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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Modulation of Alternaria infectoria cell wall chitin and glucan synthesis by cell wall synthase inhibitors.
Abstract The present work reports the effect of caspofungin, a β-1,3-glucan synthase inhibitor, and nikkomycin Z, an inhibitor of chitin synthases, on two strains of Alternaria infectoria, a melanized fungus involved in opportunistic human infections and respiratory allergies. One of the strains tested, IMF006, bore phenotypic traits that conferred advantages in resisting antifungal treatment. First, the resting cell wall chitin content was higher and, in response to caspofungin, its chitin level remained constant. In the other strain, IMF001, the chitin content increased upon caspofungin treatment to values simil...
Source: Antimicrobial Agents and Chemotherapy - March 10, 2014 Category: Microbiology Authors: Fernandes C, Anjos J, Walker LA, Silva BM, Cortes L, Mota M, Munro CA, Gow NA, Gonçalves T Tags: Antimicrob Agents Chemother Source Type: research

Short-term sustained hypoxia induces changes in the coupling of sympathetic and respiratory activities in rats.
Abstract Individuals experiencing sustained hypoxia (SH) exhibit adjustments in the respiratory and autonomic functions by neural mechanisms not yet elucidated. In the present study we evaluated the central mechanisms underpinning the SH-induced changes in the respiratory pattern and their impact on the sympathetic outflow. Using a decerebrated arterially-perfused in situ preparation, we verified that juvenile rats exposed to SH (10% O2) for 24 h presented an active expiratory pattern, with increased abdominal, hypoglossal and vagal activities during late-expiration (late-E). SH also enhanced the activity of augmen...
Source: The Journal of Physiology - March 10, 2014 Category: Physiology Authors: Moraes DJ, Bonagamba LG, Costa KM, Costa-Silva JH, Zoccal DB, Machado BH Tags: J Physiol Source Type: research

Perioperative complications in patients diagnosed with mucopolysaccharidosis and the impact of enzyme replacement therapy followed by hematopoietic stem cell transplantation at early age.
CONCLUSION: Perioperative airway management was most successful using a laryngeal mask airway or video laryngoscope. Treatment with ERT followed by HSCT and patient age did not influence the incidence of perioperative respiratory problems. PMID: 24612129 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - March 10, 2014 Category: Anesthesiology Authors: Megens JH, de Wit M, van Hasselt PM, Boelens JJ, van der Werff DB, de Graaff JC Tags: Paediatr Anaesth Source Type: research

Heat shock protein complex vaccination induces protection against Helicobacter pylori without exogenous adjuvant.
CONCLUSIONS: H. pylori HspC vaccines have the potential to overcome some of the issues preventing the development of a human vaccine against this pathogen: HspC induced protective immunity against H. pylori without addition of an adjuvant and without the induction of a severe inflammatory response. However, complete protection was not obtained so further optimisation of this technology is needed if a human vaccine is to become a reality. PMID: 24625340 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - March 10, 2014 Category: Allergy & Immunology Authors: Chionh YT, Arulmuruganar A, Venditti E, Ng GZ, Han JX, Entwisle C, Ang CS, Colaco CA, McNulty S, Sutton P Tags: Vaccine Source Type: research

[Veno-venous extracorporeal oxygenation and veno-arterial extracorporeal oxygenation. Questions, answers.]
Abstract A round table, organized by the French Society of Perfusion (Sofraperf) at the French national congress on extracorporeal circulations (Perfusion 2013), was attended by perfusionists, anaesthesiologists, intensivists and surgeons around the theme of respiratory veno-venous support and veno-arterial circulatory support with extracorporeal oxygenation in intensive care units. The debate was conducted in a participatory manner by bi-directional questions-answers session between moderators and assistance. The authors report management of this type of therapy that is not perfectly homogeneous, supported on lite...
Source: Annales Francaises d'Anesthesie et de Reanimation - March 10, 2014 Category: Anesthesiology Authors: Isetta C, Lebreton G, Janot N, Prommenschenkel M, Rilos Z, Roques F, Longrois D Tags: Ann Fr Anesth Reanim Source Type: research

Early changes in respiratory quotient and resting energy expenditure predict later weight changes in patients treated for poorly controlled type 2 diabetes.
CONCLUSION: In poorly controlled patients with T2D and two days after the introduction of a bedtime insulin analogue, REE decreased by -9% while RQ increased by +5%, pointing to a reduction of lipid oxidation. These changes were predictive of later weight gain. PMID: 24636224 [PubMed - as supplied by publisher] (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - March 10, 2014 Category: Endocrinology Authors: Gonzalez C, Fagour C, Maury E, Cherifi B, Salandini S, Pierreisnard A, Masquefa-Giraud P, Gin H, Rigalleau V Tags: Diabetes Metab Source Type: research

[Congenital nasal obstruction due to pyriform aperture stenosis. A case series.]
We describe our experience with 5 patients with this condition, treated surgically using a sub-labial approach, and followed by nasal stenting. PMID: 24635981 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - March 10, 2014 Category: Pediatrics Authors: Cuestas G, José G, Demarchi V, Razetti J, Boccio C Tags: An Pediatr (Barc) Source Type: research

Noninvasive mechanical ventilation and mechanical in‐exsufflator: A definitive solid combination? Some key methodology considerations
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 9, 2014 Category: Respiratory Medicine Authors: Antonio M. Equinas, Prakesh S. Shah Tags: Letter to the Editor Source Type: research

Tracheoplasty using the thymus against tracheo‐esophageal fistula due to necrotizing tracheobronchitis in a very low birth weight infant
We report a case of a very low birth weight infant treated successfully with tracheoplasty using the thymus against tracheo‐esophageal fistula due to necrotizing tracheobronchitis. A baby boy was born at 31 weeks gestation with a birth body weight of 1,230 g. Suddenly on Day 19, his respiration deteriorated, and a flexible bronchofiberscopy showed tracheostenosis, tracheomalacia, and tracheal diverticula. On Day 21, his abdomen became significantly distended, and a flexible bronchofiberscopy showed a tracheo‐esophageal fistula due to a rupture of the diverticula. On Day 105, during surgery, we confirmed necrosis of t...
Source: Pediatric Pulmonology - March 9, 2014 Category: Respiratory Medicine Authors: Hisaya Hasegawa, Yuzo Nagase, Miho Sakai, Nobuhide Henmi, Shio Tsuruta Tags: Case Report Source Type: research

Polymorphisms of the gene encoding Kit ligand are associated with bronchopulmonary dysplasia
Conclusions: We show that KITLG polymorphisms are associated with susceptibility to moderate‐to‐severe BPD. In addition, higher Kit ligand concentrations were observed in infants that subsequently developed BPD. These results support the possibility that KITLG gene is involved in predisposition to BPD. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 9, 2014 Category: Respiratory Medicine Authors: Johanna M. Huusko, Mari Mahlman, Minna K. Karjalainen, Tuula Kaukola, Ritva Haataja, Riitta Marttila, Gergely Toldi, Miklós Szabó, Stephen F. Kingsmore, Mika Rämet, Pascal M. Lavoie, Mikko Hallman, Tags: Original Article: Neonatal Lung Disease Source Type: research

Iloprost for children with pulmonary hypertension after surgery to correct congenital heart disease
This study supports the use of iloprost to treat children with PH following surgery to correct CHD. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 9, 2014 Category: Respiratory Medicine Authors: Zhuoming Xu, Limin Zhu, Xinrong Liu, Xiaolei Gong, William Gattrell, Jinfen Liu Tags: Original Article: Other Source Type: research

Detrimental effects of secondhand smoke exposure on infants with cystic fibrosis
ConclusionsSHS exposure in CF infants is associated with diminished growth, increased air trapping and bronchodilator responsiveness, and propensity to culture MRSA and facultative anaerobic bacteria, suggesting the need for early, aggressive parental smoking cessation interventions to prevent SHS exposure complications. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 9, 2014 Category: Respiratory Medicine Authors: Benjamin T. Kopp, Lisa Sarzynski, Sabrina Khalfoun, Don Hayes, Rohan Thompson, Lisa Nicholson, Frederick Long, Robert Castile, Judith Groner Tags: Original Article: Cystic Fibrosis Source Type: research

A pharmacokinetic/clinical approach to postulate a local action of intra‐articular xylazine administration in the horse: a preliminary study
In conclusion, a systemic action of the drug after IA administration cannot be excluded. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - March 8, 2014 Category: Veterinary Research Authors: A. Di Salvo, G. Della Rocca, C. Bazzica, A. Giontella, P. Cagnardi, S. Nannarone Tags: Scientific Paper Source Type: research

Viral aetiology and clinical outcomes in hospitalised infants presenting with respiratory distress
ConclusionRSV dominates as the viral cause in hospitalised infants with respiratory distress in Sweden during the winter season, resulting in a clinical course that is significantly more severe. The multiplex assays produced reasonably concordant results.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - March 8, 2014 Category: Pediatrics Authors: Kathy Falkenstein‐Hagander, Ann‐Sofie Månsson, Johan Redmo, Percy Nilsson, Anders Widell Tags: Regular Article Source Type: research

Highlights from this issue
Cheap is cheerful – and certainly adequate We are delighted to have a strong line-up of asthma papers this month. Our editors’ choice (see page 328) investigates the safety of long acting beta2 agonists (LABA) with and without inhaled corticosteroids. A recent audit in Thorax showed that LABA monotherapy is still depressingly common in the UK and it likely accounts for the mortality concerns that have fuelled several multimillion dollar FDA mandated studies of LABA safety. The authors used administrative health database records to compare asthma related hospitalisations (accepted as a proxy of mortality in the ...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Tags: Airwaves Source Type: research

Time for a preventative strategy for TB in the UK: further evidence for new entrant screening in primary care
In 2012, a total of 8751 cases of TB in the UK were reported at a rate of 13.9 cases per 100 000—this figure is on the background of an increase over two decades in notifications and rates with no evidence of any reduction since peaking in 2005.1 This rise has been largely attributed to TB in the foreign-born, with 73% of all cases of TB being born in high-incidence countries. By contrast, the cases of TB in the UK born have been static over the last decade. Given that these cases are largely due to reactivation disease,2 a strategy of TB control purely based on detection and treatment of active pulmonary d...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Kon, O. M. Tags: Editorial Source Type: research

Taking airway disease seriously
Sadatsafavi and colleagues address the question of the safety of long-acting β-agonists (LABA) in asthma with and without the concomitant use of inhaled corticosteroids (ICS).1 They carried out a study within the administrative healthcare databases of the province of British Columbia, Canada. The universal healthcare system provides healthcare for all residents of the province and includes coverage of prescription drugs. The results of the study are therefore based on a complete population avoiding the exaggeration of benefit and the minimisation of harm that may result in randomised controlled trials (RCTs) which oft...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Ernst, P. Tags: Editorial Source Type: research

Correction
Highlights from this issue. Thorax 2014;69:i. doi:10.1136/thoraxjnl-2014-205146 In the sentence ‘Evolution has ensured that numerous genes associated with a profibrotic state have survived through the generations’, the word ‘profibrotic’ should read ‘prothrombotic’. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Tags: Corrections Source Type: research

Year in review 2013: paediatric and adult clinical studies
This is the first of two reviews of Thorax in 2013 focusing on manuscripts dealing with the clinical aspects of paediatrics and adult respiratory medicine. Our prizes last year were a popular addition and so we have retained this in 2013. Decisions are purely those of the editors and deputy editors. Our only restriction has been to not consider manuscripts from Imperial, Leicester and Oxford, not because they were too numerous or too good (regrettably), but because we have conflicts of interest. Paediatrics Cystic fibrosis (CF) is an area with major research activity, especially with the introduction of new therapies bolst...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Bush, A., Pavord, I. Tags: Editorial Source Type: research

Once-daily fluticasone furoate (FF)/vilanterol reduces risk of severe exacerbations in asthma versus FF alone
Conclusions Once-daily FF/VI reduced the risk of severe asthma exacerbations and improved lung function compared with FF alone, with good tolerability and safety profile in adolescents and adults with asthma currently receiving ICS. ClinicalTrials.gov No NCT01086384 (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Bateman, E. D., O'Byrne, P. M., Busse, W. W., Lotvall, J., Bleecker, E. R., Andersen, L., Jacques, L., Frith, L., Lim, J., Woodcock, A. Tags: Open access, Child health, Asthma, Drugs: respiratory system Source Type: research

Is chest CT useful in newborn screened infants with cystic fibrosis at 1 year of age?
Conclusions In NBS infants with CF, CT changes were very mild at 1 year, and assessment of air trapping was the only reproducible outcome. CT is thus of questionable value in infants of this age, unless an improved scoring system for use in mild CF disease can be developed. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Thia, L. P., Calder, A., Stocks, J., Bush, A., Owens, C. M., Wallis, C., Young, C., Sullivan, Y., Wade, A., McEwan, A., Brody, A. S., on behalf of the London Cystic Fibrosis Collaboration (LCFC) Tags: Open access, Cystic fibrosis Source Type: research

Dispensation of long-acting {beta} agonists with or without inhaled corticosteroids, and risk of asthma-related hospitalisation: a population-based study
Conclusions Regular dispensation of ICS+LABA was not associated with an increased risk of asthma-related hospitalisation compared with regular dispensation of ICS alone. Adherence to ICS in patients who regularly receive ICS+LABA seems to be an important factor in the prevention of adverse asthma-related outcomes. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Sadatsafavi, M., Lynd, L. D., Marra, C. A., FitzGerald, J. M. Tags: Epidemiologic studies, Editor's choice, Asthma, Drugs: respiratory system Respiratory research Source Type: research

Telehealth for chronic disease management
In this cluster randomised controlled trial, Cartwright et al1 evaluated the outcomes of telehealth on patient reported outcomes in a primary care population with chronic disease. Telehealth is the use of remote data exchange between patients at home and health professionals to assist management of long-term conditions. It is heralded as a solution to our growing elderly population with its significant chronic disease burden. The Department of Health has commissioned Whole Systems Demonstrator (WSD) to analyse the efficacy and cost-effectiveness of telehealth. The WSD study consists of a series of nested analyses in a chro...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Saleh, A. Tags: Miscellanea Source Type: research

Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation
Conclusions We defined an immunodominant P pratense epitope, p26, with broad binding across multiple HLA class II alleles. Intranasal treatment of mice with p26 results in T-cell regulation to whole allergen, involving the Cbl-b and Itch regulatory pathway. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Till, S. J., Raynsford, E. J., Reynolds, C. J., Quigley, K. J., Grzybowska-Kowalczyk, A., Saggar, L. R., Goldstone, A., Maillere, B., Kwok, W. W., Altmann, D. M., Durham, S. R., Boyton, R. J. Tags: Molecular genetics, Ear, nose and throat/otolaryngology Respiratory research Source Type: research

Is ERCC1 a reliable prognostic protein biomarker in non-small-cell lung cancer?
After resection for non-small-cell lung cancer (NSCLC) cisplatin-based postoperative chemotherapy may be administered. How do we predict which patients will benefit from cisplatin chemotherapy? This group previously published that the excision repair cross-complementation group 1 (ERCC1) protein acts as a prognostic biomarker, predicting the benefit of cisplatin-based chemotherapy after NSCLC resection. ERCC1 plays a crucial role in repairing DNA structures, damaged by cisplatin-based chemotherapy. Using immunohistochemical analysis, patients with NSCLC and no detectable ERCC1 had longer disease-free survival after cisplat...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Durrington, H. J. Tags: Miscellanea Source Type: research

Moderate concentrations of supplemental oxygen worsen hypercapnia in obesity hypoventilation syndrome: a randomised crossover study
Conclusion Commonly used oxygen concentrations caused hypoventilation, PavCO2 rises and acidaemia among people with stable OHS. This highlights the potential dangers of this common intervention in this group. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Hollier, C. A., Harmer, A. R., Maxwell, L. J., Menadue, C., Willson, G. N., Unger, G., Flunt, D., Black, D. A., Piper, A. J. Tags: Health education, Obesity (public health) Respiratory physiology Source Type: research

Nodal upstaging after thoracoscopic versus open lobectomy
In this nationwide database study from Denmark, nodal upstaging and survival after thoracoscopic and open lobectomy for clinical stage I non-small cell lung cancer (NSCLC) was investigated. Clinical data for all patients diagnosed with lung cancer in Denmark are obligatorily reported to the national Danish Lung Cancer Registry (DLCR). Cross-linkage with the DLCR and other national registers is used to validate completeness of data and survival status is obtained from the Centralised Civil Registry. Surgery for lung cancer in Denmark is only performed by thoracic surgeons at four university hospitals. The DLCR was used to i...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Sartipy, U. Tags: Miscellanea Source Type: research

The effectiveness of primary care based risk stratification for targeted latent tuberculosis infection screening in recent immigrants to the UK: a retrospective cohort study
Conclusions LTBI screening at primary care registration offers an effective strategy for potentially identifying immigrants at high risk of developing TB. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Panchal, R. K., Browne, I., Monk, P., Woltmann, G., Haldar, P. Tags: Epidemiologic studies, General practice / family medicine, Drugs: infectious diseases, HIV/AIDS, Screening (epidemiology), Screening (public health) Tuberculosis Source Type: research

Cigarette smoke impairs cytokine responses and BCG containment in alveolar macrophages
Conclusions Cigarette smoke attenuates effector cytokine responses and impairs mycobacterial containment within infected human macrophages derived from the peripheral blood and alveolar compartments, thus supporting the hypothesis that cigarette smoke subverts mycobacteria-related immunity. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: van Zyl-Smit, R. N., Binder, A., Meldau, R., Semple, P. L., Evans, A., Smith, P., Bateman, E. D., Dheda, K. Tags: Screening (oncology), Health education, Smoking, Health effects of tobacco use, Tobacco use Tuberculosis Source Type: research

Risk factors for sleep-disordered breathing in pregnancy
Conclusions Third trimester OSA is common. Risk factors for third trimester OSA among women without baseline SDB include higher baseline BMI and maternal age. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Pien, G. W., Pack, A. I., Jackson, N., Maislin, G., Macones, G. A., Schwab, R. J. Tags: Epidemiologic studies, Sleep disorders (neurology), Sleep disorders, Airway biology, Sleep disorders (respiratory medicine) Sleep disordered breathing Source Type: research

Review of the British Thoracic Society Winter Meeting 2013, 4-6 December, London, UK
This article reviews the British Thoracic Society Winter Meeting 2013, the annual scientific meeting attended by over 2000 delegates and representing the depth and breadth of UK respiratory medicine. This year’s meeting from 4 to 6 December in London featured cutting-edge research alongside keynote symposia from international experts in respiratory science, epidemiology and clinical trials. This article reviews the key symposia and selected abstract sessions from the 2013 meeting. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Chalmers, J. D., Greening, N. J., Jose, R. J., Janes, S. M., on behalf of the BTS science and research committee Tags: Review Source Type: research

Prenatal origins of bronchiolitis: protective effect of optimised asthma management during pregnancy
Conclusions Optimised management of asthma during pregnancy may reduce recurrent episodes of bronchiolitis in infancy, which could potentially modulate the risk to develop or the severity of emerging childhood asthma. (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Mattes, J., Murphy, V. E., Powell, H., Gibson, P. G. Tags: Clinical trials (epidemiology), Epidemiologic studies, Open access, Bronchiolitis, TB and other respiratory infections, Child health, Asthma, Bronchitis Research letter Source Type: research

Authors' response to Walker et al.
The research letter by Walker et al1 questions the generalisability of the results of the 4-year UPLIFT trial comparing tiotropium versus placebo based on potential eligibility for UPLIFT at time of discharge of a COPD patient population in New Zealand hospitalised for an exacerbation. The authors state that 38% of their study population would have been excluded from UPLIFT. The authors' assertion regarding the limited generalisability of UPLIFT's findings to clinical practice is not valid for several reasons. First, patients hospitalised for COPD exacerbations are not representative of the general COPD population. An epid...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Tashkin, D. P., Metzdorf, N., Hallmann, C., Leimer, I., Lee, T., Decramer, M. Tags: PostScript Source Type: research

Letter in response to Tashkin et al: limited generalisability of uplift findings to clinical practice
We appreciate the comments made by Tashkin et al1 regarding the limited generalisability of the Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT) findings.2 In response, the sample we studied was not designed to be representative of the general chronic obstructive pulmonary disease (COPD) population, but rather the subgroup of patients with severe COPD who are likely to be at greatest risk of serious cardiovascular events. Second, the derived data presented from the Canadian database analysis do not correspond to the UPLIFT inclusion criteria. The UPLIFT study excluded patients with cardiac arr...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Walker, S., Fingleton, J., Weatherall, M., Beasley, R. Tags: PostScript Source Type: research

SKUP3 trial: comment
The paper on uvulopalatopharyngoplasty (the SKUP3 trial, September 2013 issue of Thorax) is a significant contribution to the literature on the surgical management of obstructive sleep apnea (OSA).1 The authors are to be congratulated on pushing through such a difficult trial with good control subjects. However, there is one concern that we have, which may alter the clinical conclusions that should be drawn. Patients for this trial were highly selected. In particular, none had had a previous tonsillectomy, and Friedman stage III (ie, only small tonsils) were specifically excluded. The Friedman stage I and II patients enter...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Stradling, J., Kohler, M. Tags: PostScript Source Type: research

Authors' response to letter to the editor concerning our SKUP3 trial
We thank Stradling and Kohler1 for their comments on our publication, SKUP3 RCT. The authors of this correspondence report their worries concerning (a) which part of the uvulopalatopharyngoplasty (UPPP) contributed most to the improvements in nocturnal respiration, tonsillectomy or uvulopalatoplasty (UPP), and (b) if that UPPP adversely influences the future use of continuous positive airway pressure (CPAP). The first worry (a) we agree concerning the difficulties when evaluating a two-stage treatment. However, the aim of SKUP3 was to evaluate the effect of UPPP, which includes tonsillectomy per definition and has been a w...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Browaldh, N., Friberg, D. Tags: PostScript Source Type: research

British Thoracic Society guideline on pulmonary rehabilitation in adults: does objectivity have a sliding scale?
We congratulate the Guideline Development Group (GDG) on the publication of their new pulmonary rehabilitation guideline.1 However, we are concerned by the contrasting recommendations for limb resistance training (LRT), which is recommended, and for inspiratory muscle training (IMT), which is not. Both interventions have identical levels of evidence (1+) and similar evidence statements. The evidence statement in relation to LRT is as follows:In patients with COPD, resistance training in combination with aerobic training does not lead to additional benefits to health-related quality of life, dyspnoea or exercise tolerance c...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: McConnell, A. K., Gosselink, R. Tags: Open access PostScript Source Type: research

The British Thoracic Society guideline on pulmonary rehabilitation in adults: your opinion is noted
We thank Professors McConnell and Gosselink for their interest in the British Thoracic Society (BTS) pulmonary rehabilitation guideline.1 2 We welcome the opportunity to highlight the robust, unbiased approach that the guideline development group (GDG) has followed in making their recommendations which have been accredited by National Institute of Health and Care Excellence. This process, according to the BTS production manual, is described in the guideline methodology.2 It included initial training, each article being considered by at least two GDG members, independent peer review at multiple stages and consultation perio...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Bolton, C. E., Blakey, J. D., Morgan, M. D., on behalf of the BTS Pulmonary Rehabilitation Guideline Development Group for the Standards of Care Committee for the BTS Tags: PostScript Source Type: research

Narcolepsy risk after A/H1N1 2009 influenza vaccination
In this study 75 children between 4–19 years of age were diagnosed with narcolepsy during the follow-up period; 11 had received the vaccine. The OR was 14.4 (95% CI 4.3 to 48.5) for vaccination after adjusting for the fact that children receiving the vaccine were more likely to be in high-risk groups. The relative incidence estimate for onset of narcolepsy after vaccination using self-controlled case series analysis was 9.9 (95% CI 2.1 to 47.9). The estimated attributable risk was between... (Source: Thorax)
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Drysdale, S. B. Tags: Miscellanea Source Type: research

Predicted relative prevalence estimates for obstructive sleep apnoea and the associated healthcare provision across the UK
We surveyed the UK distribution of five factors commonly associated with obstructive sleep apnoea (OSA) to produce an overall risk map that could be used to predict relative prevalence estimates. The weighting and mapping of selected risk factors associated with OSA highlighted significant regional variation in predicted prevalence estimates. These data provide the first attempt to systematically map the UK for OSA and identify areas where the condition is likely to be more prevalent. The data show a significant mismatch between areas identified as having a high predicted prevalence estimate and the distribution of existin...
Source: Thorax - March 8, 2014 Category: Respiratory Medicine Authors: Steier, J., Martin, A., Harris, J., Jarrold, I., Pugh, D., Williams, A. Tags: Chest clinic Source Type: research