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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

Response to: Do initial tidal volumes impact acute respiratory distress syndrome development in patients intubated in the emergency department?
We thank Drs Saad, Maybauer, and Maybauer for their comment on our article “High initial tidal volumes in emergency department (ED) patients at risk for acute respiratory distress syndrome (ARDS).” We agree that there is scant literature regarding optimal settings for mechanical ventilation in the ED. Our impetus for conducting this retrospective study was to gain better insight into the delivery of mechanical ventilation for patients intubated in the ED. We believe the editorial misstates our main conclusion. (Source: Journal of Critical Care)
Source: Journal of Critical Care - January 16, 2015 Category: Intensive Care Authors: Michael G. Allison, Michael C. Scott, Kami M. Hu, Michael D. Witting, Michael E. Winters Source Type: research

Exposure to visible mould or dampness at home and sleep problems in children: Results from the LISAplus study.
CONCLUSION: Our data suggests that visible mould or dampness at home might negatively influence sleep in children. The influence of allergic rhinoconjunctivitis on this association needs to be investigated in future studies. PMID: 25601739 [PubMed - as supplied by publisher] (Source: Environmental Research)
Source: Environmental Research - January 16, 2015 Category: Environmental Health Authors: Tiesler CM, Thiering E, Tischer C, Lehmann I, Schaaf B, von Berg A, Heinrich J Tags: Environ Res Source Type: research

Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species.
Abstract Omentin is a relatively novel adipocyte-derived cytokine mainly expressed in visceral adipose tissues. Blood omentin level decreases in the patients with obesity, hypertension, type 2 diabetes and atherosclerosis. We have previously demonstrated that omentin inhibits key pathological processes for hypertension development, including vascular inflammatory responses, contractile reactivity and structural remodeling. In addition, there are several reports demonstrating that omentin prevents cardiac hypertrophy and myocardial ischemic injury. Doxorubicin (DOX) is an effective anti-cancer drug with cardiotoxic ...
Source: Biochemical and Biophysical Research communications - January 16, 2015 Category: Biochemistry Authors: Kazama K, Okada M, Yamawaki H Tags: Biochem Biophys Res Commun Source Type: research

Short- and long-term outcomes of laparoscopic versus open hepatectomy for small malignant liver tumors: a single-center experience
Conclusions Lap-Hx is a good option for selected patients with malignant liver tumors. The short- and long-term outcomes of Lap-Hx also are considered to be acceptable. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - January 15, 2015 Category: Surgery Source Type: research

Non-rigid reconstruction of chest wall defects after resection of musculoskeletal tumors
Conclusion We used non-rigid reconstruction for full thickness resection of the chest wall, and achieved good postoperative outcomes with no grade 4 complications or perioperative mortality. Non-rigid reconstruction using flap transfers and careful respiratory management is a useful method for treating patients requiring chest wall full thickness resection. (Source: Surgery Today)
Source: Surgery Today - January 15, 2015 Category: Surgery Source Type: research

A new method for objectively evaluating childhood nocturnal cough
ConclusionsOur method demonstrated well agreement with the video‐audio recording method in children, and is considered to be highly useful for the objective monitoring of overnight cough in children with respiratory diseases. Pediatr Pulmonol. 2014; 9999:1–9. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - January 15, 2015 Category: Respiratory Medicine Authors: Kota Hirai, Hideyuki Tabata, Mariko Hirayama, Tohru Kobayashi, Yasumasa Oh, Hiroyuki Mochizuki Tags: Original Article: Other Source Type: research

Fully Covered Self-Expandable Metal Stent in Tracheobronchial Disorders: Clinical Experience
Conclusions: The Silmet stent is effective, safe and simple to implant and remove. We suggest its use in cases of tight stenoses, in the treatment of small- to medium-caliber airways or in cases of tortuous airways. (Source: Respiration)
Source: Respiration - January 15, 2015 Category: Respiratory Medicine Source Type: research

Association of Lifestyle and Cardiovascular Risk Factors with Lung Function in a Sample of the Adult Italian Population: A Cross-Sectional Survey
Conclusion: Our data confirm the inverse relationship existing between pulmonary function and cardiovascular risk factors, obesity, dyslipidemias and hypertension, all of which are conditions related to chronic diseases. An early public healthcare intervention on lifestyle could be useful to reduce the decline in pulmonary function. (Source: Respiration)
Source: Respiration - January 15, 2015 Category: Respiratory Medicine Source Type: research

Coronary Artery Disease in Lung Transplant Candidates: Role of Routine Invasive Assessment
Conclusions: The high prevalence of asymptomatic CAD in lung transplant candidates without correlation to a common clinical risk score supports the important role of coronary angiography for the assessment of coronary artery status. This approach might prevent cardiovascular events and improve long-term survival after transplantation.Respiration (Source: Respiration)
Source: Respiration - January 15, 2015 Category: Respiratory Medicine Source Type: research

Percutaneous Lung Thermal Ablation of Non-surgical Clinical N0 Non-small Cell Lung Cancer: Results of Eight Years’ Experience in 87 Patients from Two Centers
Conclusions Oversized and overlapping ablation of N0 NSCLC was well tolerated, effective, with few local tumor progressions, even over long-term follow-up. Increasing tumor size was the main prognostic factor linked to OS, DFS, and local tumor progression. (Source: CardioVascular and Interventional Radiology)
Source: CardioVascular and Interventional Radiology - January 15, 2015 Category: Radiology Source Type: research

Does menopause effect nasal mucociliary clearance time?
Abstract The aim of this study was to investigate the effect of menopause on nasal mucociliary clearance time by comparing the results of premenopausal and postmenopausal women. A total of 60 women met the criteria and were divided into two groups: premenopausal women (n = 30) and postmenopausal women (n = 30). Nasal mucociliary clearance time of these women was measured and compared. Moreover, the correlation between nasal mucociliary clearance time and menopause duration in postmenopausal women was evaluated. Statistical analysis was performed using the SPSS (Statistical Package for the Social Sciences) 13....
Source: European Archives of Oto-Rhino-Laryngology - January 15, 2015 Category: ENT & OMF Source Type: research

Anesthetic Management of Emergent Laparoscopic Bilateral Adrenalectomy in a Patient with a Life-Threatening Cortisol Crisis
We describe the anesthetic management of a patient with an ectopic adrenocorticotropic hormone-secreting tumor, whose condition was rapidly deteriorating due to severe cortisol excess, and emergent adrenalectomy was the only available therapeutic modality. Despite severe metabolic derangement, edema, and incipient respiratory failure, emergent bilateral laparoscopic adrenalectomy was performed and the patient improved sufficiently to undergo surgery for the ectopic lesion without incident. (Source: A&A Case Reports)
Source: A&A Case Reports - January 15, 2015 Category: Anesthesiology Tags: Case Reports: Case Report Source Type: research

Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: From traditional uses to scientific data for its commercial exploitation
Conclusions Pharmacological results have supported some traditional medicinal uses of Oroxylum indicum. Several extracts and their isolates have been reported to exhibit interesting pharmacological properties. These components could be useful as sources of modern medicines following future detailed studies to elucidate their underlying mechanisms, toxicity, synergistic effects and clinical trials. Attention should also be focused on pharmacological studies investigating the traditional uses of the plant, which have not been yet addressed, as well as clinical studies investigating commercial Ayurvedic medicines and other et...
Source: Journal of Ethnopharmacology - January 15, 2015 Category: Drugs & Pharmacology Source Type: research

MyMpn: a database for the systems biology model organism Mycoplasma pneumoniae
MyMpn (http://mympn.crg.eu) is an online resource devoted to studying the human pathogen Mycoplasma pneumoniae, a minimal bacterium causing lower respiratory tract infections. Due to its small size, its ability to grow in vitro, and the amount of data produced over the past decades, M. pneumoniae is an interesting model organisms for the development of systems biology approaches for unicellular organisms. Our database hosts a wealth of omics-scale datasets generated by hundreds of experimental and computational analyses. These include data obtained from gene expression profiling experiments, gene essentiality studies, prot...
Source: Nucleic Acids Research - January 15, 2015 Category: Research Authors: Wodke, J. A. H., Alibes, A., Cozzuto, L., Hermoso, A., Yus, E., Lluch-Senar, M., Serrano, L., Roma, G. Tags: Database issue Source Type: research

HIV‐associated disseminated histoplasmosis in western French Guiana, 2002–2012
We describe the clinical and paraclinical presentation of DH, diagnostic tools, evolution and factors associated with 1‐year mortality in HIV‐infected patients from western French Guiana. Microbiologically proven AIDS‐related DH in Saint Laurent du Maroni's hospital between May 2002 and May 2012 were retrospectively included. Among the 82 patients included, 58 (71%) were male, 44 (53%) presented concurrent histoplasmosis and HIV diagnosis and 63 (80%) had a CD4 cell count under 50 cells μL−1. Almost all patients had weight loss (97%) and fever (95%), while 84% had digestive symptoms (63% diarrhoea), 55% lymphaden...
Source: Mycoses - January 15, 2015 Category: Research Authors: A. Putot, S. Perrin, A. Jolivet, V. Vantilcke Tags: Original Article Source Type: research

Efficacy of Positive Airway Pressure on Brain Natriuretic Peptide in Patients with Heart Failure and Sleep-Disorder Breathing: A Meta-analysis of Randomized Controlled Trials
Conclusion Our meta-analysis of RCTs demonstrated that PAP elicits significant reduction of BNP in patients with HF and SDB. (Source: Lung)
Source: Lung - January 15, 2015 Category: Respiratory Medicine Source Type: research

A mathematical model to predict protein wash out kinetics during whole-lung lavage in autoimmune pulmonary alveolar proteinosis
Whole-lung lavage (WLL) remains the standard therapy for pulmonary alveolar proteinosis (PAP), a process in which accumulated surfactants are washed out of the lung with 0.5–2.0 l of saline aliquots for 10–30 wash cycles. The method has been established empirically. In contrast, the kinetics of protein transfer into the lavage fluid has not been fully evaluated either theoretically or practically. Seventeen lungs from patients with autoimmune PAP underwent WLL. We made accurate timetables for each stage of WLL, namely, instilling, retaining, draining, and preparing. Subsequently, we measured the volumes of both...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Akasaka, K., Tanaka, T., Maruyama, T., Kitamura, N., Hashimoto, A., Ito, Y., Watanabe, H., Wakayama, T., Arai, T., Hayashi, M., Moriyama, H., Uchida, K., Ohkouchi, S., Tazawa, R., Takada, T., Yamaguchi, E., Ichiwata, T., Hirose, M., Arai, T., Inoue, Y., K Tags: CALL FOR PAPERS Source Type: research

A preterm pig model of lung immaturity and spontaneous infant respiratory distress syndrome
Respiratory distress syndrome (RDS) and bronchopulmonary dysplasia remain the leading causes of preterm infant morbidity, mortality, and lifelong disability. Research to improve outcomes requires translational large animal models for RDS. Preterm pigs delivered by caesarian section at gestation days (GD) 98, 100, 102, and 104 were provided 24 h of neonatal intensive care, monitoring (pulse oximetry, blood gases, serum biomarkers, radiography), and nutritional support, with or without intubation and mechanical ventilation (MV; pressure control ventilation with volume guarantee). Spontaneous development of RDS and mortality ...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Caminita, F., van der Merwe, M., Hance, B., Krishnan, R., Miller, S., Buddington, K., Buddington, R. K. Tags: CALL FOR PAPERS Source Type: research

Emerging molecular phenotypes of asthma
Although asthma has long been considered a heterogeneous disease, attempts to define subgroups of asthma have been limited. In recent years, both clinical and statistical approaches have been utilized to better merge clinical characteristics, biology, and genetics. These combined characteristics have been used to define phenotypes of asthma, the observable characteristics of a patient determined by the interaction of genes and environment. Identification of consistent clinical phenotypes has now been reported across studies. Now the addition of various 'omics and identification of specific molecular pathways have moved the...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Ray, A., Oriss, T. B., Wenzel, S. E. Tags: CALL FOR PAPERS Source Type: research

Hyperoxia-induced changes in estradiol metabolism in postnatal airway smooth muscle
Supplemental oxygen, used to treat hypoxia in preterm and term neonates, increases the risk of neonatal lung diseases, such as bronchopulmonary dysplasia (BPD) and asthma. There is a known sex predilection for BPD, but the underlying mechanisms are not clear. We tested the hypothesis that altered, local estradiol following hyperoxia contributes to pathophysiological changes observed in immature lung. In human fetal airway smooth muscle (fASM) cells exposed to normoxia or hyperoxia, we measured the expression of proteins involved in estrogen metabolism and cell proliferation responses to estradiol. In fASM cells, CYP1a1 exp...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Martin, Y. N., Manlove, L., Dong, J., Carey, W. A., Thompson, M. A., Pabelick, C. M., Pandya, H. C., Martin, R. J., Wigle, D. A., Prakash, Y. S. Tags: RAPID REPORT Source Type: research

Metabolic disturbances of the vitamin A pathway in human diaphragmatic hernia
Congenital diaphragmatic hernia (CDH) is a common life-threatening congenital anomaly resulting in high rates of perinatal death and neonatal respiratory distress. Some of the nonisolated forms are related to single-gene mutations or genomic rearrangements, but the genetics of the isolated forms (60% of cases) still remains a challenging issue. Retinoid signaling (RA) is critical for both diaphragm and lung development, and it has been hypothesized that subtle disruptions of this pathway could contribute to isolated CDH etiology. Here we used time series of normal and CDH lungs in humans, in nitrofen-exposed rats, and in s...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Coste, K., J. E. Beurskens, L. W., Blanc, P., Gallot, D., Delabaere, A., Blanchon, L., Tibboel, D., Labbe, A., Rottier, R. J., Sapin, V. Tags: ARTICLES Source Type: research

Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction
Right ventricular (RV) function is a key determinant of survival in patients with both RV and left ventricular (LV) failure, yet the mechanisms of RV failure are poorly understood. Recent studies suggest cardiac metabolism is altered in RV failure in pulmonary hypertension (PH). Accordingly, we assessed mitochondrial content, dynamics, and function in hearts from neonatal calves exposed to hypobaric hypoxia (HH). This model develops severe PH with concomitant RV hypertrophy, dilation, and dysfunction. After 2 wk of HH, pieces of RV and LV were obtained along with samples from age-matched controls. Comparison with control a...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Bruns, D. R., Brown, R. D., Stenmark, K. R., Buttrick, P. M., Walker, L. A. Tags: ARTICLES Source Type: research

Abnormal epithelial structure and chronic lung inflammation after repair of chlorine-induced airway injury
Chlorine is a toxic gas used in a variety of industrial processes and is considered a chemical threat agent. High-level chlorine exposure causes acute lung injury, but the long-term effects of acute chlorine exposure are unclear. Here we characterized chronic pulmonary changes following acute chlorine exposure in mice. A/J mice were exposed to 240 parts per million-hour chlorine or sham-exposed to air. Chlorine inhalation caused sloughing of bronchial epithelium 1 day after chlorine exposure, which was repaired with restoration of a pseudostratified epithelium by day 7. The repaired epithelium contained an abnormal distrib...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Mo, Y., Chen, J., Humphrey, D. M., Fodah, R. A., Warawa, J. M., Hoyle, G. W. Tags: ARTICLES Source Type: research

{alpha}-1-Antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease
The excessive activities of the serine proteinases neutrophil elastase and proteinase 3 are associated with tissue damage in chronic obstructive pulmonary disease. Reduced concentrations and/or inhibitory efficiency of the main circulating serine proteinase inhibitor α-1-antitrypsin result from point mutations in its gene. In addition, α-2-macroglobulin competes with α-1-antitrypsin for proteinases, and the α-2-macroglobulin-sequestered enzyme can retain its catalytic activity. We have studied how serine proteinases partition between these inhibitors and the effects of α-1-antitrypsin mutation...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Sinden, N. J., Baker, M. J., Smith, D. J., Kreft, J.-U., Dafforn, T. R., Stockley, R. A. Tags: ARTICLES Source Type: research

Serotonin 5-HT2 receptor activation prevents allergic asthma in a mouse model
Asthma is an inflammatory disease of the lung characterized by airways hyper-responsiveness (AHR), inflammation, and mucus hyperproduction. Current mainstream therapies include bronchodilators that relieve bronchoconstriction and inhaled glucocorticoids to reduce inflammation. The small molecule hormone and neurotransmitter serotonin has long been known to be involved in inflammatory processes; however, its precise role in asthma is unknown. We have previously established that activation of serotonin 5-hydroxytryptamine (5-HT)2A receptors has potent anti-inflammatory activity in primary cultures of vascular tissues and in ...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Nau, F., Miller, J., Saravia, J., Ahlert, T., Yu, B., Happel, K. I., Cormier, S. A., Nichols, C. D. Tags: ARTICLES Source Type: research

HER2 activation results in {beta}-catenin-dependent changes in pulmonary epithelial permeability
The receptor tyrosine kinase human epidermal growth factor receptor-2 (HER2) is known to regulate pulmonary epithelial barrier function; however, the mechanisms behind this effect remain unidentified. We hypothesized that HER2 signaling alters the epithelial barrier through an interaction with the adherens junction (AJ) protein β-catenin, leading to dissolution of the AJ. In quiescent pulmonary epithelial cells, HER2 and β-catenin colocalized along the lateral intercellular junction. HER2 activation by the ligand neuregulin-1 was associated with tyrosine phosphorylation of β-catenin, dissociation of β-c...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Finigan, J. H., Vasu, V. T., Thaikoottathil, J. V., Mishra, R., Shatat, M. A., Mason, R. J., Kern, J. A. Tags: ARTICLES Source Type: research

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension
In conclusion, Akt isoforms appear to have a unique function within the pulmonary vasculature, with the Akt1 isoform having a dominant role in pulmonary vascular remodeling associated with HPH. The PTEN/Akt1/mTOR signaling pathway will continue to be a critical area of study in the pathogenesis of pulmonary hypertension, and specific Akt isoforms may help specify therapeutic targets for the treatment of pulmonary hypertension. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Tang, H., Chen, J., Fraidenburg, D. R., Song, S., Sysol, J. R., Drennan, A. R., Offermanns, S., Ye, R. D., Bonini, M. G., Minshall, R. D., Garcia, J. G. N., Machado, R. F., Makino, A., Yuan, J. X.- J. Tags: ARTICLES Source Type: research

Efficient intratracheal delivery of airway epithelial cells in mice and pigs
This study aimed to establish a simple method for evaluating cell retention in lungs and to develop reproducible approaches for efficient cell delivery into mouse and pig lungs. Human lung epithelial cells including normal human bronchial/tracheal epithelial (NHBE) cells and human lung epithelial cell line A549 were infected with pSicoR-green fluorescent protein (GFP) lentivirus. GFP-labeled NHBE cells were delivered via a modified intratracheal cell instillation method into the lungs of C57BL/6J mice. Two days following cell delivery, GFP ELISA-based assay revealed a substantial cell-retention efficiency (10.48 ± 2...
Source: AJP: Lung Cellular and Molecular Physiology - January 15, 2015 Category: Respiratory Medicine Authors: Gui, L., Qian, H., Rocco, K. A., Grecu, L., Niklason, L. E. Tags: ARTICLES Source Type: research

Low‐flow veno‐venous extracorporeal carbon dioxide removal in the management of severe status asthmatics: a case report
In this report, we report the use of a novel, minimally invasive, low‐flow extracorporeal carbon dioxide removal device in management of severe hypercapnic acidosis in a patient with life threatening status asthmaticus. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 15, 2015 Category: Respiratory Medicine Authors: Ravindranath Tiruvoipati, Kavi Haji, Sachin Gupta, Gary Braun, Ian Carney, John Botha Tags: Case Report Source Type: research

Improvement of the trigger of a ventilator for non‐invasive ventilation in children: bench and clinical study
ConclusionsThe sensitivity of the IT of a ventilator can be improved for pediatric use. The improvements observed on the bench study were confirmed in pediatric patients. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 15, 2015 Category: Respiratory Medicine Authors: Sonia Khirani, Bruno Louis, Karl Leroux, Adriana Ramirez, Frédéric Lofaso, Brigitte Fauroux Tags: Original Article Source Type: research

Delayed tracheobronchial rupture after caustic ingestion
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 15, 2015 Category: Respiratory Medicine Authors: Anja Edelmann, Alexandra Wald, Udo X. Kaisers, Manuel F. Struck Tags: Letter to the Editor Source Type: research

Feasibility and safety of parietal pleural cryobiopsy during semi‐rigid thoracoscopy
ConclusionsCryobiopsy during semi‐rigid thoracoscopy appears worth to be evaluated in a larger prospective multicenter trial as our preliminary data were promising for efficacy and safety. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 15, 2015 Category: Respiratory Medicine Authors: Aleš Rozman, Luka Camlek, Mateja Marc Malovrh, Izidor Kern, Nicolas Schönfeld Tags: Original Article Source Type: research

Assessment of chronic obstructive pulmonary disease in rural women
Conclusion Most COPD patients have a poor health status and have a history of chronic symptoms before definitely being diagnosed with COPD by spirometry. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - January 15, 2015 Category: Respiratory Medicine Source Type: research

Salvage esophagectomy under bilateral thoracotomy after definitive chemoradiotherapy for aorta T4 thoracic esophageal squamous cell carcinoma: Report of a case
Conclusion Salvage esophagectomy through a right thoracotomy followed by careful observation of the invasion site for possible aortic replacement through a left thoracotomy is an optional procedure for these patients. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - January 15, 2015 Category: Surgery Source Type: research

Surveillance of Noncommunicable Diseases by Community Health Workers in Kerala The Epidemiology of Noncommunicable Diseases in Rural Areas (ENDIRA) Study
Conclusions CHW effectively conducted a large-scale prevalence study of NCD in Kerala, including prevalence of risk factors. In rural Kerala, traditional risk factors were strongly associated with MI and stroke. (Source: Global Heart)
Source: Global Heart - January 15, 2015 Category: Cardiology Source Type: research

Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10
Publication date: Available online 14 January 2015 Source:Redox Biology Author(s): Nuri Gueven , Krystel Woolley , Jason Smith CoenzymeQ10 is a ubiquitous component of cellular membranes and belongs to the class of benzoquinones that mainly differ with regards to the length and composition of their hydrophobic tail. The characteristic quinone group can accept electrons from various biological sources and is converted by a one electron transfer to the unstable semiquinone or by a two electron transfer to the more stable hydroquinone. This feature makes CoQ10 the bona fide cellular electron transfer molecule within the mit...
Source: Redox Biology - January 15, 2015 Category: Biology Source Type: research

Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice
Hepatic fatty acid oxidation (FAO) has long been implicated in the control of eating. Nevertheless, direct evidence for a causal relationship between changes in hepatic FAO and changes in food intake is still missing. Here we tested whether increasing hepatic FAO via adenovirus-mediated expression of a mutated form of the key regulatory enzyme of mitochondrial FAO carnitine palmitoyltransferase 1A (CPT1mt), which is active but insensitive to inhibition by malonyl-CoA, affects eating and metabolism in mice. CPT1mt expression increased hepatocellular CPT1 protein levels. This resulted in an increase in circulating ketone bod...
Source: AJP: Regulatory, Integrative and Comparative Physiology - January 15, 2015 Category: Physiology Authors: Mansouri, A., Pacheco-Lopez, G., Ramachandran, D., Arnold, M., Leitner, C., Prip-Buus, C., Langhans, W., Morral, N. Tags: Obesity, Diabetes and Energy Homeostasis Source Type: research

Differential sensitivity of oxidative and glycolytic muscles to hypoxia-induced muscle atrophy
This study investigated the sensitivity of oxidative and glycolytic muscles to hypoxia-induced muscle atrophy. Male mice were exposed to 8% normobaric oxygen for up to 21 days. Oxidative soleus and glycolytic extensor digitorum longus (EDL) muscles were isolated, weighed, and assayed for expression profiles of the ubiquitin-proteasome system (UPS), the autophagy-lysosome pathway (ALP), and glucocorticoid receptor (GR) and hypoxia-inducible factor-1α (HIF1α) signaling. Fiber-type composition and the capillary network were investigated. Hypoxia-induced muscle atrophy was more prominent in the EDL than the soleus ...
Source: Journal of Applied Physiology - January 15, 2015 Category: Physiology Authors: de Theije, C. C., Langen, R. C. J., Lamers, W. H., Gosker, H. R., Schols, A. M. W. J., Kohler, S. E. Tags: ARTICLES Source Type: research

Respiratory sinus arrhythmia as a surrogate measure of respiratory frequency: validity and robustness to activity in rats
In conclusion, RSA frequency reflected regular respiration frequency independently of the level of activity and appears to be a good surrogate to usual techniques. (Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - January 15, 2015 Category: Physiology Authors: Brouillard, C., Carrive, P., Similowski, T., Sevoz-Couche, C. Tags: INNOVATIVE METHODOLOGY Source Type: research

Expression of surface platelet receptors (cd62p and cd41/61) in horses with recurrent airway obstruction (rao)
This study demonstrated the morphological changes in platelets and expression of platelet surface receptors. Despite the decrease of CD62P expression, the observed increased surface expression of CD41/61 on platelets in horses with RAO may contribute to the formation of platelet aggregates in their respiratory system. (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - January 15, 2015 Category: Veterinary Research Source Type: research

Improved metabolic regulation is associated with retinoblastoma protein gene haploinsufficiency in mice
In conclusion, Rb haploinsufficiency provides metabolic advantages in front of acute metabolic stressors and ameliorates body fat gain and metabolic impairments that normally accompany transition from young to mature adult age. (Source: AJP: Endocrinology and Metabolism)
Source: AJP: Endocrinology and Metabolism - January 15, 2015 Category: Endocrinology Authors: Petrov, P. D., Ribot, J., Palou, A., Luisa Bonet, M. Tags: Articles Source Type: research

Phase 2 study of carfilzomib, thalidomide, and dexamethasone as induction/consolidation therapy for newly diagnosed multiple myeloma
This study was registered at http://www.trialregister.nl as #NTR2422. (Source: Blood)
Source: Blood - January 15, 2015 Category: Hematology Authors: Sonneveld, P., Asselbergs, E., Zweegman, S., van der Holt, B., Kersten, M. J., Vellenga, E., van Marwijk-Kooy, M., Broyl, A., de Weerdt, O., Lonergan, S., Palumbo, A., Lokhorst, H. Tags: Multiple Myeloma, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research