Respiratory MedicineThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory.

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A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Iloprost prevents bleomycin-induced pulmonary fibrosis, possibly by upregulating antifibrotic mediators (IFNgamma and CXCL10) and downregulating pro-inflammatory and pro-fibrotic cytokines (TNFalpha, IL-6, and TGFbeta1). Prostacyclin may represent a novel pharmacological agent for treating pulmonary fibrotic diseases. (Source: Respiratory Research)
Source: Respiratory Research - March 20, 2010 Category: Respiratory Medicine Authors: Yuanjue ZhuYong LiuWeixun ZhouRuolan XiangLei JiangKewu HuangYu XiaoZijian GuoJinming Gao Source Type: journals

Factors in infancy and childhood related to reduced lung function in asthmatic children: A birth cohort study (BAMSE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, school children with asthma have reductions of spirometric flows when categorized as persistent or transient early onset asthma, even if this latter group of children is completely symptom-free at school age. Pediatr Pulmonol. © 2010 Wiley-Liss, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 20, 2010 Category: Respiratory Medicine Authors: Jenny Hallberg, Martin Anderson, Magnus Wickman, Magnus Svartengren Source Type: journals

Exercise-induced wheeze: Fraction of exhaled nitric oxide-directed managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In patients with EIW and low FENO, the number of 'responders' to cromoglycate, formoterol and montelukast was similar. In a high FENO population the response to inhaled corticosteroid was highly significant and comparable to previous studies. (Source: Respirology)
Source: Respirology - March 20, 2010 Category: Respiratory Medicine Authors: Douglas C. COWAN, Richard S. HEWITT, Jan O. COWAN, Rochelle PALMAY, Avis WILLIAMSON, Samuel J.E. LUCAS, Carissa J. MURRELL, Kate N. THOMAS, D. Robin TAYLOR Source Type: journals

Mechanisms for lung function impairment and airway hyperresponsiveness following chronic hypoxia in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although chronic normobaric hypoxia (CH) alters lung function, its potential to induce bronchial hyperreactivity (BHR) is still controversial. Thus the effects of CH on airway and tissue mechanics separately and changes in lung responsiveness to methacholine (MCh) were investigated. To clarify the mechanisms, mechanical changes were related to end-expiratory lung volume (EELV), in vivo results were compared with those in vitro, and lung histology was assessed. EELV was measured plethysmographically in two groups of rats exposed to 21 days of CH (11% O2) or to normoxia. Total respiratory impedance was measured under baselin...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Habre, W., Janosi, T. Z., Fontao, F., Meyers, C., Albu, G., Pache, J.-C., Petak, F. Tags: ARTICLES Source Type: journals

Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We hypothesized that hypoxia would activate epidermal growth factor receptor (EGFR) tyrosine kinase, leading to increased arginase expression and resulting in proliferation of human pulmonary microvascular endothelial cell (hPMVEC). To test this hypothesis, hPMVEC were incubated in normoxia (20% O2, 5% CO2) or hypoxia (1% O2, 5% CO2). Immunoblotting for EGFR and proliferating cell nuclear antigen was done, and protein levels of both total EGFR and proliferating cell nuclear antigen were greater in hypoxic hPMVEC than in normoxic hPMVEC. Furthermore, hypoxic hPMVEC had greater levels of EGFR activity than did normoxic hPMVE...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Toby, I. T., Chicoine, L. G., Cui, H., Chen, B., Nelin, L. D. Tags: ARTICLES Source Type: journals

Synaptic and membrane properties of parasympathetic ganglionic neurons innervating mouse trachea and bronchiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, intracellular recordings were made from neurons in parasympathetic ganglia located on the trachea and bronchi of adult mice to determine electrophysiological properties associated with regulation of transmission of preganglionic input. Ganglionic neurons were characterized as having either tonic or phasic action potential accommodation patterns. Tonic neurons responded with repetitive action potentials sustained throughout a depolarizing current step, whereas phasic neurons generated one or a burst of action potential(s) and accommodated. A small subset displayed both patterns. Phasic neurons could be furthe...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Weigand, L. A., Myers, A. C. Tags: ARTICLES Source Type: journals

Airway smooth muscle remodels pericellular collagen fibrils: implications for proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Airway wall remodeling comprises a broad range of structural changes including increases in the volume of airway smooth muscle (ASM) and fibrillar collagen. The impact of fibrillar collagen remodeling on ASM proliferation was investigated. Human ASM cultured on type I fibrillar collagen remodeled the collagen substrate by both degradation (collagenolysis) and formation of networks comprised of thicker reticular collagen fibrils (fibrillogenesis). In cultures maintained on fibrillar collagen, the levels of matrix metalloproteases (MMPs) -1 and -14 mRNA and active MMP-2 were higher than in cultures maintained on nonfibrillar...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Schuliga, M., Ong, S. C., Soon, L., Zal, F., Harris, T., Stewart, A. G. Tags: ARTICLES Source Type: journals

Intrauterine growth restriction delays surfactant protein maturation in the sheep fetusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary surfactant is synthesized by type II alveolar epithelial cells to regulate the surface tension at the air-liquid interface of the air-breathing lung. Developmental maturation of the surfactant system is controlled by many factors including oxygen, glucose, catecholamines, and cortisol. The intrauterine growth-restricted (IUGR) fetus is hypoxemic and hypoglycemic, with elevated plasma catecholamine and cortisol concentrations. The impact of IUGR on surfactant maturation is unclear. Here we investigate the expression of surfactant protein (SP) A, B, and C in lung tissue of fetal sheep at 133 and 141 days of gestati...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Orgeig, S., Crittenden, T. A., Marchant, C., McMillen, I. C., Morrison, J. L. Tags: ARTICLES Source Type: journals

20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/AktEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have shown that 20-hydroxyeicosatetraenoic acid (20-HETE) increases both superoxide and nitric oxide (NO) production in bovine pulmonary artery endothelial cells (BPAECs). The current study was designed to determine mechanisms underlying 20-HETE-stimulated NO release, and particularly the role of NADPH oxidase, reactive oxygen species, and PI3-kinase in stimulated NO release. Intracellular hydrogen peroxide (H2O2) and NO production were detected by dichlorofluorescein or dihydrorhodamine and diaminofluorescein fluorescence, respectively. Activation of endothelial nitric oxide synthase (eNOS) (Ser1179) and Akt (Ser473) w...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Bodiga, S., Gruenloh, S. K., Gao, Y., Manthati, V. L., Dubasi, N., Falck, J. R., Medhora, M., Jacobs, E. R. Tags: ARTICLES Source Type: journals

Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we determined whether the anti-inflammatory effect of MUC1 is also operative during the respiratory syncytial virus (RSV) infection. The lung epithelial cell line A549 was treated with RSV, and the production of TNF and the levels of MUC1 protein were monitored temporally during the course of infection by ELISA and Western blot analysis. Small inhibitory RNA (siRNA) transfection was utilized to assess the role of MUC1 in regulating RSV-mediated inflammatory responses by lung epithelial cells. Our results revealed that: 1) following RSV infection, an increase in MUC1 level was preceded by an increase in TNF p...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Li, Y., Dinwiddie, D. L., Harrod, K. S., Jiang, Y., Kim, K. C. Tags: ARTICLES Source Type: journals

Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the data suggest that both Oct-4 isoforms are upregulated and potentially have a significant role in the development of vascular abnormalities associated with the pathogenesis of IPAH and in pulmonary hypertension triggered by chronic hypoxia. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Firth, A. L., Yao, W., Remillard, C. V., Ogawa, A., Yuan, J. X.-J. Tags: ARTICLES Source Type: journals

Reduction of collagen VII anchoring fibrils in the airway basement membrane zone of infant rhesus monkeys exposed to house dust miteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we determine whether HDM also affected deposition of collagen VII in the BMZ. In the developing airway of rhesus monkeys, the width of collagen VII anchoring fibrils in the BMZ was 0.02 ± 0.04 µm at 1 mo of age. At 6 mo the width had increased to 1.28 ± 0.34 µm and at 12 mo 2.15 ± 0.13 µm. In animals treated with HDM, we found a 42.2% reduction in the width of collagen VII layer in the BMZ at 6 mo (0.74 ± 0.15 µm; P < 0.05). During recovery, the rate of collagen VII deposition returned to normal. However, the amount of collagen VII lost was not recovered...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Evans, M. J., Fanucchi, M. V., Miller, L. A., Carlson, M. A., Nishio, S. J., Hyde, D. M. Tags: ARTICLES Source Type: journals

Mechanisms underlying epithelium-dependent relaxation in rat bronchioles: analogy to EDHF-type relaxation in rat pulmonary arteriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the mechanisms underlying epithelium-derived hyperpolarizing factor (EpDHF)-type relaxation in rat bronchioles. Immunohistochemistry was performed, and rat bronchioles and pulmonary arteries were mounted in microvascular myographs for functional studies. An opener of small (SKCa) and intermediate (IKCa)-conductance calcium-activated potassium channels, NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) was used to induce EpDHF-type relaxation. IKCa and SKCa3 positive immunoreactions were observed mainly in the epithelium and endothelium of bronchioles and arteries, respectively. In 5-hydroxytryptamine...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Kroigaard, C., Dalsgaard, T., Simonsen, U. Tags: ARTICLES Source Type: journals

Rapid effects of estrogen on intracellular Ca2+ regulation in human airway smooth muscleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The severity of asthma, a disease characterized by airway hyperresponsiveness and inflammation, is enhanced in some women during the menstrual cycle and during pregnancy but relieved in others. These clinical findings suggest that sex steroids modulate airway tone. Based on well-known relaxant effects of estrogens on vascular smooth muscle, we hypothesized that estrogens relax airway smooth muscle (ASM), thus facilitating bronchodilation. In ASM tissues from female patients, Western and immunocytochemical analyses confirmed the presence of both estrogen receptor (ER) isoforms, ER and ERβ. In fura 2-loaded, dissociated...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Townsend, E. A., Thompson, M. A., Pabelick, C. M., Prakash, Y. S. Tags: ARTICLES Source Type: journals

Rac1-mediated NADPH oxidase release of OFormula regulates epithelial sodium channel activity in the alveolar epitheliumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we report that Rac1-mediated NOX2 activity is an important component in O2– regulation of ENaC. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Takemura, Y., Goodson, P., Bao, H. F., Jain, L., Helms, M. N. Tags: ARTICLES Source Type: journals

Alterations in molecular chaperones and eIF2{alpha} during lung endothelial cell apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously demonstrated that inhibition of CAAX carboxyl methylation with AGGC caused redistribution and condensation of the ER molecular chaperones, glucose-regulated protein (GRP)-94 and calnexin; an effect that was attenuated by overexpression of dominant active RhoA. We have also shown that AGGC decreased GRP94 protein level; an effect that was dependent on caspase activity. In the present study, we tested the effects of inhibition of posttranslational processing of CAAX proteins on localization and protein levels of molecular chaperones and phosphorylation and protein level of eIF2. We found that both AGGC, wh...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Lu, Q., Jankowich, M., Newton, J., Harrington, E. O., Rounds, S. Tags: ARTICLES Source Type: journals

Adenovirus-mediated gene transfer of hIGF-IB in mouse lungs induced prolonged inflammation but no fibroproliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated whether human IGF-IB (hIGF-IB) expression in the lungs induces PF in a C57BL/6 mouse model. Mice were subjected to adenoviral gene transfer, and the effects of hIGF-IB expression on the lungs were examined 3, 7, 14, 21, and 42 days after gene delivery. hIGF-IB expression induced significant and prolonged inflammatory cell infiltration into the lungs, with an early neutrophil infiltration followed by a late macrophage infiltration. No significant fibroblast or matrix accumulation could be detected in the lungs of these mice. No significant collagen accumulation could be detected in vivo, despi...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Leger, C., Ni, A., Andonegui, G., Wong, J., Mowat, C., Winston, B. W. Tags: ARTICLES Source Type: journals

Gene expression profile in flow-associated pulmonary arterial hypertension with neointimal lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary arterial hypertension (PAH) is a pulmonary angioproliferative disease with high morbidity and mortality, characterized by a typical pattern of pulmonary vascular remodeling including neointimal lesions. In congenital heart disease, increased pulmonary blood flow has appeared to be a key mediator in the development of these characteristic lesions, but the molecular mechanisms underlying the pulmonary vascular lesions are largely unknown. We employed a rat model of flow-associated PAH, which induced specific pulmonary neointimal lesions. We identified gene expression profiles in rats specifically related to the add...
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: van Albada, M. E., Bartelds, B., Wijnberg, H., Mohaupt, S., Dickinson, M. G., Schoemaker, R. G., Kooi, K., Gerbens, F., Berger, R. M. F. Tags: ARTICLES Source Type: journals

A novel approach to analyze gene expression data demonstrates that the {Delta}F508 mutation in CFTR downregulates the antigen presentation pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our analysis suggests that the CF genotype may impair immune function in airway epithelial cells but may not increase inflammation. Additional studies are required to determine whether MHC class I gene repression in CF reduces antigen presentation at the protein level and whether repression impairs immune function. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - March 19, 2010 Category: Respiratory Medicine Authors: Hampton, T. H., Stanton, B. A. Tags: REVIEW Source Type: journals

Early-life chlamydial lung infection may increase future asthma severityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chlamydial lung infections in early life may influence immune responses and respiratory function, and increase the severity of asthma in later life, suggest results from a study in mice. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - March 19, 2010 Category: Respiratory Medicine Source Type: news

FDA Issues Final Rule Restricting Access And Marketing Of Cigarettes And Smokeless Tobacco Products To YouthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The U.S. Food and Drug Administration issued a final rule containing a broad set of federal requirements designed to significantly curb access to and the appeal of cigarettes and smokeless tobacco products to children and adolescents in the United States. Published March 19, 2010, the new rule becomes effective June 22, 2010, and has the force and effect of law... (Source: Smoking / Quit Smoking News From Medical News Today)
Source: Smoking / Quit Smoking News From Medical News Today - March 19, 2010 Category: Respiratory Medicine Tags: Smoking / Quit Smoking Source Type: news

Statement From American Heart Association CEO Nancy Brown On Congressional Approval Of The PACT ActEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We're pleased that Congress has taken another significant step in reducing tobacco use in the U.S. with passage of the Prevent All Cigarette Trafficking (PACT) Act of 2009. This measure will support ongoing efforts to protect children and adults from heart disease, stroke and other chronic illnesses linked to tobacco use... (Source: Smoking / Quit Smoking News From Medical News Today)
Source: Smoking / Quit Smoking News From Medical News Today - March 19, 2010 Category: Respiratory Medicine Tags: Smoking / Quit Smoking Source Type: news

Blocking Protein May Stem COPDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Blocking Protein May Stem COPDCategory: Health NewsCreated: 3/18/2010 10:10:00 AMLast Editorial Review: 3/19/2010 (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - March 19, 2010 Category: Respiratory Medicine Source Type: consumer

Prenatal Stress May Boost Baby's Asthma RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Prenatal Stress May Boost Baby's Asthma RiskCategory: Health NewsCreated: 3/18/2010 12:10:00 PMLast Editorial Review: 3/19/2010 (Source: MedicineNet Asthma General)
Source: MedicineNet Asthma General - March 19, 2010 Category: Respiratory Medicine Source Type: consumer

Respiratory impedance and response to salbutamol in asthmatic Vietnamese childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is a high incidence of pediatric asthma in Vietnam, but little lung function data are available. The aim of the study was to compare respiratory resistance (Rrs), reactance (Xrs), and responses to salbutamol between asthmatic and healthy primary school children in Hanoi. Because respiratory mechanics vary along the breathing cycle, measurements were assessed separately in inspiration (Rrsi, Xrsi) and expiration (Rrse, Xrse).Inpatients with doctor-diagnosed asthma were measured 2-3 days following admission using the forced oscillation technique at a single frequency (8 Hz). Z-scores and responses to salbutamol were co...
Source: Pediatric Pulmonology - March 19, 2010 Category: Respiratory Medicine Authors: Lan T.T. Vu, Bruno Demoulin, Mai T.H. Nguyen, Yen T. Nguyen, François Marchal Source Type: journals

Olive oil during pregnancy is associated with reduced wheezing during the first year of life of the offspringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To test the hypothesis that consuming Mediterranean diet and using olive oil for cooking/dressing salads during pregnancy might be associated with less wheezing during the first year of the offspring's life.A study was conducted in 1,409 infants (mean age, 16.6 ± 2.5 months) attending healthy infant clinics in Spain. Dietary data of mothers' intake during pregnancy was collected by means of a parental food frequency questionnaire. Demographic information and data on wheezing during the first year of the offspring's life were also recorded. Infants were stratified according to any wheezing (42.2%) during the first year of ...
Source: Pediatric Pulmonology - March 19, 2010 Category: Respiratory Medicine Authors: Jose A. Castro-Rodriguez, Luis Garcia-Marcos, Manuel Sanchez-Solis, Virginia Pérez-Fernández, Antonela Martinez-Torres, Javier Mallol Source Type: journals

Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis - a pilot randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first clinical trial in man of a QS inhibitor.We randomized 34 patients to garlic or olive oil capsules (both 656 mg daily). Clinical outcomes and safety bloods were measured at baseline and after 8 weeks treatment. In this exploratory study, analysis was per protocol.Eight patients withdrew, leaving 26 for analysis (13 garlic). With placebo, there was a greater decline in mean (SD) percentage change from baseline FEV1 [-3.6% (11.3)] than with garlic [-2.0% (12.3)]. This was not significant (mean difference = 1.6, 95% CI -12.7 to 15.9, P = 0.8). The mean (SD) increase in weight was greater with garlic [1.0% (...
Source: Pediatric Pulmonology - March 19, 2010 Category: Respiratory Medicine Authors: Alan R. Smyth, Paramita M. Cifelli, Catharine A. Ortori, Karima Righetti, Sarah Lewis, Penny Erskine, Elaine D. Holland, Michael Givskov, Paul Williams, Miguel Cámara, David A. Barrett, Alan Knox Source Type: journals

Effective aerosol delivery during high-frequency ventilation in neonatal pigsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Effective pulmonary aerosol delivery during HFOV was confirmed by contrast visualization in the kidneys within 30 min of aerosol initiation reflecting, alveolar absorption, glomerular filtration and renal concentration. (Source: Respirology)
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Beena G. SOOD, Yimin SHEN, Zahid LATIF, Bob GALLI, Elizabeth J. DAWE, E. Mark HAACKE Source Type: journals

Anti-angiogenesis drugs in lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the last years much attention has been given to the implementation of the so-called targeted drugs. One of the targets of tumours is the vasculature and this has led to the development of anti-angiogenic drugs. In lung cancer the use of these drugs has resulted in both positive and negative studies. In this paper the pros and cons are presented. We hope that this information will help the physician in making a proper treatment choice. (Source: Respirology)
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Siow Ming LEE, Paul BAAS, Heather WAKELEE Source Type: journals

Airline policies for passengers with obstructive sleep apnoea who require in-flight continuous positive airways pressureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Many airlines are unaware of CPAP. Those who are, have relatively consistent policies concerning the use of in-flight CPAP. (Source: Respirology)
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Jacqueline WALKER, Paul T. KELLY, Lutz BECKERT Source Type: journals

Serum levels of matrix metalloproteinase-9, tissue inhibitors of metalloproteinase-1 and their ratio are associated with impaired lung function in the elderly: A population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Lower FEV1 was significantly but weakly associated with higher serum levels of MMP-9, TIMP-1 and a higher MMP-9/TIMP-1 ratio. This association was stronger in men than in women, suggesting a possible role for extracellular matrix remodelling in the development of impaired lung function. These associations may also partly explain the association between low FEV1 and cardiovascular disease. (Source: Respirology)
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Inga S. ÓLAFSDÓTTIR, Christer JANSON, Lars LIND, Johannes HULTHE, María GUNNBJÖRNSDÓTTIR, Johan SUNDSTRÖM Source Type: journals

CCL22 is involved in the recruitment of CD4+CD25high T cells into tuberculous pleural effusionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CCL22 appeared to be increased in TPE compared with bacterial pleural effusions or transudates. CCL22 may be responsible for the infiltration of CD4+CD25high T cells into the pleural space of patients with tuberculous pleurisy. (Source: Respirology)
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Cong WU, Qiong ZHOU, Xue-Jun QIN, Shou-Ming QIN, Huan-Zhong SHI Source Type: journals

The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health statusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This 2-year study of a selected population of SARS survivors, showed significant impairment of DLCO, exercise capacity and health status persisted, with a more marked adverse impact among HCW. (Source: Respirology)
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Jenny C. NGAI, Fanny W. KO, Susanna S. NG, Kin-Wang TO, Mabel TONG, David S. HUI Source Type: journals

Gender differences in transcriptional regulation of IL-5 expression by bronchial lymph node cells in a mouse model of asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Greater antigen-induced Th2 cytokine production by bronchial lymph node cells from female mice was associated with enhanced Th2 cell differentiation and increased expression of the Th2-specific transcription factor, GATA-3. (Source: Respirology)
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Kana WADA, Kaori OKUYAMA, Yuichi OHKAWARA, Motoaki TAKAYANAGI, Isao OHNO Source Type: journals

Targeting abnormal airway vascularity as a therapeutical strategy in asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Asthma is a chronic inflammatory disease of airways, characterized by airway hyperresponsiveness and airflow limitation with acute bronchoconstriction, swelling of the airway wall, chronic mucus plug formation and airway wall remodelling. Functional and structural changes in the vasculature of asthmatic airways have been documented, and the signalling mechanisms are complex and have recently attracted much attention. The vascular changes may affect inflammatory cell recruitment, airway hyperresponsiveness and the regulation of airway calibre, and further, the level of disease control. Many critical factors are involved in ...
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Hee Sun PARK, Sun Young KIM, So Ri KIM, Yong Chul LEE Source Type: journals

Year in review 2009: Respiratory infections, tuberculosis, pleural diseases and lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Respirology)
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Stephen G. SPIRO, Michael NIEDERMAN, Wing W. YEW, José M. PORCEL Source Type: journals

Elevated alveolar nitric oxide concentration after environmental challenge in hypersensitivity pneumonitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 57-year-old male patient admitted to hospital with hypersensitivity pneumonitis (HP) that resolved without treatment. The total and alveolar nitric oxide (NO) concentrations were measured on initial admission and after re-exposure to his home environment. Following environmental exposure he became ill again, alveolar NO concentration was increased to the same level as on initial admission and impaired pulmonary function and radiologic abnormalities were found. It suggested a diagnosis of environmentally induced HP. The clinical value of measuring alveolar NO as an acute-phase reactant in HP is demonstrated in...
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Toshihiro SHIRAI, Masaki IKEDA, Satoru MORITA, Kazuhiro ASADA, Takafumi SUDA, Kingo CHIDA Source Type: journals

CysA2: A candidate serodiagnostic marker for Mycobacterium tuberculosis infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings suggest that CysA2 can be used in combination with HspX and/or PstS1 to increase the accuracy of tuberculosis diagnoses. (Source: Respirology)
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Go-Eun CHOI, Sun-Ho EOM, Ki-Hwan JUNG, Ji-Woong SON, A-Rum SHIN, Sung-Jae SHIN, Ki-Hye KIM, Chulhun L. CHANG, Hwa-Jung KIM Source Type: journals

Drug-resistant tuberculosis: Past, present, futureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a population of Mycobacterium tuberculosis, random chromosomal mutation that results in genetic resistance to anti-tuberculosis (TB) drugs occurs at a relatively low frequency. Anti-TB drugs impose selection pressure so that mycobacterial mutants gradually outnumber susceptible bacilli and emerge as the dominant strains. Resistance to two or more anti-TB drugs represents cumulative results of sequential mutation. The fourth report on global anti-TB drug resistance provides the latest data on the extent of such problem in the world. The median prevalence of multi-drug-resistant TB (MDR-TB) in new TB cases was 1.6%, and i...
Source: Respirology - March 19, 2010 Category: Respiratory Medicine Authors: Chen-Yuan CHIANG, Rosella CENTIS, Giovanni Battista MIGLIORI Source Type: journals

Temazepam ‘does not reduce lung function in COPD patients’Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a preliminary Dutch study suggest that the benzodiazepine temazepam does not reduce circadian respiratory function in patients with severe chronic obstructive pulmonary disease who suffer from insomnia. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - March 19, 2010 Category: Respiratory Medicine Source Type: news

Peanut allergy linked to increased asthma morbidity in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The presence of peanut allergy is associated with a greater number of hospitalizations and increased systemic steroid use in children with asthma, research shows. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - March 19, 2010 Category: Respiratory Medicine Source Type: news

Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study demonstrates for the first time the expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases and suggests sCD14 as potential marker for pneumonia in children. (Source: Respiratory Research)
Source: Respiratory Research - March 19, 2010 Category: Respiratory Medicine Authors: Veronica MarcosPhilipp LatzinAndreas HectorSebastian SonaniniFlorian HoffmannMartin LacherBarbara KollerPhilip BuflerThomas NicolaiDominik HartlMatthias Griese Source Type: journals

Whole genome evaluation of horizontal transfers in the pathogenic fungus Aspergillus fumigatusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mallet LV, Becq J, Deschavanne P (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - March 19, 2010 Category: Respiratory Medicine Source Type: consumer

Am J Physiol Lung Cell Mol Physiol; +23 new citationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Lung Cell Mol Physiol These pubmed results were generated on 2010/03/18PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 18, 2010 Category: Respiratory Medicine Tags: Report Source Type: journals

VOC breath profiling may help diagnose COPDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The presence of six volatile organic compounds in breath can accurately distinguish patients with chronic obstructive disease from those without the condition, research shows. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - March 18, 2010 Category: Respiratory Medicine Source Type: news

Inhaled Nitric Oxide Prevents 3-Nitrotyrosine Formation in the Lungs of Neonatal Mice Exposed to >95% OxygenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Inhaled nitric oxide is being evaluated as a preventative therapy for patients at risk for bronchopulmonary dysplasia (BPD). Nitric oxide (NO), in the presence of superoxide, forms peroxynitrite, which reacts with tyrosine residues on proteins to form 3-nitrotyrosine (3-NT). However, NO can also act as an antioxidant and was recently found to improve the oxidative balance in preterm infants. Thus, we tested the hypothesis that the addition of a therapeutically relevant concentration (10 ppm) of NO to a hyperoxic exposure would lead to decreased 3-NT formation in the lung. FVB mouse pups were ex...
Source: Lung - March 18, 2010 Category: Respiratory Medicine Tags: Lung Source Type: journals

New Technique Reduces Tobacco Smoke Damage To Lungs In MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers in Australia have demonstrated that blocking a certain protein can reduce or prevent cigarette smoke-induced lung inflammation in mice. Inflammation underlies the disease process of chronic obstructive pulmonary disease (COPD) and many other smoking-related ailments... (Source: Asthma / Respiratory News From Medical News Today)
Source: Asthma / Respiratory News From Medical News Today - March 18, 2010 Category: Respiratory Medicine Tags: Smoking / Quit Smoking Source Type: news

Gays, Lesbians Excluded From Some Medical StudiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Gays, Lesbians Excluded From Some Medical StudiesCategory: Health NewsCreated: 3/17/2010 6:10:00 PMLast Editorial Review: 3/18/2010 (Source: MedicineNet Asthma General)
Source: MedicineNet Asthma General - March 18, 2010 Category: Respiratory Medicine Source Type: consumer

How to Treat Kids' Hard-to-Control AsthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: How to Treat Kids' Hard-to-Control AsthmaCategory: Health NewsCreated: 3/17/2010 4:23:00 PMLast Editorial Review: 3/18/2010 (Source: MedicineNet Asthma General)
Source: MedicineNet Asthma General - March 18, 2010 Category: Respiratory Medicine Source Type: consumer

Cystic Fibrosis Pulmonary Guidelines: Pulmonary Complications: Hemoptysis and Pneumothorax.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These recommendations for the management of the CF patient with hemoptysis and pneumothorax are designed for general use in most individuals but should be adapted to meet specific needs as determined by the individuals, their families, and their health care providers. It is hoped that the guidelines provided in this manuscript will facilitate the appropriate application of these treatments to improve and extend the lives of all individuals with cystic fibrosis. PMID: 20299528 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 18, 2010 Category: Respiratory Medicine Authors: Flume PA, Mogayzel Jr PJ, Robinson KA, Rosenblatt RL, Quittell L, Marshall BC, Clinical Practice Guidelines For Pulmonary Therapies Committee Tags: Am J Respir Crit Care Med Source Type: journals