Respiratory Medicine 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
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Mixed approach encourages physical activity in asthma patients
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A multicomponent protocol can lead to clinically significant increases in physical activity among patients with asthma, US researchers report. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - February 3, 2012 Category: Respiratory Medicine Source Type: news
Oral voriconazole versus intravenous low dose amphotericin B for primary antifungal prophylaxis in pediatric acute leukemia induction: a prospective, randomized, clinical studyEmail this article to a colleague.
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Mandhaniya S, Swaroop C, Thulkar S, Vishnubhatla S, Kabra SK, Xess I, Bakhshi S (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 3, 2012 Category: Respiratory Medicine Source Type: news
Aspergillus myosin-V supports polarized growth in the absence of microtubule-based transportEmail this article to a colleague.
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Zhang J, Tan K, Wu X, Chen G, Sun J, Reck-Peterson SL, Hammer JA 3rd, Xiang X (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 3, 2012 Category: Respiratory Medicine Source Type: news
Low Interleukin-17A Production in Response to Fungal Pathogens in Patients with Chronic Granulomatous DiseaseEmail this article to a colleague.
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Smeekens SP, Henriet SS, Gresnigt MS, Joosten LA, Hermans PW, Netea MG, Warris A, van de Veerdonk FL (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 3, 2012 Category: Respiratory Medicine Source Type: news
Intracranial Aspergillus granulomaEmail this article to a colleague.
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Sundaram C, Murthy JM (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 3, 2012 Category: Respiratory Medicine Source Type: news
Response to: Lack of intra-laboratory reproducibility in using Platelia Aspergillus enzyme immunoassay test for detection of Aspergillus galactomannan antigenEmail this article to a colleague.
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Bizzini A, Marchetti O, Meylan P (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 3, 2012 Category: Respiratory Medicine Source Type: news
Indole alkaloids from marine-derived fungus Aspergillus sydowii SCSIO 00305Email this article to a colleague.
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He F, Sun YL, Liu KS, Zhang XY, Qian PY, Wang YF, Qi SH (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 3, 2012 Category: Respiratory Medicine Source Type: news
Recovery of aerobic and anaerobic bacteria in sinus fungal ballEmail this article to a colleague.
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Brook I (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 3, 2012 Category: Respiratory Medicine Source Type: news
Countering health threats by chemicals with a potential terrorist background - creating a rapid alert system for Europe.Email this article to a colleague.
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CONCLUSION: The RAS-CHEM database works and will be integrated into the Health Emergency Operations Facility (HEOF) with other European Rapid Alert Systems. Poisons centres receive a large number of enquiries and could be important sentinels in this field of toxicovigilance.
PMID: 22284259 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Schaper A, Desel H, Wyke S, Orford R, Griffiths MR, Edwards N, Kupferschmidt H, Mathieu M, Pelclova D, Duarte-Davidson R Tags: Eur J Intern Med Source Type: research
Thoracic Ultrasound Demonstrates Variable Location of the Intercostal ArteryEmail this article to a colleague.
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Respiration (DOI:10.1159/000330920) (Source: Respiration)
Source: Respiration - February 2, 2012 Category: Respiratory Medicine Source Type: research
IL-6 and IL-13 in Induced Sputum of COPD and Asthma Patients: Correlation with Respiratory TestsEmail this article to a colleague.
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Respiration (DOI:10.1159/000334900) (Source: Respiration)
Source: Respiration - February 2, 2012 Category: Respiratory Medicine Source Type: research
A Computer Model for the Simulation of Nonspherical Particle Dynamics in the Human Respiratory TractEmail this article to a colleague.
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In the study presented here deposition of spheres and nonspherical particles with various aspect ratios (0.01–100) in the human respiratory tract was theoretically modeled. Shape of the nonspherical particles was considered by the application of the latest aerodynamic diameter concepts. Particle deposition was predicted by using a stochastic model of the lung geometry and simulating particle transport trajectories according to the random-walk algorithm. Concerning fibers total deposition is significantly enhanced with respect to that of spheres for μm-sized particles, whereby at normal breathing conditions per...
Source: Advances in Pharmacological Sciences - February 2, 2012 Category: Drugs & Pharmacology Source Type: research
Anesthetic Management of Direct Laryngoscopy and Dilatation of Subglottic Stenosis in a Patient with Severe Myasthenia GravisEmail this article to a colleague.
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We describe the anesthetic management of a patient with severe myasthenia gravis and tracheal stenosis; the patient was scheduled for direct laryngoscopy and dilatation. The combination of myasthenia gravis and tracheal obstruction presents several difficulties for anesthetic management. The airway is shared; therefore, any complications are also shared by the anesthesiologist and bronchoscopists. The potential for respiratory compromise in patients undergoing the two procedures requires that anesthesiologists be familiar with the underlying disease state, as well as the interaction of anesthetic and nonanesthetic drugs in...
Source: Advances in Pharmacological Sciences - February 2, 2012 Category: Drugs & Pharmacology Source Type: research
The Size 1 ProSeal™ laryngeal mask airway in infants: a randomized, noncrossover study with the Classic™ laryngeal mask airwayEmail this article to a colleague.
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Conclusions: We conclude that the size 1 PLMA is a stable, safe, and efficacious airway control device during neonatal and infant anesthesia, allowing higher peak airway pressure during positive pressure ventilation, with fewer mask displacements and gastric insufflations than the cLMA. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - February 2, 2012 Category: Anesthesiology Authors: Maite López‐GilIgnacio MantillaTeresa BlancoEnrique TeigellMónica HerviasRosa Fernández‐López Tags: ORIGINAL ARTICLE Source Type: research
Acid-Base Disorders in Patients with Chronic Obstructive Pulmonary Disease: A Pathophysiological ReviewEmail this article to a colleague.
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The authors describe the pathophysiological mechanisms leading to development of acidosis in patients with chronic obstructive pulmonary disease and its deleterious effects on outcome and mortality rate. Renal compensatory adjustments consequent to acidosis are also described in detail with emphasis on differences between acute and chronic respiratory acidosis. Mixed acid-base disturbances due to comorbidity and side effects of some drugs in these patients are also examined, and practical considerations for a correct diagnosis are provided. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory SymptomsEmail this article to a colleague.
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This study was conducted to prove a correlation between the detection of alimentary pulmonary fat phagocytosis and an increasing amount of proximal gastroesophageal reflux. It was assumed that proximal gastroesophageal reflux better correlates with aspiration than distal GER. Patients from 6 months to 16 years with unexplained recurrent wheezy bronchitis and bronchial hyperreactivity, or recurrent pneumonia with chronic cough underwent 24-hour double-channel pH monitoring and bronchoscopy with bronchoalveolar lavage (BAL). Aspiration of gastric content was determined by counting lipid laden alveolar macrophages from BAL sp...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Impaired phagocytosis among patients infected by the human immunodeficiency virus: implication for a role of highly active anti‐retroviral therapyEmail this article to a colleague.
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SummaryIn patients with human immunodeficiency virus (HIV) infection, neutrophil and monocyte functions, including phagocytosis, are impaired. The purpose of this study was to investigate changes of phagocytic function and respiratory burst occurring over the course of patients infected by the HIV‐1 virus. Treatment‐naive patients (group B), patients receiving highly active anti‐retroviral treatment (HAART) (group C) and patients in which HAART has failed (group D) were studied and compared with healthy volunteers (group A). Phagocytosis and oxidative burst were evaluated using commercially available kits. Results cl...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: C. MichailidisG. GiannopoulosV. VigklisK. ArmenisA. TsakrisP. Gargalianos Source Type: research
sulfamethoxazole and trimethoprim, Bactrim, SeptraEmail this article to a colleague.
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Title: sulfamethoxazole and trimethoprim, Bactrim, SeptraCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 2/2/2012 (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - February 2, 2012 Category: Respiratory Medicine Source Type: news
Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study.Email this article to a colleague.
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Conclusions:
200mcg/day of FP was as effective as 1000mcg/day in improving symptom control, airway inflammation, lung function and AHR in adults with mild to moderate asthma in the short term. Future studies should examine potential differential effects between low and high dose combination therapy (ICS/long acting beta agonist) on inflammation and airway remodeling over longer treatment periods. (Source: Respiratory Research)
Source: Respiratory Research - February 2, 2012 Category: Respiratory Medicine Authors: Melissa BaraketBrian OliverJanette BurgessSam LimGregory KingJudith Black Source Type: research
Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary diseaseEmail this article to a colleague.
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Conclusions:
A robust systemic inflammatory profile was associated with COPD. This profile was generally independent of disease severity. Because anti-tumor necrosis factor-alpha did not influence systemic inflammation, how to control the underlying pathology beyond symptom suppression remains unclear.Trial Registration: ClinicalTrials.gov, No.: NCT00056264. (Source: Respiratory Research)
Source: Respiratory Research - February 2, 2012 Category: Respiratory Medicine Authors: Matthew LozaRosemary WattFrederic BaribaudElliot BarnathanStephen Rennard Source Type: research
Mandibular distraction in neonates: indications, technique, resultsEmail this article to a colleague.
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Conclusion:
Mandibular Distraction Osteogenesis is a good solution in solving respiratory distress when other procedures are failed in paediatric patients with severe micrognatia. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - February 2, 2012 Category: Pediatrics Authors: Enrico SesennaAlice MagriCinzia MagnaniBruno BreviMarilena Anghinoni Source Type: research
Tracheal Colonization in Preterm Infants Supported with Nasal CPAPEmail this article to a colleague.
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Conclusion: The trachea of premature infants supported with CPAP is at risk for bacterial colonization. Predisposing factors, mechanisms and clinical implications of these novel findings need to be studied.© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society (Source: Pediatrics International)
Source: Pediatrics International - February 2, 2012 Category: Pediatrics Authors: Hany AlyMagda BadawyRania H. TomerakAmani A El‐KholyAbeer S. Hamed Source Type: research
Radiofrequency volumetric tissue reduction of the inferior turbinate in a sheep modelEmail this article to a colleague.
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Conclusions:The sheep model is useful for study of both the anatomic and histopathologic effects of endonasal procedures. Standard endoscopic instruments and acoustic rhinometry can be used in this model with reproducible results. In this pilot animal study, radiofrequency devices for inferior turbinate reduction demonstrated greater preservation of normal nasal mucosal respiratory epithelium when compared to monopolar electrosurgery. (Source: The Laryngoscope)
Source: The Laryngoscope - February 2, 2012 Category: ENT & OMF Authors: Kiran KakaralaWilliam C. FaquinMichael J. Cunningham Tags: Rhinology Source Type: research
Mediastinal goiter presenting with ventricular tachycardiaEmail this article to a colleague.
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ConclusionTo our knowledge, this case represents the first documented presentation of ventricular tachycardia as a unique and sole feature of mediastinal goiter. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)
Source: Head and Neck - February 2, 2012 Category: ENT & OMF Authors: Kevin C. GilbertMuthuswamy DhiwakarWilliam S. StevensK. Thomas Robbins Tags: Case Report Source Type: research
Venous thromboembolism in patients with head and neck cancer after surgeryEmail this article to a colleague.
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ConclusionThe incidence of VTE in patients with head and neck cancer after resection and microvascular reconstruction ranged from 1.4% to 5.8%. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)
Source: Head and Neck - February 2, 2012 Category: ENT & OMF Authors: Leo ThaiKate McCarnWilliam StottTammara WattsMark K. WaxPeter E. AndersenNeil D. Gross Tags: Original Article Source Type: research
The development of simple survival prediction models for blunt trauma victims treated at Asian emergency centersEmail this article to a colleague.
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Conclusion: These equations allow physicians to perform real-time assessments of survival by easy mental calculations at Asian emergency centers, which are overcrowded with blunt injury victims of traffic accidents. (Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine)
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - February 2, 2012 Category: Emergency Medicine Authors: Akio KimuraShinji NakaharaWitaya Chadbunchachai Source Type: research
Regional quantification of muscarinic acetylcholine receptors and β‐adrenoceptors in human airwaysEmail this article to a colleague.
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Conclusions and Implications. From the present radioligand binding approach with intact tissue segments, we constructed a distribution map of mAChRs and β‐adrenoceptors in human bronchus and lung parenchyma for the first time, providing important evidence for future pharmacotherapy and new drug development for respiratory disorders.© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - February 2, 2012 Category: Drugs & Pharmacology Authors: T. IkedaA. S. M. AnisuzzamanH. YoshikiM. SasakiT. KoshijiJ. UwadaA. NishimuneH. ItohI. Muramatsu Source Type: research
Nasal CPAP With 'Heliox' Can Spare Preemies From VentilatorsNasal CPAP With 'Heliox' Can Spare Preemies From VentilatorsEmail this article to a colleague.
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In preterm infants with respiratory distress syndrome, using heliox - 80% helium and 20% oxygen - with nasal CPAP reduces the need for mechanical ventilation. Reuters Health Information (Source: Medscape Pediatrics Headlines)
Source: Medscape Pediatrics Headlines - February 1, 2012 Category: Pediatrics Tags: Pediatrics News Source Type: news
Against Lung Cancer Cells: To Be, or Not to Be, That Is the ProblemEmail this article to a colleague.
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Tobacco smoke and radioactive radon gas impose a high risk for lung cancer. The radon-derived ionizing radiation and some components of cigarette smoke induce oxidative stress by generating reactive oxygen species (ROS). Respiratory lung cells are subject to the ROS that causes DNA breaks, which subsequently bring about DNA mutagenesis and are intimately linked with carcinogenesis. The damaged cells by oxidative stress are often destroyed through the active apoptotic pathway. However, the ROS also perform critical signaling functions in stress responses, cell survival, and cell proliferation. Some molecules enhance radiati...
Source: Research Letters in Nanotechnology - February 1, 2012 Category: Nanotechnology Source Type: research
Some Allergic Inflammation May Be Due To Exposure To Common Environmental BacteriaEmail this article to a colleague.
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Could some cases of asthma actually be caused by an allergic reaction to a common environmental bacteria? New research findings published in the Journal of Leukocyte Biology suggests that this idea may not be as far-fetched as it seems. In a research report appearing in the February 2012 print issue, researchers show a link between common environmental bacteria and airway inflammation... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 1, 2012 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news
Lungs Infected With Plague Bacteria Also Become Playgrounds For Other MicrobesEmail this article to a colleague.
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Among medical mysteries baffling many infectious disease experts is exactly how the deadly pneumonic plague bacterium, Yersinia pestis, goes undetected in the first few day of lung infection, often until it's too late for medical treatment. New research from the University of North Carolina at Chapel Hill School of Medicine has opened a door to the answer. Researchers led by William E. Goldman, PhD, professor and chair of microbiology and immunology at the University of North Carolina at Chapel Hilland a leading authority on Y... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 1, 2012 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news
First Drug to Target Cause of Cystic Fibrosis ApprovedEmail this article to a colleague.
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Title: First Drug to Target Cause of Cystic Fibrosis ApprovedCategory: Health NewsCreated: 2/1/2012 11:01:00 AMLast Editorial Review: 2/1/2012 (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - February 1, 2012 Category: Respiratory Medicine Source Type: news
Health Highlights: Jan. 31, 2012Email this article to a colleague.
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Title: Health Highlights: Jan. 31, 2012Category: Health NewsCreated: 1/31/2012 4:05:00 PMLast Editorial Review: 2/1/2012 (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - February 1, 2012 Category: Respiratory Medicine Source Type: news
Zimbabwe: Prevention Better Than Cure - MadzoreraEmail this article to a colleague.
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[The Herald]
ZIMBABWE is still experiencing a huge burden of communicable diseases with acute respiratory infections, intestinal infections, pulmonary tuberculosis, with HIV being among the top 10 causes of morbidity and mortality, a Cabinet minister has revealed. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - February 1, 2012 Category: Infectious Diseases Source Type: news
Surfactant Protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway modelEmail this article to a colleague.
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Conclusion:
These results display a possible mechanism of how SP-D can modulate the inflammatory response to inhaled allergen. (Source: Respiratory Research)
Source: Respiratory Research - February 1, 2012 Category: Respiratory Medicine Authors: Carsten SchlehBarbara Rothen-RutishauserFabian BlankHans LauensteinMatthias NassimiNorbert KrugArmin BraunVeit ErpenbeckPeter GehrJens Hohlfeld Source Type: research
Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control studyEmail this article to a colleague.
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Conclusions:
GRPR expression in non-cancerous bronchial epithelium was significantly associated with the presence of lung cancer in never and former smokers. The association in never and former smokers was found in males and females. Association with lung cancer did not differ by sex in any smoking group. (Source: Respiratory Research)
Source: Respiratory Research - February 1, 2012 Category: Respiratory Medicine Authors: Ann Marie EgloffAutumn Gaither DavisYongli ShuaiStephanie LandJoseph PilewskiJames LuketichRodney LandreneauYork MillerJennifer GrandisJill Siegfried Source Type: research
Relationship between body composition, inflammation and lung function in overweight and obese asthmaEmail this article to a colleague.
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Conclusions:
This study suggests that both body composition and inflammation independently affect lung function, with distinct differences between males and females. Lean tissue exacerbates the obese-asthma phenotype in females and the mechanism responsible for this finding warrants further investigation. (Source: Respiratory Research)
Source: Respiratory Research - February 1, 2012 Category: Respiratory Medicine Authors: Hayley ScottPeter GibsonManohar GargJeffrey PrettoPhilip MorganRobin CallisterLisa Wood Source Type: research
CorrigendumEmail this article to a colleague.
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(Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Tags: CORRIGENDA Source Type: research
Hypoxia-inducible factor-1{alpha} regulates KCNMB1 expression in human pulmonary artery smooth muscle cellsEmail this article to a colleague.
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In conclusion, HIF-1α increases KCNMB1 expression in response to hypoxia in hPASMC by binding to two HREs located at –3,540 to –3,311 of the KCNMB1 promoter. We speculate that selective modulation of KCNMB1 expression may serve as a novel therapeutic approach to address diseases characterized by an increase in vascular tone. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Authors: Ahn, Y.-T., Kim, Y.-M., Adams, E., Lyu, S.-C., Alvira, C. M., Cornfield, D. N. Tags: ARTICLES Source Type: research
GM-CSF provides autocrine protection for murine alveolar epithelial cells from oxidant-induced mitochondrial injuryEmail this article to a colleague.
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Exposure of mice to hyperoxia induces alveolar epithelial cell (AEC) injury, acute lung injury and death. Overexpression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the lung protects against these effects, although the mechanisms are not yet clear. Hyperoxia induces cellular injury via effects on mitochondrial integrity, associated with induction of proapoptotic members of the Bcl-2 family. We hypothesized that GM-CSF protects AEC through effects on mitochondrial integrity. MLE-12 cells (a murine type II cell line) and primary murine type II AEC were subjected to oxidative stress by exposure to 80% oxyg...
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Authors: Sturrock, A., Seedahmed, E., Mir-Kasimov, M., Boltax, J., McManus, M. L., Paine, R. Tags: ARTICLES Source Type: research
{beta}2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteersEmail this article to a colleague.
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This study shows, for the first time, that PDE4D5 is predominantly expressed in human ASM cells from people with and without asthma and that formoterol does not upregulate PDE4D protein production. This leads us to speculate that continual therapy with β2AR agonists is unlikely to cause PDE4-mediated tachyphylaxis. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Authors: Niimi, K., Ge, Q., Moir, L. M., Ammit, A. J., Trian, T., Burgess, J. K., Black, J. L., Oliver, B. G. G. Tags: ARTICLES Source Type: research
TGF-{beta} enhances deposition of perlecan from COPD airway smooth muscleEmail this article to a colleague.
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This study aimed to investigate functional properties of the different perlecan domains in relation to airway smooth muscle cells (ASMC). Primary human ASMC obtained from donors with asthma (n = 13), COPD (n = 12), or other lung disease (n = 20) were stimulated in vitro with 1 ng/ml transforming growth factor-β1 (TGF-β1) before perlecan deposition and cytokine release were analyzed. In some experiments, inhibitors of signaling molecules were added. Perlecan domains I–V were seeded on tissue culture plates at 10 μg/ml with 1 μg/ml collagen I as a control. ASM was incubated on top of the peptides before...
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Authors: Ichimaru, Y., Krimmer, D. I., Burgess, J. K., Black, J. L., Oliver, B. G. G. Tags: ARTICLES Source Type: research
The dopamine D2 receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscleEmail this article to a colleague.
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Dopamine receptors are G protein-coupled receptors that are divided into two subgroups, "D1-like" receptors (D1 and D5) that couple to the Gs protein and "D2-like" receptors (D2, D3, and D4) that couple to Gi. Although inhaled dopamine has been reported to induce bronchodilation in patients with asthma, functional expression of dopamine receptor subtypes has never been described on airway smooth muscle (ASM) cells. Acute activation of Gi-coupled receptors inhibits adenylyl cyclase activity and cAMP synthesis, which classically impairs ASM relaxation. In contrast, chronic activation of Gi-coupled receptors produces a parado...
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Authors: Mizuta, K., Zhang, Y., Xu, D., Masaki, E., Panettieri, R. A., Emala, C. W. Tags: ARTICLES Source Type: research
Alcohol reduces airway hyperresponsiveness (AHR) and allergic airway inflammation in miceEmail this article to a colleague.
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There is very limited knowledge about the effects of alcohol on airway hyperresponsiveness and inflammation in asthma. Historical accounts of alcohol administration to patients with breathing problems suggest that alcohol may have bronchodilating properties. We hypothesized that alcohol exposure will alter airway hyperresponsiveness (AHR) and pulmonary inflammation in a mouse model of allergic asthma. To test this hypothesis, BALB/c mice were fed either 18% alcohol or water and then sensitized and challenged with ovalbumin (OVA). AHR was assessed by means of ventilation or barometric plethysmography and reported as either ...
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Authors: Oldenburg, P. J., Poole, J. A., Sisson, J. H. Tags: ARTICLES Source Type: research
The role of low-level lactate production in airway inflammation in asthmaEmail this article to a colleague.
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The objective was to study aerobic glycolysis in human asthma and the role of this metabolic pathway in airway hyperreactivity and inflammation in a mouse model of asthma. Human peripheral blood and mouse spleen CD4 T cells were isolated by negative selection. T cell proliferation was measured by thymidine incorporation. Cytokines and serum lactate were measured by ELISA. Mouse airway hyperreactivity to inhaled methacholine was measured by a FlexiVent apparatus. The serum lactate concentration was significantly elevated in clinically stable asthmatic subjects compared with healthy and chronic obstructive pulmonary disease ...
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Authors: Ostroukhova, M., Goplen, N., Karim, M. Z., Michalec, L., Guo, L., Liang, Q., Alam, R. Tags: ARTICLES Source Type: research
PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migrationEmail this article to a colleague.
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The phosphoinositide-3 kinase/Akt pathway is a vital survival axis in lung epithelia. We previously reported that inhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a major suppressor of this pathway, results in enhanced wound repair following injury. However, the precise cellular and biomechanical mechanisms responsible for increased wound repair during PTEN inhibition are not yet well established. Using primary human lung epithelia and a related lung epithelial cell line, we first determined whether changes in migration or proliferation account for wound closure. Strikingly, we observed that ce...
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Authors: Mihai, C., Bao, S., Lai, J.-P., Ghadiali, S. N., Knoell, D. L. Tags: ARTICLES Source Type: research
Studies on the cell biology of interendothelial cell gapsEmail this article to a colleague.
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Pain, redness, heat, and swelling are hallmarks of inflammation that were recognized as early as the first century AD. Despite these early observations, the mechanisms responsible for swelling, in particular, remained an enigma for nearly two millennia. Only in the past century have scientists and physicians gained an appreciation for the role that vascular endothelium plays in controlling the exudation that is responsible for swelling. One of these mechanisms is the formation of transient gaps between adjacent endothelial cell borders. Inflammatory mediators act on endothelium to reorganize the cytoskeleton, decrease the ...
Source: AJP: Lung Cellular and Molecular Physiology - February 1, 2012 Category: Respiratory Medicine Authors: Ochoa, C. D., Stevens, T. Tags: REVIEW Source Type: research
Nutritional outcomes following gastrostomy in children with cystic fibrosisEmail this article to a colleague.
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ConclusionOur study suggests that children with CF who receive GTs are more likely to achieve BMI ≥50th percentile than matched children without GTs. Pediatr Pulmonol. © 2012 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 1, 2012 Category: Respiratory Medicine Authors: Gia M. BradleyKathryn A. CarsonAmanda R. LeonardPeter J. MogayzelMaria Oliva‐Hemker Tags: Original Article: Cystic Fibrosis Source Type: research
Lung aeration changes after lung recruitment in children with acute lung injury: A feasibility studyEmail this article to a colleague.
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ConclusionsLung recruitment results in improved lung aeration as detected by lung tomography. This is accompanied by improvements in oxygenation and ventilation. However, the clinical significance of these findings is uncertain. Transporting patients in early ALI to the CT‐scanner seems safe and feasible. Pediatr Pulmonol. © 2012 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 1, 2012 Category: Respiratory Medicine Authors: Juan P. BoriosiRonald A. CohenEvan SummersAnil SapruJames H. HansonGinny GildengorinVivienne NewmanHeidi R. Flori Tags: Original Article: Pulmonary Physiology Source Type: research
Increased 25‐hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary diseaseEmail this article to a colleague.
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Conclusions: 25‐HC production was enhanced in the airways of COPD patients and may play a role in neutrophilic inflammation.© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology (Source: Respirology)
Source: Respirology - February 1, 2012 Category: Respiratory Medicine Authors: Hisatoshi SugiuraAkira KoaraiTomohiro IchikawaYoshiaki MinakataKazuto MatsunagaTsunahiko HiranoKeiichiro AkamatsuSatoru YanagisawaMakoto FurusawaYumiko UnoMasashi YamasakiYoshinori SatomiMasakazu Ichinose Source Type: research
