Respiratory Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.
Can we improve clinical outcomes in patients with pneumonia treated with antibiotics in the intensive care unit?
Authors: Nicolau DP, Dimopoulos G, Welte T, Luyt CE Abstract Introduction Pneumonia in the intensive care unit (ICU) is associated with high morbidity, mortality and healthcare costs. However, treatment outcomes with conventional intravenous (IV) antibiotics remain suboptimal, and there is an urgent need for improved therapy options. Areas covered We review how clinical outcomes in patients with pneumonia treated in the ICU could be improved; we discuss the importance of choosing appropriate outcome measures in clinical trials, highlight the current suboptimal outcomes in patients with pneumonia, and outline potent...
Source: Expert Review of Respiratory Medicine - May 20, 2016 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Deleterious effects of incense smoke exposure on kidney function and architecture in male albino rats.
CONCLUSION: Long-term exposure to incense smoke may have deleterious effects on kidney function and architecture. Though, inhalation is the rout of exposure, findings of this study underscore that incense smoke may also have an effect on non-pulmonary tissues. PMID: 27180632 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - May 20, 2016 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research
The effects of the 5-HT2A receptor antagonist sarpogrelate hydrochloride on chronic hypoxic pulmonary hypertension in rats.
CONCLUSION: Administration of SPG ameliorated the development of CH-PH by stimulating apoptosis in and inhibiting proliferation of PASMCs. PMID: 27191897 [PubMed - as supplied by publisher] (Source: Experimental Lung Research)
Source: Experimental Lung Research - May 20, 2016 Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research
Preliminary feasibility and modelling of a liquid matrix Dictyostelium discoideum virulence assay for Pseudomonas aeruginosa.
DISCUSSION: A liquid matrix D. discoideum model for the analysis of P. aeruginosa virulence in a eukaryotic host is feasible, but further validation of the model is required before it may be employed in routine setting. PMID: 27181169 [PubMed - as supplied by publisher] (Source: British Journal of Biomedical Science)
Source: British Journal of Biomedical Science - May 20, 2016 Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
Correlation of B-type natriuretic peptide levels and echocardiographic parameters in preterm infants with patent ductus arteriosus.
CONCLUSION: BNP levels and echocardiographic parameters showed a positive correlation, but the significance of the correlations differed according to the postnatal age, especially during the first few days of life. PMID: 27186229 [PubMed] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - May 20, 2016 Category: Pediatrics Tags: Korean J Pediatr Source Type: research
Complete occlusion of the right middle cerebral artery associated with Mycoplasma pneumoniae pneumonia.
We report a case of a 5-year-old girl who developed left hemiparesis and left facial palsy, 6 days after the initiation of fever and respiratory symptoms due to pneumonia. Chest radiography, conducted upon admission, showed pneumonic infiltration and pleural effusion in the left lung field. Brain magnetic resonance imaging showed acute ischemic infarction in the right middle cerebral artery territory. Brain magnetic resonance angiography and transfemoral cerebral angiography revealed complete occlusion of the right middle cerebral artery. Mycoplasma pneumoniae infection was identified by a 4-fold increase in IgG antibodies...
Source: Korean Journal of Pediatrics - May 20, 2016 Category: Pediatrics Tags: Korean J Pediatr Source Type: research
A nationwide study of children and adolescents with pneumonia who visited Emergency Department in South Korea in 2012.
CONCLUSION: Despite the limited data due to the ED data from the NEDIS lacking laboratory results and treatment information, this study reflects well the outbreak patterns among children and adolescents with pneumonia. Our results provide a basis for future studies regarding ED treatment for children and adolescents with pneumonia. PMID: 27186220 [PubMed] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - May 20, 2016 Category: Pediatrics Tags: Korean J Pediatr Source Type: research
Antibiotic resistance of Streptococcus pneumoniae, isolated from nasopharynx of preschool children with acute respiratory tract infection in Lithuania
Increasing pneumococcal resistance to commonly used antibiotics and multidrug resistance is a serious public health concern. Data on distribution of resistant Streptococcus pneumoniae (SPn) strains among children... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - May 20, 2016 Category: Infectious Diseases Authors: Indrė Stacevičienė, Sigita Petraitienė, Daiva Vaičiūnienė, Tomas Alasevičius, Jūratė Kirslienė and Vytautas Usonis Source Type: research
Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result in congenital infection and ultimately fetal death. Little is known about immune responses to infection at the ... (Source: BMC Genomics)
Source: BMC Genomics - May 20, 2016 Category: Genetics & Stem Cells Authors: Jamie M. Wilkinson, Hua Bao, Andrea Ladinig, Linjun Hong, Paul Stothard, Joan K. Lunney, Graham S. Plastow and John C. S. Harding Source Type: research
High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: an observational cohort study
Acute respiratory failure is the main cause of admission to intensive care unit in immunocompromised patients. In this subset of patients, the beneficial effects of noninvasive ventilation (NIV) as compared to... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - May 20, 2016 Category: Intensive Care Authors: Rémi Coudroy, Angéline Jamet, Philippe Petua, René Robert, Jean-Pierre Frat and Arnaud W. Thille Source Type: research
The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction
Atherosclerosis-prone apolipoprotein E-deficient (Apoe−/−) mice display poor lipoprotein clearance with subsequent accumulation of cholesterol ester-enriched particles in the blood, which promote the development ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - May 20, 2016 Category: Research Authors: Giuseppe Lo Sasso, Walter K. Schlage, Stéphanie Boué, Emilija Veljkovic, Manuel C. Peitsch and Julia Hoeng Source Type: research
Retinopathy of prematurity in Korean infants with birthweight greater than 1500 g
Conclusion Our study confirmed that treatment-requiring ROP does occur in infants with BW >1500 g. To avoid overlooking infants with vision-threatening ROP, an evaluation of the data from larger BW preterm infants is advisable so that screening guidelines in neonatal care units may be refined. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Authors: Park, S. H., Yum, H. R., Kim, S., Lee, Y. C. Tags: Paediatrics, Ophthalmologic surgical procedures, Retina, Epidemiology Original articles - Clinical science Source Type: research
Respiratory sinus arrhythmia as a predictor of self-injurious thoughts and behaviors among adolescents
Publication date: Available online 20 May 2016 Source:International Journal of Psychophysiology Author(s): Madeline D. Wielgus, Jaclyn T. Aldrich, Amy H. Mezulis, Sheila E. Crowell Research suggests that self-injurious thoughts and behaviors (SITBs) may function as maladaptive emotion regulation strategies. One psychophysiological index of emotion regulatory capacity is respiratory sinus arrhythmia (RSA). The temporal course of RSA responsivity to a stressor may be characterized by basal RSA, RSA reactivity to stressor, and RSA recovery post-stressor. RSA has been linked to both internalizing and externalizing sympto...
Source: International Journal of Psychophysiology - May 20, 2016 Category: Psychiatry & Psychology Source Type: research
The influence of a low air pressure environment on human metabolic rate during short‐term (< 2 h) exposures
Abstract Passengers in aircraft cabins are exposed to low‐pressure environments. One of the missing links in the research on thermal comfort under cabin conditions is the influence of low air pressure on the metabolic rate. In this research, we simulated the cabin pressure regime in a chamber in which the pressure level could be controlled. Three pressure levels (101/85/70 kPa) were tested to investigate how metabolic rate changed at different pressure levels. The results show that as pressure decreased, the respiratory flow rate (RFR) at standard condition (STPD: 0°C, 101 kPa) significantly decreased. Yet the oxygen (O...
Source: Indoor Air - May 20, 2016 Category: Occupational Health Authors: W. Cui, H. Wang, T. Wu, Q. Ouyang, S. Hu, Y. Zhu Tags: Original Article Source Type: research
DCD liver transplant infection: experience from a single centre in China
ConclusionThis is the first study that offers detailed data revealing the timing and incidence of bacterial and fungal infection among adult DCD liver transplant recipients. Bacterial and fungal infection occurs at a high rate during the first week after DCD liver transplant, especially in patients with prolonged respiratory support time and renal failure, and infection is related to increased hospital stay. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - May 20, 2016 Category: Internal Medicine Authors: Z. Tu, P. Xiang, X. Xu, L. Zhou, L. Zhuang, J. Wu, W. Wang, S. Zheng Tags: Original Paper Source Type: research
Rescue of a Mouse Model of Spinal Muscular Atrophy With Respiratory Distress Type 1 by AAV9-IGHMBP2 Is Dose Dependent
Ko & Christian L Lorson (Source: Molecular Therapy)
Source: Molecular Therapy - May 20, 2016 Category: Genetics & Stem Cells Authors: Monir ShababiZhihua FengEric VillalonChristine M SibigtrothErkan Y OsmanMadeline R MillerPatricka A Williams-SimonAbby LombardiThalia H SassArleigh K AtkinsonMichael L GarciaChien-Ping KoChristian L Lorson Source Type: research
IJERPH, Vol. 13, Pages 514: Knowledge and Perceptions about Nicotine, Nicotine Replacement Therapies and Electronic Cigarettes among Healthcare Professionals in Greece
Conclusions. Greek healthcare professionals appear to overestimate the adverse effects of nicotine, and many would not recommend any nicotine-containing product as a long-term smoking substitute. Additionally, they have poor knowledge about the function and characteristics of electronic cigarettes. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - May 20, 2016 Category: Environmental Health Authors: Anastasia MoysidouKonstantinos FarsalinosVassilis VoudrisKyriakoula MerakouKallirrhoe KoureaAnastasia Barbouni Tags: Article Source Type: research
Preparation of purified perikaryal and synaptosomal mitochondrial fractions from relatively small hypothalamic brain samples
Publication date: Available online 19 May 2016 Source:MethodsX Author(s): David S. Kiss, Istvan Toth, Gergely Jocsak, Agnes Sterczer, Tibor Bartha, Laszlo V. Frenyo, Attila Zsarnovszky In order to measure the activity of neuronal mitochondria, a representative proof of neuronal processes, physiologically relevant mitochondrial samples need to be gained as simply as possible. Existing methods are, however, either for tissue samples of large size and/or homogenous microstructures only, or are not tested for mitochondrial function measurements. In the present article we describe a gradient fractionation method to iso...
Source: MethodsX - May 20, 2016 Category: Science Source Type: research
Augmentation of the Lesser Curvature With an Autologous Vascular Patch in Complex Aortic Coarctation and Interruption
Conclusions Augmenting the lesser curvature with an autologous vascular patch during arch reconstruction resulted in excellent midterm outcomes. Not only can a more natural shape of arch and less tension on the anastomosis be obtained, but complications, such as left main bronchial obstruction or recoarctation, can also be minimized. Long-term follow-up is needed to evaluate late development of recoarctation, hypertension, or aneurysm formation. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - May 20, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research
Double epigenetic modulation of high‐dose chemotherapy with azacitidine and vorinostat for patients with refractory or poor‐risk relapsed lymphoma
CONCLUSIONSDouble epigenetic modulation of Gem/Bu/Mel with azacitidine/vorinostat is feasible and highly active in patients with refractory/poor‐risk relapsed lymphomas, warranting further evaluation. Cancer 2016. © 2016 American Cancer Society. (Source: Cancer)
Source: Cancer - May 20, 2016 Category: Cancer & Oncology Authors: Yago Nieto, Benigno C. Valdez, Peter F. Thall, Roy B. Jones, Wei Wei, Alan Myers, Chitra Hosing, Sairah Ahmed, Uday Popat, Elizabeth J. Shpall, Muzaffar Qazilbash, Alison Gulbis, Paolo Anderlini, Nina Shah, Qaiser Bashir, Amin Alousi, Yasuhiro Oki, Michel Tags: Original Article Source Type: research
Response to Letter to the Editor: ‘High-frequency percussive ventilation and initial biomarker levels of lung injury after smoke inhalation – Not straightforward to interpret’
We thank R.S. Shah, M. Vizacaychipis for their thoughts about the published work and would like to describe some important points about our study of biomarkers following high frequency percussive ventilation in patients with acute respiratory failure following inhalation injury without extensive burns . (Source: Burns : Journal of the International Society for Burn Injuries)
Source: Burns : Journal of the International Society for Burn Injuries - May 20, 2016 Category: Cosmetic Surgery Authors: P. Reper, W. Heijmans Tags: Reply to Letter to the Editor Source Type: research
Development of therapeutic antibodies to G protein-coupled receptors and ion channels: Opportunities, challenges and their therapeutic potential in respiratory diseases
Publication date: Available online 3 May 2016 Source:Pharmacology & Therapeutics Author(s): Julie A. Douthwaite, Donna K. Finch, Tomas Mustelin, Trevor C.I. Wilkinson The development of recombinant antibody therapeutics continues to be a significant area of growth in the pharmaceutical industry with almost 50 approved monoclonal antibodies on the market in the US and Europe. Therapeutic drug targets such as soluble cytokines, growth factors and single transmembrane spanning receptors have been successfully targeted by recombinant monoclonal antibodies and the development of new product candidates continues. D...
Source: Pharmacology and Therapeutics - May 20, 2016 Category: Drugs & Pharmacology Source Type: research
Stridor Secondary to Acquired Subglottic Cyst: Rarity Makes it Missed
Abstract Subglottic cysts (SGCs) are a rare cause of airway obstruction in children. Medical advances, higher survival rates for preterm infants, and improved diagnostic equipment have increased the number of reported cases of SGCs over the last three decades, the majority occurring in infants who had been extremely premature neonates and had suffered from respiratory distress, therefore having been intubated and managed in neonatal ICUs. Symptoms of laryngeal cysts depend on the size and the location of the cyst and include a change in the tone of voice, dysphonia, hoarseness, dysphagia, stridor, and dyspnea. Thi...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - May 20, 2016 Category: ENT & OMF Source Type: research
Extensively drug-resistant Acinetobacter baumannii outbreak cross-transmitted in an intensive care unit and respiratory intensive care unit
Conclusions This study suggested the importance of thorough surveillance and disinfection of the environment, including concealed devices, in preventing the transmission of an outbreak. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - May 20, 2016 Category: Infectious Diseases Source Type: research
MERS-interpreted: human herpesvirus 6B pneumonia
A patient’s symptoms and travel history suggested that he might be suffering from Middle East respiratory syndrome or MERS, a frightening, and often fatal viral infection. The man, who was 44 years old and Caucasian, presented to the hospital with a 2-day history of fever and dry cough. He also complained of sore throat, headache, and mild epigastric discomfort. In addition, he had noticed a skin rash on the day of admission. He returned from a business trip to the United Arab Emirates 10 days earlier, but he recalled no contact with animals or sick people. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - May 20, 2016 Category: Journals (General) Authors: Susanna K.P. Lau, Jasper F.W. Chan, Ivan F.N. Hung, Vincent C.C. Cheng, Siddharth Sridhar, Cyril C.Y. Yip, Kwok-Hung Chan, Patrick C.Y. Woo Tags: Diagnostic Dilemma Source Type: research
Testing the hypothesis of neurodegeneracy in respiratory network function with a priori transected arterially perfused brain stem preparation of rat
Degeneracy of respiratory network function would imply that anatomically discrete aspects of the brain stem are capable of producing respiratory rhythm. To test this theory we a priori transected brain stem preparations before reperfusion and reoxygenation at 4 rostrocaudal levels: 1.5 mm caudal to obex (n = 5), at obex (n = 5), and 1.5 (n = 7) and 3 mm (n = 6) rostral to obex. The respiratory activity of these preparations was assessed via recordings of phrenic and vagal nerves and lumbar spinal expiratory motor output. Preparations with a priori transection at level of the caudal brain stem did not produce stable rhythmi...
Source: Journal of Neurophysiology - May 20, 2016 Category: Neurology Authors: Jones, S. E., Dutschmann, M. Tags: Neural Circuits Source Type: research
A population study of respiratory rehospitalisation in very preterm infants in the first 3 years of life
ConclusionsRespiratory rehospitalisations are common in very premature survivors. Home oxygen and indigenous status are significant risk factors for respiratory and RSV‐related rehospitalisations. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - May 20, 2016 Category: Pediatrics Authors: Timothy Hong, Srinivas Bolisetty, Barbara Bajuk, Mohamed Abdel‐Latif, Julee Oei, Adam Jaffe, Kei Lui Tags: Original Article Source Type: research
Pediatric Pulmonary Infections
Respiratory infection is the most common cause for hospital admission and the second most common reason for emergency room visits among children.1, 2 Viral, bacterial, mycobacterial, and fungal pulmonary infections in children may have unique radiologic findings, distinct from adults. In addition, normal anatomic structures and neoplasms are common mimics of pulmonary infections in the pediatric population. The article focuses on up to date review on pulmonary infections in children. (Source: Seminars in Roentgenology)
Source: Seminars in Roentgenology - May 20, 2016 Category: Radiology Authors: Abbey Winant, Gary Schooler, Nathan David P. Concepcion, Edward Y. Lee Source Type: research
Effects of Respiratory Muscle Training on Respiratory Function, Respiratory Muscle Strength and Exercise Tolerance in Post-Stroke Patients: A Systematic Review with Meta-Analysis
We performed a systematic review and meta-analysis to examine the effects of respiratory muscle training on respiratory function, respiratory muscle strength and exercise tolerance in post-stroke patients. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - May 20, 2016 Category: Rehabilitation Authors: Mansueto Gomes-Neto, Micheli Bernardone Saquetto, Cassio Magalhães Silva, Vitor Oliveira Carvalho, Nildo Ribeiro, Cristiano Sena Conceição Source Type: research
Frequency of comorbidities in chronic obstructive pulmonary disease, and impact on all-cause mortality: A population based cohort study
In chronic obstructive pulmonary disease (COPD), the role of specific comorbidities on all-cause mortality is of major interest particularly with a database representative of the beneficiaries covered by the French health system. We investigated the frequency and the role of major comorbidities on all-cause mortality in a population-based cohort of COPD patients, and whether this impact was modulated by gender. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 20, 2016 Category: Respiratory Medicine Authors: Laurent Laforest, Nicolas Roche, Gilles Devouassoux, Manon Belhassen, Christos Chouaid, Marine Ginoux, Eric Van Ganse Source Type: research
Pleural effusion cytology due to malignancy. A combined cytomorphological–immunocytochemical study of 500 cases
Publication date: Available online 20 May 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): A. Kalogeraki, D. Tamiolakis, G. Datseri, G. Lazopoulos, M. Karvelas-Kalogerakis, J. Segredakis, I. Zoi (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - May 20, 2016 Category: Respiratory Medicine Source Type: research
Spinal fusion for pediatric neuromuscular scoliosis: national trends, complications, and in-hospital outcomes.
CONCLUSIONS Increasing use of IONM and posterior-only approaches may combat the high complication rates in NMS. The trends of increasing comorbidities, blood transfusions, and total costs in spinal fusion surgery for pediatric NMS may indicate an increasingly aggressive approach to these cases. PMID: 27203810 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - May 20, 2016 Category: Neurosurgery Authors: Rumalla K, Yarbrough CK, Pugely AJ, Koester L, Dorward IG Tags: J Neurosurg Spine Source Type: research
The role of vagal pathway and NK1 and NK2 receptors in cardiorespiratory effects of neurokinin A.
This article is protected by copyright. All rights reserved. PMID: 27199181 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - May 20, 2016 Category: Drugs & Pharmacology Authors: Kaczyńska K, Jampolska M, Szereda-Przestaszewska M Tags: Clin Exp Pharmacol Physiol Source Type: research
Neuroinvasive influenza virus A(H5N8) in fattening ducks, Hungary, 2015.
Abstract Highly pathogenic avian influenza (HPAI) A virus H5N8 was detected in far east Asian countries during 2014 and emerged in late 2014 in European countries. Hungary reported a HPAI A(H5N8) outbreak during late winter of 2015 at a Pekin duck fattening facility. Epidemiologic monitoring was extended to holdings in neighboring areas and nearby habitats used by wild birds but failed to identify the source of infection. In addition to respiratory symptoms, the affected birds showed lethargy and neuronal signs, including torticollis. Consistent with this finding, influenza A virus antigen was detected in large qua...
Source: Infection, Genetics and Evolution - May 20, 2016 Category: Genetics & Stem Cells Authors: Bányai K, Bistyák AT, Thuma Á, Gyuris É, Ursu K, Marton S, Farkas SL, Hortobágyi E, Bacsadi Á, Dán Á Tags: Infect Genet Evol Source Type: research
Acute toxicity, biochemical and histopathological responses of endosulfan in Chanos chanos.
This study investigated 96h median lethal concentration of endosulfan (99%, pure α: β ratio of 7:3) by conducting static non-renewable acute toxicity bio-assay in Chanos chanos juvenile with average weight (110±5.65g). Further, the effect of different definitive doses (18.5, 19.5, 20.5, 21.5 and 22.5µg/L) of endosulfan on metabolic, heamato-immunoligcal and histopathological response were probed. Anti-oxidative enzymes CAT, SOD and GST showed significant (p<0.01) increase of activity in the liver, gill and brain during exposure to endosulfan in a dose and time dependent manner. The brain AChE activity showed signifi...
Source: Ecotoxicology and Environmental Safety - May 20, 2016 Category: Environmental Health Authors: Kumar N, Ambasankar K, Krishnani KK, Gupta SK, Bhushan S, Minhas PS Tags: Ecotoxicol Environ Saf Source Type: research
Effects of Respiratory Muscle Training on Respiratory Function, Respiratory Muscle Strength and Exercise Tolerance in Post-Stroke Patients: A Systematic Review with Meta-Analysis.
CONCLUSIONS: Respiratory muscle training should be considered an effective method of improving respiratory function, inspiratory muscle strength, and exercise tolerance in post-stroke patients. Further research is needed to determine optimum dosages and duration of effect. PMID: 27216224 [PubMed - as supplied by publisher] (Source: Physica Medica)
Source: Physica Medica - May 20, 2016 Category: Physics Authors: Gomes-Neto M, Saquetto MB, Silva CM, Carvalho VO, Ribeiro N, Conceição CS Tags: Arch Phys Med Rehabil Source Type: research
Reliable quantification of rhinovirus species C using real-time PCR.
Abstract BACKGROUND: Rhinovirus C (RV-C) is an important respiratory pathogen of children, but little is known about its contribution to disease severity, though viral load appears to be important. Difficulty in RV-C cultivation and target sequence variation has precluded the development of a PCR based quantification method. OBJECTIVE: The aim of this study was to develop and validate reverse transcription quantitative PCR (RT-qPCR) assays for a broad range of circulating RV-C genotypes in nasopharyngeal aspirates (NPAs). STUDY DESIGN: Four assays were designed to quantify a 296bp region located within the ...
Source: Journal of Virological Methods - May 20, 2016 Category: Virology Authors: Sikazwe CT, Chidlow GR, Imrie A, Smith DW Tags: J Virol Methods Source Type: research
Effectiveness of seasonal trivalent influenza vaccination against hospital-attended acute respiratory infections in pregnant women: A retrospective cohort study.
CONCLUSIONS: Influenza vaccination during pregnancy was associated with significantly fewer hospital attendances for ARI in pregnant women. PMID: 27216758 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - May 20, 2016 Category: Allergy & Immunology Authors: Regan AK, Klerk N, Moore HC, Omer SB, Shellam G, Effler PV Tags: Vaccine Source Type: research
Abrasion plus local fibrin sealant instillation produces pleurodesis similar to pleurectomy in rabbits.
CONCLUSIONS: Abrasion with local fibrin sealant instillation is as effective as pleurectomy in producing pleurodesis in rabbits. Apical pleurectomy elicits a more persistent elevation of serum IL-8 levels than apical abrasion alone or abrasion plus fibrin adhesive instillation. PMID: 27217265 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - May 20, 2016 Category: Respiratory Medicine Authors: Marchi E, de Carvalho MV, Ventureli TR, Fruchi AJ, Lazaro A, do Carmo DC, Barreto TY, Dias BV, Acencio MM, Teixeira LR, Light RW Tags: Chest Source Type: research
Asian Dust and Pediatric Emergency Department Visits Due to Bronchial Asthma and Respiratory Diseases in Nagasaki, Japan.
CONCLUSIONS: The study findings suggested that AD exposure increases emergency department visits by children. PMID: 27180931 [PubMed - as supplied by publisher] (Source: Journal of Epidemiology)
Source: Journal of Epidemiology - May 19, 2016 Category: Epidemiology Tags: J Epidemiol Source Type: research
Pediatric Sarcomas Are Targetable by MR‐Guided High Intensity Focused Ultrasound (MR‐HIFU): Anatomical Distribution and Radiological Characteristics
ConclusionsMany pediatric sarcomas are localized at diagnosis and are targetable by current MR‐HIFU technology. Some children with neuroblastoma have bony tumors targetable by MR‐HIFU at relapse, but few newly diagnosed children with neuroblastoma have tumors amenable to MR‐HIFU therapy. Clinical trials of MR‐HIFU should focus on patients with anatomically targetable tumors. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - May 19, 2016 Category: Cancer & Oncology Authors: Jenny Shim, Robert M. Staruch, Korgun Koral, Xian‐Jin Xie, Rajiv Chopra, Theodore W. Laetsch Tags: Research Article Source Type: research
Moving towards a new vision: implementation of a public health policy intervention.
CONCLUSIONS: Multiple factors influenced public health policy implementation. Results provide empirical support for components of Greenhalgh et al's framework and suggest two additional components - the role of external organizational collaborations and partnerships as well as planning processes in influencing implementation. These are important to consider by government and public health organizations when promoting new or revised public health policies as they evolve over time. A successful policy implementation process in Ontario has helped to move public health towards the new vision. PMID: 27185039 [PubMed - in pr...
Source: Rural Remote Health - May 19, 2016 Category: Rural Health Authors: Valaitis R, MacDonald M, Kothari A, O'Mara L, Regan S, Garcia J, Murray N, Manson H, Peroff-Johnston N, Bursey G, Boyko J Tags: BMC Public Health Source Type: research
Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.
Abstract The trimeric intracellular cation (TRIC) channels TRIC-A and TRIC-B localize predominantly to the endoplasmic reticulum (ER) and likely support Ca(2+) release from intracellular stores by mediating cationic flux to maintain electrical neutrality. Deletion and point mutations in TRIC-B occur in families with autosomal recessive osteogenesis imperfecta. Tric-b knockout mice develop neonatal respiratory failure and exhibit poor bone ossification. We investigated the cellular defect causing the bone phenotype. Bone histology indicated collagen matrix deposition was reduced in Tric-b knockout mice. Osteoblasts,...
Source: Science Signaling - May 19, 2016 Category: Biomedical Science Authors: Zhao C, Ichimura A, Qian N, Iida T, Yamazaki D, Noma N, Asagiri M, Yamamoto K, Komazaki S, Sato C, Aoyama F, Sawaguchi A, Kakizawa S, Nishi M, Takeshima H Tags: Sci Signal Source Type: research
Predictors of deterioration of lung function in Polish children with cystic fibrosis.
CONCLUSIONS: The presence of MI, IGT, chronic PA colonization, and number of exacerbations are risk factors for lung function deterioration. PMID: 27186187 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 19, 2016 Category: Journals (General) Tags: Arch Med Sci Source Type: research
Postoperative Subconjunctival Emphysema
A 68-year-old man was admitted for incidental radiological finding of a positron emission tomography (PET) positive left upper pulmonary nodule. The patient underwent thoracoscopic resection of the nodule and an intraoperative frozen section did not reveal malignant tumor cells. On postoperative day 2, during daily respiratory physiotherapy, the patient developed massive subcutaneous emphysema of the upper trunk, neck, and face. On physical examination, bilateral subconjunctival emphysema was clearly evident (Fig 1). (Source: Ophthalmology)
Source: Ophthalmology - May 19, 2016 Category: Opthalmology Authors: Luca Ampollini, Luigi Ventura, Paolo Carbognani Tags: Pictures & Perspectives Source Type: research
Economic impact of recurrent respiratory papillomas in a UK adult population.
CONCLUSION: Recurrent respiratory papilloma is a benign condition, but the financial implications of diagnosis are significant. Recurrent respiratory papilloma has a natural history of relapse and remission, and patients may require healthcare input over a period of several years. PMID: 27188701 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - May 19, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
Route complexity and simulated physical ageing negatively influence wayfinding.
Abstract The aim of this age-simulation field experiment was to assess the influence of route complexity and physical ageing on wayfinding. Seventy-five people (aged 18-28) performed a total of 108 wayfinding tasks (i.e., 42 participants performed two wayfinding tasks and 33 performed one wayfinding task), of which 59 tasks were performed wearing gerontologic ageing suits. Outcome variables were wayfinding performance (i.e., efficiency and walking speed) and physiological outcomes (i.e., heart and respiratory rates). Analysis of covariance showed that persons on more complex routes (i.e., more floor and building ch...
Source: Applied Ergonomics - May 19, 2016 Category: Occupational Health Authors: Zijlstra E, Hagedoorn M, Krijnen WP, van der Schans CP, Mobach MP Tags: Appl Ergon Source Type: research
Microvascular reactivity is altered early in patients with acute respiratory distress syndrome.
CONCLUSIONS: In ARDS patients, microvascular reactivity is altered early, and the changes are directly related to the severity of the disease. The ascending slope is the best determinant of outcome. PMID: 27188409 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 19, 2016 Category: Respiratory Medicine Authors: Orbegozo Cortés D, Rahmania L, Irazabal M, Santacruz C, Fontana V, De Backer D, Creteur J, Vincent JL Tags: Respir Res Source Type: research