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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Cholinergic epithelial cell with chemosensory traits in murine thymic medulla
Abstract Specialized epithelial cells with a tuft of apical microvilli (“brush cells”) sense luminal content and initiate protective reflexes in response to potentially harmful substances. They utilize the canonical taste transduction cascade to detect “bitter” substances such as bacterial quorum-sensing molecules. In the respiratory tract, most of these cells are cholinergic and are approached by cholinoceptive sensory nerve fibers. Utilizing two different reporter mouse strains for the expression of choline acetyltransferase (ChAT), we observed intense labeling of a subset of thymic medullary cells. ChAT...
Source: Cell and Tissue Research - October 9, 2014 Category: Cytology Source Type: research

Sudden Unexpected Death in Epilepsy: Addressing the Challenges
Abstract Epilepsy is associated with a higher rate of premature death than the general population, and the commonest cause of epilepsy mortality is sudden unexpected death in epilepsy (SUDEP). It is difficult to quantify because of the variable reporting of this cause of death. Death occurs due to autonomic deregulation of cardio-respiratory pathways as a result of seizures. Measures to reduce cardio-respiratory dysfunction are discussed together with the importance of seizure control in preventing SUDEP. The role of seizure detection devices, antiepileptic drugs and the importance of providing information about ...
Source: Current Neurology and Neuroscience Reports - October 9, 2014 Category: Neuroscience Source Type: research

Diagnosis and management of nontuberculous mycobacterial lung infections
Abstract The diagnosis and management of nontuberculous mycobacterial (NTM) lung infection remains difficult even among experienced clinicians. Both the incidence and prevalence are likely expected to rise with an aging population. Careful assessment of clinical, radiologic, and microbiologic studies is warranted before initiating therapy, which is often complicated by significant drug side effects and limited sputum conversion rates. Indications to treat are best based on a number of factors, including specific NTM species, NTM lung-infection–associated symptoms, advanced bronchiectatic or cavitary disease, exp...
Source: Current Respiratory Care Reports - October 9, 2014 Category: Respiratory Medicine Source Type: research

Optic Neuropathy, Myelopathy, Anemia, and Neutropenia Caused by Acquired Copper Deficiency After Gastric Bypass Surgery
Malabsorptive bariatric surgery is rapidly becoming a major cause of copper deficiency given the increasing prevalence of these procedures for morbid obesity. Acquired copper deficiency can present with clinically significant hematologic and neurological manifestations. Although hematologic manifestations of copper deficiency are rapidly reversible, significant neurological improvement after copper supplementation therapy is unusual and many patients remain debilitated and may only experience, at best, stabilization of the neurological manifestations. Here we present a case of an undiagnosed copper deficiency several years...
Source: Journal of Clinical Gastroenterology - October 9, 2014 Category: Gastroenterology Tags: ALIMENTARY TRACT: Case Report Source Type: research

Safety and Effectiveness of Palivizumab in Children at High Risk of Serious Disease Due to Respiratory Syncytial Virus Infection: A Systematic Review
Conclusion Rates of RSV hospitalizations and RSV hospitalization-related endpoints in pediatric subjects who received prophylaxis with palivizumab were low and constant over time and across RCTs, open-label non-comparative trials, and observational studies/registries. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - October 9, 2014 Category: Infectious Diseases Source Type: research

Imaging adults on extracorporeal membrane oxygenation (ECMO)
This article will describe the imaging appearance of different ECMO circuits in adults as well as commonly encountered complications. If a CT (computed tomography) angiogram is being performed on these patients to evaluate for pulmonary embolism, the scan may be suboptimal from siphoning off of the contrast by the ECMO. In such cases, an optimal image can be obtained by lowering the flow rate of the ECMO circuit or by disabling the circuit for the duration of image acquisition. Key Points • Femoroatrial VV ECMO: femoral vein drainage cannula and right atrial return cannula. ...
Source: Insights into Imaging - October 9, 2014 Category: Radiology Source Type: research

Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough?
Conclusion Although patients treated at HV hospitals had more medical comorbidities, outcomes across a wide spectrum of quality metrics were better than at IV or LV hospital following complex HPB surgery. A 20–30 % reduction in morbidity and mortality and an 8 % reduction in hospital patient-days could be anticipated had all patients been treated at HV hospitals. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - October 9, 2014 Category: Surgery Source Type: research

Do Electronic cigarettes impart a lower potential disease burden than conventional tobacco cigarettes?: Review on e‐cigarette vapor versus tobacco smoke
ConclusionBased on the comparison of the chemical analysis of EC and TC carcinogenic profiles and association with health‐indicating parameters, ECs impart a lower potential disease burden than conventional TCs. Laryngoscope, 2014 (Source: The Laryngoscope)
Source: The Laryngoscope - October 9, 2014 Category: ENT & OMF Authors: Anne Y. Oh, Ashutosh Kacker Tags: General Otolaryngology Source Type: research

Specificity of Quantitative Latex Agglutination Assay for D-dimer in Exclusion of Pulmonary Embolism in the Emergency Department
We assessed the prevalence of elevated quantitative latex agglutination assay for D-dimer in patients in the emergency department in whom pulmonary embolism (PE) was excluded. D-dimer was normal (<230 ng/mL) in 435 (83%) of the 522 patients. D-dimer was normal in 88% of the patients with musculoskeletal or related chest pain, 74% with pleurisy or pleuritic chest pain, and 85% with upper respiratory tract infection. D-dimer was 230 to 500 ng/mL in 65 (75%) of the 87 in whom D-dimer was elevated. Clinical probability was low in 31 (48%) of the 65 patients with D-dimer levels of 230 to 500 ng/mL. D-dimer was 230 to 500 ng/...
Source: Clinical and Applied Thrombosis/Hemostasis - October 9, 2014 Category: Hematology Authors: Stein, P. D., Matta, F., Sabra, M. J., Tana, C., Gough, A., Chabala, S., Kakish, E., Tworek, J. Tags: Original Articles Source Type: research

Laboratory capability and surveillance testing for Middle East respiratory syndrome coronavirus infection in the WHO European Region, June 2013
(Source: Eurosurveillance latest news)
Source: Eurosurveillance latest news - October 9, 2014 Category: Infectious Diseases Source Type: research

Towards better‐quality research reporting in Respirology
(Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Peter Eastwood, Lieve Bultynck, Anke van Eekelen, Christel Norman Tags: EDITORIAL Source Type: research

Detecting anxiety and depression in patients diagnosed with an interstitial lung disease. Can we do better?
See article, page 1215 (Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Anne Marie Russell, Toby M Maher Tags: EDITORIAL Source Type: research

Molecular alterations in non‐small‐cell lung cancer: Perspective for targeted therapy and specimen management for the bronchoscopist
Abstract Major advances have occurred over the past decade in our understanding of lung cancer pathobiology. Increasing knowledge of molecular aberrations in lung cancer, specifically the discovery of two driver genes in pharmacologically targetable tyrosine kinases involved in growth factor receptor signalling, epidermal growth factor receptor and anaplastic lymphoma kinase, has been of major therapeutic and prognostic importance. This discovery has allowed for new, personalized approach to the management of lung cancer. Recognizing the importance of molecular signatures of lung cancer, the College of American Pathologist...
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Kasia Czarnecka‐Kujawa, Kazuhiro Yasufuku Tags: Invited review series: Update in Interventional Pulmonology Source Type: research

Classifying patients by their characteristics and clinical presentations; the use of latent class analysis
Abstract In this article, we introduce the general statistical analysis approach known as latent class analysis and discuss some of the issues associated with this type of analysis in practice. Two recent examples from the respiratory health literature are used to highlight the types of research questions that have been addressed using this approach. (Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Darren Wraith, Rory Wolfe Tags: Invited Review Series: Modern Statistical Methods in Respiratory Medicine Source Type: research

The relationship between fat‐free mass index and pulmonary hyperinflation in COPD patients
ConclusionsFFM index was weakly associated with peak exercise IC in COPD patients. However, it ceased to be an independent predictor when corrected for expiratory airflow limitation (FEV1) and lung hyperinflation at rest (rest IC). (Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Leonardo Silveira, Paulo José Zimermann Teixeira, Cassia C. Costa, Rafael M. Souza, Pietro Krauspenhar Merola, Caroline Colombo, Renata D. Marques, Danilo C. Berton Tags: ORIGINAL ARTICLE Source Type: research

The pathogenesis of pneumothorax in Birt–Hogg–Dubé syndrome: A hypothesis
The development and natural course of lung cysts in patients with Birt–Hogg–Dubé syndrome (BHD) is still unclear, and the relationship between lung cysts and pneumothorax is not fully clarified. Based on the follow‐up results of thoracic imaging in six patients with BHD, we hypothesize that decreased potential for stretching of the cysts' wall and extensive contact with the visceral pleura are probably responsible for rupture of the cyst wall resulting in increased risk for pneumothorax. (Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Paul Christiaan Johannesma, Arjan C. Houweling, Jan‐Hein T.M. Waesberghe, R.J. Jeroen A. Moorselaar, Theo M. Starink, Fred H. Menko, Pieter E. Postmus Tags: SCIENTIFIC LETTER Source Type: research

Forthcoming Meetings
(Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Tags: FORTHCOMING MEETINGS Source Type: research

Journal Statistics
(Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Tags: JOURNAL STATISTICS Source Type: research

Glycomic Profiles of Ferret Respiratory Tissues [Glycobiology and Extracellular Matrices]
The initial recognition between influenza virus and the host cell is mediated by interactions between the viral surface protein hemagglutinin and sialic acid-terminated glycoconjugates on the host cell surface. The sialic acid residues can be linked to the adjacent monosaccharide by α2–3- or α2–6-type glycosidic bonds. It is this linkage difference that primarily defines the species barrier of the influenza virus infection with α2–3 binding being associated with avian influenza viruses and α2–6 binding being associated with human strains. The ferret has been extensively used as an animal model to study the tran...
Source: Journal of Biological Chemistry - October 9, 2014 Category: Chemistry Authors: Jia, N., Barclay, W. S., Roberts, K., Yen, H.-L., Chan, R. W. Y., Lam, A. K. Y., Air, G., Peiris, J. S. M., Dell, A., Nicholls, J. M., Haslam, S. M. Tags: Glycobiology and Extracellular Matrices Source Type: research

Antibiotics for bronchiolitis in children under two years of age.
CONCLUSIONS: This review did not find sufficient evidence to support the use of antibiotics for bronchiolitis, although research may be justified to identify a subgroup of patients who may benefit from antibiotics. Further research may be better focused on determining the reasons that clinicians use antibiotics so readily for bronchiolitis, how to reduce their use and how to reduce clinician anxiety about not using antibiotics. PMID: 25300167 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 9, 2014 Category: Journals (General) Authors: Farley R, Spurling GK, Eriksson L, Del Mar CB Tags: Cochrane Database Syst Rev Source Type: research

Antibiotics for community-acquired pneumonia in adult outpatients.
CONCLUSIONS: Available evidence from recent RCTs is insufficient to make new evidence-based recommendations for the choice of antibiotic to be used for the treatment of CAP in outpatient settings. Pooling of study data was limited by the very low number of studies assessing the same antibiotic pairs. Individual study results do not reveal significant differences in efficacy between various antibiotics and antibiotic groups. However, two studies did find significantly more adverse events with use of cethromycin as compared to clarithromycin and nemonoxacin when compared to levofloxacin. Multi-drug comparisons using similar ...
Source: Cochrane Database of Systematic Reviews - October 9, 2014 Category: Journals (General) Authors: Pakhale S, Mulpuru S, Verheij TJ, Kochen MM, Rohde GG, Bjerre LM Tags: Cochrane Database Syst Rev Source Type: research

Four-dimensional, multiphase, steady-state imaging with contrast enhancement (MUSIC) in the heart: A feasibility study in children.
CONCLUSION: The 4D MUSIC technique may represent a new paradigm in MR evaluation of cardiovascular anatomy and function in children with complex congenital heart disease. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. PMID: 25302932 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - October 9, 2014 Category: Radiology Authors: Han F, Rapacchi S, Khan S, Ayad I, Salusky I, Gabriel S, Plotnik A, Paul Finn J, Hu P Tags: Magn Reson Med Source Type: research

Organic Changes in the Central Nervous System in Children on Chronic Inhaled Corticosteroid Therapy.
In conclusion, patients receiving chronic inhaled corticosteroids had small subcortical hyperintense foci and features of mild supratentorial cortical atrophy. These findings suggest that ICS exposure may be associated with the development of organic changes in CNS. Further studies are needed to detail the extent of brain ICS-induced changes in children on chronic inhalative corticosteroid therapy as well as delayed impact of these changes on psychomotor functioning in adulthood. PMID: 25298261 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - October 9, 2014 Category: Epidemiology Authors: Michalczuk M, Sybilski AJ, Piliszek A, Walecki J Tags: Adv Exp Med Biol Source Type: research

Virgibacillus oceani sp. nov. isolated from the Western Pacific.
Abstract A Gram-positive, moderately halophilic, motile, aerobic, endospore-forming, rod-shaped bacterium, strain MY11 (T), was isolated from a sediment sample collected from the Western Pacific. This isolate grew in the presence of 0.5-18 % (w/v) NaCl and at pH 6.0-10.0 and 15-45 °C; optimum growth was observed with 3.5 % (w/v) NaCl and at pH8.0-9.0 and 35-37 °C. Strain MY11(T) had MK-7 as the predominant respiratory quinone and anteiso-C15:0 and anteiso-C17:0 as major fatty acids. Major polar lipids were diphosphatidylglycerol and phosphatidylglycerol. The DNA G+C content was 34.2 mol%. Phylogenetic analysis ba...
Source: International Journal of Systematic and Evolutionary Microbiology - October 9, 2014 Category: Microbiology Authors: Yin X, Yang Y, Wang S, Zhang G Tags: Int J Syst Evol Microbiol Source Type: research

Spongiibacterium pacificum sp. nov., isolated from seawater of South Pacific Gyre and emended description of the genus Spongiibacterium.
Abstract A Gram-stain-negative, strictly aerobic, non-flagellated, non-gliding, oxidase-positive and rod shaped yellow-pigmented bacterium, designated strain SW169T, was isolated from surface seawater sample collected from the South Pacific Gyre (27°55' S 123°10' W) during the Integrated Ocean Drilling Program (IODP) Expedition 329. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain SW169T belonged to the genus Spongiibacterium and showed the highest 16S rRNA gene sequence similarity with Spongiibacterium flavum A11T (95.9%). It showed 93.2-94.8% 16S rRNA gene sequence similarity with re...
Source: International Journal of Systematic and Evolutionary Microbiology - October 9, 2014 Category: Microbiology Authors: Gao X, Zhang Z, Dai X, Zhang XH Tags: Int J Syst Evol Microbiol Source Type: research

ECMO support for right main bronchial disruption in multiple trauma patient with brain injury-a case report and literature review.
Abstract Extracorporeal membrane oxygenation (ECMO) may offer life-saving treatment in severe pulmonary contusion or acute respiratory distress syndrome when conventional treatments have failed. However, because of the bleeding risk of systemic anticoagulation, ECMO should be performed only as a last resort in multiple trauma victims. Here, we report ECMO as a bridge for right main bronchus reconstruction and recovery of traumatic wet lung in a 31-year-old male multi-trauma patient with right main bronchial disruption, bilateral pulmonary contusion, cerebral contusion and long bone fracture. The patient was dischar...
Source: Perfusion - October 9, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Zhou R, Liu B, Lin K, Wang R, Qin Z, Liao R, Qiu Y Tags: Perfusion Source Type: research

Current concept of transcatheter closure of atrial septal defect in adults.
Abstract After the introduction of catheter intervention for atrial septal defect (ASD) in the pediatric population, therapeutic advantages of this less invasive procedure were focused on adult through geriatric populations. The most valuable clinical benefits of this procedure are the significant improvement of symptoms and daily activities, which result from the closure of left to right shunt without thoracotomy and cardiopulmonary bypass surgery. These benefits contribute to increase the number of adult patients of this condition who have hesitated over surgical closure. In terms of technical point of view for c...
Source: Journal of Cardiology - October 9, 2014 Category: Cardiology Authors: Akagi T Tags: J Cardiol Source Type: research

Frequency of viral etiology in symptomatic adult upper respiratory tract infections.
CONCLUSION: Results presented in this report suggest that respiratory viral infections are largely under diagnosed in immunocompetent adults. Although the majority of young adult infections are not life-threatening they may impose a significant burden, especially in developing countries since these individuals represent a large fraction of the working force. PMID: 25307684 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - October 9, 2014 Category: Infectious Diseases Authors: da Silva RC, da Silva Mendes G, Rojas MA, Amorim AR, Couceiro JN, Lupi O, Elabras J, Pires G, Valle S, Santos N Tags: Braz J Infect Dis Source Type: research

CT findings of probable UIP have a high predictive value for histologic UIP.
Conclusions:Probable CT UIP is associated with a higher rate of histologic UIP than indeterminate CT UIP suggesting that they are distinct groups and should not be combined into a single CT category as currently recommended by guidelines. CT and microscopic honeycombing may be dissimilar entities. The T allele at rs35705950 predicts a UIP diagnosis by both chest CT and histology. Background: The current UIP/IPF CT classification system excludes probable UIP as a diagnostic category. We sought to determine the predictive effect of probable CT UIP on histology, and to determine the effect of the promoter polymorphism in ...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Chung JH, Chawla A, Peljto AL, Cool C, Groshong SD, Talbert JL, McKean D, Brown KK, Fingerlin TE, Schwarz MI, Schwartz DA, Lynch DA Tags: Chest Source Type: research

Non-Invasive Positive Pressure Ventilation Following Esophagectomy: Safety Demonstrated in a Pig Model.
Conclusions:Our pig model suggests that an esophagectomy anastomosis can tolerate a considerably higher pressure than is transmitted to the esophagus during NPPV. NPPV may be a safe alternative to ET after esophagectomy. Background: Respiratory complications occur in 20-65% of esophagectomy patients. While non-invasive positive pressure ventilation (NPPV) is associated with fewer complications than endotracheal intubation (ET), it is relatively contraindicated after esophagectomy due to potential injury to the anastomosis. We created an ex vivo and in vivo pig model to determine the pressure tolerance of an esophagecto...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Raman V, MacGlaflin CE, Erkmen CP Tags: Chest Source Type: research

Pre-Intubation application of oral chlorhexidine does not provide additional benefit in prevention of early onset ventilator-associated pneumonia.
ConclusionsAlthough it is feasible to deliver CHX prior to intubation (including emergent or urgent intubation), the results suggest that pre-intubation CHX may be inconsequential when the ventilator bundle, including daily oral CHX, is in place. During the pre-intubation period, providers should focus their attention on other critical activities.Clinical Trial NCT00893763. Introduction: Daily application of oral chlorhexidine gluconate (CHX) following intubation to reduce risk of ventilator-associated pneumonia (VAP) is now standard of care in many intensive care units. This randomized ...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Munro CL, Grap MJ, Sessler CN, Elswick RK, Mangar D, Karlnoski-Everall R, Cairns P Tags: Chest Source Type: research

Prognostic Accuracy of Clinical Prediction Rules for Early Post-Pulmonary Embolism All-Cause Mortality: A Bivariate Meta-Analysis.
Conclusions:Numerous CPRs for prognosticating early mortality in aPE patients are available, but not all demonstrate the high sensitivity needed to reassure clinicians. Background: Studies suggest outpatient treatment or early discharge of acute pulmonary embolism (aPE) is reasonable for those deemed to be at low-risk of early mortality. We sought to determine clinical prediction rule (CPR) accuracy for identifying aPE patients at low-risk for mortality. Methods: We performed a literature search of Medline and Embase from January 2000-March 2014, along with a manual search of references. We included studies derivin...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Kohn CG, Mearns EL, Parker MW, Hernandez AV, Coleman CI Tags: Chest Source Type: research

Ventilation-perfusion distribution abnormalities in morbidly obese subjects before and after bariatric surgery.
CONCLUSIONS.Morbid obesity is associated with mild-to-moderate shunt and VA/Q imbalance. These abnormalities are reduced after BS. BACKGROUND.: Obesity is a global and growing public health problem. Bariatric surgery (BS) is indicated in patients with morbid obesity. The effects of morbid obesity and BS upon ventilation-perfusion (VA/Q) ratio distributions using the multiple inert gas elimination technique have never been explored before. METHODS.: We compared respiratory and inert gas (VA/Q ratio distributions) pulmonary gas exchange, both breathing ambient air and 100% oxygen, in 19 morbidly obese women (body mas...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Rivas E, Arismendi E, Agustí A, Sanchez M, Delgado S, Gistau C, Wagner PD, Rodriguez-Roisin R Tags: Chest Source Type: research

Bardet Biedl Syndrome: Motile Ciliary Phenotype.
In conclusion motile ciliary structure and function is essentially normal in patients with BBS. Cilia line the surface of the respiratory tract and beat in a coordinated wave to protect the lungs against infection. Bardet Biedl Syndrome (BBS) is rare condition attributed to cilia dysfunction. Murine models of BBS suggest a respiratory phenotype, however, no reports have studied the translation of these findings in patients. We assessed clinical symptoms of motile cilia dysfunction and histology of ciliated respiratory epithelium in patients with BBS. We report an increased prevalence of neonatal respiratory dis...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Shoemark A, Dixon M, Beales P, Hogg C Tags: Chest Source Type: research

Development of a novel multilayered presentation format for clinical practice guidelines.
Conclusion:We have developed an electronic multilayered CPG format that enhances the usability of CPGs for front-line clinicians. We have implemented the format in electronic guideline tools which guideline organizations can now use when authoring and publishing their guidelines. Background: Bridging the gap between clinical research and everyday healthcare practice requires effective communication strategies. To address current shortcomings in conveying practice recommendations and supporting evidence, we are creating and testing presentation formats for clinical practice guidelines (CPGs). Methods: We carried out...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Kristiansen A, Brandt L, Alonso-Coello P, Agoritsas T, Akl EA, Conboy T, Elbarbary M, Ferwana M, Medani W, Murad MH, Rigau D, Rosenbaum S, Spencer FA, Treweek S, Guyatt G, Vandvik PO Tags: Chest Source Type: research

Choosing Wisely in Critical Care Maximizing Value in the Intensive Care Unit.
Abstract Abstract: Overuse of medical tests and treatments wastes health care resources and leads to unnecessary complications, while underuse results in delayed or missed diagnoses and treatment opportunities. Such problems are well recognized and there have been multiple attempts to correct inappropriate diagnostic testing and treatment over the past several decades. However, sustainable solutions have proven to be elusive. PMID: 25317583 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Angus DC, Deutschman CS, Hall JB, Wilson KC, Munro CL, Hill NS Tags: Chest Source Type: research

Pulmonary arterial hypertension in the southern hemisphere: results from a registry of incident Brazilian cases.
Conclusions:The distribution of PAH etiologies and the baseline characteristics in our registry clearly differ from the previously published European and USA-based registries. These differences highlight the importance of regional registries and also raise questions regarding the need to better account for such differences in future clinical trials. Background: Pulmonary arterial hypertension (PAH) is a rare and ultimately fatal disorder of the pulmonary vasculature. There is increasing interest in the worldwide characteristics of PAH patients, although data coming from the southern hemisphere remain scarce. The object...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Alves JL, Gavilanes F, Jardim C, Fernandes CJ, Morinaga LT, Dias B, Hoette S, Humbert M, Souza R Tags: Chest Source Type: research

Childhood consequences of maternal obesity and excessive weight gain during pregnancy
Abstract Obesity is a major public health concern. In western countries, the prevalence of obesity in pregnant women has strongly increased, with reported prevalence rates reaching 30%. Also, up to 40% of women gain an excessive amount of weight during pregnancy. Recent observational studies and meta‐analyses strongly suggest long‐term impact of maternal obesity and excessive weight gain during pregnancy on adiposity, cardiovascular and respiratory related health outcomes in their children. These observations suggest that maternal adiposity during pregnancy may program common health problems in the offspring. Currently...
Source: Acta Obstetricia et Gynecologica Scandinavica - October 9, 2014 Category: OBGYN Authors: Romy Gaillard, Janine F. Felix, Liesbeth Duijts, Vincent W.V. Jaddoe Tags: Commentary Source Type: research

Trichomonas vaginalis Induces Cytopathic Effect on Human Lung Alveolar Basal Carcinoma Epithelial Cell Line A549.
Abstract Trichomonas vaginalis, the causative agent of trichomoniasis is generally known to inhabit the genitourinary tract. However, several case reports with supporting molecular and immunological identifications have documented its occurrence in the respiratory tract of neonates and adults. In addition, the reports have documented that its occurrence is associated with respiratory failures. The medical significance or consequence of this association is unclear. Thus, to establish the possible outcome from the interaction of T. vaginalis with lung cells, the cytopathic effects of the parasites were evaluated usin...
Source: Experimental Parasitology - October 9, 2014 Category: Parasitology Authors: Salvador-Membreve DM, Jacinto SD, Rivera WL Tags: Exp Parasitol Source Type: research

Detection of a novel avian influenza A (H7N9) virus in humans by multiplex one-step real-time RT-PCR assay
Conclusions: These results demonstrate that the multiplex assay detected the novel avian H7N9 virus with high specificity and sensitivity, which is essential for the early diagnosis and treatment of infected patients. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 8, 2014 Category: Infectious Diseases Authors: Jian FanDavid CuiSiuying LauGuoliang XieXichao GuoShufa ZhengXiaofeng HuangShigui YangXianzhi YangZhaoxia HuoFei YuJianzhou LouLi TianXuefen LiYuejiao DongQiaoyun ZhuYu Chen Source Type: research

Pathogenesis of Middle East respiratory syndrome coronavirus
This article reviews the clinical and pathological available on MERS and compares it to SARS. Most importantly, chest radiographs and imaging results of patients with MERS show features that resemble the findings of organizing pneumonia, different from the lesions in SARS patients, which show fibrocellular intra‐alveolar organization with a bronchiolitis obliterans organizing pneumonia‐like pattern. These findings are in line with differences in the induction of cytopathological changes, induction of host gene responses and sensitivity to the antiviral effect of interferons in vitro when comparing both MERS‐CoV and S...
Source: The Journal of Pathology - October 8, 2014 Category: Pathology Authors: Judith M.A. van den Brand, Saskia L. Smits, Bart L. Haagmans Tags: Invited Review Source Type: research

Exchange transfusion can be life-saving in severe propanil poisoning: a case report
Conclusion: Propanil has potential to produce severe life threatening clinical manifestations, despite categorization as a herbicide with low toxicity. In cases of severe poisoning, exchange transfusion may be life saving. Since methylene blue, intensive care and exchange transfusion facilities are also not readily available in local hospitals, which frequently encounter cases of severe Propanil poisoning, early transfer of patients to tertiary care hospitals should be considered. Exchange transfusion may be helpful even in late stages in patients with severe poisoning. (Source: BMC Research Notes)
Source: BMC Research Notes - October 8, 2014 Category: Research Authors: Priyanga RanasingheShani DilrukshiInoshi AtukoralaPrasad KatulandaAriaranee Gnanathasan Source Type: research

Impact of ozone exposure on the response to glucocorticoid in a mouse model of asthma: involvements of p38 MAPK and MKP-1
Conclusions: The glucocorticoids insensitivity elicited by ozone exposure on current asthma model may involve the enhanced phosphorylation of p38 MAPK and disturbed expression of MKP-1. (Source: Respiratory Research)
Source: Respiratory Research - October 8, 2014 Category: Respiratory Medicine Authors: Aihua BaoFeng LiMin ZhangYuqing ChenPengyu ZhangXin Zhou Source Type: research

Up-regulation of hexokinase1 in the right ventricle of monocrotaline induced pulmonary hypertension
Conclusions: There was an increase in the protein and mRNA expression of hexokinase-1 (HK1) three and four weeks after the injection of monocrotaline in the right ventricle, intervention of HK1 may be amenable to therapeutic intervention. (Source: Respiratory Research)
Source: Respiratory Research - October 8, 2014 Category: Respiratory Medicine Authors: Wei-hua ZhangMei-hong QiuXiao-jian WangKai SunYang ZhengZhi-cheng Jing Source Type: research