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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Distinguishing Bipolar Disorder From Other Psychiatric Disorders in Children
Abstract Pediatric onset bipolar disorder (BD) is a challenging diagnosis with potentially debilitating outcomes. This review aims to critically evaluate recently published literature relevant to the diagnosis of BD in youth, emphasizing interesting and important new findings characterizing pediatric BD and reporting updates in the diagnostic and statistical manual relevant to this disorder in youth. Challenges regarding the diagnosis of BD will be discussed, in addition to important distinctions with other childhood disorders, including other bipolar spectrum disorders; major depressive disorder; dysthymia; disr...
Source: Current Psychiatry Reports - October 14, 2014 Category: Psychiatry Source Type: research

Risk of dementia in elderly patients with the use of proton pump inhibitors.
Authors: Haenisch B, von Holt K, Wiese B, Prokein J, Lange C, Ernst A, Brettschneider C, König HH, Werle J, Weyerer S, Luppa M, Riedel-Heller SG, Fuchs A, Pentzek M, Weeg D, Bickel H, Broich K, Jessen F, Maier W, Scherer M Abstract Drugs that modify the risk of dementia in the elderly are of potential interest for dementia prevention. Proton pump inhibitors (PPIs) are widely used to reduce gastric acid production, but information on the risk of dementia is lacking. We assessed association between the use of PPIs and the risk of dementia in elderly people. Data were derived from a longitudinal, multicenter cohort s...
Source: European Archives of Psychiatry and Clinical Neuroscience - October 25, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models
amp; J L Kennedy (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - September 30, 2014 Category: Psychiatry Authors: D S S LoboL AleksandrovaJ KnightD M CaseyN el-GuebalyJ N NobregaJ L Kennedy Source Type: research

Lithium and GSK-3β promoter gene variants influence cortical gray matter volumes in bipolar disorder
Conclusions Lithium and rs334558 influenced GM volumes in areas critical for the generation and control of affect, which have been widely implicated in the process of BD pathophysiology. In the light of the protective effects of lithium on white matter integrity, our results suggest that the clinical effects of lithium associate with a neurotrophic effect on the whole brain, probably mediated by GSK-3β inhibition. (Source: Psychopharmacology)
Source: Psychopharmacology - October 27, 2014 Category: Psychiatry Source Type: research

Table of Contents
Abstract Use of easily available biomarker could predict antidepressant response Antipsychotics show differing risks of mortality in community‐living elderly Oxcarbazepine‐induced serious skin reaction Long‐acting injectable aripiprazole comparable to oral medication in preventing relapse Adjunctive armodafinil shows promising results for bipolar depression Omega‐3 fatty acids fail to prevent relapse in schizophrenia Lower‐dose quetiapine safe and effective for personality disorder Varenicline aids smoking cessation in patients with bipolar disorder Older adults see heart benefits from antidepressant adherence Ap...
Source: The Brown University Psychopharmacology Update - October 27, 2014 Category: Psychiatry Source Type: research

Predisposing effects of neonatal visceral pain on abuse-related effects of morphine in adult male Sprague Dawley rats
Conclusions NVP-induced changes in brain opioid systems have persistent pharmacological consequences into adulthood and may increase sensitivity to abuse-related effects of opioids across development. (Source: Psychopharmacology)
Source: Psychopharmacology - October 25, 2014 Category: Psychiatry Source Type: research

Clozapine for treatment‐resistant bipolar disorder: a systematic review
ConclusionThe limited current evidence supports the concept that clozapine may be both an effective and a relatively safe medication for TRBD. (Source: Bipolar Disorders)
Source: Bipolar Disorders - October 27, 2014 Category: Psychiatry Authors: Xian‐Bin Li, Yi‐Lang Tang, Chuan‐Yue Wang, Jose Leon Tags: Review Article Source Type: research

Visual height intolerance and acrophobia: clinical characteristics and comorbidity patterns.
Authors: Kapfhammer HP, Huppert D, Grill E, Fitz W, Brandt T Abstract The purpose of this study was to estimate the general population lifetime and point prevalence of visual height intolerance and acrophobia, to define their clinical characteristics, and to determine their anxious and depressive comorbidities. A case-control study was conducted within a German population-based cross-sectional telephone survey. A representative sample of 2,012 individuals aged 14 and above was selected. Defined neurological conditions (migraine, Menière's disease, motion sickness), symptom pattern, age of first manifestation, prec...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 30, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Antipsychotic exposure prior to acute myocardial infarction in patients with serious mental illness
ConclusionThese findings are consistent with a short‐term risk effect of antipsychotic exposure on risk of AMI and identify potentially vulnerable groups. Further research is required to clarify underlying biological mechanisms. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - October 14, 2014 Category: Psychiatry Authors: S.‐I. Wu, K.‐L. Kao, S.‐C. Chen, J. J. M. Juang, C.‐J. Lin, C.‐K. Fang, C.‐S. Wu, M. Dewey, M. J. Prince, R. Stewart Tags: Original Article Source Type: research

Research Review: Birth by caesarean section and development of autism spectrum disorder and attention‐deficit/hyperactivity disorder: a systematic review and meta‐analysis
ConclusionsDelivery by CS is associated with a modest increased odds of ASD, and possibly ADHD, when compared to vaginal delivery. Although the effect may be due to residual confounding, the current and accelerating rate of CS implies that even a small increase in the odds of disorders, such as ASD or ADHD, may have a large impact on the society as a whole. This warrants further investigation. (Source: Journal of Child Psychology and Psychiatry)
Source: Journal of Child Psychology and Psychiatry - October 27, 2014 Category: Psychiatry Authors: Eileen A. Curran, Sinéad M. O'Neill, John F. Cryan, Louise C. Kenny, Timothy G. Dinan, Ali S. Khashan, Patricia M. Kearney Tags: Original Article Source Type: research

Sleep in infancy and childhood: implications for emotional and behavioral difficulties in adolescence and beyond
Purpose of review: Extensive scientific efforts have been made in an attempt to identify early markers of behavioral and emotional problems. In this context, sleep has received considerable research attention, as it appears to be closely linked to developmental psychopathology. The present review synthesizes some of the most recent findings regarding the concurrent and longitudinal associations between psychopathology and behavioral manifestations of sleep in childhood and adolescence. Recent findings: Recent evidence suggests that compromised sleep is associated with both internalizing and externalizing problems in childh...
Source: Current Opinion in Psychiatry - October 1, 2014 Category: Psychiatry Tags: SLEEP DISORDERS: Edited by Martica Hall Source Type: research

Differential regulation of observational fear and neural oscillations by serotonin and dopamine in the mouse anterior cingulate cortex
Conclusions The current results demonstrated that DA D2 receptors in the ACC are required for observational fear learning, whereas increased 5-HT levels disrupt observational fear and alter the regularity of ACC neural oscillations. (Source: Psychopharmacology)
Source: Psychopharmacology - October 25, 2014 Category: Psychiatry Source Type: research

Can low-dose propranolol induce a manic syndrome? Case report of an unexpected side effect.
Conclusion Although depression is a better-known side effect of b-adrenergic antagonists, clinicians should take mania as a rare side effect into consideration as well. PMID: 25287473 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - October 9, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects
Richards, P C Fletcher & E T Bullmore (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - September 30, 2014 Category: Psychiatry Authors: H ZiauddeenS R ChamberlainP J NathanA KochK MaltbyM BushW X TaoA NapolitanoA L SkeggsA C BrookeL ChekeN S ClaytonI Sadaf FarooqiS O'RahillyD WaterworthK SongL HoskingD B RichardsP C FletcherE T Bullmore Source Type: research

Bipolar I and II versus unipolar depression: Clinical differences and impulsivity/aggression traits.
CONCLUSION: Our findings comport with major previous findings on differences between bipolar and unipolar depression. As for trait characteristics, bipolar I and II depressed patients had more life-time impulsivity and aggression/hostility than unipolar patients. In addition, bipolar I and II patients also differed on these trait characteristics. PMID: 25280430 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - October 6, 2014 Category: Psychiatry Tags: Eur Psychiatry Source Type: research

Circadian rhythms and sleep in bipolar disorder: implications for pathophysiology and treatment
Purpose of review: Multiple lines of evidence support the conceptualization of bipolar disorder as a disorder of circadian rhythms. Considering bipolar disorder in the framework of circadian disturbances also helps understand the clinical phenomenology pointing toward a multisystemic involvement. Recent findings: Patients with bipolar disorder show altered rhythmicity in body temperature and melatonin rhythms, high day-to-day variability in activity and sleep timing, persistent disturbances of sleep or wake cycles, including disturbances of sleep continuity. The internal clocks are, indeed, responsible for regulating a var...
Source: Current Opinion in Psychiatry - October 1, 2014 Category: Psychiatry Tags: SLEEP DISORDERS: Edited by Martica Hall Source Type: research

The effect of quetiapine (Seroquel™) on conditioned place preference and elevated plus maze tests in rats when administered alone and in combination with (+)-amphetamine
We examined the hypothesis that quetiapine (10, 20 or 40 mg/kg) alone or co-administered with (+)-amphetamine (0.25, 0.5, 0.75 or 2.0 mg/kg) will affect reward and/or decrease anxiety in rats, as measured by conditioned place preference (CPP) and elevated plus maze (EPM) test, respectively. Results Quetiapine (20 mg/kg) produced greater open arm time and entries in the EPM test compared to 10 and 40 mg/kg, and quetiapine (10 mg/kg) significantly increased open arm entries and time when co-administered with (+)-amphetamine (0.5 mg/kg) compared to (+)-amphetamine (0.5 mg/kg)...
Source: Psychopharmacology - October 25, 2014 Category: Psychiatry Source Type: research

Cultural trends and eating disorders
This study highlights recent trends that reflect the changing landscape of culture and eating disorders: stabilization of the incidence of anorexia nervosa and possibly lower incidence rates of bulimia nervosa in Caucasian North American and Northern European groups; increasing rates of eating disorders in Asia; increasing rates of eating disorders in the Arab region; and increasing rates of binge eating and bulimia nervosa in Hispanic and Black American minority groups in North America. Summary: The changing face of eating disorders calls for a new conceptualization of culture in both the emergence and spread of eating di...
Source: Current Opinion in Psychiatry - October 1, 2014 Category: Psychiatry Tags: EATING DISORDERS: Edited by Hans W. Hoek Source Type: research

Preventive Strategies for Borderline Personality Disorder in Adolescents
Opinion statement Personality disorder has been shown to be common in adolescence and most notable for its continuity with and similarities to adult personality disorder. This has legitimized the diagnosis of personality disorder, particularly borderline personality disorder, in adolescence. The first wave of indicated prevention (targeting those showing early signs and symptoms) and early intervention (those with full-syndrome disorder) studies for borderline personality disorder in adolescence are notable for challenging fears about diagnosing and treating borderline personality disorder in young people, and dem...
Source: Current Treatment Options in Psychiatry - September 30, 2014 Category: Psychiatry Source Type: research

A further assessment of decision-making in anorexia nervosa.
CONCLUSION: These results tend to confirm an impaired decision making-process in people with AN and suggest that various cognitive processes such as inhibition to risk-taking or intolerance of uncertainty may underlie this condition Furthermore, these impairments seem unrelated to the potential co-occurent major depressive disorders. PMID: 25266757 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - October 1, 2014 Category: Psychiatry Tags: Eur Psychiatry Source Type: research