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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Children's exposure to second hand smoke at home: A cross-sectional study in Portugal
This study describes Portuguese children's exposure to SHS at home (total and by Portuguese main regions). In 2010/2011, a questionnaire was applied to a sample of Portuguese children in the 4th grade (N =3187, mean age 9.05±0.7 years, 51.1% male). Descriptive analysis, chi-square tests and crude odds ratios were performed. Of the participants, 62.9% of those with smoking parents and 19.2% of those with non-smoking parents were exposed to SHS at their home. Parental smoking varied significantly among regions and was significantly associated with children's exposure to SHS at home. Children's exposure to SHS at home was hi...
Source: Revista Portuguesa de Pneumologia - January 20, 2015 Category: Respiratory Medicine Source Type: research

Evaluation of clinical presentation and outcome of patients with respiratory bronchiolitis-associated interstitial lung disease
Publication date: Available online 20 January 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): M. Vaz , N. Melo , P.C. Mota , R. Cunha , J.M. Pereira (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - January 20, 2015 Category: Respiratory Medicine Source Type: research

Melatonin attenuates lung injury in a hind limb ischemia–reperfusion rat model
Conclusions These findings suggest that melatonin has preventive effects in lung tissue injury after transient femoral artery occlusion. (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - January 20, 2015 Category: Respiratory Medicine Source Type: research

Long-term ventilation in children: Ten years later
Conclusions HMV programs provide necessary and safe assistance for children with severe chronic respiratory failure. As shown in our series, it is possible to be kept on this respiratory support modality for long periods with good compliance and a small number of hospitalizations. (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - January 20, 2015 Category: Respiratory Medicine Source Type: research

Drug related toxicity in lung transplant recipients
Publication date: Available online 20 January 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): M. van Zeller , C. Damas (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - January 20, 2015 Category: Respiratory Medicine Source Type: research

Clinical Manifestations of Non-O1 Vibrio cholerae Infections
Conclusions Non-O1 V. cholera infections can cause protean disease, especially in patients with risk factors and during warm-weather months. The overall mortality of 83 patients with non-O1 V. cholera infections was only 7.2%; however, this value varied among different types of infection. (Source: PLoS One)
Source: PLoS One - January 20, 2015 Category: Biomedical Science Authors: Yen-Ting Chen et al. Source Type: research

The effects of sex and neonatal stress on pituitary adenylate cyclase‐activating peptide expression
New Findings What is the central question of this study? Does sex or neonatal stress affect the expression of pituitary adenylate cyclase‐activating peptide or its receptors? What is the main finding and its importance? Neonatal–maternal separation stress has little long‐lasting effect on the expression of pituitary adenylate cyclase‐activating peptide or its receptors, but sex differences exist in these genes between males and females at baseline. Sex differences in classic stress hormones have been studied in depth, but pituitary adenylate cyclase‐activating peptide (PACAP), recently identified as playing a c...
Source: Experimental Physiology - January 20, 2015 Category: Physiology Authors: E. V. Mosca, J. P. Rousseau, R. Gulemetova, R. Kinkead, R. J. A. Wilson Tags: Research Paper Source Type: research

Selection for high and low oxygen consumption altered hepatic mitochondrial energy efficiency in mice
Abstract Selection for high (H) and low (L) oxygen consumption (OC) as an indirect estimation of maintenance energy requirement was determined. Feed intake and body weight were measured and feed conversion ratio (FCR) of 4–8‐week‐old mice was calculated. Respiratory activity of hepatic mitochondria was measured at 12 weeks. Total feed intake (H: 103.74 g, L: 97.92 g, P < 0.01), daily feed intake (H: 3.70 g/day, L: 3.50 g/day, P < 0.01) and FCR (H: 18.79, L: 15.50, P < 0.01) were significantly different between lines. The line by sex interaction was significant for FCR. No line differences...
Source: Animal Science Journal - January 20, 2015 Category: Zoology Authors: Yu Hong, Astrid Ardiyanti, Motoi Kikusato, Tomoyuki Shimazu, Masaaki Toyomizu, Keiichi Suzuki Tags: Original Article Source Type: research

Diagnosing paediatric myocarditis: what really matters
Conclusions A cut-off risk score of 3, though not yet validated, may be potentially useful in future to trigger further investigations for children with suspected myocarditis. It allows for the appropriate use of resources, while minimising on misdiagnosis. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - January 20, 2015 Category: Emergency Medicine Authors: Chong, S.-L., Bautista, D., Ang, A. S.-Y. Tags: Cardiomyopathy, Drugs: cardiovascular system, Radiology, Clinical diagnostic tests, Radiology (diagnostics) Original article Source Type: research

Surgical treatment of a case of adult epiglottic laryngomalacia
Discussion Excessive resection of the epiglottis may lead to false passage; insufficient resection risks being ineffective. V-shaped partial epiglottectomy minimizes risk of false passage while ensuring permanent respiratory airflow via the epiglottic V during epiglottic movement. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - January 20, 2015 Category: ENT & OMF Source Type: research

Rates of Noncommunicable Diseases Increasing in Developing Countries
Cancer, cardiovascular disease, chronic respiratory illnesses, and diabetes are on the rise in developing countries and are affecting people at younger ages and having worse outcomes than in wealthier countries, according to a report by a task force from the Council on Foreign Relations, “The Emerging Global Health Crisis: Noncommunicable Diseases in Low- and Middle-Income Countries” ( (Source: JAMA)
Source: JAMA - January 20, 2015 Category: Journals (General) Source Type: research

Protocolized Sedation vs Usual Care in Pediatric Patients Mechanically Ventilated for Acute Respiratory Failure A Randomized Clinical Trial
ImportanceProtocolized sedation improves clinical outcomes in critically ill adults, but its effect in children is unknown.ObjectiveTo determine whether critically ill children managed with a nurse-implemented, goal-directed sedation protocol experience fewer days of mechanical ventilation than patients receiving usual care.Design, Setting, and ParticipantsCluster randomized trial conducted in 31 US pediatric intensive care units (PICUs). A total of 2449 children (mean age, 4.7 years; range, 2 weeks to 17 years) mechanically ventilated for acute respiratory failure were enrolled in 2009-2013 and followed up until 72 hours ...
Source: JAMA - Journal of the American Medical Association - January 20, 2015 Category: Journals (General) Source Type: research

Determination of left atrium volume by fast anatomical mapping and intracardiac echocardiography. The contribution of respiratory gating
Conclusions In the absence of respiratory gating, LA volumes determined by FAM are larger than those obtained with ICE. In contrast, with the addition of respiratory gating, both FAM and ICE provide similar real-time LA volumes. (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - January 20, 2015 Category: Cardiology Source Type: research

Nasal Eosinophilic Angiocentric Fibrosis with Orbital Extension
We report a case of sinonasal EAF with orbital extension that presented with left nasolacrimal duct obstruction. A 35-year-old man presented with left epiphora, proptosis, anterolateral globe displacement and nasal obstruction. Endoscopic sinus examination showed a firm, gritty, creamy, yellow, fibrous, adherent mass of maxillary sinus. Diagnosis was established with histopathological examination of excisional biopsy of the lesion. Although EAF is very rare, it should be considered in the differential diagnosis of lesions of upper airway tract, particularly the nasal cavity. Biopsy is necessary for diagnosis and treatment ...
Source: Head and Neck Pathology - January 20, 2015 Category: Pathology Source Type: research

Leptin and leptin receptor gene polymorphisms in obstructive sleep apnea: a HuGE review and meta-analysis
Conclusions Our study suggested that leptin and LEPR polymorphisms had no association with OSA risk in all examined patients, whereas there was an association between Gln233Arg polymorphism and OSA risk in Europeans. (Source: Sleep and Breathing)
Source: Sleep and Breathing - January 20, 2015 Category: Respiratory Medicine Source Type: research

Characterization of obstructive sleep apnea in patients with insomnia across gender and age
Conclusion Similar to the gender differences reported in general population studies, men had a much greater OSA prevalence than women prior to 55 years of age, but not at ages greater than 55 years. (Source: Sleep and Breathing)
Source: Sleep and Breathing - January 20, 2015 Category: Respiratory Medicine Source Type: research

Autophagy activation protects from mitochondrial dysfunction in human chondrocytes
Conclusion: Our data highlight the role of autophagy as a critical protective mechanism against mitochondrial dysfunction. Pharmacological interventions that enhance autophagy may have chondroprotective activity in cartilage degenerative processes such as OA. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 20, 2015 Category: Rheumatology Authors: Paloma López de Figueroa, Martin Lotz, Francisco J. Blanco, Beatriz Caramés Tags: Full Length Source Type: research

Polycyclic aromatic hydrocarbons and childhood asthma
Abstract Asthma is the most common chronic illness in children living in developed countries and the leading cause of childhood hospitalization and school absenteeism. Prevalence rates of asthma are increasing and show disparities across gender, geographic regions, and ethnic/racial groups. Common risk factors for developing childhood asthma include exposure to tobacco smoke, previous allergic reactions, a family history of asthma, allergic rhinitis or eczema, living in an urban environment, obesity and lack of physical exercise, severe lower respiratory tract infections, and male gender. Asthma exacerbation in ch...
Source: European Journal of Epidemiology - January 20, 2015 Category: Epidemiology Source Type: research

Non-allergenic factors from pollen modulate T helper cell instructing notch ligands on dendritic cells
Conclusions Pollen derived, non-allergenic factors reduce the dendritic cell’s expression of Th1 instructing Delta-like notch ligands and of MyD88, thereby promoting Th2 skewing of T helper cell responses. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 20, 2015 Category: Allergy & Immunology Source Type: research

Topographical Diversity of the Respiratory Tract Mycobiome and Alteration in HIV and Lung Disease.
Conclusions: This study systematically examined the respiratory tract mycobiome in a relatively large group. By identifying Pneumocystis and other fungal species as overrepresented in the lung in HIV and in COPD, it is the first to determine alterations in fungal communities associated with lung dysfunction and/or HIV, highlighting clinical relevance of these findings. Clinical trial registration available at, ID NCT00870857. PMID: 25603113 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 20, 2015 Category: Respiratory Medicine Authors: Cui L, Lucht L, Tipton L, Rogers MB, Fitch A, Kessinger C, Camp D, Kingsley L, Leo N, Greenblatt RM, Fong S, Stone S, Dermand J, Kleerup E, Huang L, Morris A, Ghedin E Tags: Am J Respir Crit Care Med Source Type: research

Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)
Abstract Background Since the identification of the first case of infection with the Middle East respiratory syndrome corona virus (MERS-CoV) in Saudi Arabia in June 2012, the number of laboratory-confirmed cases has exceeded 941 cases globally, of which 347 died. The disease presents as severe respiratory infection often with shock, acute kidney injury, and coagulopathy. Recently, we observed three cases who presented with neurologic symptoms. These are so far the first reported cases of neurologic injury associated with MERS-CoV infection. Methods Data...
Source: Infection - January 20, 2015 Category: Infectious Diseases Source Type: research

Subcutaneous Emphysema in Acute Asthma: A Cause for Concern?
Abstract Pneumomediastinum has been described in patients with asthma. In this case report, we describe a young patient who presented to our medical assessment unit with an asthma exacerbation and progressive dyspnea. The patient developed pneumomediastinum, a rare complication of an asthma exacerbation. Pneumomediastinum is usually characterized by chest pain, dyspnea, and neck swelling caused by subcutaneous emphysema. Although the condition is usually benign and treatment is primarily supportive, surgical intervention may be needed if the patient develops hemodynamic compromise or respiratory failure through mec...
Source: Respiratory Care - January 20, 2015 Category: Respiratory Medicine Authors: Mitchell PD, King TJ, O'Shea DB Tags: Respir Care Source Type: research

Additional Evidence for the Long-Term Benefits of Pulmonary Rehabilitation.
CONCLUSIONS: This study demonstrated the ability of one pulmonary rehabilitation program to accurately monitor extended long-term follow-up after pulmonary rehabilitation. Implementing this long-term monitoring methodology consistently in pulmonary rehabilitation programs could contribute to evaluation of the comparative effectiveness of various treatment options. PMID: 25605958 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 20, 2015 Category: Respiratory Medicine Authors: Donesky D, Citron TL, Hilling L, Cayou C, Milic MM Tags: Respir Care Source Type: research

Influence of Different Interfaces on Synchrony During Pressure Support Ventilation in a Pediatric Setting: A Bench Study.
CONCLUSIONS: The choice of the interface can influence patient-ventilator synchrony in a pediatric model breathing at increased f, thus making it more difficult to set the ventilator, particularly during noninvasive ventilation. The helmet demonstrated the worst interaction, suggesting that the face mask should be considered as the first choice for delivering noninvasive ventilation in a pediatric model. PMID: 25605957 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 20, 2015 Category: Respiratory Medicine Authors: Conti G, Gregoretti C, Spinazzola G, Festa O, Ferrone G, Cipriani F, Rossi M, Piastra M, Costa R Tags: Respir Care Source Type: research

Ultrastructural analysis of five patients with total sperm immotility.
In conclusion, we present three cases with DFS associated with total sperm immotility, abnormal mitochondria, and absence of the annulus, central pair complex and radial spokes, of which one had in addition absence of dynein arms and nexin bridges. We also describe a patient, with total sperm immotility and a different presentation of DFS, as the annulus was present and the dysplastic fibrous sheath was restricted to the principal piece. These findings thus confirm the heterogeneity of the DFS condition. The changes observed in the patient with situs-inversus also further support previous observations. PMID: 25601002 [...
Source: Zygote - January 20, 2015 Category: Reproduction Medicine Authors: Sousa M, Oliveira E, Alves Â, Gouveia M, Figueiredo H, Ferraz L, Barros A, Sá R Tags: Zygote Source Type: research

Photoinduction of cyclosis-mediated interactions between distant chloroplasts.
Abstract Communications between chloroplasts and other organelles based on the exchange of metabolites, including redox active substances, are recognized as a part of intracellular regulation, chlororespiration, and defense against oxidative stress. Similar communications may operate between spatially distant chloroplasts in large cells where photosynthetic and respiratory activities are distributed unevenly under fluctuating patterned illumination. Microfluorometry of chlorophyll fluorescence in vivo in internodal cells of the alga Chara corallina revealed that a 30-s pulse of localized light induces a transient i...
Source: Biochimica et Biophysica Acta - January 20, 2015 Category: Biochemistry Authors: Bulychev AA, Komarova AV Tags: Biochim Biophys Acta Source Type: research

Stigmatellin Probes the Electrostatic Potential in the QB Site of the Photosynthetic Reaction Center.
Abstract The electrostatic potential in the secondary quinone (QB) binding site of the reaction center (RC) of the photosynthetic bacterium Rhodobacter sphaeroides determines the rate and free energy change (driving force) of electron transfer to QB. It is controlled by the ionization states of residues in a strongly interacting cluster around the QB site. Reduction of the QB induces change of the ionization states of residues and binding of protons from the bulk. Stigmatellin, an inhibitor of the mitochondrial and photosynthetic respiratory chain, has been proven to be a unique voltage probe of the QB binding pock...
Source: Biophysical Journal - January 20, 2015 Category: Physics Authors: Gerencsér L, Boros B, Derrien V, Hanson DK, Wraight CA, Sebban P, Maróti P Tags: Biophys J Source Type: research

Sphingomonas gei sp. nov., isolated from roots of Geum aleppicum.
Abstract A yellow-pigmented bacterium, designated strain ZFGT-11T, was isolated from roots of Geum aleppicum Jacq. collected from Taibai Mountain in Shaanxi Province, north-west China, and was subjected to a taxonomic study by using a polyphasic approach. Cells of strain ZFGT-11T were Gram-staining-negative, strictly aerobic rods that were surrounded by a thick capsule and motile by means of a single polar flagellum. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain ZFGT-11T was a member of the genus Sphingomonas and was closely related to Sphingomonas naasensis KACC 16534T (97.6 % similarit...
Source: International Journal of Systematic and Evolutionary Microbiology - January 20, 2015 Category: Microbiology Authors: Zhu L, Si M, Li C, Xin K, Chen C, Shi X, Huang R, Zhao L, Shen X, Zhang L Tags: Int J Syst Evol Microbiol Source Type: research

Ichthyenterobacterium magnum gen. nov., sp. nov., a novel member of the family Flavobacteriaceae isolated from olive flounder (Paralichthys olivaceus).
Abstract A novel marine bacterium isolated from intestine of cultured flounder (Paralichthys olivaceus) was studied by using a polyphasic taxonomic approach. The isolate was Gram-stain-negative, pleomorphic, aerobic, yellow-pigmented, oxidase- and catalase-negative. Phylogenetic analysis of 16S rRNA gene sequences indicated that isolate Th6T formed a distinct branch within the family Flavobacteriaceae and showed 96.6 % similarity to its closest relative, Bizionia hallyeonsis T-y7T. The DNA G+C content was 29 mol%. The major respiratory quinone was MK-6. The predominant fatty acids were iso-C15 : 1 G, iso-C15 : 0 , ...
Source: International Journal of Systematic and Evolutionary Microbiology - January 20, 2015 Category: Microbiology Authors: Shakeela Q, Shehzad A, Tang K, Zhang Y, Zhang XH Tags: Int J Syst Evol Microbiol Source Type: research

Hyunsoonleella pacifica sp. nov., isolated from seawater of South Pacific Gyre.
Abstract A Gram-stain-negative, strictly aerobic, non-flagellated, non-gliding, oxidase- and catalase-positive and rod shaped yellow-pigmented bacterium, designated strain SW033T was isolated from surface seawater sample collected from the South Pacific Gyre (26°29' S, 137°56' W) during the Integrated Ocean Drilling Program (IODP) Expedition 329. Phylogenetic analysis based on 16S rRNA gene sequences indicated that the strain SW033T belonged to the genus Hyunsoonleella and showed the highest 16S rRNA gene sequence similarity with Hyunsoonleella jejuensis CNU004T (96.8%). It showed 94.7-95.8% 16S rRNA gene sequenc...
Source: International Journal of Systematic and Evolutionary Microbiology - January 20, 2015 Category: Microbiology Authors: Gao X, Zhang Z, Dai X, Zhang XH Tags: Int J Syst Evol Microbiol Source Type: research

Full genome sequence analysis of a wild, non-MLV-related type 2 Hungarian PRRSV variant isolated in Europe.
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) is a widespread pathogen of pigs causing significant economic losses to the swine industry. The expanding diversity of PRRSV strains makes the diagnosis, control and eradication of the disease more and more difficult. In the present study, the authors report the full genome sequencing of a Type 2 PRRSV strain isolated from piglet carcasses in Hungary. Next generation sequencing was used to determine the complete genome sequence of the isolate (PRRSV-2/Hungary/102/2012). Recombination analysis performed with the available full-length genome sequenc...
Source: Virus Research - January 20, 2015 Category: Virology Authors: Balka G, Wang X, Olasz F, Bálint Á, Kiss I, Bányai K, Rusvai M, Stadejek T, Marthaler D, Murtaugh MP, Zádori Z Tags: Virus Res Source Type: research

Programming and Regulation of Metabolic Homeostasis.
Abstract ABSTRACT Evidence is presented that the rate and equilibrium constants in mitochondrial oxidative phosphorylation set and maintain metabolic homeostasis in eukaryotic cells. These internal constants determine the energy state ([ATP]/[ADP][Pi]), and the energy state maintains homeostasis through a bidirectional sensory/signaling control network that reaches every aspect of cellular metabolism. The energy state is maintained with high precision (to about 1 part in 10(10)) and the control system can respond to transient changes in energy demand (ATP utilization) of more than 100 times the resting rate. Epigen...
Source: American Journal of Physiology. Endocrinology and Metabolism - January 20, 2015 Category: Physiology Authors: Wilson DF Tags: Am J Physiol Endocrinol Metab Source Type: research

Mitochondrial Reprogramming Induced by CaMKIIδ Mediates Hypertrophy Decompensation.
Conclusions: Mitochondrial gene reprogramming induced by CaMKIIδ emerges as an important mechanism contributing to mitotoxicity in decompensating hypertrophy. PMID: 25605649 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - January 20, 2015 Category: Cardiology Authors: Westenbrink BD, Ling H, Miyamoto S, Divakaruni A, Gray CB, Zambon AC, Dalton ND, Peterson K, Gu Y, Matkovich SJ, Murphy AN, Dorn GW, Heller Brown J Tags: Circ Res Source Type: research

Echinocandin Use in Hospitalized Patients: A Multi-institutional Study.
CONCLUSIONS:: This study provides useful benchmark data on antifungal use and indications for use that could be used for antifungal stewardship program comparisons. PMID: 25607510 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - January 20, 2015 Category: Journals (General) Authors: Garey KW, Aitken SL, Dima-Ala A, Beyda ND, Kuper K, Xie Y, Koo HL Tags: Am J Med Sci Source Type: research

Prevention of microbial communities: novel approaches based natural products.
Abstract Firmly attached to different living or non-living, solid or fluid surfaces rich in nutrients and moisture, microbial biofilm is a matter of great interest due to its major importance for the healthcare community. Depending on common strategies such as mutual protection and hibernation (quiescent bacteria), the resistance, survival and virulence of microbial communities have large implications for human pathology, clinical environment and biomedical devices. The microbial biofilm is continuously changing, stimulating inflammation, increasing vascular permeability and preventing the action of macrophages. Ab...
Source: Current Pharmaceutical Biotechnology - January 19, 2015 Category: Biotechnology Authors: Mogosanu GD, Grumezescu AM, Huang KS, Bejenaru LE, Bejenaru C Tags: Curr Pharm Biotechnol Source Type: research

[Newsdesk] Research brief
A study provides evidence for an interaction between respiratory syncitial virus (RSV) and Streptococcus pneumonia infections. An analysis of data collected between 1992 and 2009 on hospital admissions for RSV and for pneumococcal pneumonia among US children younger than 2 years shows that the two diseases shared a distinctive spatiotemporal pattern over the study period. Moreover, among children younger than 1 year, 20% of pneumococcal cases were associated with RSV activity and hospital admissions for RSV declined after the introduction of PCV7 vaccination against S pneumoniae. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - January 19, 2015 Category: Infectious Diseases Authors: Jane Bradbury Tags: Newsdesk Source Type: research

Dynamic arterial elastance predicts mean arterial pressure decrease associated with decreasing norepinephrine dosage in septic shock
IntroductionGradual reduction of the dosage of norepinephrine (NE) in patients with septic shock is usually left to the physician?s discretion. No haemodynamic indicator predictive of the possibility of decreasing the NE dosage is currently available at the bedside. The respiratory pulse pressure variation / respiratory stroke volume variation (dynamic arterial elastance (Eadyn)) ratio has been proposed as an indicator of vascular tone. The purpose of this study was to determine whether Eadyn can be used to predict the decrease in arterial pressure when decreasing the NE dosage in resuscitated septic patients. Methods: A p...
Source: Critical Care - January 19, 2015 Category: Intensive Care Authors: Pierre-Grégoire GuinotEugénie BernardMélanie LevrardHervé DupontEmmanuel Lorne Source Type: research

The Possibility of Using the ICR Mouse as an Animal Model to Assess Antimonkeypox Drug Efficacy
Summary As a result of the conducted experimental studies on intranasal challenge of ICR mice, rabbits and miniature pigs (even in the maximum variant) with the doses of 4.0–5.5 lg PFU of monkeypox virus (MPXV), some clinical signs such as purulent conjunctivitis, blepharitis and ruffled fur were found only in mice. The 50% infective dose (CID50) of MPXV for these animals estimated by the presence of external clinical signs was 4.8 lg PFU, and LID50 estimated by the virus presence in the lungs of mice 7 days post‐infection taking into account its 10% application in the animal respiratory tract was 1.4 lg PFU. When stu...
Source: Transboundary and Emerging Diseases - January 19, 2015 Category: Veterinary Research Authors: Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, Ar. A. Sergeev, O. V. Pyankov, S. A. Bodnev, D. O. Galahova, A. S. Zamedyanskaya, K. A. Titova, A. G. Glotov, O. S. Taranov, V. V. Omigov, L. N. Shishkina, A. P. Agafonov, A. N. Sergeev Tags: Original Article Source Type: research

The Study of Psychological Personality Profile of Patients Experiencing Bronchial Asthma and Chronic Obstructive Pulmonary Disease
Publication date: 7 January 2015 Source:Procedia - Social and Behavioral Sciences, Volume 166 Author(s): E. Ilyina , V. Zhukova The modern tempo and living conditions led to the growth of the factors, provoking the development of a great number of human diseases. At present moment the medical science is going through a great burst of respiratory diseases. The most wide-spread diseases, which cause great economic losses, are bronchial asthma and chronic obstructive pulmonary disease. Numerous studies showed that anxiously depressive states of the patients with the mentioned pathology are accompanied by quite widespread ps...
Source: Procedia Social and Behavioral Sciences - January 19, 2015 Category: Psychiatry & Psychology Source Type: research

Esophageal versus surface recording of diaphragm compound muscle action potential
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - January 19, 2015 Category: Internal Medicine Authors: Karin A. Ackermann, Lukas Brander, Daniel Tuchscherer, Ralph Schröder, Stephan M. Jakob, Jukka Takala, Werner J. Z'Graggen Tags: Short Reports Source Type: research

Out-of-Hospital Mortality Among Patients Receiving Methadone for Noncancer Pain
ImportanceGrowing methadone use in pain management has raised concerns regarding its safety relative to other long-acting opioids. Methadone hydrochloride may increase the risk for lethal respiratory depression related to accidental overdose and life-threatening ventricular arrhythmias.ObjectiveTo compare the risk of out-of-hospital death in patients receiving methadone for noncancer pain with that in comparable patients receiving sustained-release (SR) morphine sulfate.Design, Setting, and ParticipantsA retrospective cohort study was conducted using Tennessee Medicaid records from 1997 through 2009. The cohort included pa...
Source: JAMA Internal Medicine - January 19, 2015 Category: Internal Medicine Source Type: research

IJERPH, Vol. 12, Pages 986-1002: Risk Communication Concerning Welding Fumes for the Primary Preventive Care of Welding Apprentices in Southern Brazil
This study’s aim was to assess the perceptions of welding apprentices concerning welding fumes being associated with respiratory and cardiovascular disorders and assess the implementation of risk communication as a primary prevention tool in the welding training process. This quasi-experimental, non-randomized study with before-and-after design was conducted with 84 welding apprentices in Southern Brazil. Poisson Regression analysis was used. Relative Risk was the measure used with a 95% confidence interval and 5% (p ≤ 0.05) significance level. Significant association was found between perceptions of worsened symptoms ...
Source: International Journal of Environmental Research and Public Health - January 19, 2015 Category: Environmental Health Authors: Marta Cezar-VazClarice BonowJoana Vaz Tags: Article Source Type: research

How and Why Overcome the Impediments to Resolution: Lessons from rhinolophid and hipposiderid Bats
In this study, we generated a novel approximately 10-kb molecular data set of 19 nuclear exon and intron gene fragments for 40 bat species to elucidate the phylogenetic relationships within the families Rhinolophidae and Hipposideridae. We estimated divergence times and explored potential reasons for any incongruent phylogenetic signal. We demonstrated the effects of outlier taxa and genes on phylogenetic reconstructions and compared the relative performance of intron and exon data to resolve phylogenetic relationships. Phylogenetic analyses produced a well-resolved phylogeny, supporting the familial status of Hipposiderid...
Source: Molecular Biology and Evolution - January 19, 2015 Category: Molecular Biology Authors: Foley, N. M., Thong, V. D., Soisook, P., Goodman, S. M., Armstrong, K. N., Jacobs, D. S., Puechmaille, S. J., Teeling, E. C. Tags: Fast Track Source Type: research

Antibodies against the majority subunit of Type IV pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS‐dependent manner and confer therapeutic resolution of experimental otitis media
Summary Despite resulting in a similar overall outcome, unlike antibodies directed against the DNABII protein, integration host factor (IHF), which induce catastrophic structural collapse of biofilms formed by nontypeable Haemophilus influenzae (NTHI), those directed against a recombinant soluble form of PilA [the majority subunit of Type IV pili (Tfp) produced by NTHI], mediated gradual ‘top‐down’ dispersal of NTHI from biofilms. This dispersal occurred via a mechanism that was dependent upon expression of both PilA (and by inference, Tfp) and production of AI‐2 quorum signaling molecules by LuxS. The addition of ...
Source: Molecular Microbiology - January 19, 2015 Category: Microbiology Authors: Laura A. Novotny, Joseph A. Jurcisek, Michael O. Ward, Zachary B. Jordan, Steven D. Goodman, Lauren O. Bakaletz Tags: Research Article Source Type: research