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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Take a Holiday from Holiday Anxiety
Holidays are often stressful, and can contribute to worse mood and higher anxiety. Here are 3 ways to focus on being well and staying well this season. (Source: About.com Generalized Anxiety)
Source: About.com Generalized Anxiety - November 27, 2014 Category: Psychiatry Tags: health Source Type: news

The prevalence of post-traumatic stress disorder in patients with burn injuries, and their quality of life
International Journal of Psychiatry in Clinical Practice, Ahead of Print. (Source: International Journal of Psychiatry in Clinical Practice)
Source: International Journal of Psychiatry in Clinical Practice - November 24, 2014 Category: Psychiatry Tags: article Source Type: research

The Rate and Shape of Change in Binge Eating Episodes and Weight: An Effectiveness Trial of Emotionally Focused Group Therapy for Binge-Eating Disorder.
CONCLUSION: Cubic modelling of change supported a three-stage model of EFGT and CT, and the cubic trajectory was associated with better outcomes at follow-up. The addition of dietary counselling to EFGT resulted in earlier response to treatment in terms of BE episodes and weight among those in the CT condition. KEY PRACTITIONER MESSAGE: Decline in binge eating (BE) episodes is related to decline in weight, and this relationship was greater towards the end of treatment.Emotionally focused group therapy plus dietary counselling that targets both affect regulation and nutritional problems resulted in faster rate of respon...
Source: Clinical Psychology and Psychotherapy - November 24, 2014 Category: Psychiatry Tags: Clin Psychol Psychother Source Type: research

Effects of S100B on Serotonergic Plasticity and Neuroinflammation in the Hippocampus in Down Syndrome and Alzheimer's Disease: Studies in an S100B Overexpressing Mouse Model.
Authors: Shapiro LA, Bialowas-McGoey LA, Whitaker-Azmitia PM Abstract S100B promotes development and maturation in the mammalian brain. However, prolonged or extensive exposure can lead to neurodegeneration. Two important functions of S100B in this regard, are its role in the development and plasticity of the serotonergic neurotransmitter system, and its role in the cascade of glial changes associated with neuroinflammation. Both of these processes are therefore accelerated towards degeneration in disease processes wherein S100B is increased, notably, Alzheimer's disease (AD) and Down syndrome (DS). In order to stu...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats.
Authors: Agrawal SS, Gullaiya S, Dubey V, Singh V, Kumar A, Nagar A, Tiwari P Abstract Study was undertaken to evaluate the neurodegenerative defending potential of curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) on 6-hydroxydopamine-(6-OHDA) induced Parkinsonism model in rats. Curcuminoids were administered (60 mg/kg, body weight, per oral) for three weeks followed by unilateral injection of 6-OHDA on 22nd day (10 μg/2 μL) into the right striatum leading to extensive loss of dopaminergic cells. The behavioral observations, biochemical markers, quantification of dopamine (DA), DOPAC...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Exploring the cognitive features in children with autism spectrum disorder, their co‐twins, and typically developing children within a population‐based sample
ConclusionsMultiple cognitive atypicalities appear to be a characteristic, but not universal feature, of ASD. Further work is needed to investigate whether specific cognitive atypicalities, either alone or together, are related to specific behaviours characteristic of ASD. (Source: Journal of Child Psychology and Psychiatry)
Source: Journal of Child Psychology and Psychiatry - November 24, 2014 Category: Psychiatry Authors: Victoria E. A. Brunsdon, Emma Colvert, Catherine Ames, Tracy Garnett, Nicola Gillan, Victoria Hallett, Stephanie Lietz, Emma Woodhouse, Patrick Bolton, Francesca Happé Tags: Original Article Source Type: research

Possible treatment concepts for the levodopa-related hyperhomocysteinemia.
Authors: Müller T Abstract The saga of harmful levodopa (LD) in the treatment of Parkinson's disease (PD) resulted from outcomes of animal-and cell culture studies and the clinical observation of motor complication related to the short half life of LD. Further aspects of LD long term application, the LD associated homocysteine increase and its emerging consequences on progression, and onset of neuropsychiatric symptoms and of vascular disease are only partially considered. Therapeutic approaches for this LD-mediated neurotoxic homocysteine increase are vitamin supplementation or LD application with an inhibitor of...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Forebrain ischemia triggers GABAergic system degeneration in substantia nigra at chronic stages in rats.
This study revealed delayed neurodegeneration in the substantia nigra 8 weeks after 12.5 minutes of global ischemia in rat brain. Following neuronal loss of 30-40% in central and dorsolateral striatum at day 3, neuronal damage in the substantia nigra (SN) was assessed at 4-8 weeks using immunohistochemistry for glutamate decarboxylase 67 (GAD67), vesicular GABA transporter (VGAT), and calretinin (CR). At day 56, the optical density of GAD67-, but not VGAT-, immunoreactivity in substantia nigra pars reticulata (SNR)-significantly decreased. CR-neurons concentrated in substantia nigra pars compacta (SNC) were reduced by 27% ...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Serotonin transporter clustering in blood lymphocytes of reeler mice.
Authors: Rivera-Baltanas T, Romay-Tallon R, Dopeso-Reyes IG, Caruncho HJ Abstract Serotonin transporter clustering is an important feature for regulation of this transporter activity. We used immunocytochemistry to analyze alterations in serotonin transporter clustering in blood lymphocytes of reeler mice. Serotonin transporter immunolabelling is observed mostly as a patchy staining in lymphocytes membranes. Comparison of the number and size of serotonin transporter clusters in wild-type mice, heterozygous reeler mice, and homozygous reeler mice showed an increase in the number and size of clusters in heterozygous ...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Mental health among a nationally representative sample of United States Military Reserve Component Personnel
Conclusions The study reveals notable differences in PTSD and depression prevalence by service branch that may be attributable to a combination of factors including greater lifetime trauma exposures and differing operational military experiences. Our findings suggest that service branch and organizational differences are related to key protective and/or risk factors, which may prove useful in guiding prevention and treatment efforts among reservists. (Source: Social Psychiatry and Psychiatric Epidemiology)
Source: Social Psychiatry and Psychiatric Epidemiology - November 24, 2014 Category: Psychiatry Source Type: research

Treatment concerns for anaesthetists with substance abuse disorder.
PMID: 25414456 [PubMed - in process] (Source: Australasian Psychiatry)
Source: Australasian Psychiatry - November 24, 2014 Category: Psychiatry Authors: Fry R, Prager S, Shrivastava P Tags: Australas Psychiatry Source Type: research

Blood-brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy.
This study aimed to investigate the frequency, extent, and functional correlates of BBB disruption in epileptic patients following mild traumatic brain injury (TBI). Thirty-seven TBI patients were included in this study, 19 of whom suffered from PTE. All underwent electroencephalographic (EEG) recordings and brain magnetic resonance imaging (bMRI). bMRIs were evaluated for BBB disruption using novel quantitative techniques. Cortical dysfunction was localized using standardized low-resolution brain electromagnetic tomography (sLORETA). TBI patients displayed significant EEG slowing compared to controls with no significant d...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Day hospital Mentalization-based treatment versus intensive outpatient Mentalization-based treatment for patients with severe borderline personality disorder: protocol of a multicentre randomized clinical trial
This study focuses on the efficacy and cost-effectiveness of Mentalization-Based Treatment (MBT), a manualized treatment for patients with BPD. Studies to date have either investigated MBT in a day hospitalization setting (MBT-DH) or MBT offered in an intensive outpatient setting (MBT-IOP). No trial has compared the efficacy and cost-effectiveness of these MBT programmes. As both interventions differ considerably in terms of intensity of treatment, and thus potentially in terms of efficacy and cost-effectiveness, there is a need for comparative trials. This study therefore sets out to investigate the efficacy and cost-effe...
Source: BMC Psychiatry - November 18, 2014 Category: Psychiatry Authors: Elisabeth LaurenssenMaaike SmitsDawn BalesDine FeenstraHester EerenMarc NoomMaartje KösterZwaan LucasReinier TimmanJack DekkerPatrick LuytenJan BusschbachRoel Verheul Source Type: research

Corrigendum to “Oxytocin administration enhances controlled social cognition in patients with schizophrenia” [Psychoneuroendocrinology 47 (2014) 116–125]
We acknowledge that this work was supported by Career Development Award # CX000758 from the United States Department of Veterans Affairs, Office of Research and Development, Clinical Science Research and Development program. (Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - November 23, 2014 Category: Psychiatry Authors: J.D. Woolley, B. Chuang, O. Lam, W. Lai, A. O’Donovan, K.P. Rankin, D.H. Mathalon, S. Vinogradov Tags: Corrigendum Source Type: research

A brief summary of the articles appearing in this issue of
Significant progress has been made in the effort to dissect the molecular changes associated with administration of addictive drugs in animal models. Addictive drugs activate the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the striatum, which control multiple substrates, some of which are critically involved in cocaine-mediated molecular and behavioral adaptations. Here, Pascoli et al. (pages 917–926) review recent knowledge on the implication of ERK in long-lasting neuronal adaptations underlying behavioral alterations induced by psychostimulants. (Source: Biological Psychiatry)
Source: Biological Psychiatry - November 20, 2014 Category: Psychiatry Tags: In This Issue Source Type: research

Interactive effects of N-acetylcysteine and antidepressants
Publication date: 1 July 2013 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 44 Author(s): Luciane Costa-Campos , Ana P. Herrmann , Luísa K. Pilz , Marcus Michels , Guilherme Noetzold , Elaine Elisabetsky N-acetylcysteine (NAC), a glutathione precursor and glutamate modulator, has been shown to possess various clinically relevant psychopharmacological properties. Considering the role of glutamate and oxidative stress in depressive states, the poor effectiveness of antidepressant drugs (ADs) and the benefits of drug combination for treating depression, the aim of this study was to explore t...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 21, 2014 Category: Psychiatry Source Type: research

Internet addiction is related to attention deficit but not hyperactivity in a sample of high school students
International Journal of Psychiatry in Clinical Practice, Ahead of Print. (Source: International Journal of Psychiatry in Clinical Practice)
Source: International Journal of Psychiatry in Clinical Practice - November 20, 2014 Category: Psychiatry Tags: article Source Type: research

Editorial Board
(Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - November 23, 2014 Category: Psychiatry Source Type: research

5-HT2A/C receptors mediate the antipsychotic-like effects of alstonine
This study presents additional evidence that 5-HT2A/C receptors are central to the antipsychotic-like effects of alstonine, consistently seen in mouse models relevant to the three dimensions of schizophrenia symptoms. Highlights ► Alstonine is a putative atypical antipsychotic. ► The participation of 5HT2A/C receptors on alstonine effects was examined. ► Mouse models of positive, negative and cognitive symptoms were used. ► Ritanserin abolished alstonine effects. ► 5HT2A/C receptors mediate alstonine antipsychotic-like effects. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 21, 2014 Category: Psychiatry Source Type: research

Verification of the utility of the social responsiveness scale for adults in non-clinical and clinical adult populations in Japan
Conclusion: This study provides additional supportive evidence that the Japanese version SRS-A can reliably and validly measure ASD symptoms in non-clinical and clinical adult populations, and thus can serve as a useful tool for ASD research as well as for secondary screening in Japanese adults. (Source: BMC Psychiatry)
Source: BMC Psychiatry - November 18, 2014 Category: Psychiatry Authors: Reiko TakeiJunko MatsuoHidetoshi TakahashiTokio UchiyamaHiroshi KunugiYoko Kamio Source Type: research