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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Chlamydia felis: Lack of association between clinical signs and the presence of the cryptic plasmid
Publication date: August 2016 Source:Microbial Pathogenesis, Volume 97 Author(s): F.F. Gonsales, P.E. Brandão, P.A. Melville, E. Zuniga, N.R. Benites Chlamydia felis is an obligate intracellular bacterial pathogen that infects cats, causing severe conjunctivitis associated with upper respiratory tract disease (URTD). In the present study, 186 cats from three non-commercial catteries in São Paulo, SP, Brazil were evaluated. The detection of Chlamydia felis was performed by PCR. The clinical severity was scored from 1 to 4, with a score of 4 as the most severe manifestation. The total occurrence of C. felis was of ...
Source: Microbial Pathogenesis - June 16, 2016 Category: Infectious Diseases Source Type: research

Emerging of two new subgenotypes of porcine reproductive and respiratory syndrome viruses in Southeast China
In this study, a total of 49 PRRSV isolates were collected from different swine herds in seven provinces in Southeast China from 2014 to 2015. All the ORF5 genes and some Nsp2 genes were sequenced. Phylogenetic analysis showed that all the isolates belonged to the North America genotype. Among them, five isolates formed a new subgenotype IV derived from highly pathogenic PRRSV (HP-PRRSV). Six isolates formed subgenotype III, which were closely related to the NADC30 strain in the US. These isolates formed 13 putative N-linked glycosylation site (NGS) patterns based on N30, 33, 34, 35, 44 and 51. There were fewer NGSs of iso...
Source: Microbial Pathogenesis - June 16, 2016 Category: Infectious Diseases Source Type: research

Automated, continuous and non-invasive assessment of pulse pressure variations using CNAP ® system
Abstract Non-invasive respiratory variations in arterial pulse pressure using infrared-plethysmography (PPVCNAP) are able to predict fluid responsiveness in mechanically ventilated patients. However, they cannot be continuously monitored. The present study evaluated a new algorithm allowing continuous measurements of PPVCNAP (PPVCNAPauto) (CNSystem, Graz, Austria). Thirty-five patients undergoing vascular surgery were studied after induction of general anaesthesia. Stroke volume was measured using the VigileoTM/FloTracTM. Invasive pulse pressure variations were manually calculated using an arterial line (PPVART) a...
Source: Journal of Clinical Monitoring and Computing - June 16, 2016 Category: Information Technology Source Type: research

Treatment difficulties of malignant esophagorespiratory fistula: Case report of a 56-year-old patient with esophageal cancer
Conclusions An immediate implementation of diagnostic and therapeutic methods is necessary, as the time to diagnosis and treatment of a malignant fistula strongly influences the patient's survival and quality of life. (Source: Polish Annals of Medicine)
Source: Polish Annals of Medicine - June 16, 2016 Category: Journals (General) Source Type: research

Role of phrenic nerve in respiratory distress secondary to Lyme neuroborreliosis
Conclusion This paper reviews the literature pertaining to the importance of the phrenic nerve in Lyme disease. (Source: Polish Annals of Medicine)
Source: Polish Annals of Medicine - June 16, 2016 Category: Journals (General) Source Type: research

Extrafine beclometasone diproprionate/formoterol fumarate: a review of its effects in chronic obstructive pulmonary disease
npj Primary Care Respiratory Medicine, Published online: 16 June 2016; doi:10.1038/npjpcrm.2016.30 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - June 16, 2016 Category: Primary Care Authors: Dave SinghMassimo CorradiMonica SpinolaStefano PetruzzelliAlberto Papi Source Type: research

A tree-matching algorithm: Application to airways in CT images of subjects with the acute respiratory distress syndrome
The matching of 3D anatomic tree structures has been studied for various applications, mainly in the vascular and bronchial research fields. Most of these applications can be classified into one of the following two categories (Kaftan et al., 2006; Feragen et al., 2015): intersubject or intrasubject. In the former category, the goal generally is to automatically label a set of predefined anatomical landmarks (branches or bifurcations), despite possibly significant geometrical (and some topological) differences due to intersubject anatomical variability. (Source: Medical Image Analysis)
Source: Medical Image Analysis - June 16, 2016 Category: Radiology Authors: Alfredo Morales Pinzón, Marcela Hernández Hoyos, Jean-Christophe Richard, Leonardo Flórez-Valencia, Maciej Orkisz Source Type: research

Editorial Board, Masthead, TOC
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - June 16, 2016 Category: Respiratory Medicine Tags: Issue Information Source Type: research

Upcoming events of interest
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - June 16, 2016 Category: Respiratory Medicine Tags: Upcoming Events Source Type: research

Novel approaches to preclinical research and TB vaccine development
Preclinical investigations, particularly challenge studies in small animal species such as mice and guinea pigs, often ultimately leading to challenge studies in non-human primates (NHPs), represent a critical step in the development of many vaccines. This is particularly true when developing vaccines for tuberculosis (TB) due to the lack in our understanding of the correlates of immunological protection against either TB disease, or infection with Mycobacterium tuberculosis (Mtb), which might otherwise guide the vaccine development process. (Source: Tuberculosis)
Source: Tuberculosis - June 16, 2016 Category: Respiratory Medicine Authors: Kenneth Barry Walker, Ming Guo, Yan Guo, Johanna Poecheim, Kamalakannan Velmurugan, Lewis K. Schrager Source Type: research

TB biomarkers, TB correlates and human challenge models: New tools for improving assessment of new TB vaccines
The canonical approach to tuberculosis (TB) vaccine development progresses from an idea based on experimental data to preclinical studies [1]. If protection is consistently observed in all relevant preclinical studies and has passed all essential gating criteria, the vaccine can be selected for entering the clinical trial pipeline. In phase 1 this focuses on obtaining safety and early immunogenicity data while in phase 2 this includes dosing, advanced immunogenicity and early efficacy studies. The failure of a novel TB vaccine candidate to demonstrate protection in a recent phase 2b efficacy trial [2, 3] has raised questio...
Source: Tuberculosis - June 16, 2016 Category: Respiratory Medicine Authors: Stefan HE. Kaufmann, Sarah Fortune, Ilaria Pepponi, Morten Ruhwald, Lewis Schrager, Tom HM. Ottenhoff Source Type: research

Advocacy, partnership and political commitment for TB vaccine research
When world leaders adopted the Millennium Declaration in September 2000, they included specific targets to halt and begin to reverse the incidence of tuberculosis (TB). The Millennium Declaration was followed by new initiatives to overcome the structural and financial obstacles for developing new TB vaccines, backed by support from public and philanthropic sources. These initiatives included the establishment of dedicated product development partnerships (PDPs) such as Aeras and the TuBerculosis Vaccine Initiative (TBVI), public-public partnerships like the European & Developing Countries Clinical Trials Partnership (EDCTP...
Source: Tuberculosis - June 16, 2016 Category: Respiratory Medicine Authors: Ole F. Olesen, Sharon Chan, Janice Chappell, Yan Guo, Luciana C.C. Leite Source Type: research

Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis
Resistance to isoniazid (INH-R) in Mycobacterium tuberculosis is mainly due to mutations at position 315 (S315T) of the catalase-peroxidase KatG. We identified 16 mutations (including 13 biochemically uncharacterized mutations) in KatG from INH-R clinical isolates of M. tuberculosis showing mutations other than S315T. The KatG enzymatic activities (catalase, peroxidase, free radical production and isonicotinoyl-NAD formation) of wild-type KatG and the 16 mutants were determined and correlated to their spatial location in a KatG model structure. (Source: Tuberculosis)
Source: Tuberculosis - June 16, 2016 Category: Respiratory Medicine Authors: Florence Brossier, Marlène Boudinet, Vincent Jarlier, Stéphanie Petrella, Wladimir Sougakoff Tags: Drug Discovery and Resistance Source Type: research

The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections
In airway infections, biofilm formation has been demonstrated to be responsible for both acute and chronic events, and constitutes a genuine challenge in clinical practice. Difficulty in eradicating biofilms with systemic antibiotics has led clinicians to consider the possible role of non-antibiotic therapy. The aim of this review is to examine current evidence for the use of N-acetylcysteine (NAC) in the treatment of biofilm-related respiratory infections. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 16, 2016 Category: Respiratory Medicine Authors: Francesco Blasi, Clive Page, Gian Maria Rossolini, Lucia Pallecchi, Maria Gabriella Matera, Paola Rogliani, Mario Cazzola Tags: Review article Source Type: research

Awareness, knowledge, healthy lifestyle behaviors, and their correlates to coronary heart disease among working women in Singapore
Conclusion Health care providers should systematically evaluate women at risk for CHD and provide both gender-sensitive and age-specific education. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - June 16, 2016 Category: Respiratory Medicine Source Type: research

Acute eosinophilic pneumonia caused by camostat mesilate: The first case report
Publication date: Available online 16 June 2016 Source:Respiratory Medicine Case Reports Author(s): Shinichiro Ota, Yu Hara, Soichiro Kanoh, Masahiro Shinoda, Shuichi Kawano, Yuji Fujikura, Akihiko Kawana, Masaharu Shinkai Camostat mesilate is in widespread clinical use mainly to treat chronic pancreatitis, and drug-induced lung injury has not been previously reported. However, pulmonary infiltration with peripheral blood eosinophilia appeared after taking camostat mesilate for ten days. The histological findings showed eosinophilic infiltration into the alveolar space and interstitum, and drug lymphocyte stimula...
Source: Respiratory Medicine Case Reports - June 16, 2016 Category: Respiratory Medicine Source Type: research

Carbamylated erythropoietin enhances mice ventilatory responses to changes in O2 but not CO2 levels
Publication date: Available online 16 June 2016 Source:Respiratory Physiology & Neurobiology Author(s): Hanan Khemiri, Marc Maresca, Christian Gestreau Erythropoietin (EPO) has beneficial tissue-protective effects in several diseases but erythrocytosis may cause deleterious effects in EPO-treated patients. Thus carbamylated-EPO (C-EPO) and other derivatives retaining tissue-protective but lacking bone marrow-stimulating actions have been developed. Although EPO modulates ventilatory responses, the effects of C-EPO on ventilation have not been investigated. Here, basal breathing and respiratory chemoreflexes we...
Source: Respiratory Physiology and Neurobiology - June 16, 2016 Category: Respiratory Medicine Source Type: research

Acute exercise amplifies inflammation in obese patients with COPD
Publication date: Available online 16 June 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): F. Rodrigues, A.L. Papoila, D. Ligeiro, M.J.M. Gomes, H. Trindade Systemic inflammation has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD) systemic effects. However, most COPD patients do not suffer from persistent systemic inflammation even after exacerbations and exercise and scientific evidence has provided conflicting results. Our aim is to evaluate inflammatory gene expression at rest and at 1 and 24h after strenuous exercise in COPD patients and study the pa...
Source: Revista Portuguesa de Pneumologia - June 16, 2016 Category: Respiratory Medicine Source Type: research

Hospital care in severe trauma: Initial strategies and life-saving surgical procedures
Publication date: Available online 31 May 2016 Source:Journal of Visceral Surgery Author(s): T. Monchal, E. Hornez, B. Prunet, S. Beaume, H. Marsaa, S. Bourgouin, Y. Baudoin, S. Bonnet, J.-B. Morvan, J.-P. Avaro, A. Dagain, J.-P. Platel, P. Balandraud Severe trauma patients should be received at the hospital by a multidisciplinary team directed by a “trauma leader” and all institutions capable of receiving such patients should be well organized. As soon as the patient is accepted for care, the entire team should be prepared so that there is no interruption in the pre-hospital chain of care. All caregiver...
Source: Journal of Visceral Surgery - June 16, 2016 Category: Surgery Source Type: research

Improving the cytoplasmic maturation of bovine oocytes matured in vitro with intra- and/or extracellular antioxidants is not associated with increased rates of embryo development
The production of reactive oxygen species (ROS) is a normal process that occurs in the cellular mitochondrial respiratory chain. However, an increase in ROS levels during in vitro production of bovine embryos induces oxidative stress, leading to failed embryonic development. Therefore, we investigated whether supplementation of IVM medium with intracellular (cysteine and cysteamine; C+C) and/or extracellular (catalase; CAT) antioxidants improves the culture system, affects the mitochondrial membrane potential, affects the intracellular levels of ROS and glutathione (GSH) in the bovine oocytes at the end of maturation, and ...
Source: Theriogenology - June 16, 2016 Category: Genetics & Stem Cells Authors: Nathália A.S. Rocha-Frigoni, Beatriz C.S. Leão, Priscila Chediek Dall’Acqua, Gisele Z. Mingoti Source Type: research

Mitochondria as a therapeutic target in Alzheimer's disease
Publication date: Available online 16 June 2016 Source:Genes & Diseases Author(s): Jian Wang, Guo-Jun Chen Alzheimer's disease (AD) remains the most common neurodegenerative disease characterized by β-amyloid protein (Aβ) deposition and memory loss. Studies have shown that mitochondrial dysfunction plays a crucial role in AD, which involves oxidative stress-induced respiratory chain dysfunction, loss of mitochondrial biogenesis, defects of mitochondrial dynamics and mtDNA mutations. Thus mitochondria might serve as drug therapy target for AD. In this article, we first briefly discussed mitochondrial theory in...
Source: Genes and Diseases - June 16, 2016 Category: Genetics & Stem Cells Source Type: research

Time series analysis of RSV and bronchiolitis seasonality in temperate and tropical Western Australia
We examined over 13 years of RSV laboratory identifications and bronchiolitis hospitalisations in children, using an extensive linked dataset from Western Australia. We applied mathematical time series analyses to identify the dominant seasonal cycle, and changes in epidemic size and timing over this period. Both the RSV and bronchiolitis data showed clear winter epidemic peaks in July or August in the southern Western Australia regions, but less identifiable seasonality in the northern regions. Use of complex demodulation proved very effective at comparing disease epidemics. The timing of RSV and bronchiolitis epidemics c...
Source: Epidemics - June 16, 2016 Category: Epidemiology Source Type: research

Investigating trends in asthma and COPD through multiple data sources: a small area study
Publication date: Available online 11 June 2016 Source:Spatial and Spatio-temporal Epidemiology Author(s): Areti Boulieri, Anna Hansell, Marta Blangiardo This paper investigates trends in asthma and COPD by using multiple data sources to help understanding the relationships between disease prevalence, morbidity and mortality. GP drug prescriptions, hospital admissions, and deaths are analysed at clinical commissioning group (CCG) level in England from August 2010 to March 2011. A Bayesian hierarchical model is used for the analysis, which takes into account the complex space and time dependencies of asthma and COPD, w...
Source: Spatial and Spatio-temporal Epidemiology - June 16, 2016 Category: Epidemiology Source Type: research

Prevalence of symptoms associated with respiratory illness in children and young people with cerebral palsy
(Source: Developmental Medicine and Child Neurology)
Source: Developmental Medicine and Child Neurology - June 16, 2016 Category: Child Development Authors: Amanda Marie Blackmore, Natasha Bear, Eve Blair, Noula Gibson, Caris Jalla, Katherine Langdon, Lisa Moshovis, Kellie Steer, Andrew C Wilson Tags: Letter to the Editor Source Type: research

Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection
by Anthony C. Marriott, Mike Dennis, Jennifer A. Kane, Karen E. Gooch, Graham Hatch, Sally Sharpe, Claudia Prevosto, Gail Leeming, Elsa-Gayle Zekeng, Karl J. Staples, Graham Hall, Kathryn A. Ryan, Simon Bate, Nathifa Moyo, Catherine J. Whittaker, Bassam Hallis, Nigel J. Silman, Ajit Lalvani, Tom M. Wilkinson, Julian A. Hiscox, James P. Stewart, Miles W. Carroll Non-human primates are the animals closest to humans for use in influenza A virus challenge studies, in terms of their phylogenetic relatedness, physiology and immune systems. Previous studies have shown that cynomolgus macaques (Macaca fascicularis) are permissive...
Source: PLoS One - June 16, 2016 Category: Biomedical Science Authors: Anthony C. Marriott Source Type: research

Daily nursing care on patients undergoing venous–venous extracorporeal membrane oxygenation: a challenging procedure!
Abstract Daily nursing in critical care patients may alter vital parameters, especially in the most critically ill patients. The aim of our study was to evaluate feasibility and safety of daily nursing on patients undergoing venous–venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure. Daily nursing was performed following defined phases (sponge bath, elevation with scooping stretcher, change position of endotracheal tube, dressing replacement). We recorded physiological and ECMO parameters before and during daily nursing in 5 patients for several days (total: 25 daily nursing) and ...
Source: Journal of Artificial Organs - June 16, 2016 Category: Transplant Surgery Source Type: research

Elevation of post mortem vitreous humour sodium and chloride levels can be used as a reliable test in cases of suspected salt water drowning when the immersion times are less than one hour
Drowning is the process of experiencing respiratory impairment from submersion/immersion in a liquid [1]. During drowning, large volumes of liquid may be inhaled and/or ingested, and death can occur within minutes. The mechanism of death is thought to be by asphyxiation/hypoxia [2]. Making a diagnosis of drowning can be challenging due to the absence of specific post mortem findings and unreliable ancillary tests [2]. (Source: Forensic Science International)
Source: Forensic Science International - June 16, 2016 Category: Forensic Medicine Authors: J. Garland, R. Tse, C. Oldmeadow, J. Attia, S. Anne BMed, A.D. Cala Source Type: research

Expression of RXFP1 is Decreased in Idiopathic Pulmonary Fibrosis: Implications for Relaxin-Based Therapies.
CONCLUSIONS: IPF is characterized by the loss of RXFP1 expression. RXFP1 expression is directly associated with DLCO in IPF patients. The relaxin-like effects of CGEN25009 in vitro are dependent on expression of RXFP1. Our data suggest that IPF patients with the highest RXFP1 expression would be predicted to be most sensitive to relaxin-based therapies. PMID: 27310652 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - June 16, 2016 Category: Respiratory Medicine Authors: Tan J, Tedrow JR, Dutta JA, Juan-Guardela B, Nouraie M, Chu Y, Trejo Bittar H, Ramani K, Biswas PS, Veraldi KL, Kaminski N, Zhang Y, Kass DJ Tags: Am J Respir Crit Care Med Source Type: research

Coexistence and Impact of Limb Muscle and Diaphragm Weakness at Time of Liberation From Mechanical Ventilation in Medical ICU Patients.
CONCLUSIONS: Diaphragm dysfunction is twice as frequent as limb muscle weakness and has a direct negative impact on weaning outcome. The two types of muscle weakness have only limited overlap. PMID: 27310484 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - June 16, 2016 Category: Respiratory Medicine Authors: Dres M, Dubé BP, Mayaux J, Delemazure J, Reuter D, Brochard L, Similowski T, Demoule A Tags: Am J Respir Crit Care Med Source Type: research

Only the complex N559-glycan in SV2C mediates high affinity binding to botulinum neurotoxin serotype A1.
In conclusion, we show the importance of the complex N559‑glycan of SV2C-LD4, adding a third anchor point beside a ganglioside and the SV2C-LD4 peptide, for BoNT/A neuronal cell surface binding and uptake. PMID: 27313224 [PubMed - as supplied by publisher] (Source: The Biochemical Journal)
Source: The Biochemical Journal - June 16, 2016 Category: Biochemistry Authors: Mahrhold S, Bergström T, Stern D, Dorner BG, Astot C, Rummel A Tags: Biochem J Source Type: research

Pleuroparenchymal fibroelastosis after allogenic hematopoietic stem cell transplantation: important histological component of late-onset noninfectious pulmonary complication accompanied with recurrent pneumothorax.
We report a case with pleuroparenchymal fibroelastosis (PPFE) occurred after allogenic bone marrow transplantation. The onset was infiltrative shadows in upper lobes, and the haziness spread gradually throughout the lungs with recurrent episodes of pneumothorax in both lungs. Progressive respiratory failure in course of adrenocortical steroid administration eventually caused death. Histological examination in general autopsy showed patchy subpleural fibrosis predominantly distributed in the upper lobes with substantial density rise of elastic fibers in the subpleural area, consistent with the diagnosis of PPFE. PPFE after ...
Source: International Journal of Hematology - June 16, 2016 Category: Hematology Authors: Matsui T, Maeda T, Kida T, Fujita J, Tsuji H, Morii E, Kanakura Y Tags: Int J Hematol Source Type: research

Antioxidant Vitamins and Trace Elements in Critical Illness.
Abstract This comprehensive narrative review summarizes relevant antioxidant mechanisms, the antioxidant status, and effects of supplementation in critically ill patients for the most studied antioxidant vitamins A, C, and E and the enzyme cofactor trace elements selenium and zinc. Over the past 15 years, oxidative stress-mediated cell damage has been recognized to be fundamental to the pathophysiology of various critical illnesses such as acute respiratory distress syndrome, ischemia-reperfusion injury, and multiorgan dysfunction in sepsis. Related to these conditions, low plasma levels of antioxidant enzymes, vit...
Source: Nutrition in Clinical Practice - June 16, 2016 Category: Nutrition Authors: Koekkoek WA, van Zanten AR Tags: Nutr Clin Pract Source Type: research

Injury and illness in aquatic sport: how high is the risk? A comparison of results from three FINA World Championships.
CONCLUSIONS: In aquatic sports, surveillance and health promotion should focus on prevention of out-of-competition overuse injuries and athlete education. PMID: 27313172 [PubMed - as supplied by publisher] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 16, 2016 Category: Sports Medicine Authors: Prien A, Mountjoy M, Miller J, Boyd K, van den Hoogenband C, Gerrard D, Cherif MY, Lu Y, Nanousis K, Ortiz Liscano EI, Shahpar FM, Junge A Tags: Br J Sports Med Source Type: research

Respiratory muscle impairment in dialysis patients: can minimal dose of exercise limit the damage? A Preliminary study in a sample of patients enrolled in the EXCITE trial.
CONCLUSION: In dialysis patients, a minimal dose of structured exercise improved physical capacity and maintained a stable respiratory muscle function, in contrast to the control group where it worsened. PMID: 27312989 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Source: Journal of Nephrology - June 16, 2016 Category: Urology & Nephrology Authors: Pomidori L, Lamberti N, Malagoni AM, Manfredini F, Pozzato E, Felisatti M, Catizone L, Barillà A, Zuccalà A, Tripepi G, Mallamaci F, Zoccali C, Cogo A Tags: J Nephrol Source Type: research

Standing on three legs: antiviral activities of RIG-I against influenza viruses.
Abstract Influenza A virus (FLUAV) is a severe pathogen of humans, able to unleash epidemics and pandemics of respiratory disease. For the host to survive virus infection, it is essential to rapidly recognize the pathogen and induce the synthesis of antiviral type I interferons (IFNs). The IFN system provides a broad spectrum of sensors that respond to conserved, virus-associated molecular patterns. For FLUAV, the RNA helicase RIG-I represents the major innate immune sensor, mainly binding and reacting to the 5' triphosphate dsRNA 'panhandle' that is formed by the conserved 5' and 3' end sequences of the viral ssRN...
Source: Current Opinion in Immunology - June 16, 2016 Category: Allergy & Immunology Authors: Weber-Gerlach M, Weber F Tags: Curr Opin Immunol Source Type: research

HMGB1 regulates IL-33 expression in acute respiratory distress syndrome.
Abstract The development and progression of acute respiratory distress syndrome (ARDS) has been shown to be regulated by cytokines. IL-33 and HMGB1 are conventionally considered as nuclear proteins and have a proinflammatory role. Studies have confirmed that HMGB1 has a significant role in ARDS, but few studies have provided direct evidence to confirm that IL33 is involved in ARDS. The purpose of our study was to determine whether IL-33 is elevated in ARDS and the relationship between IL-33 and HMGB1 in ARDS. We established a mouse model of LPS-induced lung inflammation/injury. Serum, bronchoalveolar lavage fluid (...
Source: International Immunopharmacology - June 16, 2016 Category: Allergy & Immunology Authors: Fu J, Lin SH, Wang CJ, Li SY, Feng XY, Liu Q, Xu F Tags: Int Immunopharmacol Source Type: research

Deciphering the interactions between the Bacillus cereus linear plasmid, pBClin15, and its host by high-throughput comparative proteomics.
Abstract The pathogen, Bacillus cereus, is able to adapt its metabolism to various environmental conditions. The reference strain, Benthesicymuscereus ATCC 14579, harbors a linear plasmid, pBClin15, which displays a cryptic prophage behavior. Here, we studied the impact of pBClin15 on the aerobic respiratory metabolism of B. cereus by curing its host strain. We compared, by means of a high-throughput shotgun proteomic approach, both the cellular proteome and the exoproteome of B. cereus ATCC 14579 in the presence and absence of pBClin15 at the early, late and stationary growth phases. The results were visualized th...
Source: Journal of Proteomics - June 16, 2016 Category: Biochemistry Authors: Madeira JP, Omer H, Alpha-Bazin B, Armengaud J, Duport C Tags: J Proteomics Source Type: research

The epidemiology and clinical features of Mycoplasma pneumoniae infection in neonates.
CONCLUSIONS: MP could be an important etiologic agent for respiratory tract infection in neonates. In neonates MP infection was usually associated with older age, presence of fever, and less tachypnea. MP infection in neonates tends to be a mild process. PMID: 27320858 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - June 16, 2016 Category: Infectious Diseases Authors: Huang F, Lu L, Jiang W, Yan Y, Ji W, Yang B, Yu S Tags: Braz J Infect Dis Source Type: research

[Community acquired acute respiratory infections caused by enterovirus D68 (EV-D68)].
PMID: 27321712 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - June 16, 2016 Category: Pediatrics Authors: Reina J, Cabrerizo M, Ferrés F Tags: An Pediatr (Barc) Source Type: research

Excessive variability in the performance and interpretation of the metacholine bronchial challenge test.
PMID: 27320405 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - June 16, 2016 Category: Respiratory Medicine Authors: Martínez Moragón E, Pérez de Llano L, Perpiñá M Tags: Arch Bronconeumol Source Type: research

Alpha-1 antitrypsin deficiency associated with the Mmalton variant. Description of a family.
PMID: 27320404 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - June 16, 2016 Category: Respiratory Medicine Authors: Figueira Gonçalves JM, Martínez Bugallo F, Díaz Pérez D, Martín Martínez MD, García-Talavera I Tags: Arch Bronconeumol Source Type: research

Comorbidities in chronic obstructive pulmonary diasease.
PMID: 27320403 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - June 16, 2016 Category: Respiratory Medicine Authors: Izquierdo Alonso JL Tags: Arch Bronconeumol Source Type: research

Differences in Health-related Quality of Life Between New Mexican Hispanic and Non-Hispanic White Smokers.
CONCLUSION: New Mexican Hispanic smokers have clinically relevant lower HRQL than their NHW counterparts. A perception of diminished physical functioning and impairment in daily-life activities contribute to the poorer HRQL among Hispanics. PMID: 27321735 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 16, 2016 Category: Respiratory Medicine Authors: Diaz AA, Petersen H, Meek P, Sood A, Celli B, Tesfaigzi Y Tags: Chest Source Type: research

Comorbidities and concurrent medications increasing the risk of adverse drug reactions: prevalence in French benzodiazepine users
Conclusions This study found that benzodiazepine use remained high in France, and that roughly half of the users presented with comorbidities and concurrent medications increasing the risk of ADRs. These findings are of concern, given that benzodiazepines are frequently used, and especially among the elderly. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - June 15, 2016 Category: Drugs & Pharmacology Source Type: research