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This page shows you the most recent publications within this specialty of the MedWorm directory.

Transcranial Cortical Stimulation in the Treatment of Obsessive-Compulsive Disorders: Efficacy Studies
Abstract Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation methods that became widely used as therapeutic tools during the past two decades especially in cases of depression and schizophrenia. Low frequency rTMS and cathodal effect of tDCS inhibits cortical functioning while high frequency and anodal effect of tDCS have the opposite effect. Prolonged and repetitive application of either methods leads to changes in excitability of the human cortex that outlast the period of stimulation. Both rTMS and tDCS induce functional chan...
Source: Current Psychiatry Reports - March 31, 2015 Category: Psychiatry Source Type: research

Intranasal oxytocin administration prior to exposure therapy for arachnophobia impedes treatment response
ConclusionsThese results suggest that OT administration effects on extinction may vary depending on conditions and population. (Source: Depression and Anxiety)
Source: Depression and Anxiety - March 31, 2015 Category: Psychiatry Authors: Dean T. Acheson, David Feifel, Mary Kamenski, Rebecca Mckinney, Victoria B. Risbrough Tags: Research Article Source Type: research

Haemodynamic and electrophysiological markers of pragmatic language comprehension in schizophrenia
The World Journal of Biological Psychiatry, Ahead of Print. (Source: World Journal of Biological Psychiatry)
Source: World Journal of Biological Psychiatry - March 31, 2015 Category: Psychiatry Tags: article Source Type: research

Bilateral acute endophthalmitis associated with munchausen syndrome
Conclusion: Patients with Munchausen syndrome often injure themselves as a method of drawing attention, sympathy, or reassurance. Although ocular injuries due to psychiatric disease are known to occur, intraocular injection as a mode of self-injury is extremely rare. A high index of suspicion must be maintained when the reported history and clinical course are inconsistent. (Source: Retinal Cases and Brief Reports)
Source: Retinal Cases and Brief Reports - March 31, 2015 Category: Opthalmology Tags: Case Report Source Type: research

Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa
hork, B D Hammock & W Kaye (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: P B ShihJ YangC MorisseauJ B GermanA A Scott-Van ZeelandA M ArmandoO QuehenbergerA W BergenP MagistrettiW BerrettiniK A HalmiN SchorkB D HammockW Kaye Source Type: research

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy
en Buuse (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: M NotarasR HillM van den Buuse Source Type: research

Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome
Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome Molecular Psychiatry advance online publication, March 31 2015. doi:10.1038/mp.2015.29 Authors: M Hornig, G Gottschalk, D L Peterson, K K Knox, A F Schultz, M L Eddy, X Che & W I Lipkin (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: M HornigG GottschalkD L PetersonK K KnoxA F SchultzM L EddyX CheW I Lipkin Source Type: research

Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
Brennand (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: J KocerhaY DwivediK J Brennand Source Type: research

Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments
p; T C Südhof (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: J LiangW XuY-T HsuA X YeeL ChenT C Südhof Source Type: research

Whole-genome association analysis of treatment response in obsessive-compulsive disorder
ge, M Mattheisen, N C McLaughlin, K-Y Liang, E L Nurmi, K D Askland, G Nestadt & Y Y Shugart (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: H QinJ F SamuelsY WangY ZhuM A GradosM A RiddleB D GreenbergJ A KnowlesA J FyerJ T McCrackenD L MurphyS A RasmussenB A CullenJ PiacentiniD GellerS E StewartD PaulsO J BienvenuF S GoesB MaherA E PulverD ValleC LangeM MattheisenN C McLaughlinK-Y LiangE L Nu Source Type: research

Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study
ochunov & L E Hong (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: L M RowlandB W KrauseS A WijtenburgR P McMahonJ ChiappelliK L NugentS J NisongerS A KorenicP KochunovL E Hong Source Type: research

Kraepelin revisited: schizophrenia from degeneration to failed regeneration
Honer & A Schmitt (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: P FalkaiM J RossnerT G SchulzeA HasanM M BrzózkaB MalchowW G HonerA Schmitt Source Type: research

Telling true from false: cannabis users show increased susceptibility to false memories
p; A Rodríguez-Fornells (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: J RibaM ValleF SampedroA Rodríguez-PujadasS Martínez-HortaJ KulisevskyA Rodríguez-Fornells Source Type: research

Durable fear memories require PSD-95
N Singewald, W Xu & A Holmes (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - March 31, 2015 Category: Psychiatry Authors: P J FitzgeraldC R PinardM C CampM FeyderA SahH C BergstromC GraybealY LiuO M SchlüterS G N GrantN SingewaldW XuA Holmes Source Type: research

The efficacy of deep repetitive transcranial magnetic stimulation over the medial prefrontal cortex in obsessive compulsive disorder: results from an open‐label study
ConclusionsOur results suggest the use of low frequency deep rTMS as a promising and robust intervention in OCD symptom reduction. However, this study is limited by its open‐label nature and its lack of a control group, so further randomized clinical trials are needed to confirm these results. (Source: Depression and Anxiety)
Source: Depression and Anxiety - March 31, 2015 Category: Psychiatry Authors: Mandana Modirrousta, Ehsan Shams, Cara Katz, Behzad Mansouri, Zahra Moussavi, Jitender Sareen, Murray Enns Tags: Research Article Source Type: research

Detection of anxiety disorders in primary care: a meta‐analysis of assisted and unassisted diagnoses
ConclusionsThe use of diagnostic tools might improve detection of anxiety disorders in “primary care.” (Source: Depression and Anxiety)
Source: Depression and Anxiety - March 31, 2015 Category: Psychiatry Authors: Elena Olariu, Carlos G. Forero, Jose Ignacio Castro‐Rodriguez, Maria Teresa Rodrigo‐Calvo, Pilar Álvarez, Luis M. Martín‐López, Alicia Sánchez‐Toto, Núria D. Adroher, Maria J. Blasco‐Cubedo, Gemma Vilagut, Miquel A. Fullana, Jordi Alonso Tags: Review Source Type: research

Reward learning in pediatric depression and anxiety: preliminary findings in a high‐risk sample
ConclusionsOur results are a first demonstration that reward learning deficits are present among youth with disorders known to blunt anhedonic function and that these deficits have some degree of diagnostic specificity. We advocate for future studies to replicate and extend these preliminary findings. (Source: Depression and Anxiety)
Source: Depression and Anxiety - March 31, 2015 Category: Psychiatry Authors: Bethany H. Morris, Lauren M. Bylsma, Ilya Yaroslavsky, Maria Kovacs, Jonathan Rottenberg Tags: Research Article Source Type: research

Vagus nerve stimulation for treatment-resistant mood disorders: a long-term naturalistic study
Conclusions: Our case series showed that long-term VNS may be effective in reducing severity of depression in a small but significant minority of patients, although two patients had stimulation terminated because of adverse effects and/or refusal to continue the study. (Source: BMC Psychiatry)
Source: BMC Psychiatry - March 31, 2015 Category: Psychiatry Authors: Umberto AlbertGiuseppe MainaAndrea AgugliaAlberto VitalucciFilippo BogettoChiara FrondaAlessandro DucatiMichele Lanotte Source Type: research

Cost-effectiveness of active monitoring versus antidepressants for major depression in primary health care: a 12-month non-randomized controlled trial (INFAP study)
DiscussionGiven the high burden and costs generated by depressive disorder, it is important that general practitioners treat major depression efficiently. Recent evidence has suggested that antidepressants have low benefits for patients with mild to moderate major depression. For such cases of depression, active monitoring exists as a treatment option, but it is not without difficulties for implementation and its effectiveness and efficiency have not been demonstrated conclusively. The results of the study will provide information on which is the most efficient approach to treat patients with mild to moderate major depress...
Source: BMC Psychiatry - March 31, 2015 Category: Psychiatry Authors: Maria Rubio-ValeraImma BeneitezMaría Peñarrubia-MaríaJuan LucianoJuan MendivePaul McCroneMartin KnappRamon Sabés-FigueraKatarzyna KocyanJavier García-CampayoAntoni Serrano-Blanco Source Type: research

Childhood Maltreatment, Depression, and Suicidal Ideation: Critical Importance of Parental and Peer Emotional Abuse during Developmental Sensitive Periods in Males and Females
Alaptagin Khan, Hannah Claire McCormack, Elizabeth Anna Bolger, Cynthia McGreenery, Gordana Vitaliano, Ann Polcari and Martin Hersch Teicher (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - March 30, 2015 Category: Psychiatry Source Type: research

Spreading Pathologies Precede Cognitive Decline in Alzheimer’s Disease
The precuneus, which forms the medial wall of the parietal cortex (Brodmann area 7), has been identified as the control center of the default mode network, a system responsible for what has been called “passive cognition”—in other words, consciousness in the resting brain (i.e., when it is not being receptive to exogenous stimuli). Cholinergic input to the precuneus is via projections from basal forebrain neurons, a system that is dependent on the neurotrophin nerve growth factor (NGF) (1). Choline acetyltransferase (ChAT) enzyme activity in the precuneus is reduced in patients with clinical Alzheimer’s disease (AD...
Source: Biological Psychiatry - March 30, 2015 Category: Psychiatry Authors: David R. Howlett, Johannes Attems, Paul T. Francis Tags: Commentary Source Type: research

Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - March 30, 2015 Category: Psychiatry Source Type: research

A brief summary of the articles appearing in this issue of .
In this review, McConathy and Sheline (pages 685–692) focus on neuroimaging biomarkers of the earliest stage of Alzheimer’s disease (AD), namely preclinical AD, including magnetic resonance imaging measures of volume and cortical thickness as well as positron emission tomography. They address how such biomarkers can be used to distinguish AD from other dementias, which is important due to the lack of clinical symptoms at this stage of the disease. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 30, 2015 Category: Psychiatry Tags: In This Issue Source Type: research

Reducing β-Amyloid by Inhibition of : How Low Should You Go?
The product of the familial Alzheimer’s disease (AD) gene amyloid beta (A4) precursor protein (APP) can be processed in two major ways, one amyloidogenic and the other nonamyloidogenic. Beta-site APP-cleaving enzyme 1 (BACE1) is responsible for the initial cleavage in the amyloidogenic pathway and is necessary for the production of β-amyloid (Aβ). Increased levels of Aβ in the brains of patients with AD are widely held to be responsible for the familial and the sporadic forms of AD. In the brain, Aβ can form aggregates that accumulate as deposits, the senile plaques that are a hallmark of AD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 30, 2015 Category: Psychiatry Authors: Richard Killick, John Hardy, J. Paul Simons Tags: Commentary Source Type: research

Alzheimer’s Disease: Distinct Stages in Neurogenic Decline?
The functional connection of Alzheimer’s disease (AD) with adult neurogenesis remains a lingering question in the field. A deep understanding of the detrimental effects of AD pathology on neurogenesis and a potentially compensatory role for newborn neurons in dementia may lead to a more complete picture of AD pathology and new therapeutic avenues. The few human autopsy studies that have been conducted are as inconsistent as the results from mouse models, including diametrically opposed reports in some cases. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 30, 2015 Category: Psychiatry Authors: David H. Adamowicz, Jerome Mertens, Fred H. Gage Tags: Commentary Source Type: research

Guide for Authors
(Source: Biological Psychiatry)
Source: Biological Psychiatry - March 30, 2015 Category: Psychiatry Source Type: research

Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - March 30, 2015 Category: Psychiatry Source Type: research