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Perinatology & Neonatology

This page shows you the most recent publications within this specialty of the MedWorm directory.

Implementing safe sleep practices in a neonatal intensive care unit - Voos KC, Terreros A, Larimore P, Leick-Rude MK, Park N.
OBJECTIVE: SIDS remains the leading cause of death in the postnatal period. Accidental suffocation and strangulation in bed deaths have quadrupled. The American Academy of Pediatrics (AAP) expanded its back to sleep recommendations to include a safe sleep ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - September 20, 2014 Category: Global & Universal Tags: Age: Infants and Children Source Type: news

Imaging Concerns Unique to Twin Pregnancy
The incidence of multiple gestations is increasing with rising maternal age and the utilization of artificial reproductive techniques. Twinning confers an increased risk to the pregnancy, with higher incidence of structural anomalies, preterm delivery, and perinatal morbidity and mortality. Certain conditions are unique to twin pregnancy, such as the twin-to-twin transfusion syndrome and the acardiac twin, secondary to vascular sharing between both the fetuses. Conjoined twinning is a phenomenon occurring because of late splitting of the zygote. Advances in imaging have increased our ability to manage multiple pregnancies ...
Source: Current Problems in Diagnostic Radiology - September 20, 2014 Category: Radiology Authors: Sowmya Mahalingam, Manjiri Dighe Tags: Review Articles Source Type: research

Iodine deficiency in children.
Abstract Iodine is an essential trace mineral, required for the production of thyroid hormone. Iodine deficiency may result in goiter, hypothyroidism, miscarriage, stillbirth, congenital anomalies, infant and neonatal mortality, and impaired growth. Adequate thyroid hormone is critically important for normal growth and neurodevelopment in fetal life, infancy and childhood. The population iodine status is most commonly assessed using median urinary iodine concentration values, but goiter prevalence (determined by palpation or by ultrasound), serum thyroglobulin levels, and neonatal thyroid-stimulating hormone values...
Source: Endocrine Development - September 20, 2014 Category: Endocrinology Authors: Pearce EN Tags: Endocr Dev Source Type: research

Central hypothyroidism in children.
Abstract Central congenital hypothyroidism (CCH) is an underdiagnosed disorder poorly described in childhood and adolescence. Congenital defects in thyroid-stimulating hormone (TSH) synthesis, secretion or bioactivity may lead to a state of 'regulatory' hypothyroidism expressed through aberrantly low or normal TSH levels and low thyroxine (T4), a hormonal pattern undetectable by TSH-based neonatal screening programs for congenital hypothyroidism (CH) implemented in most countries worldwide. CCH is more prevalent than previously thought, reaching 1 in 16,000 neonates in countries consistently identifying CCH through...
Source: Endocrine Development - September 20, 2014 Category: Endocrinology Authors: García M, Fernández A, Moreno JC Tags: Endocr Dev Source Type: research

Neonatal screening for congenital hypothyroidism.
Abstract The possibility of measuring thyroid hormones from blood dried on filter paper opened the way to identifying neonates with congenital hypothyroidism (CH) already in the first days of life. Consequently the early initiation of adequate replacement therapy opened the way to an effective prevention of mental retardation. Timely and complete specimen collection, transport logistics, rapid analysis and communication of results are key points for the organization of a CH newborn screening program. Close collaboration between laboratory and treating specialists is necessary to ensure an adequate treatment and fol...
Source: Endocrine Development - September 20, 2014 Category: Endocrinology Authors: Torresani T Tags: Endocr Dev Source Type: research

[Department of Error] Department of Error
Renfrew MJ, McFadden A, Bastos MH, et al. Midwifery and quality care: findings from a new evidence-informed framework for maternal and newborn care. Lancet 2014; 384: 1129–45—In the table, the outcomes “perinatal, neonatal, or infant mortality reduced” and “fetal loss reduced” should have been placed after “increased contraceptive use”. This change has been made to the online version as of July 11, 2014, and the printed Article is correct. (Source: LANCET)
Source: LANCET - September 20, 2014 Category: Journals (General) Authors: The Lancet Tags: Department of Error Source Type: research

[Series] The projected effect of scaling up midwifery
We used the Lives Saved Tool (LiST) to estimate deaths averted if midwifery was scaled up in 78 countries classified into three tertiles using the Human Development Index (HDI). We selected interventions in LiST to encompass the scope of midwifery practice, including prepregnancy, antenatal, labour, birth, and post-partum care, and family planning. Modest (10%), substantial (25%), or universal (95%) scale-up scenarios from present baseline levels were all found to reduce maternal deaths, stillbirths, and neonatal deaths by 2025 in all countries tested. (Source: LANCET)
Source: LANCET - September 20, 2014 Category: Journals (General) Authors: Caroline S E Homer, Ingrid K Friberg, Marcos Augusto Bastos Dias, Petra ten Hoope-Bender, Jane Sandall, Anna Maria Speciale, Linda A Bartlett Tags: Series Source Type: research

Preventing MRSA in the NICU vs the Adult ICUPreventing MRSA in the NICU vs the Adult ICU
The CDC has recently published protocols for implementing universal decolonization of MRSA in ICUs. Why can’t we use these protocols in the NICU? Journal of Perinatology : Official Journal of the California Perinatal Association (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 19, 2014 Category: Consumer Health News Tags: Pediatrics Journal Article Source Type: news

Demographics, clinical characteristics and neonatal outcomes in a rural Ugandan NICU
Background: Ninety-six percent of the world's 3 million neonatal deaths occur in developing countries where the majority of births occur outside of a facility. Community-based approaches to the identification and management of neonatal illness have reduced neonatal mortality over the last decade. To further expand life-saving services, improvements in access to quality facility-based neonatal care are required. Evaluation of rural neonatal intensive care unit referral centers provides opportunities to further understand determinants of neonatal mortality in developing countries. Our objective was to describe demographics, ...
Source: BMC Pregnancy and Childbirth - Latest articles - September 19, 2014 Category: OBGYN Authors: Anna HedstromTove RymanChristine OtaiJames NyonyintonoRyan McAdamsDeborah LesterManeesh Batra Source Type: research

Probiotics for prevention of necrotizing enterocolitis in preterm infants
Abstract BackgroundNecrotizing enterocolitis (NEC) and nosocomial sepsis are associated with increased morbidity and mortality in preterm infants. Through prevention of bacterial migration across the mucosa, competitive exclusion of pathogenic bacteria, and enhancing the immune responses of the host, prophylactic enteral probiotics (live microbial supplements) may play a role in reducing NEC and the associated morbidity. ObjectivesTo compare the efficacy and safety of prophylactic enteral probiotics administration versus placebo or no treatment in the prevention of severe NEC or sepsis, or both, in preterm infants. Search ...
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 19, 2014 Category: Pediatrics Authors: Khalid AlFaleh, Jasim Anabrees Tags: Intervention Review Source Type: research

Facilitators and barriers to facility-based delivery in low- and middle-income countries: a qualitative evidence synthesis
High-quality obstetric delivery in a health facility reduces maternal and perinatal morbidity and mortality. This systematic review synthesizes qualitative evidence related to the facilitators and barriers to delivering at health facilities in low- and middle-income countries. We aim to provide a useful framework for better understanding how various factors influence the decision-making process and the ultimate location of delivery at a facility or elsewhere. We conducted a qualitative evidence synthesis using a thematic analysis. Searches were conducted in PubMed, CINAHL and gray literature databases. Study quality was ev...
Source: Epidemiologic Perspectives and Innovations - September 19, 2014 Category: Epidemiology Authors: Meghan A BohrenErin C HunterHeather M Munthe-KaasJoão Paulo SouzaJoshua P VogelA Metin Gülmezoglu Source Type: research

Issue Information
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 19, 2014 Category: Perinatology & Neonatology Tags: Issue Information Source Type: research

Population pharmacokinetics and haemodynamic effects of norepinephrine in hypotensive critically ill children
ConclusionThe pharmacokinetics and haemodynamic effects of norepinephrine in hypotensive critically ill children highlight the between‐subject variability which is related to the substantial role of age, BW and severity of illness. Taking into account these individual characteristics may help clinicians in determining an appropriate initial a priori dosing regimen. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - September 19, 2014 Category: Drugs & Pharmacology Authors: Mehdi Oualha, Jean‐Marc Tréluyer, Fabrice Lesage, Laure Saint Blanquat, Laurent Dupic, Philippe Hubert, Odile Spreux‐Varoquaux, Saïk Urien Tags: Paediatric Clinical Pharmacology Source Type: research

Observational, retrospective study of a large cohort of patients with Niemann-Pick disease type C in the Czech Republic: a surprisingly stable diagnostic rate spanning almost 40 years
Conclusions: These data demonstrate the evolution of the diagnostic process in NPC over the last four decades. We estimate the contemporary birth prevalence of NPC in the Czech Republic at 0.93 per 100,000. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - September 19, 2014 Category: Internal Medicine Authors: Helena JahnovaLenka DvorakovaHana VlaskovaHelena HulkovaHelena PoupetovaMartin HrebicekPavel Jesina Source Type: research

[Antibiotic Resistance] Clone wars: Let's pick out the superbugs
Since the 1960s, group B streptococci (GBS) have lost genetic diversity, yet they cause more virulent neonatal infections and show high rates of tetracycline resistance. The puzzle – [Read More] (Source: Editors' Choice)
Source: Editors' Choice - September 18, 2014 Category: Science Authors: Caroline Ash Tags: Antibiotic Resistance Source Type: research

From high risk to low risk, WakeMed says it has services to meet all pregnancies
When the freestanding birthing center in Cary opens in October, it will broaden WakeMed’s bookends on its continuum of pregnancy and baby care. WakeMed Health & Hospitals partnered with Baby+Company to open a freestanding birth center in Cary, which offers new mothers with low-risk pregnancies an alternative to a hospital birth. Read: WakeMed to open freestanding birthing center with Baby+Co Already, WakeMed has an impressive neonatal intensive care unit, which provides developmentally supportive… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 18, 2014 Category: Biotechnology Authors: Jason deBruyn Source Type: research

From high risk to low risk, WakeMed says it has services to meet all pregnancies
When the freestanding birthing center in Cary opens in October, it will broaden WakeMed’s bookends on its continuum of pregnancy and baby care. WakeMed Health & Hospitals partnered with Baby+Company to open a freestanding birth center in Cary, which offers new mothers with low-risk pregnancies an alternative to a hospital birth. Read: WakeMed to open freestanding birthing center with Baby+Co Already, WakeMed has an impressive neonatal intensive care unit, which provides developmentally supportive… (Source: bizjournals.com Health Care:Hospitals headlines)
Source: bizjournals.com Health Care:Hospitals headlines - September 18, 2014 Category: Hospital Management Authors: Jason deBruyn Source Type: research

Comforting Touch Has Benefits in Neonatal Intensive CareComforting Touch Has Benefits in Neonatal Intensive Care
Babies treated to a type of rhythmic touch known as the M Technique experience better growth and improvement on physiologic and behavioral measures. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 18, 2014 Category: Consumer Health News Tags: Nursing News Source Type: news

Mode of delivery in term and preterm twins: a review
Review Articles D. HUI, J. F. R. BARRETT, Fetal and Maternal Medicine Review, Volume 25 Issue 01, pp 1-11Abstract (Source: Fetal and Maternal Medicine Review)
Source: Fetal and Maternal Medicine Review - September 18, 2014 Category: Perinatology & Neonatology Source Type: research

The genetic sonogram
Review Articles ICHCHHA MADAN, MARK REDMAN, RICHARD BRONSTEEN, RAY O BAHADO-SINGH, LUIS F GONCALVES, Fetal and Maternal Medicine Review, Volume 25 Issue 01, pp 12-41Abstract (Source: Fetal and Maternal Medicine Review)
Source: Fetal and Maternal Medicine Review - September 18, 2014 Category: Perinatology & Neonatology Source Type: research

Angiogenic imbalances in the pathogenesis of pregnancy complications
Review Articles JIMMY ESPINOZA, Fetal and Maternal Medicine Review, Volume 25 Issue 01, pp 42-58Abstract (Source: Fetal and Maternal Medicine Review)
Source: Fetal and Maternal Medicine Review - September 18, 2014 Category: Perinatology & Neonatology Source Type: research

The role of spatio-temporal imaging correlation (stic) in the prenatal diagnosis of congenital heart defects
Review Articles JIMMY ESPINOZA, Fetal and Maternal Medicine Review, Volume 25 Issue 01, pp 59-72Abstract (Source: Fetal and Maternal Medicine Review)
Source: Fetal and Maternal Medicine Review - September 18, 2014 Category: Perinatology & Neonatology Source Type: research

Vaginal microbiome–pregnant host interactions determine a significant proportion of preterm labour
Miscellaneous MANJU CHANDIRAMANI, PHILLIP R BENNETT, RICHARD BROWN, YUN S LEE, DAVID A. MACINTYRE, Fetal and Maternal Medicine Review, Volume 25 Issue 01, pp 73-78Abstract (Source: Fetal and Maternal Medicine Review)
Source: Fetal and Maternal Medicine Review - September 18, 2014 Category: Perinatology & Neonatology Source Type: research

The Triple Test Markers Profile Among Fetuses and Children Diagnosed With Umbilical Vein Varix
Umbilical vein varix (UVV) is defined as a focal enlargement of the umbilical vein and represents approximately 4% of fetal umbilical cord malformations. The reported neonatal outcome of fetuses with UVV varies widely due to its rarity, hence the small sample sizes of the case series in the literature. Earlier studies reported high fetal mortality, but more recent reports have demonstrated no association between UVV and intrauterine fetal death. A recent study has described a possible association between UVV diagnosed prenatally and child developmental delay. The present study of fetuses with UVV was done to evaluate and c...
Source: Journal of Diagnostic Medical Sonography - September 18, 2014 Category: Radiology Authors: Melcer, Y., Wiener, Y., Ben-Ami, I., Levinsohn-Tavor, O., Feldman, N., Maymon, R. Tags: Original Articles Source Type: research

Hepatitis B and C in pregnancy: a review and recommendations for care
K K Leslie (Source: Journal of Perinatology)
Source: Journal of Perinatology - September 18, 2014 Category: Perinatology & Neonatology Authors: J C DunkelbergE M F BerkleyK W ThielK K Leslie Source Type: research

Does adopting a prenatal substance use protocol reduce racial disparities in CPS reporting related to maternal drug use? A California case study
Does adopting a prenatal substance use protocol reduce racial disparities in CPS reporting related to maternal drug use? A California case study Journal of Perinatology advance online publication, September 18 2014. doi:10.1038/jp.2014.168 Authors: S C M Roberts, E Zahnd, C Sufrin & M A Armstrong (Source: Journal of Perinatology)
Source: Journal of Perinatology - September 18, 2014 Category: Perinatology & Neonatology Authors: S C M RobertsE ZahndC SufrinM A Armstrong Source Type: research

Ultrasound to diagnose spontaneous intestinal perforation in infants weighing ⩽1000 g at birth
Ultrasound to diagnose spontaneous intestinal perforation in infants weighing ⩽1000 g at birth Journal of Perinatology advance online publication, September 18 2014. doi:10.1038/jp.2014.169 Authors: A Fischer, L Vachon, M Durand & R G Cayabyab (Source: Journal of Perinatology)
Source: Journal of Perinatology - September 18, 2014 Category: Perinatology & Neonatology Authors: A FischerL VachonM DurandR G Cayabyab Source Type: research

Does diagnosis influence end-of-life decisions in the neonatal intensive care unit?
Does diagnosis influence end-of-life decisions in the neonatal intensive care unit? Journal of Perinatology advance online publication, September 18 2014. doi:10.1038/jp.2014.170 Authors: J Weiner, J Sharma, J Lantos & H Kilbride (Source: Journal of Perinatology)
Source: Journal of Perinatology - September 18, 2014 Category: Perinatology & Neonatology Authors: J WeinerJ SharmaJ LantosH Kilbride Source Type: research

Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges
Nature Immunology 15, 895 (2014). doi:10.1038/ni.2961 Authors: Peter Aaby, Tobias R Kollmann & Christine Stabell Benn (Source: Nature Immunology)
Source: Nature Immunology - September 18, 2014 Category: Allergy & Immunology Authors: Peter AabyTobias R KollmannChristine Stabell Benn Tags: Commentary Source Type: research

Relevance of hospital characteristics as performance indicators for treatment of very-low-birth-weight neonates
Conclusion: A selective referral strategy based solely on hospital volume will fall short of the task of optimal allocation of neonatal care by means of centralization. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - September 18, 2014 Category: Journals (General) Authors: Esser, M., Lack, N., Riedel, C., Mansmann, U., von Kries, R. Tags: Health services research Source Type: research

Interventions to enhance informed choices among invitees of screening programmes--a systematic review
Conclusion: The empirical evidence regarding interventions to improve informed decision making in screening is limited. It is unknown which strategies to enhance informed decision making are most effective, although DAs are promising. Systematic development of interventions to enhance informed choices in screening deserves priority, especially in disadvantaged groups. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - September 18, 2014 Category: Journals (General) Authors: van Agt, H. M. E., Korfage, I. J., Essink-Bot, M.-L. Tags: Screening and early detection Source Type: research

Prevalence and determinants of unintended childbirth in Ethiopia
Conclusion: The study found a relatively high prevalence of unintended childbirth in Ethiopia and this implies high levels of unmet need for child spacing and limiting. There is much need for better targeted family planning programs and strategies to strengthen and improve access to contraceptive services, to raise educational levels, and related information and communication particularly for those affected groups including young, unmarried, multipara, and those with less than secondary level of education. Further quantitative and qualitative research on the consequences of unintended pregnancy and childbirth related to pr...
Source: BMC Pregnancy and Childbirth - Latest articles - September 18, 2014 Category: OBGYN Authors: Yibeltal TebekawBezuhan AemroCharles Teller Source Type: research

Ramadan fasting and newborn's birth weight in pregnant Muslim women in The Netherlands.
Abstract Many Muslim women worldwide are pregnant during Ramadan and adhere to Ramadan fasting during pregnancy. In the present study, we determined whether maternal adherence to Ramadan fasting during pregnancy has an impact on the birth weight of the newborn, and whether the effects differed according to trimester in which Ramadan fasting took place. A prospective cohort study was conducted in 130 pregnant Muslim women who attended antenatal care in Amsterdam and Zaanstad, The Netherlands. Data on adherence to Ramadan fasting during pregnancy and demographics were self-reported by pregnant women, and the outcome ...
Source: The British Journal of Nutrition - September 18, 2014 Category: Nutrition Authors: Savitri AI, Yadegari N, Bakker J, van Ewijk RJ, Grobbee DE, Painter RC, Uiterwaal CS, Roseboom TJ Tags: Br J Nutr Source Type: research

Muscle transcriptomic investigation of late fetal development identifies candidate genes for piglet maturity
Conclusion: These results reveal the biological mechanisms that regulate muscle maturity in piglets. Maturity isalso under the conflicting regulation of the parental genomes. Crucial genes, which could explain thebiological differences in maturity observed between LWand MS breeds, were identified. These genescould be excellent candidates for a key role in the maturity. (Source: BioMed Central)
Source: BioMed Central - September 17, 2014 Category: Journals (General) Authors: Valentin VoilletMagali SanCristobalYannick LippiPascal GP MartinNathalie IannuccelliChristine LascorFlorence VignolesYvon BillonLaurianne CanarioLaurence Liaubet Source Type: research

Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood
Conclusions: Our study shows for the first time, in mice, that a peripheral LPS treatment at PND14 differentially alters emotional behaviors, but not spatial memory, at adolescence and adulthood. The behavioral effect of LPS at PND14 could be attributed to HPA axis deregulation and neurogenesis impairment. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 17, 2014 Category: Neurology Authors: Anne-Laure DinelCorinne JoffrePierre TrifilieffAgnes AubertAline FouryPascale Le RuyetSophie Layé Source Type: research

Right‐sided congenital diaphragmatic hernia in a decade of fetal surgery
ConclusionsRight‐sided CDH seems to have a poorer outcome than that reported for fetuses with left‐sided CDH with similar lung size before birth. Survival rates after expectant management with observed/expected lung‐to‐head ratio values ≤45 and ≤30% were 17 and 0%, respectively. In those undergoing fetal surgery (observed/expected lung‐to‐head ratio ≤45%) there was an apparent increase (42%). (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - September 17, 2014 Category: OBGYN Authors: P DeKoninck, O Gomez, I Sandaite, J Richter, K Nawapun, A Eerdekens, JC Ramirez, F Claus, E Gratacos, J Deprest Tags: Original Article Source Type: research

Genetic Diversity Influences the Response of the Brain to Developmental Lead Exposure
In this study, we used gene microarray profiling to identify Pb-responsive genes in rats of different genetic backgrounds, including inbred (Fischer 344 (F344)) and outbred (Long Evans (LE), Sprague Dawley (SD)) strains, to investigate the role that genetic variation may play in influencing outcomes from developmental Pb exposure. Male and female animals received either perinatal (gestation through lactation) or postnatal (birth through weaning) exposure to Pb in food (0, 250, or 750 ppm). RNA was extracted from the hippocampus at day 55 and hybridized to Affymetrix Rat Gene 1.0 ST Arrays. There were significant strain-spe...
Source: Toxicological Sciences - September 17, 2014 Category: Toxicology Authors: Schneider, J. S., Talsania, K., Mettil, W., Anderson, D. W. Tags: Metals Source Type: research

Gestational and Lactational Exposure to Atrazine via the Drinking Water Causes Specific Behavioral Deficits and Selectively Alters Monoaminergic Systems in C57BL/6 Mouse Dams, Juvenile and Adult Offspring
This study aimed to investigate neurobehavioral and neurochemical effects of ATR in C57BL/6 mouse offspring and dams exposed to a relatively low (3 mg/l, estimated intake 1.4 mg/kg/day) concentration of ATR via the drinking water (DW) from gestational day 6 to postnatal day (PND) 23. Behavioral tests included open field, pole, grip strength, novel object recognition (NOR), forced swim, and marble burying tests. Maternal weight gain and offspring (PND21, 35, and 70) body or brain weights were not affected by ATR. However, ATR-treated dams exhibited decreased NOR performance and a trend toward hyperactivity. Juvenile offspri...
Source: Toxicological Sciences - September 17, 2014 Category: Toxicology Authors: Lin, Z., Dodd, C. A., Xiao, S., Krishna, S., Ye, X., Filipov, N. M. Tags: Neurotoxicology Source Type: research

Human Hepatic UGT2B15 Developmental Expression
Human hepatic UGT2B15 developmental expression changes may alter the metabolism of important drugs and toxicants such as bisphenol A (BPA). Previously, UGT2B15 ontogeny knowledge consisted of transcript data, a dubious surrogate for protein expression. Herein, UGT2B15 protein content was determined in human hepatic microsomes (n = 236, 8 weeks gestation to 18 years). The impact of a common, functional single nucleotide polymorphism (g.253G>T), present in UGT2B15*2 and *5 alleles, was also tested. UGT2B15 expression began during late fetal life, at about 18% of mature values (medians = 48, 267 pmoles/mg of microsomal pro...
Source: Toxicological Sciences - September 17, 2014 Category: Toxicology Authors: Divakaran, K., Hines, R. N., McCarver, D. G. Tags: Molecular Biology Source Type: research

A single centre study on birth of children with transfusion‐dependent thalassaemia in Malaysia and reasons for ineffective prevention
ConclusionThe current poor uptake of voluntary thalassaemia screening in Malaysia and inadequate access to counselling and prenatal diagnostic services contributed to ineffective prevention. A considerable number of Malaysian Muslims may accept the termination option if given access to comprehensive genetic counselling services. © 2014 John Wiley & Sons, Ltd. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - September 17, 2014 Category: Perinatology & Neonatology Authors: C. F. Ngim, H. Ibrahim, N. M. Lai, C. S. Ng Tags: Original Article Source Type: research

TGFβ and Wnt in Cardiac Outflow Tract Defects in Offspring of Diabetic Pregnancies
CONCLUSIONSMaternal diabetes generates oxidative and ER stress conditions, suppresses TGFβ and Wnt signaling, inhibits cell proliferation and cellularization of the endocardial cushions, leading to OFT septal defects. Activin‐A plays a role in hyperglycemia‐suppressed proliferation of the endocardial cells (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - September 17, 2014 Category: Perinatology & Neonatology Authors: Zhiyong Zhao Tags: Research Article Source Type: research

Early detection of congenital syphilis
Nagalakshmi Chowdhary, BS Kavya Rani, KS Mukunda, NK KiranJournal of Indian Society of Pedodontics and Preventive Dentistry 2014 32(4):333-337Late congenital syphilis is a very rare clinical entity, and its early diagnosis and treatment is essential. Dental findings often provide valuable evidence for the diagnosis of late congenital syphilis. It occurs due to the transmission of the disease from an infected mother to her fetus through placenta. This long forgotten disease continues to effect pregnant women resulting in perinatal morbidity and mortality. Congenital syphilis is a preventable disease, and its presence reflec...
Source: Journal of Indian Society of Pedodontics and Preventive Dentistry - September 17, 2014 Category: Dentistry Authors: Nagalakshmi ChowdharyBS Kavya RaniKS MukundaNK Kiran Source Type: research

Treatment Response in Association with Adherence Patterns to Highly Active Antiretroviral Therapy in Pediatric Patients with Perinatally Acquired HIV Infection
Conclusion: Alteration of adherence to HAART is a significant predictor of persistent virologic failure and high viremia in perinatally infected HIV patients. Implementation of longitudinal adherence assessments may target patients with nonsustained adherence patterns and help decrease the risk for virologic failure and disease progression. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - September 17, 2014 Category: Infectious Diseases Authors: Malhotra, A., Whitley-Williams, P. N., Gaur, S., Petrova, A. Tags: Antiretroviral Therapy Source Type: research

Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes.
CONCLUSIONS: We hypothesize that high glibenclamide doses in the mother led to transplacental passage of the drug and overstimulation of fetal β-cells, which resulted in severe hyperinsulinemic hypoglycemia in the neonate (who did not carry the mutation) and contributed to fetal macrosomia. We suggest that glibenclamide (and other SUs) should be avoided in mothers with PNDM if the baby does not carry the mutation or if prenatal screening has not been performed, while glibenclamide may be beneficial when the fetus is a PNDM carrier. PMID: 25231897 [PubMed - as supplied by publisher] (Source: Diabetes Care)
Source: Diabetes Care - September 17, 2014 Category: Endocrinology Authors: Myngheer N, Allegaert K, Hattersley A, McDonald T, Kramer H, Ashcroft FM, Verhaeghe J, Mathieu C, Casteels K Tags: Diabetes Care Source Type: research

Skin preparation for preventing infection following caesarean section.
CONCLUSIONS: This review found that chlorhexidine gluconate compared with iodine alone was associated with lower rates of bacterial growth at 18 hours after caesarean section. However, this outcome was judged as very low quality of evidence. Little evidence is available from the included randomised controlled trials to evaluate different agent forms, concentrations and methods of skin preparation for preventing infection following caesarean section. Therefore, it is not yet clear what sort of skin preparation may be most efficient for preventing postcaesarean wound and surgical site infection.There is a need for high-quali...
Source: Cochrane Database of Systematic Reviews - September 17, 2014 Category: Journals (General) Authors: Hadiati DR, Hakimi M, Nurdiati DS, Ota E Tags: Cochrane Database Syst Rev Source Type: research

Right-sided congenital diaphragmatic hernia in a decade of fetal surgery.
CONCLUSIONS: Right-sided CDH seems to have a poorer outcome than that reported for fetuses with left-sided CDH with similar lung size before birth. Survival rates after expectant management with observed/expected lung-to-head ratio values ≤45 and ≤30% were 17 and 0%, respectively. In those undergoing fetal surgery (observed/expected lung-to-head ratio ≤45%) there was an apparent increase (42%). PMID: 25227954 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - September 17, 2014 Category: OBGYN Authors: DeKoninck P, Gomez O, Sandaite I, Richter J, Nawapun K, Eerdekens A, Ramirez J, Claus F, Gratacos E, Deprest J Tags: BJOG Source Type: research

Researchers Don't See Long-Term Benefits from Drug for Preemies
Magnesium sulfate still useful in short term for helping to reduce risk of cerebral palsy, study says Source: HealthDay Related MedlinePlus Pages: Childbirth Problems, Medicines and Children, Premature Babies (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - September 16, 2014 Category: Consumer Health News Source Type: news

Neonatal Medical Home 'Perfect Fit' After Intensive CareNeonatal Medical Home 'Perfect Fit' After Intensive Care
Preterm babies who are discharged from the intensive care unit receive coordinated care in a neonatal medical home at the University of Kansas Hospital. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 16, 2014 Category: Consumer Health News Tags: Nursing News Source Type: news

National Association of Neonatal Nurses (NANN) 30th Annual Educational ConferenceNational Association of Neonatal Nurses (NANN) 30th Annual Educational Conference
Read clinically focused news coverage of key developments from NANN 2014. Medscape Nurses (Source: Medscape Nurses Headlines)
Source: Medscape Nurses Headlines - September 16, 2014 Category: Nursing Tags: Conference Coverage Source Type: news