Perinatology & Neonatology This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Prediction of Pediatric Outcome after Prenatal Diagnosis and Expectant Antenatal Management of Congenital Cystic Adenomatoid MalformationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fetal Diagn Ther (DOI:10.1159/000331936) (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - February 2, 2012 Category: Perinatology & Neonatology Source Type: research

St. Elizabeth denied NICU unitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
St. Elizabeth Healthcare has been denied Kentucky approval to open an advanced neonatal intensive care unit. The hospital system applied in 2009 for the Level III NICU designation. But it failed to convince the Kentucky Cabinet for Health and Family Services the Kentucky needs the 12-bed service. A spokeswoman for the organization said St. Elizabeth is likely to appeal the decision. St. Elizabeth hoped to lure back the 990 Northern Kentucky women who leave the state to have their babies at Cincinnati Children’s Hospital Medical Center or elsewhere... (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 2, 2012 Category: Pharmaceuticals Authors: James Ritchie Source Type: research

What is the Evidence for the use of Adrenaline in the Treatment of Neonatal Hypotension?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents) - February 2, 2012 Category: Cardiology Authors: Mahoney, LiamCrook, DavidN Walter, KerstinSherman, EllaRabe, Heike Tags: Articles Source Type: research

The Size 1 ProSeal™ laryngeal mask airway in infants: a randomized, noncrossover study with the Classic™ laryngeal mask airwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:  We conclude that the size 1 PLMA is a stable, safe, and efficacious airway control device during neonatal and infant anesthesia, allowing higher peak airway pressure during positive pressure ventilation, with fewer mask displacements and gastric insufflations than the cLMA. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - February 2, 2012 Category: Anesthesiology Authors: Maite López‐GilIgnacio MantillaTeresa BlancoEnrique TeigellMónica HerviasRosa Fernández‐López Tags: ORIGINAL ARTICLE Source Type: research

History of the birth certificate: from inception to the future of electronic dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& S G Golombek (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: H L BrumbergD DozorS G Golombek Tags: history of medicine birth certificate vital statistics Source Type: research

Nasal intermittent positive pressure ventilation after surfactant treatment for respiratory distress syndrome in preterm infantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& R F Soll (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: R RamanathanK C SekarM RasmussenJ BhatiaR F Soll Tags: respiratory distress syndrome surfactant preterm bronchopulmonary dysplasia NIPPV NCPAP Source Type: research

Effect of heparin and other factors associated with complications of peripherally inserted central venous catheters in neonatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& H Akinbi (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: B IsemannR SorrelsH Akinbi Tags: percutaneous central venous catheter occlusion catheter removal Source Type: research

NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restrictionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
urakowski & S K Warfield (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: H AlsF H DuffyG McAnultyS C ButlerL LightbodyS KostaN I WeisenfeldR RobertsonR B ParadS A RingerJ G BlickmanD ZurakowskiS K Warfield Tags: NIDCAP intrauterine growth restriction preterm infants APIB EEG MRI Source Type: research

Does increasing body mass index affect cerclage efficacy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Does increasing body mass index affect cerclage efficacy? Journal of Perinatology advance online publication, February 2, 2012. doi:10.1038/jp.2011.198 Authors: S H Poggi, N A Vyas, J C Pezzullo, H J Landy & A Ghidini (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: S H PoggiN A VyasJ C PezzulloH J LandyA Ghidini Tags: body mass index cerclage cervical insufficiency obesity preterm delivery Source Type: research

Evaluation of cerebrospinal fluid parameters in preterm infants with intraventricular reservoirsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& G Natarajan (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: M BajajM Lulic-BoticaG Natarajan Tags: cerebrospinal fluid preterm infants intraventricular reservoir Source Type: research

Domestic violence screening of obstetric triage patients in a military populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& E F Magann (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 2, 2012 Category: Perinatology & Neonatology Authors: M A LutgendorfA ThagardP D RockswoldJ M BuschE F Magann Tags: domestic violence emergency care military physical abuse pregnancy Source Type: research

Radiological clues to the early diagnosis of hypochondroplasia in the neonatal period: Report of two patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on the clinical and radiological findings in two HCH children with a FGFR3 mutation. In both children, fetal US showed short femora and relatively increased biparietal diameter (BPD). However, postnatal assessment failed to make a specific diagnosis in the neonatal period. The correct diagnosis of HCH was accomplished by reassessment after exacerbation of postnatal short stature. In retrospective radiological review, the radiological findings relevant to HCH were discernible more easily in the neonatal period than at age of 3 years. © 2012 Wiley Periodicals, Inc. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - February 2, 2012 Category: Genetics & Stem Cells Authors: Tomoko SaitoKeisuke NagasakiGen NishimuraMasaki TakagiTomonobu HasegawaMakoto Uchiyama Tags: Clinical Report Source Type: research

Chromosome 22q11.2 duplication is rare in a population‐based cohort of Danish children with cardiovascular malformationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractThe prevalence of the 22q11.2 duplication is unknown in children with cardiovascular malformations (CVMs). As most individuals with the duplication are detected in the search for other conditions, especially the 22q11.2 deletion, CVMs associated with the duplication are subject to referral bias. We circumvented this bias by investigating the prevalence of the 22q11.2 duplication in a population‐based cohort of children with CVMs. The study population was defined as children born in 2000–2008, who were registered in the Danish National Patient Registry with a diagnosis of CVM from one of the two national univers...
Source: American Journal of Medical Genetics Part A - February 2, 2012 Category: Genetics & Stem Cells Authors: Peter AgergaardCharlotte OlesenJohn Rosendahl ØstergaardMichael ChristiansenKarina Meden Sørensen Tags: Research Article Source Type: research

Clinical Characteristics Of Neonates With VACTERL AssociationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractBackground:  The VACTERL association (VA) is the nonrandom co‐occurrence of Vertebral anomalies, Anal atresia, Cardiovascular malformations, Tracheo‐esophageal fistula and/or Esophageal atresia, Renal anomalies, and/or Limb‐anomalies, and is referred to the first letters of its components. Studies investigating the clinical characteristics of VA patients and probing of the observed current six component types are limited, and none of them is focused to neonates. Clinical characteristics of our patients diagnosed as having VA in the newborn period is investigated.Methods:  We retrospectively reviewed the n...
Source: Pediatrics International - February 2, 2012 Category: Pediatrics Authors: Oral AkgunCaner IbrahimYigiter MuratKantarci MecitOlgun HasimCeviz NaciSalman Ahmet Bedii Source Type: research

The neonate presenting with temperature symptoms: Role in the diagnosis of early onset sepsisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:  Every seventh newborn hospitalized at our neonatal intensive care unit developed fever, hypothermia and/or temperature instability during the first three days of life. Two thirds of them had culture proven or clinical sepsis. Temperature symptoms were rarely observed in EOS negative newborns (8%) but despite low sensitivity highly specific for bacterial infection in preterm and term newborns.© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society (Source: Pediatrics International)
Source: Pediatrics International - February 2, 2012 Category: Pediatrics Authors: Nora HoferWilhelm MüllerBernhard Resch Source Type: research

Use of dosulepin in pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: UK Teratology Information Service Area: Evidence > Drugs in Pregnancy SUMMARY: Dosulepin (formerly known as dothiepin) is a tricyclic antidepressant used in the treatment of depression, particularly where sedation is required.  There is very little published data regarding the use of dosulepin in pregnancy.  Neonatal withdrawal symptoms may occur following chronic use or use near the time of delivery of any antidepressant.  The neonate should be monitored for adverse effects such as drowsiness, jitteriness, hyperexcitability and suckling problems.  Some studies have suggested that exposur...
Source: NeLM - Drugs in Pregnancy - February 2, 2012 Category: OBGYN Source Type: news

Risk of Suicide, Self-injury, and Psychiatric Service UseRisk of Suicide, Self-injury, and Psychiatric Service UseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Can perinatal experiences, such as birth complications, predict later mental health problems in children and adolescents? BMC Public Health (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 1, 2012 Category: Consumer Health News Tags: Psychiatry Journal Article Source Type: news

Controlled collagen crosslinking process in tissue‐engineered fibroblast sheets for preventing scar contracture on the surface of lungsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractFor preventing the scar contracture of host tissue and adjusting the tensile strength of covering cell sheets, a controlled collagen crosslinking step process in the preparation of skin‐fibroblast sheets for repairing wound was investigated by using β‐aminopropionitrile (BAPN), a collagen crosslinking inhibitor, in the culture medium. Skin fibroblasts obtained from neonatal rats were cultured in medium with and without 0.25 mm BAPN for 7 days and seeded on temperature‐responsive culture dishes. After the confluent cells were non‐invasively harvested as a monolithic cell sheet, two cell sheets were tran...
Source: Journal of Tissue Engineering and Regenerative Medicine - February 1, 2012 Category: Molecular Biology Authors: Masato KanzakiMasayuki YamatoRyo TakagiTakuma KikkawaTamami IsakaTeruo OkanoTakamasa Onuki Tags: Research Article Source Type: research

Development and validation of serum bilirubin nomogram to predict the absence of risk for severe hyperbilirubinaemia before discharge: a prospective, multicenter studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The hour-specific TSB nomogram is able to predict all neonates without risk of non physiologic hyperbilirubinemia only after 48 to 72 hours of life. The combination of TSB determination and risk factors for hyperbilirubinemia could facilitate a safe discharge from the hospital and a targeted intervention and follow-up. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 1, 2012 Category: Pediatrics Authors: Costantino RomagnoliEloisa TiberiGiovanni BaroneMario De CurtisDaniela RegoliPiermichele PaolilloSimonetta PiconeStefano AnaniaMaurizio FinocchiValentina CardielloLucia GiordanoValentina PaolucciEnrico Zecca Source Type: research

Developmental outcome of very low birth weight infants in a developing countryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although the neurodevelopmental outcome of this group of VLBW infants was within the normal range, with a low incidence of cerebral palsy, these results may reflect the low survival of babies with a birth weight below 900 grams. In addition, mean subscale scores were low and one third of the babies were identified as "at risk", indicating that this group of babies warrants long-term follow up into school going age. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - February 1, 2012 Category: Pediatrics Authors: Daynia BallotJoanne PottertonTobias ChirwaNicole HilburnPeter Cooper Source Type: research

Neonatal Drug WithdrawalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maternal use of certain drugs during pregnancy can result in transient neonatal signs consistent with withdrawal or acute toxicity or cause sustained signs consistent with a lasting drug effect. In addition, hospitalized infants who are treated with opioids or benzodiazepines to provide analgesia or sedation may be at risk for manifesting signs of withdrawal. This statement updates information about the clinical presentation of infants exposed to intrauterine drugs and the therapeutic options for treatment of withdrawal and is expanded to include evidence-based approaches to the management of the hospitalized infant who re...
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Authors: Hudak, M. L., Tan, R. C., THE COMMITTEE ON DRUGS, THE COMMITTEE ON FETUS AND NEWBORN Tags: Therapeutics & Toxicology From the American Academy of Pediatrics Source Type: research

Genetic and Environmental Components of Neonatal Weight Gain in Preterm InfantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This high heritability estimate could suggest using this set of criteria to identify genes that regulate postnatal weight gain or failure. (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Authors: Brescianini, S., Giampietro, S., Cotichini, R., Lucchini, R., De Curtis, M. Tags: Article Source Type: research

Intrapartum Temperature Elevation, Epidural Use, and Adverse Outcome in Term InfantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The proportion of infants experiencing adverse outcomes increased with the degree of epidural-related maternal temperature elevation. Epidural use without temperature elevation was not associated with any of the adverse outcomes we studied. (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Authors: Greenwell, E. A., Wyshak, G., Ringer, S. A., Johnson, L. C., Rivkin, M. J., Lieberman, E. Tags: Premature & Newborn Article Source Type: research

Incidence and Timing of Presentation of Necrotizing Enterocolitis in Preterm InfantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Among infants <33 weeks’ gestation, NEC appears to present at mean age of 7 days in more mature infants, whereas onset of NEC is delayed to 32 days of age in smaller, lower GA infants. Further studies are required to understand the etiology of this disease process. (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Authors: Yee, W. H., Soraisham, A. S., Shah, V. S., Aziz, K., Yoon, W., Lee, S. K., the Canadian Neonatal Network Tags: Premature & Newborn Article Source Type: research

Genetic and Environmental Components of Neonatal Weight Gain in Preterm InfantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several studies have focused on birth weight heritability, reporting results that range between 40% and 80%. Few studies have focused on the process of weight gain and were mainly based on heterogeneous samples of infants. The present work looks at a uniform set of healthy preterm newborn twins. The resulting high heritability estimate could suggest using the inclusion criteria to identify genes that regulate postnatal weight gain or failure. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Intrapartum Temperature Elevation, Epidural Use, and Adverse Outcome in Term InfantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previous observational studies and randomized trials have reported an association between the use of epidural analgesia for pain relief in labor and intrapartum maternal fever. Studies have also reported an increase in adverse neonatal outcomes with intrapartum maternal fever. Among low-risk women receiving epidural analgesia, intrapartum maternal temperature >99.5°F was associated with adverse neonatal outcomes, with the rate of adverse outcomes increasing directly with maximum maternal temperature. Without temperature elevation, epidural use was not associated with adverse neonatal outcomes. (Read the full article...
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Index of Suspicion in the Nursery * Case 1: Bloody Stool at 1 Day of Age in a Term Newborn * Case 2: Abnormal Fetal Movements and Early Neonatal CollapseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2012 Category: Pediatrics Authors: Marron-Corwin, M., Passi, R., Chandel, A., Cooper, A., Abdelhamid, A. Tags: Fetus and Newborn Infant Articles Source Type: news

Future Directions in the Evaluation and Management of Neonatal SepsisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although sepsis is one of the important etiologies of illness in hospitalized infants, it is often difficult to determine if an infant is truly infected and, moreover, how to treat these infections. To address the first issue, researchers have begun to examine techniques to shorten the amount of time it takes to culture and identify organisms. On the clinical side, the development of biomarkers may help physicians to better identify infants who are likely ill from infection versus those infants who are unstable from other processes. The ability to distinguish between these cohorts will help to curtail excessive use of empi...
Source: NeoReviews recent issues - February 1, 2012 Category: Pediatrics Authors: Bhatti, M., Chu, A., Hageman, J. R., Schreiber, M., Alexander, K. Tags: Fetus and Newborn Infant Articles Source Type: news

Topics in Neonatal Informatics: Optimal Clinical Data Entry, DisplayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Displaying the vast amount of clinical data that exist in electronic medical records without causing information overload or interfering with provider thought processes is a challenge. To support the transformation of data into information and knowledge, effective electronic displays must be flexible and guide physicians’ thought processes. Applying research from cognitive science and human factors engineering offers promise in improving the electronic display of clinical information. (Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2012 Category: Pediatrics Authors: Palma, J. P., Brown, P. J., Lehmann, C. U., Longhurst, C. A. Tags: Fetus and Newborn Infant Articles Source Type: news

International Perspectives: Neonatal Jaundice: Building a Culture of Safety (An Argentinean Perspective)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - February 1, 2012 Category: Pediatrics Authors: Martinez, J. C. Tags: Fetus and Newborn Infant Articles Source Type: news

Multifocal haemorrhagic brain damage following hypoxia and blood pressure lability: case report and rat modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that transient hypoxia, in a dose‐dependent manner, can weaken the vasculature and predispose to brain haemorrhage in the situation of labile blood pressure. Persistent hypoxia is likely to be important in the genesis of permanent severe brain damage.© 2012 The Authors. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - February 1, 2012 Category: Neurology Authors: Payam S. PahlavanWesley SuttonRichard J. BuistMarc R. Del Bigio Source Type: research

Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Severe hypoxemia and higher BMI on admission were associated with adverse outcomes for pregnant women. Preterm delivery was a risk factor for neonatal death among pregnant women with pH1N1 influenza infection. NIV may be useful in selected pregnant women without septic shock. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 1, 2012 Category: Infectious Diseases Authors: Peng-jun ZhangXiao-li LiBin CaoShi-gui YangLi-rong LiangLi GuZhen XuKe HuHong-yuan ZhangXi-xin YanWen-bao HuangWei ChenJing-xiao ZhangLan-juan LiChen Wang Source Type: research

Child mortality in India: a complex situation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Apart from raising awareness among community leaders, family members responsible for care giving should be specially targeted for removal of hostile perceptions and barriers for improvement of child survival. Also there is need for developing new strategies for health education based on indigenous concerns, addressing socio-cultural barriers. PMID: 22282378 [PubMed - in process] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - February 1, 2012 Category: Pediatrics Authors: Ghosh R Tags: World J Pediatr Source Type: research

Understanding Bartter syndrome and Gitelman syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Patients with Bartter syndrome types 1, 2 and 4 present at a younger age than classic Bartter syndrome type 3. They present with sypmtoms, often quite severe in the neonatal period. Patients with classic Bartter syndrome type 3 present later in life and may be sporadically asymptomatic or mildly symptomatic. The severe, steady-state hypokalemia in Bartter syndrome and Gitelman syndrome may abruptly become lifethreatening under certain aggravating conditions. Clinicians need to be cognizant of such renal tubular disorders, and promptly treat at-risk patients. PMID: 22282380 [PubMed - in process] (Source: Wo...
Source: World Journal of Pediatrics : WJP - February 1, 2012 Category: Pediatrics Authors: Fremont OT, Chan JC Tags: World J Pediatr Source Type: research

Preventing maternal and neonatal harm during vacuum-assisted vaginal delivery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Nursing assessment and interventions can make all the difference.The Pennsylvania Patient Safety Reporting System is a confidential, statewide Internet reporting system to which all Pennsylvania hospitals, outpatient-surgery facilities, and birthing centers, as well as some abortion facilities, must file information on medical errors.Safety Monitor is a column from Pennsylvania's Patient Safety Authority, the authority that informs nurses on issues that can affect patient safety and presents strategies they can easily integrate into practice. For more information on the authority, visit www.patientsafetyau...
Source: The American Journal of Nursing - February 1, 2012 Category: Nursing Authors: Lacker C Tags: Am J Nurs Source Type: research

Hypoxic Pulmonary VasoconstrictionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last 20 years, it has been clear that the essential sensor, transduction, and effector mechanisms responsible for hypoxic pulmonary vasoconstriction (HPV) reside in the pulmonary arterial smooth muscle cell. The main focus of this review is the cellular and molecular work performed to clarify these intrinsic mechanisms and to determine how they are facilitated and inhibited by the extrinsic influences of other cells. Because the interaction of intrin...
Source: Physiological Reviews - January 31, 2012 Category: Physiology Authors: Sylvester, J. T., Shimoda, L. A., Aaronson, P. I., Ward, J. P. T. Tags: Articles Source Type: research

Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice [Medical Sciences]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maintenance of skeletal muscle structure and function requires efficient and precise metabolic control. Autophagy plays a key role in metabolic homeostasis of diverse tissues by recycling cellular constituents, particularly under conditions of caloric restriction, thereby normalizing cellular metabolism. Here we show that histone deacetylases (HDACs) 1 and 2 control skeletal muscle homeostasis and autophagy flux in mice. Skeletal muscle-specific deletion of both HDAC1 and HDAC2 results in perinatal lethality of a subset of mice, accompanied by mitochondrial abnormalities and sarcomere degeneration. Mutant mice that survive...
Source: Proceedings of the National Academy of Sciences - January 31, 2012 Category: Science Authors: Moresi, V., Carrer, M., Grueter, C. E., Rifki, O. F., Shelton, J. M., Richardson, J. A., Bassel-Duby, R., Olson, E. N. Tags: Biological Sciences Source Type: research

Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance [Immunology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In healthy individuals, T cells react against incoming pathogens, but remain tolerant to self-antigens, thereby preventing autoimmune reactions. CD4 regulatory T cells are major contributors in induction and maintenance of peripheral tolerance, but a regulatory role has been also reported for several subsets of CD8 T cells. To determine the molecular basis of peripheral CD8 T-cell tolerance, we exploited a double transgenic mouse model in which CD8 T cells are neonatally tolerized following interaction with a parenchymal self-antigen. These tolerant CD8 T cells have regulatory capacity and can suppress T cells in an antige...
Source: Proceedings of the National Academy of Sciences - January 31, 2012 Category: Science Authors: Papatriantafyllou, M., Moldenhauer, G., Ludwig, J., Tafuri, A., Garbi, N., Hollmann, G., Kublbeck, G., Klevenz, A., Schmitt, S., Pougialis, G., Niehrs, C., Grone, H.–J., Hammerling, G. J., Arnold, B., Oelert, T. Tags: Biological Sciences Source Type: research

Efficacy of Phototherapy for Newborns with Hyperbilirubinemia: A Cautionary Example of an Instrumental Variable AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Instrumental variable analyses may provide biased estimates of treatment efficacy if there are cointerventions or confounders associated with treatment at the level of the instrument, although even when these associations may not exist in individuals. (Source: Medical Decision Making)
Source: Medical Decision Making - January 31, 2012 Category: Health Management Authors: Newman, T. B., Vittinghoff, E., McCulloch, C. E. Tags: Original Articles Source Type: research

Rheumatic Heart Disease in Pregnancy – cardiac and obstetric outcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:  RHD has a major impact on maternal cardiac outcomes. However, with current management practices maternal and fetal mortality are low, and the incidence of complications is predictable based on known risk factors. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 31, 2012 Category: Internal Medicine Authors: James B SartainNicole L AndersonJohn J BarryPeter T BoydPaul W Howat Source Type: research

Sustained response and prevention of damage progression in patients with neonatal‐onset multisystem inflammatory disease (NOMID) treated with anakinraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:Anakinra provides sustained efficacy in the treatment of NOMID for up to five years, with the requirement of dose escalation. Damage progression in the CNS, ear, and eye – but not bone – is preventable. Anakinra is overall well tolerated. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 31, 2012 Category: Rheumatology Authors: Cailin H. SibleyNikki PlassJoseph SnowEdythe WiggsCarmen BrewerKelly KingChristopher ZalewskiH. Jeffrey KimRachel BishopSuvimol HillPatrick KickerZackary PhillipsJoseph G. DolanBrigitte WidemannNalini JayaprakashFrank PucinoDeborah StoneDawn ChapelleChris Tags: Full Length Source Type: research

Choroid Plexus Carcinoma: Prenatal Characterization by 3-Dimensional Sonography and Magnetic Resonance Imaging, Perinatal Management, and Natural HistoryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - January 31, 2012 Category: Radiology Authors: Vassallo, M., Giuseppe, M. M., Quarantelli, M., Pastore, G., Paladini, D. Tags: Clinical Letters Source Type: research

Adaptive Changes in the Splenic Artery and Left Portal Vein in Fetal Growth RestrictionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions— Reduced blood flow through the left portal vein and low resistance in the splenic artery can be found in growth-restricted fetuses with adverse neonatal outcomes. (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - January 31, 2012 Category: Radiology Authors: Vedmedovska, N., Rezeberga, D., Teibe, U., Zodzika, J., Donders, G. G. G. Tags: Original Research Source Type: research

Mean cerebral blood flow measurements using phase contrast MRI in the first year of lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, mean global CBF was measured in 21 infants under the age of one, using non‐invasive MRI techniques adapted to the neonatal population. Mean CBF was computed as the ratio of blood flow delivered to the brain (measured using phase contrast MRI) and brain volume (computed by segmenting anatomical MR images). Tests in adult volunteers and repeated measurements showed the flow measurements using the proposed method to be both accurate and reproducible. It was also found that cardiac gating need not be employed in infants with no known cardiac pathology.The developed technique can easily be appended to a neonata...
Source: NMR in Biomedicine - January 31, 2012 Category: Radiology Authors: Marta VarelaAlan M GrovesTomoki ArichiJoseph V Hajnal Tags: Research Article Source Type: research

Blockage of the afferent sensitive pathway prevents sympathetic atrophy and hemodynamic alterations in rat portal hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionThese results indicate that the nervous system has a central role in the genesis of the circulatory abnormalities of portal hypertension, and support that mesenteric sympathetic atrophy contributes to splanchnic arterial vasodilation. (Source: Liver International)
Source: Liver International - January 31, 2012 Category: Gastroenterology Authors: Nahia EzkurdiaMar CollImma RaurellSarai RodriguezSilvia CuencaAntonio GonzálezJaime GuardiaRafael EstebanJoan GenescàMaría Martell Tags: Basic Studies Source Type: research

Inhibition of Na+‐H+ exchange as a mechanism of rapid cardioprotection by resveratrolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions and Implications.  Resveratrol exerts cardioprotection by reducing ROS and preserving mitochondrial function. The PKC‐α‐dependent inhibition of NHE and subsequent attenuation of [Ca2+]i overload may be a cardioprotective mechanism. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - January 31, 2012 Category: Drugs & Pharmacology Authors: Luong Cong ThucYasushi TeshimaNaohiko TakahashiSatoru NishioAkira FukuiOsamu KumeShotaro SaitoMikiko NakagawaTetsunori Saikawa Source Type: research

Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete β‐globin gene clusterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report and define a 198 kb deletion removing the entire β‐globin gene cluster, which was found in members of a multigeneration family of Irish/Scottish descent. The proband had life‐threatening fetal and neonatal hemolytic anemia which subsided by 1 year of age. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - January 31, 2012 Category: Cancer & Oncology Authors: Madeleine VerhovsekNirmish R. ShahIbifiri WilcoxSara C. KoenigTiago BarrosCourtney D. ThornburgMartin H. SteinbergHong‐yuan LuoDavid H.K. Chui Tags: Brief Report Source Type: research

Foot anomalies and proximal symphalangismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 2‐week‐old girl born at term (by vaginal delivery and without antenatal or perinatal events) who was referred as having “bilateral talipes and bilateral proximal symphalangism of little and ring fingers.” The “talipes” was atypical with marked equinus and varus, but no cavus or adductus of the midfoot. Her mother had both symphalangism (absence of proximal interphalangeal joints) of middle, ring, and little fingers bilaterally and fixed pes planus with a rigid fixed hindfoot—and these deformities had also been present from birth. The maternal grandmother was similarly affected. However...
Source: Clinical Anatomy - January 31, 2012 Category: Anatomy Authors: Lauren ShawJanet McCaulGreg J. IrwinJames S. Huntley Tags: Problems in Diagnostic Imaging Source Type: research

The impact of neonatal breast-feeding on growth trajectories of youth exposed and unexposed to diabetes in utero: the EPOCH StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ie & D Dabelea (Source: International Journal of Obesity)
Source: International Journal of Obesity - January 31, 2012 Category: Eating Disorders and Weight Management Authors: T L CrumeL G OgdenE J Mayer-DavisR F HammanJ M NorrisK J BischoffR McDuffieD Dabelea Tags: gestational diabetes fetal exposure to diabetes breast-feeding childhood obesity childhood growth trajectories Source Type: research

Proportion of Parents Agreeing to Delay Fetal Karyotyping until the Third Trimester of Pregnancy in Cases with an IndicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fetal Diagn Ther (DOI:10.1159/000334067) (Source: Fetal Diagnosis and Therapy)
Source: Fetal Diagnosis and Therapy - January 30, 2012 Category: Perinatology & Neonatology Source Type: research