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This page shows you the most recent publications within this specialty of the MedWorm directory.

Greater COPD guideline awareness needed in primary care
US study results show that primary care management of chronic obstructive pulmonary disease rarely conforms to the Global Initiative for Chronic Obstructive Lung Disease guidelines. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - May 20, 2013 Category: Respiratory Medicine Source Type: news

ARDS Survival Improved by Prone Position (CME/CE)
PHILADELPHIA (MedPage Today) -- Mortality in acute respiratory distress syndrome was cut in half in patients who had early and prolonged sessions of prone positioning, a multicenter randomized trial showed. (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - May 20, 2013 Category: Respiratory Medicine Source Type: news

Nebulized Arformoterol: Its Place in the Management of COPDNebulized Arformoterol: Its Place in the Management of COPD
Find out about the pharmacology and safety of arformoterol in patients with COPD. Therapeutic Advances in Respiratory Disease (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 20, 2013 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

What Is Its Place in the Management of COPD?What Is Its Place in the Management of COPD?
Find out about the pharmacology and safety of arformoterol in patients with COPD. Therapeutic Advances in Respiratory Disease (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 20, 2013 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Study: Older Whooping Cough Vaccine More Effective
But it was phased out because of side effects; newer version works, study notes (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 20, 2013 Category: Respiratory Medicine Authors: webmaster at doctorslounge.com Tags: Infections, Pediatrics, Pharmacy, Pulmonology, News, Source Type: news

Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry in Clinical Microbiology
Patel R (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - May 20, 2013 Category: Respiratory Medicine Source Type: news

Development of new measurement system of thoracic excursion with biofeedback: reliability and validity
Conclusion: The novel measurement system, BREATH, has high intra- and inter-evaluator reliabilities and validity; therefore it can lead us more effective respiratory exercise. Using its biofeedback data, this system may help patients with respiratory disease to do exercises more efficiently and clinicians to assess the respiratory exercise more accurately. (Source: Journal of NeuroEngineering and Rehabilitation)
Source: Journal of NeuroEngineering and Rehabilitation - May 20, 2013 Category: Rehabilitation Authors: Yukiko NishigakiHiroko MizuguchiEriko TakedaTomokazu KoikeTakeshi AndoKazuya KawamuraTakuro ShimboHidetoshi IshikawaMasashi FujimotoIkuko SaotomeReiko OdoKazuko OmodaShohei YamashitaTomoko YamadaToshihito OmiYuya MatsushitaManami TakedaSawako SekiguchiSak Source Type: research

Chronic respiratory disease, comorbid cardiovascular disease, and mortality in a representative adult U.S. cohort
ConclusionsIn this large US population‐based cohort, the presence of obstruction, restriction, or respiratory symptoms alone was associated with higher adjusted risk of overt CVD. (Source: Respirology)
Source: Respirology - May 20, 2013 Category: Respiratory Medicine Authors: David M. Mannino, Kourtney J. Davis, Rachael L. DiSantostefano Tags: Original Article Source Type: research

Oxidative stress and antioxidant enzyme activity in South Indian male smokers with Chronic Obstructive Pulmonary Disease
ConclusionOur study demonstrates that there is an oxidant antioxidant imbalance in COPD patients and suggests the importance of GPx in maintaining lung function. (Source: Respirology)
Source: Respirology - May 20, 2013 Category: Respiratory Medicine Authors: Arja Cholendra, Surapaneni Krishna Mohan, Raya Premanand, Adimoolam Chandrasekar, Balisetty Badhareenadhudu, Kanala Kodanda Reddy Tags: Original Article Source Type: research

Capability of hypertonic saline cough provocation test to predict the response to inhaled corticosteroids in chronic cough: a prospective, open-label study
Conclusions: Saline test cannot predict the responsiveness to inhaled corticosteroids in chronic cough but it may be utilized to monitor the effect of this treatment.Trial registration: The study was registered in ClinicalTrials.gov database (KUH5801112). ClinicalTrials.gov Identifier: NCT00859274 (Source: Cough)
Source: Cough - May 20, 2013 Category: Respiratory Medicine Authors: Heikki KoskelaMinna Purokivi Source Type: research

Endostatin, an angiogenesis inhibitor, ameliorates bleomycin-induced pulmonary fibrosis in rats
Conclusions: Our findings suggest that endostatin treatment inhibits the increased MVD, inflammation and alveolar epithelial cell apoptosis, consequently ameliorating BLM-induced pulmonary fibrosis in rats. (Source: Respiratory Research)
Source: Respiratory Research - May 20, 2013 Category: Respiratory Medicine Authors: Yun-Yan WanGuang-Yan TianHai-Sheng GuoYan-Meng KangZhou-Hong YaoXi-Li LiDian-Jie LinQing-Hua Liu Source Type: research

Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study
The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers. Methods: 3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Smoking status (quitted >=5, >=1- (Source: Respiratory Research)
Source: Respiratory Research - May 20, 2013 Category: Respiratory Medicine Authors: Firdaus Mohamed HoeseinPieter ZanenPim de JongBram van GinnekenH BoezenHarry GroenMathijs OudkerkHarry de KoningDirkje PostmaJan-Willem Lammers Source Type: research

Living Near Major Roadways in Pregnancy Tied to Respiratory Woes in Children
Infants may have higher risk for conditions like pneumonia, study found (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 20, 2013 Category: Respiratory Medicine Authors: webmaster at doctorslounge.com Tags: Infections, Pediatrics, Pulmonology, Obstetrics, Preventive Medicine, News, Source Type: news

Simulator Helps Asthma Patients Breathe Easier (CME/CE)
PHILADELPHIA (MedPage Today) -- A 5-minute test with a simulator helps asthma patients learn how to correctly use their inhalers, nearly doubling the chance of being in therapeutic range at the next visit, researchers reported here. (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - May 19, 2013 Category: Respiratory Medicine Source Type: news

Cystic Fibrosis: Charity and Industry Partner for Profit
(MedPage Today) -- When a disease-related charity becomes a venture capitalist, count the pharmaceutical industry among the winners, but the charity is not far behind as John Fauber explains in this Milwaukee Journal Sentinel/MedPage Today investigation. (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - May 19, 2013 Category: Respiratory Medicine Source Type: news

Cystic Fibrosis: Siblings Share the Patient Experience
(MedPage Today) -- Only 1,200 people in the U.S. have the specific genetic mutation that causes a rare form of cystic fibrosis -- two of them are a Wisconsin brother and sister, Charles and Paula Heup. The Heup siblings are taking Kalydeco to treat their disease. (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - May 19, 2013 Category: Respiratory Medicine Source Type: news

Acute fibrinous and organizing pneumonia associated with influenza A/H1N1 pneumonia after lung transplantation
Conclusion: To our knowledge we present the first case of AFOP triggered by viral infection, here proven to be influenza virus A/H1N1. Thus, also in the setting of viral infection the highly deadly differential diagnosis of AFOP must be considered. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - May 19, 2013 Category: Respiratory Medicine Authors: Claudia OttoDaniela HuzlyLars KemnaAnnegret HüttelChristoph BenkSiegbert RiegTill PloenesMartin WernerGian Kayser Source Type: research

An Impulse Radio Ultrawideband System for Contactless Noninvasive Respiratory Monitoring
We design a impulse radio ultrawideband radar monitoring system to track the chest wall movement of a human subject during respiration. Multiple sensors are placed at different locations to ensure that the backscattered signal could be detected by at least one sensor no matter which direction the human subject faces. We design a hidden Markov model to infer the subject facing direction and his or her chest movement. We compare the performance of our proposed scheme on $hbox{15}$ human volunteers with the medical gold standard using respiratory inductive plethysmography (RIP) belts, and show that on average, our estimation ...
Source: IEEE Transactions on Biomedical Engineering - May 18, 2013 Category: Biomedical Engineering Source Type: research

Evidence Of Host Adaptation Of Avian-Origin Influenza A Virus
A novel avian-origin reassortant influenza A (H7N9) virus emerged in China in February 2013, and is associated with severe lower respiratory tract diseases. To date, more than 100 human cases of infection, including at least 20 deaths, have been reported in China. Three early cases of infection were described in Hangzhou, Zhejiang Province, China. The general clinical features of the three patients were similar to the previously reported cases in China. Two of the three patients had a history of direct contact with live poultry markets... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2013 Category: Consumer Health News Tags: Bird Flu / Avian Flu Source Type: news

Airway Morphology From High Resolution Computed Tomography in Healthy Subjects and Patients With Moderate Persistent Asthma
In this study, a commercial software package was used to segment the airway tree of seven healthy and six moderately persistent asthmatic patients from high resolution computed tomography images. The process was assessed with regards to the treatment of the images of the asthmatic group. The in vivo results for the bronchial length, diameter, WT, branching, and rotation angles are reported and compared per generation for different lobes. Furthermore, some popular mathematical relationships between these morphometric characteristics were examined in order to verify their validity for both groups. Our results suggest that, e...
Source: The Anatomical Record Part B: The New Anatomist - May 17, 2013 Category: Anatomy Authors: Spyridon Montesantos, Ira Katz, John Fleming, Carolin Majoral, Marine Pichelin, Cecile Dubau, Benoit Piednoir, Joy Conway, Joëlle Texereau, Georges Caillibotte Tags: Cover Image Source Type: research

Efficacy, safety and tolerability of GSK2190915, a 5-lipoxygenase activating protein inhibitor, in adults and adolescents with persistent asthma: a randomised dose-ranging study
The objective of this study was to evaluate GSK2190915 efficacy, dose--response and safety in subjects with persistent asthma treated with short-acting beta2-agonists (SABAs) only. Methods: Eight-week multicentre, randomised, double-blind, double-dummy, stratified (by age and smoking status), parallel-group, placebo-controlled study in subjects aged >=12 years with a forced expiratory volume in 1 second (FEV1) of 50--85% predicted. Subjects (n = 700) were randomised to receive once-daily (QD) oral GSK2190915 (10--300 mg), twice-daily inhaled fluticasone propionate 100 mug, oral montelukast 10 mg QD or placebo. The primary ...
Source: Respiratory Research - May 17, 2013 Category: Respiratory Medicine Authors: Richard FollowsNeil SnowiseShu-Yen HoClaire AmberyKevin SmartBarbara McQuade Source Type: research

Questionnaire improves allergic rhinitis detection in asthma
Researchers have shown that the Self Assessment of Allergic Rhinitis and Asthma questionnaire is effective in identifying undiagnosed allergic rhinitis among asthma patients. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - May 16, 2013 Category: Respiratory Medicine Source Type: news

Respiratory Bug Not Always a Problem for Kids (CME/CE)
(MedPage Today) -- Many children with no signs of respiratory infection tested positive for Mycoplasma pneumoniae, suggesting that such tests may be unreliable for clinical diagnosis, researchers said. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - May 16, 2013 Category: Pediatrics Source Type: news

Prevalence of multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa in an Italian hospital
Summary: The severity and extent of disease caused by multidrug-resistant organisms (MDROs) varies by the population(s) affected and the institution(s) at which these organisms are found; therefore, preventing and controlling MDROs are extremely important.A retrospective study of patients who were infected with Acinetobacter baumannii or Pseudomonas aeruginosa was performed at the Spedali Civili Hospital in Brescia, Italy, from 2007 to 2010.A total of 167 (0.52%) A. baumannii isolates and 2797 P. aeruginosa (8.7%) isolates were identified among 31,850 isolates.Amikacin and colistin were the most active agents against A. ba...
Source: Journal of Infection and Public Health - May 16, 2013 Category: Global & Universal Authors: M.A. De Francesco, G. Ravizzola, L. Peroni, C. Bonfanti, N. Manca Tags: Original Papers Source Type: research

Do socioeconomic inequalities in mortality vary between different Spanish cities? a pooled cross-sectional analysis
Conclusions: This study provides a general overview of the relationship between deprivation and mortality for a sample of large Spanish cities combined. This joint study allows the exploration of and, if appropriate, the quantification of the variability in that relationship for the set of cities considered. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - May 16, 2013 Category: Consumer Health News Authors: Miguel Martinez-BeneitoOscar ZurriagaPaloma Botella-RocamoraMarc Marí-Dell'OlmoAndreu NolascoJoaquín MonchoAntonio DaponteM Domínguez-BerjónAna GandarillasCarmen MartosImanol MontoyaPablo Sánchez-VillegasMargarita TaracidoCarme Borrell Source Type: research

Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma (Review)
Abstract BackgroundDampness and mould in buildings have been associated with adverse respiratory symptoms, asthma and respiratory infections of inhabitants. Moisture damage is a very common problem in private houses, workplaces and public buildings such as schools. ObjectivesTo determine the effectiveness of remediating buildings damaged by dampness and mould in order to reduce or prevent respiratory tract symptoms, infections and symptoms of asthma. Search methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 2), which contains the Cochrane Acute Respiratory Infe...
Source: Evidence-Based Child Health: A Cochrane Review Journal - May 16, 2013 Category: Pediatrics Authors: Riitta Sauni, Jukka Uitti, Merja Jauhiainen, Kathleen Kreiss, Torben Sigsgaard, Jos H Verbeek Tags: Intervention Review Source Type: research

Commentaries on ‘Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma’
Abstract These are commentaries on a Cochrane review, published in the issue of EBCH, first published as: Sauni R, Uitti J, Jauhiainen M, Kreiss K, Sigsgaard T, Verbeek JH. Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma. Cochrane Database of Systematic Reviews 2011, Issue 9. Art. No.: CD007897. DOI: 10.1002/14651858.CD007897.pub2. (Source: Evidence-Based Child Health: A Cochrane Review Journal)
Source: Evidence-Based Child Health: A Cochrane Review Journal - May 16, 2013 Category: Pediatrics Authors: Helena Liira, Thomas Kovesi Tags: Commentary Source Type: research

Taste perception: from the tongue to the testis
In mammals, the sense of taste helps in the evaluation and consumption of nutrients, and in avoiding toxic substances and indigestible materials. Distinct cell types expressing unique receptors detect each of the five basic tastes: salty, sour, bitter, sweet and umami. The latter three tastes are detected by two distinct families of G protein-coupled receptors: T2Rs and T1Rs. Interestingly, these taste receptors have been found in tissues other than the tongue, such as the digestive system, respiratory system, brain, testis and spermatozoa. The functional implications of taste receptors distributed throughout the body are ...
Source: Molecular Human Reproduction - May 16, 2013 Category: Molecular Biology Authors: Li, F. Tags: New Research Horizon Reviews Source Type: research

Inactivity-induced phrenic and hypoglossal motor facilitation are differentially expressed following intermittent vs. sustained neural apnea
Reduced respiratory neural activity elicits a rebound increase in phrenic and hypoglossal motor output known as inactivity-induced phrenic and hypoglossal motor facilitation (iPMF and iHMF, respectively). We hypothesized that, similar to other forms of respiratory plasticity, iPMF and iHMF are pattern sensitive. Central respiratory neural activity was reversibly reduced in ventilated rats by hyperventilating below the CO2 apneic threshold to create brief intermittent neural apneas (5, ~1.5 min each, separated by 5 min), a single brief massed neural apnea (7.5 min), or a single prolonged neural apnea (30 min). Upon restorat...
Source: Journal of Applied Physiology - May 16, 2013 Category: Physiology Authors: Baertsch, N. A., Baker-Herman, T. L. Tags: ARTICLES Source Type: research

Antibody and CD8+ T cell memory response to influenza A/PR/8/34 infection is reduced in treadmill-exercised mice, yet still protective
Moderate exercise may decrease the severity of influenza infection and reduce lung viral load. The possibility that an exercise-associated reduction in lung viral load early in infection could contribute to decreased serum antibody and reduced memory response were investigated. BALB/c mice exercised for 8 wk and were then infected with influenza A/PR/8/34 (intranasal route). Influenza-specific serum antibody was assessed for 6 mo post primary infection, at which time mice were infected again with influenza A/PR/8/34. After primary infection, exercise reduced morbidity/mortality, attenuated lung cytokines, and decreased ser...
Source: Journal of Applied Physiology - May 16, 2013 Category: Physiology Authors: Warren, K., Thompson, N., Wannemuehler, M., Kohut, M. Tags: ARTICLES Source Type: research

Calpain and caspase-3 play required roles in immobilization-induced limb muscle atrophy
Prolonged skeletal muscle inactivity results in a rapid decrease in fiber size, primarily due to accelerated proteolysis. Although several proteases are known to contribute to disuse muscle atrophy, the ubiquitin proteasome system is often considered the most important proteolytic system during many conditions that promote muscle wasting. Emerging evidence suggests that calpain and caspase-3 may also play key roles in inactivity-induced atrophy of respiratory muscles, but it remains unknown if these proteases are essential for disuse atrophy in limb skeletal muscles. Therefore, we tested the hypothesis that activation of b...
Source: Journal of Applied Physiology - May 16, 2013 Category: Physiology Authors: Talbert, E. E., Smuder, A. J., Min, K., Kwon, O. S., Powers, S. K. Tags: ARTICLES Source Type: research

Early and long-term results of pectoralis muscle flap reconstruction versus sternal rewiring following failed sternal closure [THORACIC]
CONCLUSIONS In our study, muscle flap reconstruction guaranteed better early and late-term results as shown by lower rates of mortality, procedure failure and hemisternum stability. Moreover, Group 1 patients had greater postoperative VC, lower NYHA class and better quality of life. These results suggest that, in patients with multiple bone fracture, the rewiring approach does not promote physiological bone consolidation, whereas the muscle flap reconstruction can assure more physiological ventilatory dynamics. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - May 16, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Zeitani, J., Pompeo, E., Nardi, P., Sergiacomi, G., Scognamiglio, M., Chiariello, G., Del Giudice, C., Arganini, C., Simonetti, G., Chiariello, L. Tags: THORACIC Source Type: research

Early and late outcome after surgical treatment of acquired non-malignant tracheo-oesophageal fistulae [THORACIC]
CONCLUSIONS Surgical treatment of TOF is associated with good results in terms of control of acute symptoms and long-term outcome, particularly concerning oral intake and spontaneous breathing. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - May 16, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Marulli, G., Loizzi, M., Cardillo, G., Battistella, L., De Palma, A., Ialongo, P., Zampieri, D., Rea, F. Tags: THORACIC Source Type: research

The utility of surgical lung biopsy in cancer patients with acute respiratory distress syndrome
Conclusions: In selected critically ill cancer patients with ARDS, SLB had a high diagnostic yield rate and an acceptable surgical complication rate. (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - May 16, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Chih-Hao ChangKuo-Chin KaoHan-Chung HuChen-Yiu HungLi-Fu LiChing-Yang WuChih-Wei WangJui-Ying FuChung-Chi HuangNing-Hung ChenCheng-Ta YangYing-Huang Tsai Source Type: research

The development of Pediatric Critical Care Medicine at The Children's Hospital of Philadelphia: an interview with Dr. John J. ‘Jack’ Downes
Summary Dr. John J. ‘Jack’ Downes (1930–), the anesthesiologist‐in‐chief at The Children's Hospital of Philadelphia (1972–1996), has made numerous contributions to pediatric anesthesia and critical care medicine through a broad spectrum of research on chronic respiratory failure, status asthmaticus, postoperative risks of apnea in premature infants, and home‐assisted mechanical ventilation. However, his defining moment was in January 1967, when The Children's Hospital of Philadelphia inaugurated its pediatric intensive care unit—the first of its kind in North America. During his tenure, he and his colleague...
Source: Pediatric Anesthesia - May 16, 2013 Category: Anesthesiology Authors: Christine L. Mai, Mark S. Schreiner, Paul G. Firth, Myron Yaster Tags: History of Pediatric Anesthesia Timeline Source Type: research

Prevalences of asthma and rhinitis among adolescents in the city of Fortaleza, Brazil: temporal changes
CONCLUSIONS: Our data show that the prevalences of asthma and rhinitis symptoms remain high among females and private school students. (Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - May 15, 2013 Category: Respiratory Medicine Source Type: research

Tomographic and functional findings in severe COPD: comparison between the wood smoke-related and smoking-related disease
CONCLUSIONES: En pacientes con EPOC-L severa no hay enfisema en la TCAR. El hallazgo más importante es el compromiso severo de la vía aérea. La disminución de la DLCO y del VA con DLCO/VA normal es probablemente determinada por la obstrucción bronquial severa y la mezcla incompleta del gas inspirado en la maniobra de la respiración única de la prueba de difusión.OBJECTIVE: Wood smoke exposure is a risk factor for COPD. For a given degree of airway obstruction, the reduction in DLCO is smaller in individuals with wood smoke-related COPD than in those with smoking-related COPD, suggesting that there is less emphysema...
Source: Jornal Brasileiro de Pneumologia - May 15, 2013 Category: Respiratory Medicine Source Type: research

Materials in Some Household Products Tied to Lung Damage
Breathing in 'nanomaterials' seems to cause inflammation, study contends (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 15, 2013 Category: Respiratory Medicine Authors: webmaster at doctorslounge.com Tags: Family Medicine, Pulmonology, Rheumatology, Preventive Medicine, News, Source Type: news

‘Obesity paradox’ holds true in COPD
Obese patients with chronic obstructive pulmonary disease are significantly less likely to die in hospital, or to be readmitted following an exacerbation than normal weight patients, show the results of Spanish research. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - May 15, 2013 Category: Respiratory Medicine Source Type: news