Physiology 
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Science Weekly podcast: Transplants and the future of intensive care
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This week, we're focusing on some pivotal stories from the history of science and medicine. First up are human-to-human transplants and intensive care medicine. These are among the greatest successes of post-war medicine, but they also raise some of the most profound ethical questions. Ahead of a discussion at the Royal Institution in London, Kevin Fong, an anaesthetist and physiology lecturer at University College London, and medical historian Richard Barnett came into the studio to discuss how these important medical interventions started and, crucially, where they are heading. The debates will be held at the Royal Insti...
Source: Guardian Unlimited Science - February 6, 2012 Category: Science Authors: Alok Jha, Iain Chambers, Kevin Fong, Robin McKie Tags: Medical research Anthropology Science Health Society Bird flu Ethics guardian.co.uk Editorial Source Type: news
The Risk Of Colon Cancer Could Be Reduced By Regular Use Of Vitamin And Mineral SupplementsEmail this article to a colleague.
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Could the use of vitamin and mineral supplements in a regular diet help to reduce the risk of colon cancer and protect against carcinogens? A study published in the Canadian Journal of Physiology and Pharmacology (CJPP) found that rats given regular multivitamin and mineral supplements showed a significantly lower risk of developing colon cancer when they were exposed to carcinogens. "It has been unclear whether multivitamin supplementation to cancer patients is helpful, has no effect, or is even detrimental during therapy," commented Dr. Grant Pierce, Editor of CJPP... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 6, 2012 Category: Consumer Health News Tags: Colorectal Cancer Source Type: news
Comparing Identical Twins DNA Reveals Mechanics Behind AgingEmail this article to a colleague.
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(Ivanhoe Newswire) James D. Watson, Frances Crick, and Maurice Wilkins were awarded the Nobel Prize in Physiology or Medicine in 1962 for their discovery of the structure of DNA. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - February 6, 2012 Category: Consumer Health News Source Type: news
Rupert Sheldrake: the 'heretic' at odds with scientific dogmaEmail this article to a colleague.
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Rupert Sheldrake has researched telepathy in dogs, crystals and Chinese medicine in his quest to explore phenomena that science finds hard to explainIt is not often, in liberal north London, that you come face to face with a heretic, but Rupert Sheldrake has worn that mantle, pretty cheerfully, for 30 years now. Sitting in his book-lined study, overlooking Hampstead Heath, he appears a highly unlikely candidate for apostasy; he seems more like the Cambridge biochemistry don he once was, one of the brightest Darwinians of his generation, winner of the university botany prize, researcher at the Royal Society, Harvard scholar...
Source: Guardian Unlimited Science - February 4, 2012 Category: Science Authors: Tim Adams Tags: Controversies in science Richard Dawkins Evolution Biology Science and nature Books Culture The Observer Interviews Features Source Type: news
Myeloid Elf‐1‐like factor stimulates adipogenic differentiation through the induction of peroxisome proliferator‐activated receptor γ expression in bone marrowEmail this article to a colleague.
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AbstractMyeloid Elf‐1 like factor (MEF) is one of the Ets transcription factors known to regulate cell proliferation and differentiation. A previous report has shown that osteoblast‐specific MEF transgenic mice (Col1a1‐MEF‐TG mice) have low bone mass but high bone marrow adiposity. In the present study, we explored a previously unappreciated mechanism whereby MEF promotes adipogenesis in bone marrow. An adipogenic colony forming unit assay showed that bone marrow cells derived from Col1a1‐MEF‐TG mice had a higher adipogenic differentiation potential compared to those from wild‐type. The levels of adipogenic m...
Source: Journal of Cellular Physiology - February 4, 2012 Category: Cytology Authors: Kyunghwa BaekJe‐Yoel ChoHyo Rin HwangArang KwonHye‐Lim LeeHyun‐Jung ParkAbdul S QadirHyun‐Mo RyooKyung Mi WooJeong‐Hwa Baek Tags: Original Research Article Source Type: research
CorrigendumEmail this article to a colleague.
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(Source: Acta Physiologica)
Source: Acta Physiologica - February 3, 2012 Category: Physiology Tags: Corrigendum Source Type: research
Getting a kick out of thermoregulationEmail this article to a colleague.
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(Source: Acta Physiologica)
Source: Acta Physiologica - February 3, 2012 Category: Physiology Authors: A. Bondke PerssonP. B. Persson Tags: EDITORIAL Source Type: research
Carl Friedrich Wilhelm Ludwig, a fabled physiologist and mentor of Scandinavian Physiology Announcing the Carl Ludwig Award for young authors in Acta Physiologica (Oxford)Email this article to a colleague.
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(Source: Acta Physiologica)
Source: Acta Physiologica - February 3, 2012 Category: Physiology Authors: Pontus B. Persson Tags: EDITORIAL Source Type: research
Regular use of vitamin and mineral supplements could reduce the risk of colon cancer, study suggestsEmail this article to a colleague.
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Could the use of vitamin and mineral supplements in a regular diet help to reduce the risk of colon cancer and protect against carcinogens? A study published in the Canadian Journal of Physiology and Pharmacology found that rats given regular multivitamin and mineral supplements showed a significantly lower risk of developing colon cancer when they were exposed to carcinogens. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 3, 2012 Category: Science Source Type: news
Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissuesEmail this article to a colleague.
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This study postulates that this CRT is developmentally regulated in the rat cochlea. CRT expression
was measured by quantitative real-time RT-PCR and immunohistochemistry in the postnatal (P0–P14) and adult (P22–P56) rat cochlea.
The maximum CRT expression was reached at the onset of hearing (P12), and this level was maintained through to adulthood.
CRT immunoreactivity was strongest in the sensory inner hair cells, supporting cells and the spiral ganglion neurons. Cochlear
distribution of the CK brain isoform (CKB) was also assessed by immunohistochemistry and compared with the distribution of
CRT in the developi...
Source: Histochemistry and Cell Biology - February 3, 2012 Category: Biomedical Science Tags: Histochemistry and Cell Biology Source Type: research
Role of leptin as antioxidant in obstructive sleep apnea: an in vitro study using electron paramagnetic resonance methodEmail this article to a colleague.
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Conclusion Leptin is an antioxidant agent of possible use as a marker of OS and future risk of atherosclerotic disease in OSA.
Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s11325-012-0656-8Authors
Madalina Macrea, Salem VA Medical Center, affiliate of the University of Virginia School of Medicine, Charlottesville, VA, USAThomas Martin, Salem VA Medical Center, affiliate of the University of Virginia School of Medicine, Charlottesville, VA, USALeon Zagrean, Physiology Department, “Carol Davila” School of Medicine, Bucharest, RomaniaZhenquan Jia, Department of Biology, Uni...
Source: Sleep and Breathing - February 3, 2012 Category: Respiratory Medicine Tags: Sleep and Breathing Source Type: research
Methods for the Assessment of Small-Bowel and Colonic TransitEmail this article to a colleague.
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Transit assessment of the small intestine and colon is relevant in the study of physiology, pathophysiology, and pharmacodynamics, and there is increasing use of small-bowel and colonic transit measurements in clinical practice as well. The main methods that are applied in clinical practice are substrate-hydrogen breath tests for small-bowel transit and radiopaque markers for colonic transit. Over the past 2-3 decades, scintigraphy has become the preferred standard in research studies, particularly for studies of pathophysiology and pharmacodynamics. New approaches include experimental stable isotope measurement of oroceca...
Source: Seminars in Nuclear Medicine - February 3, 2012 Category: Radiology Authors: Lawrence A. Szarka, Michael Camilleri Source Type: research
Blood metabolite data in response to maximal exercise in healthy subjectsEmail this article to a colleague.
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SummaryMaximal exercise test with gas exchange measurement evaluates exercise capacities with maximal oxygen uptake (VO2max) measurement. Measurements of lactate (L), lactate/pyruvate ratio (L/P) and ammonium (A) during rest, exercise and recovery enhance interpretative power of maximal exercise by incorporating muscular metabolism exploration. Maximal exercise test with gas exchange measurement is standardized in cardiopulmonary evaluations but, no reference data of blood muscular metabolites are available to evaluate the muscular metabolism. We determined normal values of L, L/P and A during a standardized maximal exerci...
Source: Clinical Physiology and Functional Imaging - February 3, 2012 Category: Radiology Authors: Amèle MouadilClaire DeboutMarie‐Hélène ReadRémy MorelloStéphane AlloucheFrançoise Chapon Tags: Original Article Source Type: research
Sepsis-induced acute kidney injury—is there a lack of energy?Email this article to a colleague.
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Content Type Journal ArticleCategory EditorialPages 1-3DOI 10.1007/s00134-012-2489-0Authors
Robert Frithiof, Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden
Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - February 3, 2012 Category: Intensive Care Tags: Intensive Care Medicine Source Type: research
Measuring glomerular filtration rate from plasma clearance of 51Cr-EDTA: quality assuranceEmail this article to a colleague.
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Content Type Journal ArticleCategory Editorial CommentaryPages 1-2DOI 10.1007/s00259-012-2073-4Authors
Michael Rehling, Department of Clinical Physiology and Nuclear Medicine, Århus University Hospital, Skejby, DK-8200 Århus N, Denmark
Journal European Journal of Nuclear Medicine and Molecular ImagingOnline ISSN 1619-7089Print ISSN 1619-7070 (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 3, 2012 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: research
Development and Implementation of a Web-Enabled 3D Consultation Tool for Breast Augmentation Surgery Based on 3D-Image Reconstruction of 2D PicturesEmail this article to a colleague.
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Conclusions: We tested our tool for 3D, Web-based, patient-specific consultation in the clinical scenario of breast augmentation. This example shows that the current state of development allows for creation of responsive and effective Web-based, 3D medical tools, even with highly complex and time-consuming computation, by off-loading them to a dedicated high-performance data center. The efficient combination of advanced technologies, based on analysis and understanding of human anatomy and physiology, will allow the development of further Web-based reconstruction and predictive interfaces at different scales of the human b...
Source: Journal of Medical Internet Research - February 3, 2012 Category: Journals (General) Authors: Pablo de Heras CiechomskiMihai ConstantinescuJaime GarciaRadu OlariuIrving DindoyalSerge Le HuuMauricio Reyes Source Type: research
Mechanism of association between BMI and dysfunction of the gastro-oesophageal barrier in patients with normal endoscopyEmail this article to a colleague.
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Conclusion
The association between reflux and BMI may be largely explained by effects of increased intra-abdominal pressure. However, the reduced LOS pressure associated with BMI may be mediated by another mechanism or effects of chronic rather than acute elevation of intra-abdominal pressure. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Derakhshan, M. H., Robertson, E. V., Fletcher, J., Jones, G.-R., Lee, Y. Y., Wirz, A. A., McColl, K. E. L. Tags: Oesophagus Source Type: research
Metabolic characteristics of human subcutaneous abdominal adipose tissueafter overnight fastEmail this article to a colleague.
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We examined within-person variability. Systemic NEFA concentrations, NEFA release, fatty acid re-esterification, and adipose tissue blood flow were all more consistent within than between individuals. This picture of human adipose tissue metabolism in the fasted state should contribute to a greater understanding of adipose tissue physiology and pathophysiology. (Source: AJP: Endocrinology and Metabolism)
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Frayn, K. N., Humphreys, S. M. Tags: Articles Source Type: research
Gadd45a and Gadd45b modulate innate immune functions of granulocytes and macrophages by differential regulation of p38 and JNK signalingEmail this article to a colleague.
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This study shows that mice lacking either Gadd45a or Gadd45b are defective in the recruitment of granulocytes and macrophages to the intra‐peritoneal cavity following intra‐peritoneal administration of the bacterial cell‐wall PAMP lipopolysaccharide (LPS). Bone marrow (BM) derived granulocytes and macrophages lacking either Gadd45a or Gadd45b are shown to be impaired in their chemotactic response to LPS, as well as other inflammatory stimuli such as fMLP and IL‐8. Evidence was obtained also implicating Gadd45a and Gadd45b in other myeloid innate immune functions, including ROS production, phagocytosis, and adhesion...
Source: Journal of Cellular Physiology - February 3, 2012 Category: Cytology Authors: Dominic M. SalernoJennifer S. TrontBarbara HoffmanDan A. Liebermann Tags: Original Research Article Source Type: research
CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cellsEmail this article to a colleague.
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AbstractTumor metastasis to bone is a serious pathological situation that causes severe pain, and deterioration in locomoter function. However, the mechanisms underlying tumor metastasis is still incompletely understood. CIZ/NMP4 is a nucleocytoplasmic shuttling protein and its roles in tumor cells have not been known. We, therefore, hypothesized the role of CIZ/NMP4 in B16 melanoma cells that metastasize to bone. CIZ/NMP4 is expressed in B16 cells. The CIZ/NMP4 expression levels are correlated to the metastatic activity in divergent types of melanoma cells. Overexpression of CIZ/NMP4increased B16 cell migration in Trans...
Source: Journal of Cellular Physiology - February 3, 2012 Category: Cytology Authors: Tomomi SakumaTetsuya NakamotoHiroaki HemmiSohei KitazawaRiko KitazawaTakuya NotomiTadayosi HayataYoichi EzuraTeruo AmagasaMasaki Noda Tags: Rapid Communication Source Type: research
PI3K‐independent AKT activation in cancers: A treasure trove for novel therapeuticsEmail this article to a colleague.
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AbstractAKT/PKB serine threonine kinase, a critical signaling molecule promoting cell growth and survival pathways, is frequently dysregulated in many cancers. Although phosphatidylinositol‐3‐OH kinase (PI3K), a lipid kinase, is well characterized as a major regulator of AKT activation in response to a variety of ligands, recent studies highlight a diverse group of tyrosine (Ack1/TNK2, Src, PTK6) and serine/threonine (TBK1, IKBKE, DNAPKcs) kinases that activate AKT directly to promote its pro‐proliferative signaling functions. While some of these alternate AKT activating kinases respond to growth factors, others resp...
Source: Journal of Cellular Physiology - February 3, 2012 Category: Cytology Authors: Kiran MahajanNupam P. Mahajan Tags: Review Article Source Type: research
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(Source: AJP: Cell Physiology)
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Tags: CORRIGENDUM Source Type: research
Toll-like receptor deficiency worsens inflammation and lymphedema after lymphatic injuryEmail this article to a colleague.
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In conclusion, TLR deficiency worsens tissue responses to lymphatic fluid stasis and is associated with decreased lymphangiogenesis, increased fibrosis, and reduced macrophage infiltration. These findings suggest a role for innate immune responses, including TLR signaling, in lymphatic repair and lymphedema pathogenesis. (Source: AJP: Cell Physiology)
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Zampell, J. C., Elhadad, S., Avraham, T., Weitman, E., Aschen, S., Yan, A., Mehrara, B. J. Tags: VASCULAR BIOLOGY Source Type: research
Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14Email this article to a colleague.
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Homozygous ataxic mice (axJ) express reduced levels of the deubiquitinating enzyme Usp14. They develop severe tremors by 2–3 wk of age, followed by hindlimb paralysis, and death by 6–8 wk. While changes in the ubiquitin proteasome system often result in the accumulation of ubiquitin protein aggregates and neuronal loss, these pathological markers are not observed in the axJ mice. Instead, defects in neurotransmission were observed in both the central and peripheral nervous systems of axJ mice. We have now identified several new alterations in peripheral neurotransmission in the axJ mice. Using the two-microelec...
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Bhattacharyya, B. J., Wilson, S. M., Jung, H., Miller, R. J. Tags: NERVOUS SYSTEM CELL BIOLOGY Source Type: research
H-Ras isoform modulates extracellular matrix synthesis, proliferation, and migration in fibroblastsEmail this article to a colleague.
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Ras GTPases are ubiquitous plasma membrane transducers of extracellular stimuli. In addition to their role as oncogenes, Ras GTPases are key regulators of cell function. Each of the Ras isoforms exhibits specific modulatory activity on different cellular pathways. This has prompted researchers to determine the pathophysiological roles of each isoform. There is a proven relationship between the signaling pathways of transforming growth factor-β1 (TGF-β1) and Ras GTPases. To assess the individual role of H-Ras oncogene in basal and TGF-β1-mediated extracellular matrix (ECM) synthesis, proliferation, and migrat...
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Fuentes-Calvo, I., Blazquez-Medela, A. M., Eleno, N., Santos, E., Lopez-Novoa, J. M., Martinez-Salgado, C. Tags: EXTRACELLULAR MATRIX, CELL INTERACTIONS Source Type: research
L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N-myc downstream regulated gene 1 in prostate carcinoma cellsEmail this article to a colleague.
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l-Mimosine, an iron chelator and a prolyl 4-hydroxylase inhibitor, blocks many cancer cells at the late G1 phase. B-cell translocation gene 2 (Btg2) regulates the G1/S transition phases of the cell cycle. N-myc downstream regulated gene 1 (Ndrg1) is a differentiation-inducing gene upregulated by hypoxia. We evaluated the molecular mechanisms of l-mimosine on cell cycle modulation in PC-3 and LNCaP prostate carcinoma cells. The effect of l-mimosine on cell proliferation of prostate carcinoma cells was determined by the [3H]thymidine incorporation and flow cytometry assays. l-Mimosine arrested the cell cycle at the G1 phase ...
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Chung, L.-C., Tsui, K.-H., Feng, T.-H., Lee, S.-L., Chang, P.-L., Juang, H.-H. Tags: GROWTH, DIFFERENTIATION, AND APOPTOSIS Source Type: research
Estradiol attenuates high glucose-induced endothelial nitrotyrosine: role for neuronal nitric oxide synthaseEmail this article to a colleague.
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In this study, we examined the endothelial effects of estrogen under increasing glucose levels, focusing on nitrotyrosine and peroxynitrite. Human umbilical vein endothelial cells were incubated with normal (5.5 mM) or high (15.5 or 30.5 mM) glucose before addition of estradiol (E2, 1 or 10 nM). Selective NO synthase (NOS) inhibitors were used to determine the role of specific NOS isoforms. Addition of E2 significantly reduced high glucose-induced increase in peroxynitrite and consequently, nitrotyrosine. The superoxide levels were unchanged, suggesting effects on NO generation. Inhibition of neuronal NOS (nNOS) reduced hi...
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Chakrabarti, S., Cheung, C. C., Davidge, S. T. Tags: VASCULAR BIOLOGY Source Type: research
A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinasesEmail this article to a colleague.
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Vulnerable plaque remains clinically undetectable, and there is no accepted in vitro model. We characterize the calcific nodules produced by calcifying vascular cells (CVC) in ApoE-null mice, demonstrating increased destabilization of cultured nodules in the presence of oxidized low-density lipoprotein (oxLDL) and monocytes under pulsatile shear stress. CVC implanted in the subcutaneous space of hyperlipidemic mice produced nodules revealing features of calcific atherosclerotic plaque including a fibrous cap, cholesterol clefts, thin shoulder, lipids, and calcium mineral deposits. CVC nodules seeded in the pulsatile flow c...
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Li, R., Mittelstein, D., Lee, J., Fang, K., Majumdar, R., Tintut, Y., Demer, L. L., Hsiai, T. K. Tags: VASCULAR BIOLOGY Source Type: research
Potential role of insulin signaling on vascular smooth muscle cell migration, proliferation, and inflammation pathwaysEmail this article to a colleague.
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To investigate the role of insulin signaling pathways in migration, proliferation, and inflammation of vascular smooth muscle cells (VSMCs), we examined the expression of active components of the phosphatidyl inositol 3 (PI-3) kinase (p-Akt) and mitogen-activated protein kinase (MAPK) (p-Erk) in primary cultures of VSMCs from human coronary arteries. VSMCs were treated in a dose-response manner with insulin (0, 1, 10, and 100 nM) for 20 min, and Akt and Erk phosphorylation were measured by Western blot analysis. In separate experiments, we evaluated the effect of 200 μM palmitate, in the presence and absence of 8 μM ...
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Cersosimo, E., Xu, X., Musi, N. Tags: VASCULAR BIOLOGY Source Type: research
Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOXEmail this article to a colleague.
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Suicidal death of erythrocytes, or eryptosis, is characterized by cell shrinkage and cell membrane scrambling leading to phosphatidylserine exposure at the cell surface. Eryptosis is triggered by increase of cytosolic Ca2+ activity, which may result from treatment with the Ca2+ ionophore ionomycin or from energy depletion by removal of glucose. The present study tested the hypothesis that phosphatidylserine exposure at the erythrocyte surface fosters adherence to endothelial cells of the vascular wall under flow conditions at arterial shear rates and that binding of eryptotic cells to endothelial cells is mediated by the t...
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Borst, O., Abed, M., Alesutan, I., Towhid, S. T., Qadri, S. M., Foller, M., Gawaz, M., Lang, F. Tags: RECEPTORS AND SIGNAL TRANSDUCTION Source Type: research
Eryptotic red blood cell adhesion to vascular endothelium: CXCL16/SR-PSOX, a pathological amplifier. Focus on "Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX"Email this article to a colleague.
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(Source: AJP: Cell Physiology)
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Lauf, P. K. Tags: EDITORIAL FOCUS Source Type: research
Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal functionEmail this article to a colleague.
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In skeletal muscle, two major types of muscle fibers exist: slow-twitch oxidative (type I) fibers designed for low-intensity long-lasting contractions, and fast-twitch glycolytic (type II) fibers designed for high-intensity short-duration contractions. Such a wide range of capabilities has emerged through the selection across fiber types of a narrow set of molecular characteristics suitable to achieve a specific contractile phenotype. In this article we review evidence supporting the existence of distinct functional phenotypes in mitochondria from slow and fast fibers that may be required to ensure optimal muscle function....
Source: AJP: Cell Physiology - February 3, 2012 Category: Cytology Authors: Picard, M., Hepple, R. T., Burelle, Y. Tags: REVIEW Source Type: research
AMPKα2 is an essential signal in the regulation of insulin‐stimulated fatty acid uptake in control‐fed and high fat‐fed miceEmail this article to a colleague.
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Abstract Because of its critical role in the regulation of skeletal muscle metabolism, AMP‐activated protein kinase (AMPK) remains a central focus of research for the treatment of insulin resistance. The purpose of the current study was to determine the role of AMPKα2 activity in the regulation of glucose uptake and FA metabolism in insulin‐resistant skeletal muscle. Male C57BL/6 mice were divided into control diet (CD) or high fat (60%) diet (HFD) fed groups for six weeks and were either wild type (WT) or possessed an AMPKα2 dominant negative transgene (DN). After 6 weeks, hindlimbs of CD (n = 10) and HFD (n = 10...
Source: Experimental Physiology - February 3, 2012 Category: Physiology Authors: Marcia J. AbbottSilvana ConstantinescuLorraine P. Turcotte Source Type: research
Regular use of vitamin and mineral supplements could reduce the risk of colon cancerEmail this article to a colleague.
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(Canadian Science Publishing (NRC Research Press)) Could the use of vitamin and mineral supplements in a regular diet help to reduce the risk of colon cancer and protect against carcinogens? A study published in the Canadian Journal of Physiology and Pharmacology found that rats given regular multivitamin and mineral supplements showed a significantly lower risk of developing colon cancer when they were exposed to carcinogens. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 3, 2012 Category: Biology Source Type: news
AIBS names emerging public policy leadersEmail this article to a colleague.
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(American Institute of Biological Sciences) The American Institute of Biological Sciences has selected two graduate students to receive the 2012 AIBS Emerging Public Policy Leadership Award. Lida Beninson is a Ph.D. candidate in Integrative Physiology at the University of Colorado Boulder. Andrew Reinmann is a Ph.D. candidate in Biology at Boston University. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 3, 2012 Category: Global & Universal Source Type: news
Hypoxia-Inducible Factors in Physiology and MedicineEmail this article to a colleague.
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Gregg L. Semenza. Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional acti.... (Source: Cell)
Source: Cell - February 2, 2012 Category: Cytology Source Type: research
Regulation of Cell Physiology and Pathology by Protein S-Glutathionylation: Lessons Learned from the Cardiovascular SystemEmail this article to a colleague.
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Antioxidants & Redox Signaling Mar 2012, Vol. 16, No. 6: 524-542. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - February 2, 2012 Category: Research Tags: article Source Type: research
Impaired superficial femoral artery vasodilation and leg blood flow in young obese women following an oral glucose tolerance testEmail this article to a colleague.
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Applied Physiology, Nutrition, and Metabolism, Volume 37, Issue 1, Page 176-183, February 2012. (Source: Applied Physiology, Nutrition, and Metabolism)
Source: Applied Physiology, Nutrition, and Metabolism - February 2, 2012 Category: Physiology Tags: article Source Type: research
Combined effects of aerobic exercise and high-carbohydrate meal on plasma acylated ghrelin and levels of hungerEmail this article to a colleague.
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Applied Physiology, Nutrition, and Metabolism, Volume 37, Issue 1, Page 184-192, February 2012. (Source: Applied Physiology, Nutrition, and Metabolism)
Source: Applied Physiology, Nutrition, and Metabolism - February 2, 2012 Category: Physiology Tags: article Source Type: research
Type 1 diabetes impairs vitamin B6 metabolism at an early stage of women’s adulthoodEmail this article to a colleague.
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Applied Physiology, Nutrition, and Metabolism, Volume 37, Issue 1, Page 167-175, February 2012. (Source: Applied Physiology, Nutrition, and Metabolism)
Source: Applied Physiology, Nutrition, and Metabolism - February 2, 2012 Category: Physiology Tags: article Source Type: research
Validation of a new mixing chamber system for breath-by-breath indirect calorimetryEmail this article to a colleague.
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Applied Physiology, Nutrition, and Metabolism, Volume 37, Issue 1, Page 157-166, February 2012. (Source: Applied Physiology, Nutrition, and Metabolism)
Source: Applied Physiology, Nutrition, and Metabolism - February 2, 2012 Category: Physiology Tags: article Source Type: research
Book reviewsEmail this article to a colleague.
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Applied Physiology, Nutrition, and Metabolism, Volume 37, Issue 1, Page 197-198, February 2012. (Source: Applied Physiology, Nutrition, and Metabolism)
Source: Applied Physiology, Nutrition, and Metabolism - February 2, 2012 Category: Physiology Tags: book review Source Type: research
Grey matter volume alterations in CADASIL: a voxel-based morphometry studyEmail this article to a colleague.
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Abstract CADASIL is a hereditary disease characterized by cerebral subcortical microangiopathy leading to early onset cerebral strokes
and progressive severe cognitive impairment. Until now, only few studies have investigated the extent and localization of
grey matter (GM) involvement. The purpose of our study was to evaluate GM volume alterations in CADASIL patients compared
to healthy subjects. We also looked for correlations between global and regional white matter (WM) lesion load and GM volume
alterations. 14 genetically proved CADASIL patients and 12 healthy subjects were enrolled in our study. Brain M...
Source: The Journal of Headache and Pain - February 2, 2012 Category: Neurology Tags: The Journal of Headache and Pain Source Type: research
The effect of acute exercise with increasing workloads on inactive muscle blood flow and its heterogeneity in humansEmail this article to a colleague.
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In conclusion, while mean whole thigh muscle blood flow of the resting leg remains at resting level during one leg
exercise of the contralateral leg, redistribution of blood flow between muscle parts occurs within the thigh. Based on previous
studies, nervous constraints most probably act to cause this blood flow distribution.
Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00421-012-2329-5Authors
Ilkka Heinonen, Turku PET Centre, University of Turku and Turku University Hospital, PO Box 52, 20521 Turku, FinlandDirk J. Duncker, Division of Experimental Cardiology, Thoraxcenter, Erasmus M...
Source: European Journal of Applied Physiology - February 2, 2012 Category: Physiology Tags: European Journal of Applied Physiology Source Type: research
The determinants of performance in master swimmers: an analysis of master world recordsEmail this article to a colleague.
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Abstract Human performances in sports decline with age in all competitions/disciplines. Since the effects of age are often compounded
by disuse, the study of master athletes provides the opportunity to investigate the effects of age per se on the metabolic/biomechanical
determinants of performance. For all master age groups, swimming styles and distances, we calculated the metabolic power required
to cover the distance (d) in the best performance time as:
E \textmaxR¢ = C ×d/\textBTP = C ×vmax ,
where C is the energy cost of swimming in young elite swimmers, v
max = d/BTP...
Source: European Journal of Applied Physiology - February 2, 2012 Category: Physiology Tags: European Journal of Applied Physiology Source Type: research
Vibration detection and discrimination in the masked birch caterpillar (Drepana arcuata)Email this article to a colleague.
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Abstract Leaf-borne vibrations are potentially important to caterpillars for communication and risk assessment. Yet, little is known
about the vibratory environment of caterpillars, or how they detect and discriminate between vibrations from relevant and
non-relevant sources. We measured the vibratory ‘landscape’ of the territorial masked birch caterpillar Drepana arcuata (Drepanidae), and assessed its ability to detect and respond to vibrations generated by conspecific and predatory intruders,
wind and rain. Residents of leaf shelters were shown to respond to low amplitude vibrations generated by a crawl...
Source: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology - February 2, 2012 Category: Physiology Tags: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology Source Type: research
“From Bench to Practice”, ESC Congress set for Munich this summerEmail this article to a colleague.
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In response to feedback from delegates, this year’s congress will kick off on Saturday with a fuller day of scientific sessions. The grand finale on Wednesday will be a two-hour highlight session in which world leading experts summarise all the new and exciting developments in basic, clinical and population sciences presented at the congress. Read more about this year's event....
Topics:
Acute Coronary Syndromes (ACS), Arrhythmias, Atrial Fibrillation, Basic Science, Cardiac Tumours, Cardiovascular Disease Prevention - Risk Assessment and Management, Cardiovascular Nursing, Cardi...
Source: European Society of Cardiology - February 2, 2012 Category: Cardiology Source Type: news
Save on EuroPRevent registration until 6 FebruaryEmail this article to a colleague.
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EuroPRevent is the ideal occasion for clinicians, general practitioners, cardiologists in training, nurses and allied professionals to connect, network and discuss the latest topics in preventive cardiology.
Don't miss this opportunity - Deadline is Monday 6 February
Topics:
Cardiovascular Disease Prevention - Risk Assessment and Management, Rehabilitation and Exercise Physiology (Source: European Society of Cardiology)
Source: European Society of Cardiology - February 2, 2012 Category: Cardiology Source Type: news
Pericardial DiseasesEmail this article to a colleague.
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This article presents the anatomy and physiology of pericardial disease and the clinical approach for diagnosis and treatment. (Source: Current Problems in Cardiology)
Source: Current Problems in Cardiology - February 2, 2012 Category: Cardiology Authors: David M. Dudzinski, Gary S. Mak, Judy W. Hung Source Type: research
CCTS Asks Researchers to Take Survey on Human Tissue ProceduresEmail this article to a colleague.
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The University of Kentucky Center for Clinical and Translational Science (CCTS) is reaching out to researchers on campus to ask them to take a quick survey about access to human tissue samples. The survey is designed for any member of the university community who participates in biomedical research. (Source: UK College of Medicine News)
Source: UK College of Medicine News - February 2, 2012 Category: Universities & Medical Training Tags: 7H000 research physiology Center for Muscle Biology Pathology Source Type: news
