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Table of Contents
Abstract Study shows effect of medications in reducing risk of violent crime Lithium exposure during pregnancy linked with cardiovascular defects Quetiapine‐induced pancreatitis Melatonin attenuates metabolic effects of some antipsychotics Violence in America: Is psychopharmacology the answer? Ketamine infusion reduces symptom severity in PTSD Oxytocin enhances effectiveness of cognitive training in schizophrenia Alcohol use medications result in drinking reduction SAMe, escitalopram fail to separate from placebo in depression trial Data on self‐harm point to need for caution on antidepressants Baclofen effective as ad...
Source: The Brown University Psychopharmacology Update - July 24, 2014 Category: Psychiatry Source Type: research

Overlap between ADHD and Autism – Clinical and Genetic Evidence
(Source: Current Psychiatry Reviews)
Source: Current Psychiatry Reviews - July 24, 2014 Category: Psychiatry Authors: Gill, MichaelAnney, RichardMulligan, Aisling Tags: Articles Source Type: research

Population study of disease burden, management, and treatment of bipolar disorder in Sweden: a retrospective observational registry study
ConclusionsIn Sweden, the incidence and prevalence of diagnosed bipolar disorder have increased during the last 20 years. Compared to the general population, these patients had similar education levels, lower employment levels, less disposable income, more sick leave, and twice the mortality. A trend towards earlier diagnosis, more use of antidepressants, and less use of lithium was seen. (Source: Bipolar Disorders)
Source: Bipolar Disorders - July 24, 2014 Category: Psychiatry Authors: Andreas Carlborg, Lena Ferntoft, Marcus Thuresson, Johan Bodegard Tags: Original Article Source Type: research

The efficacy and tolerability of cariprazine in acute mania associated with bipolar I disorder: a phase II trial
ConclusionCariprazine demonstrated superior efficacy versus placebo and was generally well tolerated in patients experiencing acute manic or mixed episodes associated with bipolar I disorder. (Source: Bipolar Disorders)
Source: Bipolar Disorders - July 24, 2014 Category: Psychiatry Authors: Suresh Durgam, Anju Starace, Dayong Li, Raffaele Migliore, Adam Ruth, György Németh, István Laszlovszky Tags: Original Article Source Type: research

Table of Contents
Abstract Adding risperidone for children with ADHD, ODD/CD, and aggression results in limited improvement Off‐label antipsychotic use rising in Medicaid population with less complex problems Small‐scale study finds atypical antipsychotics do not cause metabolic problems in prepubertal children Pharmacogenetics to be NIH focus for next decade AAP urges caution in prescribing ADHD medications CDC survey finds slight increase in youth suicide attempts NAC effective for self‐injurious behavior in 4‐year‐old with ASD Indictment of FedEx Corporation for Illegally Distributing Prescription Drugs (Source: The Brown Unive...
Source: The Brown University Child and Adolescent Psychopharmacology Update - July 24, 2014 Category: Psychiatry Source Type: research

Meanings of manic episodes in patients with bipolar disorder in remission: a qualitative study
Conclusion The findings of this research contribute to a greater understanding of manic frames in BD that can assist in the reflections on the doctor-patient relationship, to develop strategies for adherence and the therapeutic and preventive measures of recurrent. Can assist the health team involved in monitoring these cases and also the researchers in investigation of the contribution of these meanings discussed here in the phenomena of adherence to treatment and a better prognosis. (Source: Jornal Brasileiro de Psiquiatria)
Source: Jornal Brasileiro de Psiquiatria - August 9, 2014 Category: Psychiatry Source Type: research

Neonatal jaundice and increased risk of attention‐deficit hyperactivity disorder: a population‐based cohort study
ConclusionNeonates with jaundice are at high risk for developing physician‐diagnosed ADHD during their growth period. A risk alert regarding neurologic consequences is urgently required after a neonatal jaundice diagnosis. Additional studies should be conducted to clarify the pathogenesis of these relationships. (Source: Journal of Child Psychology and Psychiatry)
Source: Journal of Child Psychology and Psychiatry - July 25, 2014 Category: Psychiatry Authors: Chang‐Ching Wei, Chun‐Hung Chang, Cheng‐Li Lin, Shih‐Ni Chang, Tsai‐Chung Li, Chia‐Hung Kao Tags: Original Article Source Type: research

Disturbed cortico-amygdalar functional connectivity as pathophysiological correlate of working memory deficits in bipolar affective disorder.
Authors: Stegmayer K, Usher J, Trost S, Henseler I, Tost H, Rietschel M, Falkai P, Gruber O Abstract Patients suffering from bipolar affective disorder show deficits in working memory functions. In a previous functional magnetic resonance imaging study, we observed an abnormal hyperactivity of the amygdala in bipolar patients during articulatory rehearsal in verbal working memory. In the present study, we investigated the dynamic neurofunctional interactions between the right amygdala and the brain systems that underlie verbal working memory in both bipolar patients and healthy controls. In total, 18 euthymic bipol...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 15, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Emotional perception and theory of mind in first episode psychosis: The role of obsessive-compulsive symptomatology
The aim of the present study was to investigate the effects of comorbid obsessive-compulsive symptoms on emotional perception and theory of mind (ToM) in patients with first-episode psychosis. Participants were 65 patients with non-affective first episode psychosis (FEP) and 47 healthy controls. The patient group was divided into two subgroups, those with (FEP+; n=38) and those without obsessive-compulsive symptomatology (FEP-; n=27). Emotion perception and ToM were assessed with the Perception of Social Inference Test. (Source: Psychiatry Research)
Source: Psychiatry Research - July 31, 2014 Category: Psychiatry Authors: Evangelos Ntouros, Vasilios P. Bozikas, Christina Andreou, Dimitris Kourbetis, Grigoris Lavrentiadis, George Garyfallos Source Type: research

Psychometric properties of assessment instruments for autism spectrum disorder: a systematic review of Brazilian studies
Conclusion Considering both the psychometric aspects and the copyright information, the screening instrument that currently appears to be best indicated for clinical and research use is the M-CHAT. It was also noticed that there are still no specific ASD diagnostic tools available for use in Brazil. This lack of diagnostic instruments consists in a critical situation for the improvement of clinical practice and the development of research in this area. Objetivo Revisar sistematicamente a literatura científica acerca das propriedades psicométricas de instrumentos internacionais para a avaliação do transtorno do espectro...
Source: Jornal Brasileiro de Psiquiatria - August 9, 2014 Category: Psychiatry Source Type: research

Striatal Development in Autism: Repetitive Behaviors and the Reward Circuitry
Autism spectrum disorder (ASD) is defined by two essential features—impaired social communication abilities, including deficits with social reciprocity, nonverbal communication, and establishing relationships, and the presence of restricted and repetitive behaviors and interests (RRBIs). Social deficits receive most of the attention both in science and in the popular media, but RRBIs are equally important in understanding autism. Although RRBIs are also seen in typically developing preschoolers as well as in other psychiatric disorders such as obsessive-compulsive disorder, their impairing and persisting character is a h...
Source: Biological Psychiatry - August 6, 2014 Category: Psychiatry Authors: Gregor Kohls, Benjamin E. Yerys, Robert T. Schultz Tags: Commentaries Source Type: research

Family caregivers? burden as a function of psychiatric patients diagnostics
Conclusion The differences found in this study pointed out the need for mental health services to plan specific interventions for each group of family caregivers. (Source: Jornal Brasileiro de Psiquiatria)
Source: Jornal Brasileiro de Psiquiatria - August 9, 2014 Category: Psychiatry Source Type: research

A brief summary of the articles appearing in this issue of
Chini et al. (pages 360–366) review the role of oxytocin in learning and memory. The authors suggest that oxytocin plays a role in cognitive and behavioral flexibility in animal models. These effects of oxytocin may be related to the ability of intranasal oxytocin to improve memory in patients with schizophrenia or posttraumatic stress disorder. They conclude that further studies of oxytocin’s therapeutic potential as an enhancer of learning and memory are warranted. (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 6, 2014 Category: Psychiatry Tags: In this Issue Source Type: research

Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta‐analysis of randomized controlled trials
ConclusionsMinocycline may improve the psychopathology of schizophrenia, especially the negative symptoms, and seems to be well tolerated. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 4, 2014 Category: Psychiatry Authors: Kazuto Oya, Taro Kishi, Nakao Iwata Tags: Research Article Source Type: research

Interneurons are necessary for coordinated activity during reversal learning in orbitofrontal cortex
Cerebral cortical GABAergic interneuron dysfunction is hypothesized to lead to cognitive deficits co-morbid with human neuropsychiatric disorders, including schizophrenia, autism and epilepsy. We have previously shown that mice that harbor mutations in the Plaur gene, which is associated with schizophrenia, have deficits in frontal cortical parvalbumin expressing interneurons. Plaur mice have impaired reversal learning, similar to deficits observed in patients with schizophrenia. (Source: Biological Psychiatry)
Source: Biological Psychiatry - August 1, 2014 Category: Psychiatry Authors: Gregory B. Bissonette, Geoffrey Schoenbaum, Matthew R. Roesch, Elizabeth M. Powell Source Type: research

The prevalence of pain in bipolar disorder: a systematic review and large‐scale meta‐analysis
ConclusionPeople with BD experience significantly increased levels of pain (particularly chronic pain and migraine). The assessment and treatment of pain should form an integral part of the management of BD. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - August 6, 2014 Category: Psychiatry Authors: B. Stubbs, L. Eggermont, A. J. Mitchell, M. De Hert, C. U. Correll, A. Soundy, S. Rosenbaum, D. Vancampfort Tags: Meta‐analysis Source Type: research

Affective prosody perception in symptomatically remitted patients with schizophrenia and bipolar disorder
Affect perception has frequently been shown to be impaired in patients suffering from schizophrenia or bipolar disorder (BD), but it remains unclear whether these impairments exist during symptomatic remission and whether the two disorders differ from each other in this regard. Most previous studies have investigated facial affect recognition, but not the ability to decode mental states from emotional tone of voice, i.e. affective prosody perception (APP). Accordingly, the present study directly compared APP in symptomatically remitted patients with schizophrenia or BD and healthy control subjects and investigated its rela...
Source: Schizophrenia Research - August 2, 2014 Category: Psychiatry Authors: Christine M. Hoertnagl, Nursen Yalcin-Siedentopf, Susanne Baumgartner, Falko Biedermann, Eberhard A. Deisenhammer, Armand Hausmann, Alexandra Kaufmann, Georg Kemmler, Moritz Mühlbacher, Anna-Sophia Rauch, Wolfgang W. Fleischhacker, Alex Hofer Source Type: research

Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia.
Authors: Krzyżanowska M, Steiner J, Brisch R, Mawrin C, Busse S, Braun K, Jankowski Z, Bernstein HG, Bogerts B, Gos T Abstract The central serotonergic system is implicated in the pathogenesis of schizophrenia, where the imbalance between dopamine, serotonin and glutamate plays a key pathophysiological role. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in schizophrenia patients. The study was carried out on paraffin-embedded brains from 17 (8 paranoid and 9 residual) schizophrenia patients and 28 matched controls without mental disorders. Th...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 8, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Helping Kids Succeed in School Despite OCD
Roger’s parents were nervous about the new school year. They remembered how Roger’s OCD had surfaced. His fear of possibly choking on lunch food had kept him away for weeks. This problem subsided, but Roger’s OCD had morphed into contamination fears. His parents were on edge and wanted to be ready. Parents whose children struggle with OCD wish for them to succeed academically, but when OCD gets in the way, they feel lost and helpless. They may not be sure if the school needs to be aware of the issue. Parents may fear that telling the teacher will single their child out and exacerbate the situation. Deciding when to t...
Source: Psych Central - August 17, 2014 Category: Psychiatry Authors: Annabella Hagen, LCSW, RPT-S Tags: Anxiety Caregivers Children and Teens Obsessive-Compulsive Disorder Parenting School Issues Students Achievement Anxious Children Childhood Ocd Contamination Obsession Mental Illness Stigma positive role model Schoolwork Source Type: news

Morning Break: Doc Brings Gun to Gunfight
(MedPage Today) -- Health news and commentary from around the Web, gathered by the MedPage Today staff. (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - July 25, 2014 Category: Psychiatry Source Type: news