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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Naltrexone in Bipolar Disorder With Depression: A Double-Blind, Placebo-Controlled Study
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 6, 2014 Category: Psychiatry Tags: Letters to the Editors Source Type: research

Hemodynamic Profiles and Tolerability of Modafinil in the Treatment of Postural Tachycardia Syndrome: A Randomized, Placebo-Controlled Trial
ConclusionsModafinil did not significantly worsen standing HR or acute orthostatic symptoms in patients with POTS compared with the placebo group and improved upright blood pressure. Therefore, modafinil could be tested as a potential treatment for the cognitive impairment in POTS. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 6, 2014 Category: Psychiatry Tags: Brief Reports Source Type: research

Early and delayed treatment of bipolar disorder.
Authors: Nunes A, Hajek T, Alda M PMID: 25368364 [PubMed - in process] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - November 6, 2014 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Brain-derived neurotrophic factor (BDNF) and its precursor proBDNF as diagnostic biomarkers for major depressive disorder and bipolar disorder.
Authors: Hashimoto K PMID: 25362578 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - November 6, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

BDNF and proBDNF as biomarkers for bipolar disorder.
Authors: Hashimoto K PMID: 25368362 [PubMed - in process] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - November 6, 2014 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Effects of quetiapine on DNA methylation in neuroblastoma cells
Publication date: 2 January 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 56 Author(s): Hiroko Sugawara , Miki Bundo , Tatsuro Asai , Fumiko Sunaga , Junko Ueda , Jun Ishigooka , Kiyoto Kasai , Tadafumi Kato , Kazuya Iwamoto Epigenetic regulation may be involved in the pathophysiology of mental disorders, such as schizophrenia and bipolar disorder, and in the pharmacological action of drugs. Characterizing the epigenetic effects of drugs is an important step to optimal treatment. We performed comprehensive and gene-specific DNA methylation analyses of quetiapine using human neuroblast...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 6, 2014 Category: Psychiatry Source Type: research

Concomitant Use of Acetylcholine Esterase Inhibitors and Urinary Antispasmodics Among Finnish Community-Dwelling Persons With Alzheimer Disease
AbstractConcomitant use of acetylcholine esterase inhibitors (AChEIs) and anticholinergic drugs, such as urinary antispasmodics (UA), is generally considered as inappropriate because of their opposite pharmacological actions. However, prevalence and the duration or factors associated with concomitant use have not been previously studied among community-dwelling persons with Alzheimer disease (AD). The aim of this study was to examine the prevalence and duration of concomitant use of AChEIs and UAs among community-dwelling persons with AD and factors associated with concomitant use. Register-based data of the MEDALZ-2005 St...
Source: Journal of Clinical Psychopharmacology - November 6, 2014 Category: Psychiatry Tags: Original Contributions Source Type: research

Hoarding and eating pathology: The mediating role of emotion regulation
Hoarding disorder is characterized by persistent difficulty discarding possessions resulting in clutter that precludes one from using living areas for their intended purposes. The limited empirical work available has suggested a strong link between hoarding and various non-psychiatric conditions, including obesity. Despite these associations, no research has examined the link between hoarding and other forms of eating pathology including symptoms associated with binge eating. Moreover, little is known about mechanisms that may account for this relationship. (Source: Comprehensive Psychiatry)
Source: Comprehensive Psychiatry - November 5, 2014 Category: Psychiatry Authors: Amanda M. Raines, Joseph W. Boffa, Nicholas P. Allan, Nicole A. Short, Norman B. Schmidt Source Type: research

Effects of atomoxetine on attention and impulsivity in the five-choice serial reaction time task in rats with lesions of dorsal noradrenergic ascending bundle
Publication date: 2 January 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 56 Author(s): Yia-Ping Liu , Teng-Shun Huang , Che-Se Tung , Chen-Cheng Lin Atomoxetine, a noradrenaline reuptake inhibitor (NRI), which is a non-stimulating medicine that is used for the treatment of patients with attention deficit hyperactivity disorder (ADHD), has been found to be effective in reducing behavioral impulsivity in rodents, but its efficacy in a dorsal noradrenergic ascending bundle (DNAB)-lesioned condition has not been examined. The present study aimed to investigate the effects of DNAB lesions...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 6, 2014 Category: Psychiatry Source Type: research

EEG theta and beta power spectra in adolescents with ADHD versus adolescents with ASD + ADHD
Abstract Attention problems are common in youngsters with attention deficit hyperactivity disorder (ADHD) as well as in adolescents with combined autism spectrum disorder (ASD) and ADHD. However, it is unknown whether there is psychophysiological overlap and/or a difference in electroencephalogram (EEG) power spectra between ADHD and comorbid ASD and ADHD (ASD + ADHD), on and off stimulant medication. To explore potential differences and overlap, measures of theta and beta power in adolescents diagnosed with ADHD (n = 33) versus adolescents with combined ASD + ADHD (n = 20), categorized by stimulant medica...
Source: European Child and Adolescent Psychiatry - November 6, 2014 Category: Psychiatry Source Type: research

Recent advances in animal model experimentation in autism research.
CONCLUSION: In this review, we have presented recent advances in research based on animal models of autism, raising hope for understanding the disease biology for potential therapeutic intervention to improve the quality of life of autism individuals. PMID: 25371923 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 6, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Lamotrigine Reduces Affective Instability in Depressed Patients With Mixed Mood and Anxiety Disorders
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 6, 2014 Category: Psychiatry Tags: Letters to the Editors Source Type: research

Blood-brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy.
This study aimed to investigate the frequency, extent, and functional correlates of BBB disruption in epileptic patients following mild traumatic brain injury (TBI). Thirty-seven TBI patients were included in this study, 19 of whom suffered from PTE. All underwent electroencephalographic (EEG) recordings and brain magnetic resonance imaging (bMRI). bMRIs were evaluated for BBB disruption using novel quantitative techniques. Cortical dysfunction was localized using standardized low-resolution brain electromagnetic tomography (sLORETA). TBI patients displayed significant EEG slowing compared to controls with no significant d...
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Predictors of Response to Adjunctive Osmotic-Release Methylphenidate or Placebo in Patients With Major Depressive Disorder: Effects of Apathy/Anhedonia and Fatigue
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 6, 2014 Category: Psychiatry Tags: Letters to the Editors Source Type: research

Methylphenidate treatment causes oxidative stress and alters energetic metabolism in an animal model of attention-deficit hyperactivity disorder.
CONCLUSION: We observed that both acute and chronic use of methylphenidate hydrochloride (MPH) in adult spontaneously hypertensive rats (SHRs) was associated with increased oxidative stress and energetic metabolism alterations. These data also reinforce the importance of the SHR animal model in further studies regarding MPH. PMID: 24855887 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 27, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Prediction of methylphenidate treatment outcome in adults with attention-deficit/hyperactivity disorder (ADHD).
Authors: Retz W, Retz-Junginger P Abstract Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent mental disorder of childhood, which often persists in adulthood. Methylphenidate (MPH) is one of the most effective medications to treat ADHD, but also few adult patients show no sufficient response to this drug. In this paper, we give an overview regarding genetic, neuroimaging, clinical and other studies which have tried to reveal the reasons for non-response in adults with ADHD, based on a systematic literature search. Although MPH is a well-established treatment for adults with ADHD, research regardi...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 19, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Take a Holiday from Holiday Anxiety
Holidays are often stressful, and can contribute to worse mood and higher anxiety. Here are 3 ways to focus on being well and staying well this season. (Source: About.com Generalized Anxiety)
Source: About.com Generalized Anxiety - November 27, 2014 Category: Psychiatry Tags: health Source Type: news

Manualized Psychosocial Treatment Versus Standard Care in Opioid Maintenance Treatment: Results of a Randomized Clinical Trial and Follow-up Study
In this study, the hypothesis was that manualized psychosocial treatment was more effective than psychosocial treatment as usual. Moreover, the question was to find subgroups of patients who do not need or benefit from enhanced psychosocial treatment. The study design contains two manualized treatment groups and a control group of treatment as usual. There are two randomizations: (1) From the beginning, all patients were randomized to methadone or buprenorphine. (2) After having finished the control group treatment-as-usual, the subsequent patients were in addition randomly allocated to basic treatment or indicative treatm...
Source: Journal of Psychosocial Rehabilitation and Mental Health - November 23, 2014 Category: Psychiatry Source Type: research

Living with Binge Eating Disorder
If you have binge eating disorder, please know that you’re alone. Binge eating disorder (BED) is actually the most common eating disorder. It affects about 3.5 percent of women and 2 percent of men. You’re also not weak, wrong or crazy. BED “is not a reflection of who you are as a person,” said Karin Lawson, PsyD, a psychologist and clinical director of Embrace, the binge eating recovery program at Oliver-Pyatt Centers. Binge eating may serve many functions, according to Amy Pershing, LMSW, ACSW, the executive director of Pershing Turner Centers, an eating disorder recovery outpatient clinic in Ann Arbor, Mich., an...
Source: Psych Central - November 8, 2014 Category: Psychiatry Authors: Margarita Tartakovsky, M.S. Tags: Addictions Disorders Eating Disorders General Psychotherapy Self-Help Treatment Weight Loss Amy Pershing BED binge eating Binge Eating Disorder Compulsive Eating dieting emotional overeating health at every size Intuitive E Source Type: news

Smoking automaticity and tolerance moderate brain activation during explore–exploit behavior
The adaptive trade-off between exploration and exploitation is a key component in models of reinforcement learning. Over the past decade, these models have been applied to the study of reward-seeking behavior. Drugs of addiction induce reward-seeking behavior and modify its underlying neurophysiological processes. These neurophysiological changes may underlie a behavioral shift from a flexible, exploratory mode to a focused, exploitative mode, which precedes the development of inflexible, habitual drug use. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - October 21, 2014 Category: Psychiatry Authors: Merideth A. Addicott, John M. Pearson, Brett Froeliger, Michael L. Platt, F. Joseph McClernon Source Type: research