Trends in the postfortification prevalence of spina bifida and anencephaly in the united states
discuss this article
CONCLUSIONS: While the prevalences of spina bifida and anencephaly in the United States have declined since folic acid fortification in the food supply began, these data suggest that reductions in the prevalence of anencephaly continued during 2001-2004 and that racial and ethnic and other disparities remain. Birth Defects Research (Part A), 2008. © 2008 Wiley-Liss, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - May 16, 2008 Category: Perinatology & Neonatology Authors: Sheree L. Boulet, Quanhe Yang, Cara Mai, Russell S. Kirby, Julianne S. Collins, James M. Robbins, Robert Meyer, Mark A. Canfield, Joe Mulinare, for the National Birth Defects Prevention Network Source Type: journals
Maternal periconceptional smoking and alcohol consumption and risk for select congenital anomalies
discuss this article
CONCLUSIONS: This study observed that maternal alcohol intake increased the risk for d-transposition of the great arteries, NTDs, and multiple CLP in infants. By contrast, smoking was associated with a lower risk of NTDs and conotruncal heart defects. Birth Defects Research (Part A), 2008. © 2008 Wiley-Liss, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - May 15, 2008 Category: Perinatology & Neonatology Authors: Jagteshwar Grewal, Suzan L. Carmichael, Chen Ma, Edward J. Lammer, Gary M. Shaw Source Type: journals
Depressive symptoms during pregnancy in relation to fish consumption and intake of n-3 polyunsaturated fatty acids
discuss this article
Paediatric and Perinatal Epidemiology, Volume 0, Issue 0, Page ???, OnlineEarly Articles.
Summary Sontrop J, Avison WR, Evers SE, Speechley KN, Campbell MK. Depressive symptoms during pregnancy in relation to fish consumption and intake of n-3 polyunsaturated fatty acids. Paediatric and Perinatal Epidemiology 2008. An inverse association ... (Source: Paediatric and Perinatal Epidemiology)
Source: Paediatric and Perinatal Epidemiology - May 8, 2008 Category: Perinatology & Neonatology Tags: article Source Type: journals
Preface.
discuss this article
PMID: 18456069 [PubMed - in process] (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Jain L, Wapner R Tags: Clin Perinatol Source Type: journals
Cesarean birth in the united states: epidemiology, trends, and outcomes.
discuss this article
Cesarean birth in the United States: epidemiology, trends, and outcomes.
Clin Perinatol. 2008 Jun;35(2):293-307
Authors: Macdorman MF, Menacker F, Declercq E
The percentage of United States cesarean births increased from 20.7% in 1996 to 31.1% in 2006. Cesarean rates increased for women of all ages, race/ethnic groups, and gestational ages and in all states. Both primary and repeat cesareans have increased. Increases in primary cesareans in cases of "no indicated risk" have been more rapid than in the overall population and seem the result of changes in obstetric practice rather than changes in the medical risk...
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Macdorman MF, Menacker F, Declercq E Tags: Clin Perinatol Source Type: journals
The relationship between cesarean delivery and gestational age among us singleton births.
discuss this article
The Relationship Between Cesarean Delivery and Gestational Age Among US Singleton Births.
Clin Perinatol. 2008 Jun;35(2):309-23
Authors: Bettegowda VR, Dias T, Davidoff MJ, Damus K, Callaghan WM, Petrini JR
The increasing trend of delivering at earlier gestational ages has raised concerns of the impact on maternal and infant health. The delicate balance of the risks and benefits associated with continuing a pregnancy versus delivering early remains challenging. Among singleton live births in the United States, the proportion of preterm births increased from 9.7% to 10.7% between 1996 and 2004. The increase in s...
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Bettegowda VR, Dias T, Davidoff MJ, Damus K, Callaghan WM, Petrini JR Tags: Clin Perinatol Source Type: journals
Late preterm infants, early term infants, and timing of elective deliveries.
discuss this article
Delivery of infants who are physiologically mature and capable of successful transition to the extrauterine environment is an important priority for obstetric practitioner. A corollary of this goal is to avoid iatrogenic complications of prematurity and maternal complications from delivery. The purpose of this review is to describe the consequences of birth before physiologic maturity in late preterm and term infants, to identify factors contributing to the decline in gestational age of deliveries in the United States, and to describe strategies to reduce premature delivery of late preterm and early term infants.
P...
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Engle WA, Kominiarek MA Tags: Clin Perinatol Source Type: journals
The influence of obstetric practices on late prematurity.
discuss this article
In this article, the authors review the standard management of several maternal and fetal complications of pregnancy and examine the effect these practices may have on the late preterm birth rate. Given the increasing rate of late preterm birth and the increased recognition of the morbidity and mortality associated with delivery between 34 and 37 weeks, standard obstetric practices and practice patterns leading to late preterm birth should be critically evaluated. The possibility of expectant management of some pregnancy complications in the late preterm period should be investigated. Furthermore, prospective research ...
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Fuchs K, Gyamfi C Tags: Clin Perinatol Source Type: journals
Neonatal morbidity and mortality after elective cesarean delivery.
discuss this article
This article explores the effects of elective cesarean delivery (ECD) at term on neonatal morbidity and mortality. Available data have limitations, and do not provide conclusive evidence regarding the safety of planned ECD versus planned vaginal delivery. Some data suggest an association between ECD and increased neonatal respiratory morbidity and lacerations, and possibly decreased central and peripheral nervous system injury. Potentially increased risks of neonatal mortality with ECD at term may be counterbalanced by risks for fetal demise in ongoing pregnancies. Patients and physicians considering ECD should review comp...
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Signore C, Klebanoff M Tags: Clin Perinatol Source Type: journals
Elective cesarean section: its impact on neonatal respiratory outcome.
discuss this article
This article discusses the respiratory morbidity associated with elective cesarean section, the physiologic mechanisms underlying fetal lung fluid absorption, and potential strategies for facilitating neonatal transition when infants are delivered by elective cesarean section before the onset of spontaneous labor.
PMID: 18456075 [PubMed - in process] (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Ramachandrappa A, Jain L Tags: Clin Perinatol Source Type: journals
Cesarean delivery and its impact on the anomalous infant.
discuss this article
Although cesarean deliveries frequently are performed for anomalous fetal conditions, available data do not always support a fetal benefit from this delivery management. The literature on cesarean delivery for anomalous infants reports insufficient information on comorbid neonatal conditions, so these complications are unknown in this population of newborns. In a minority of cases, a cesarean delivery is reasonable to prevent dystocia or optimize outcome. Areas for future investigation include prospective, randomized, controlled trials of prelabor cesarean compared with vaginal deliveries for myelomeningocele and anter...
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Hamrick SE Tags: Clin Perinatol Source Type: journals
The impact of cesarean delivery on transmission of infectious agents to the neonate.
discuss this article
This article outlines those infections known to be transmitted perinatally through the infected birth canal and details the current recommendations for cesarean delivery. Pregnant women with active genital herpes lesions or with known herpes simplex virus infection and a prodromal illness consistent with recurrence at the time of presentation in labor should undergo cesarean delivery. Pregnant women who are HIV infected and have detectable viremia (>1000 copies/mL) should be counseled regarding the potential benefits of cesarean delivery as an adjunct to antiretroviral therapy. Hepatitis C virus (HCV) can be transmitted...
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Sharma D, Spearman P Tags: Clin Perinatol Source Type: journals
Cesarean section and the outcome of very preterm and very low-birthweight infants.
discuss this article
Births of extremely preterm infants, less than 26 weeks' gestation, by cesarean section have increased significantly in the United States over the past decade. The justification for this increase is not well supported in the literature. This review examines recent analyses that suggest there may be some survival advantage for infants less than 26 weeks delivered by cesarean section. The appropriateness of intervening with cesarean sections for these very immature infants, however, remains uncertain.
PMID: 18456078 [PubMed - in process] (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Malloy MH, Doshi S Tags: Clin Perinatol Source Type: journals
Long-term neurologic outcome of infants born by cesarean section.
discuss this article
Prevention of neurologic injury to the fetus through skilled and attentive care during the peripartum period is designed to identify signs of fetal distress so that appropriate obstetric interventions can occur. The impact of mode of delivery on neurologic outcome varies depending on the clinical indication for cesarean delivery and the associated maternal and fetal conditions. This review summarizes current knowledge of the impact of mode of delivery on long-term neurologic outcome.
PMID: 18456079 [PubMed - in process] (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Adams-Chapman I Tags: Clin Perinatol Source Type: journals
The ethical debate of maternal choice and autonomy in cesarean delivery.
discuss this article
This article reviews the current ethical debate of maternal choice and autonomy in elective cesarean delivery.
PMID: 18456080 [PubMed - in process] (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - May 6, 2008 Category: Perinatology & Neonatology Authors: Williams HO Tags: Clin Perinatol Source Type: journals
Analysis of five single nucleotide polymorphisms in the esr1 gene in cryptorchidism
discuss this article
Recent findings suggest that a specific haplotype, including five single nucleotide polymorphisms (SNPs) in the 3[prime]-terminal region of the estrogen receptor [alpha] gene (ESR1), is associated with the risk for cryptorchidism, but results have been conflicting in different populations. The goal of this study was to further define the association between this specific ESR1 haplotype and the risk for nonsyndromic cryptorchidism in a multiracial American population including Caucasian, African American, and Asian American subjects.Applied Biosystems TaqMan SNP Genotyping Assays were used to identify the genotypes of the f...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - May 2, 2008 Category: Perinatology & Neonatology Authors: Yanping Wang, Julia Barthold, Ernesto Figueroa, Ricardo González, Paul H. Noh, Miao Wang, Jeanne Manson Source Type: journals
Maternal urinary tract infections and selected cardiovascular malformations
discuss this article
CONCLUSIONS: In the National Birth Defects Prevention Study there was little evidence to support an association between CVMs and UTIs during the first trimester of pregnancy. Associations between left ventricular outflow tract obstructive defects and maternal UTI as well as between atrioventricular septal defects and maternal UTI were found. Our findings, while not conclusive, suggest that the possible association between maternal UTI and CVMs should be investigated further. Birth Defects Research (Part A), 2008. © 2008 Wiley-Liss, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - May 1, 2008 Category: Perinatology & Neonatology Authors: Mario A. Cleves, Sadia Malik, Shengping Yang, Tonia C. Carter, Charlotte A. Hobbs Source Type: journals
Refinement of 2q and 7p loci in a large multiplex ntd family
discuss this article
CONCLUSIONS: This large NTD family has identified two genomic regions that may harbor NTD susceptibility genes. Ascertainment of another branch of family 8776 and additional fine mapping permitted a 9.1 Mb reduction of the NTD candidate interval on chromosome 7 and 37.3 Mb on chromosome 2 from previously published data. Identification of one or more NTD susceptibility genes in this family could provide insight into genes that may affect other NTD families. Birth Defects Research (Part A), 2008. © 2008 Wiley-Liss, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - May 1, 2008 Category: Perinatology & Neonatology Authors: Demetra S. Stamm, Deborah G. Siegel, Lorraine Mehltretter, Jessica J. Connelly, Alison Trott, Nathen Ellis, Victoria Zismann, Dietrich A. Stephan, Timothy M. George, Michel Vekemans, Allison Ashley-Koch, John R. Gilbert, Simon G. Gregory, Marcy C. Speer, Source Type: journals
Two mthfr polymorphisms, maternal b-vitamin intake, and chds
discuss this article
CONCLUSIONS: The MTHFR C677T and A1298C polymorphisms are not strong risk factors for CHDs. Birth Defects Research (Part A), 2008. © 2008 Wiley-Liss, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - May 1, 2008 Category: Perinatology & Neonatology Authors: Lydi M.J.W. van Driel, Anna C. Verkleij-Hagoort, Robert de Jonge, André G. Uitterlinden, Eric A.P. Steegers, Cornelia M. van Duijn, Régine P.M. Steegers-Theunissen Source Type: journals
Within prisons, is there an association between the quantity of prenatal care and infant birthweight?
discuss this article
Paediatric and Perinatal Epidemiology, Volume 0, Issue 0, Page ???, OnlineEarly Articles.
Summary Howard DL, Strobino D, Sherman S, Crum R. Within prisons, is there an association between the quantity of prenatal care and infant birthweight? Paediatric and Perinatal Epidemiology 2008. There is still controversy surrounding the effectiveness ... (Source: Paediatric and Perinatal Epidemiology)
Source: Paediatric and Perinatal Epidemiology - April 29, 2008 Category: Perinatology & Neonatology Tags: article Source Type: journals
The impact of past pregnancy experience on subsequent perinatal outcomes
discuss this article
Paediatric and Perinatal Epidemiology, Volume 0, Issue 0, Page ???, OnlineEarly Articles.
Summary Hutcheon JA, Platt RW. The impact of past pregnancy experience on subsequent perinatal outcomes. Paediatric and Perinatal Epidemiology 2008. In perinatal epidemiology, the basic unit of analysis has traditionally been the individual pregnancy. In ... (Source: Paediatric and Perinatal Epidemiology)
Source: Paediatric and Perinatal Epidemiology - April 29, 2008 Category: Perinatology & Neonatology Tags: article Source Type: journals
Degree of rural isolation and birth outcomes
discuss this article
Paediatric and Perinatal Epidemiology, Volume 0, Issue 0, Page ???, OnlineEarly Articles.
Summary Luo Z-C, Wilkins R. Degree of rural isolation and birth outcomes. Paediatric and Perinatal Epidemiology 2008. Little is known about how birth outcomes vary in rural areas by degree of rural isolation. We conducted a retrospective cohort study of ... (Source: Paediatric and Perinatal Epidemiology)
Source: Paediatric and Perinatal Epidemiology - April 29, 2008 Category: Perinatology & Neonatology Tags: article Source Type: journals
A long-term monitoring of fetal movement at home using a newly developed sensor: an introduction of maternal micro-arousals evoked by fetal movement during maternal sleep.
discuss this article
CONCLUSIONS: There was a high agreement between subjective maternal markers and fetal movement. Our recording system using the new sensor can be used for home monitoring of fetal movement.
PMID: 18450390 [PubMed - as supplied by publisher] (Source: Early Human Development)
Source: Early Human Development - April 29, 2008 Category: Perinatology & Neonatology Authors: Nishihara K, Horiuchi S, Eto H, Honda M Tags: Early Hum Dev Source Type: journals
Maternal blood pressure in pregnancy and stillbirth: a case-control study of third-trimester stillbirth
discuss this article
This study aimed to investigate if there is an increased risk of fetal loss associated with hypotension during pregnancy. A matched case-control study of stillbirth and maternal blood pressure was conducted in which maternal blood pressures for a total of 124 pregnancies culminating in stillbirth were compared with maternal blood pressures in 243 (matched) pregnancies resulting in a liveborn infant. Women whose diastolic blood pressures fell in a borderline range (60 to 70 mm Hg) were consistently at greater risk of stillbirth relative to normotensive pregnancies. Women who had three or more mean arterial pressure values &...
Source: American Journal of Perinatology - April 28, 2008 Category: Perinatology & Neonatology Source Type: journals
General movements in infants born from mothers with early-onset hypertensive disorders of pregnancy in relation to one year's neurodevelopmental outcome.
discuss this article
CONCLUSIONS: In this prospective study, including small for gestational age, preterm infants about half of them did not have normal GMs at term and three months. There was no association of GMs at term nor three months with neurological outcome at one year, but there was a significant association of GMs at three months with one year psychomotor development.
PMID: 18448276 [PubMed - as supplied by publisher] (Source: Early Human Development)
Source: Early Human Development - April 28, 2008 Category: Perinatology & Neonatology Authors: van Schie PE, Rep A, Ganzevoort W, de Groot L, Wolf H, van Wassenaer AG, de Vries JI, Tags: Early Hum Dev Source Type: journals
Morbid adherent placenta: prediction, diagnosis and management
discuss this article
Research ArticlesJM PALACIOS JARAQUEMADA, CH BRUNO, WA CLAVELLI, Fetal and Maternal Medicine Review, Volume 18 Issue 04 , pp 357-381Abstract (Source: Fetal and Maternal Medicine Review)
Source: Fetal and Maternal Medicine Review - April 27, 2008 Category: Perinatology & Neonatology Source Type: journals
Myometrial activation – coordination, connectivity and contractility
discuss this article
Research ArticlesDAVID A MACINTYRE, ENG-CHENG CHAN, ROGER SMITH, Fetal and Maternal Medicine Review, Volume 18 Issue 04 , pp 333-356Abstract (Source: Fetal and Maternal Medicine Review)
Source: Fetal and Maternal Medicine Review - April 27, 2008 Category: Perinatology & Neonatology Source Type: journals
Mechanical heart valves and pregnancy
discuss this article
Research ArticlesCYNTHIA MAXWELL, MATHEW SERMER, Fetal and Maternal Medicine Review, Volume 18 Issue 04 , pp 311-331Abstract (Source: Fetal and Maternal Medicine Review)
Source: Fetal and Maternal Medicine Review - April 27, 2008 Category: Perinatology & Neonatology Source Type: journals
The ethics of fetocide
discuss this article
Research ArticlesFRANK A CHERVENAK, LAURENCE B McCULLOUGH, Fetal and Maternal Medicine Review, Volume 18 Issue 04 , pp 289-309Abstract (Source: Fetal and Maternal Medicine Review)
Source: Fetal and Maternal Medicine Review - April 27, 2008 Category: Perinatology & Neonatology Source Type: journals
Blood glucose determinations in large for gestational age infants
discuss this article
Amer J PerinatolDOI: 10.1055/s-2008-1076602ABSTRACTOur purpose was to identify factors that may contribute to hypoglycemia in large for gestational age (LGA) infants and subsets of infants for whom blood glucose screening would be clinically helpful. LGA infants of 36 to 42 weeks of gestational age using the Denver criteria were identified from the 1999 through 2001 birth log at Marquette General Hospital, Marquette, Michigan, a rural referral hospital, for a retrospective chart review. Infants of mothers with diabetes were excluded. The impact of maternal factors, intrauterine factors, and birthweight on blood glucose lev...
Source: American Journal of Perinatology - April 25, 2008 Category: Perinatology & Neonatology Source Type: journals
Diagnosing intestinal perforation: a new approach
discuss this article
We present a case of a 25-week growth-restricted neonate at 12 days of life who was diagnosed with occult SIP by a novel mechanism.[...]© Thieme Medical PublishersGet connected:Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - April 25, 2008 Category: Perinatology & Neonatology Source Type: journals
Hemangiomatosis in two sets of premature twins
discuss this article
Amer J PerinatolDOI: 10.1055/s-2008-1076604ABSTRACTWe attempted to identify the association of multifocal hemangiomas, specifically hepatic hemangiomatosis, in twins. We retrospectively reviewed our database of infants with hemangiomas, identifying those twins who both had hemangiomas, and we report two cases of twins with hemangiomatosis, including hepatic hemangiomas. Of 39 sets of twins in our Hemangioma Program, both twins had hemangiomas in seven twin sets. Of these seven sets, only the two reported in this article had hemangiomatosis. There were also five sets of triplets, with one set having two siblings affected by...
Source: American Journal of Perinatology - April 25, 2008 Category: Perinatology & Neonatology Source Type: journals
Stillbirth at term in women of advanced maternal age in the united states: when could the antenatal testing be initiated?
discuss this article
Amer J PerinatolDOI: 10.1055/s-2008-1076605ABSTRACTWe sought to determine if advanced maternal age (AMA) is a risk factor for intrauterine fetal demise (IUFD). We used a U.S. Centers for Disease Control and Prevention database and analyzed outcomes in women 15 to 44 years of age with term singleton gestations. Cox proportional hazards models and Cochran-Mantel-Haenszel tests were used. Results were controlled for maternal race and smoking. After excluding congenital anomalies and medical complications, 6,239,399 singleton term deliveries were identified. When compared with women 25 to 29 years of age, the risk of IUFD incr...
Source: American Journal of Perinatology - April 25, 2008 Category: Perinatology & Neonatology Source Type: journals
Enrichment of collagen plugs with platelets and amniotic fluid cells increases cell proliferation in sealed iatrogenic membrane defects in the foetal rabbit model
discuss this article
The purpose of this study was to evaluate cell proliferation in platelet-enriched collagen plugs with and without addition of amniotic fluid-derived heterologous foetal cells to seal an iatrogenic membrane defect in the foetal rabbit model.Amniotic fluid cells were harvested from three donor does at 23 days of gestation (term = 32 days) and labelled with carboxyfluorescein diacetate succinimidyl ester (CFDA-SE). In 42 other does, foetal membrane defects were induced by foetoscopic needle puncture at 23 days of gestation, and closed with either a platelet-enriched collagen plug with (n = 44) or without (n = 32) amniotic flu...
Source: Prenatal Diagnosis - April 25, 2008 Category: Perinatology & Neonatology Authors: Daisy Liekens, Liesbeth Lewi, Jacques Jani, Liesbeth Heyns, Eline Poliard, Godelieve Verbist, Nicole Ochsenbein-Kölble, Marc Hoylaerts, Jan Deprest Source Type: journals
Biomarkers for detection of prenatal alcohol exposure: a critical review of fatty acid ethyl esters in meconium
discuss this article
CONCLUSIONS: The accurate identification of alcohol-exposed pregnancies represents a significant challenge in the development of FAEE detection cutoffs to maximize the sensitivity and specificity of the test. We present several options for the improvement of exposure assessment in future studies of FAEE as biomarkers for PAE. Birth Defects Research (Part A), 2008. © 2008 Wiley-Liss, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - April 25, 2008 Category: Perinatology & Neonatology Authors: Larry Burd, Ryan Hofer Source Type: journals
Metabolic assessment of the brain using proton magnetic resonance spectroscopy in a growth-restricted human fetus: case report
discuss this article
Amer J PerinatolDOI: 10.1055/s-2008-1076603ABSTRACTProton magnetic resonance spectroscopy (MRS) is a noninvasive method to assess concentrations of different metabolites in tissues, including the brain. We evaluated a fetus with growth restriction using Doppler ultrasound and proton MRS. Doppler assessment revealed absent end diastolic flow in the umbilical artery. Diastolic flow was increased in the middle cerebral artery. Proton MRS of the fetal brain showed lactate and a low N-acetylaspartate/choline index, metabolic markers of starvation/hypoxia. Proton MRS gave us in vivo metabolic information of the brain of a fetus ...
Source: American Journal of Perinatology - April 24, 2008 Category: Perinatology & Neonatology Source Type: journals
Serum leptin in first-trimester down syndrome pregnancies
discuss this article
We examined whether leptin is a maternal serum marker for foetal DS in the first trimester.Serum samples from 44 pregnant women with a DS foetus, and 135 control pregnant women in week 8 to 14 had the leptin concentration determined by immunoassay and the concentrations were converted into multiples of the median (MoM) of controls based on log-regression analysis. The distributions of log10 MoM leptin was compared in DS and control pregnancies.Serum leptin increased significantly with gestational age in controls (p = 0.02). The mean log10 MoM in controls was - 0.0486, with a median empirical MoM of 0.89, and - 0.0618, with...
Source: Prenatal Diagnosis - April 24, 2008 Category: Perinatology & Neonatology Authors: Paula Hedley, Michael Christiansen Source Type: journals
Clinical, sonographic, and epidemiologic features of second- and early third-trimester spontaneous antepartum uterine rupture: a cohort study
discuss this article
To present prenatal findings and maternal and neonatal outcomes following second- and early third-trimester spontaneous antepartum uterine rupture events in our institute.Charts of patients with full-thickness second- or early third-trimester symptomatic uterine ruptures locally treated between 1984 and 2007 were evaluated.There were seven events involving six women, all requiring emergency laparotomy, and cesarean section (CS). During the study period in our institute, there were 120 636 singleton deliveries ([ge]22 weeks' gestation), including 5 of our cases, while in 2 cases, the rupture occurred earlier ( (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - April 24, 2008 Category: Perinatology & Neonatology Authors: Zvi Vaknin, Ron Maymon, Sonia Mendlovic, Oshri Barel, Arie Herman, Dan Sherman Source Type: journals
Trisomy 18 presenting with severe limb deformations
discuss this article
No Abstract. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - April 24, 2008 Category: Perinatology & Neonatology Authors: Ingrid Witters, Jean-Pierre Fryns Source Type: journals
Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects
discuss this article
To investigate the associations between biomarkers and genetic variants involved in homocysteine metabolism and the risk of complex birth defects.Total homocysteine (tHcy), folate, cobalamin, apo-transcobalamin (apo-TC) and apo-haptocorrin (apo-HC) were measured in the amniotic fluid of 82 women who were pregnant with a child having a complex birth defect, such as neural tube defect, cleft lip and/or palate, heart defect or omphalocele, and in 110 women pregnant with a non-malformed child. The determined genotypes of the child comprised of 5, 10-methylenetetrahydrofolate reductase (MTHFR 677C > T, 1298A > C), methionine sy...
Source: Prenatal Diagnosis - April 24, 2008 Category: Perinatology & Neonatology Authors: R. Brouns, N. Ursem, J. Lindemans, W. Hop, S. Pluijm, E. Steegers, R. Steegers-Theunissen Source Type: journals
Book review
discuss this article
No abstract. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - April 24, 2008 Category: Perinatology & Neonatology Authors: Robert L. Brent Source Type: journals
Oxidative stress during diabetic pregnancy disrupts cardiac neural crest migration and causes outflow tract defects
discuss this article
CONCLUSIONS: In diabetic pregnancy, oxidative stress, which inhibits expression of genes required for CNC viability, causes subsequent CNC depletion by apoptosis during migration, which leads to outflow tract defects. Birth Defects Research (Part A), 2008. © 2008 Wiley-Liss, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - April 24, 2008 Category: Perinatology & Neonatology Authors: Sarah C. Morgan, Frédéric Relaix, Lisa L. Sandell, Mary R. Loeken Source Type: journals
Placental expression of insulin-like growth factor-i, fibroblast growth factor-basic and neural cell adhesion molecule in pregnancies with small for gestational age fetuses
discuss this article
Placental expression of insulin-like growth factor-I, fibroblast growth factor-basic and neural cell adhesion molecule in pregnancies with small for gestational age fetuses
Journal of Perinatology advance online publication, April 24, 2008. doi:10.1038/jp.2008.27
Authors: S Özkan, B Vural, C Dalçık, A Taş
& H Dalçık (Source: Journal of Perinatology)
Source: Journal of Perinatology - April 24, 2008 Category: Perinatology & Neonatology Authors: S ÖzkanB VuralC DalçıkA TaşH Dalçık Source Type: journals
Comments on inositol supplementation in pregnancies at risk of apparently folate-resistant ntds
discuss this article
No abstract. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - April 22, 2008 Category: Perinatology & Neonatology Authors: Gary Shaw Source Type: journals
[postscript] meta-variability of advice on drugs in the breastfeeding mother: the example of {beta}-blockers
discuss this article
(Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 21, 2008 Category: Perinatology & Neonatology Authors: Davanzo, R, Rubert, L, Oretti, C Tags: PostScript Source Type: journals
[postscript] group b streptococcus and preventive strategies in europe
discuss this article
(Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 21, 2008 Category: Perinatology & Neonatology Authors: Berardi, A, Lugli, L, Rossi, C, Morini, M S, Vagnarelli, F, Ferrari, F Tags: PostScript Source Type: journals
[perinatal lessons from the past] dr leonard colebrook, frs (1883-1967) and the chemotherapeutic conquest of puerperal infection
discuss this article
(Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 21, 2008 Category: Perinatology & Neonatology Authors: Dunn, P M Tags: Perinatal lessons from the past Source Type: journals
[images in neonatal medicine] kneeling delivery in america 2000 years ago
discuss this article
(Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 21, 2008 Category: Perinatology & Neonatology Authors: Bernal, J E, Briceno, I Tags: Images in neonatal medicine Source Type: journals
[reviews] difficult extubation in low birthweight infants
discuss this article
Randomised trials have demonstrated that ventilation techniques which support every spontaneous breath are the most efficacious weaning modes. Nasal continuous positive airway pressure after extubation reduces the likelihood of incidents leading to the need for reintubation in very low birthweight infants; further work is needed to determine if there are advantages of particular delivery techniques. Both methylxanthines and dexamethasone facilitate weaning and extubation; the efficacy of low-dose dexamethasone merits further investigation. Assessments of the efficacy of respiratory efforts and hence the balance of respirat...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 21, 2008 Category: Perinatology & Neonatology Authors: Greenough, A, Prendergast, M Tags: Reviews Source Type: journals
[case reports] transient neonatal diabetes mellitus in extremely preterm infant
discuss this article
A report of transient neonatal diabetes mellitus in an extremely preterm infant (gestational age 27 weeks, birth weight 718 g). The patient had intrauterine growth retardation and developed hyperglycaemia on the first day of life. Insulin administration was discontinued on the 89th day of life, which was 1 day before the original due date. This case suggests that (a) insufficient insulin secretion started at least from the second trimester of the pregnancy; (b) the duration needed for recovery of insulin secretion was not dependent on the maturity. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 21, 2008 Category: Perinatology & Neonatology Authors: Nishimaki, S, Yukawa, T, Makita, Y, Honda, H, Kikuchi, N, Minamisawa, S, Yokota, S Tags: Case reports Source Type: journals
