranteau, Alan W. Flake, N. Scott Adzick, Holly L. Hedrick Source Type: research

Ghanaian midwifery students' perceptions and experiences of disrespect and abuse during childbirth
Publication date: March 2015 Source:The Lancet Global Health, Volume 3, Supplement 1 Author(s): S Rominski Background One strategy to reduce maternal and neonatal mortality in low-income and middle-income countries is to increase the rate of deliveries in health clinics and hospitals. However, reports of disrespect and abuse of women during birth are becoming common. When women are disrespected or abused during childbirth, they are less likely to choose facility-based births in the future. We did an exploratory qualitative study to investigate midwifery students' experiences and perceptions of how women are treated durin...
Source: The Lancet Global Health - March 26, 2015 Category: Global & Universal Source Type: research

Estimating indices of health system readiness: an example from rural northern Ghana
Publication date: March 2015 Source:The Lancet Global Health, Volume 3, Supplement 1 Author(s): C Boyer , E Jackson , A Bawah , M Schmitt , J Awoonor-Williams , J Phillips Background There is growing recognition that stronger health systems are necessary to accelerate progress towards the Millennium Development Goals (MDGs). However, a departure from disease-specific programmes and interventions requires the development of a new empirical framework for programme evaluation that focuses on indicators of health system strengthening. Service provision assessment (SPA) surveys provide a wealth of data about health system res...
Source: The Lancet Global Health - March 26, 2015 Category: Global & Universal Source Type: research

Correction
In the article, “Alterations in Brain Structure and Neurodevelopmental Outcome in Preterm Infants Hospitalized in Different Neonatal Intensive Care Unit Environments,” by Pineda et al, J Pediatr 2014;164:52-60, the authors inadvertently labeled the key backwards for Figure 2 (“left deeper” should have been on the left, and “right deeper” should have been on the right), which has been corrected below. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 25, 2015 Category: Pediatrics Tags: Correction Source Type: research

Research to investigate benefits of real time continuous glucose monitoring in neonatal intensive care
A new study funded by the Efficacy and Mechanism Evaluation (EME) Programme, an MRC and NIHR partnership, will examine whether real time continuous glucose monitoring in preterm infants could help clinicians to control blood sugar levels more easily.Nearly 60,000 babies are born prematurely in the UK every year. Babies born prematurely have a higher risk... (Source: NIHR Evaluation, Trials and Studies News)
Source: NIHR Evaluation, Trials and Studies News - March 25, 2015 Category: American Health Source Type: news

Does Caspase-6 Have a Role in Perinatal Brain Injury
We examined whether caspases are involved in microglial activation. We assessed cleaved caspase-6 expression following hypoxia-ischaemia and conducted primary microglial cultures to assess whether the broad-spectrum inhibitor Q-VD-OPh or caspase-6 gene deletion affected lipopolysaccharide (LPS)-mediated microglial activation and phenotype. We observed cleaved caspase-6 expression to be low but present in the cell body and cell processes in both a human case of white matter injury and 72 h following hypoxia-ischaemia in the rat. Gene deletion of caspase-6 did not affect the outcome of brain injury following mild (50 min) or...
Source: Developmental Neuroscience - March 25, 2015 Category: Neuroscience Source Type: research

Surveillance of healthcare-associated infections in a neonatal intensive care unit in Italy during 2006–2010
Conclusions: HAIs developed in all BW classes but low BW neonates were at major risk to acquire HAIs in our NICU. Use of central line-, umbilical-catheter and mechanical ventilation was associated with higher risk of infection. Our findings highlight the importance of an extensive surveillance approach in the NICU setting, which includes all BW classes of neonates and monitors infections associated with the use of medical devices. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - March 25, 2015 Category: Infectious Diseases Authors: Valeria CrivaroLidija Bogdanovi¿Maria BagattiniVita IulaMariarosaria CataniaFrancesco RaimondiMaria TriassiRaffaele Zarrilli Source Type: research

Literacy after cerebral hemispherectomy: Can the isolated right hemisphere read?
Conclusions When cerebral hemispherectomy is performed to control seizures associated with very early (in utero) insult, it has been found that the remaining right hemisphere is still able to support reading and phonological processing skills that are normally mediated by the left hemisphere. Our results also suggest the existence of variability in individuals after hemispherectomy, even within groups having the same etiology and similar timing of insult. (Source: Epilepsy and Behavior)
Source: Epilepsy and Behavior - March 25, 2015 Category: Neurology Source Type: research

The worldwide epidemic of female obesity
This article describes the extent and the cost of the obesity epidemic, which, although historically seen as a disease of high-income countries, is now clearly a global epidemic that impacts low- and middle-income countries and indigenous groups who bear an ever-increasing burden of this disease. (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - March 25, 2015 Category: OBGYN Source Type: research

Déroulement du travail : quelles définitions de la normalité ou de la dystocie ?
Publication date: Available online 25 March 2015 Source:Gynécologie Obstétrique &amp; Fertilité Author(s): G. Kayem Le déroulement du travail « normal » a été étonnamment peu étudié ces 60 dernières années alors qu’il s’agit d’un axe central en obstétrique. Des normes du déroulement du travail ont été proposées il y a 60ans par Emmanuel Friedman et adoptées par de nombreux pays pour devenir ensuite, sous l’impulsion de l’école de Dublin, des règles conditionnant la prise en charge du travail : rupture des membranes et ocytociques avec, en cas d’échec, césarienne pour dystocie d...
Source: Gynecologie Obstetrique and Fertilite - March 25, 2015 Category: OBGYN Source Type: research

Naissance d’un enfant porteur de trisomie 21 : choix parental ou défaut de la politique de dépistage ?
Conclusion Dans notre série, la naissance d’un enfant trisomique 21 fait suite à un choix parental dans la moitié des cas. Il est indispensable, pour optimiser la prise en charge des patientes, de tracer dans les dossiers médicaux l’information délivrée sur la T21 et, sur les données du dépistage quand il a été réalisé. Objectives Birth of a child with Down syndrome (DS) can follow parental choice or failure of screening. The objective of this work is to describe the circumstances of births of children with DS in a French perinatal health network. Methods Retrospective multicentric study, with prospecti...
Source: Gynecologie Obstetrique and Fertilite - March 25, 2015 Category: OBGYN Source Type: research

Correlation between umbilical cord hemoglobin and rate of jaundice requiring phototherapy in healthy newborns
ConclusionsHigher cord hemoglobin may increase neonatal jaundice in newborns in Japan, therefore the present results support the Japan Resuscitation Council guideline 2010, which does not recommend delay of umbilical cord clamping by at least 1 min, in contrast to the ILCOR guidelines. (Source: Pediatrics International)
Source: Pediatrics International - March 25, 2015 Category: Pediatrics Authors: Machiko Nakagawa, Yasushi Ishida, Yuko Nagaoki, Hidenobu Ohta, Rinshu Shimabukuro, Michio Hirata, Michiko Yamanaka, Isao Kusakawa Tags: Original Article Source Type: research

Suspected fetal onset of neonatal transient eosinophilic colitis and development of respiratory distress
Abstract Neonatal transient eosinophilic colitis (NTEC) is a new disease concept within eosinophilic gastroenteritis, which was proposed by Ohtsuka et al. It causes hematochezia as a result of eosinophilia, in neonates who have not yet started to receive enteral nutrition, although the whole‐body status of the infant is in fact relatively good. To date, there have been no reports of this disease in which abnormalities were noted during gestation, and the clinical phenomena surrounding it, along with any complications, are not yet clear. We encountered a suspected case of NTEC causing respiratory distress with aspiratio...
Source: Pediatrics International - March 25, 2015 Category: Pediatrics Authors: Katsunori Tanaka, Shigeki Koshida, Takahide Yanagi, Hidemi Tsutsui, Sayuri Nakahara, Ouki Furukawa, Shunichiro Tsuji Tags: Patient Report Source Type: research

Outcome comparison of very preterm infants cared for in the neonatal intensive care units in Australia and New Zealand and in Canada
ConclusionsDespite similarities in settings, ANZNN infants fared better in most measures. Outcome disparities may be related to differences in tertiary service provision, referral and clinical practices. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - March 25, 2015 Category: Pediatrics Authors: Sadia Hossain, Prakesh S Shah, Xiang Y Ye, Brian A Darlow, Shoo K Lee, Kei Lui, , Tags: Original Article Source Type: research

Impact of the systematic introduction of low-cost bubble nasal CPAP in a NICU of a developing country: a prospective pre- and post-intervention study
Background: The use of Nasal Continuous Positive Airway Pressure Ventilation (NCPAP) has begun to increase and is progressively replacing conventional mechanical ventilation (MV), becoming the cornerstone treatment for newborn respiratory distress syndrome (RDS). Howerver, NCPAP use in Lower-Middle Income Countries (LMICs) is poor. Moreover, bubble NCPAP (bNCPAP), for efficacy, cost effectiveness, and ease of use, should be the primary assistance technique employed in newborns with RDS.Objective: To measure the impact on in-hospital newborn mortality of using a bNCPAP device as the first intervention on newborns requiring ...
Source: BMC Pediatrics - March 25, 2015 Category: Pediatrics Authors: Rossano RezzonicoLetizia CaccamoValeria ManfrediniMassimo CartabiaNieves SanchezZoraida ParedesPatrizia FroeschFranco CavalliMaurizio Bonati Source Type: research

Re-Evaluating “Transitional Neonatal Hypoglycemia”: Mechanism and Implications for Management
A Committee of the Pediatric Endocrine Society was recently formed to develop guidelines for evaluation and management of hypoglycemia in neonates, infants, and children. To aid in formulating recommendations for neonates, in this review, we analyzed available data on the brief period of hypoglycemia, which commonly is observed in normal newborns during the transition from fetal to extrauterine life, hereafter referred to as transitional neonatal hypoglycemia in normal newborns. The goal was to better understand the mechanism underlying this phenomenon in order to formulate recommendations for recognizing neonates requirin...
Source: The Journal of Pediatrics - March 25, 2015 Category: Pediatrics Authors: Charles A. Stanley, Paul J. Rozance, Paul S. Thornton, Diva D. De Leon, Deborah Harris, Morey W. Haymond, Khalid Hussain, Lynne L. Levitsky, Mohammad H. Murad, Rebecca A. Simmons, Mark A. Sperling, David A. Weinstein, Neil H. White, Joseph I. Wolfsdorf Tags: Commentary Source Type: research

Giant Omphaloceles: Surgical Management and Perinatal Outcomes
The purpose of this study was to describe the current management and outcomes of infants with omphalocele. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - March 25, 2015 Category: Surgery Authors: Adesola C. Akinkuotu, Fariha Sheikh, Oluyinka O. Olutoye, Timothy C. Lee, Cariciolo J. Fernandes, Stephen E. Welty, Nancy A. Ayres, Darrell L. Cass Source Type: research

Preterm patent ductus arteriosus: A continuing conundrum for the neonatologist?
How to manage the preterm patent ductus arteriosus (PDA) remains a conundrum. On the one hand, physiology and statistical association with adverse outcomes suggest that it is pathological. On the other hand, clinical trials of treatment strategies have failed to show any long-term benefit. Ultrasound studies of PDA have suggested that the haemodynamic impact may be much earlier after birth than previously thought (in the first hours); however, we still do not know when to treat PDA. Studies that have tested symptomatic or pre-symptomatic treatment are mainly historical and have not tested the effect of no treatment. (Sourc...
Source: Seminars in Fetal and Neonatal Medicine - March 25, 2015 Category: Perinatology & Neonatology Authors: Nick Evans Tags: Review Source Type: research