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Structural basis for recognition of H3K56-acetylated histone H3–H4 by the chaperone Rtt106Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Structural basis for recognition of H3K56-acetylated histone H3–H4 by the chaperone Rtt106 Nature advance online publication 05 February 2012. doi:10.1038/nature10861 Authors: Dan Su, Qi Hu, Qing Li, James R. Thompson, Gaofeng Cui, Ahmed Fazly, Brian A. Davies, Maria Victoria Botuyan, Zhiguo Zhang & Georges Mer Dynamic variations in the structure of chromatin influence virtually all DNA-related processes in eukaryotes and are controlled in part by post-translational modifications of histones. One such modification, the acetylation of lysine 56 (H3K56ac) in the amino-terminal α-helix (αN) of histone H3...
Source: Nature AOP - February 5, 2012 Category: Research Authors: Dan SuQi HuQing LiJames R. ThompsonGaofeng CuiAhmed FazlyBrian A. DaviesMaria Victoria BotuyanZhiguo ZhangGeorges Mer Tags: Letter Source Type: research

Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
-Yong Wang Plants must coordinate the regulation of biochemistry and anatomy to optimize photosynthesis and water-use efficiency. The formation of stomata, epidermal pores that facilitate gas exchange, is highly coordinated with other aspects of photosynthetic development. The signalling pathways controlling stomata development are not fully understood, although mitogen-activated protein kinase (MAPK) signalling is known to have key roles. Here we demonstrate in Arabidopsis that brassinosteroid regulates stomatal development by activating the MAPK kinase kinase (MAPKKK) YDA (also known as YODA). Genetic analyses indicate t...
Source: Nature AOP - February 5, 2012 Category: Research Authors: Tae-Wuk KimMarta MichniewiczDominique C. BergmannZhi-Yong Wang Tags: Letter Source Type: research

DNase I sensitivity QTLs are a major determinant of human expression variationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DNase I sensitivity QTLs are a major determinant of human expression variation Nature advance online publication 05 February 2012. doi:10.1038/nature10808 Authors: Jacob F. Degner, Athma A. Pai, Roger Pique-Regi, Jean-Baptiste Veyrieras, Daniel J. Gaffney, Joseph K. Pickrell, Sherryl De Leon, Katelyn Michelini, Noah Lewellen, Gregory E. Crawford, Matthew Stephens, Yoav Gilad & Jonathan K. Pritchard The mapping of expression quantitative trait loci (eQTLs) has emerged as an important tool for linking genetic variation to changes in gene regulation. However, it remains difficult to identify the causal variants un...
Source: Nature AOP - February 5, 2012 Category: Research Authors: Jacob F. DegnerAthma A. PaiRoger Pique-RegiJean-Baptiste VeyrierasDaniel J. GaffneyJoseph K. PickrellSherryl De LeonKatelyn MicheliniNoah LewellenGregory E. CrawfordMatthew StephensYoav GiladJonathan K. Pritchard Tags: Letter Source Type: research

Serum IL-33 Levels Are Associated with Liver Damage in Patients with Chronic Hepatitis BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Interferon & Cytokine Research , Vol. 0, No. 0. (Source: Journal of Interferon)
Source: Journal of Interferon - February 3, 2012 Category: Research Tags: article Source Type: research

Redox Regulation of Mitochondrial FunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - February 3, 2012 Category: Research Tags: article Source Type: research

Men with Strokes Call for Help Quicker Than Women, Mayo Clinic Study SaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Mayo Clinic study, presented at the American Stroke Conference in New Orleans in early February, says that men experiencing a stroke call for emergency help quicker than women, especially if they are married. (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 3, 2012 Category: Research Authors: Mayo Clinic Source Type: news

Mitophagy: A Complex Mechanism of Mitochondrial RemovalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - February 3, 2012 Category: Research Tags: article Source Type: research

The Degradative Inventory of the Cell: Proteomic InsightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - February 3, 2012 Category: Research Tags: article Source Type: research

Vaccine development: Man vs MRSAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature 482, 7383 (2012). http://www.nature.com/doifinder/10.1038/482023a Author: Maryn McKenna For decades, Robert Daum has studied the havoc wreaked by methicillin-resistant Staphylococcus aureus. Now he thinks he can stop it for good. (Source: Nature)
Source: Nature - February 3, 2012 Category: Research Authors: Maryn McKenna Tags: Feature Source Type: research

Marine ecology: Attack of the blobsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature 482, 7383 (2012). http://www.nature.com/doifinder/10.1038/482020a Author: Mark Schrope Jellyfish will bloom as ocean health declines, warn biologists. Are they already taking over? (Source: Nature)
Source: Nature - February 3, 2012 Category: Research Authors: Mark Schrope Tags: Feature Source Type: research

Japan plans to merge major science bodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature 482, 7383 (2012). http://www.nature.com/doifinder/10.1038/482019a Author: Ichiko Fuyuno Drive to save money could increase bureaucracy. (Source: Nature)
Source: Nature - February 3, 2012 Category: Research Authors: Ichiko Fuyuno Tags: News Source Type: research

Genomics ace quits JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature 482, 7383 (2012). http://www.nature.com/doifinder/10.1038/482018a Author: David Cyranoski Yusuke Nakamura blames government inertia for his move to the United States. (Source: Nature)
Source: Nature - February 3, 2012 Category: Research Authors: David Cyranoski Tags: News Source Type: research

Seven days: 27 January–2 February 2012Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature 482, 7383 (2012). http://www.nature.com/doifinder/10.1038/482010a The week in science: sequencing stock rebounds after takeover bid for Illumina; drug companies and nations team up against neglected diseases; and turmoil at the Global Fund. (Source: Nature)
Source: Nature - February 3, 2012 Category: Research Tags: Seven Days Source Type: research

Rearranging the Cell's Skeleton- 2/1/12Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cell biologists at Johns Hopkins have identified key steps in how certain molecules alter a cell’s skeletal shape and drive the cell’s movement. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - February 3, 2012 Category: Research Source Type: news

New Technique Successfully Dissolves Blood Clots in the Brain and Lowers Risk of Brain Damage After Stroke- 2/2/12Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Johns Hopkins neurologists report success with a new means of getting rid of potentially lethal blood clots in the brain safely without cutting through easily damaged brain tissue or removing large pieces of skull. The minimally invasive treatment, they report, increased the number of patients with intracerebral hemorrhage (ICH) who could function independently by 10 to 15 percent six months following the procedure. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - February 3, 2012 Category: Research Source Type: news

Fighting malaria with one hand tied backEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malaria does not just kill babies and children under five – it kills adults too, in nearly as large proportionsDecades of assumptions about the lethality of malaria have been overturned by the publication of a paper in the Lancet from an academic institute in Seattle which says the disease kills twice as many as everybody thought. Even more extraordinary – it would seem that conventional wisdom about the disease has been wrong all this time.It does not just kill babies and children under five — it kills adults too, in nearly as large proportions.The Institute of Health Metrics and Evaluation has astounded the global ...
Source: Guardian Unlimited Science - February 3, 2012 Category: Science Authors: Sarah Boseley Tags: Malaria Society Global Fund to Fight Aids, Tuberculosis and Malaria Global development Infectious diseases Medical research Science The Guardian Analysis News Source Type: news

Development and characterization of highly polymorphic long TC repeat microsatellite markers for genetic analysis of peanutEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The microsatellite markers described here are a useful resource for genetics and genomics in Arachis. In particular, the 66 markers that are highly polymorphic in cultivated peanut are a significant step towards routine genetic mapping and marker-assisted selection for the crop. (Source: BMC Research Notes)
Source: BMC Research Notes - February 3, 2012 Category: Research Authors: Selma MacedoMarcio MoretzsohnSoraya Leal-BertioliDione AlvesEdiene GouveaVania AzevedoDavid Bertioli Source Type: research

Crisis-repair sequences - considerations on the classification and assessment of breaches in the therapeutic relationshipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The findings of the study give insight into basic mechanisms of change within the therapeutic relationship. A phenomenological discussion of how a crisis is defined is useful to create a methodological approach to the operationalization of crises, to differentiate specific characteristics and to specifically link these characteristics to the outcome in future studies. The methodological deliberations might be applyable to different research areas where the analysis of fluctuations in a variable of interest over time is relevant. (Source: BMC Medical Research Methodology - Latest articles)
Source: BMC Medical Research Methodology - Latest articles - February 3, 2012 Category: Research Authors: Antje GumzElmar BrahlerMichael GeyerRainer Erices Source Type: research

Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ATP7A overexpression played an important role in platinum-resistance of NSCLC, and was a negative prognostic factor of NSCLC patients treated with platinum-based chemotherapy. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 3, 2012 Category: Research Authors: Zhuang-hua LiMiao-zhen QiuZhao-lei ZengHui-yan LuoWen-jing WuFeng WangZhi-qiang WangDong-sheng ZhangYu-hong LiRui-hua Xu Source Type: research

Insights into Chi recognition from the structure of an AddAB-type helicase–nuclease complexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insights into Chi recognition from the structure of an AddAB-type helicase–nuclease complex The EMBO Journal. doi:10.1038/emboj.2012.9 Authors: Kayarat Saikrishnan, Joseph T Yeeles, Neville S Gilhooly, Wojciech W Krajewski, Mark S Dillingham & Dale B Wigley (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - February 3, 2012 Category: Research Authors: Kayarat SaikrishnanJoseph T YeelesNeville S GilhoolyWojciech W KrajewskiMark S DillinghamDale B Wigley Tags: Chi DNA recombination DNA repair Dna2 iron–sulphur cluster Article Source Type: research

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine releaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MF van Aalten (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - February 3, 2012 Category: Research Authors: Shalini PathakVladimir S BorodkinOsama AlbarbarawiDavid G CampbellAdel IbrahimDaan MF van Aalten Tags: cytokine glycobiology innate immunity O-GlcNAc signal transduction Article Source Type: research

Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
amp; Roger S Goody (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - February 3, 2012 Category: Research Authors: Philip R GoodyKatharina HellerLena K OesterlinMatthias P MüllerAymelt ItzenRoger S Goody Tags: Legionella phosphocholination Rab1 Rab35 Article Source Type: research

A role for α-adducin (ADD-1) in nematode and human memoryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A role for α-adducin (ADD-1) in nematode and human memory The EMBO Journal. doi:10.1038/emboj.2012.14 Authors: Vanja Vukojevic, Leo Gschwind, Christian Vogler, Philippe Demougin, Dominique J-F de Quervain, Andreas Papassotiropoulos & Attila Stetak (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - February 3, 2012 Category: Research Authors: Vanja VukojevicLeo GschwindChristian VoglerPhilippe DemouginDominique J-F de QuervainAndreas PapassotiropoulosAttila Stetak Tags: actin cytoskeleton adducin C. elegans episodic memory glutamate Article Source Type: research

Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
#243;, Ben Scheres & László Bögre (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - February 3, 2012 Category: Research Authors: Zoltán MagyarBeatrix HorváthSafina KhanBinish MohammedRossana HenriquesLieven De VeylderLászló BakóBen ScheresLászló Bögre Tags: Arabidopsis cell proliferation endocycle E2F retinoblastoma Article Source Type: research

Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
D Bell (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - February 3, 2012 Category: Research Authors: Thomas R BeattieStephen D Bell Tags: archaea DNA replication Okazaki fragment PCNA Article Source Type: research

Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Nissim Hay (Source: The EMBO Journal AOP)
Source: The EMBO Journal AOP - February 3, 2012 Category: Research Authors: Veronique NogueiraDeepa SundararajanJennifer M KwanXiao-ding PengNeha SarvepalliNahum SonenbergNissim Hay Tags: adipogenesis Akt eIF4E oncogenesis Skp2 Article Source Type: research

Exploring Sleepiness and Entrainment on Permanent Shift Schedules in a Physiologically Based ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effects of permanent shift work on entrainment and sleepiness are examined using a mathematical model that combines a model of sleep-wake switch in the brain with a model of the human circadian pacemaker entrained by light and nonphotic inputs. The model is applied to 8-hour permanent shift schedules to understand the basic mechanisms underlying changes of entrainment and sleepiness. Average sleepiness is shown to increase during the first days on the night and evening schedules, that is, shift start times between 0000 to 0700 h and 1500 to 2200 h, respectively. After the initial increase, sleepiness decreases and stab...
Source: Journal of Biological Rhythms - February 3, 2012 Category: Research Authors: Postnova, S., Layden, A., Robinson, P. A., Phillips, A. J. K., Abeysuriya, R. G. Tags: Articles Source Type: research

Transcription-Based Oscillator Model for Light-Induced Splitting as Antiphase Circadian Gene Expression in the Suprachiasmatic NucleiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Daily locomotor patterns of a variety of organisms have been interpreted as driven by dual circadian oscillators. Yet, in mammals, cellular data have revealed many circadian oscillators in the bilateral suprachiasmatic nucleus (SCN). To test how large numbers of oscillators could respond to environmental cues as a pair of oscillators, the authors developed a computational model composed of 2 groups of oscillators with strong local interactions and with weaker coupling between the 2 groups. Unlike previous models that assumed that light affects the timing or polarity of coupling between a pair of oscillators, this simulatio...
Source: Journal of Biological Rhythms - February 3, 2012 Category: Research Authors: Schroder, S., Herzog, E. D., Kiss, I. Z. Tags: Articles Source Type: research

Human Nonvisual Responses to Simultaneous Presentation of Blue and Red Monochromatic LightEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Blue light sensitivity of melatonin suppression and subjective mood and alertness responses in humans is recognized as being melanopsin based. Observations that long-wavelength (red) light can potentiate responses to subsequent short-wavelength (blue) light have been attributed to the bistable nature of melanopsin whereby it forms stable associations with both 11-cis and all-trans isoforms of retinaldehyde and uses light to transition between these states. The current study examined the effect of concurrent administration of blue and red monochromatic light, as would occur in real-world white light, on acute melatonin supp...
Source: Journal of Biological Rhythms - February 3, 2012 Category: Research Authors: Papamichael, C., Skene, D. J., Revell, V. L. Tags: Articles Source Type: research

Forced Desynchronization of Activity Rhythms in a Model of Chronic Jet Lag in MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we present a novel model of forced desynchronization in mice under a specific CJL schedule; in addition, our model provides theoretical tools for the evaluation of circadian disruption under CJL conditions that are currently used in circadian research. (Source: Journal of Biological Rhythms)
Source: Journal of Biological Rhythms - February 3, 2012 Category: Research Authors: Casiraghi, L. P., Oda, G. A., Chiesa, J. J., Friesen, W. O., Golombek, D. A. Tags: Articles Source Type: research

Rapid Assessment of Sleep-Wake Behavior in MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sleep is a fundamental biological rhythm involving the interaction of numerous brain structures and diverse neurotransmitter systems. The primary measures used to define sleep are the electroencephalogram (EEG) and electromyogram (EMG). However, EEG-based methods are often unsuitable for use in high-throughput screens as they are time-intensive and involve invasive surgery. As such, the dissection of sleep mechanisms and the discovery of novel drugs that modulate sleep would benefit greatly from further development of rapid behavioral assays to assess sleep in animal models. Here is described an automated noninvasive appro...
Source: Journal of Biological Rhythms - February 3, 2012 Category: Research Authors: Fisher, S. P., Godinho, S. I. H., Pothecary, C. A., Hankins, M. W., Foster, R. G., Peirson, S. N. Tags: Articles Source Type: research

The Ability to Entrain to Long Photoperiods Differs between 3 Drosophila melanogaster Wild-Type Strains and Is Modified by Twilight SimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ability to adapt to different environmental conditions including seasonal changes is a key feature of the circadian clock. Here, we compared the ability of 3 Drosophila melanogaster wild-type strains to adapt rhythmic activity to long photoperiods simulated in the laboratory. Fruit flies are predominantly crepuscular with activity bouts in the morning (M) and evening (E). The M peak follows dawn and the E peak follows dusk when the photoperiod is extended. We show that this ability is restricted to a certain extension of the phase angle between M and E peaks, such that the E peak does not delay beyond a certain phase u...
Source: Journal of Biological Rhythms - February 3, 2012 Category: Research Authors: Rieger, D., Peschel, N., Dusik, V., Glotz, S., Helfrich-Forster, C. Tags: Articles Source Type: research

Rhodopsin 5- and Rhodopsin 6-Mediated Clock Synchronization in Drosophila melanogaster Is Independent of Retinal Phospholipase C-{beta} SignalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Circadian clocks of most organisms are synchronized with the 24-hour solar day by the changes of light and dark. In Drosophila, both the visual photoreceptors in the compound eyes as well as the blue-light photoreceptor Cryptochrome expressed within the brain clock neurons contribute to this clock synchronization. A specialized photoreceptive structure located between the retina and the optic lobes, the Hofbauer-Buchner (H-B) eyelet, projects to the clock neurons in the brain and also participates in light synchronization. The compound eye photoreceptors and the H-B eyelet contain Rhodopsin photopigments, which activate th...
Source: Journal of Biological Rhythms - February 3, 2012 Category: Research Authors: Szular, J., Sehadova, H., Gentile, C., Szabo, G., Chou, W.-H., Britt, S. G., Stanewsky, R. Tags: Articles Source Type: research

Microarray Analysis of Natural Socially Regulated Plasticity in Circadian Rhythms of Honey BeesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study identified new putative clock-controlled genes in the honey bee and suggests that some brain functions show circadian rhythmicity even in nurse bees that are active around the clock. (Source: Journal of Biological Rhythms)
Source: Journal of Biological Rhythms - February 3, 2012 Category: Research Authors: Rodriguez-Zas, S. L., Southey, B. R., Shemesh, Y., Rubin, E. B., Cohen, M., Robinson, G. E., Bloch, G. Tags: Articles Source Type: research

A Baculovirus Photolyase with DNA Repair Activity and Circadian Clock Regulatory FunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cryptochromes and photolyases belong to the same family of flavoproteins but, despite being structurally conserved, display distinct functions. Photolyases use visible light to repair ultraviolet-induced DNA damage. Cryptochromes, however, function as blue-light receptors, circadian photoreceptors, or repressors of the CLOCK/BMAL1 heterodimer, the transcription activator controlling the molecular circadian clock. Here, we present evidence that the functional divergence between cryptochromes and photolyases is not so univocal. Chrysodeixis chalcites nucleopolyhedrovirus possesses 2 photolyase-like genes: phr1 and phr2. We s...
Source: Journal of Biological Rhythms - February 3, 2012 Category: Research Authors: Biernat, M. A., Eker, A. P. M., van Oers, M. M., Vlak, J. M., van der Horst, G. T. J., Chaves, I. Tags: Articles Source Type: research

Cancer Control and Prevention by Nutrition and Epigenetic ApproachesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - February 2, 2012 Category: Research Tags: article Source Type: research

Malaria kills twice as many people as previously thought, research findsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malaria kills 1.2 million people every year, a finding that has implications for global efforts to eliminate the diseaseMalaria kills twice as many people every year as formerly believed, taking 1.2 million lives and causing the deaths not only of babies but also older children and adults, according to research that overturns decades of assumptions about one of the world's most lethal diseases.The findings from the research, published on Friday, which has reanalysed 30 years of data on the disease using new techniques, will force a rethink of the huge global effort that has been under way to eliminate malaria. That ambitio...
Source: Guardian Unlimited Science - February 2, 2012 Category: Science Authors: Sarah Boseley Tags: Malaria Society Global Fund to Fight Aids, Tuberculosis and Malaria Global development World news Infectious diseases Medical research Science The Guardian Source Type: news

Protein Glutathionylation in the Regulation of Peroxiredoxins: A Family of Thiol-Specific Peroxidases That Function As Antioxidants, Molecular Chaperones, and Signal ModulatorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antioxidants & Redox Signaling Mar 2012, Vol. 16, No. 6: 506-523. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - February 2, 2012 Category: Research Tags: article Source Type: research

Regulation of Cell Physiology and Pathology by Protein S-Glutathionylation: Lessons Learned from the Cardiovascular SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antioxidants & Redox Signaling Mar 2012, Vol. 16, No. 6: 524-542. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - February 2, 2012 Category: Research Tags: article Source Type: research

Upcoming ConferencesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antioxidants & Redox Signaling Mar 2012, Vol. 16, No. 6: 633-633. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - February 2, 2012 Category: Research Tags: article Source Type: research

Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure. PMID: 22293651 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 2, 2012 Category: Research Authors: Simic-Ogrizovic S, Bogavac-Stanojevic N, Vuckovic M, Dopsaj V, Giga V, Kravljaca M, Stosovic M, Lezaic V Tags: Tohoku J Exp Med Source Type: research

Benefits from apical chest tube drainage in pneumothorax.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, inserting the tube from the apex could shorten the treatment period. PMID: 22293652 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 2, 2012 Category: Research Authors: Karasu S, Tokat AO, Cetinkanat CG, Karakaya J, Cakmak H, Aydin E, Yazici U, Gülhan E Tags: Tohoku J Exp Med Source Type: research

Should we really fear 'new flesh-eating bacteria'?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This interesting study helps explain why healthcare-acquired MRSA infections are rarely found in healthy individuals. It found that expression of a gene that produces one of the proteins responsible for MRSA’s antibiotic resistance caused it to be less toxic. It also showed that typical community-acquired MRSA strains express less of this antibiotic-resistance protein, but are more toxic. However, this intriguing lab study did not investigate the transmission, effects or number of cases of community-acquired MRSA in the UK, discussion of which formed the majority of the news reports. On this basis, the researc...
Source: NHS News Feed - February 2, 2012 Category: Consumer Health News Tags: Medical practice Source Type: news

Young Children Exposed to Anesthesia Multiple Times Show Elevated Rates of ADHDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mayo Clinic researchers have found that multiple exposures to anesthesia at a young age are associated with higher rates of attention-deficit/hyperactivity disorder (ADHD). (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 2, 2012 Category: Research Authors: Mayo Clinic Source Type: news

Siblings’ brain scans could hold the key to drug addictionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers funded by the Medical Research Council (MRC) have identified a brain abnormality which is found in drug-dependent individuals as well as their siblings who have had no history of drug addiction. (Source: Medical Research Council Press Releases)
Source: Medical Research Council Press Releases - February 2, 2012 Category: Consumer Health News Source Type: news

£4m boost for MRC-Asthma UK CentreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Medical Research Council (MRC) and GlaxoSmithKline (GSK) have co-funded a groundbreaking programme of asthma research at the MRC-Asthma UK Centre in Allergic Mechanisms of Asthma. (Source: Medical Research Council Research News)
Source: Medical Research Council Research News - February 2, 2012 Category: Research Source Type: news

Tumor necrosis factor-like weak inducer of apoptosis and its potential roles in lupus nephritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Introduction  Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a recently identified proinflammatory cytokine of the TNF superfamily that functions through binding to Fn14 receptor in target cells. TWEAK has multiple biological activities. Studies show that TWEAK plays an important role in immune inflammatory diseases. Recent work has revealed that TWEAK may play an important role in the pathogenesis of kidney damage, including in systemic lupus erythematosus (SLE), where its concentration in urine was correlated with the level of activity of lupus nephritis (LN). Objec...
Source: Inflammation Research - February 2, 2012 Category: Research Tags: Inflammation Research Source Type: research

TGFBR3 Variation is not a Common Cause of Marfan-like Syndrome and Loeys-Dietz-like SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Marfan syndrome (MFS) is caused by mutations in the fibrillin-1 (FBN1) gene, and mutations in FBN1 are known to be responsible for over 90% of all MFS cases. Locus heterogeneity has also been reported and confirmed, with mutations in the receptor genes TGFBR1 and TGFBR2 identified in association with MFS-related phenotypes. It is now known that dysregulation of TGF-beta signaling is involved in MFS pathogenesis. To test the hypothesis that dysregulation of TGFBR3- associated TGF-beta signaling is implicated in MFS or related phenotype pathogenesis, we selected a cohort of 49 patients, fulfilling or nearly fulfilling the di...
Source: Journal of Negative Results in BioMedicine - February 2, 2012 Category: Research Authors: Krishna SinghJoerg SchmidtkeBritta KeyserMine Arslan-Kirchner Source Type: research

Lipid droplet de novo formation and fission are linked to the cell cycle in fission yeastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cells sequester neutral lipids in bodies called lipid droplets. Thus, the formation and breakdown of the droplets are important for cellular metabolism; unfortunately, these processes are difficult to quantify. Here, we used time‐lapse confocal microscopy to track the formation, movement, and size changes of lipid droplets throughout the cell cycle in fission yeast Schizosaccharomyces pombe. In theory, the number of lipid droplets in these cells must increase for daughter cells to have the same number of droplets as the parent at a reference point in the cell cycle. We observed stable droplet formation events in G2 phase...
Source: Traffic - February 2, 2012 Category: Research Authors: Allan P. LongAnna K. ManneschmidtBobby VerBruggeMary R. DortchSteven C. MinkinKeith E. PraterJohn P. BiggerstaffJohn R. DunlapPaul Dalhaimer Source Type: research

Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Sanford-Burnham Medical Research Institute) In a paper published Feb. 3 in Cell, researchers at Sanford-Burnham Medical Research Institute identified a molecular switch that controls the protein Activating Transcription Factor 2 (ATF2), which is associated with poor prognosis in melanoma. This switch is controlled by protein kinase Cε (PKCε), which disables ATF2's tumor-suppressing activities, sensitizing cells to chemotherapy; Instead, ATF2's tumor-promoting activity is enhanced. The team also found that high levels of PKCε in melanoma are associated with poor prognosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 2, 2012 Category: Global & Universal Source Type: news