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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Odors from sewage sludge and livestock: associations with self-reported health.
CONCLUSIONS: Reported odors from TSS and livestock were associated with some acute symptoms. Health departments should monitor land applications of human and animal wastes and conduct surveillance of health problems reported by neighbors. PMID: 25364052 [PubMed - in process] (Source: Public Health Reports)
Source: Public Health Reports - November 16, 2014 Category: Global & Universal Tags: Public Health Rep Source Type: research

Drug overdose surveillance using hospital discharge data.
CONCLUSION: The ISW7 drug overdose definition using any drug poisoning diagnosis/E-code (Definition 3) is potentially the highest sensitivity definition for counting drug overdose hospitalizations, including by intent and drug type(s) involved. As the states enact policies and plan for adequate treatment resources, standardized drug overdose definitions are critical for accurate reporting, trend analysis, policy evaluation, and state-to-state comparison. PMID: 25177055 [PubMed - indexed for MEDLINE] (Source: Public Health Reports)
Source: Public Health Reports - November 16, 2014 Category: Global & Universal Tags: Public Health Rep Source Type: research

Nitazoxanide: A first-in-class broad-spectrum antiviral agent
Publication date: October 2014 Source:Antiviral Research, Volume 110 Author(s): Jean-François Rossignol Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the treatment of influenza. A Phase 2b/3 clinical trial recently published in The Lancet Infectious Diseases found that oral administration of nitazoxanide 600mg twice daily for five days reduced the duration of clinical symptoms and reduced viral shedding compared to placebo in persons with laboratory-confirmed influenza. The same study also...
Source: Antiviral Therapy - November 16, 2014 Category: Virology Source Type: research

Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features
Publication date: September 2014 Source:Antiviral Research, Volume 109 Author(s): Jian Lei , Jeroen R. Mesters , Christian Drosten , Stefan Anemüller , Qingjun Ma , Rolf Hilgenfeld The Middle-East Respiratory Syndrome coronavirus (MERS-CoV) causes severe acute pneumonia and renal failure. The MERS-CoV papain-like protease (PLpro) is a potential target for the development of antiviral drugs. To facilitate these efforts, we determined the three-dimensional structure of the enzyme by X-ray crystallography. The molecule consists of a ubiquitin-like domain and a catalytic core domain. The catalytic domain displays an extende...
Source: Antiviral Therapy - November 16, 2014 Category: Virology Source Type: research

Clinical management and infection control of SARS: Lessons learned
Publication date: November 2013 Source:Antiviral Research, Volume 100, Issue 2 Author(s): Vincent C.C. Cheng , Jasper F.W. Chan , Kelvin K.W. To , K.Y. Yuen The outbreak of severe acute respiratory syndrome (SARS) in 2003 was the first emergence of an important human pathogen in the 21st century. Responding to the epidemic provided clinicians with extensive experience in diagnosing and treating a novel respiratory viral disease. In this article, we review the experience of the SARS epidemic, focusing on measures taken to identify and isolate patients, prevent the transmission of infection to healthcare workers and develo...
Source: Antiviral Therapy - November 16, 2014 Category: Virology Source Type: research

A treatment for and vaccine against the deadly Hendra and Nipah viruses
Publication date: October 2013 Source:Antiviral Research, Volume 100, Issue 1 Author(s): Christopher C. Broder , Kai Xu , Dimitar B. Nikolov , Zhongyu Zhu , Dimiter S. Dimitrov , Deborah Middleton , Jackie Pallister , Thomas W. Geisbert , Katharine N. Bossart , Lin-Fa Wang Hendra virus and Nipah virus are bat-borne paramyxoviruses that are the prototypic members of the genus Henipavirus. The henipaviruses emerged in the 1990s, spilling over from their natural bat hosts and causing serious disease outbreaks in humans and livestock. Hendra virus emerged in Australia and since 1994 there have been 7 human infections with 4 ...
Source: Antiviral Therapy - November 16, 2014 Category: Virology Source Type: research

Comparison of the protection of ferrets against pandemic 2009 influenza A virus (H1N1) by 244 DI influenza virus and oseltamivir
Publication date: December 2012 Source:Antiviral Research, Volume 96, Issue 3 Author(s): Nigel J. Dimmock , Brian K. Dove , Bo Meng , Paul D. Scott , Irene Taylor , Linda Cheung , Bassam Hallis , Anthony C. Marriott , Miles W. Carroll , Andrew J. Easton The main antivirals employed to combat seasonal and pandemic influenza are oseltamivir and zanamivir which act by inhibiting the virus-encoded neuraminidase. These have to be deployed close to the time of infection and antiviral resistance to the more widely used oseltamivir has arisen relatively rapidly. Defective interfering (DI) influenza virus is a natural antiviral t...
Source: Antiviral Therapy - November 16, 2014 Category: Virology Source Type: research

Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide conjugate
Publication date: January 2012 Source:Antiviral Research, Volume 93, Issue 1 Author(s): Anna Lundin , Tomas Bergström , Carla R. Andrighetti-Fröhner , Loubna Bendrioua , Vito Ferro , Edward Trybala A number of different viruses including respiratory syncytial virus (RSV) initiate infection of cells by binding to cell surface glycosaminoglycans and sulfated oligo- and polysaccharide mimetics of these receptors exhibit potent antiviral activity in cultured cells. We investigated whether the introduction of different lipophilic groups to the reducing end of sulfated oligosaccharides would modulate their anti-RSV activity....
Source: Antiviral Therapy - November 16, 2014 Category: Virology Source Type: research

Examining the latent class structure of CO2 hypersensitivity using time course trajectories of panic response systems
Conclusions Two classes potentially representing different risk pathways were observed. Implications of results will be discussed in the context of panic risk research. Graphical abstract (Source: Journal of Behavior Therapy and Experimental Psychiatry)
Source: Journal of Behavior Therapy and Experimental Psychiatry - November 16, 2014 Category: Psychiatry Source Type: research

Long-term survival with a stentless free-hand Batista pericardial aortic valve prosthesis: a case report
Conclusion Replacement of the aortic valve with a free-hand Batista pericardial valve is a feasible option in a suitable and carefully-selected patient. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - November 16, 2014 Category: Surgery Source Type: research

ISAV infection promotes apoptosis of SHK-1 cells through a ROS/p38 MAPK/Bad signaling pathway
Publication date: Available online 15 November 2014 Source:Molecular Immunology Author(s): Víctor H. Olavarría , Pablo Recabarren , Fernanda Fredericksen , Melina Villalba , Alejandro Yáñez The impact that the infectious salmon anemia virus (ISAV) has on the immune response of Salmo salar, from the perspective of activating/inactivating cellular processes, is currently unknown. Therefore, the present study evaluated this interaction and found that SHK-1 cells infected with ISAV resulted in respiratory burst activation and the induction of a strong pro-apoptotic imbalance through an increased expression of the Bad pro...
Source: Molecular Immunology - November 16, 2014 Category: Allergy & Immunology Source Type: research

Data review of an ongoing telehealth programme in a tertiary paediatric hospital
The Royal Children's Hospital (RCH) in Melbourne has been providing teleconsultations since 2011 using web-based videoconferencing. We reviewed telehealth activity over the first 30 months of the programme. The average consultation rate was 14 per month in 2012, 39 in 2013 and 49 per month in the first half of 2014. One-third of all activity (265 out of 852 consultations) was provided by only two departments: neurology and respiratory medicine. By June 2014, 92% of departments (n = 34) had provided one or more video-consultations. Most telehealth activity was provided by just a few clinicians. A review of actual and billed...
Source: Journal of Telemedicine and Telecare - November 16, 2014 Category: Information Technology Authors: Jury, S. C., Kornberg, A. J. Tags: RESEARCH/Original articles Source Type: research

Sojourn in excessively high oxygen saturation ranges in individual, very low‐birthweight neonates
ConclusionMeasures to improve compliance with targeted SpO2 ranges should be applied universally although further improvement may be achieved by specifically targeting babies receiving supplemental oxygen via nasal cannula. (Source: Acta Paediatrica)
Source: Acta Paediatrica - November 16, 2014 Category: Pediatrics Authors: Jenda Arawiran, JeanneMarie Curry, Lorna Welde, Gad Alpan Tags: Regular Article Source Type: research

Magnetic resonance imaging of vein wall thickness in patients with Behçet's syndrome.
CONCLUSIONS: MR imaging can detect increased vein wall thickness in BS subjects compared to healthy controls. Variable response to the metronome-guided breathing requires further development. PMID: 25268665 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - November 15, 2014 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The Influence of Particulate Matter on Respiratory Morbidity and Mortality in Children and Infants.
Authors: Jakubiak-Lasocka J, Lasocki J, Badyda AJ Abstract Air pollution is the most important environmental health risk leading to premature mortality, respiratory and other health problems. The aim of this study was to quantify its impact on infants and children in Warsaw (Poland), following the principles of Health Impact Assessment method. Particulate matter (PM2.5 and PM10) was considered as the indicator of air pollution. Exposure-response functions between air pollution and health impacts were employed based on the literature. According to the calculations, around 5,201 asthma symptoms and 234 hospital respi...
Source: Advances in Experimental Medicine and Biology - November 15, 2014 Category: Research Tags: Adv Exp Med Biol Source Type: research

Respiratory Infections in Travelers Returning from the Tropics.
Authors: Korzeniewski K, Nitsch-Osuch A, Lass A, Guzek A Abstract Respiratory tract infections (RTIs), beside diarrheas, skin lesions, and fevers of unknown origin, are one of the most common health problems acquired by travelers going to tropical and subtropical countries. Visitors to African, Asian, or South American destinations, typically characterized by harsh environmental conditions and poor sanitation standards, are at risk of exposure to a large number of pathogens causing infectious diseases. The infections are transmitted from contaminated food and water, through the air, direct contact, or by insects. T...
Source: Advances in Experimental Medicine and Biology - November 15, 2014 Category: Research Tags: Adv Exp Med Biol Source Type: research

Editors’ choice
(Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Exciting times ahead: a partnership with Nature Group
Paul Stephenson, Aziz Sheikh (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Vitamin D and the HLA locus help to explain the relationship between autoimmune and allergic diseases
Scott Weiss (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Comorbidity in asthma is important and requires a generalist approach
Stewart Mercer (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

A golden goal in 2010, and another GOLD in 2014 in primary care, or vice versa
Joan Soriano, Miguel Rodríguez (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

National cohort data from Sweden to the National COPD audit in England and Wales: grand designs for quality improvement
Rupert Jones, Michael Roberts (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

On Goldilocks, care coordination, and palliative care: making it ‘just right’
Thomas LeBlanc, David Currow, Amy Abernethy (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Predicting the outcome of early childhood wheeze: mission impossible
Paul Brand (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Can nurses successfully diagnose and manage patients with COPD?
Paul Enright, Elizabeth Halcomb, Luis Torre-Bouscoulet (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Transgenerational occurrence of allergic disease and autoimmunity: general practice-based epidemiological research
Tanja Maas, Chris Nieuwhof, Valeria Passos, Caroline Robertson, Annelies Boonen, Robert Landewé, J Voncken, J Knottnerus, Jan Damoiseaux (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Chronic disease co-morbidity of asthma and unscheduled asthma care among adults: results of the national telephone health interview survey German Health Update (GEDA) 2009 and 2010
Henriette Steppuhn, Ute Langen, Thomas Keil, Christa Scheidt-Nave (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Are GOLD ABCD groups better associated with health status and costs than GOLD 1234 grades? A cross-sectional study
Melinde Boland, Apostolos Tsiachristas, Annemarije Kruis, Niels Chavannes, Maureen Rutten-van Mölken (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Management, morbidity and mortality of COPD during an 11-year period: an observational retrospective epidemiological register study in Sweden (PATHOS)
Björn Ställberg, Christer Janson, Gunnar Johansson, Kjell Larsson, Georgios Stratelis, Gunilla Telg, Karin Lisspers (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Coordination of end-of-life care for patients with lung cancer and those with advanced COPD: are there transferable lessons? A longitudinal qualitative study
Eleni Epiphaniou, Cathy Shipman, Richard Harding, Bruce Mason, Scott Murray, Irene Higginson, Barbara Daveson (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score
Lonneke van der Mark, Karina van Wonderen, Jacob Mohrs, Wim van Aalderen, Gerben ter Riet, Patrick Bindels (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Wheezing phenotypes in young children: an historical cohort study
Alfredo Cano-Garcinuño, Isabel Mora-Gandarillas, the SLAM Study Group (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Accuracy of diagnosis and classification of COPD in primary and specialist nurse-led respiratory care in Rotherham, UK: a cross-sectional study
Mark Strong, Angela Green, Elizabeth Goyder, Gail Miles, Andrew Lee, Gurnam Basran, Jo Cooke (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Inappropriate prescribing of combination inhalers in Northern Ireland: retrospective cross-sectional cohort study of prescribing practice in primary care
Joan Sweeney, Chris Patterson, Stephen O’Neill, Ciaran O’Neill, Gillian Plant, Veranne Lynch, Teresa McAllister, Liam Heaney (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Performance of a brief asthma control screening tool in community pharmacy: a cross-sectional and prospective longitudinal analysis
Kate LeMay, Carol Armour, Helen Reddel (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Impact of switching to new spirometric reference equations on severity staging of airflow obstruction in COPD: a crosssectional observational study in primary care
Romina Sluga, Ivo Smeele, Annelies Lucas, Bart Thoonen, Joke Grootens-Stekelenburg, Yvonne Heijdra, Tjard Schermer (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Validation of the COPD Diagnostic Questionnaire in an Australian general practice cohort: a cross-sectional study
Anthony Stanley, Iqbal Hasan, Alan Crockett, Onno van Schayck, Nicholas Zwar (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

The Global Alliance against Respiratory Diseases (GARD) Country Report
Arzu Yorgancioglu, Alvaro Cruz, Jean Bousquet, Nikolai Khaltaev, Shanti Mendis, Alexander Chuchalin, Eric Bateman, Paulo Camargos, Niels Chavannes, Chunxue Bai, Diana Deleanu, Vitezslav Kolek, Piotr Kuna, Giovanna Laurendi, Mohammed Masjedi, Sonia Mele, Florin Mihaltan, José Pinto, Boleslaw Samolinski, Giselda Scalera, Talant Sooronbaev, Mohamed Tageldin, Le Tuyetlan, Osman Yusuf, Cezmi Akdis, Abay Baigenzhin, Carlos Cagnani, Monica Fletcher, Bilun Gemicioglu, Yousser Muhammed, Hironori Sagra, Teresa To, Antje-H Wagner (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Indolent pneumonia in a pregnant recent immigrant from Ethiopia: think TB
Hashem Bishara, Moshe Lidji, Olga Vinitsky, Daniel Weiler-Ravell (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Challenges of tuberculosis management in high and low prevalence countries in a mobile world
Chris Griffiths, Monica Barne, Puneet Saxena, John Yaphe (Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Journalwatch@pcrj
(Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

News
(Source: Primary Care Respiratory Journal)
Source: Primary Care Respiratory Journal - November 15, 2014 Category: Primary Care Source Type: research

Effective management of ARDS
This article provides an overview of the disorder, including current treatment considerations. (Source: The Nurse Practitioner)
Source: The Nurse Practitioner - November 15, 2014 Category: Nursing Tags: Feature: PULMONARY Source Type: research

Did introduction of pneumococcal vaccines in the Netherlands decrease the need for respiratory antibiotics in children? Analysis of 2002 to 2013 data.
PMID: 25394256 [PubMed - in process] (Source: Euro Surveill)
Source: Euro Surveill - November 15, 2014 Category: Infectious Diseases Authors: Gefenaite G, Bijlsma M, Bos H, Hak E Tags: Euro Surveill Source Type: research

Regulation of Endothelial Cell Inflammation and Lung Polymorphonuclear Lymphocyte Infiltration by Transglutaminase 2
ABSTRACT: We addressed the role of transglutaminase 2 (TG2), a calcium-dependent enzyme that catalyzes cross-linking of proteins, in the mechanism of endothelial cell (EC) inflammation and lung polymorphonuclear lymphocyte (PMN) infiltration. Exposure of EC to thrombin, a procoagulant and proinflammatory mediator, resulted in activation of the transcription factor nuclear factor κB (NF-κB) and its target genes, vascular cell adhesion molecule 1, monocyte chemotactic protein 1, and interleukin 6. RNAi knockdown of TG2 inhibited these responses. Analysis of NF-κB activation pathway showed that TG2 knockdown was associated...
Source: Shock - November 15, 2014 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Macrophage-Derived Chemokine (CCL22) Is a Novel Mediator of Lung Inflammation Following Hemorrhage and Resuscitation
ABSTRACT: Resuscitation of patients after hemorrhage often results in pulmonary inflammation and places them at risk for the development of acute respiratory distress syndrome. Our previous data indicate that macrophage-derived chemokine (MDC/CCL22) is elevated after resuscitation, but its direct role in this inflammatory response is unknown. Macrophage-derived chemokine signaling through the C-C chemokine receptor type 4 (CCR4) is implicated in other pulmonary proinflammatory conditions, leading us to hypothesize that MDC may also play a role in the pathogenesis of lung inflammation following hemorrhage and resuscitation....
Source: Shock - November 15, 2014 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

P-glycoprotein in the Developing Human Brain: A Review of the Effects of Ontogeny on the Safety of Opioids in Neonates
Abstract: The human blood brain barrier is responsible for maintaining brain homeostasis and protecting against potentially toxic substances. The ATP-binding cassette drug efflux protein, P-glycoprotein (P-gp) is a key player in actively extruding a wide range of xenobiotics such as opioids from the brain. Because the blood brain barrier is structurally and functionally immature in neonates, opioids may have a greater penetration to the central nervous system. This may influence the efficacy and safety of opioids in the newborn. Understanding the extent of P-gp's expression in the brain in the embryo, fetus, and newborn wi...
Source: Therapeutic Drug Monitoring - November 15, 2014 Category: Drugs & Pharmacology Tags: Review Article Source Type: research

Comorbidities in Infants with Obstructive Sleep Apnea
Conclusion:Comorbidities in infants with OSA differ from those of older children. Based upon the comorbidities identified in our study population, it appears that appropriate management of infants with OSA requires a multidisciplinary approach involving genetics, gastroenterology, pulmonology, otolaryngology, neurology, and general pediatrics.Citation:Qubty WF, Mrelashvili A, Kotagal S, Lloyd RM. Comorbidities in infants with obstructive sleep apnea. J Clin Sleep Med 2014;10(11):1213-1216. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - November 15, 2014 Category: Sleep Medicine Source Type: research

The Impact of Recent Changes to the Respiratory Scoring Rules in Pediatrics
Conclusion:The AASM 2007 rules lead to a lower OAHI and lesser OSA severity when compared to the previous standard. Inclusion of RERAs in the AASM 2007 OAHI leads to a comparable OAHI to the previous rules. Given that morbidity has been demonstrated even in mild OSA, these results support the inclusion of events with a reduction in airflow of less than 50% as included in the updated AASM rules in 2012.Citation:Nixon GM, Hyde M, Biggs SN, Walter LM, Horne RS, Davey MJ. The impact of recent changes to the respiratory scoring rules in pediatrics. J Clin Sleep Med 2014;10(11):1217-1221. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - November 15, 2014 Category: Sleep Medicine Source Type: research

Scoring Respiratory Events in Sleep Medicine: Who Is the Driver—Biology or Medical Insurance?
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - November 15, 2014 Category: Sleep Medicine Source Type: research