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Perinatology & Neonatology

This page shows you the most recent publications within this specialty of the MedWorm directory.

Effect of 17β-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats.
In conclusion, in male rats, the administration of estrogen further enhanced the impairment of dopaminergic transmission due to exposure to permethrin. PMID: 25048945 [PubMed - in process] (Source: Chemosphere)
Source: Chemosphere - July 26, 2014 Category: Chemistry Authors: Nasuti C, Carloni M, Fedeli D, Di Stefano A, Marinelli L, Cerasa LS, Meda C, Maggi A, Gabbianelli R Tags: Chemosphere Source Type: research

Brief report novel mechanism for valproate‐induced teratogenicity
Conclusion: If these data translate to the overall transport and subsequent bioavailability of folates, noncompetitive inhibition of the folate receptors by VPA may serve to lower the bioavailable folates in VPA treated mothers. This represents a novel mechanism by which in utero VPA exposure could be disrupting developmental processes by noncompetitively binding to the folate receptors during embryogenesis, thus inducing the wide range of defects seen in babies born to VPA treated mothers. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 26, 2014 Category: Perinatology & Neonatology Authors: Kristin Fathe, Ana Palacios, Richard H. Finnell Tags: Brief Report Source Type: research

[Department of Error] Department of Error
Bhutta Z, Das JK, Bahl R, et al, for The Lancet Every Newborn Study Group. Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost? Lancet 2014; published online May 20. http://dx.doi.org/10.1016/S0140-6736(14)60792-3—In this Series paper, the author “Jeeva M Sankar” should have read “M Jeeva Sankar”. Also, the second sentence of the summary should have read “To meet Every Newborn targets of ten or fewer neonatal deaths and ten or fewer stillbirths per 1000 births in every country by 2035…”. (Source: LANCET)
Source: LANCET - July 26, 2014 Category: Journals (General) Authors: The Lancet Tags: Department of Error Source Type: research

[Series] Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost?
Progress in newborn survival has been slow, and even more so for reductions in stillbirths. To meet Every Newborn targets of ten or fewer neonatal deaths and ten or fewer stillbirths per 1000 births in every country by 2035 will necessitate accelerated scale-up of the most effective care targeting major causes of newborn deaths. We have systematically reviewed interventions across the continuum of care and various delivery platforms, and then modelled the effect and cost of scale-up in the 75 high-burden Countdown countries. (Source: LANCET)
Source: LANCET - July 26, 2014 Category: Journals (General) Authors: Zulfiqar A Bhutta, Jai K Das, Rajiv Bahl, Joy E Lawn, Rehana A Salam, Vinod K Paul, M Jeeva Sankar, Hannah Blencowe, Arjumand Rizvi, Victoria B Chou, Neff Walker, for The Lancet Newborn Interventions Review Group , The Lancet Every Newborn Study Group Tags: Series Source Type: research

Analysis of chromosomal structural variation in patients with congenital left‐sided cardiac lesions
Conclusion: This study examines the largest cohort to date with LSCD for structural variation. These data suggest that CNVs play a role in disease risk and identify numerous genes disrupted by CNVs of potential disease relevance. These findings further highlight the genetic heterogeneity and complexity of these disorders. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 26, 2014 Category: Perinatology & Neonatology Authors: Peter S. White, Hongbo M. Xie, Petra Werner, Joseph Glessner, Brande Latney, Hakon Hakonarson, Elizabeth Goldmuntz Tags: Original Research Article Source Type: research

Dietary folate intake levels in rural women immediately before pregnancy in Northern China
ConclusionDietary folate intake among study participants was far below the recommended intake level. Folic acid fortification of cereals is advised to raise folate intake in rural Chinese women planning to become pregnant. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 26, 2014 Category: Perinatology & Neonatology Authors: Qinqin Meng, Le Zhang, Jufen Liu, Zhiwen Li, Lei Jin, Yali Zhang, Linlin Wang, Aiguo Ren Tags: Original Research Article Source Type: research

Frequency of dosage prescribing medication errors associated with manual prescriptions for very preterm infants
This study aimed to evaluate the rate of dosage PME related to manual prescriptions in the high‐risk population of very preterm infants (GA < 33 weeks) in a mixed prescription system. MethodsThe study was based on a retrospective review of a random sample of manual daily prescriptions in two neonatal intensive care units (NICU) A and B, located in different French University hospitals (Dijon and La Reunion island). Daily prescription was defined as the set of all drugs manually prescribed on a single day for one patient. Dosage error was defined as a deviation of at least ±10% from the weight‐appropriate recomme...
Source: Journal of Clinical Pharmacy and Therapeutics - July 25, 2014 Category: Drugs & Pharmacology Authors: J. Horri, A. Cransac, C. Quantin, M. Abrahamowicz, C. Ferdynus, C. Sgro, P.‐Y. Robillard, S. Iacobelli, J.‐B. Gouyon Tags: Original Article Source Type: research

A Black Woman's Commentary on Breastfeeding
Breastfeeding Medicine , Vol. 0, No. 0. (Source: Breastfeeding Medicine)
Source: Breastfeeding Medicine - July 25, 2014 Category: Perinatology & Neonatology Tags: article Source Type: research

Title Page/Aims and Scope/Editorial Board
(Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - July 25, 2014 Category: Perinatology & Neonatology Source Type: research

Influence of iodization programmes on the epidemiology of nodular goitre.
Abstract Iodine is essential for the synthesis of thyroid hormones. Iodine deficiency can affect human health in different ways, and is commonly referred to as iodine deficiency disorders (IDD). These range from defective development of the central nervous system during the fetal-neonatal life, to goitre in the adult. Only a few countries were completely iodine sufficient before 1990. Since then, a major effort has been made to introduce salt iodization to ensure sufficient intake of iodine in deficient areas. Iodine prophylaxis has been shown to exert a pivotal role in abating goitre and other iodine-deficiency di...
Source: Clin Med Res - July 25, 2014 Category: Research Authors: Fiore E, Tonacchera M, Vitti P Tags: Best Pract Res Clin Endocrinol Metab Source Type: research

Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation
A multitude of factors regulate oligodendrocyte differentiation and remyelination, and to elucidate the mechanisms underlying this process, we analyzed the interactions of known signaling pathways involved in these processes. Previous work from our lab and others shows that Akt, mTOR, and Erk 1/2 are major signaling pathways regulating oligodendrocyte differentiation and myelination in vitro and in vivo. However, the relative contribution of the different pathways has been difficult to establish because the impact of inhibiting one pathway in in vitro cell culture models or in vivo may alter signaling through the other pat...
Source: Glia - July 25, 2014 Category: Neurology Authors: JinXiang Dai, Kathryn K. Bercury, Wendy B. Macklin Tags: Research Article Source Type: research

Fcγ Receptors III and IV Mediate Tissue Destruction in a Novel Adult Mouse Model of Bullous Pemphigoid.
Abstract Bullous pemphigoid (BP) and epidermolysis bullosa acquisita are subepidermal autoimmune blistering diseases mediated by autoantibodies against type XVII collagen (Col17) and Col7, respectively. For blister formation, Fc-mediated events, such as infiltration of inflammatory cells in the skin, complement activation, and release of proteases at the dermal-epidermal junction, are essential. Although in the neonatal passive transfer mouse model of BP, tissue destruction is mediated by Fcγ receptors (FcγRs) I and III, the passive transfer model of epidermolysis bullosa acquisita completely depends on FcγRIV. ...
Source: The American Journal of Pathology - July 25, 2014 Category: Pathology Authors: Schulze FS, Beckmann T, Nimmerjahn F, Ishiko A, Collin M, Köhl J, Goletz S, Zillikens D, Ludwig R, Schmidt E Tags: Am J Pathol Source Type: research

Neonatal jaundice and increased risk of attention‐deficit hyperactivity disorder: a population‐based cohort study
ConclusionNeonates with jaundice are at high risk for developing physician‐diagnosed ADHD during their growth period. A risk alert regarding neurologic consequences is urgently required after a neonatal jaundice diagnosis. Additional studies should be conducted to clarify the pathogenesis of these relationships. (Source: Journal of Child Psychology and Psychiatry)
Source: Journal of Child Psychology and Psychiatry - July 25, 2014 Category: Psychiatry Authors: Chang‐Ching Wei, Chun‐Hung Chang, Cheng‐Li Lin, Shih‐Ni Chang, Tsai‐Chung Li, Chia‐Hung Kao Tags: Original Article Source Type: research

Practice Bulletin No. 146: Management of Late-Term and Postterm Pregnancies.
Authors: Abstract Postterm pregnancy refers to a pregnancy that has reached or extended beyond 42 0/7 weeks of gestation from the last menstrual period (LMP), whereas a late-term pregnancy is defined as one that has reached between 41 0/7 weeks and 41 6/7 weeks of gestation (). In 2011, the overall incidence of postterm pregnancy in the United States was 5.5% (). The incidence of postterm pregnancies may vary by population, in part as a result of differences in regional management practices for pregnancies that go beyond the estimated date of delivery. Accurate determination of gestational age is essential to accu...
Source: Obstetrics and Gynecology - July 25, 2014 Category: OBGYN Tags: Obstet Gynecol Source Type: research

A Systematic Review of Amniotic Fluid Assessments in Twin Pregnancies
The objectives of this systematic review were to examine the reproducibility of sonographic estimates of amniotic fluid volume (AFV) in twin pregnancies, compare the association of sonographic estimates of AFV with dye-determined AFV, and correlate AFV with antepartum, intrapartum, and perinatal outcomes in twin pregnancies. Studies were included if they were adequately powered and investigated antepartum, intrapartum, and/or perinatal adverse outcome parameters in twin gestations. Studies with comparable populations and exclusion criteria were merged into forest plots. Data comparing the accuracy of AFV assessment, correl...
Source: Journal of Ultrasound in Medicine - July 25, 2014 Category: Radiology Authors: Ippolito, D. L., Bergstrom, J. E., Lutgendorf, M. A., Flood-Nichols, S. K., Magann, E. F. Tags: Review Articles Source Type: research

Neonatal transport in resource restricted settings: a simple clinical score at arrival and its role in predicting mortality
No description available (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - July 25, 2014 Category: Epidemiology Authors: Deepak RathodBethou AdhisivamVishnu Bhat Source Type: research

Clinical characteristics of monochorionic twins with large hemoglobin level discordance at birth
ConclusionsAlthough the incidence of TAPS and AFFH may be low in MCDA twins, many affected neonates required treatment for hematological abnormalities. Delivery of MCDA twins via Cesarean section does not appear to prevent AFFH, despite the absence of labor. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - July 25, 2014 Category: Radiology Authors: A. Mabuchi, K. Ishii, R. Yamamoto, T. Taguchi, M. Murata, S. Hayashi, N. Mitsuda Tags: Original Article Source Type: research

The effects of olfactory stimulation and gender differences on pain responses in full‐term infants
ConclusionCrying and finger splaying/fisting were observable responses that may be useful for screening pain or distress in healthy neonates. Increased pain reactions by boys may reflect higher irritability. Exposure to an unfamiliar odour did not have a calming effect on full‐term neonates.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 25, 2014 Category: Pediatrics Authors: Olga Romantsik, H Porter Richard, Heili Varendi Tags: Regular Article Source Type: research

The effect of facilitated tucking on procedural pain control among premature babies
ConclusionsFacilitated tucking reduced the Premature Infant Pain Profile scores in preterm infants. Relevance to clinical practiceThe findings of this study suggest that facilitated tucking is able to alleviate pain; therefore, nurses must be able to carry out facilitated tucking when necessary. (Source: Journal of Clinical Nursing)
Source: Journal of Clinical Nursing - July 24, 2014 Category: Nursing Authors: Olive Lopez, Pathmawathi Subramanian, Norsiah Rahmat, Lim Chin Theam, Karuthan Chinna, Roshaslina Rosli Tags: Original Article Source Type: research

Standardizing morphine use for ventilated preterm neonates with a nursing-driven comfort protocol
Mangione-Smith (Source: Journal of Perinatology)
Source: Journal of Perinatology - July 24, 2014 Category: Perinatology & Neonatology Authors: R FleishmanC ZhouC GleasonC LarisonM T MyaingR Mangione-Smith Source Type: research

CLIC1 functional expression is required for cAMP‐induced neurite elongation in postnatal mouse retinal ganglion cells
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 24, 2014 Category: Neurology Authors: Stefania Averaimo, Marta Gritti, Erica Barini, Laura Gasparini, Michele Mazzanti Tags: Original Article Source Type: research

Prediction of IVIG treatment efficiency in fetal/neonatal alloimmune thrombocytopenia
(Source: Blood)
Source: Blood - July 24, 2014 Category: Hematology Authors: Bertrand, G., Petermann, R., Kaplan, C. Tags: Pediatric Hematology, Thrombocytopenia, Free Research Articles, Platelets and Thrombopoiesis, Clinical Trials and Observations CORRESPONDENCE Source Type: research

Critical congenital heart disease screening by pulse oximetry in a neonatal intensive care unit
minrusimha (Source: Journal of Perinatology)
Source: Journal of Perinatology - July 24, 2014 Category: Perinatology & Neonatology Authors: V ManjaB MathewV CarrionS Lakshminrusimha Source Type: research

Maternal anti-D prophylaxis during pregnancy and risk of hemolysis among preterm infants
p; T Strauss (Source: Journal of Perinatology)
Source: Journal of Perinatology - July 24, 2014 Category: Perinatology & Neonatology Authors: A Maayan-MetzgerL LeibovitchI Schushan-EisenI MoragT Strauss Source Type: research

Critical congenital heart disease screening by pulse oximetry in a neonatal intensive care unit
minrusimha (Source: Journal of Perinatology)
Source: Journal of Perinatology - July 24, 2014 Category: Perinatology & Neonatology Authors: V ManjaB MathewV CarrionS Lakshminrusimha Source Type: research

Hemolytic disease of fetus and newborn due to maternal red blood cell alloantibodies in the Malay population
Conclusions: With the low prevalence of clinically significant RBC alloantibodies and HDFN, routine antenatal antibody screening practice may not be advised as a routine practice at present, preferably reserved for those women of RhD negative or with history of HDFN, significantly of those attributed to anti-c. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 24, 2014 Category: Hematology Authors: Mohd Nazri HassanNoor Haslina Mohd NoorShah Reza Johan NoorSalamah Ahmad SukriRapiaah MustafaHans Van Rostenberghe Luc Aster Source Type: research

In search of neural endophenotypes of postpartum psychopathology and disrupted maternal caregiving
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - July 24, 2014 Category: Endocrinology Authors: EL Moses‐Kolko, Horner, ML Phillips, AE Hipwell, JE Swain Tags: Review Article Source Type: research

The use of ultrasound‐guided regional anaesthetic techniques in neonates and young infants
Optimal pain therapy during the perioperative period or at the neonatal intensive care unit and subsequent reduced use of opioids and various sedative drugs is an important factor for patients care. The use of various regional anaesthetic techniques in experienced hands provides excellent pain relief and has the potency to reduce the requirement for perioperative mechanical ventilation. Most of regional anaesthesia techniques are applicable also in neonates and young infants and can be used in an effective and safe manner. Ultrasound guidance should be used for all regional anaesthetic techniques to increase efficacy and s...
Source: Acta Anaesthesiologica Scandinavica - July 24, 2014 Category: Anesthesiology Authors: P. MARHOFER, P.‐A. LÖNNQVIST Tags: Review Article Source Type: research

Prenatal imaging of a fetus with the rare combination of a right congenital diaphragmatic hernia and a giant omphalocele
We present images of a fetus diagnosed with this rare combination of anomalies. Early neonatal death occurred immediately after the full‐term birth due to severe respiratory insufficiency. In this case, disturbance of chest wall development due to the omphalocele rather than the diaphragmatic hernia was considered as the main cause of lung hypoplasia. Our experience suggests that caution should be exercised for severe respiratory insufficiency in a neonate with an omphalocele and diaphragmatic hernia, even in the absence of an intra‐thoracic liver, one of the indicators of poor outcome for congenital diaphragmatic hern...
Source: Congenital Anomalies - July 24, 2014 Category: Genetics & Stem Cells Authors: Ayasa Nonaka, Nobuhiro Hidaka, Saki Kido, Kotaro Fukushima, Kiyoko Kato Tags: Case Report Source Type: research

Increased blood-brain barrier permeability and alterations in perivascular astrocytes and pericytes induced by intracisternal glutaric acid
Conclusions: The present study shows a previously-unknown effect of a perinatal administration of a single intracisternal GA injection on BBB permeability and on key components of the neurovascular unit. The results suggest BBB leakage is a pathogenic mechanism and a potential therapeutic target for patients with GA-I. (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - July 24, 2014 Category: Neurology Authors: Eugenia IsasiLuis BarbeitoSilvia Olivera-Bravo Source Type: research

Placental hematoma mimicking twin anemia polycythemia sequence following selective laser photocoagulation for twin‐twin transfusion syndrome
We describe a case of placental hematoma following selective laser photocoagulation for twin‐twin transfusion syndrome associated with post‐therapy de novo donor twin anemia. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - July 24, 2014 Category: Perinatology & Neonatology Authors: Hen Y. Sela, Russell Miller, Rosanna G. Abellar, Lynn L. Simpson Tags: Research Letter Source Type: research

Controlling childbirth pain tied to lower depression risk
(Northwestern University) Controlling pain during childbirth and post delivery is linked to reduced risk of postpartum depression, says a Northwestern perinatal psychiatrist, based on a new study. The study showed postpartum depression rates doubled for women without pain control. Significant numbers of women have acute and chronic pain related to childbirth and need to consult with their physician if pain continues for several months. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 23, 2014 Category: Global & Universal Source Type: news

Advances in granulocyte test methodologies
Abstract Alloantibodies to human neutrophil antigens (HNA) are involved in clinical conditions such as neonatal alloimmune neutropenia (NAN), autoimmune neutropenia (AIN) and transfusion‐related acute lung injury (TRALI). For the diagnosis of these conditions, the detection of the causative antibody is essential. Presently, the use of a combination of granulocyte agglutination assay (GAT) and granulocyte immunofluorescence test (GIFT) for the screening of granulocyte antibodies, followed by the determination of antibody specificity by the monoclonal antibody‐specific immobilization of granulocyte antigens (MAIGA) is re...
Source: ISBT Science Series - July 23, 2014 Category: Hematology Authors: M. Matsuhashi, N. H. Tsuno, J. Iino, Y. Nagura, H. Okazaki, S. Santoso Tags: State of the Art Source Type: research

Urgent need for better education: example of maternal dyspnea in a twin pregnancy
What's already known about this topic? Monochorionic pregnancies are 1/200 pregnancies, one in seven of whom will develop twin–twin transfusion syndrome (TTTS) TTTS is usually lethal to both twins if untreated. Timely fetoscopic laser ablation of the ‘culprit’ placental anastomoses is curative What does this study add? Surveillance is the chorionicity diagnosis early and q2 weekly ultrasounds until delivery Refer urgently to an appropriate fetal medicine unit if discordant fluid volumes or Dopplers (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - July 23, 2014 Category: Perinatology & Neonatology Authors: David Baud, Tim Van Mieghem, Rory Windrim, Luigi Raio, Johannes Keunen, Greg Ryan Tags: Research Letter Source Type: research

Prenatal management and outcomes in mirror syndrome associated with twin–twin transfusion syndrome
ConclusionTTTS carries a high risk of mirror syndrome, a disease with significant materno‐fetal mortality and morbidity. Amnioreduction alone or with selective feticide in mirror syndrome may transiently aggravate anemia and hemodilution and lead to severe maternal complications. © 2014 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - July 23, 2014 Category: Perinatology & Neonatology Authors: Hanjing Chai, Qun Fang, Xuan Huang, Yi Zhou, Yanmin Luo Tags: Original Article Source Type: research

Busier neonatal units offer better survival rates to premature newborns.
Authors: Abstract Premature newborns are more than one third less likely to die if they are admitted to high volume neonatal units at the hospital of birth rather than low volume units, a UK study suggests. PMID: 25052651 [PubMed - in process] (Source: Nursing Standard)
Source: Nursing Standard - July 23, 2014 Category: Nursing Tags: Nurs Stand Source Type: research

Condyloma acuminata in the tongue and palate of a sexually abused child: a case report
Conclusion: Sexually transmitted disease may occur during sexual abuse. Dentists as well as pediatricians have a role to play in identifying and treating these children. The diagnosis is essentially clinical (anamnesis and physical examination), but also the use of cytology eventually resorts to biopsy of the suspicious lesions for histological examination. The therapeutic option was the excision of the lesions. (Source: BMC Research Notes)
Source: BMC Research Notes - July 23, 2014 Category: Research Authors: Ana PercinotoMarcelle DanelonMarcelo CriveliniRobson CunhaCélio Percinoto Source Type: research

Site-specific predictors of successful recruitment to a perinatal clinical trial.
CONCLUSION: A delay of greater than 3 months in approval of the new Clinical Trial Agreement had an effect which extended into the third year of the trial. Characteristics that were indicative of the presence of a 'system' were the best predictors of recruitment. It may be more effective to limit recruitment sites and focus resources on those sites where investigators are engaged with trial processes and have adequate resources and structures to support them. PMID: 25055812 [PubMed - as supplied by publisher] (Source: Clinical Trials)
Source: Clinical Trials - July 23, 2014 Category: Research Authors: Levett KM, Roberts CL, Simpson JM, Morris JM Tags: Clin Trials Source Type: research

Permanent neonatal diabetes mellitus in China
Conclusions: We suggest that all of the infants with PNDM should undergo genetic evaluation. For infants without KCNJ11 and ABCC8 genetic mutations, oral sulfonylurea should not be considered as treatment. CSII is a useful method for overcoming the difficulties of diabetes, and it may also improve the quality of life of both infants and their parents. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - July 23, 2014 Category: Pediatrics Authors: Ke HuangLi LiangJun-feng FuGuan-pin Dong Source Type: research

Uterine fundal pressure: Is it really a culprit of poor maternal and neonatal outcome?
(Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - July 23, 2014 Category: OBGYN Authors: Shigeki Matsubara Tags: Letter to the Editor Source Type: research

Role of postprandial bile acids in prediction of perinatal outcome in intrahepatic cholestasis of pregnancy
ConclusionPostprandial TBA and difference of fasting and postprandial TBA are associated with asphyxia in ICP. The gestational age at diagnosis and fTBA are associated with adverse perinatal outcomes. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - July 23, 2014 Category: OBGYN Authors: Ayla Sargın Oruç, Berna Seçkin, Nagihan Özcan, Sebnem Özyer, Özlem Uzunlar, Nuri Danışman Tags: Original Article Source Type: research

Obstetric and neonatal outcomes of delayed interval delivery in cerclage and non‐cerclage cases: An analysis of 20 multiple pregnancies
ConclusionCervical cerclage after the first delivery is associated with a longer delivery interval and higher birthweight of retained fetus. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - July 23, 2014 Category: OBGYN Authors: Emek Doger, Yigit Cakiroglu, Yasin Ceylan, Emre Kole, Sebiha Ozkan, Eray Caliskan Tags: Original Article Source Type: research

Role of miR-34c in ketamine-induced neurotoxicity in neonatal mice hippocampus.
Abstract Ketamine is a commonly used pediatric anesthetic, but it might affect development, or even induce neurotoxicity in the neonatal brain. We have used an in vivo neonatal mouse model to induce ketamine-related neurotoxicity in the hippocampus, and found that miR-34c, a microRNA associated with pathogenesis of Alzheimer's disease, was significantly upregulated during ketamine-induced hippocampal neurodegeneration. Functional assay of silencing miR-34c demonstrated that downregulation of miR-34c activated PKC-ERK pathway, upregulated anti-apoptotic protein BCL2, and ameliorated ketamine-induced apoptosis in the...
Source: Cell Biology International - July 23, 2014 Category: Cytology Authors: Zhang Y, Tian J, Chen S, Zhang X, Cao SE Tags: Cell Biol Int Source Type: research

Pigment Epithelium-derived Factor Mediates Impaired Lung Vascular Development in Neonatal Hyperoxia.
Abstract BPD is a chronic lung disease of preterm infants characterized by arrested microvascularization and alveolarization. Studies show the importance of pro-angiogenic factors for alveolarization, but the importance of anti-angiogenic factors is unknown. We proposed that hyperoxia increases the potent angiostatin Pigment Epithelium-derived Factor (PEDF) in neonatal lungs, inhibiting alveolarization and microvascularization. Wild type (WT) and PEDF (-/-) mice were exposed to room air (RA) or 0.9 FiO2 from postnatal day 5 to 13. PEDF protein was increased in hyperoxia compared to RA-exposed lungs (P<0.05). In ...
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Chetty A, Bennett M, Dang L, Nakamura D, Cao GJ, Mujahid S, Volpe M, Herman I, Becerra SP, Nielsen HC Tags: Am J Respir Cell Mol Biol Source Type: research

Role of miR-150 and Glycoprotein Non-metastatic Melanoma Protein B in Angiogenesis During Hyperoxia-induced Neonatal Lung Injury.
Conclusions. GPNMB plays an important role in angiogenesis during hyperoxia-injury. Treatment with GPNMB may offer a novel therapeutic approach in reducing pathologic complications in bronchopulmonary dysplasia. PMID: 25054912 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Narasaraju T, Shukla D, More S, Huang C, Zhang L, Xiao X, Liu L Tags: Am J Respir Cell Mol Biol Source Type: research

Growth factors have a protective effect on neomycin-induced hair cell loss.
Abstract We have demonstrated that selected growth factors (GFs) are involved in regulating survival and proliferation of progenitor cells derived from the neonatal rat organ of Corti (OC). The protective and regenerative effects of these defined growth factors (GFs) on the injured organ of Corti were therefore investigated. The organ of Corti dissected from the Wistar rat pups (P3- P5) was split into apical, middle, and basal parts, explanted and cultured with or without neomycin and growth factors. Insulin-like growth factor-1 (IGF-1), fibroblast growth factor-2 (FGF-2), and epidermal growth factor (EGF) protecte...
Source: Cell Biology International - July 23, 2014 Category: Cytology Authors: Lou X, Yuan H, Xie J, Wang X, Yang L, Zhang Y Tags: Cell Biol Int Source Type: research

Childhood Social Disadvantage, Cardiometabolic Risk, and Chronic Disease in Adulthood
Adverse social environments in early life are hypothesized to become biologically embedded during the first few years of life, with potentially far-reaching implications for health across the life course. Using prospective data from a subset of a US birth cohort, the Collaborative Perinatal Project, started in 1959–1966 (n = 566), we examined associations of social disadvantage assessed in childhood with cardiometabolic function and chronic disease status more than 40 years later (in 2005–2007). Social disadvantage was measured with an index that combined information on adverse socioeconomic and family stabilit...
Source: American Journal of Epidemiology - July 23, 2014 Category: Epidemiology Authors: Non, A. L., Rewak, M., Kawachi, I., Gilman, S. E., Loucks, E. B., Appleton, A. A., Roman, J. C., Buka, S. L., Kubzansky, L. D. Tags: RESEARCH-ARTICLE Source Type: research

[Review] Infection-induced inflammation and cerebral injury in preterm infants
Preterm birth and infectious diseases are the most common causes of neonatal and early childhood deaths worldwide. The rates of preterm birth have increased over recent decades and account for 11% of all births worldwide. Preterm infants are at significant risk of severe infection in early life and throughout childhood. Bacteraemia, inflammation, or both during the neonatal period in preterm infants is associated with adverse outcomes, including death, chronic lung disease, and neurodevelopmental impairment. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - July 22, 2014 Category: Infectious Diseases Authors: Tobias Strunk, Terrie Inder, Xiaoyang Wang, David Burgner, Carina Mallard, Ofer Levy Tags: Review Source Type: research