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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Immune Response and Mortality Risk Relate to Distinct Lung Microbiomes in HIV-Pneumonia Patients.
CONCLUSIONS: These data provide evidence that compositionally and structurally distinct lower airway microbiomes are associated with discrete local host immune responses, peripheral metabolic reprogramming, and different rates of mortality. PMID: 27447987 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 22, 2016 Category: Respiratory Medicine Authors: Shenoy MK, Iwai S, Lin DL, Worodria W, Ayakaka I, Byanyima P, Kaswabuli S, Fong S, Stone S, Chang E, Davis JL, Faruqi AA, Segal MR, Huang L, Lynch SV Tags: Am J Respir Crit Care Med Source Type: research

Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis.
CONCLUSIONS: Abnormal glucose tolerance is notably prevalent among young children with cystic fibrosis. Children with cystic fibrosis lack the normal increase in insulin secretion that occurs in early childhood despite increased glucose. These findings demonstrate glycemic abnormalities begin very early in cystic fibrosis, possibly due to insufficient insulin secretion. PMID: 27447840 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 22, 2016 Category: Respiratory Medicine Authors: Yi Y, Norris AW, Wang K, Sun X, Uc A, Moran A, Engelhardt JF, Larson Ode K Tags: Am J Respir Crit Care Med Source Type: research

Identification of Epithelial Phospholipase A2 Receptor 1 (PLA2R1) as a Potential Target in Asthma.
CONCLUSIONS: PLA2R1 is increased in the airway epithelium in asthma, and serves as a regulator of AHR, airway permeability, antigen sensitization, and airway inflammation. PMID: 27448109 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - July 22, 2016 Category: Respiratory Medicine Authors: Nolin JD, Ogden HL, Lai Y, Altemeier WA, Frevert CW, Bollinger JG, Naika GS, Kicic A, Stick SM, Lambeau G, Henderson WR, Gelb MH, Hallstrand TS Tags: Am J Respir Cell Mol Biol Source Type: research

The NLRP3 Inflammasome Regulates Bronchial Epithelial Cell Injury and Pro-apoptosis After Exposure to Biomass Fuel Smoke.
In this study, we investigated the expression of pyrin domain containing protein 3 (NLRP3) and caspase-1 in the bronchial epithelium from COPD patients, and further determined the specific role of the NLRP3 inflammasome in bronchial epithelium injury using two in vitro models (BS and cigarette smoke (CS)) in the human bronchial epithelial cell line (16HBE). After exposure to BS and CS, the release of damage-associated molecular patterns (DAMPs), the transcriptional and translational upregulation of NLRP3, and the activation of caspase-1 were observed in cells at different time points. Since IL-1β secretion was dependent o...
Source: Am J Respir Cell Mol... - July 22, 2016 Category: Respiratory Medicine Authors: Li C, Zhihong H, Wenlong L, Xiaoyan L, Qing C, Wenzhi L, Siming X, Shengming L Tags: Am J Respir Cell Mol Biol Source Type: research

GLP1-R: a Novel Pharmacological Target for Treating Human Bronchial Hyperresponsiveness.
In conclusion, GLP1-R may represent a novel target for treating BHR by activating the cAMP-dependent PKA pathway in human airways, and GLP1-R agonists could be used as a 'new' class to treat asthmatic patients and T2DM patients with BHR. PMID: 27447052 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - July 22, 2016 Category: Respiratory Medicine Authors: Rogliani P, Calzetta L, Capuani B, Facciolo F, Cazzola M, Lauro D, Matera MG Tags: Am J Respir Cell Mol Biol Source Type: research

Environmentally-induced return to juvenile-like chemosensitivity in the respiratory control system of adult bullfrogs, Lithobates catesbeianus.
This article is protected by copyright. All rights reserved. PMID: 27444338 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - July 22, 2016 Category: Physiology Authors: Santin JM, Hartzler LK Tags: J Physiol Source Type: research

Prevalence of Respiratory Protective Devices in U.S. Health Care Facilities: Implications for Emergency Preparedness
An online questionnaire was developed to explore respiratory protective device (RPD) prevalence in U.S. health care facilities. The survey was distributed to professional nursing society members in 2014 and again in 2015 receiving 322 and 232 participant responses, respectively. The purpose of this study was to explore if the emergency preparedness climate associated with Ebola virus disease changed the landscape of RPD use and awareness. Comparing response percentages from the two sampling time frames using bivariate analysis, no significant changes were found in types of RPDs used in health care settings. N95 filtering f...
Source: Workplace Health and Safety - July 22, 2016 Category: Occupational Health Authors: Wizner, K., Stradtman, L., Novak, D., Shaffer, R. Tags: Articles Source Type: research

Care Setting Intensity and Outcomes After Emergency Department Presentation Among Patients With Acute Heart Failure [Health Services and Outcomes Research]
Conclusions Respiratory factors were associated with admission to higher-intensity settings. There was no difference in early survival between some lower-risk patients admitted to higher-intensity units compared to those treated in lower-intensity settings. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - July 22, 2016 Category: Cardiology Authors: Goldraich, L., Austin, P. C., Zhou, L., Tu, J. V., Schull, M. J., Mak, S., Ross, H. J., Morrow, D. A., Lee, D. S. Tags: Heart Failure, Health Services, Quality and Outcomes Health Services and Outcomes Research Source Type: research

Ode to the exocrine pancreas
Prevention and treatment of malnutrition are the major focus of care in patients with cystic fibrosis (CF) due to the close relationship between nutritional status, pulmonary function and survival. Exocrine pancreatic insufficiency (PI) occurs in approximately 85% of patients with CF [1], therefore the assessment of exocrine pancreatic function and optimal delivery of pancreatic enzyme replacement therapy (PERT) are important facets of management. Three original articles relating to these aspects are published in this issue of the Journal of Cystic Fibrosis [2 –4]. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 22, 2016 Category: Respiratory Medicine Authors: Michael J. Coffey, Chee Y. Ooi Tags: Editorial Source Type: research

A product of immunoreactive trypsinogen and pancreatitis-associated protein as second-tier strategy in cystic fibrosis newborn screening
In cystic fibrosis newborn screening (CFNBS), immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP) can be used as screening parameters. We evaluated the IRT ×PAP product as second-tier parameter in CFNBS in newborns with elevated IRT. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 22, 2016 Category: Respiratory Medicine Authors: Sophia Weidler, Konrad H. Stopsack, Jutta Hammermann, Olaf Sommerburg, Marcus A. Mall, Georg F. Hoffmann, Dirk Kohlm üller, Jürgen G. Okun, Milan Macek, Felix Votava, Veronika Krulišová, Miroslava Balaščaková, Veronika Skalická, Min Ae Lee-Kirsch, Tags: Original Article Source Type: research

The potential role of training sessions on the temporal and spatial physiological patterns in young Friesian horses
This study compares the circulating ACTH, cortisol, lactate, glucose, heart rate, respiratory rate, rectal temperature and blood count values in initially 2-years old horses subjected to dressage training schedule during three consecutive days per two weeks. Sixteen healthy Friesian horses were used and were considered dressage group. Six healthy young horses not involved in training programmes were used as control group. Blood sampling were collected from the jugular vein in baseline condition (dressage group and control group) and after exercise, within five minutes of the end of the training session (dressage group). (S...
Source: Journal of Equine Veterinary Science - July 22, 2016 Category: Veterinary Research Authors: E. Fazio, P. Medica, F. Aveni, A. Ferlazzo Tags: Original Research Source Type: research

Intravenous magnesium sulfate for treating children with acute asthma in the emergency department
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - July 22, 2016 Category: Respiratory Medicine Authors: Benedict Griffiths, Kayleigh M Kew, Rebecca Normansell Tags: Cochrane Corner for Paediatric Respiratory Reviews Source Type: research

NF- κB1 Haploinsufficiency Causing Immunodeficiency and EBV-Driven Lymphoproliferation
Conclusions < /h3 > < p class= " a-plus-plus " > Deficiency of NF- κB1 leads to immunodeficiency with a wider phenotypic spectrum of disease manifestation than previously appreciated, including EBV lymphoproliferative diseases as a hitherto unrecognized feature of the disease. < /p > < /span > (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - July 21, 2016 Category: Allergy & Immunology Source Type: research

Efficacy, Safety, and Pharmacokinetics of a New 10  % Liquid Intravenous Immunoglobulin Containing High Titer Neutralizing Antibody to RSV and Other Respiratory Viruses in Subjects with Primary Immunodeficiency Disease
Conclusions < /h3 > < p class= " a-plus-plus " > There were zero serious bacterial infections, thus meeting the primary endpoint for this trial. The secondary endpoints including days missed from work due to infection, unscheduled visits to the physician, and days of hospitalization due to infection compared favorably to published reports of other IVIG products. < /p > < /span > (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - July 21, 2016 Category: Allergy & Immunology Source Type: research

Asthma –Chronic Obstructive Pulmonary Disease Overlap Syndrome
We describe the clinical characteristics of this subtype of disease and suggest 4 working definitions of individuals who would fall into the asthma –COPD overlap category. Understanding the mechanisms underlying these subtypes will hopefully lead into a better understanding of therapeutic strategies that can target specific pathobiologic pathways. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - July 21, 2016 Category: Allergy & Immunology Authors: Nirupama Putcha, Robert A. Wise Source Type: research

Enhanced expression levels of aquaporin-1 and aquaporin-4 in A549 cells exposed to silicon dioxide.
Authors: Hao X, Wang H, Liu W, Liu S, Peng Z, Sun Y, Zhao J, Jiang Q, Liu H Abstract Aquaporins (AQPs), water channel proteins in the cell membranes of mammals, have been reported to be important in maintaining the water balance of the respiratory system. However, little is known regarding the role of AQP in occupational pulmonary diseases such as silicosis. The present study investigated the expression of AQP1 and AQP4 in the human A549 alveolar epithelial cell line stimulated by silica (SiO2). A549 cells were cultured and divided into four groups: Control, SiO2‑stimulated, AQP1 inhibitor and AQP4 inhibitor. The...
Source: Molecular Medicine Reports - July 21, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

TLR4 Overexpression Inhibits Endothelial PAS Domain-Containing Protein 1 Expression in the Lower Respiratory Tract of Patients with Chronic COPD
Conclusion: < /i > < /b > These findings suggest that TLR4 over-expression decreased EPAS1expression which contributes to the progress of COPD. < br / > Cell Physiol Biochem 2016;39:685-692 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 21, 2016 Category: Cytology Source Type: research

Influenza ‐like illness‐related emergency department visits: Christmas and New Year holiday peaks and relationships with laboratory‐confirmed respiratory virus detections, Edmonton, Alberta, 2004‐2014
ConclusionsDuring non‐pandemic years, ILI‐related ED visit volumes were associated with variations in detections for influenza A and RSV and always peaked during the Christmas‐New Year holidays. This predictability should be used to prepare for, and possibly prevent, this increase in healthcare use; however, interventions beyond disease prevention strategies are likely needed.This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - July 21, 2016 Category: Virology Authors: Leah J Martin, Cindy Im, Huiru Dong, Bonita E Lee, James Talbot, David P Meurer, Shamir N Mukhi, Steven J Drews, Yutaka Yasui Tags: Original Article Source Type: research

Inhalation Exposure to Dioxins and dl-PCBs Depending on the Season in Upper Silesia, Poland: A Pilot Study.
CONCLUSIONS: Air pollution can be a significant source of dioxin and dl-PCB for people during the winter season, as a result of co-burning coal and waste containing plastics. The dose of dioxins inhaled through the respiratory pathway in winter can be associated with the higher cancer risk in the population of Upper Silesia. PMID: 27434241 [PubMed - in process] (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - July 21, 2016 Category: Global & Universal Tags: Cent Eur J Public Health Source Type: research

Clinically remitted childhood asthma is associated with airflow obstruction in middle‐aged adults
ConclusionClinically remitted childhood asthma is associated with airflow obstruction in middle‐aged adults. Smoking and remitted childhood asthma may be additive factors for the development of airflow obstruction. (Source: Respirology)
Source: Respirology - July 21, 2016 Category: Respiratory Medicine Authors: Keitaro Omori, Hiroshi Iwamoto, Takashi Yamane, Taku Nakashima, Yoshinori Haruta, Noboru Hattori, Akihito Yokoyama, Nobuoki Kohno Tags: Original Article Source Type: research

Estimating Respiratory Syncytial Virus-associated Hospitalization in the First Year of Life Among Infants Born at 32–35 Weeks of Gestation
Background: Prophylaxis against respiratory syncytial virus-associated hospitalization (RSV-H) with anti-RSV monoclonal antibody is not considered cost-effective for routine use in most jurisdictions. The aim of this study was to develop a scoring tool to estimate local risk of RSV-H in the first year of life among moderately premature infants to assist in prophylaxis decision making. Methods: A retrospective cohort was constructed from population-based databases in Nova Scotia, Canada, to follow 32- to 35-week gestation infants from the prenatal period to (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 21, 2016 Category: Infectious Diseases Tags: Original Studies Source Type: research

Survival of an Enveloped Virus on Toys
Children’s toys may carry respiratory viruses. Inactivation of a lipid-enveloped bacteriophage, Φ6, was measured on a nonporous toy at indoor temperature and relative humidity (RH). Inactivation was approximately 2log10 after 24 hours at 60% RH and 6.8log10 at 10 hours at 40% RH. Enveloped viruses can potentially survive on toys long enough to result in exposures. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 21, 2016 Category: Infectious Diseases Tags: Brief Reports Source Type: research

Diagnosis of Pediatric Acute Adenovirus Infections: Is a Positive PCR Sufficient?
Conclusions: Species identification and viral burden may assist in interpretation of a positive HAdV result. Low viral burden with HAdV-C may be consistent with incidental detection. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 21, 2016 Category: Infectious Diseases Tags: Original Studies Source Type: research

Association between levels of fractional exhaled nitric oxide and asthma exacerbations in Thai children
ConclusionThe optimal cut‐off point of FeNO level for the prediction of AE is 31 ppb. AE within the next 12 months was significantly more common in patients with higher FeNO levels and in patients with a higher rate of previous 12‐month exacerbations. (Source: Respirology)
Source: Respirology - July 21, 2016 Category: Respiratory Medicine Authors: Nualanong Visitsunthorn, Nawinda Mahawichit, Kittipong Maneechotesuwan Tags: Original Article Source Type: research

2′,5′-Oligoadenylate synthetase 1(OAS1) inhibits PRRSV replication in Marc-145 cells
Publication date: August 2016 Source:Antiviral Research, Volume 132 Author(s): Jinhua Zhao, Na Feng, Zhenhong Li, Peng Wang, Ziyu Qi, Wan Liang, Xiang Zhou, Xuewen Xu, Bang Liu Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically destructive disease for global pig industry. Although its invasion mechanism is clear, the knowledge of pathogen and host interaction is less known. Here, we found that PPRSV infection led to induction of 2′, 5′-oligoadenylate synthetase gene 1(OAS1), an important interferon-stimulated gene. More importantly, ectopic overexpression of OAS1 significantly res...
Source: Antiviral Therapy - July 21, 2016 Category: Virology Source Type: research

Optimizing diagnostic tests for persulphate-induced respiratory diseases
Conclusions The proposed method for performing SIC showed a high specificity for detecting persulphate-induced asthma and rhinitis. The rapid SIC was able to produce positive nasal and bronchial responses in symptomatic hairdressers without any severe reactions occurring. SPTs and HRTs cannot predict asthma or rhinitis caused by persulphates. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 21, 2016 Category: Allergy & Immunology Source Type: research

Validation of the Italian version of the SBMA Functional Rating Scale as outcome measure
In conclusion, we performed an Italian validation of the only existing disease-specific Functional Rating Scale for SBMA patients. This scale will be a useful tool not only in the clinical practice but also as an outcome measure in upcoming clinical trials. (Source: Neurological Sciences)
Source: Neurological Sciences - July 21, 2016 Category: Neurology Source Type: research

Evaluation of malnutrition as a predictor of adverse outcomes in febrile neutropenia associated with paediatric haematological malignancies
ConclusionMalnutrition may be a potential predictor of mortality in febrile neutropenia. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - July 21, 2016 Category: Pediatrics Authors: Jasodhara Chaudhuri, Tamoghna Biswas, Jyotishka Datta, Tapas Kumar Sabui, Sukanta Chatterjee, Somosri Ray, Dibyendu Raychaudhuri, Kalyanbrata Mandal, Kaushani Chatterjee, Swapna Chakraborty Tags: Original Article Source Type: research

Neonatal outcomes after prelabour rupture of membranes before 24 weeks' gestation
ConclusionsAlmost one‐third of pregnancies complicated by PROM before 24 weeks resulted in pre‐viable preterm delivery. In pregnancies continuing to a viable gestation, there remained a significant risk of neonatal mortality and morbidity, primarily due to respiratory disease. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - July 21, 2016 Category: Pediatrics Authors: Linda M McLaughlin, Glenn J Gardener Tags: Original Article Source Type: research

A mitochondria ‐targeted antioxidant can inhibit peroxidase activity of cytochrome c by detachment of the protein from liposomes
This article is protected by copyright. All rights reserved. (Source: FEBS Letters)
Source: FEBS Letters - July 21, 2016 Category: Biochemistry Authors: Alexander M. Firsov, Elena A. Kotova, Viktor N. Orlov, Yuri N. Antonenko, Vladimir P. Skulachev Tags: Research Letter Source Type: research

The multitude of iron –sulfur clusters in respiratory complex I
This article is part of a Special Issue entitled ‘EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2–6, 2016’, edited by Prof. Paolo Bernardi. (Source: Biochimica et Biophysica Acta (BBA) Bioenergetics)
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - July 21, 2016 Category: Biochemistry Source Type: research

Mitochondrial disease-related mutations at the cytochrome b-iron –sulfur protein (ISP) interface: Molecular effects on the large-scale motion of ISP and superoxide generation studied in Rhodobacter capsulatus cytochrome bc1
This article is part of a Special Issue entitled ‘EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2–6, 2016’, edited by Prof. Paolo Bernardi. (Source: Biochimica et Biophysica Acta (BBA) Bioenergetics)
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - July 21, 2016 Category: Biochemistry Source Type: research

Do respiratory limitations affect metabolism of insect larvae before moulting: an empirical test at the individual level [RESEARCH ARTICLE]
Sami M. Kivelä, Philipp Lehmann, and Karl GotthardRecent data suggest that oxygen limitation may induce moulting in larval insects. This oxygen dependent induction of moulting (ODIM) hypothesis stems from the fact that the tracheal respiratory system of insects grows primarily at moults, whereas tissue mass increases massively between moults. This may result in a mismatch between oxygen supply and demand at the end of each larval instar because oxygen demand of growing tissues exceeds the relatively fixed supply capacity of the respiratory system. The ODIM hypothesis predicts that, within larval instars, respiratio...
Source: Journal of Experimental Biology - July 21, 2016 Category: Biology Authors: Kivelä, S. M., Lehmann, P., Gotthard, K. Tags: RESEARCH ARTICLE Source Type: research

Effects of thermal stress on the immune and oxidative stress responses of juvenile sea cucumber Holothuria scabra
< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > < em class= " a-plus-plus " > Holothuria scabra < /em > is the most valued and cultured tropical sea cucumber, given the great demand of this species for human consumption. However, despite its ecological and economic relevance, little is known regarding its immune responses under thermal stress. Here, the main goal was to study the response of sea cucumbers to temperature stress, assessing sub-organismal alterations and acclimation capacities of juveniles to temperature changes. After changing temperature (1  °C/day) for 6 days, organisms were ...
Source: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology - July 21, 2016 Category: Physiology Source Type: research

Engineered cationic antimicrobial peptide (eCAP) prevents Pseudomonas aeruginosa biofilm growth on airway epithelial cells
Conclusions While other studies have demonstrated the ability of natural and synthetic antimicrobial peptides to prevent abiotic bacterial biofilm formation, the current studies for the first time demonstrate the effective peptide treatment of a biotic bacterial biofilm in a setting similar to the CF airway, and without negative effects on human airway epithelial cells, thus highlighting the unique potential of this engineered cationic antimicrobial peptide for treatment of human respiratory infections. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - July 21, 2016 Category: Microbiology Authors: Lashua, L. P., Melvin, J. A., Deslouches, B., Pilewski, J. M., Montelaro, R. C., Bomberger, J. M. Tags: Original research Source Type: research

Chapter 6 Low-Density TaqMan ® Array Cards for the Detection of Pathogens
Publication date: 2015 Source:Methods in Microbiology, Volume 42 Author(s): Jude Heaney, Kathryn Rolfe, Nicholas S. Gleadall, Jane S. Greatorex, Martin D. Curran Real-time PCR assays have revolutionised diagnostic microbiology over the past 15 years or more. Adaptations and improvements over that time frame have led to the development of multiplex assays. However, limitations in terms of available fluorophores has meant the number of assays which can be combined has remained in single figures. This latter limitation has led to the focus tending to be on individual pathogens and their detection. This chapter describe...
Source: Methods in Microbiology - July 21, 2016 Category: Microbiology Source Type: research

Oseltamivir resistance in an influenza A (H3N2) virus isolated from an immunocompromised patient during the 2014 ‐2015 influenza season in Alberta, Canada
This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - July 21, 2016 Category: Virology Authors: Ahsan Chaudhry, Nathalie Bastien, Yan Li, Allison Scott, Kanti Pabbaraju, Douglas Stewart, Sallene Wong, Steven J. Drews Tags: Short Article Source Type: research

Hospital Surveillance of Influenza Strains: A Concordant Image of Viruses Identified by the Swiss Sentinel System?
ConclusionsAlthough an influenza surveillance system based on the community can predict the type of influenza strains that will be associated with hospitalizations, it fails to estimate the potential virulence of circulating strains. Further, the population characteristics in the community differ from those in hospitalized patients. This suggests that any national influenza surveillance system should include both community and hospital‐based surveys.This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - July 21, 2016 Category: Virology Authors: Ana Rita Gon çalves, Anne Iten, Patricia Suter‐Boquete, Manuel Schibler, Laurent Kaiser, Samuel Cordey Tags: Original Article Source Type: research

Epidemiology and Clinical Characteristics of Respiratory Syncytial Virus Infections among Children and Adults in Mexico
ConclusionsThis study confirms that RSV is an important respiratory pathogen in children in Mexico. In addition, a substantial number of cases in adults were also detected highlighting the relevance of this virus in all ages. It is important to identify subjects at high risk of complications who may benefit from current or future preventive interventions.This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - July 21, 2016 Category: Virology Authors: Ana E. Gami ño‐Arroyo, Sarbelio Moreno‐Espinosa, Beatriz Llamosas‐Gallardo, Ana A. Ortiz‐Hernández, M. Lourdes Guerrero, Arturo Galindo‐Fraga, Juan F. Galán‐Herrera, Francisco J. Prado‐Galbarro, John H. Beigel, Guillermo M. Ruiz‐Palacio Tags: Original Article Source Type: research

2 ′,5′-Oligoadenylate synthetase 1(OAS1) inhibits PRRSV replication in Marc-145 cells
Publication date: August 2016 Source:Antiviral Research, Volume 132 Author(s): Jinhua Zhao, Na Feng, Zhenhong Li, Peng Wang, Ziyu Qi, Wan Liang, Xiang Zhou, Xuewen Xu, Bang Liu Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically destructive disease for global pig industry. Although its invasion mechanism is clear, the knowledge of pathogen and host interaction is less known. Here, we found that PPRSV infection led to induction of 2′, 5′-oligoadenylate synthetase gene 1(OAS1), an important interferon-stimulated gene. More importantly, ectopic overexpression of OAS1 significantly res...
Source: Antiviral Therapy - July 21, 2016 Category: Virology Source Type: research

Goals of care discussions among hospitalized long ‐term care residents: Predictors and associated outcomes of care
CONCLUSIONIn hospitalized LTC patients, GOC discussions occurred infrequently and appeared to be triggered by illness severity. Orders for advance directives, in‐hospital death, and 1‐year mortality were associated with discussions. Rates of GOC documentation in the discharge summary were poor. This study provides direction for developing education and practice standards to improve GOC discussion rates and their communication back to LTC. Journal of Hospital Medicine 2016. © 2016 Society of Hospital Medicine (Source: Journal of Hospital Medicine)
Source: Journal of Hospital Medicine - July 21, 2016 Category: Hospital Management Authors: Hannah J. Wong, Jamie Wang, Michelle Grinman, Robert C. Wu Tags: Original Research Source Type: research

The outcomes of early aneurysm repair in World Federation of Neurosurgical Societies grade V subarachnoid haemorrhage patients with emphasis on those presenting with a Glasgow Coma Scale score of 3
Publication date: Available online 19 July 2016 Source:Journal of Clinical Neuroscience Author(s): Joji Inamasu, Shunsuke Nakae, Tatsuo Ohmi, Hirotaka Kogame, Yushi Kawazoe, Tadashi Kumai, Riki Tanaka, Akira Wakako, Kiyonori Kuwahara, Tsukasa Ganaha, Yuichi Hirose Grade V subarachnoid haemorrhage (SAH) patients may be dichotomised into those with temporary deterioration and those with irreversible injury, and only the former have a chance of favourable outcomes by aneurysm obliteration. One method of differentiating the two conditions is to wait and observe potential recovery for 12–48hours. However, early r...
Source: Journal of Clinical Neuroscience - July 21, 2016 Category: Neuroscience Source Type: research

Bone scintigraphy as cornerstone in the diagnosis of Erdheim –Chester disease
Publication date: May–June 2016 Source:Revista Española de Medicina Nuclear e Imagen Molecular (English Edition), Volume 35, Issue 3 Author(s): F.J. García-Gómez, T. Cambil-Molina, J.J. Ríos-Martín, P.A. de la Riva-Pérez, C. Calvo-Morón, J. Castro-Montaño The Erdheim–Chester disease (ECD) is an extremely rare form of non-Langerhans cell histiocytosis. The main difficulty for its diagnosis lies in the wide variety of non-specific symptoms and signs that can occur in the disease process, leading, therefore, to there being no clear-cut algorithm as a guide for an optimal biopsy to confirm the diagnosis. An...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - July 21, 2016 Category: Nuclear Medicine Source Type: research

Aspirin or Nonsteroidal Anti-inflammatory Drug –Exacerbated Chronic Rhinosinusitis
Publication date: July–August 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 4, Issue 4 Author(s): Dennis K. Ledford, Richard F. Lockey Aspirin (ASA)-exacerbated respiratory disease (AERD) is characterized by upper airway congestion due to eosinophilic inflammation of the nasal and sinus membranes and nasal polyposis, associated with increased leukotriene production that is further accentuated by ASA or other nonsteroidal anti-inflammatory drug (NSAID) ingestion. It occurs in 5% to 10% of subjects with chronic rhinosinusitis (CRS) and in 15% to 40% of those with nasal polyposis. Altho...
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 21, 2016 Category: Allergy & Immunology Source Type: research

New aspects of controlled release systems for local anaesthetics: A  review
Publication date: Available online 17 June 2016 Source:Trends in Anaesthesia and Critical Care Author(s): Alexandru Florin Rogobete, Monica Dragomirescu, Ovidiu Horea Bedreag, Dorel Sandesc, Carmen Alina Cradigati, Mirela Sarandan, Marius Papurica, Sonia Elena Popovici, Corina Vernic, Gabriela Preda Pharmacological pain control and management applied in this medical area represent the gold goal for anaesthesia and intensive care units. One of the most common methods for pain control is the use of opioids. However, there are a number of complications and side effects induced by prolonged systemic administration ...
Source: Trends in Anaesthesia and Critical Care - July 21, 2016 Category: Anesthesiology Source Type: research

Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa –induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways
In this study, the effects of QF on Pseudomonas aeruginosa–induced acute pneumonia in mice were evaluated. The mechanisms by which four typical anti-inflammatory ingredients from QF, arctigenin (ATG), cholic acid (CLA), chlorogenic acid (CGA) and sinapic acid (SPA), regulate anti-inflammatory signaling pathways and related targets were investigated using molecular biology and molecular docking techniques. The results showed that pretreatment with QF significantly inhibits the release of cytokines (TNF-α and IL-6) and chemokines (IL-8 and RANTES), reduces leukocytes recruitment into inflamed tissues and ameliorates pulmo...
Source: Acta Pharmaceutica Sinica B - July 21, 2016 Category: Cancer & Oncology Source Type: research