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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Investigation of Lung Involvement in Connective Tissue Disorders
Lung involvement in connective tissue disorders (CTDs) may present as pleomorphic since any lung compartment may be involved such as airways, exocrine secretory and alveolar epithelia, interstitial lung structure, pulmonary vasculature and pleura as well as, in specific disorders, several tissues of the thoracoabdominal ventilator pump. Any combination of the above anatomic structures may be involved concomitantly although some specific combinations may include a determinant of rheumatic disorders. The diagnosis of a specific CTD requires the fulfilment of clearly defined clinical and laboratory criteria including in most ...
Source: Respiration - June 27, 2015 Category: Respiratory Medicine Source Type: research

Noninvasive Ventilation in the Treatment of Severe Community-Acquired Pneumonia: The Experience of a Single Center
Conclusions: Noninvasive ventilation success is related to a strict selection and monitoring of patients. Similar NIV-failure rates were observed in patients with de novo and previous cardiac or respiratory disease. There are clinical parameters that predict NIV failure and mortality. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - June 27, 2015 Category: Infectious Diseases Tags: Original Articles Source Type: research

Potential systematic uncertainties in IGRT when FBCT reference images are used for pancreatic tumors.
Abstract The purpose of this study was to quantify the systematic uncertainties resulting from using free breathing computed tomography (FBCT) as a reference image for image-guided radiation therapy (IGRT) for patients with pancreatic tumors, and to quantify the associated dosimetric impact that resulted from using FBCT as reference for IGRT. Fifteen patients with implanted fiducial markers were selected for this study. For each patient, a FBCT and an average intensity projection computed tomography (AIP) created from four-dimensional computed tomography (4D CT) were acquired at the simulation. The treatment plan w...
Source: Journal of Applied Clinical Medical Physics - June 27, 2015 Category: Physics Authors: Amoush A, Abdel-Wahab M, Abazeed M, Xia P Tags: J Appl Clin Med Phys Source Type: research

Helical 4D CT pitch management for the Brilliance CT Big Bore in clinical practice.
Abstract In external beam radiotherapy treatment planning for patients with thoracic malignancies, respiratory-correlated CT (4D CT) is used to obtain high quality studies in the presence of respiratory motion. When helical 4D CT scans are acquired with a Brilliance CT Big Bore, the pitch must meet two conditions. It must be low enough to avoid motion artifacts, and high enough to cover the entire scan length within 120 s to prevent overheating of the X-ray tube. We developed a nomogram that can be used to obtain a suitable pitch satisfying both requirements. We also assessed the effects on the image quality of a p...
Source: Journal of Applied Clinical Medical Physics - June 27, 2015 Category: Physics Authors: Hilgers G, Nuver T, Minken A Tags: J Appl Clin Med Phys Source Type: research

Evaluation of 4D CT acquisition methods designed to reduce artifacts.
Abstract Four-dimensional computed tomography (4D CT) is used to account for respiratory motion in radiation treatment planning, but artifacts resulting from the acquisition and postprocessing limit its accuracy. We investigated the efficacy of three experimental 4D CT acquisition methods to reduce artifacts in a prospective institutional review board approved study. Eighteen thoracic patients scheduled to undergo radiation therapy received standard clinical 4D CT scans followed by each of the alternative 4D CT acquisitions: 1) data oversampling, 2) beam gating with breathing irregularities, and 3) rescanning the c...
Source: Journal of Applied Clinical Medical Physics - June 27, 2015 Category: Physics Authors: Castillo SJ, Castillo R, Castillo E, Pan T, Ibbott G, Balter P, Hobbs B, Guerrero T Tags: J Appl Clin Med Phys Source Type: research

Technical evaluation of different respiratory monitoring systems used for 4D CT acquisition under free breathing.
Abstract tion on the patient's breathing during the acquisition of a respiration-correlated computer tomography (RCCT), also referred to as 4D CT. The information a respiratory monitoring system has to provide to the CT scanner depends on the specific scanner. The purpose of this study is to compare two different respiratory monitoring systems (Anzai Respiratory Gating System; C-RAD Sentinel) with respect to their applicability in combination with an Aquilion Large Bore CT scanner from Toshiba. The scanner used in our clinic does not make use of the full time dependent breathing signal, but only single trigger puls...
Source: Journal of Applied Clinical Medical Physics - June 27, 2015 Category: Physics Authors: Heinz C, Reiner M, Belka C, Walter F, Söhn M Tags: J Appl Clin Med Phys Source Type: research

Evidence supporting the need for considering the effects of smoking on drug disposition and effectiveness in medication practices: a systematic narrative review.
This study was conducted to provide a narrative overview of interactions between smoking and drug effectiveness/ pharmacokinetics. Database searches were performed to identify review articles published prior to March 10, 2013. Eligible articles reporting altered pharmacokinetic profiles, drug response, or adverse drug effects due to drug-smoking interactions were selected. Information on mechanism of action and clinical effects from the selected articles (n = 83) were summarized by therapeutic drug class. For cardiovascular drugs, smoking effects were variable. Smoking reduced aspirin response but increased clopidogrel res...
Source: International Journal of Clinical Pharmacology and Therapeutics - June 27, 2015 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

A 2015 Update on Ventilator-Associated Pneumonia: New Insights on Its Prevention, Diagnosis, and Treatment
Abstract Ventilator-associated pneumonia (VAP), an infection of the lower respiratory tract which occurs in association with mechanical ventilation, is one of the most common causes of nosocomial infection in the intensive care unit (ICU). VAP causes significant morbidity and mortality in critically ill patients including increased duration of mechanical ventilation, ICU stay and hospitalization. Current knowledge for its prevention, diagnosis and management is therefore important clinically and is the basis for this review. We discuss recent changes in VAP surveillance nomenclature incorporating ventilator-assoc...
Source: Current Infectious Disease Reports - June 27, 2015 Category: Infectious Diseases Source Type: research

Frequency domain analysis of cerebral near infrared spectroscopy signals during application of an impedance threshold device in spontaneously ventilating volunteers
Abstract Currently available near infrared spectroscopy (NIRS) devices are unable to discriminate between arterial and venous blood, a potential source of artifact. The purpose of this study was to test the hypothesis that oscillations in NIR signals at the respiratory and cardiac frequency could be attributed to venous and arterial blood, respectively, and thereby isolated. After written informed consent was obtained, a two-wavelength NIRS device was placed over the left frontal cortex in 20 volunteers. After 5 min of unimpeded spontaneous ventilation, an impedance threshold device (ITD, average resistance—7 ...
Source: Journal of Clinical Monitoring and Computing - June 27, 2015 Category: Information Technology Source Type: research

Neonatal respiratory distress syndrome revealing a cervical bronchogenic cyst: a case report
Conclusion: A bronchogenic cyst can exceptionally obstruct the airways in the neonatal period. Surgical excision is necessary, but postoperative complications may occur if the cyst is in close contact with the trachea and esophagus, including necrotic and stenotic lesions of the upper aerodigestive tract. In those situations, tracheostomy may be necessary for mechanical ventilation weaning and the initiation of oral feeding. (Source: BMC Pediatrics)
Source: BMC Pediatrics - June 27, 2015 Category: Pediatrics Authors: Penelope ThallerCatherine BlanchetMaliha BadrRenaud MesnageNicolas LeboucqMichel MondainGilles Cambonie Source Type: research

The prevalence of sleep-disordered breathing among survivors of acute pulmonary embolism
Conclusion OSA is a common comorbidity of PE and possibly represents an additional risk factor for hemodynamic instability in PE patients. (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 27, 2015 Category: Respiratory Medicine Source Type: research

The effect of partial sleep deprivation on computer-based measures of fitness to drive
Conclusion In contrast to established tests of sustained attention and subjective sleepiness, computer-based test batteries of fitness to drive might lack sensitivity to core aspects of sleepiness as they mainly consist of short and stimulating subtests. Therefore, tasks that require sustained attention should be an essential part of traffic psychological test batteries when sleepiness is a potential issue. (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 27, 2015 Category: Respiratory Medicine Source Type: research

Maintaining Gains Following Pulmonary Rehabilitation
Conclusions This study confirms that many of the functional gains achieved in PR are lost in the longer term. Regular surveillance or monitoring of these patients post-PR is important to identify those requiring further intervention. (Source: Lung)
Source: Lung - June 27, 2015 Category: Respiratory Medicine Source Type: research

Protective effect of a Protein Epitope Mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation
Conclusions: The Protein Epitope Mimetic CCR10 antagonist, POL7085, significantly and dose-dependently decreased allergen-induced airway hyperresponsiveness and airway inflammation after once daily local treatment. Our data give strong support for further investigations with CCR10 antagonists in asthmatic disease. (Source: Respiratory Research)
Source: Respiratory Research - June 27, 2015 Category: Respiratory Medicine Authors: François DaubeufFrançoise JungGarry DouglasEric ChevalierNelly Frossard Source Type: research

Non-invasive pulmonary function test on Morquio patients
Publication date: Available online 23 June 2015 Source:Molecular Genetics and Metabolism Author(s): Francyne Kubaski , Shunji Tomatsu , Pravin Patel , Tsutomu Shimada , Li Xie , Eriko Yasuda , Robert Mason , William G. Mackenzie , Mary Theroux , Michael B. Bober , Helen M. Oldham , Tadao Orii , Thomas H. Shaffer In clinical practice, respiratory function tests are difficult to perform in Morquio syndrome patients due to their characteristic skeletal dysplasia, small body size and lack of cooperation of young patients, where in some cases, conventional spirometry for pulmonary function is too challenging. To establish fea...
Source: Molecular Genetics and Metabolism - June 27, 2015 Category: Genetics & Stem Cells Source Type: research

Shp‐2 contributes to anti‐RSV activity in human pulmonary alveolar epithelial cells by interfering with the IFN‐α‐induced Jak/Stat1 pathway
In this study, we investigated the role of Shp‐2 in the host cell interactions of human respiratory syncytial virus (RSV). We report significant changes in the expression of Shp‐2 in human pulmonary alveolar epithelial cells (A549) upon RSV infection. We also report that blocking Shp‐2 does not affect viral replication or virus‐induced interferon‐alpha (IFN‐α) production. Interestingly, whereas A549 cells were activated by IFN‐α, the blocking of Shp‐2 resulted in increased viral replication that was associated with the reduced expression of the IFN‐stimulated genes of 2′,5′‐oligoadenylate syntheta...
Source: Journal of Cellular and Molecular Medicine - June 27, 2015 Category: Molecular Biology Authors: Saisai Wang, Gang Zheng, Lifang Zhao, Feng Xu, Jing Qian Tags: Original Article Source Type: research

Chronic Pain, Comorbid Medical Conditions, and Associated Risk Factors in Kuwait: Gender and Nationality Differences
ConclusionsThis extensive survey study that found female Kuwaitis to have a higher incidence of pain and medical comorbidities than males and non‐Kuwaitis highlights the role of cultural factors in contributing to pain and comorbid medical conditions. This information is critical in organizing resources to implement adequate healthcare services and behavioral interventions in Kuwait and other Arab countries to improve pain and health‐related conditions. (Source: Pain Medicine)
Source: Pain Medicine - June 27, 2015 Category: Anesthesiology Authors: Maureen C. Deeny, Elham Al Hamdan, Edgar L. Ross, Robert R. Edwards, Chuan‐Chin Huang, Robert N. Jamison Tags: Original Source Type: research

Management of Right Heart Failure in the Intensive Care Unit
Right heart failure is a clinical syndrome of various causes that commonly involves failure of the right ventricle (RV). The hemodynamic hallmark of the syndrome is increasing central venous pressure and worsening cardiac output with a rising RV end-diastolic pressure. When dealing with RV failure, clinicians must assess and optimize the intravascular volume state, support RV contractility, and address any pathologic elevations of afterload so that systemic perfusion is preserved. Despite these measures, there may still be a need to offer rescue interventions to the failing RV in carefully selected patients. (Source: Clini...
Source: Clinics in Chest Medicine - June 27, 2015 Category: Respiratory Medicine Authors: Cyrus A. Kholdani, Wassim H. Fares Source Type: research

Integration of Palliative Care Services in the Intensive Care Unit
This article discusses the benefits and barriers to integration of ICU and palliative care services, and a stepwise approach to implementation of palliative care services. Integration of palliative care services into ICU workflow is increasingly seen as essential to providing high-quality, comprehensive critical care. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - June 27, 2015 Category: Respiratory Medicine Authors: Mary Baker, Jim Luce, Gabriel T. Bosslet Source Type: research

Adverse Event Reporting and Quality Improvement in the Intensive Care Unit
Patients in the intensive care unit are at high risk for experiencing adverse events and errors. The high-acuity health care needs of these vulnerable patients expose them to numerous medications, procedures, and health care providers. The occurrence of adverse events is associated with detriments to patient outcomes including increased mortality. Adverse event reporting is the most commonly used event-detection tool, but it should also be complimented with other tools such as trigger tools, chart review, and direct observation. Although adverse event reporting is essential for continuous improvement processes and is assoc...
Source: Clinics in Chest Medicine - June 27, 2015 Category: Respiratory Medicine Authors: Jason J. Heavner, Jonathan M. Siner Source Type: research

ICU Telemedicine Solutions
During the last 15 years, critical care services provided via telemedicine have expanded to now be incorporated into the care of 13% of patients in intensive care units (ICUs) in the United States. A response to shortfalls in the availability of critical care–trained providers has evolved into integrated programs of ICU care with contributions to improved outcomes through proactive management, population oversight, and standardization of care processes. The most impactful characteristics of successful ICU telemedicine programs are now better understood with more than a decade of national experience and the accrued benef...
Source: Clinics in Chest Medicine - June 27, 2015 Category: Respiratory Medicine Authors: Steven A. Fuhrman, Craig M. Lilly Source Type: research

Shp-2 contributes to anti-RSV activity in human pulmonary alveolar epithelial cells by interfering with the IFN-α-induced Jak/Stat1 pathway.
In this study, we investigated the role of Shp-2 in the host cell interactions of human respiratory syncytial virus (RSV). We report significant changes in the expression of Shp-2 in human pulmonary alveolar epithelial cells (A549) upon RSV infection. We also report that blocking Shp-2 does not affect viral replication or virus-induced interferon-alpha (IFN-α) production. Interestingly, whereas A549 cells were activated by IFN-α, the blocking of Shp-2 resulted in increased viral replication that was associated with the reduced expression of the IFN-stimulated genes of 2',5'-oligoadenylate synthetases and Mx1, and the con...
Source: J Cell Mol Med - June 27, 2015 Category: Molecular Biology Authors: Wang S, Zheng G, Zhao L, Xu F, Qian J Tags: J Cell Mol Med Source Type: research

Propidium monoazide (PMA) and ethidium bromide monoazide (EMA) improve DNA array and high-throughput sequencing of porcine reproductive and respiratory syndrome virus identification.
Abstract Pan-viral DNA array (PVDA) and high-throughput sequencing (HTS) are useful tools to identify novel viruses of emerging diseases. However, both techniques have difficulties to identify viruses in clinical samples because of the host genomic nucleic acid content (hg/cont). Both propidium monoazide (PMA) and ethidium bromide monoazide (EMA) have the capacity to bind free DNA/RNA, but are cell membrane-impermeable. Thus, both are unable to bind protected nucleic acid such as viral genomes within intact virions. However, EMA/PMA modified genetic material cannot be amplified by enzymes. In order to assess the po...
Source: Journal of Virological Methods - June 27, 2015 Category: Virology Authors: Bellehumeur C, Boyle B, Charette SJ, Harel J, L'Homme Y, Masson L, Gagnon CA Tags: J Virol Methods Source Type: research

Reduced airway microbiota diversity is associated with elevated allergic respiratory inflammation
An increased prevalence of allergic disorders in developed countries has been associated with decreased exposure to environmental micro-organisms and an alteration of microbiota colonization. An appropriate model is needed to investigate the mechanisms by which hygiene environment-driven changes in microbiota could regulate allergic disorders. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - June 26, 2015 Category: Allergy & Immunology Authors: Wenkai Yu, Xiaopeng Yuan, Xingche Xu, Rui Ding, Liyuan Pang, Yinhui Liu, Yanjie Guo, Huajun Li, Ming Li, Jieli Yuan, Li Tang, Shu Wen Tags: Original article Source Type: research

Vitamin D and asthma: current perspectives
Purpose of review: To review the current evidence on the relationship between vitamin D and asthma. Recent findings: The rising morbidity and tremendous socioeconomic burden of asthma have prompted efforts to seek modifiable environmental and nutritional factors that contribute to the asthma epidemic. The association between low levels of vitamin D and asthma has been supported by many, but not all observational and epidemiologic studies. Recently, several controlled clinical trials have been undertaken to explore the effect of vitamin D supplementation on asthma control and respiratory tract infections. While some trials ...
Source: Current Opinion in Allergy and Clinical Immunology - June 26, 2015 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by David A. Khan and Enrico Compalati Source Type: research

Cysteine scanning reveals minor local rearrangements of the horizontal helix of respiratory complex I
Summary The NADH:ubiquinone oxidoreductase, respiratory complex I, couples electron transfer from NADH to ubiquinone with the translocation of protons across the membrane. The complex consists of a peripheral arm catalyzing the redox reaction and a membrane arm catalyzing proton translocation. The membrane arm is almost completely aligned by a 110 Å unique horizontal helix that is discussed to transmit conformational changes induced by the redox reaction in a piston‐like movement to the membrane arm driving proton translocation. Here, we analyzed such a proposed movement by cysteine‐scanning of the helix of the Escher...
Source: Molecular Microbiology - June 26, 2015 Category: Microbiology Authors: Stefan Steimle, Christian Schnick, Eva‐Maria Burger, Franziska Nuber, Dorothée Krämer, Hannah Dawitz, Sofia Brander, Bartlomiej Matlosz, Jacob Schäfer, Katharina Maurer, Udo Glessner, Thorsten Friedrich Tags: Research Article Source Type: research

Predicting neonatal respiratory morbidity by lamellar body count and gestational age
Journal Name: Journal of Perinatal MedicineIssue: Ahead of print (Source: Journal of Perinatal Medicine)
Source: Journal of Perinatal Medicine - June 26, 2015 Category: Perinatology & Neonatology Source Type: research

A case report of short-chain acyl-CoA dehydrogenase deficiency (SCADD).
CONCLUSIONS: In our case clinical features of a patient, biochemical parameters and genetic data were consistent and showed definitely SCAD deficiency. PMID: 26110041 [PubMed - in process] (Source: Biochemia Medica)
Source: Biochemia Medica - June 26, 2015 Category: Biochemistry Tags: Biochem Med (Zagreb) Source Type: research

Multiplexed detection of viral infections using rapid in situ RNA analysis on a chip
Lab Chip, 2015, Advance ArticleDOI: 10.1039/C5LC00459D, PaperSydney M. Shaffer, Rohan P. Joshi, Benjamin S. Chambers, David Sterken, Andrew G. Biaesch, David J. Gabrieli, Yang Li, Kristen A. Feemster, Scott E. Hensley, David Issadore, Arjun RajThis paper presents an automated platform for ultra rapid detection of respiratory viruses using RNA FISH.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - June 26, 2015 Category: Chemistry Authors: Sydney M. Shaffer Source Type: research

Exhaled Breath Condensate: Technical and Diagnostic Aspects.
Conclusions. There is rapidly increasing number of innovative articles, covering all the areas of modern respiratory medicine and expanding EBC potential clinical applications to other fields of internal medicine. However, the majority of published papers represent the results of small-scale studies and thus current knowledge must be further evaluated in large cohorts. In regard to the potential clinical use of EBC-analysis, several limitations must be pointed out, including poor reproducibility of biomarkers and absence of large surveys towards determination of reference-normal values. In conclusion, contemporary EBC-anal...
Source: The Scientific World Journal - June 26, 2015 Category: Science Tags: ScientificWorldJournal Source Type: research

Neuromuscular Disorders and Sleep in Critically Ill Patients
Sleep-disordered breathing (SDB) is a frequent presenting manifestation of neuromuscular disorders and can lead to significant morbidity and mortality. If not recognized and addressed early in the clinical course, SDB can lead to clinical deterioration with respiratory failure. The pathophysiologic basis of SDB in neuromuscular disorders, clinical features encountered in specific neuromuscular diseases, and diagnostic and management strategies for SDB in neuromuscular patients in the critical care setting are reviewed. Noninvasive positive pressure ventilation has been a crucial advance in critical care management, improvi...
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Muna Irfan, Bernardo Selim, Alejandro A. Rabinstein, Erik K. St. Louis Source Type: research

Noninvasive Ventilation in Critically Ill Patients
This article provides physicians and respiratory therapists with a comprehensive, practical guideline for using NIV in critical care. (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Cesare Gregoretti, Lara Pisani, Andrea Cortegiani, Vito Marco Ranieri Source Type: research

Seinäjoki Adult Asthma Study (SAAS): a protocol for a 12-year real-life follow-up study of new-onset asthma diagnosed at adult age and treated in primary and specialised care.
PMID: 26110580 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - June 26, 2015 Category: Respiratory Medicine Authors: Kankaanranta H, Ilmarinen P, Kankaanranta T, Tuomisto LE Tags: NPJ Prim Care Respir Med Source Type: research

Balance Training in Pulmonary Rehabilitation: EFFECTS ON PSYCHOSOCIAL OUTCOMES.
CONCLUSIONS: Balance training added to PR improved health-related QOL, fatigue, and mental health in patients with COPD. PMID: 26110625 [PubMed - as supplied by publisher] (Source: Journal of Cardiopulmonary Rehabilitation and Prevention)
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - June 26, 2015 Category: Rehabilitation Authors: Mkacher W, Mekki M, Chaieb F, Tabka Z, Trabelsi Y Tags: J Cardiopulm Rehabil Prev Source Type: research

Expert consensus on image-guided radiofrequency ablation of pulmonary tumors-2015 edition.
Authors: Liu BD, Zhi XY PMID: 26101663 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The AME Special Competition 2015: 4 rounds, 27 contestants, countless lessons learned about China.
Authors: Sihoe AD PMID: 26101662 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Author response to letter to the editor "Protocolized weaning from mechanical strategy in COPD: respiratory therapists versus physician directed-who guides best?".
Authors: Kirakli C, Ediboglu O, Naz I, Cimen P, Tatar D PMID: 26101661 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Protocolized weaning from mechanical strategy in chronic obstructive pulmonary disease: respiratory therapists versus physician directed-who guides best?
Authors: Erbabacan E, González Pérez MI, Koksal GM, Esquinas AM PMID: 26101660 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Fixation of sternal fracture using absorbable plating system, three years follow-up.
We report the first case where absorbable plate has been used to fix a traumatic fracture in a 42-year-old female. After 3 years, the patient is still free of symptoms and CT scanning reveals intact sternal bone structure. PMID: 26101659 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Malignant glomus tumor in pleural cavity.
Authors: Lin F, Yang M, Pu Q, Ma L, Liu C, Mei J, Guo C, Liu L Abstract Glomus tumors, an uncommon hypervascular tumor, arise from modified smooth muscle cells of the glomus body that plays a significant role in the regulation of skin circulation. The tumors are usually located in the extremities, typically in the subungual region of the fingers. Primary glomus tumors of the chest are extremely rare, and to our knowledge, there are no cases have been described in thoracic cavity to date. We here report a case of intrathoracic glomus tumor in a 31-year-old man who presented with a persistent chest pain. Chest comput...
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Single incision thoracoscopic lobectomy through a 2.5 cm skin incision.
Authors: Yang HC, Noh D Abstract Single incision thoracoscopic surgery (SITS) involves only one intercostal space with minimal skin incision, which means it can be the most minimally invasive technique up to date. We minimized the skin incision to a length of 2.5 cm to achieve the less chest wall trauma and the more cosmesis during SITS lobectomy for benign pulmonary disease. Four patients who had bronchiectasis [left lower lobe (LLL)], congenital lobar emphysema [left upper lobe (LUL)], aspergilloma [right upper lobe (RUL)], and hamartoma (RUL) were planned to undergo 2.5 cm SITS lobectomy. There were no conversio...
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Migratory eosinophilic alveolitis caused by radiation therapy.
We report the case of a 27-year-old female with radiation pneumonitis, occurring 4 months after radiation therapy for cancer of the left breast. Clinical and radiological relapse followed withdrawal of corticosteroids. Examination of bronchoalveolar lavage (BAL) in patchy airspace consolidations revealed increased eosinophil counts. Finally, clinical and radiological signs resolved rapidly after reintroduction of corticosteroids. Eosinophilic alveolitis may be promoted by radiation therapy. In the present case report, possible mechanisms for radiation-induced eosinophilic alveolitis are also reviewed. PMID: 26101656 [...
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Beware the 'raised right hemidiaphragm' in a female patient with previous pneumothorax surgery: liver herniation through a massive endometrosis-related diaphragmatic fenestration.
Authors: Yu PS, Sihoe AD Abstract A 44-year-old non-smoking woman presented with recurrent right spontaneous pneumothorax 9 years after a right-side surgical pleurodesis via a video-assisted thoracic surgery (VATS) approach for suspected primary pneumothorax in another center. Histological examination of tissue excised during the earlier operation confirmed catamenial pneumothorax, but no further treatment was given. During the 9 years since, she had had persistent right lower chest pain and chest X-ray (CXR) had shown a "persistently elevated right diaphragm", but these had been treated as iatrogenic neuropathic p...
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Artificial neural networks for small dataset analysis.
Authors: Pasini A Abstract Artificial neural networks (ANNs) are usually considered as tools which can help to analyze cause-effect relationships in complex systems within a big-data framework. On the other hand, health sciences undergo complexity more than any other scientific discipline, and in this field large datasets are seldom available. In this situation, I show how a particular neural network tool, which is able to handle small datasets of experimental or observational data, can help in identifying the main causal factors leading to changes in some variable which summarizes the behaviour of a complex system...
Source: Journal of Thoracic Disease - June 26, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research