Bdf newlife
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Start Up Grants
Amount: £10K - £50K
Closing Date : 28 February 2009
Full Grants
Amount: £50K - £100K
Closing Date : 03 October 2008 (Source: RDFunding RSS feed)
Source: RDFunding RSS feed - July 6, 2008 Category: Research Source Type: funding
Drug treatment for marfan syndrome looks promising, johns hopkins researchers say
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A small study in 18 patients assessing the effectiveness of the drug losartan for treating Marfan syndrome in children has yielded encouraging results. Reporting in the June 26 issue of The New England Journal of Medicine, Johns Hopkins researchers showed that losartan-a compound used for years to treat high blood pressure-slowed the enlargement of the aorta, the most life-threatening defect associated with Marfan syndrome. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - July 4, 2008 Category: Research Source Type: news
Spiritual effects of hallucinogens persist, johns hopkins researchers report
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In a follow-up to research showing that psilocybin, a substance contained in "sacred mushrooms," produces substantial spiritual effects, a Johns Hopkins team reports that those beneficial effects appear to last more than a year. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - July 4, 2008 Category: Research Source Type: news
News: nature reviews molecular cell biology focus on lipids
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Lipids are important signaling molecules in cancer and inflammation, and in cardiovascular, neurodegenerative and metabolic diseases. A complex protein-lipid signaling network that comprises phosphoinositides, sphingolipids, steroids and other lipid-derived mediators has been uncovered in recent years. This FREE Focus contains research highlights, reviews that provide a snapshot of lipid biology and an accompanying 'Targeting lipid signaling in disease' poster. (Source: Nature Signaling Update)
Source: Nature Signaling Update - July 4, 2008 Category: Research Source Type: info
Research library: mapping and quantifying mammalian transcriptomes by rna-seq
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(Source: Nature Signaling Update)
Source: Nature Signaling Update - July 4, 2008 Category: Research Source Type: info
Research library: a gata6-wnt pathway required for epithelial stem cell development and airway regeneration
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(Source: Nature Signaling Update)
Source: Nature Signaling Update - July 4, 2008 Category: Research Source Type: info
Research library: rhoa and microtubule dynamics control cell-basement membrane interaction in emt during gastrulation
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(Source: Nature Signaling Update)
Source: Nature Signaling Update - July 4, 2008 Category: Research Source Type: info
Selected update: cancer genetics: looking at the big picture
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A new, large-scale mutagenesis screen in different mouse backgrounds identifies candidate oncogenes and tumor suppressors, and reveals the networks that link them together. (Source: Nature Signaling Update)
Source: Nature Signaling Update - July 4, 2008 Category: Research Source Type: info
Selected update: signalling: survival of the sweetest
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EGFR promotes cell survival in a kinase-independent fashion by preventing autophagy and maintaining a basal level of intracellular glucose, thus explaining the disappointing response rates to EGFR inhibitors in cancer patients. (Source: Nature Signaling Update)
Source: Nature Signaling Update - July 4, 2008 Category: Research Source Type: info
Selected update: protein degradation: catching ubiquitin
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The proteasome subunit Rpn13 is a high-affinity receptor for ubiquitin that recognizes its substrates through a novel ubiquitin-binding domain. (Source: Nature Signaling Update)
Source: Nature Signaling Update - July 4, 2008 Category: Research Source Type: info
Featured article: dna damage: atm and damage recovery are joined at the hipk
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The ATM and ATR kinases block Siah-1-mediated ubiquitination of HIPK2 during the DNA damage response. (Source: Nature Signaling Update)
Source: Nature Signaling Update - July 4, 2008 Category: Research Source Type: info
Possible relationship between chronic fatigue and postural tachycardia syndromes
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We describe five patients who satisfied the CFS criteria of the
Centres for Disease Control and Prevention. Upright tilt-table testing induced significant hypotension and increased heart
rate in all five patients, consistent with clinical and auronomic manifestation of postural tachycardia syndrome.
Content Type Journal ArticleCategory Research PapersDOI 10.1007/BF02556297Authors
F. De Lorenzo, Thrombosis Research Institute Emmanuel Kaye Building, Manresa Road London UKJ. Hargreaves, Beatrice Research Centre 1 Cadogan Gardens SW3 2RJ London UKV. V. Kakkar, Thrombosis Research Institute Emmanuel Kaye Building, Manres...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Vii international symposium of the autonomic nervous system: abstracts
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VII International Symposium of the Autonomic Nervous System: Abstracts
Content Type Journal ArticleDOI 10.1007/BF02556299Authors
Organizers, VII International Symposium of the Autonomic Nervous System: Abstracts
Journal Clinical Autonomic ResearchOnline ISSN 1619-1560Print ISSN 0959-9851
Journal Volume Volume 6
Journal Issue Volume 6, Number 5 / October, 1996 (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Neurohumoral, peptidergic and biochemical responses to supine exercise in two groups with primary autonomic failure: shy-drager syndrome/multiple system atrophy and pure autonomic failure
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In conclusion, neither exercise-induced
hypotension, nor the differences between SDS and PAF could be related to abnormalities in the release of A, PRA, insulin,
glucose or GH. The abnormal NA response to exercise was consistent with the BP fall being due to inadequate compensatory sympathetic
activity. In SDS, the small NA increase, in the presence of supersensitivity, may have reduced their BP fall as compared to
PAF. These results suggest that impaired sympathetic neural activity is a key factor in execise-induced hypotension.
Content Type Journal ArticleCategory Research PapersDOI 10.1007/BF02556296Authors
G. ...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Reproducibility of the cold pressor test: studies in normal subjects
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Abstract The reproducibility of the cold pressor test was studied in healthy subjects. A non-invasive method was utilized for estimating
beat-to-beat arterial blood pressure (BP) and heart rate (HR). The study population of 17 healthy volunteers consisted of
two groups. In the first group (Group 1, n=11), a 1-min test was performed three times during the same day. In the second
group (Group 2, n=6), a 2-min test was repeated at the same time of the day on three consecutive days. In both groups, the
test response was defined as the 46- to 60-s mean, minus the prestimulus 15 s baseline mean. In Group 1, a fair...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
The effects of lidocaine on cardiac parasympathetic control in normal subjects and in subjects after myocardial infarction
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Abstract It has been widely accepted that lidocaine has little or no effect on the autonomic nervous system. However, we have previously
shown that in dogs with vagally induced atrial fibrillation, lidocaine has a pronounced parasympatholytic effect. To study
the possible effect of lidocaine on autonomic cardiac control in humans, we performed spectral analysis of heart rate fluctuations
in 19 healthy volunteers, who received an i.v. bolus of lidocaine (1.4 mg/kg), as well as in 13 patients suffering from acute
inferior myocardial infarction (IMI) and 13 patients suffering from acute anterior myocardial infa...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Decreased vagal power during treadmill walking in patients with chronic fatigue syndrome
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Abstract The purpose of this study was to determine if patients with the chronic fatigue syndrome have less vagal power during walking
and rest periods following walking, in comparison to a group of healthy controls. Eleven patients (ten women and one man)
who fulfilled the case definition for chronic fatigue syndrome modified to reduce heterogeneity and eleven healthy, but sedentary,
age- and sex-matched controls walked on a treadmill at 2.5 mph four times each for 4 min duration. Between each period of
walking, subjects were given a 4-min seated rest period. Vagal power, a Fourier-based measure of cardiac,...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Head-up tilt table test: how far and how long?
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Abstract There is great variation between laboratories in the angle and duration of tilt used in the head-up tilt table test. We compared
the hemodynamic response to three sequential randomized 20-min tilts of 60°, 80° and 90° in 20 normal subjects. We studied
66 patients to determine the duration of tilt needed to document three types of orthostatic intolerance. Blood pressure and
heart rate were monitored non-invasively. Thirty-nine patients with orthostatic hypotension of diverse causes and 17 patients
with orthostatic tachycardia plus were tilted to 90° for 10 min. Ten patients with vasovagal syncope...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Programme
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Content Type Journal ArticleCategory VII International Symposium of the Autonomic Nervous System Radisson Gouverneurs Montreal Montreal, Quebec, Canada 11–13 October 1996DOI 10.1007/BF02556298
Journal Clinical Autonomic ResearchOnline ISSN 1619-1560Print ISSN 0959-9851
Journal Volume Volume 6
Journal Issue Volume 6, Number 5 / October, 1996 (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Estimation of fast vagal response by time-dependent analysis of heart rate variability in normal subjects
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In this study, the selective windowed discrete Fourier transform algorithm (SDA) for time-frequency analysis was applied on
non-stationary heart rate signals, recorded during vagal perturbations. These perturbations were achieved in healthy subjects
(aged 6–42 years) by inducing the oculocardiac reflex and the diving response. The results showed that the SDA can detect
and quantify the expected, although brief, increase in vagal tone, by displaying a marked transient increase in the respiratory
peak of the time-dependent spectrum. It allowed us to demonstrate an age-dependent reduction of the vagal response, obtained...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
The effects of midazolam and ephedrine on post-exercise autonomic chronotropic control of the heart in normal subjects
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In conclusion, midazolam induced unexpectedly great changes in dynamic cardiac control during cardiovascular stimulation.
Ephedrine increased tonic sympathetic activity and stabilized the neural circulatory control of the heart by immobilizing
dynamic parasympathetic activation.
Content Type Journal ArticleCategory Research PaperDOI 10.1007/BF02556305Authors
A. Lindqvist, Central Military Hospital Research Institute of Military Medicine Helsinki FinlandJ. Jalonen, University of Turku Cardiorespiratory Research Unit Turku FinlandL. A. Laitinen, Central Military Hospital Research Institute of Military Medicine Helsink...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Report on the vii international symposium of the autonomic nervous system
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Report on the VII international symposium of the autonomic nervous system
Content Type Journal ArticleCategory Meeting ReportDOI 10.1007/BF02556307Authors
David H. P. Streeten, American Autonomic Society USA
Journal Clinical Autonomic ResearchOnline ISSN 1619-1560Print ISSN 0959-9851
Journal Volume Volume 6
Journal Issue Volume 6, Number 6 / December, 1996 (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Use of corrected qt interval in autonomic function testing: assessment of reproducibility
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Abstract QT interval duration is influenced by the autonomic nervous system and has been proposed as an additional tool in the diagnosis
of diabetic autonomic neuropathy. The study aimed to assess in normal subjects the reproducibility of QT interval duration
compared with that of cardiovascular tests commonly used to explore the function of the autonomic nervous system. Fifty-nine
healthy subjects (31 males, 28 females; mean age 35.1 ±17.7 years) performed five cardiovascular tests: deep breathing test
(DBT), lying to standing test (LST), Valsalva manoeuvre (VM), postural blood pressure test (PBPT) and cou...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
Vasopressin release during orthostatic hypotension after cardiac transplantation
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Abstract At the time of cardiac transplantation all nerves from the donor ventricles are cut. These nerves may regrow, but there is
no method of measuring any regrowth. Arginine vasopressin (AVP) release was studied during hypotension induced by head-up
tilt and lower body negative pressure (LBNP) in transplant recipients and in normal controls. Subjects were tilted to 60°
for up to 60 min or until symptomatic. Lower body negative pressure (40 mmHg) was applied for 10 min after 30 min rest. Seven
of 17 transplant recipients and 11 of 12 controls became symptomatic during tilt testing, and 9 of 12 controls a...
Source: Clinical Autonomic Research - July 4, 2008 Category: Research Tags: Clinical Autonomic Research Source Type: journals
The structure of norc-associated rna is crucial for targeting the chromatin remodelling complex norc to the nucleolus
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Christine Mayer, Melanie Neubert & Ingrid Grummt (Source: EMBO Reports AOP)
Source: EMBO Reports AOP - July 4, 2008 Category: Research Authors: Christine MayerMelanie NeubertIngrid Grummt Tags: scientific report Source Type: journals
The yku70[ndash]yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle
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Michela Clerici, Davide Mantiero, Ilaria Guerini, Giovanna Lucchini & Maria Pia Longhese (Source: EMBO Reports AOP)
Source: EMBO Reports AOP - July 4, 2008 Category: Research Authors: Michela ClericiDavide MantieroIlaria GueriniGiovanna LucchiniMaria Pia Longhese Tags: scientific report Source Type: journals
Structural basis for rna-silencing suppression by tomato aspermy virus protein 2b
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Hong-Ying Chen, Jing Yang, Chengqi Lin & Y Adam Yuan (Source: EMBO Reports AOP)
Source: EMBO Reports AOP - July 4, 2008 Category: Research Authors: Hong-Ying ChenJing YangChengqi LinY Adam Yuan Tags: scientific report Source Type: journals
Deciphering the functional role of endothelial junctions by using in vivo models
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Daniel Nyqvist, Costanza Giampietro & Elisabetta Dejana (Source: EMBO Reports AOP)
Source: EMBO Reports AOP - July 4, 2008 Category: Research Authors: Daniel NyqvistCostanza GiampietroElisabetta Dejana Tags: review Source Type: journals
Silvio o. conte centers for basic and translational mental health research (p50)
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Program Announcement from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Geographic and contextual influences on energy balance-related health behaviors (r21)
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Program Announcement from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Geographic and contextual influences on energy balance-related health behaviors (r01)
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Program Announcement from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Pediatric critical care scientist development program [pccsdp] (k12)
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Request for Applications from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Measures and determinants of smokeless tobacco use, prevention, and cessation (r21)
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Request for Applications from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Measures and determinants of smokeless tobacco use, prevention, and cessation (r01)
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Request for Applications from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Interventions to remediate age-related cognitive decline (r01)
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Request for Applications from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Clarification: support for tl1/t32 postdoctoral trainees at institutional clinical and translational science awards
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Notice from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Nih implementation of government-wide standard terms and conditions for research grants
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Notice from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Notice of nih office of rare diseases opportunities for researchers to translate new genetic tests from laboratory to clinical testing: collaboration, education, and test translation (cett) program
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Notice from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Ahrq policy on submission of additional grant application materials
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Notice from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Corrections and additional information for rfa hl-08-012, nhlbi progenitor cell biology consortium planning awards (r03)
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Notice from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
The dual functions of thiol-based peroxidases in h2o2 scavenging and signaling
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Antioxidants & Redox Signaling Sep 2008, Vol. 10, No. 9: 1565-1576.
Thiol-based peroxidases consist of the peroxiredoxins (Prx) and the related glutathione peroxidase (GPx)-like enzymes. Their catalytic function is to reduce peroxides by using the reactivity of the cysteine residue, and their presumed primary physiologic ... (Source: Antioxidants)
Source: Antioxidants - July 3, 2008 Category: Research Tags: article Source Type: journals
Epilepsy research uk
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Fellowship Grant
Amount: > £100K
Closing Date : 17 October 2008
Project Grants
Amount: £50K - £100K
Closing Date : 17 October 2008 (Source: RDFunding RSS feed)
Source: RDFunding RSS feed - July 3, 2008 Category: Research Source Type: funding
Joint dms/nigms initiative to support research in the area of mathematical biology
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Notice from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 3, 2008 Category: Research Source Type: funding
Novel type of ras effector interaction established between tumour suppressor nore1a and ras switch ii
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Benjamin Stieglitz, Christine Bee, Daniel Schwarz, Ozkan Yildiz, Anna Moshnikova, Andrei Khokhlatchev and Christian Herrmann (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - July 3, 2008 Category: Research Authors: Benjamin StieglitzChristine BeeDaniel SchwarzOzkan YildizAnna MoshnikovaAndrei KhokhlatchevChristian Herrmann Tags: Article Source Type: journals
Mre11[ndash]rad50[ndash]nbs1-dependent processing of dna breaks generates oligonucleotides that stimulate atm activity
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Ali Jazayeri, Alessia Balestrini, Elizabeth Garner, James E Haber and Vincenzo Costanzo (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - July 3, 2008 Category: Research Authors: Ali JazayeriAlessia BalestriniElizabeth GarnerJames E HaberVincenzo Costanzo Tags: Article Source Type: journals
Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (grmd) dogs: local or systemic?
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Conclusions:
Our data suggested that systemic multiple deliveries seemed more effective than local injections. These findings open important avenues for further researches. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 3, 2008 Category: Research Authors: Irina Kerkis, Carlos E Ambrosio, Alexandre Kerkis, Daniele S Martins, Eder Zucconi, Simone AS Fonseca, Rosa M Cabral, Carlos MC Maranduba, Thais P Gaiad, Adriana C Morini, Natassia M Vieira, Marina P Brolio, Osvaldo A Sant'Anna, Maria A Miglino and Mayana Source Type: journals
Acute ethanol exposure attenuates pattern recognition receptor activated macrophage functions
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Journal of Interferon & Cytokine Research , Vol. 0, No. 0: 413-421.
Both clinical and experimental data have linked acute ethanol exposure to increased susceptibility to infection as well as increased morbidity and mortality after injury. Macrophages play an integral role in the innate immune system and are important in ... (Source: Journal of Interferon)
Source: Journal of Interferon - July 2, 2008 Category: Research Tags: article Source Type: journals
Brain cells that control where worms wander identified
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Research on the patterns of brain activity in Caenorhabditis elegans, the humble nematode worm, has identified how they taste salt and crawl toward high salt concentrations. (Source: Medical Research Council Research News)
Source: Medical Research Council Research News - July 2, 2008 Category: Research Source Type: organizations
Molecular cloning and characterization of chicken interferon-γ receptor α-chain
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In this study, a cDNA sequence of Huiyang chicken interferon-γ (IFN-γ) receptor α-chain (chIFNGR-1) gene wasgenerated using rapid amplification of cDNA ends (RACE) method for the first time. The predicted 422 amino acids showed ∼25%-29% sequence identity ... (Source: Journal of Interferon)
Source: Journal of Interferon - July 2, 2008 Category: Research Tags: article Source Type: journals
Administration of porcine interleukin-3 induces increased levels of blood eosinophils
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Journal of Interferon & Cytokine Research , Vol. 0, No. 0: 435-443.
Increasing resistance to anthelmintic drugs indicates a vital need to develop alternative strategies to control helminth infections. Interleukin-3 (IL-3) is a multilineage hematopoietic growth regulator produced by activated T lymphocytes in response to ... (Source: Journal of Interferon)
Source: Journal of Interferon - July 2, 2008 Category: Research Tags: article Source Type: journals
