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This page shows you the most recent publications within this specialty of the MedWorm directory.

Index
(Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - May 25, 2013 Category: Respiratory Medicine Source Type: research

Contributors
(Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - May 25, 2013 Category: Respiratory Medicine Source Type: research

Contents
(Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - May 25, 2013 Category: Respiratory Medicine Source Type: research

Forthcoming Issues
(Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - May 25, 2013 Category: Respiratory Medicine Source Type: research

Preface
Recent global estimates indicate that approximately 34 million people are living with HIV infection. A disproportionate number live in low and middle income countries. Many HIV-infected persons residing in these resource-limited regions experience serious or fatal lung complications. HIV-associated lung complications are also frequent causes of illness and death in industrialized, higher income nations, where the greatly improved prognosis due to more widespread availability and access to combination antiretroviral therapy (ART) has turned HIV infection into a chronic disease. Among persons on ART, growing numbers are surv...
Source: Clinics in Chest Medicine - May 25, 2013 Category: Respiratory Medicine Authors: Kristina Crothers, Laurence Huang, Alison Morris Source Type: research

Toll-like receptor 8: augmentation of innate immunity in platinum resistant ovarian carcinoma
Brueseke TJ, Tewari KS (Source: International Journal of COPD)
Source: International Journal of COPD - May 25, 2013 Category: Respiratory Medicine Source Type: research

In the eye of the storm: mitochondrial damage during heart and brain ischaemia
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - May 25, 2013 Category: Research Authors: Vilmante Borutaite, Adolfas Toleikis, Guy C. Brown Tags: Review Article Source Type: research

Design, synthesis and antiviral activity of 2-(3-amino-4-piperazinylphenyl)chromone derivatives.
Abstract Previously, we have confirmed that the antiviral activities of the chromone derivatives were controlled by the type as well as the position of the substituents attached to the chromone core structure. In the course of our ongoing efforts to optimize the antiviral activity of the chromone derivatives, we have been attempting to derivatize the chromone scaffold via introduction of various substituents. In this proof-of-concept study, we introduced a 3-amino-4-piperazinylphenyl functionality to the chromone scaffold and evaluated the antiviral activities of the resulting chromone derivatives. The synthesized ...
Source: Chemical and Pharmaceutical Bulletin - May 25, 2013 Category: Drugs & Pharmacology Authors: Kim MK, Yoon H, Barnard DL, Chong Y Tags: Chem Pharm Bull (Tokyo) Source Type: research

Mediastinal Paraganglioma between the Great Vessels in an 81-Year-Old Woman.
We report the case of an 81-year-old woman who presented with neck pain, intermittent palpitations, hypertension, and dyspnea. Contrast-enhanced computed tomography of the chest revealed a multilobular, high-density lesion between the aorta and the pulmonary artery in the superior mediastinum. The patient's 24-hour urinary vanillylmandelic acid levels were not elevated, which suggested a nonfunctional tumor. Mediastinal exploration revealed a large, vascular, irregular, consistently firm mass that adhered to the aortic arch. Upon histopathologic analysis after complete resection, the mass was determined to be a paraganglio...
Source: Texas Heart Institute Journal - May 25, 2013 Category: Cardiology Authors: Ghouri MA, Krishnan E, Singh A, Zaman T, Hallman CH Tags: Tex Heart Inst J Source Type: research

"Smoking wet": respiratory failure related to smoking tainted marijuana cigarettes.
We report the cases of 2 young adults who presented at our hospital with respiratory failure soon after they had smoked "wet" marijuana cigarettes. In both patients, progressive hypoxemic respiratory failure necessitated rescue therapy with extracorporeal membrane oxygenation. After lengthy hospitalizations, both patients recovered with only mild pulmonary function abnormalities. To our knowledge, this is the first 2-patient report of severe respiratory failure and rescue therapy with extracorporeal oxygenation after the smoking of marijuana cigarettes thus tainted. We believe that, in young adults with an unexplained pres...
Source: Texas Heart Institute Journal - May 25, 2013 Category: Cardiology Authors: Gilbert CR, Baram M, Cavarocchi NC Tags: Tex Heart Inst J Source Type: research

Abstracts from The Aerosol Society Drug Delivery to the Lungs 23; Edinburgh International Conference Centre; Edinburgh, Scotland, UK; December 5–7, 2012
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - May 24, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Links between growth hormone and aging.
Abstract Studies in mutant, gene knock-out and transgenic mice have demonstrated that growth hormone (GH) signalling has a major impact on ageing and longevity. Growth hormone-resistant and GH-deficient animals live much longer than their normal siblings, while transgenic mice overexpressing GH are short lived. Actions of GH in juvenile animals appear to be particularly important for life extension and responsible for various phenotypic characteristics of long-lived hypopituitary mutants. Available evidence indicates that reduced GH signalling is linked to extended longevity by multiple interacting mechanisms inclu...
Source: Endokrynologia Polska - May 24, 2013 Category: Endocrinology Authors: Bartke A, Westbrook R, Sun L, Ratajczak M Tags: Endokrynol Pol Source Type: research

Erratum
In the article “ASPMN Survey—Nurses’ Practice Patterns Related to Monitoring and Preventing Respiratory Depression” by Joyce S. Willens, Carla R. Jungquist, Abigail Cohen, and Rosemary Polomano in the March 2013 issue of Pain Management Nursing (2013;14:60-65; doi: 10.1016/j.pmn.2013.01.002,) the last name for the second author was misspelled as “Junquist”. It should read as “Carla R. Jungquist”. (Source: Pain Management Nursing)
Source: Pain Management Nursing - May 24, 2013 Category: Nursing Tags: Erratum Source Type: research

Exercise capacity in early and late adult heart transplant recipients.
CONCLUSIONS: Exercise capacity did not show difference between early and late heart transplant recipients. HR reserve was higher in late compared to early recipients. HR reserve only correlated with peak VO2 in early recipients. Moreover, only late heart transplant recipients showed decrease in HR during the recovery period of cardiopulmonary exercise test. PMID: 23558876 [PubMed - in process] (Source: Cardiology Journal)
Source: Cardiology Journal - May 24, 2013 Category: Cardiology Authors: Carvalho VO, Barni C, Teixeira-Neto IS, Guimaraes GV, Carvalho VO, Bocchi EA Tags: Cardiol J Source Type: research

IL-4 gene polymorphisms and their association with atopic asthma and allergic rhinitis in Pakistani patients.
CONCLUSIONS: rs2243250 and rs2227284 are significantly associated with asthma and allergic rhinitis. The results of this study indicate that in addition to environmental factors, genetic risk factors also play an important role in the development of atopic respiratory diseases. PMID: 23654077 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)
Source: Journal of Investigational Allergology and Clinical Immunology - May 24, 2013 Category: Allergy & Immunology Authors: Micheal S, Minhas K, Ishaque M, Ahmed F, Ahmed A Tags: J Investig Allergol Clin Immunol Source Type: research

Differences in the behavior of advanced glycation end products and advanced oxidation protein products in patients with allergic rhinitis.
CONCLUSIONS: Formation of AGEs and AOPPs may be accelerated in immunological and respiratory disorders such as asthma. Depending on the marker evaluated, the presence or absence of oxidative stress in allergic rhinitis is controversial. To our knowledge, this is the first study showing the possible involvement of AGEs in allergic rhinitis. The different behavior observed for these 2 biomarkers is very likely due to the activation of specific related biochemical pathways (eg, the myeloperoxidase pathway) associated with the condition under study. PMID: 23654076 [PubMed - in process] (Source: Journal of Investigational A...
Source: Journal of Investigational Allergology and Clinical Immunology - May 24, 2013 Category: Allergy & Immunology Authors: Di Lorenzo G, Minciullo PL, Leto-Barone MS, La Piana S, La Porta G, Saija A, Gangemi S Tags: J Investig Allergol Clin Immunol Source Type: research

The clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction (Lf/IgF) for the common cold: A double blind randomized study.
CONCLUSIONS: These findings demonstrate that the Lf/IgF combination significantly decreased the incidence of colds and the cumulative number of cold-related symptoms over placebo. This therapeutic combination may be indicated for the prevention of colds and its most common symptoms in the general population when administered as a preventative supplement. PMID: 23642947 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - May 24, 2013 Category: Complementary Medicine Authors: Vitetta L, Coulson S, Beck SL, Gramotnev H, Du S, Lewis S Tags: Complement Ther Med Source Type: research

Saudis say Dutch patent on MERS virus hampers research
Testing for Middle Eastern Respiratory Syndrome has been frustrated, the Saudis say, by a patent granted to the Dutch discoverers of the new coronavirus (Source: New Scientist - Health)
Source: New Scientist - Health - May 24, 2013 Category: Consumer Health News Source Type: research

The STBUR questionnaire for predicting perioperative respiratory adverse events in children at risk for sleep-disordered breathing.
CONCLUSIONS: Children presenting for surgery with symptoms consistent with SDB may be at risk for PRAE. It is important therefore that anesthesia providers identify these individuals prior to surgery to avoid potential complications. The STBUR questionnaire appears promising as a simple, clinically useful tool for identifying children at risk for PRAE. Further studies to validate the STBUR questionnaire as a diagnostic tool may be warranted. PMID: 23551934 [PubMed - in process] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - May 24, 2013 Category: Anesthesiology Authors: Tait AR, Voepel-Lewis T, Christensen R, O'Brien LM Tags: Paediatr Anaesth Source Type: research

Pediatric cardiopulmonary arrest in the postanesthesia care unit: analysis of data from the American Heart Association Get With The Guidelines(®) -Resuscitation registry.
CONCLUSIONS: This study identified similar risk factors and underlying causes as described in previous reports of pediatric perioperative CPA, with higher mortality following a cardiac/hemodynamic cause. PMID: 23551906 [PubMed - in process] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - May 24, 2013 Category: Anesthesiology Authors: Christensen R, Voepel-Lewis T, Lewis I, Ramachandran SK, Malviya S, American Heart Association's Get With The Guidelines®-Resuscitation (formerly the National Registry of Cardiopulmonary Resuscitation) investigators Tags: Paediatr Anaesth Source Type: research

Comparison of topical tramadol and ketamine in pain treatment after tonsillectomy.
CONCLUSION: Topical tramadol and ketamine seem to be safe, effective, and easy analgesic approach for decreasing tonsillectomy pain. PMID: 23521170 [PubMed - in process] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - May 24, 2013 Category: Anesthesiology Authors: Tekelioglu UY, Apuhan T, Akkaya A, Demirhan A, Yildiz I, Simsek T, Gok U, Kocoglu H Tags: Paediatr Anaesth Source Type: research

Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children.
CONCLUSION: This systematic review supports addition of NSAIDs and/or paracetamol to systemic opioid for perioperative pain management in children. PMID: 23570544 [PubMed - in process] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - May 24, 2013 Category: Anesthesiology Authors: Wong I, St John-Green C, Walker SM Tags: Paediatr Anaesth Source Type: research

SmLMWPTP, a teleost low molecular weight protein tyrosine phosphatase, inhibits the immune response of peripheral blood leukocytes in a manner that depends on the conserved P-loop.
In this study, we identified a LMWPTP from turbot (Scophthalmus maximus) and examined its biological activity and functionality. The turbot LMWPTP (SmLMWPTP) is composed of 158 residues and possesses a typical P-loop sequence in the form of (12)VCLGNICRS(20). Purified recombinant SmLMWPTP (rSmLMWPTP) exhibited apparent phosphatase activity, which was optimal at pH 5 and 50°C. The activity of SmLMWPTP was abolished when C13 and, in particular, R19 of the P-loop were mutated. SmLMWPTP expression was detected in a wide range of tissues and upregulated by bacterial and viral infection. Subcellular localization analysis showed...
Source: Developmental and Comparative Immunology - May 24, 2013 Category: Allergy & Immunology Authors: Zhang J, Chen L, Sun L Tags: Dev Comp Immunol Source Type: research

Current devices for pediatric extracorporeal life support and mechanical circulatory support systems in the United States.
Abstract Extracorporeal life support (ECLS) and mechanical circulatory support (MCS) have become indispensable treatment tools for pediatric patients with congenital heart defects undergoing peri-operative or end-stage heart and/or lung failure. ECLS and MCS can serve as bridges to recovery, transplantation (heart or lung), destination therapy, or "bridge to bridge" long-term MCS. Dependent on patient condition, venoarterial ECMO (V-A ECMO) for heart and lung support, venovenous ECMO (V-V ECMO) for respiratory support, and MCS for uni- and biventricular support can be selected properly. Considering small patient bo...
Source: Bio-Medical Materials and Engineering - May 24, 2013 Category: Materials Science Authors: Undar A, Wang S Tags: Biomed Mater Eng Source Type: research

Corrigendum to “Systematic review of intralesional Cidofovir dosing regimens in the treatment of recurrent respiratory papillomatosis” [Int. J. Pediatr. Otorhinolaryngol. 77 (2013) 323–328]
The publisher regrets that a reference cited in the above article did not include full citation details in the reference list. The publisher would like to apologise for any inconvenience caused, and the correct reference appears below: (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - May 24, 2013 Category: ENT & OMF Authors: Philip J. Clamp, Michael W. Saunders Tags: Corrigendum Source Type: research

Referrals for recurrent respiratory tract infections including otitis media in young children
Abstract: Objective: (a) To establish whether disease-related, child-related, and physician-related factors are independently associated with specialist referral in young children with recurrent RTI, and (b) to evaluate whether general practitioners (GPs) follow current guidelines regarding these referrals.Methods: Electronic GP records of children under 24month of age, born 2002–2008, were reviewed for RTI episodes using ICPC codes. Child-related factors were extracted from the prospective WHISTLER birth-cohort in which a considerable part of children had been enrolled. To evaluate guideline adherence, referral data wer...
Source: International Journal of Pediatric Otorhinolaryngology - May 24, 2013 Category: ENT & OMF Authors: Alma C. van de Pol, Anne C. van der Gugten, Cornelis K. van der Ent, Anne G.M. Schilder, Elsje M. Benthem, Henriette A. Smit, Rebecca K. Stellato, Niek J. de Wit, Roger A. Damoiseaux Tags: Research papers Source Type: research

Airway morphology from high resolution computed tomography in healthy subjects and patients with moderate persistent asthma.
In this study, a commercial software package was used to segment the airway tree of seven healthy and six moderately persistent asthmatic patients from high resolution computed tomography images. The process was assessed with regards to the treatment of the images of the asthmatic group. The in vivo results for the bronchial length, diameter, WT, branching, and rotation angles are reported and compared per generation for different lobes. Furthermore, some popular mathematical relationships between these morphometric characteristics were examined in order to verify their validity for both groups. Our results suggest that, e...
Source: Anatomical Record - May 24, 2013 Category: Anatomy Authors: Montesantos S, Katz I, Fleming J, Majoral C, Pichelin M, Dubau C, Piednoir B, Conway J, Texereau J, Caillibotte G Tags: Anat Rec (Hoboken) Source Type: research

Cellular and molecular biology of airway mucins.
Abstract Airway mucus constitutes a thin layer of airway surface liquid with component macromolecules that covers the luminal surface of the respiratory tract. The major function of mucus is to protect the lungs through mucociliary clearance of inhaled foreign particles and noxious chemicals. Mucus is comprised of water, ions, mucin glycoproteins, and a variety of other macromolecules, some of which possess anti-microbial, anti-protease, and anti-oxidant activities. Mucins comprise the major protein component of mucus and exist as secreted and cell-associated glycoproteins. Secreted, gel-forming mucins are mainly r...
Source: International Review of Cell and Molecular Biology - May 24, 2013 Category: Cytology Authors: Lillehoj EP, Kato K, Lu W, Kim KC Tags: Int Rev Cell Mol Biol Source Type: research

Patient and carer experience of obtaining regular prescribed medication for chronic disease in the English National Health Service: a qualitative study
Conclusion: Much literature exists around medication waste and cost, which led to encouragement from the NHS in England to reduce dosage units to a 28-day supply. While there has been an acknowledgement that longer supplies may be suitable for people with stable chronic conditions, it appears that there is limited evidence on the impact of shorter length prescriptions on patient and carer experience, adherence and health outcomes. Recent policy documents within England also fail to address possible links between patient experience,adherence and flaws within repeat prescription service delivery. (Source: BMC Health Services Research)
Source: BMC Health Services Research - May 24, 2013 Category: Journals (General) Authors: Patricia WilsonNeha KatariaElaine McNeilly Source Type: research

Rapid eye movement dependent central apnea with periodic leg movements
We present our patient who had a diagnosis of obstructive sleep apnea in another sleep center since 2003. His Auto Continuous Positive Airway Pressure (CPAP) machine was disrupted so he admitted to our center to renew his machine and for daytime sleepiness while using his machine. The polysomnography revealed central apneas ending with respiratory arousals and periodic leg movements in rapid eye movement (REM) stage. We found no cause for central apneas. The patient benefited from servo ventilator therapy. We present this case as an unusual form of central apnea with the review of the literatures. Even the patients diagnos...
Source: Annals of Indian Academy of Neurology - May 24, 2013 Category: Neurology Authors: Melike YüceegeHikmet FiratMutlu KuyucuSadIk ArdIç Source Type: research

Fast micrographia: An unusual but distinctive sign
Umaiorubahan Meenakshisundaram, CU Velmurugendran, PR PrabashAnnals of Indian Academy of Neurology 2013 16(2):172-173Fast micrographia is a rare clinical sign, which is reported in patients with pallidal pathology. A 68-year-old male presented with hypophonia and short shuffling gait with decreased arm swing. About 3 weeks before, he had an acute myocardial infarction and a period of hemodynamic and respiratory distress during which he required mechanical ventilatory support. He was found to have a fast handwriting with micrographia from the outset. His rapid alternating hand and finger movements were normal. Magnetic reso...
Source: Annals of Indian Academy of Neurology - May 24, 2013 Category: Neurology Authors: Umaiorubahan MeenakshisundaramCU VelmurugendranPR Prabash Source Type: research

Clinical and biochemical spectrum of hypokalemic paralysis in North: East India
Conclusion: A high percentage (42.9%) of secondary cause for hypokalemic paralysis warrants that the underlying cause must be adequately addressed to prevent the persistence or recurrence of paralysis. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - May 24, 2013 Category: Neurology Authors: Ashok K KayalMunindra GoswamiMarami DasRahul Jain Source Type: research

Management of intratonsillar abscess in children
ConclusionsClinically stable children with intratonsillar abscess or phlegmon respond to trial of intravenous antibiotic therapy. Surgical drainage can accomplish clinical resolution in the presence of combination of intra‐ and peri‐tonsillar abscess, airway compromise, or unresponsiveness to medical treatment. (Source: Pediatrics International)
Source: Pediatrics International - May 24, 2013 Category: Pediatrics Authors: Seckin O. Ulualp, Korgun Koral, Linda Margraf, Ronald Deskin Tags: Original Article Source Type: research

Clinical and genetic analysis of a Korean patient with X-linked chondrodysplasia punctata: identification of a novel splicing mutation in the ARSE gene.
This report expands the spectrum of mutations of the ARSE gene and, to the best of our knowledge, is the first clinically and genetically confirmed case of CDPX1 with severe spinal cord compression in Korea. PMID: 23462608 [PubMed - in process] (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - May 23, 2013 Category: Laboratory Medicine Authors: Jeon GW, Kwon MJ, Lee SJ, Sin JB, Ki CS Tags: Ann Clin Lab Sci Source Type: research

Spondylocostal dysostosis associated with type I split cord malformation and double nipple on one side: a case report.
We present a patient with spondylocostal dysostosis, who also had type I split cord malformation, tethered cord, scoliosis and double nipple on the right. Although the association of spondylocostal dysostosis and type I split cord malformation is very rare, double nipples on one side is no previously reported. PMID: 23546915 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - May 23, 2013 Category: Neurosurgery Authors: Yilmaz MB, Kaymak A, Kurt G, Percin FE, Baykaner K Tags: Turk Neurosurg Source Type: research

Pulmonary Manifestations of Collagen Diseases.
The objective of this article is to offer a global vision of how collagen diseases can affect the lungs according to the latest scientific evidence. PMID: 23683373 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - May 23, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Gómez Carrera L, Bonilla Hernan G Tags: Arch Bronconeumol Source Type: research

Asynchrony and Hyperinflation in Patients With Chronic Obstructive Pulmonary Disease During Two Types of Upper Limbs Exercise.
CONCLUSIONS: Dynamic pulmonary hyperinflation and thoracoabdominal asynchrony association occurred in both upper-limbs exercises; however, the diagonal technique developed less dynamic hyperinflation and thoracoabdominal asynchrony in COPD patients than the arm cycle ergometer. PMID: 23518289 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - May 23, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Castro AA, Porto EF, Feltrim MI, Jardim JR Tags: Arch Bronconeumol Source Type: research

Efficacy and safety of spontaneous ventilation technique using dexmedetomidine for rigid bronchoscopic airway foreign body removal in children
ConclusionDexmedetomidine may provide appropriately deep anesthesia and ideal conditions for rigid bronchoscopic airway foreign body removal without respiratory depression or hemodynamic instability. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - May 23, 2013 Category: Anesthesiology Authors: Yirong Cai, Wenxian Li, Kaizheng Chen Tags: Original Article Source Type: research

Role of N-linked glycosylation of the human parainfluenza virus type 3 hemagglutinin-neuraminidase protein.
Abstract Human parainfluenza virus type 3 (hPIV-3) is a major respiratory tract pathogen that affects infants and young children. The hPIV-3 hemagglutinin-neuraminidase (HN) protein is a multifunctional protein mediating hemadsorption (HAD), neuraminidase (NA), and fusion promotion activities, each of which affects the ability of HN to promote viral fusion and entry. The hPIV-3 HN protein contains four potential sites (N308, N351, N485 and N523) for N-linked glycosylation. Electrophoretic mobility analysis of mutated HN proteins indicated that N308, N351 and N523 sites, but not the N485 site in HN protein, were tar...
Source: Virus Research - May 23, 2013 Category: Virology Authors: Chu FL, Wen HL, Hou GH, Lin B, Zhang WQ, Song YY, Ren GJ, Sun CX, Li ZM, Wang Z Tags: Virus Res Source Type: research

Litorimonas cladophorae sp. nov., a new alphaproteobacterium isolated from the Pacific green alga Cladophora stimpsoni, and emended descriptions of the genus Litorimonas and Litorimonas taeaensis.
Abstract A strictly aerobic, Gram-stain-negative, rod-shaped and red-orange pigmented bacterium, designated strain KMM 6395(T), was isolated from the green alga Cladophora stimpsoni and subjected to a polyphasic taxonomic study. Phylogenetic analysis based on 16S rRNA gene sequencing revealed that the novel strain affiliated to the family Hyphomonadaceae of the class Alphaproteobacteria being most closely related to the type strain of the single species of the genus Litorimonas, Litorimonas taeanensis G5(T), with 16S rRNA gene sequence similarity of 96.8 %. Strain KMM 6395(T) grew with 1-5 % NaCl and at 4-35 °C...
Source: Antonie van Leeuwenhoek - May 23, 2013 Category: Microbiology Authors: Nedashkovskaya OI, Kukhlevskiy AD, Zhukova NV, Kim SJ, Rhee SK Tags: Antonie Van Leeuwenhoek Source Type: research

Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror.
Abstract Epithelial tubes are the infrastructure for organs and tissues, and tube morphogenesis requires precise orchestration of cell signaling, shape, migration, and adhesion. Follicle cells in the Drosophila ovary form a pair of epithelial tubes whose lumens act as molds for the eggshell respiratory filaments, or dorsal appendages (DAs). DA formation is a robust and accessible model for studying the patterning, formation, and expansion of epithelial tubes. Tramtrack69 (TTK69), a transcription factor that exhibits a variable embryonic DNA-binding preference, controls DA lumen volume and shape by promoting tube ex...
Source: Developmental Biology - May 23, 2013 Category: Biology Authors: Peters NC, Thayer NH, Kerr SA, Tompa M, Berg CA Tags: Dev Biol Source Type: research

Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells.
In this study, we show that Fzd7 is required to transduce a low level of Wnt signaling that is essential to maintain foregut progenitors. Foregut-specific Fzd7-depletion from the Xenopus foregut resulted in liver and pancreas agenesis. Fzd7-depleted embryos failed to maintain the foregut progenitor marker hhex and exhibited decreased proliferation; in addition the foregut cells were enlarged with a randomized orientation. We show that in the foregut Fzd7 signals via both the Wnt/β-catenin and Wnt/JNK pathways and that different thresholds of Wnt-Fzd7 activity coordinate progenitor cell fate, proliferation and morphogenesi...
Source: Developmental Biology - May 23, 2013 Category: Biology Authors: Zhang Z, Rankin SA, Zorn AM Tags: Dev Biol Source Type: research

Effects of treatment in the levels of circulating cytokines and growth factors in cystic fibrosis and dialyzed patients by multi-analytical determination with a biochip array platform.
In this study, we used a biochip array system capable of measuring 12 cytokines and growth factors (IL-2, IL-4, IL-6, IL-8, IL-10, IL-1 α, IL-1 β, IFN-γ, TNF-α, MCP-1, VEGF, and EGF) in three groups: 97 control subjects; 24 cystic fibrosis (CF) patients before and during the antibiotic treatment (6 and 15days) for acute pulmonary exacerbation as well as 15days after the withdrawal of therapy; 22 children and young adults on chronic hemodialysis (HD) at the beginning and at the end of a standard HD session. CF patients in acute exacerbation displayed higher IL-2, IL-6, VEGF and MCP-1 levels than the control subjects. IL...
Source: Cytokine - May 23, 2013 Category: Molecular Biology Authors: Tirelli AS, Colombo C, Torresani E, Fortunato F, Biffi A, Cariani L, Daccò V, Carbone A, Edefonti A, Paglialonga F, Conese M Tags: Cytokine Source Type: research

Effects of hibernation on regulation of mammalian protein phosphatase type-2-A.
Abstract Hibernation is used by many small mammals for winter survival. Animals undergo cycles of deep torpor characterized by strong reductions in metabolic rate, body temperature, and all physiological activities. One prominent biochemical mechanism involved in regulating coordinated transitions to and from the hypometabolic state is reversible protein phosphorylation, a dynamic covalent modification maintained by the actions of protein kinases and protein phosphatases. The present study characterizes protein phosphatase type 2A (PP2A) from liver and skeletal muscle of Richardson's ground squirrels, Urocitellus r...
Source: Cryobiology - May 23, 2013 Category: Biology Authors: Wu CW, Reardon AJ, Storey KB Tags: Cryobiology Source Type: research

September through October 2010 multi-centre study in the Netherlands examining laboratory ability to detect enterovirus 68, an emerging respiratory pathogen.
Abstract During September and October 2010, the Dutch Public Health Institute detected an enterovirus (EV) 68 (EV68) epidemic in the Netherlands through general practitioner-based surveillance of acute respiratory infections. EV68 shares phenotypic and genotypic properties with human rhinovirus (HRV). Despite increased EV and HRV detections, Dutch clinical laboratories did not identify EV68. To assess the capability of Dutch clinical laboratories to detect EV68, ten laboratories with more than eight detected EV and HRV cases in September and October 2010 provided information about their detection algorithms and tes...
Source: Journal of Virological Methods - May 23, 2013 Category: Virology Authors: Jaramillo-Gutierrez G, Benschop KS, Claas EC, de Jong AS, van Loon AM, Pas SD, Pontesilli O, Rossen JW, Swanink CM, Thijsen S, van der Zanden AG, van der Avoort HG, Koopmans MP, Meijer A Tags: J Virol Methods Source Type: research

The use of sialidase therapy for respiratory viral infections.
Abstract DAS181 is an inhaled bacterial sialidase which functions by removing sialic acid (Sia) from the surface of epithelial cells, preventing attachment and subsequent infection by respiratory viruses that utilize Sia as a receptor. DAS181 is typical of bacterial sialidases in cleaving Sia α2-3 and Sia α2-6 linkages, and it also has a demonstrated effect against acetylated and hydroxylated forms of Sia. The potency of the compound has been enhanced by coupling the active sialidase with an amphiregulin tag, allowing a longer duration of action and minimizing spread to the systemic circulation. DAS181 is now in ...
Source: Antiviral Research - May 23, 2013 Category: Virology Authors: Nicholls JM, Moss RB, Haslam SM Tags: Antiviral Res Source Type: research

Immunomodulaton and attenuation of lethal influenza A virus infection by oral administration with KIOM-C.
In this study, we investigated the antiviral effect of KIOM-C for the treatment of influenza A virus infection. Our results show that oral administration of KIOM-C conferred a survival benefit to mice infected with the 2009 pandemic H1N1 [A(H1N1)pdm09] virus, and resulted in a 10- to 100-fold attenuation of viral replication in ferrets in a dose-dependent manner. Additionally, oral administration of KIOM-C increased the production of antiviral cytokines, including IFN-γ and TNF-α, and decreased levels of pro-inflammatory cytokines (IL-6) and chemokines (KC, MCP-1) in the Bronchoalveolar lavage fluid (BALF) of A(H1N1)pdm-...
Source: Antiviral Research - May 23, 2013 Category: Virology Authors: Kim EH, Pascua PN, Song MS, Baek YH, Kwon HI, Park SJ, Lim GJ, Kim SM, Decano A, Lee KJ, Cho WK, Ma JY, Choi YK Tags: Antiviral Res Source Type: research

Late acyltransferase genes lpxX and lpxL jointly contribute to the biological activities of Moraxella catarrhalis.
In this study, a double mutant with a deletion of both the lpxX and lpxL genes in M. catarrhalis strain O35E was constructed and named O35ElpxXL. Structural analysis of lipid A showed that the O35ElpxXL mutant lacked two decanoic acids (10 : 0) and one dodecanoic (lauric) acid (12 : 0). In comparison with the O35E parental strain and the single mutants O35ElpxX and O35ElpxL, the double mutant O35ElpxXL displayed prominently decreased endotoxin content, reduced resistance to normal human serum and accelerated bacterial clearance at 0, 3 and 6 h after an aerosol challenge in a mouse model of bacterial pulmonary clear...
Source: Journal of Medical Microbiology - May 23, 2013 Category: Microbiology Authors: Gao S, Ren D, Peng D, Zhang W, Muszynski A, Carlson RW, Gu XX Tags: J Med Microbiol Source Type: research

The use of non-invasive ventilation at end of life in patients with motor neurone disease: A qualitative exploration of family carer and health professional experiences.
Conclusions: The use of non-invasive ventilation was described as beneficial and was not perceived by carers or most professionals to have adversely impacted patient's end-of-life experience. This study highlights variation in patient wishes regarding usage towards the end of life, uncertainty regarding appropriate management among professionals and the importance of disseminating end-of-life wishes. PMID: 23462702 [PubMed - in process] (Source: Palliative Medicine)
Source: Palliative Medicine - May 23, 2013 Category: Palliative Care Authors: Baxter SK, Baird WO, Thompson S, Bianchi SM, Walters SJ, Lee E, Ahmedzai SH, Proctor A, Shaw PJ, McDermott CJ Tags: Palliat Med Source Type: research