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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Intrapulmonary Solitary Fibrous Tumors: Benign or Malignant?
PMID: 26195157 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - July 17, 2015 Category: Respiratory Medicine Authors: Schiavoni E, Alvarez Padilla F, Bustos M Tags: Arch Bronconeumol Source Type: research

Restrictive Fluid Resuscitation Leads to Better Oxygenation than Non-Restrictive Fluid Resuscitation in Piglets with Pulmonary or Extrapulmonary Acute Respiratory Distress Syndrome.
CONCLUSIONS RFR led to better oxygenation in ARDSp and ARDSexp compared with NRFR, but fluid restriction improved oxygenation in ARDSexp only. PMID: 26166324 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - July 16, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Effect of dobutamine on extravascular lung water index, ventilator function, and perfusion parameters in acute respiratory distress syndrome associated with septic shock
Artificial Cells, Nanomedicine, and Biotechnology, Ahead of Print. (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - July 16, 2015 Category: Biotechnology Tags: article Source Type: research

Discovery of 1,2,4-Triazole-1,3-Disulfonamides as Dual Inhibitors of Mitochondrial Complex II and Complex III
New J. Chem., 2015, Accepted ManuscriptDOI: 10.1039/C5NJ00215J, PaperHua Cheng, Yan-Qing Shen, Xia-Yan Pan, Yi-Ping Hou, Qiongyou Wu, GF YangThe respiratory chain succinate-ubiquinone oxidoreductase (SQR or complex II) and ubihydroquinone-cytochrome (cyt) c oxidoreductase (cyt bc1 or complex III) have been demonstrated as the promising targets of numerous antibiotics and...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - July 16, 2015 Category: Chemistry Authors: Hua Cheng Source Type: research

Injuries following a serious hydrofluoric acid leak: First aid and lessons
This article describes the events that took place leading to casualties as well as presenting the first-aid experience and the lessons learnt from this kind of mass injury. (Source: Burns)
Source: Burns - July 16, 2015 Category: Dermatology Source Type: research

Computed tomographic assessment of airflow obstruction in smoke inhalation injury: Relationship with the development of pneumonia and injury severity
Conclusions These data revealed the utility of computed tomography scanning on admission to show that the patients with smoke inhalation injury had airway wall thickening compared to control patients without smoke inhalation injury. Airflow narrowing due to airway wall thickening was related to the development of pneumonia and the number of mechanical ventilation days in patients with smoke inhalation injury. Airflow narrowing is one important factor of respiratory deterioration in smoke inhalation injury. (Source: Burns)
Source: Burns - July 16, 2015 Category: Dermatology Source Type: research

Reconstruction of thoracic burn sequelae by scar release and flap resurfacing
Conclusions Scar releases and flaps provide a safe and effective method for the correction of restricted thoracic expansion, respiratory restriction, decreased range of shoulder motion, and discomfort from thoracic burn sequelae. (Source: Burns)
Source: Burns - July 16, 2015 Category: Dermatology Source Type: research

Nrf2 activators modulate oxidative stress responses and bioenergetic profiles of human retinal epithelial cells cultured in normal or high glucose conditions
Publication date: Available online 15 July 2015 Source:Pharmacological Research Author(s): Roberta Foresti, Claudio Bucolo, Chiara Maria Bianca Platania, Filippo Drago, Jean-Luc Dubois-Randé, Roberto Motterlini Retinal pigment epithelial cells exert an important supporting role in the eye and develop adaptive responses to oxidative stress or high glucose levels, as observed during diabetes. Endogenous antioxidant defences are mainly regulated by Nrf2, a transcription factor that is activated by naturally-derived and electrophilic compounds. Here we investigated the effects of the Nrf2 activators dimethylfumarate (...
Source: Pharmacological Research - July 16, 2015 Category: Drugs & Pharmacology Source Type: research

Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status
Conclusion Reduced mitochondrial respiratory capacity in white adipocytes is a hallmark of murine obesity irrespective of the glucose tolerance status. Impaired respiratory capacity in white adipocytes solely is not sufficient for the development of systemic glucose intolerance. Graphical abstract (Source: Molecular Metabolism)
Source: Molecular Metabolism - July 16, 2015 Category: Endocrinology Source Type: research

Gastrointestinal variant of Lemierre's syndrome complicating ruptured appendicitis
We describe a case of F. necrophorum bacteremia associated with suppurative porto-mesenteric vein thrombosis (PVT) following acute ruptured appendicitis. In addition, we list the documented twelve cases of Fusobacterium pylephlebitis. Recanalization of the porto-mesenteric veins and relief of the extrahepatic portal hypertension were achieved with early empiric antibiotic and local thrombolytic therapy. Our patient's case underscores the importance of recognizing Fusobacterium bacteremia as a possible cause of suppurative PVT after disruption of the gastrointestinal mucosa following an acute intraabdominal infectious proce...
Source: IDCases - July 16, 2015 Category: Infectious Diseases Source Type: research

Proteomic analysis of cell wall in four pathogenic species of Candida exposed to oxidative stress
Publication date: Available online 15 July 2015 Source:Microbial Pathogenesis Author(s): Mayra Denisse Ramírez-Quijas, Everardo López-Romero, Mayra Cuéllar-Cruz In order for Candida species to adhere and colonize human host cells they must express cell wall proteins (CWP) and adapt to reactive oxygen species (ROS) generated by phagocytic cells of the human host during the respiratory burst. However, how these pathogens change the expression of CWP in response to oxidative stress (OSR) is not known. Here, fifteen moonlight-like CWP were identified that expressed differentially in four species of Candida after they w...
Source: Microbial Pathogenesis - July 16, 2015 Category: Infectious Diseases Source Type: research

Pulmonary Hypertension in Heart Failure: Epidemiology, Right Ventricular Function and Survival.
CONCLUSIONS: Cpc-PH is rare in chronic heart failure. Right ventricular-pulmonary vascular coupling is poor in Cpc-PH, and might serve as one explanation of dismal outcomes. PMID: 26181215 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 16, 2015 Category: Respiratory Medicine Authors: Gerges M, Gerges C, Pistritto AM, Lang MB, Trip P, Jakowitsch J, Binder T, Lang IM Tags: Am J Respir Crit Care Med Source Type: research

Aberrant DNA Methylation of Phosphodiesterase 4D: Effect on Airway Smooth Muscle Cell Phenotypes.
In this study, we aimed to examine the relationship between epigenetic regulation of PDE4D and ASMC phenotypes. We identified CpG site-specific hypomethylation at PDE4D promoter in human asthmatic ASMCs. We next utilized methylated oligonucleotides to introduce CpG site-specific methylation at PDE4D promoter and examined its effect on ASMCs. We showed that PDE4D methylation decreased cell proliferation and migration of asthmatic ASMCs. We further elucidated that by showing methylated PDE4D decreased PDE4D expression in asthmatic ASMCs, increased cAMP level and inhibited the aberrant increase in Ca2+ level. Moreover, PDE4D ...
Source: Am J Respir Cell Mol... - July 16, 2015 Category: Respiratory Medicine Authors: Lin AH, Shang Y, Mitzner W, Sham JS, Tang WY Tags: Am J Respir Cell Mol Biol Source Type: research

Pulmonary epithelioid inflammatory myofibroblastic sarcoma with multiple bone metastases: case report and review of literature
We report here a case of unusual pulmonary EIMS with multiple bone metastases. A 21-year-old Chinese male patient presented with complaints of general fatigue and rapid weight loss, and a huge tumor arising in the left lower lobe of lung was detected by chest computed tomography. The mass of lung was totally resected. Microscopically, the tumor cells were rounded and epithelioid in shape. Myxoid stroma and inflammatory infiltration was also present. The tumor cells were immunopositive to anaplastic lymphoma kinase (ALK) in smooth cytoplasmic pattern. Fluorescence in situ hybridization (FISH) assay revealed the presence of ...
Source: Diagnostic Pathology - July 16, 2015 Category: Pathology Authors: Xinge FuJuhong JiangXiao-ying TianZhi Li Source Type: research

Advances in molecular biology of lung disease: Aiming for precision therapy in NSCLC.
Abstract Lung cancer is the principal cause of cancer related mortality in the developed world, accounting for almost one quarter of all cancer deaths. Traditional treatment algorithms largely relied on histological subtype and comprised pragmatic chemotherapy regimes with limited efficacy. However, as our understanding of the molecular basis of disease in NSCLC has improved exponentially it has become apparent that NSCLC can be radically subdivided, or molecularly characterised on the basis of recurrent 'driver' mutations occurring in specific oncogenes. We know that the presence of such mutations leads to constit...
Source: Chest - July 16, 2015 Category: Respiratory Medicine Authors: Rooney C, Sethi T Tags: Chest Source Type: research

Rebuttal From Dr. Punjabi.
Abstract It is quite reasonable to advocate that the apnea-hypopnea index (AHI) is a clinically valuable metric for obstructive sleep apnea (OSA) on the basis that patients with a high AHI have a higher prevalence of excessive sleepiness, hypertension, and cardiovascular disease compared to those with a lower AHI. Moreover, the contention that the AHI is a "marker of disease" is also sound given that clinical symptoms improve or resolve when the AHI decreases with treatment. However, these arguments only suggest that the AHI is, at best, a crude metric for OSA. Indeed, Dr. Rappaport's conclusion that the AHI is use...
Source: Chest - July 16, 2015 Category: Respiratory Medicine Authors: Punjabi NM Tags: Chest Source Type: research

Rebuttal From Dr. Rapoport.
Abstract In his editorial Dr. Punjabi points out intrinsic limitations of the AHI concept: the cycle rate of events does not capture physiological "severity" of each event (eg, quantitative flow reduction, event duration) or biological impact (eg. degree of desaturation, sympathetic activation); temporal distribution of events is not captured (eg clusters of apnea/hypopnea are counted equally to widely separated individual events); other essential aspects of sleep are ignored (eg total duration of sleep determines overall exposure to sleep disordered breathing). Thus, he argues AHI is an overly simplistic represent...
Source: Chest - July 16, 2015 Category: Respiratory Medicine Authors: Rapoport DM Tags: Chest Source Type: research

Counterpoint: Is the AHI the best way to quantify the severity of sleep disordered breathing? No.
Abstract Since the early clinical descriptions of obstructive sleep apnea in the 1970s, our understanding of the pathogenesis and adverse consequences of this chronic disease has advanced substantially. Initially, the primary focus was the recognition of sleep-related apneic events which were observed to severely fragment sleep, induce cardiovascular instability, and lead to excessive sleepiness during the day. Given the significant hemodynamic and sleep-related effects of obstructive apneas during sleep, it comes as no surprise that the "apnea index", which tallies the number of apneas per hour of sleep, became th...
Source: Chest - July 16, 2015 Category: Respiratory Medicine Authors: Punjabi NM Tags: Chest Source Type: research

Point: Is the AHI the best way to quantify the severity of sleep disordered breathing? - YES.
Abstract Over the past 30 years, we have come to appreciate that during sleep there is a spectrum of obstructive breathing physiology ranging from mild snoring to severe obstructive sleep apnea syndrome. By some estimates significant abnormalities of breathing during sleep may affect as much as 15-20% of the adult population and 5-10% of children. The obesity epidemic makes it likely that these numbers will only increase. PMID: 26181884 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 16, 2015 Category: Respiratory Medicine Authors: Rapoport DM Tags: Chest Source Type: research

Clinical characteristics and outcomes in extreme elderly (age ≥85) Japanese patients with atrial fibrillation: The Fushimi AF Registry.
Conclusions: In our community-based prospective cohort, Japanese extreme elderly AF patients had a higher incidence of stroke but similar major bleeding risks compared with the younger AF population. Trial Registry: UMIN Clinical Trials Registry; No.: UMIN000005834; URL: http://www.umin.ac.jp/ctr/index.htm. PMID: 26181726 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 16, 2015 Category: Respiratory Medicine Authors: Yamashita Y, Hamatani Y, Esato M, Chun YH, Tsuji H, Wada H, Hasegawa K, Abe M, Lip GY, Akao M Tags: Chest Source Type: research

Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice
Conclusions: These results demonstrate that SCGB3A2 is an anti-fibrotic agent, and suggest a possible therapeutic use of recombinant SCGB3A2 in the treatment of pulmonary fibrosis. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - July 16, 2015 Category: Respiratory Medicine Authors: Yan CaiMitsuhiro YonedaTakeshi TomitaReiko KurotaniMinoru OkamotoTaketomo KidoHiroyuki AbeWayne MitznerArjun GuhaShioko Kimura Source Type: research

Randomised, double-blind, placebo-controlled crossover study to investigate different dosing regimens of olodaterol delivered via Respimat ® in patients with moderate to severe persistent asthma
Background: A Phase II, multicentre, randomised, double-blind, placebo-controlled, crossover trial comparing the 24-h forced expiratory volume in 1 s (FEV 1 ) time profile after 3 weeks’ treatment with once-daily (QD) or twice-daily (BID) olodaterol (at the same total daily dose) versus placebo delivered via Respimat ® in patients with moderate to severe asthma. Methods: Patients were randomised to different sequences of olodaterol with 2-week washout, either as a total daily dose of 5 μg (5 μg QD [AM] or 2.5 μg BID) or placebo, or 10 μg (10 μg QD [AM] or 5 μg BID...
Source: Respiratory Research - July 16, 2015 Category: Respiratory Medicine Authors: Kai-Michael BeehCraig LaForceMartina GahlemannArne WenzRobert ToorawaMatja¿ Fle¿ar Source Type: research

Prevalence of Eosinophilia in Hospitalized Patients with Asthma Exacerbation
Recent studies have identified the “eosinophilic phenotype” of asthma that is characterized by persistent eosinophilic inflammation and frequent exacerbations. However, the prevalence of eosinophilia in patients hospitalized for asthma exacerbation is not known. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 16, 2015 Category: Respiratory Medicine Authors: Kohei Hasegawa, Samantha J. Stoll, Jason Ahn, Jane C. Bittner, Carlos A. Camargo Tags: Short communication Source Type: research

Improvements in lung function with umeclidinium/vilanterol versus fluticasone propionate/salmeterol in patients with moderate-to-severe COPD and infrequent exacerbations
We read with interest the article by James F. Donohue et al, which summarized the results of two identical studies on the once-daily (od) long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) combination, vilanterol (VIL)/umeclidinium (UMEC) and the twice-daily (bid) LABA/inhaled corticosteroid (ICS) combination salmeterol (SAL)/fluticasone propionate (FP). The primary endpoint was least squares mean change from baseline in 0 to 24-h weighted mean FEV1 versus FP/SAL on Day 84 in patients with moderate-to-severe COPD, without a documented history of COPD exacerbation in the year before screening [1]. (Sour...
Source: Respiratory Medicine CME - July 16, 2015 Category: Respiratory Medicine Authors: Donald Banerji, Francesco Patalano Tags: Correspondence Source Type: research

Long-term improvement of lung clearance index in patients with mild cystic fibrosis lung disease: Does hypertonic saline play a role?
To assess whether long-term inhalation with hypertonic saline is able to halt the progression of mild CF lung disease, we analysed longitudinal data of lung clearance index (LCI) and spirometry. A total of 34 patients with mild lung disease (FEV1≥70% of predicted) had at least one LCI result before and ≥2 LCI measurements after start of hypertonic saline (HS) therapy. After a mean follow-up of 39.7 (SD 7.4) months after starting HS, LCI improved significantly from 7.89 (SD 1.35) at baseline to 6.96 (SD 1.03), and 19/34 patients had a normal LCI value at the last measurement. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 16, 2015 Category: Respiratory Medicine Authors: Helmut Ellemunter, Johannes Eder, Susanne Fuchs, Monika Gappa, Gratiana Steinkamp Tags: Short Communication Source Type: research

A semi-blinded study comparing 2 methods of measuring nasal potential difference: Subcutaneous needle versus dermal abrasion
According to European and US protocols, two nasal potential difference (NPD) measurement methods are considered acceptable, although they have not been formally compared: subcutaneous agar-filled needle with calomel (Ndl) and dermal abrasion with conducting cream and Ag/AgCl electrodes (Abr). We compared both in CF and healthy volunteers (HV), assessing their discriminative value and subject's preference. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 16, 2015 Category: Respiratory Medicine Authors: E. De Wachter, I. De Schutter, A. Meulemans, R. Buyl, A. Malfroot Tags: Original Article Source Type: research

Evaluation of risk factors of ventilator associated pneumonia on outcome of acute exacerbation of chronic obstructive pulmonary disease
Conclusions Old age, late onset VAP, re-intubation and prolonged use of antibiotics were predictors of mortality in VAP patients with AECOPD. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - July 16, 2015 Category: Respiratory Medicine Source Type: research

Delayed diagnosis of hemoptysis in the case of prior aortic coarctation repair: a case report of aortobronchial fistula
We report a case of a 46-year old man who presented with spontaneous bright red blood per mouth for several months. The patient had history of aortic coarctation repair at age 17. Endoscopy and nasopharyngeoscopy revealed no source of bleeding. Computed tomography scan revealed the presence of thoracic aortic pseudoaneurysm with the formation of an aortobronchial fistula (ABF). This case illustrates the high index of suspicion for ABF in the case of hemoptysis or hematemesis with prior history of coarctation repair. Furthermore, we discuss the role of thoracic endovascular aneurysm repair (TEVAR) as the standard of repair ...
Source: Respiratory Medicine Case Reports - July 16, 2015 Category: Respiratory Medicine Source Type: research

Tuberculosis mimicking lung cancer
Publication date: 2015 Source:Respiratory Medicine Case Reports, Volume 16 Author(s): I. Hammen Tuberculosis (TB) is well known as a diagnostic chameleon and can resemble malignancy. In thorax TB can be manifested as pulmonary infiltrates and/or mediastinal lymphadenopathy. In low incident countries with high incidence of lung cancer and varying clinical presentations, TB often gets misdiagnosed with the result of delayed treatment start and unnecessary diagnostic procedures. Our case report presents two patients, who were referred to the Thorax diagnostic centre at the Department of Respiratory Medicine, Odense Univers...
Source: Respiratory Medicine Case Reports - July 16, 2015 Category: Respiratory Medicine Source Type: research

Non-small cell lung cancer in octogenarian patients – The experience in a tertiary university hospital
Publication date: Available online 15 July 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): H. Dabó, R. Gomes, V. Hespanhol, H. Queiroga (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - July 16, 2015 Category: Respiratory Medicine Source Type: research

Lung disease in primary antibody deficiency
We describe the major PAD syndromes, with a particular focus on common variable immunodeficiency (CVID). Respiratory infection is a common presenting feature of PAD syndromes. Respiratory complications are frequent and responsible for much of the morbidity and mortality associated with these syndromes. Respiratory complications include acute infections, the sequelae of infection (eg, bronchiectasis), non-infectious immune-mediated manifestations (notably the development of granulomatous-lymphocytic interstitial lung disease in CVID), and an increased risk of lymphoma. Although minor abnormalities are detectable in the lung...
Source: The Lancet Respiratory Medicine - July 16, 2015 Category: Respiratory Medicine Source Type: research

Burgeoning burden of non-communicable diseases in Nepal: a scoping review
This study reviews existing evidence on the burden of non-communicable diseases in Nepal using the framework developed by Arksey and O’Malley for scoping reviews. A total of 110 articles were identified from database searches, and four from additional searches. The titles and abstracts were reviewed using predetermined screening criteria. We limited our search to existing literature in English language and included all studies regardless of year of study. Both observational and interventional studies were included. Studies conducted outside Nepal and studies not reporting prevalence of NCDs were excluded. Additionally, w...
Source: Globalization and Health - July 16, 2015 Category: Global & Universal Authors: Shiva MishraDinesh NeupaneParash BhandariVishnu KhanalPer Kallestrup Source Type: research

Domestic use of bleach and infections in children: a multicentre cross-sectional study
Conclusions Passive exposure to cleaning bleach in the home may have adverse effects on school-age children's health by increasing the risk of respiratory and other infections. The high frequency of use of disinfecting irritant cleaning products may be of public health concern, also when exposure occurs during childhood. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - July 16, 2015 Category: Occupational Health Authors: Casas, L., Espinosa, A., Borras-Santos, A., Jacobs, J., Krop, E., Heederik, D., Nemery, B., Pekkanen, J., Hyvarinen, A., Taubel, M., Zock, J.-P. Tags: Press releases Environment Source Type: research

A systematic review of the association between pleural plaques and changes in lung function
Conclusions The presence of pleural plaques is associated with a small, but statistically significant mean difference in FVC and FEV1 in comparison to asbestos-exposed individuals without plaques or other abnormalities. From a public health perspective, small group mean decrements in lung function coupled with an increased rate of decline in lung function of the exposed population may be consequential. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - July 16, 2015 Category: Occupational Health Authors: Kopylev, L., Christensen, K. Y., Brown, J. S., Cooper, G. S. Tags: Respiratory Review Source Type: research

A06 San Pedro Bay Ports Clean Air Analysis
Conclusions The success of the Clean Trucks Program indicates that the initiatives taken by the Ports through their Clean Air Action Plan have been able to improve the quality of life of citizens exposed to pollution from the Ports. However, previous works suggest that these impacts are small compared to those of port-related truck and train operations on land, outside of the San Pedro Bay Ports complex. (Source: Journal of Transport and Health)
Source: Journal of Transport and Health - July 16, 2015 Category: Occupational Health Source Type: research

A08 The evaluation of research impact on transport and health in five non-communicable disease areas as reported in a UK newspaper
Conclusions Transport affects human health in positive and negative ways. For example, recent legislation (December 2014) that provides for a smoking ban in cars in the presence of children has been receiving repeated reporting in the press since 2009 by experts seeking to create this law. Transport policy can thus affect any of these five NCDs and influence individuals on making choices about using different forms of transport or choosing where they live. (Source: Journal of Transport and Health)
Source: Journal of Transport and Health - July 16, 2015 Category: Occupational Health Source Type: research

Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies
Deficiencies in respiratory-chain complexes lead to a variety of clinical phenotypes resulting from inadequate energy production by the mitochondrial oxidative phosphorylation system. Defective expression of mtDNA-encoded genes, caused by mutations in either the mitochondrial or nuclear genome, represents a rapidly growing group of human disorders. By whole-exome sequencing, we identified two unrelated individuals carrying compound heterozygous variants in TRMT5 (tRNA methyltransferase 5). TRMT5 encodes a mitochondrial protein with strong homology to members of the class I-like methyltransferase superfamily. (Source: The A...
Source: The American Journal of Human Genetics - July 16, 2015 Category: Genetics & Stem Cells Authors: Christopher A. Powell, Robert Kopajtich, Aaron R. D’Souza, Joanna Rorbach, Laura S. Kremer, Ralf A. Husain, Cristina Dallabona, Claudia Donnini, Charlotte L. Alston, Helen Griffin, Angela Pyle, Patrick F. Chinnery, Tim M. Strom, Thomas Meitinger, Tags: Report Source Type: research

Sensors, Vol. 15, Pages 17258-17273: Infrared Thermography to Evaluate Heat Tolerance in Different Genetic Groups of Lambs
Heat stress is considered a limiting factor for sheep production. We used information from physiological characteristics linked to heat tolerance to determine whether infrared thermography temperatures were able to separate groups of animals and determine the most important variables in this differentiation. Forty-eight four-month-old male lambs from eight genetic groups were used. Physiological (rectal temperature–RT, heart rate–HR, respiratory rate–RR) and blood traits, infrared thermography temperatures, heat tolerance indices, body measurements, weight and carcass traits were measured. Statistical analyses includ...
Source: Sensors - July 16, 2015 Category: Biotechnology Authors: Concepta McManusEliandra BianchiniTiago PaimFlavia de LimaJosé NetoMarlos CastanheiraGeisa EstevesCaio CardosoVanessa Dalcin Tags: Article Source Type: research

Outer membrane protein P1 is the CEACAM‐binding adhesin of Haemophilus influenzae
Summary Haemophilus influenzae is a Gram‐negative pathogen colonizing the upper respiratory tract mucosa. H. influenzae is one of several human‐restricted bacteria, which bind to carcinoembryonic antigen related cell adhesion molecules (CEACAMs) on the epithelium leading to bacterial uptake by the eukaryotic cells. Adhesion to CEACAMs is thought to be mediated by the H. influenzae outer membrane protein (OMP) P5. However, CEACAMs still bound to H. influenzae lacking OMP P5 expression, and soluble CEACAM receptor ectodomains failed to bind to OMP P5, when heterologously expressed in E. coli. Screening of a panel of H. i...
Source: Molecular Microbiology - July 16, 2015 Category: Microbiology Authors: Arnaud Kengmo Tchoupa, Sabine Lichtenegger, Joachim Reidl, Christof R. Hauck Tags: Research Article Source Type: research

European porcine reproductive and respiratory syndrome research awards
BOEHRINGER Ingelheim Animal Health has announced that it intends to fund three research projects on porcine reproductive and respiratory syndrome (PRRS) to a total of 75,000. Submissions for the 2015 European PRRS Research Award are open until July 31. With the aim of encouraging work on practical approaches to manage this disease, Boehringer Ingelheim will be providing three grants of 25,000 to fund research proposals that will generate new information to better understand the disease as well as promoting interaction among researchers and veterinarians. The company's aim is to enhance communication within the industry on ...
Source: Veterinary Record - July 16, 2015 Category: Veterinary Research Tags: Gazette Source Type: research

Oak processionary moth (Thaumetopoea processionea)
THE Forestry Commission has brought to our attention reports of horses, in the Chessington area of Kingston upon Thames, with skin irritation suspected to be due to contact with caterpillars of oak processionary moths (OPM) (Fig 1). It is possible that other animals, especially dogs and possibly livestock, may present with skin irritations, and we would like to raise awareness of the hazard of OPM. The Forestry Commission has since removed the caterpillar nests that were thought to be responsible for the horses' irritations. Labial angio-oedema, ptyalism, tongue swelling, stomatitis, conjunctivitis, gagging, vomiting ...
Source: Veterinary Record - July 16, 2015 Category: Veterinary Research Authors: Carson, A., Irvine, R., Foster, A. P. Tags: Letters Source Type: research

Evaluation and application of a one-step duplex real-time reverse transcription polymerase chain reaction assay for the rapid detection of influenza A (H7N9) virus from poultry samples
In this study, a one-step duplex real-time reverse transcription polymerase chain reaction (RRT-PCR) assay was developed for the simultaneous detection of the hemagglutinin (HA) and neuraminidase (NA) genes of the H7N9 virus for effective surveillance and early diagnosis of cases from clinical samples collected from live-poultry markets or poultry farms. The detection limit of this assay was as low as 0.1 EID50 of H7N9 viruses, which is similar to the detection limit of the real-time RT-PCR assay released by the Word Health Organization. The coefficients of variation (CVs) of both inter-assay and intra-assay reproducibilit...
Source: Archives of Virology - July 16, 2015 Category: Virology Source Type: research