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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

Critical role of RIG‐I‐like receptors in inflammation in chronic obstructive pulmonary disease
ConclusionOur results suggested that MDA‐5, but not RIG‐I, may plays a critical role in airway inflammation in COPD. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 3, 2014 Category: Respiratory Medicine Authors: Qiurui Zhang, Huanying Wan, Shaoguang Huang, Yan Zhang, Yanchun Wang, Xiaokui Guo, Ping He, Min Zhou Tags: Original Article Source Type: research

Ectopic pancreas in a giant mediastinal cyst
We present a case of an ectopic pancreas located in a giant mediastinal cyst in an 18‐year old male. He presented with symptoms of dyspnea due to external compression of the cyst on the left main bronchus. Complete surgical resection was performed through median sternotomy, with relief of the bronchial compression postoperatively. Literature review showed twenty previously reported cases. These masses were usually large (>10cm), almost exclusively located in the anterior mediastinum, predominately cystic in nature, and generally benign. Surgical resection was performed in all reported cases with a favorable prognosis....
Source: The Clinical Respiratory Journal - July 3, 2014 Category: Respiratory Medicine Authors: Wilson W. Li, Wim Jan Boven, Roy R. Jurhill, Peter I. Bonta, Jouke T. Annema, Bas A. Mol Tags: Case Report Source Type: research

Imaging findings from a case of pleural low‐grade fibromyxoid sarcoma similar to mesothelioma with pleural effusion
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 3, 2014 Category: Respiratory Medicine Authors: Wenjie Liang, Shunliang Xu Tags: Other Source Type: research

A Case of Pulmonary Sarcoidosis with Endobronchial Nodules
We report a case of sarcoidosis with lung involvements and endobronchial nodules as confirmed by bronchial biopsy. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 3, 2014 Category: Respiratory Medicine Authors: Xiao‐Qing Ji, Li‐Xia Wang, De‐Gan Lu Tags: Other Source Type: research

Mortality prediction models in acute respiratory failure treated with extracorporeal membrane oxygenation: it must be firstly designed for clinicians and beside use
No description available (Source: Critical Care)
Source: Critical Care - July 3, 2014 Category: Intensive Care Authors: Matthieu SchmidtDavid Pilcher Source Type: research

Rapid spread of the novel respiratory syncytial virus A ON1 genotype, central Italy, 2011 to 2013
(Source: Eurosurveillance latest news)
Source: Eurosurveillance latest news - July 3, 2014 Category: Infectious Diseases Source Type: research

A deafness-associated tRNAHis mutation alters the mitochondrial function, ROS production and membrane potential
In this report, we investigated the molecular genetic mechanism underlying the deafness-associated mitochondrial tRNAHis 12201T>C mutation. The destabilization of a highly conserved base-pairing (5A-68U) by the m.12201T>C mutation alters structure and function of tRNAHis. Using cybrids constructed by transferring mitochondria from lymphoblastoid cell lines derived from a Chinese family into mtDNA-less (o) cells, we showed ~70% decrease in the steady-state level of tRNAHis in mutant cybrids, compared with control cybrids. The mutation changed the conformation of tRNAHis, as suggested by slower electrophoretic mobility...
Source: Nucleic Acids Research - July 3, 2014 Category: Research Authors: Gong, S., Peng, Y., Jiang, P., Wang, M., Fan, M., Wang, X., Zhou, H., Li, H., Yan, Q., Huang, T., Guan, M.-X. Tags: RNA Source Type: research

Does prolonged onset of symptoms have a prognostic significance in community‐acquired pneumonia?
ConclusionsApproximately 15% of patients diagnosed with CAP had POS. Risk factors associated with POS were previous corticosteroids and antibiotic therapy, alcoholism and less severe pneumonia. POS was associated with a higher rate of suppurative complications and less need for ICU admission. (Source: Respirology)
Source: Respirology - July 3, 2014 Category: Respiratory Medicine Authors: Francisco Sanz, Marcos I. Restrepo, Estrella Fernández‐Fabrellas, Ángela Cervera, María Luisa Briones, Laura Novella, María Carmen Aguar, Eusebi Chiner, Juan F. Fernandez, José Blanquer Tags: Original Article Source Type: research

Roles of Ki‐67, p53, transforming growth factor‐β and lysyl oxidase in the metastasis of lung cancer
ConclusionsLOX and TGF‐β may play roles in metastatic AC. LOX and TGF‐β may become markers of metastatic disease and inhibition could be explored for treatment. (Source: Respirology)
Source: Respirology - July 3, 2014 Category: Respiratory Medicine Authors: Omer Araz, Elif Demirci, Elif Yilmazel Ucar, Muhammet Calik, Adem Karaman, Irmak Durur‐Subasi, Ebru Orsal, Mahmut Subasi, Ferah Daloglu, Metin Akgun Tags: Original Article Source Type: research

Clinical course and prognostic factors of pulmonary aspergilloma
ConclusionsA significant portion of pulmonary aspergilloma changed size in our population. The prevalence of clinically significant haemoptysis was associated with absolute size of cavity and mass of aspergilloma. (Source: Respirology)
Source: Respirology - July 3, 2014 Category: Respiratory Medicine Authors: Jung‐Kyu Lee, Yeon Joo Lee, Sung Soo Park, Jong Sun Park, Young‐Jae Cho, Young Sik Park, Ho Il Yoon, Choon‐Taek Lee, Jae Ho Lee Tags: Original Article Source Type: research

Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells.
Abstract Bile acids resulting from the aspiration of gastroesophageal refluxate are often present in the lower airways of people with cystic fibrosis and other respiratory distress diseases. Surprisingly, there is little or no information on the modulation of airway epithelial ion transport by bile acids. The secretory effect of a variety of conjugated and unconjugated secondary bile acids was investigated in Calu-3 airway epithelial cells grown under an air-liquid interface and mounted in Ussing chambers. Electrogenic transepithelial ion transport was measured as short-circuit current (Isc). The taurine- conjugate...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - July 3, 2014 Category: Cytology Authors: Hendrick SM, Mroz MS, Greene CM, Keely SJ, Harvey BJ Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Attenuation of LPS-induced Lung Vascular Stiffening by Lipoxin Reduces Lung Inflammation.
This study investigated changes in extracellular matrix (ECM) remodeling and tissue stiffness in the model of LPS-induced inflammation and examined a role of lipoxin analog eLXA4, in reduction of stiffness dependent exacerbation of inflammatory process. Methodology: Atomic force microscopy measurements of live lung slices were used to directly measuree local tissue stiffness changes induced by intratracheal injection of LPS. Effects of LPS on ECM properties and inflammatory response were evaluated in the animal model of LPS-induced lung injury, live lung tissue slices, and pulmonary endothelial cell (EC) culture. Results: ...
Source: Am J Respir Cell Mol... - July 3, 2014 Category: Respiratory Medicine Authors: Meng F, Mambetsariev I, Tian Y, Beckham Y, Meliton A, Leff A, Gardel ML, Allen MJ, Birukov KG, Birukova AA Tags: Am J Respir Cell Mol Biol Source Type: research

The Compromise of Macrophage Functions by Hyperoxia is Attenuated by Ethacrynic Acid via Inhibition of NF-κB-mediated Release of HMGB1.
Abstract The prolonged exposure to hyperoxia can compromise macrophage functions and contribute to the development of ventilator-associated pneumonia (VAP). High levels of extracellular high mobility group box-1 (HMGB1) in the airways of mice exposed to hyperoxia can directly cause macrophage dysfunction. Hence, inhibition of the release of nuclear HMGB1 into the extracellular milieu may help to maintain macrophage functions under hyperoxic conditions. The present study investigates whether ethacrynic acid (EA) affects hyperoxia-induced HMGB1 release from macrophages and improves their functions. Macrophage-like RA...
Source: Am J Respir Cell Mol... - July 3, 2014 Category: Respiratory Medicine Authors: Wang M, Gorasiya S, Antoine DJ, Sitapara RA, Wu W, Sharma L, Yang H, Ashby Jr CR, Vasudevan D, Zur M, Thomas DD, Mantell LL Tags: Am J Respir Cell Mol Biol Source Type: research

Hospital-level variation in intensive care unit admission and critical care procedures for patients hospitalized for pulmonary embolism.
Conclusions:Hospitals vary widely in ICU admission rates for acute PE without a detectable impact on mortality, cost, or readmission. Patients admitted to ICUs in higher utilizing hospitals received many critical care procedures less often, suggesting that these patients may have had weaker indications for ICU admission. Hospitals with greater ICU admission may be appropriate targets for improving efficiency in ICU admissions. Background: Variation in the use of intensive care units (ICU) for low-risk conditions contributes to health system inefficiency. We sought to examine the relationship between ICU utilization for...
Source: Chest - July 3, 2014 Category: Respiratory Medicine Authors: Admon AJ, Seymour CW, Gershengorn HB, Wunsch H, Cooke CR Tags: Chest Source Type: research

Unique Predictors of Mortality in Patients With Pulmonary Arterial Hypertension Associated With Systemic Sclerosis in the Reveal Registry.
Conclusions:Patients with SSc-APAH have higher mortality rates than non-SSc-CTD-APAH patients. Identifying SSc-APAH patients who are at particularly high risk of death, including elderly males and patients with low baseline SBP or 6MWD, or markedly elevated mRAP or PVR, will enable clinicians to identify patients who may benefit from closer monitoring and more aggressive treatment. Registered #NCT00370214. Background: Patients with pulmonary arterial hypertension associated with systemic sclerosis (SSc-APAH) experience higher mortality rates than patients with idiopathic disease and those with...
Source: Chest - July 3, 2014 Category: Respiratory Medicine Authors: Chung L, Farber HW, Benza R, Miller DP, Parsons L, Hassoun PM, McGoon M, Nicolls MR, Zamanian RT Tags: Chest Source Type: research

Predicting Mortality and Morbidity after Elective Cardiac Surgery Using Vasoactive-Inflammatory Biomarkers; with and without the EuroSCORE model.
Conclusion:In elective cardiac surgery pre-operative levels of MR-proADM and CT-proET-1 are predictors of 30-days mortality and could improve the predictive accuracy of the EuroSCORE. Further research should confirm the place of these new biomarkers in the prediction of mortality and identification of patients at risk. Background: In cardiac surgery, preoperative mortality risk assessment tools like the EuroSCORE helps to guide physicians in optimizing perioperative care of patients. In this study, we investigated the value of preoperative levels of inflammatory (PCT) and vasoactive (CT-proAVP, MR-proANP, MR-proADM, CT...
Source: Chest - July 3, 2014 Category: Respiratory Medicine Authors: Schoe A, Schippers EF, Ebmeyer S, Struck J, Klautz RJ, de Jonge E, van Dissel JT Tags: Chest Source Type: research

Prognostic value of plasma Heart-type Fatty Acid Binding Protein in patients with acute Pulmonary Embolism: a Meta-analysis.
Conclusion:H-FABP is associated with an increased risk of mortality or complicated clinical events in patients with acute PE across different studies with a high degree of clinical and methodological diversity. The result suggests that H-FABP has significant prognostic value for acute PE. Background: Several recent studies have described Heart-type fatty acid-binding protein (H-FABP) from early blood samples as a predictor of outcome in acute pulmonary embolism (PE). This systematic review aims to determine the prognostic value of H-FABP aimed for use in patients with acute PE. Methods: Studies published prior to J...
Source: Chest - July 3, 2014 Category: Respiratory Medicine Authors: Ruan LB, He L, Zhao S, Zhu P, Li WY Tags: Chest Source Type: research

Effect of oxygen and acetazolamide on nocturnal cardiac conduction, repolarization and arrhythmias in pre-capillary pulmonary hypertension and sleep-disturbed breathing.
Conclusions:In PH-patients with SDB, NOT reduces nocturnal heart rate and QTc in the morning thus favorably modifying prognostic markers. Clinical Trial Registration:This trial is registered at NTC-01427192. Background: Sleep-disturbed breathing (SDB) is common in patients with pre-capillary pulmonary hypertension (PH). Nocturnal oxygen therapy (NOT) and acetazolamide improve SDB in PH-patients and NOT improves exercise capacity. We investigated the effect of NOT and acetazolamide on nocturnal cardiac conduction, repolarization and arrhythmias in patients with PH and SDB. Methods: In a randomize...
Source: Chest - July 3, 2014 Category: Respiratory Medicine Authors: Schumacher DS, Müller-Mottet S, Hasler ED, Hildenbrand FF, Keusch S, Speich R, Bloch KE, Ulrich S Tags: Chest Source Type: research

Increased Day-To-Day Variability of Forced Oscillatory Resistance in Poorly Controlled or Persistent Paediatric Asthma.
Conclusions:Increased day-to-day FOT variability exists in asthmatic school-aged children. Day-to-day Rrs variability was associated with asthma severity and with asthma control. FOT may be useful objective monitoring tool in paediatric asthma and warrants further study. Background: Paediatric asthma lacks sensitive objective measures for asthma monitoring. The forced oscillation technique (FOT) offers strong feasibility across the paediatric age range but relationships between FOT parameter day-to-day variability and paediatric asthma severity and control are unknown. Methods: Day-to-day variability in FOT respira...
Source: Chest - July 3, 2014 Category: Respiratory Medicine Authors: Robinson PD, Brown NJ, Turner M, Van Asperen P, Selvadurai H, King GG Tags: Chest Source Type: research

Acute Hemodynamic Effects of Riociguat in Patients with Pulmonary Hypertension Associated with Diastolic Heart Failure (DILATE-1): A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Study.
Conclusions:In patients with HFpEF and PH, riociguat was well tolerated, had no significant effect on mPAP, and improved exploratory hemodynamic and echocardiographic parameters. Trial; No.: NCT01172756; URL: Background: Deficient nitric oxide- soluble guanylate cyclase (sGC)-cGMP signaling results from endothelial dysfunction and may underlie impaired cardiac relaxation in patients with heart failure with preserved left ventricular ejection fraction (HFpEF) and pulmonary hypertension (PH). The acute hemodynamic effects of riociguat, a novel sGC stimulator, were chara...
Source: Chest - July 3, 2014 Category: Respiratory Medicine Authors: Bonderman D, Pretsch I, Steringer-Mascherbauer R, Jansa P, Rosenkranz S, Tufaro C, Bojic A, Lam CS, Frey R, Ochan Kilama M, Unger S, Roessig L, Lang IM Tags: Chest Source Type: research

Cohnella nanjingensis sp. nov., an extracellular polysaccharide-producing bacterium isolated from soil.
Abstract A Gram-positive, rod-shaped, endospore-forming bacterium, strain D45(T), was isolated from soil in Nanjing, China. The organism grew optimally at 30 °C, pH 7.0 and with 0% NaCl (w/v), respectively. The 16S rRNA gene sequence of the isolate showed similarities lower than 97 % with respect to species of the genus Cohnlla. The predominant respiratory quinone was MK-7, with MK-6 present as a minor component; anteiso-C15:0 and iso-C16:0 were the major fatty acids. The polar lipids of strain D45(T) were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, two aminophospholipids, four phosphol...
Source: International Journal of Systematic and Evolutionary Microbiology - July 3, 2014 Category: Microbiology Authors: Huang Z, Yu YJ, Bao YY, Xia L, Sheng XF, He LY Tags: Int J Syst Evol Microbiol Source Type: research

Lacihabitans soyangensis gen. nov., sp. nov., a new member of the family Cytophagaceae, isolated from a fresh water reservoir.
Abstract A Gram-staining-negative, non-motile and yellow-pigmented bacterium, designated strain HME6675T, was isolated from fresh water of a reservoir in Korea. The major fatty acids of strain HME6675T were iso-C15:0 (33.4%) and summed feature 3 (comprising C16:1 ω6c and/or C16:1 ω7c; 31.3%). The major respiratory quinone was MK-7. The polar lipids were phosphatidylethanolamine, one unidentified aminolipid, one unidentified aminophospholipid and three unidentified polar lipids. The DNA G+C content of strain HME6675T was 37.7 mol%. A phylogenetic tree based on 16S rRNA gene sequences showed that strain HME6675T fo...
Source: International Journal of Systematic and Evolutionary Microbiology - July 3, 2014 Category: Microbiology Authors: Joung Y, Kim H, Kang H, Lee BI, Ahn TS, Joh K Tags: Int J Syst Evol Microbiol Source Type: research

Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Abstract The response to influenza virus (IAV) infection and severity of disease is highly variable in humans. We hypothesized that one factor contributing to this variability is the presence of specific respiratory tract (RT) microbes. One such microbe is Streptococcus pneumoniae (Sp) that is carried asymptomatically in the RT of many humans. In a mouse co-infection model we found that in contrast to secondary bacterial infection that exacerbates disease, Sp colonization 10 days prior to IAV protects from virus-induced morbidity and lung pathology. Using mutant Sp strains, we identified a critical role for the bac...
Source: Virology - July 3, 2014 Category: Virology Authors: Wolf AI, Strauman MC, Mozdzanowska K, Williams KL, Osborne LC, Shen H, Liu Q, Garlick D, Artis D, Hensley SE, Caton AJ, Weiser JN, Erikson J Tags: Virology Source Type: research

Gill remodeling in three freshwater teleosts in response to high environmental ammonia.
Abstract The present study aimed to determine whether gill macro- and microstructure show compensatory responses in three freshwater fish differing in their sensitivity to high environmental ammonia (HEA). The highly ammonia-sensitive salmonid Oncorhynchus mykiss (rainbow trout), the less ammonia-sensitive cyprinid Cyprinus carpio (common carp) and the highly ammonia-resistant cyprinid Carassius auratus (goldfish) were used as test species and were exposed for 0h (control), 3h, 12h, 24h, 48h, 84h and 180h to 1mM ammonia (as NH4HCO3; pH 7.9). In cyprinids, dramatic alterations were initiated quickly evident by thick...
Source: Aquatic Toxicology - July 3, 2014 Category: Toxicology Authors: Sinha AK, Matey V, Giblen T, Blust R, De Boeck G Tags: Aquat Toxicol Source Type: research

Granulomatosis with Polyangiitis and Severe Respiratory Involvement
(Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - July 3, 2014 Category: Emergency Medicine Authors: Benzeeta Pinto, Varun Dhir, Pawan K. Singh, Kiran Krishne Gowda, Aman Sharma Source Type: research

Association of vitamin D with respiratory outcomes in Canadian children
thilselvan (Source: European Journal of Clinical Nutrition)
Source: European Journal of Clinical Nutrition - July 2, 2014 Category: Nutrition Authors: S J NirubanK AlagiakrishnanJ BeachA Senthilselvan Source Type: research

Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life
Conclusions: In healthy infants, formula with DHA/ARA was associated with lower incidence of common respiratory symptoms and illnesses, as well as diarrhea. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - July 2, 2014 Category: Pediatrics Authors: Alexandre LapillonneNitida PastorWeihong ZhuangDeolinda Scalabrin Source Type: research

Oxygen‐enhanced 3D radial ultrashort echo time magnetic resonance imaging in the healthy human lung
The purpose of this work was to use 3D radial ultrashort echo time (UTE) MRI to perform whole‐lung oxygen‐enhanced (OE) imaging in humans. Eight healthy human subjects underwent two 3D radial UTE MRI acquisitions (TE = 0.08 ms): one while breathing 21% O2 and the other while breathing 100% O2. Scans were each performed over 5 min of free breathing, using prospective respiratory gating. For comparison purposes, conventional echo time (TE = 2.1 ms) images were acquired simultaneously during each acquisition using a radial " outward‐inward" k‐space trajectory. 3D percent OE maps were generated from these...
Source: NMR in Biomedicine - July 2, 2014 Category: Radiology Authors: Stanley J. Kruger, Sean B. Fain, Kevin M. Johnson, Robert V. Cadman, Scott K. Nagle Tags: Special issue research article Source Type: research

Self‐gated bSSFP sequences to detect iron‐labeled cancer cells and/or metastases in vivo in mouse liver at 7 Tesla
ConclusionCombining a self‐gating technique with bSSFP sequences at 7T provides high‐resolution 3D artifact‐free abdominal images of small animals. J. Magn. Reson. Imaging 2014. © 2014 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - July 2, 2014 Category: Radiology Authors: Emeline J. Ribot, Tom J. Duriez, Aurélien J. Trotier, Eric Thiaudiere, Jean‐Michel Franconi, Sylvain Miraux Tags: Technical Note Source Type: research

Stuve–Wiedemann syndrome: Is it underrecognized?
Stuve–Wiedemann Syndrome (SWS) (OMIM #601559) is an autosomal recessive disorder characterized by skeletal changes, bowing of the lower limb, severe osteoporosis and joint contractures, episodic hyperthermia, frequent respiratory infections, feeding problems and high mortality in early life. It is caused by mutation in the leukemia inhibitory factor receptor gene (LIFR; 151443) on chromosome 5p13. We provide the clinical follow‐up and molecular aspects of six new patients who carried the same novel mutation in the LIFR gene (p.Arg692X) and three patients carried a common haplotype at the LIFR locus supporting a founder...
Source: American Journal of Medical Genetics Part A - July 2, 2014 Category: Genetics & Stem Cells Authors: Gözde Yeşil, Anne Sophie Lebre, Sofia Dos Santos, Ömer Güran, Ilke Ipek Özahi, Valeria Cormier Daire, Tülay Güran Tags: Research Article Source Type: research

A bovine model of a respiratory Parachlamydia acanthamoebae infection
This study aimed to evaluate the pathogenicity of Parachlamydia (P.) acanthamoebae as a potential agent of lower respiratory tract disease in a bovine model of induced lung infection. Intrabronchial inoculation with P. acanthamoebae was performed in healthy calves aged 2 to 3 months using two challenge doses: 108 and 1010 bacteria per animal. Controls received 108 heat inactivated bacteria. While challenge with 108 viable Parachlamydia resulted in a mild degree of general indisposition, 1010 bacteria induced a more severe respiratory illness becoming apparent 1 – 2 days post inoculation (dpi), affecting 9/9 (100%) anim...
Source: FEMS Immunology and Medical Microbiology - July 2, 2014 Category: Microbiology Authors: Markus Lohr, Annette Prohl, Carola Ostermann, Elisabeth Liebler‐Tenorio, Wieland Schroedl, Sébastien Aeby, Gilbert Greub, Petra Reinhold Tags: Research Paper Source Type: research

Paraneoplastic pemphigus associated with fatal bronchiolitis obliterans and appearance of anti‐BP180 antibodies in the late stage of the disease
We report a case of PNP associated with follicular lymphoma and BO, which showed findings suggesting coexistence of bullous pemphigoid (BP). The patient showed bullous and ulcerative lesions on the lips and oral cavity, and flaccid blisters on the trunk and thighs associated with anti‐desmoglein (Dsg)3 antibodies. At later disease stage after commencement of treatment, anti‐BP180 antibodies and tense blister formation were observed. It was proposed that persistent interface dermatitis is the first event in PNP, and subsequently induce the production of autoantibodies to Dsg and components of the basement membrane zone,...
Source: The Journal of Dermatology - July 2, 2014 Category: Dermatology Authors: Miwa Kanaoka, Setsuko Matsukura, Hideyuki Ishikawa, Midori Matsuura, Norito Ishii, Takashi Hashimoto, Michiko Aihara Tags: Concise Communication Source Type: research

Patients with very‐late‐onset schizoprhenia‐like psychosis have higher mortality rates than elderly patients with earlier onset schizophrenia
ConclusionPatients with VLOSLP, especially men, are at even higher risk of death than schizophrenia patients with earlier onset. Physical comorbidities and accidents in the VLOSLP group mostly explained this result. Targeted clinical interventions with effective collaboration between psychiatry and primary and specialist‐level somatic care are crucial to reduce their excess mortality. Copyright © 2014 John Wiley & Sons, Ltd. (Source: International Journal of Geriatric Psychiatry)
Source: International Journal of Geriatric Psychiatry - July 2, 2014 Category: Geriatrics Authors: Tiina Talaslahti, Hanna‐Mari Alanen, Helinä Hakko, Matti Isohanni, Unto Häkkinen, Esa Leinonen Tags: Research Article Source Type: research

An analysis of microbiota-targeted therapies in patients with avian influenza virus subtype H7N9 infection
Conclusions: Elderly patients infected with the influenza A (H7N9) virus are considered a high-risk group for developing secondary bacterial infection. Microbiota restoration treatment reduced the incidence of enterogenous secondary infection, but not exogenous respiratory infection. The prophylactic effects of microbiota restoration strategies for secondary infection were unsatisfactory in elderly and critically ill patients. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - July 2, 2014 Category: Infectious Diseases Authors: Haifeng LuChunxia ZhangGuirong QianXinjun HuHua ZhangChunlei ChenWeifeng LiangHainv GaoYunmei YangLanjuan Li Source Type: research

Acute stress delays brain mitochondrial permeability transition pore opening
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 2, 2014 Category: Neurology Authors: Cécile Batandier, Laurent Poulet, Isabelle Hininger, Karine Couturier, Eric Fontaine, Anne‐Marie Roussel, Frédéric Canini Tags: Original Article Source Type: research

Increased sensitivity to tryptophan bioavailability is a positive adaptation by the human strains of Chlamydia pneumoniae
Summary One of the most significant activities induced by interferon‐gamma against intracellular pathogens is the induction of IDO (indoleamine 2,3‐dioxygenase) expression which subsequently results in the depletion of tryptophan. We tested the hypothesis that human strains of Chlamydia pneumoniae are more sensitive to tryptophan limitation than animal C. pneumoniae strains. The human strains were significantly more sensitive to IFN‐γ than the animal strains in a lung epithelia cell model (BEAS‐2B), with exposure to 1 U ml‐1 IFN‐γ resulting in complete loss of infectious yield of human strains, compared to th...
Source: Molecular Microbiology - July 2, 2014 Category: Microbiology Authors: Anu Chacko, Christopher J. Barker, Kenneth W. Beagley, Mark P. Hodson, Manuel R. Plan, Peter Timms, Wilhelmina M. Huston Tags: Research Article Source Type: research

Efficacy and Safety of Valsartan/Amlodipine Single-Pill Combination in 11,422 Chinese Patients with Hypertension: an Observational Study.
CONCLUSION: This is the first evidence-based real-world data in Chinese hypertensive patients which demonstrate the efficacy and safety of Val/Aml (80/5 mg) SPC. PMID: 24985411 [PubMed - as supplied by publisher] (Source: Advances in Therapy)
Source: Advances in Therapy - July 2, 2014 Category: Drugs & Pharmacology Authors: Hu D, Liu L, Li W Tags: Adv Ther Source Type: research

[Evaluation of ambulatory prescribing for community-acquired pneumonia in children.]
CONCLUSION: Guidelines for CAP in children were insufficiently followed. PMID: 24997731 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - July 2, 2014 Category: Pediatrics Authors: Dubos F, Delvart C, Mordacq C, Lagrée M, Delebarre M, Deschildre A, Martinot A Tags: Arch Pediatr Source Type: research

Gerstmann-Straeussler-Scheinker disease with P102L prion protein gene mutation presenting with rapidly progressive clinical course.
We describe an autopsied case of a Japanese woman with Gerstmann- Straeussler-Scheinker disease (GSS) presenting with a rapidly progressive clinical course. Disease onset occurred at the age of 54 with dementia and gait disturbance. Her clinical course progressively deteriorated until she reached a bedridden state with myoclonus 9 months after onset. Two months later, she reached the akinetic mutism state. Nasal tube feeding was introduced at this point and continued for several years. Electroencephalograms showed diffuse slowing without periodic sharp-wave complexes. Diffusion-weighted magnetic resonance imaging (MRI) sho...
Source: Clinical Neuropathology - July 2, 2014 Category: Pathology Authors: Iwasaki Y, Mori K, Ito M, Nokura K, Tatsumi S, Mimuro M, Kitamoto T, Yoshida M Tags: Clin Neuropathol Source Type: research

The Crossroads of Iron with Hypoxia and Cellular Metabolism: Implications in the Pathobiology of Pulmonary Hypertension.
Abstract The pathologic hallmark of pulmonary arterial hypertension is pulmonary vascular remodeling - characterized by endothelial cell proliferation, smooth muscle hypertrophy, and perivascular inflammation - ultimately contributing to increased pulmonary arterial pressures. Several recent studies have observed that iron deficiency in patients with various forms of pulmonary arterial hypertension is associated with worsened clinical outcome. Iron plays a key role in many cellular processes regulating the response to hypoxia, oxidative stress, cellular proliferation, and cell metabolism. Given the potential import...
Source: Am J Respir Cell Mol... - July 2, 2014 Category: Respiratory Medicine Authors: Robinson JC, Graham BB, Rouault TC, Tuder RM Tags: Am J Respir Cell Mol Biol Source Type: research

FGF2 is Required for Epithelial Recovery, but Not for Pulmonary Fibrosis, in Response to Bleomycin.
Abstract The pathogenesis of pulmonary fibrosis involves lung epithelial injury and aberrant proliferation of fibroblasts, and results in progressive pulmonary scarring and declining lung function. In vitro, Fibroblast Growth Factor 2 (FGF2) promotes myofibroblast differentiation and proliferation in cooperation with the pro-fibrotic growth factor TGF-β1, but the in vivo requirement for FGF2 in the development of pulmonary fibrosis is not known. The bleomycin model of lung injury and pulmonary fibrosis was applied to Fgf2 knockout (Fgf2-/-) and littermate control mice. Weight loss, mortality, pulmonary fibrosis, a...
Source: Am J Respir Cell Mol... - July 2, 2014 Category: Respiratory Medicine Authors: Guzy RD, Stoilov I, Elton TJ, Mecham RP, Ornitz DM Tags: Am J Respir Cell Mol Biol Source Type: research

Mitochondrial-targeted Antioxidant Therapy Decreases TGFβ Mediated Collagen Production in a Murine Asthma Model.
Conclusions Our findings suggest that mitochondria are a critical source of ROS for promoting TGFβ activity that contributes to airway remodeling in allergic asthma. Mitochondrial-targeted antioxidants may be a novel approach for future asthma therapies. PMID: 24988374 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - July 2, 2014 Category: Respiratory Medicine Authors: Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S, Ryan AJ, Rokita AG, Prasad AM, Zabner J, Kline JN, Grumbach IM, Anderson ME Tags: Am J Respir Cell Mol Biol Source Type: research

The NLRP3 Inflammasome/IL-1RI Axis Mediates Innate Immune but Not Adaptive Immune Responses Following PM10 Exposure.
Conclusions: We demonstrate the importance of the lung NLRP3 inflammasome in mediating PM10-exposure associated innate but not adaptive immune responses. Our study highlights a mechanism by which PM10 exposure can contribute to the exacerbation of airway disease but not PM10-facilitated allergic sensitization. PMID: 24988285 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - July 2, 2014 Category: Respiratory Medicine Authors: Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, Hansbro PM, Carlsten C, VanEeden S, Sin DD, McNagny KM, Knight DA Tags: Am J Respir Cell Mol Biol Source Type: research