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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Electrostatics of pharmaceutical aerosols for pulmonary delivery.
Abstract This paper provides a review on key research findings in the rapidly developing area of pharmaceutical aerosol electrostatics. Solids and liquids can become charged without electric fields, the former by contact or friction and the latter by flowing or spraying. Therefore, charged particles and droplets carrying net charges are produced from pharmaceutical inhalers (e.g. dry powder inhalers, metered dose inhalers, and nebulisers) due to the mechanical processes involved in aerosolisation. The charging depends on many physicochemical factors, such as formulation composition, solid state properties, inhaler ...
Source: Current Pharmaceutical Design - August 20, 2015 Category: Drugs & Pharmacology Authors: Kwok PC Tags: Curr Pharm Des Source Type: research

Chinese Medicine in Inhalation Therapy: A Review of Clinical Application and Formulation Development.
Abstract Chinese medicine (CM) in inhalation therapy has a long history of applications since ancient China in the forms of smoke, steam vapor, medicated pillows and aromatic sachets. Over the years, thousands of clinical treatments involving the inhalation of CMs have been reported for the treatment of respiratory disease. Shuanghuanglian, Yuxingcao and Qingkailing are primarily applied in pneumonia and bronchitis. At present, metered dose inhalation (MDI), aromatic inhalation and nebulized inhalation are used extensively in practice. In particular, nebulized CM for the treatment of respiratory diseases has been a...
Source: Current Pharmaceutical Design - August 20, 2015 Category: Drugs & Pharmacology Authors: Miao X, Zhou J, Li J, Liao Y, Zheng Y Tags: Curr Pharm Des Source Type: research

Ketamine-Propofol Versus Propofol Alone for Procedural Sedation in the Emergency Department: A Systematic Review and Meta-analysis.
CONCLUSIONS: The premise of combining ketamine with propofol is based on the many synergies that theoretically exist between these two agents. In this study, K-P had a lower frequency of adverse respiratory events in patients undergoing PSA in the ED compared to propofol alone. PMID: 26292077 [PubMed - as supplied by publisher] (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - August 20, 2015 Category: Emergency Medicine Authors: Yan JW, McLeod SL, Iansavitchene A Tags: Acad Emerg Med Source Type: research

Neutrophil contributions to the induction and regulation of the acute inflammatory response in teleost fish.
We report that, on receiving the necessary signals, teleost (Carassius auratus) neutrophils leave the hematopoietic kidney, enter into the circulation, and dominate the initial influx of cells into a site of inflammation. Unlike mammals, teleost neutrophils represent <5% of circulating leukocytes during periods of homeostasis. However, this increases to nearly 50% immediately after intraperitoneal challenge with zymosan, identifying a period of neutrophilia that precedes the peak influx of neutrophils into the challenge site at 18 h after injection). We demonstrate that neutrophils at the site of inflammation alter thei...
Source: Journal of Leukocyte Biology - August 20, 2015 Category: Hematology Authors: Havixbeck JJ, Rieger AM, Wong ME, Hodgkinson JW, Barreda DR Tags: J Leukoc Biol Source Type: research

Pulmonary Venous Varix.
PMID: 26292146 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 20, 2015 Category: Respiratory Medicine Authors: Palkar A, Shah R, Greben C, Talwar A Tags: Am J Respir Crit Care Med Source Type: research

Comparison of Treatment Response in Idiopathic and Connective Tissue Disease-Associated Pulmonary Arterial Hypertension.
Conclusions Treatment for PAH was less effective in CTD-PAH compared to IPAH in terms of increasing 6MWD and preventing clinical worsening. The heterogeneity of treatment response supports the need for identifying therapies that are more effective for CTD-PAH. PMID: 26291092 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 20, 2015 Category: Respiratory Medicine Authors: Rhee RL, Gabler NB, Sangani S, Praestgaard A, Merkel PA, Kawut SM Tags: Am J Respir Crit Care Med Source Type: research

Reversal of Opioid-Induced Ventilatory Depression Using Low-Dose Naloxone (0.04 mg): a Case Series.
CONCLUSION: ED patients with moderate to severe opioid-induced ventilatory depression can be reversed using 0.04 mg IV naloxone with appropriate dose titration. PMID: 26289651 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - August 20, 2015 Category: Toxicology Authors: Kim HK, Nelson LS Tags: J Med Toxicol Source Type: research

Muricauda pacifica sp. nov., isolated from seawater of the South Pacific Gyre.
Abstract A Gram-stain-negative, strictly aerobic, non-flagellated, non-gliding, oxidase- and catalase-positive, rod-shaped and orange-pigmented bacterium with appendages, designated strain SW027T, was isolated from a surface seawater sample collected from the South Pacific Gyre (26°29' S 137°56' W) during the Integrated Ocean Drilling Program (IODP) Expedition 329. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain SW027T shared the highest sequence similarity with members of the genus Muricauda (94.3-92.7%), exhibiting 94.3% sequence similarity to Muricauda flavescens SW-62T. Optimal gr...
Source: International Journal of Systematic and Evolutionary Microbiology - August 20, 2015 Category: Microbiology Authors: Zhang Z, Gao X, Qiao Y, Wang Y, Zhang XH Tags: Int J Syst Evol Microbiol Source Type: research

[Deep vein thrombosis due to protein C deficiency in a neonate].
CONCLUSION: In cases of neonatal thrombosis, seeking a deficiency anticoagulant factor, in particular of protein C, is essential in the newborn and in both parents. Therapeutic management is not codified. An individualized approach is appropriate in this very rare clinical situation. PMID: 26299911 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - August 20, 2015 Category: Pediatrics Authors: Rahal H, Radouani MA, Knouni H, Barkat A Tags: Arch Pediatr Source Type: research

Mixed Copd-asthma Phenotype: ACOS or CAOS? A Reflection on Recent Guidelines and Recommendations.
PMID: 26299441 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - August 20, 2015 Category: Respiratory Medicine Authors: Fernández-Villar A, López-Campos JL Tags: Arch Bronconeumol Source Type: research

Detecting Respiratory Viral RNA using Expanded Genetic Alphabets and Self-Avoiding DNA.
Abstract Nucleic acid (NA)-targeted tests detect and quantify viral DNA and RNA (collectively xNA) to support epidemiological surveillance and, in individual patients, guide therapy. They commonly use PCR and reverse-transcription PCR. Although these all have rapid turnaround, they are expensive to run. Multiplexing would allow their cost to be spread over multiple targets, but often only with lower sensitivity and accuracy, noise, false positives, and false negatives; these arise by interactions between the multiple nucleic acid primers and probes in a multiplexed kit. We offer here a multiplexed assay for a panel...
Source: Analytical Biochemistry - August 20, 2015 Category: Biochemistry Authors: Glushakova LG, Sharma N, Hoshika S, Bradley AC, Bradley KM, Yang Z, Benner SA Tags: Anal Biochem Source Type: research

Influence of GTP on System Specific Chaperone - Twin Arginine Signal Peptide Interaction.
In this study, we have utilized the in vitro protein-protein interaction technique of an affinity pull down assay, as well as protein thermal stability measurement via differential scanning fluorimetry (DSF) to investigate the interaction of guanosine nucleotides (GNPs) with DmsD. Here we have shown highly cooperative binding of DmsD with GTP. A dissociative ligand-binding style isotherm was generated upon GTP titration into the DmsD::DmsAL interaction, yielding sigmoidal release of DmsD with a Hill coefficient of 2.09 and a dissociation constant of 0.99 mM. DSF further illustrated the change in thermal stability upon DmsD...
Source: Biochemical and Biophysical Research communications - August 20, 2015 Category: Biochemistry Authors: Cherak SJ, Turner RJ Tags: Biochem Biophys Res Commun Source Type: research

Elevated IL-3 and IL-12p40 levels in the lower airway of infants with RSV-induced bronchiolitis correlate with recurrent wheezing.
Abstract Respiratory Syncytial Virus (RSV) is the first cause of hospitalization due to bronchiolitis in infants. RSV bronchiolitis has been linked to asthma and recurrent wheezing, however the mechanisms behind this association have not been elucidated. Here, we evaluated the cytokine and chemokine profiles in the airways in infants with RSV bronchiolitis. Nasopharyngeal Aspirates (NPA) and Bronchoalveolar Lavage Fluids (BALF) from infants hospitalized due to RSV bronchiolitis and healthy controls were analyzed for cytokine and chemokine production. We observed elevated levels of Th2 cytokines (IL-3, IL-4, IL-10 a...
Source: Cytokine - August 20, 2015 Category: Molecular Biology Authors: Bertrand P, Lay MK, Piedimonte G, Brockmann PE, Palavecino CE, Hernández J, León MA, Kalergis AM, Bueno SM Tags: Cytokine Source Type: research

Tracheostomy in neurologically compromised paediatric patients: role of starplasty.
CONCLUSION: Patients with primary neurological diagnoses have low rates of decannulation; starplasty tracheostomy should be considered for these patients. Patients with seizure disorder or acute neurological injury tended to have a higher short-term decannulation rate; traditional tracheostomy is recommended in these patients. PMID: 26279145 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - August 19, 2015 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Src and epidermal growth factor receptor mediate the pro-invasive activity of Bcl-w
Abstract Members of the Bcl-2 family are established regulators of cell death. However, recent studies have shown that they can also regulate cell migration, invasion, and cancer metastasis. These functions of cancer cells are promoted by pro-survival Bcl-2 proteins (Bcl-2, Bcl-XL, and Bcl-w) but are suppressed by pro-apoptotic members (Bax and Bak). We have previously shown that Bcl-w and Bcl-XL enhance the ability of respiratory complex-I to produce reactive oxygen species (ROS), stimulating the phosphoinositide 3-kinase (PI3K)-dependent invasion pathway. Here, we show that Bcl-w overexpression increases the pho...
Source: Tumor Biology - August 19, 2015 Category: Cancer & Oncology Source Type: research

Using Cardiac Biomarkers in Veterinary Practice
Blood-based assays for various cardiac biomarkers can assist in the diagnosis of heart disease in dogs and cats. The two most common markers are cardiac troponin-I and N-terminal pro-B–type natriuretic peptide. Biomarker assays can assist in differentiating cardiac from noncardiac causes of respiratory signs and detection of preclinical cardiomyopathy. Increasingly, studies indicate that cardiac biomarker testing can help assess the risk of morbidity and mortality in animals with heart disease. Usage of cardiac biomarker testing in clinical practice relies on proper patient selection, correct interpretation of test resul...
Source: Clinics in Laboratory Medicine - August 19, 2015 Category: Laboratory Medicine Authors: Mark A. Oyama Source Type: research

Bedside placement of an endobronchial valve to aid invasive ventilation and weaning from extracorporeal membrane oxygenation.
We describe the use of an endobronchial oneway valve, placed at the bedside via flexible bronchoscopy, to treat a BPF in a patient with hypoxic respiratory failure, supported by extracorporeal membrane oxygenation (ECMO), secondary to pneumonia. We believe that this is the first published description of this technique being used in a patient needing ECMO support. PMID: 26282263 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - August 19, 2015 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

High-flow nasal cannula use in a paediatric intensive care unit over 3 years.
CONCLUSION: HFNC therapy was successful in most patients. Most failures occurred within 8.25 hours. Use of HFNC for heart disease was associated with a high therapy failure rate (50%). PMID: 26282258 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - August 19, 2015 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Persistent critical illness characterised by Australian and New Zealand ICU clinicians.
CONCLUSION: Patients with PerCI appear to be an identifiable group of ICU patients, with definable characteristics, substantial stress associated with their care, and poor perceived long-term outcomes. PMID: 26282252 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - August 19, 2015 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Increased liver stiffness in idiopathic pulmonary fibrosis: a pilot study.
CONCLUSIONS: To our knowledge, this is the first report suggesting that liver stiffness is increased in more than one-third of IPF patients. Application of novel methodologies should be encouraged for investigating further IPF. PMID: 26278699 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Acute eosinophilic pneumonia associated with glyphosate-surfactant exposure.
We report a case of a female patient who developed acute eosinophilic pneumonia (AEP) after recent onset of smoking and exposure to glyphosate-surfactant.The additional exposure associated with the recent start of smoking may have contributed to the development and/or severity of AEP.A clinical relapse after re-challenge four years later both with smoking and glyphosate-surfactant made the association highly likely.Respiratory distress is a factor of poor outcome and mortality after ingestion of glyphosate-surfactant.This case highlights the importance of a thorough exposure history e.g., possible occupational and environm...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Near fatal desquamative interstitial pneumonia with bilateral recurrent tension pneumothorax.
We report a rare case of near fatal DIP with recurrent bilateral tension pneumothorax despite of corticosteroid maintenance therapy. Clinical and radiological findings improved with surgical intervention in addition to combination therapy with prednisolone and clarithromycin. The patient has remained in an improved state and has been receiving prednisolone and clarithromycin for 9 months. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 167-171). PMID: 26278697 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Significance of granulomatous inflammation in usual interstitial pneumonia.
In conclusion, we present two patients in whom a diagnosis of sarcoidosis preceded the diagnosis of UIP by 20 years or more. The subsequent course of disease in both patients was consistent with Idiopathic Pulmonary Fibrosis (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 160-166). PMID: 26278696 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Bone mineral density in patients with interstitial lung disease.
CONCLUSIONS: We observed a high prevalence of osteoporosis and osteopenia among newly diagnosed ILD patients. Our findings suggest that there is a substantially increased risk of osteoporosis and that early screening and aggressive treatment with various anti-bone resorptive therapies are necessary in ILD patients. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 151-159). PMID: 26278695 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Estimation using the impulse oscillation system in patients with pulmonary sarcoidosis.
CONCLUSIONS: IOS parameters were found to be significantly correlated with pulmonary function parameters and the airway wall thickness in pulmonary sarcoidosis patients.  IOS is considered to be useful for detecting early manifestations of airflow limitation in pulmonary sarcoidosis patients. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 144-150). PMID: 26278694 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Cigarette smoking and male sex are independent and age concomitant risk factors for the development of ocular sarcoidosis in a New Orleans sarcoidosis population.
CONCLUSION: To date, there are few dedicated investigations of risk factors for OS, especially smoking. This investigation identified male sex, age, and tobacco exposure as independent risk factors for OS. Though disease duration did not withstand regression analysis in this moderately sized group, age at chart review suggests screening for OS should not remit but rather intensify in aging patients with sarcoidosis. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 183-143). PMID: 26278693 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Comparison of clinical characteristics and outcomes between combined pulmonary fibrosis and emphysema associated with usual interstitial pneumonia pattern and non-usual interstitial pneumonia.
CONCLUSIONS: This study demonstrated that the presence of UIP pattern and high-CPI in CPFE patients were associated with poorer mortality. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 129-137). PMID: 26278692 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A score for estimating survival in idiopathic pulmonary fibrosis with rest SpO2>88.
A score for estimating survival in idiopathic pulmonary fibrosis with rest SpO2>88. Sarcoidosis Vasc Diffuse Lung Dis. 2015;32(2):121-8 Authors: Soares MR, Pereira C, Ferreira R, Nei Aparecida Martins Coletta E, Silva Lima M, Muller Storrer K Abstract BACKGROUND: Prediction models for survival at baseline evaluation have been proposed in IPF but some are difficult to use. The aim of present study was to develop a new mortality risk scoring system for patients with IPF at initial evaluation. METHODS: One hundred twenty with definitive IPF were selected through a review of standardized medical rec...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

What comorbidities accompany sarcoidosis? A large cohort (n=1779) patients analysis.
CONCLUSIONS: More than half of patients with sarcoidosis have a comorbid condition, which is more likely in older patients and those with multiorgan involvement. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 115-120). PMID: 26278690 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Placenta-derived mesenchymal-like cells (PDA-001) as therapy for chronic pulmonary sarcoidosis: a phase 1 study.
CONCLUSION: The use of placental derived mesenchymal-like cells led to a mild increase in pulmonary artery pressure. In some cases, these cells were found in the BAL 24 hours after the second dose. Two of four patients demonstrated some steroid sparing benefit, including one patient with prolonged remission. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 106-114). PMID: 26278689 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Serum levels of soluble CD163 as a specific marker of macrophage/monocyte activity in sarcoidosis patients.
CONCLUSIONS: sCD163 may be used as a favorable specific marker of macrophage/monocyte activity in order to more clearly understand the disease activity of sarcoidosis. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 99-105). PMID: 26278688 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Practical management of Idiopathic Pulmonary Fibrosis.
Authors: Kishaba T Abstract  Idiopathic Pulmonary Fibrosis (IPF) is relentless progressive interstitial lung disease (ILD) of unknown etiology. Main pathogenesis is aberrant recovery of epithelial injury and collagen deposition. Majority of IPF patients have been elderly men with smokers. However, there are important differential diagnosis such as fibrotic non-specific interstitial pneumonia (NSIP), Connective Tissue Disease (CTD) associated ILD, chronic hypersensitivity pneumonia (CHP). Clinical point of view, non-productive cough and progressive exertional dyspnea are main symptoms. In addition, scalene muscle h...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Increased Expressions of Integrin Subunit β1, β2 and β3 in Patients with Acute Infection.
CONCLUSION: As the core proteins of venous thrombi, integrinβ1, β2 and β3 were markedly increased expression in patients with acute infection, which maybe explain the increased risk of VTE in acute infection patients. A weakened immune system could be the basic condition of VTE occurrence. PMID: 26283883 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - August 19, 2015 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Anesthesiologic Effects of Transperitoneal Versus Extraperitoneal Approach During Robot-Assisted Radical Prostatectomy: Results of a Prospective Randomized Study
Conclusions:This prospective randomized study demonstrates that, from the anesthesiologic viewpoint, during RARP the TP approach is preferable to EP, because of lower CO2 reabsorption and risk of acidosis. (Source: International Braz J Urol)
Source: International Braz J Urol - August 19, 2015 Category: Urology & Nephrology Source Type: research

Airway resistance and allergic sensitization in children with obstructive sleep apnea hypopnea syndrome
ConclusionsTotal airway resistance was significantly increased in Children with OSAHS. Allergic sensitization might contribute to the exacerbation of existing OSAHS in children. Large scale studies are required to further validate these findings. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - August 19, 2015 Category: Respiratory Medicine Authors: Jie Zhang, Jing Zhao, Min Chen, Shilin Liu, Xuexi Zhang, Fengzhen Zhang, Yamei Zhang, Hui Chen, Xin Ni Tags: Original Article: Sleep & Breathing Source Type: research

Mortality Risk Factors for Middle East Respiratory Syndrome Outbreak, South Korea, 2015
M. S. Majumder et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - August 19, 2015 Category: Infectious Diseases Source Type: research

The Regional Asthma Disease Management Program (RADMP) for low income underserved children in rural western North Carolina: a National Asthma Control Initiative Demonstration Project
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 19, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Ultrasound detection of pneumonia in febrile children with respiratory distress: a prospective study
Conclusion: LUS can be adopted by the clinician as a non-invasive bedside tool to expand the physical evaluation of febrile children with respiratory distress. In our study, LUS results appeared not only as reliable as CXR in detecting lung consolidations but also consistent with clinical and laboratory data. What is known: • The diagnosis of pneumonia is mainly based on physical examination plus radiologic and laboratory evaluation when needed. • Although lung ultrasound (LUS) has shown high sensitivi...
Source: European Journal of Pediatrics - August 19, 2015 Category: Pediatrics Source Type: research

Factors influencing the implementation of chronic care models: A systematic literature review
Conclusion: This systematic review demonstrated the importance of considering human factors including the influence that different stakeholders have on the success or otherwise of the implementing a CCM. (Source: BMC Family Practice)
Source: BMC Family Practice - August 19, 2015 Category: Primary Care Authors: Carol DavyJonathan BleaselHueiming LiuMaria TchanSharon PonniahAlex Brown Source Type: research

Identification of new biomarkers for Acute Respiratory Distress Syndrome by expression-based genome-wide association study
Background: Accumulated to-date gene microarray data on Acute Respiratory Distress Syndrome (ARDS) in the Gene Expression Omnibus (GEO) represent a rich source for identifying new unsuspected targets and mechanisms of ARDS. The recently developed expression-based genome-wide association study (eGWAS) for analysis of GEO data was successfully used for analysis of gene expression of comparatively noncomplex adipose tissue, 75 % of which is represented by adipocytes. Although lung tissue is more heterogenic and does not possess a prevalent cell type for driving gene expression patterns, we hypothesized that eGWAS of ARDS sam...
Source: BMC Pulmonary Medicine - August 19, 2015 Category: Respiratory Medicine Authors: Dmitry GrigoryevDilyara CheranovaSuman ChaudharyDaniel HeruthLi ZhangShui Ye Source Type: research

Quantitative analysis of pathogens in the lower respiratory tract of patients with chronic obstructive pulmonary disease
Conclusions: These findings suggest that increased bacterial loads mediated inflammatory response in the lower respiratory tract and were associated with AECOPD. In addition, these results provide guidance for antibiotic therapy of AECOPD patients. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 19, 2015 Category: Respiratory Medicine Authors: Huaying WangXiao GuYuesong WengTao XuZhongming FuWeidong PengWanjun Yu Source Type: research

Peak oxygen uptake and breathing pattern in COPD patients – a four-year longitudinal study
Background: Activities of daily living in patients with chronic obstructive pulmonary disease (COPD) are limited by exertional dyspnea and reduced exercise capacity. The aims of the study were to examine longitudinal changes in peak oxygen uptake (V̇O 2peak ), peak minute ventilation (V̇ Epeak ) and breathing pattern over four years in a group of COPD patients, and to examine potential explanatory variables of change. Methods: This longitudinal study included 63 COPD patients, aged 44-75 years, with a mean forced expiratory volume in one second (FEV 1 ) at ba...
Source: BMC Pulmonary Medicine - August 19, 2015 Category: Respiratory Medicine Authors: Bente FriskJon HardieBirgitte EspehaugLiv StrandRolf Moe-NilssenTomas EaganPer BakkeEinar Thorsen Source Type: research

Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis
Conclusions: Our results suggest that hospital registries are inaccurate for epidemiological studies unless patients are carefully re-evaluated. IPF is diagnosed in Finland at a stage when lung function is still quite well preserved. Smoking in patients with IPF was less common than in previous reports. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 19, 2015 Category: Respiratory Medicine Authors: Jaana KaunistoK. KelloniemiE. SutinenU. HodgsonA. PiilonenR. KaarteenahoR. MäkitaroM. PurokiviE. Lappi-BlancoS. SaarelainenH. KankaanrantaA. MursuM. KanervistoE-R. SalomaaM. Myllärniemi Source Type: research

Roflumilast for asthma: Efficacy findings in mechanism of action studies
Conclusions The results from these studies indicate that the anti-inflammatory effects of roflumilast observed in COPD are also seen in asthma and advance our understanding of its mechanism of action. All studies were funded by Takeda. Trial registration numbers available on ClinicalTrials.gov: NCT01365533. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 19, 2015 Category: Respiratory Medicine Source Type: research