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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Severe alpha-1 antitrypsin deficiency in composite heterozygotes inheriting a new splicing mutation QO Madrid
Conclusion: Finding pathogenic mutations in non-coding regions of the SERPINA1 highlight the importance that regulatory regions might have in the disease. Regulatory regions should be seriously considered in discordant cases with severe AAT deficiency where no coding mutations were found. (Source: Respiratory Research)
Source: Respiratory Research - October 7, 2014 Category: Respiratory Medicine Authors: Beatriz LaraMaria MartínezIgnacio BlancoCristina Hernández-MoroEladio VelascoIlaria FerrarottiFrancisco Rodriguez-FriasLaura PerezIrene VazquezJavier AlonsoManuel PosadaBeatriz Martínez-Delgado Source Type: research

Right Ventricular Global Longitudinal Strain Is an Independent Predictor of Right Ventricular Function: A Multimodality Study of Cardiac Magnetic Resonance Imaging, Real Time Three‐Dimensional Echocardiography and Speckle Tracking Echocardiography
ConclusionRVEF and volumes estimated on RT3DE were closely correlated with CMR measurements. When compared to more traditional markers of RV systolic function and RT3DE, RVGLS produced the highest correlation with CMR RVEF and was a good predictor of RV dysfunction. RV GLS should be considered a complementary modality to RT3DE and CMR in the assessment of RV systolic function. (Source: Echocardiography)
Source: Echocardiography - October 7, 2014 Category: Cardiology Authors: Ken J. Lu, Janet X. C. Chen, Konstantinos Profitis, Leighton G. Kearney, Dimuth DeSilva, Gerard Smith, Michelle Ord, Susan Harberts, Paul Calafiore, Elizabeth Jones, Piyush M. Srivastava Tags: Original Investigation Source Type: research

Hypothyroidism associated with acromegaly and insulin‐resistant diabetes mellitus in a Samoyed
ConclusionsTo the authors' knowledge, this is the first reported case that suggests that GH alterations may have clinical significance in naturally occurring hypothyroidism. Among other factors, hypothyroidism‐induced GH excess should be considered as a possible cause of IR in patients suffering from hypothyroidism and concurrent DM. In such cases, DM may reverse with treatment of hypothyroidism, as was documented in this case. (Source: Australian Veterinary Journal)
Source: Australian Veterinary Journal - October 7, 2014 Category: Veterinary Research Authors: T Johnstone, E Terzo, CT Mooney Tags: CASE REPORT AND CLINICAL REVIEW Source Type: research

What has research over the past two decades revealed about the adverse health effects of recreational cannabis use?
ConclusionsThe epidemiological literature in the past 20 years shows that cannabis use increases the risk of accidents and can produce dependence, and that there are consistent associations between regular cannabis use and poor psychosocial outcomes and mental health in adulthood. (Source: Addiction)
Source: Addiction - October 7, 2014 Category: Addiction Authors: Wayne Hall Tags: Monograph Source Type: research

Structural and functional analysis of the fibronectin binding protein FNE from Streptococcus equi subsp. equi
This article is protected by copyright. All rights reserved. Structured digital abstractGBD and FNE bind by isothermal titration calorimetry (View interaction)GBD 789FI and FNE bind by isothermal titration calorimetry (View interaction)FNE-CT and GBD 789FI bind by isothermal titration calorimetry (View interaction)GBD and FNE-CT bind by isothermal titration calorimetry (View interaction).FNE and GBD 789FI bind by molecular sieving (View interaction)FNE-CT binds to GBD 789FI by pull down (View interaction)FNE and GBD 789FI bind by x ray scattering (View interaction)GBD and FNE physically interact by fluorescence polarizatio...
Source: FEBS Journal - October 7, 2014 Category: Research Authors: Mounira Tiouajni, Dominique Durand, Karine Blondeau, Marc Graille, Agathe Urvoas, Marielle Valerio‐Lepiniec, Asma Guellouz, Magali Aumont‐Nicaise, Philippe Minard, Herman Tilbeurgh Tags: Original Article Source Type: research

Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials
This study examined the performance of the E-RS in each of 3 controlled trials with common and unique validation variables: one 6-month (N?=?235, US) and two 3-month (N?=?749; N?=?597; international). Subjects completed the E-RS as part of a daily eDiary. Tests of reliability, validity, and responsiveness were conducted in each dataset. Results: In each study, RS-Total score was internally consistent (Cronbach ?) (0.88, 0.92, 0.92) and reproducible (intra-class correlation) in stable patients (2?days apart: 0.91; 7?days apart: 0.71, 0.74). RS-Total scores correlated significantly with the following criterion variables (Spe...
Source: Respiratory Research - October 7, 2014 Category: Respiratory Medicine Authors: Nancy LeidyLindsey MurrayBrigitta MonzLinda NelsenMitchell GoldmanPaul JonesElizabeth DansieSanjay Sethi Source Type: research

Effects of Partial Inhibition of Respiratory Complex I on H2O 2 Production by Isolated Brain Mitochondria in Different Respiratory States.
Abstract The aim of this work was to characterize the effects of partial inhibition of respiratory complex I by rotenone on H2O2 production by isolated rat brain mitochondria in different respiratory states. Flow cytometric analysis of membrane potential in isolated mitochondria indicated that rotenone leads to uniform respiratory inhibition when added to a suspension of mitochondria. When mitochondria were incubated in the presence of a low concentration of rotenone (10 nm) and NADH-linked substrates, oxygen consumption was reduced from 45.9 ± 1.0 to 26.4 ± 2.6 nmol O2 mg(-1) min(-1) and from 7.8 ± 0....
Source: Neurochemical Research - October 7, 2014 Category: Neuroscience Authors: Michelini LG, Benevento CE, Rossato FA, Siqueira-Santos ES, Castilho RF Tags: Neurochem Res Source Type: research

Prick testing with chemicals in the diagnosis of occupational contact urticaria and respiratory diseases
ConclusionPrick tests can be safely used for diagnosing contact urticaria, asthma and rhinitis caused by isocyanates, chloramine‐T, persulfates, and chlorhexidine, but the results should be carefully interpreted and related to clinical symptoms and other diagnostic tests. (Source: Contact Dermatitis)
Source: Contact Dermatitis - October 7, 2014 Category: Dermatology Authors: Eva Helaskoski, Hille Suojalehto, Outi Kuuliala, Kristiina Aalto‐Korte Tags: Original Article Source Type: research

Interleukin-26 in Antibacterial Host Defense of Human Lungs: Effects on Neutrophil Mobilization.
Conclusion: This study implies that alveolar macrophages produce IL-26 that stimulates receptors on neutrophils and focuses their mobilization towards bacteria and accumulated immune cells in human lungs. PMID: 25291379 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 7, 2014 Category: Respiratory Medicine Authors: Che KF, Tengvall S, Levänen B, Silverpil E, Smith ME, Awad M, Vikström M, Palmberg L, Qvarfordt I, Sköld M, Lindén A Tags: Am J Respir Crit Care Med Source Type: research

Gastric Supply Manipulation to Modulate Ghrelin Production and Enhance Vascularization to the Cardia: Proof of the Concept in a Porcine Model.
Conclusions. Manipulation of the gastric flow targeting the gastroepiploic arcade induces ghrelin reduction. An endovascular approach is currently under evaluation. PMID: 25294792 [PubMed - as supplied by publisher] (Source: Surgical Innovation)
Source: Surgical Innovation - October 7, 2014 Category: Surgery Authors: Diana M, Halvax P, Pop R, Schlagowski I, Bour G, Liu YY, Legner A, Diemunsch P, Geny B, Dallemagne B, Beaujeux R, Demartines N, Marescaux J Tags: Surg Innov Source Type: research

Transumbilical Thoracoscopy Versus Conventional Thoracoscopy for Lung Wedge Resection: Safety and Efficacy in a Live Canine Model.
Conclusions. This study suggests that both approaches for performing lung wedge resection were comparable in efficacy and postoperative complications. PMID: 25294791 [PubMed - as supplied by publisher] (Source: Surgical Innovation)
Source: Surgical Innovation - October 7, 2014 Category: Surgery Authors: Chen TP, Yen-Chu, Wu YC, Yeh CJ, Liu CY, Hsieh MJ, Yuan HC, Ko PJ, Liu YH Tags: Surg Innov Source Type: research

Pulmonary arterial hypertension in congenital heart defects with left-to-right shunt.
PMID: 25304101 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 7, 2014 Category: Respiratory Medicine Authors: Martínez-Quintana E, Rodríguez-González F Tags: Arch Bronconeumol Source Type: research

Differences in clinical features of two immigrant populations with tuberculosis.
Abstract A study was performed to assess differences in the clinical presentation of tuberculosis between two groups of immigrants. Ninety-four patients seen in the emergency room for newly diagnosed tuberculosis between 2006 and 2012 were included. Forty-nine patients were from Asian countries and 45 from Latin America. Mean age [years (SD)] was 35.3 (13) in Asian patients and 33.9 (10) in Latin American patients. Asian subjects were predominantly male (40/49 vs 25/45; P=0.006). Patients from Latin American countries had a higher rate of pulmonary tuberculosis. A higher percentage of Asian patients lived in overcr...
Source: Archivos de Bronconeumologia - October 7, 2014 Category: Respiratory Medicine Authors: Supervía Caparrós A, Pallàs Villaronga O, Piccari L, Herrera Fernández S, Domínguez Álvarez M, Cirera Lorenzo I, Del Baño López F Tags: Arch Bronconeumol Source Type: research

Chronic thromboembolic pulmonary hypertension: Experience improves outcomes.
PMID: 25304099 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 7, 2014 Category: Respiratory Medicine Authors: Jiménez D, Zamorano JL Tags: Arch Bronconeumol Source Type: research

Serial Intervals of Respiratory Infectious Diseases: A Systematic Review and Analysis.
Abstract The serial interval of an infectious disease represents the duration between symptom onset of a primary case and symptom onset of its secondary cases. A good evidence base for such values is essential, because they allow investigators to identify epidemiologic links between cases and serve as an important parameter in epidemic transmission models used to design infection control strategies. We reviewed the literature for available data sets containing serial intervals and for reported values of serial intervals. We were able to collect data on outbreaks within households, which we reanalyzed to infer a mea...
Source: Am J Epidemiol - October 7, 2014 Category: Epidemiology Authors: Vink MA, Bootsma MC, Wallinga J Tags: Am J Epidemiol Source Type: research

Oral intake of Lactobacillus rhamnosus M21 enhances the survival rate of mice lethally infected with influenza virus.
CONCLUSION: These results demonstrate that orally administered L. rhamnosus M21 activates humoral as well as cellular immune responses, conferring increased resistance to the host against influenza virus infection. PMID: 25304268 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - October 7, 2014 Category: Microbiology Authors: Song JA, Kim HJ, Hong SK, Lee DH, Lee SW, Song CS, Kim KT, Choi IS, Lee JB, Park SY Tags: J Microbiol Immunol Infect Source Type: research

Btk-dependent epithelial cell rearrangements contribute to the invagination of nearby tubular structures in the posterior spiracles of Drosophila.
Abstract The Drosophila respiratory system consists of two connected organs, the tracheae and the spiracles. Together they ensure the efficient delivery of air-borne oxygen to all tissues. The posterior spiracles consist internally of the spiracular chamber, an invaginated tube with filtering properties that connects the main tracheal branch to the environment, and externally of the stigmatophore, an extensible epidermal structure that covers the spiracular chamber. The primordia of both components are first specified in the plane of the epidermis and subsequently the spiracular chamber is internalized through the ...
Source: Developmental Biology - October 7, 2014 Category: Biology Authors: Tsikala G, Karagogeos D, Strigini M Tags: Dev Biol Source Type: research

Role of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) signaling pathways in porcine reproductive and respiratory syndrome virus (PRRSV) replication.
Abstract Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is a positive sense, single-stranded RNA genome virus that has become a major infection in swine, exerting huge economic losses to the industry worldwide. Detailed knowledge concerning the molecular mechanisms by which the virus manipulates the host cell signal transduction machinery is not only critical to further our understanding of viral replication and pathogenesis, but also guides our efforts to design new and improved therapeutic strategies. The phosphatidylinositol-3-kinase (PI3K)-dependent Akt and the mammalian target of rapamycin (mTOR) ...
Source: Virus Research - October 7, 2014 Category: Virology Authors: Pujhari S, Kryworuchko M, Zakhartchouk AN Tags: Virus Res Source Type: research

Reprint of: Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis.
DISCUSSION: Early life exposure to allergens (house dust mite (HDM), furred pets, cockroach, rodent and mold), air pollution (nitrogen dioxide (NO2), ozone (O3), volatile organic compounds (VOCs), and particulate matter (PM)) and viral respiratory tract infections (Respiratory syncytial virus (RSV) and human rhinovirus (hRV)) has been implicated in the development of asthma in high risk children. Conversely, exposure to microbial diversity in the perinatal period may diminish the development of atopy and asthma symptoms. PMID: 25308874 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - October 7, 2014 Category: Allergy & Immunology Authors: Gaffin JM, Kanchongkittiphon W, Phipatanakul W Tags: Int Immunopharmacol Source Type: research

Soluble factors from colonic epithelial cells contribute to gut homeostasis by modulating macrophage phenotype.
In this study we examined the role of epithelial cells in inducing this intestinal macrophage phenotype. Using an in vitro system we showed that, in two-dimensional culture, epithelial cell-derived factors from a murine cell line, CMT-93, are sufficient to induce phenotypic changes in macrophages. Exposure of monocyte-derived macrophages, J774A.1, to soluble factors derived from epithelial cells, induced an altered phenotype similar to that of intestinal macrophages with decreased production of IL-12p40, IL-6 and IL-23 and expression of MHC ІІ and CD80 following TLR ligation. Furthermore, these conditioned macrophages s...
Source: Innate Immunity - October 7, 2014 Category: Allergy & Immunology Authors: Kristek M, Collins LE, DeCourcey J, McEvoy FA, Loscher CE Tags: Innate Immun Source Type: research

Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia
To report the experience with Middle East respiratory syndrome coronavirus (MERS-CoV) infection at a single center in Saudi Arabia. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - October 7, 2014 Category: Infectious Diseases Authors: Mustafa Saad, Ali S. Omrani, Kamran Baig, Abdelkarim Bahloul, Fatehi Elzein, Mohammad Abdul Matin, Mohei A.A. Selim, Mohammed Al Mutairi, Daifullah Al Nakhli, Amal Y. Al Aidaroos, Nisreen Al Sherbeeni, Hesham I. Al-Khashan, Ziad A. Memish, Ali M. Albarrak Source Type: research

[Some features of the nose in craniofacial malformations.]
Abstract In craniofacial malformations, the nose is variably affected: in its location, its shape or by lack of development. In this short chapter, some of the common problems encountered by the specialized teams are summarized. Craniofacial astronomies can modify the skeleton of the nose during growth, sometime at an early age. However, most rhinoplasties are performed at adulthood. The nasal pyramid may present deformations that produce functional and aesthetics impairment that should be treated when necessary. Respiratory problems should be recognized as early as possible and treated in priority. PMID: 25303...
Source: Annales de Chirurgie Plastique et Esthetique - October 7, 2014 Category: Cosmetic Surgery Authors: Arnaud E Tags: Ann Chir Plast Esthet Source Type: research

Pulmonary manifestations of inflammatory bowel disease.
Abstract Extraintestinal manifestations of inflammatory bowel disease (IBD) are a systemic illness that may affect up to half of all patients. Among the extraintestinal manifestations of IBD, those involving the lungs are relatively rare and often overlooked. However, there is a wide array of such manifestations, spanning from airway disease to lung parenchymal disease, thromboembolic disease, pleural disease, enteric-pulmonary fistulas, pulmonary function test abnormalities, and adverse drug reactions. The spectrum of IBD manifestations in the chest is broad, and the manifestations may mimic other diseases. Althou...
Source: World Journal of Gastroenterology : WJG - October 7, 2014 Category: Gastroenterology Authors: Ji XQ, Wang LX, Lu DG Tags: World J Gastroenterol Source Type: research

Effects of an additional pressure support level on exercise duration in patients on prolonged mechanical ventilation.
CONCLUSION: In patients undergoing PMV, an additional PS level of up to 4 cmH2O compared with the baseline setting may help to improve exercise tolerance by prolonging exercise duration. PMID: 25304086 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - October 7, 2014 Category: Journals (General) Authors: Chen YH, Lin HL, Hsiao HF, Huang CT, Kao KC, Li LF, Huang CC, Tsai YH Tags: J Formos Med Assoc Source Type: research

An unusual diagnosis of increasing respiratory failure after lung resection
(Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - October 6, 2014 Category: Emergency Medicine Source Type: research

Four-dimensional computed tomography based respiratory-gated radiotherapy with respiratory guidance system: analysis of respiratory signals and dosimetric comparison.
Conclusions. The reproducibility and regularity of respiratory amplitude and period were significantly improved with the complex system-guided breathing compared to the free or the audio-guided breathing. In addition, the treatment plan based on the 4D CT-based MIP images acquired with the complex system guided breathing showed better normal tissue sparing than that on the free breathing CT. PMID: 25276775 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - October 6, 2014 Category: Research Authors: Lee JA, Kim CY, Yang DS, Yoon WS, Park YJ, Lee S, Kim YB Tags: Biomed Res Int Source Type: research

Teva shedding 14 new drug candidates
Teva Pharmaceutical Industries Ltd. said Monday its discontinuing or divesting 14 new drug-development programs in non-core therapeutic areas. Going forward, Teva said its plans to focus its research and development efforts for branded products on two key areas: central nervous system disorders (including multiple sclerosis, neurodegenerative diseases and pain); and respiratory diseases (including asthma and chronic obstructive pulmonary disease.) “Our late-stage pipeline assets are expected… (Source: Health Care:Hospitals headlines)
Source: Health Care:Hospitals headlines - October 6, 2014 Category: Hospital Management Authors: John George Source Type: research

Optimization of acquisition parameters and accuracy of target motion trajectory for four-dimensional cone-beam computed tomography with a dynamic thorax phantom
Abstract Our purpose in this study was to evaluate the performance of four-dimensional computed tomography (4D-CBCT) and to optimize the acquisition parameters. We evaluated the relationship between the acquisition parameters of 4D-CBCT and the accuracy of the target motion trajectory using a dynamic thorax phantom. The target motion was created three dimensionally using target sizes of 2 and 3 cm, respiratory cycles of 4 and 8 s, and amplitudes of 1 and 2 cm. The 4D-CBCT data were acquired under two detector configurations: “small mode” and “medium mode”. The projection data acquired with scan times ra...
Source: Radiological Physics and Technology - October 6, 2014 Category: Physics Source Type: research

Zellweger syndrome and secondary mitochondrial myopathy
In conclusion, this is the first study of patients with a molecularly confirmed peroxisomal disorder with features of a concomitant mitochondrial myopathy and underscores the role of secondary mitochondrial dysfunction in Zellweger syndrome, potentially contributing to the clinical phenotype. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - October 6, 2014 Category: Pediatrics Source Type: research

Physical training for asthma.
CONCLUSIONS: This review demonstrated that physical training showed significant improvement in maximum oxygen uptake, though no effects were observed in other measures of pulmonary function. Physical training was well tolerated among people with asthma in the included studies and, as such, people with stable asthma should be encouraged to participate in regular exercise training, without fear of symptom exacerbation. More research is needed to understand the mechanisms by which physical activity impacts asthma management. PMID: 25272000 [PubMed - in process] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - October 6, 2014 Category: Journals (General) Authors: Carson KV, Chandratilleke MG, Picot J, Brinn MP, A AJ, Smith BJ Tags: Sao Paulo Med J Source Type: research

Self-reported exercise and longitudinal outcomes in cystic fibrosis: a retrospective cohort study
Conclusions: In our retrospective study, self-reported exercise was associated with improved longitudinal nutritional and pulmonary outcomes in cystic fibrosis for adults. Although prospective studies are needed to confirm these associations, programs to promote regular exercise among individuals with cystic fibrosis would be beneficial. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - October 6, 2014 Category: Respiratory Medicine Authors: Joseph CollacoScott BlackmanKaren RaraighChristopher MorrowGarry CuttingShruti Paranjape Source Type: research

In Vivo Interactions Between Cobalt or Ferric Compounds and the Pools of Sulphide in the Blood During and After H2S Poisoning
Hydrogen sulphide (H2S), a chemical hazard in oil and gas production, has recently become a dreadful method of suicide, posing specific risks and challenges for the first responders. Currently, there is no proven effective treatment against H2S poisoning and its severe neurological, respiratory or cardiac after-effects. We have recently described that H2S is present in various compartments, or pools, in the body during sulphide exposure, which have different levels of toxicity. The general goals of our study were to (1) determine the concentrations and kinetics of the various pools of hydrogen sulphide in the blood, i.e., ...
Source: Toxicological Sciences - October 6, 2014 Category: Toxicology Authors: Haouzi, P., Sonobe, T., Torsell-Tubbs, N., Prokopczyk, B., Chenuel, B., Klingerman, C. M. Tags: Clinical and Translational Toxicology Source Type: research

Isolation and characterization of a prokaryotic cell organelle from the anammox bacterium Kuenenia stuttgartiensis
Summary Anaerobic ammonium oxidizing (anammox) bacteria oxidize ammonium with nitrite to nitrogen gas in the absence of oxygen. These microorganisms form a significant sink for fixed nitrogen in the oceans and the anammox process is applied as a cost‐effective and environment‐friendly nitrogen removal system from wastewater. Anammox bacteria have a compartmentalized cell plan that consists of three separate compartments. Here we report the fractionation of the anammox bacterium Kuenenia stuttgartiensis in order to isolate and analyze the innermost cell compartment called the anammoxosome. The subcellular fractions were...
Source: Molecular Microbiology - October 6, 2014 Category: Microbiology Authors: Sarah Neumann, Hans J.C.T. Wessels, W. Irene C. Rijpstra, Jaap S. Sinninghe Damsté, Boran Kartal, Mike S.M. Jetten, Laura Niftrik Tags: Research Article Source Type: research

CD8(+)IL-17(+) T Cells Mediate Neutrophilic Airway Obliteration in T-bet Deficient Mouse Lung Allograft Recipients.
Abstract Acute cellular rejection is a known risk factor for the development of obliterative bronchiolitis which limits the long term survival of lung transplant recipients. However, the T cell effector mechanisms in both of these processes remain incompletely understood. Using the mouse orthotopic lung transplant model, we investigated whether C57BL/6 T-bet-/- recipients of MHC-mismatched BALB/c lung grafts develop rejection pathology and allospecific cytokine responses that differ from WT mice. T-bet-/- recipients demonstrated vigorous allograft rejection at 10 days, characterized by neutrophilic inflammation and...
Source: American Journal of Respiratory Cell and Molecular Biology - October 6, 2014 Category: Molecular Biology Authors: Lendermon EA, Dodd-O JM, Coon TA, Miller HL, Ganguly S, Popescu I, O'Donnell CP, Cardenes N, Levine M, Rojas M, Weathington NM, Zhao J, Zhao Y, McDyer JF Tags: Am J Respir Cell Mol Biol Source Type: research

Respiratory Syncytial Virus-Associated Hospitalizations in Pre-Mature Infants in Lima, Peru.
Abstract We conducted a prospective cohort study in four hospitals in Lima, Peru in infants with a birth weight ≤ 1,500 g followed from birth hospital discharge up to 1 year of age to determine the incidence of respiratory syncytial virus (RSV) hospitalizations. We enrolled 222 infants from March of 2009 to March of 2010 infants: 48 infants with a birth weight < 1,000 g and 174 infants with a birth weight of 1,000-1,500 g (birth weight = 1,197 ± 224 g; gestational age = 30.1 ± 2.6 weeks). There were 936 episodes of respiratory infections; the incidence of respiratory infections during the first 1 year of lif...
Source: The American Journal of Tropical Medicine and Hygiene - October 6, 2014 Category: Tropical Medicine Authors: Ochoa TJ, Bautista R, Dávila C, Salazar JA, Bazán C, Guerra O, Llanos JP, López L, Zea-Vera A, Ecker L Tags: Am J Trop Med Hyg Source Type: research

Pulmonary rehabilitation for interstitial lung disease.
CONCLUSIONS: Pulmonary rehabilitation seems to be safe for people with ILD. Improvements in functional exercise capacity, dyspnoea and quality of life are seen immediately following pulmonary rehabilitation, with benefits also evident in IPF. Because of inadequate reporting of methods and small numbers of included participants, the quality of evidence was low to moderate. Little evidence was available regarding longer-term effects of pulmonary rehabilitation. PMID: 25284270 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 6, 2014 Category: Journals (General) Authors: Dowman L, Hill CJ, Holland AE Tags: Cochrane Database Syst Rev Source Type: research

[ARAPOC Study: Prevalence of respiratory symptoms and chronic obstructive pulmonary disease in the general population.]
CONCLUSIONS: The high prevalence of COPD and the significant level of underdiagnoses lead to believe that early diagnosis of this disease is still a pending issue. New strategies need to be developed to resolve this problem. PMID: 25300462 [PubMed - as supplied by publisher] (Source: Atencion Primaria)
Source: Atencion Primaria - October 6, 2014 Category: Primary Care Authors: Bruscas Alijarde MJ, Naberan Toña K, Lambán Sánchez MT, Bello Dronda S Tags: Aten Primaria Source Type: research

Sternal tuberculosis: The role of imaging.
PMID: 25301413 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 6, 2014 Category: Respiratory Medicine Authors: Canella C, Zanetti G, Marchiori E Tags: Arch Bronconeumol Source Type: research

Combination of tracheal bronchus and partial anomalous pulmonary venous return in a patient with type 1 neurofibromatosis and ipsilateral vagal nerve neurofibroma.
PMID: 25301412 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 6, 2014 Category: Respiratory Medicine Authors: Gorospe Sarasúa L, Saldaña Garrido D, Ayala Carbonero AM Tags: Arch Bronconeumol Source Type: research

Procollagen Type I and III Aminoterminal Propeptide Levels and Severity of Interstitial Lung Disease in Mexican Women With Progressive Systemic Sclerosis.
CONCLUSIONS: PINP and PIIINP are useful markers for severe ILD+SSc, suggesting they could play a role in the follow-up of this complication in SSc. PMID: 25301411 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 6, 2014 Category: Respiratory Medicine Authors: Gonzalez-Lopez L, Rocha-Muñoz AD, Olivas-Flores EM, Garcia-Gonzalez A, Peguero-Gómez AR, Flores-Navarro J, Villa-Manzano AI, Zavaleta-Muñiz SA, Salazar-Paramo M, Mejía M, Juárez-Contreras P, Vazquez-Del Mercado M, Cardona-Muñoz EG, Trujillo-Hernánd Tags: Arch Bronconeumol Source Type: research

Characteristics of candidates for lung transplantation due to chronic obstructive pulmonary disease and alpha-1 antitrypsin deficiency emphysema.
CONCLUSIONS: The number of patients receiving a lung transplant for COPD has progressively increased and the tendency is to perform the evaluation in earlier stages of the disease. Patients receiving transplants for COPD and AATD had similar characteristics at the time of the evaluation, although AATD patients were younger and had less exposure to tobacco and lower PCO2. PMID: 25301410 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 6, 2014 Category: Respiratory Medicine Authors: Giacoboni D, Barrecheguren M, Esquinas C, Rodríguez E, Berastegui C, López-Meseguer M, Monforte V, Bravo C, Pirina P, Miravitlles M, Román A Tags: Arch Bronconeumol Source Type: research

Generation of porcine reproductive and respiratory syndrome virus by in vitro assembly of viral genomic cDNA fragments.
In conclusion, this study describes for the first time the use of GA as a simple, yet powerful tool for generating infectious PRRSV needed for studying PRRSV biology and developing novel vaccines. PMID: 25300804 [PubMed - as supplied by publisher] (Source: Virus Research)
Source: Virus Research - October 6, 2014 Category: Virology Authors: Suhardiman M, Kramyu J, Narkpuk J, Jongkaewwattana A, Wanasen N Tags: Virus Res Source Type: research

Adult-Onset Recurrent Respiratory Papillomatosis May Be Associated with Number of Sexual Partners
What risk factors, if any, are strongly associated with adult-onset recurrent respiratory papillomatosis (AO-RRP)? (Source: ENT Today)
Source: ENT Today - October 5, 2014 Category: ENT & OMF Authors: Amy Eckner Tags: Laryngology Literature Reviews Practice Focus HPV Source Type: research

Protein and microRNA biomarkers from lavage, urine, and serum in military personnel evaluated for dyspnea
Conclusions: Candidate proteins and miRNAs associated with the general diagnosis of dyspnea have been identified in subjects with differing medical diagnoses. Since these markers can be measured in readily obtained clinical samples, further studies are possible that test the value of these findings in more formal classification or case-control studies in much larger cohorts of subjects with specific lung diseases such as asthma, emphysema, or some other well-defined lung disease. (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - October 5, 2014 Category: Genetics & Stem Cells Authors: Joseph BrownHeather BrewerCarrie NicoraKarl WeitzMichael MorrisAndrew SkabelundJoshua AdkinsRichard SmithJi-Hoon ChoRichard Gelinas Source Type: research

Anticholinergics/Antimuscarinic Drugs in Asthma
Abstract Anticholinergic alkaloids have been used for thousands of years for the relief of bronchoconstriction and other respiratory symptoms, and their use in the treatment of chronic obstructive pulmonary disease is well established. Acetylcholine, acting through muscarinic receptor (M) receptor, modulates multiple physiologic functions pertinent to asthma including airway muscle tone, mucus gland secretion, and various parameters of inflammation and remodeling. In addition, activation of M receptors may inhibit beta2 adrenoreceptor. These observations offer the rationale for the use of M receptors antagonists ...
Source: Current Allergy and Asthma Reports - October 5, 2014 Category: Allergy & Immunology Source Type: research

Validation method to determine metals in atmospheric particulate matter by inductively coupled plasma optical emission spectrometry
Atmospheric particulate matter (PM) is a pollutant composed by various metals, that when accumulated in the respiratory system may cause serious health problems. Methods IO-3.1 (metal extraction in PM) and IO-3.4 [metal determination by inductively coupled plasma optical emission spectrometry (ICP-OES)] are the recommended by the United State Environmental Protection Agency. With the intent to evaluate the performance of the method developed in our laboratory for the extraction of metal in PM with HNO3 p.a. bidistilled and determination by ICP-OES of Al, Ca, Cd, Cu, Cr, Fe, K, Mg, Mn, Na, Ni, Pb, Ti, V and Zn, validation w...
Source: Journal of the Brazilian Chemical Society - October 4, 2014 Category: Chemistry Source Type: research