Respiratory Medicine research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.
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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.
Amnioinfusion in very early preterm premature rupture of membranes - pregnancy, neonatal and maternal outcomes in the AMIPROM randomised controlled pilot study.
CONCLUSIONS: This pilot study found no major differences in maternal, perinatal or pregnancy outcomes. The study was not designed to show a difference between the groups and the number of survivors too small to draw any conclusions about long -term outcomes. It does signal however that a larger definitive study to evaluate amnioinfusion for improvement in healthy survival is needed. The pilot suggests that with appropriate funding such a study is feasible. PMID: 24265189 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - November 21, 2013 Category: Radiology Authors: Roberts D, Vause S, Martin W, Green P, Walkinshaw S, Bricker L, Beardsmore C, Shaw N, McKay A, Skotny G, Williamson P, Alfirevic Z Tags: Ultrasound Obstet Gynecol Source Type: research
A clinical score (RAPID) to identify those at risk of poor outcome at presentation in patients with pleural infection.
CONCLUSION: The RAPID score may permit risk-stratification of patients with pleural infection at presentation and may be usefu0l in guiding initial management. PMID: 24264558 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - November 21, 2013 Category: Respiratory Medicine Authors: Rahman NM, Kahan BC, Miller RF, Gleeson FV, Nunn AJ, Maskell NA Tags: Chest Source Type: research
Occupational exposure to vapors, gases, dusts and fumes and mortality in relation to chronic obstructive pulmonary disease among Swedish construction workers - a longitudinal cohort study.
CONCLUSIONS: Occupational exposure to airborne pollution increases the mortality risk for COPD, especially among never-smokers. PMID: 24264472 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - November 21, 2013 Category: Respiratory Medicine Authors: Torén K, Järvholm B Tags: Chest Source Type: research
Perception of bronchoconstriction following Methacholine and Eucapnic Voluntary Hyperpnea challenges in elite athletes.
CONCLUSION: Minimal differences in bronchoconstriction-related symptoms' perception between athletes and non-athletes were observed. Among athletes, the presence of an exercise-induced bronchoconstriction/airway hyperresponsiveness, an older age and female gender were associated with slightly higher perception scores. PMID: 24264387 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - November 21, 2013 Category: Respiratory Medicine Authors: Couillard S, Bougault V, Turmel J, Boulet LP Tags: Chest Source Type: research
Nonalcoholic fatty liver disease, nocturnal hypoxia and endothelial function in sleep apnea patients.
CONCLUSION: In a large unselected OSA population, the severity of nocturnal hypoxia was independently associated with steatosis. Pre-existing obesity exacerbated the effects of nocturnal hypoxemia. NAFLD is a potential mechanism of endothelial dysfunction in OSA. PMID: 24264333 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - November 21, 2013 Category: Respiratory Medicine Authors: Minville C, Hilleret MN, Tamisier R, Aron-Wisnewsky J, Clement K, Trocme C, Borel JC, Levy P, Zarski JP, Pepin JL Tags: Chest Source Type: research
Distribution of T cell subsets in bronchoalveolar lavage fluid of patients with mild to moderate COPD is dependent on current smoking status and not airway obstruction.
CONCLUSIONS Current smoking status has a greater impact than airway obstruction on the distribution of T cell subsets in BAL of patients with mild to moderate COPD. This must be considered when the role of T cells in COPD is evaluated. Our results stress the importance of subgrouping COPD patients in terms of smoking. PMID: 24264182 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - November 21, 2013 Category: Respiratory Medicine Authors: Forsslund H, Mikko M, Karimi R, Grunewald J, Wheelock AM, Wahlström J, Sköld CM Tags: Chest Source Type: research
Concordance and discriminatory power of cough measurement devices for individuals with Parkinson's Disease.
CONCLUSIONS: The analog and digital peak airflow meters are suitable alternatives to the gold standard pneumotachograph due to their low cost, portability, ease of use, and high sensitivity relative to normative peak cough airflows. Voluntary cough airflow measures may serve as a noninvasive means of screening for aspiration risk in target populations. Additionally, quantification of cough strength through use of predetermined limens for "weak," "moderate" and "strong" cough may assist clinicians in better describing and tracking cough strength as a contributing factor to aspiration risk. PMID: 24264124 [PubMed - as su...
Source: Chest - November 21, 2013 Category: Respiratory Medicine Authors: Silverman EP, Carnaby-Mann G, Pitts T, Davenport P, Okun MS, Sapienza C Tags: Chest Source Type: research
Delivery of inhalation drugs to children for asthma and other respiratory diseases.
Abstract Infants and children constitute a patient group that have unique requirements in pulmonary drug delivery. Since their lungs develop continuously until they reach adulthood, the airways undergo changes in dimensions and number. Computational models have been devised on the growth dynamics of the airways during childhood, as well as the particle deposition mechanisms in these growing lungs. The models indicate that total aerosol deposition in the body decreases with age, while deposition in the lungs increases with age. This has been observed on paediatric subjects in in vivo studies. Issues unique to childr...
Source: Advanced Drug Delivery Reviews - November 21, 2013 Category: Drugs & Pharmacology Authors: Kwok PC, Chan HK Tags: Adv Drug Deliv Rev Source Type: research
Comparable improvements achieved in chronic obstructive pulmonary disease through pulmonary rehabilitation with and without a structured educational intervention: A randomized controlled trial
ConclusionsThe results of this investigation suggest that disease‐specific group education is not an essential component of pulmonary rehabilitation. Pulmonary rehabilitation based on exercise training is an effective option in the management of patients with COPD if multidisciplinary education cannot be offered. (Source: Respirology)
Source: Respirology - November 21, 2013 Category: Respiratory Medicine Authors: Felicity C. Blackstock, Kate E. Webster, Christine F. McDonald, Catherine J. Hill Tags: Original Article Source Type: research
Reporting of exercise attendance rates for people with chronic obstructive pulmonary disease: A systematic review
Abstract While recommendations for the duration, frequency, mode and intensity of exercise programmes for people with chronic obstructive pulmonary disease (COPD) are specified in consensus statements, criteria for exercise session attendance are less clear. The review questions were: (i) how commonly are a priori criteria and attendance rates reported for people with COPD participating in exercise programmes and (ii) what is the strength of association between attendance and improvements in functional exercise capacity. Database searches identified primary studies of people with COPD participating in exercise or pulmonary...
Source: Respirology - November 21, 2013 Category: Respiratory Medicine Authors: Marie T. Williams, Lucy K. Lewis, Zoe McKeough, Anne E. Holland, Annemarie Lee, Renae McNamara, Anna Phillips, Louise Wiles, Leona Knapman, Sally Wootton, Maree Milross, Tanja Effing Tags: Review Source Type: research
Lack of efficacy of neuromuscular electrical stimulation of the lower limbs in chronic obstructive pulmonary disease patients: A meta‐analysis
Abstract Randomized controlled trials (RCT) were carried out to investigate the role of neuromuscular electrical stimulation (NMES) in patients with chronic obstructive pulmonary disease (COPD). However, these studies have small sample size and different measures for evaluating outcomes, and convey inconclusive results. We carried out a meta‐analysis to assess the effects of NMES to COPD patients.A computerized search was performed through PubMed and Embase databases (up to December 2012) for relevant RCT. Two investigators independently screened the articles. The primary outcome measures were quadriceps strength and exe...
Source: Respirology - November 21, 2013 Category: Respiratory Medicine Authors: Lei Pan, YongZhong Guo, Xunchao Liu, Junhong Yan Tags: Review Source Type: research
Encapsulation into PEG-Liposomes Does Not Improve the Bioavailability of Pulmonary Delivered Salmon Calcitonin
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - November 20, 2013 Category: Respiratory Medicine Tags: article Source Type: research
Influenza and ischaemic heart disease: research challenges and future directions
Observational evidence is mounting that influenza and acute respiratory infections can precipitate major adverse cardiovascular events such as acute myocardial infarction (AMI) in vulnerable groups. Influenza viruses cause seasonal epidemics. Around 50% of infections are asymptomatic1; clinically apparent influenza infection is usually mild and self-limiting, with severe systemic illness affecting a small proportion of people. Deaths typically occur in people at the extremes of age or in those with underlying medical conditions.2 Cardiac pathology in acute influenza infection is thought to result either from direct effects...
Source: Heart - November 20, 2013 Category: Cardiology Authors: Warren-Gash, C. Tags: Drugs: cardiovascular system, Acute coronary syndromes, Venous thromboembolism, Epidemiology, Tobacco use Editorials Source Type: research
State of the evidence: mechanical ventilation with PEEP in patients with cardiogenic shock
The need to provide invasive mechanical ventilatory support to patients with myocardial infarction and acute left heart failure is common. Despite the large number of patients requiring mechanical ventilation in this setting, there are remarkably few data addressing the ideal mode of respiratory support in such patients. Although there is near universal acceptance regarding the use of non-invasive positive pressure ventilation in patients with acute pulmonary oedema, there is more concern with invasive positive pressure ventilation owing to its more significant haemodynamic impact. Positive end-expiratory pressure (PEEP) i...
Source: Heart - November 20, 2013 Category: Cardiology Authors: Wiesen, J., Ornstein, M., Tonelli, A. R., Menon, V., Ashton, R. W. Tags: Reviews Source Type: research
Ischaemic heart disease, influenza and influenza vaccination: a prospective case control study
Conclusions Recent influenza infection was an unrecognised comorbidity in almost 10% of hospital patients. Influenza did not predict AMI, but vaccination was significantly protective but underused. The potential population health impact of influenza vaccination, particularly in the age group 50–64 years, who are at risk for AMI but not targeted for vaccination, should be further explored. Our data should inform vaccination policy and cardiologists should be aware of missed opportunities to vaccinate individuals with ischaemic heart disease against influenza. (Source: Heart)
Source: Heart - November 20, 2013 Category: Cardiology Authors: MacIntyre, C. R., Heywood, A. E., Kovoor, P., Ridda, I., Seale, H., Tan, T., Gao, Z., Katelaris, A. L., Siu, H. W. D., Lo, V., Lindley, R., Dwyer, D. E. Tags: Open access, Editor's choice, Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology Source Type: research
Vaccines for measles, mumps and rubella in children
Abstract BackgroundMumps, measles and rubella (MMR) are serious diseases that can lead to potentially fatal illness, disability and death. However, public debate over the safety of the trivalent MMR vaccine and the resultant drop in vaccination coverage in several countries persists, despite its almost universal use and accepted effectiveness. ObjectivesTo assess the effectiveness and adverse effects associated with the MMR vaccine in children up to 15 years of age. Search methodsFor this update we searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 2), which includes the...
Source: Evidence-Based Child Health: A Cochrane Review Journal - November 20, 2013 Category: Pediatrics Authors: Vittorio Demicheli, Alessandro Rivetti, Maria Grazia Debalini, Carlo Di Pietrantonj Tags: Intervention Review Source Type: research
Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children
Abstract BackgroundRespiratory syncytial virus (RSV) is one of the most important viral pathogens causing acute respiratory infections, resulting in about 3.4 million hospitalisations annually in children under five. Palivizumab is the only product approved for prevention of serious RSV disease, as motavizumab is no longer being developed for this condition. The efficacy and safety of palivizumab has been evaluated in randomized controlled trials (RCTs) and a large number of economic evaluations (EEs) have tested its cost‐effectiveness. ObjectivesTo assess the effectiveness and safety of palivizumab prophylaxis in reduci...
Source: Evidence-Based Child Health: A Cochrane Review Journal - November 20, 2013 Category: Pediatrics Authors: Tea Andabaka, Jason W Nickerson, Maria Ximena Rojas‐Reyes, Juan David Rueda, Vesna Bacic Vrca, Bruno Barsic Tags: Intervention Review Source Type: research
Cochrane in context: Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children
Abstract Cochrane Review: Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children Andabaka T, Nickerson JW, Rojas‐Reyes MX, Rueda JD, Bacic Vrca V, Barsic B. Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD006602. DOI: 10.1002/14651858.CD006602.pub4 This companion piece to the review, “Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children,” contains the following pieces: The abstract of the review A commentary from one or...
Source: Evidence-Based Child Health: A Cochrane Review Journal - November 20, 2013 Category: Pediatrics Authors: Tea Andabaka, Maria Ximena Rojas‐Reyes Tags: Commentary Source Type: research
The diagnostic accuracy of pleural effusion and plasma samples versus tumour tissue for detection of EGFR mutation in patients with advanced non-small cell lung cancer: comparison of methodologies
Conclusions MPE and plasma are valid surrogates for NSCLC tumour EGFR mutation detection when tissue is not available. ARMS is most suitable for mutation detection in tissue and MPE cell blocks; however, mutant-specific IHC could be a complementary method when DNA-based molecular testing is unavailable. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - November 20, 2013 Category: Pathology Authors: Liu, X., Lu, Y., Zhu, G., Lei, Y., Zheng, L., Qin, H., Tang, C., Ellison, G., McCormack, R., Ji, Q. Tags: Open access, Lung cancer (oncology), Lung cancer (respiratory medicine) Original article Source Type: research
The lateral habenular nucleus mediates signal transduction from the insular cortex in OSA rats.
CONCLUSIONS: This study illustrates the mechanism by which an animal model of OSA is created by stimulating the Ic and promotes understanding of OSA pathogenesis. PMID: 24254575 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - November 20, 2013 Category: Sleep Medicine Authors: Wang J, Wang M, Wei Z, Li M, Huang M, Wang S Tags: Sleep Breath Source Type: research
Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I
In conclusion, mitochondrial topoisomerase I dampens mitochondrial transcription and thereby alters respiratory capacity. The mechanism involves selective association of the active enzyme with transcriptionally active nucleoids and a direct interaction with mitochondrial RNA polymerase. The inhibitory role of topoisomerase I in mitochondrial transcription is strikingly different from the stimulatory role of topoisomerase I in nuclear transcription. (Source: Nucleic Acids Research)
Source: Nucleic Acids Research - November 20, 2013 Category: Research Authors: Sobek, S., Dalla Rosa, I., Pommier, Y., Bornholz, B., Kalfalah, F., Zhang, H., Wiesner, R. J., von Kleist-Retzow, J.-C., Hillebrand, F., Schaal, H., Mielke, C., Christensen, M. O., Boege, F. Tags: Nucleic Acid Enzymes Source Type: research
The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury
Conclusions: The data indicates that exogenous surfactant did not mitigate ventilation-induced systemic inflammation in our models. Future studies will focus on altering surfactant composition to improve its immuno-modulating activity. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - November 20, 2013 Category: Respiratory Medicine Authors: Valeria PuntorieriJosh Qua HiansenLynda McCaigLi-Juan YaoRuud VeldhuizenJames Lewis Source Type: research
Serum heat shock protein 47 levels in patients with drug-induced lung disease
Conclusion: This study demonstrated that serum HSP47 levels were elevated in patients with DILD with a DAD pattern who had the worst outcomes among the different subgroups, and that this was correlated with P/F ratio and A-a DO2. (Source: Respiratory Research)
Source: Respiratory Research - November 20, 2013 Category: Respiratory Medicine Authors: Tomoyuki KakugawaShin-ichi YokotaYuji IshimatsuTomayoshi HayashiShota NakashimaShintaro HaraNoriho SakamotoYasuhiro MatsuokaHiroshi KubotaMariko MineHiroshi MukaeKazuhiro NagataShigeru Kohno Source Type: research
Respiratory mechanics and ventilatory control in overlap syndrome and obesity hypoventilation
Johan Verbraecken and Walter McNicholas review the major pathophysiological mechanisms believed to contribute to the development of overlap syndrome (coexistant COPD and obstructive sleep apnea) and obesity hypoventilation syndrome (OHS), which share common pathways. (Source: Respiratory Research)
Source: Respiratory Research - November 20, 2013 Category: Respiratory Medicine Authors: Johan VerbraeckenWalter McNicholas Source Type: research
Effect of sustained inflation versus step-wise PEEP strategy at birth on gas exchange and lung mechanics in preterm lambs.
Conclusions:An SEP at birth improved gas exchange, lung mechanics and EEV, without increasing lung injury, compared to the SI strategy used.Pediatric Research (2013); doi:10.1038/pr.2013.218. PMID: 24257321 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 20, 2013 Category: Pediatrics Authors: Tingay DG, Bhatia R, Schmölzer GM, Wallace MJ, Zahra VA, Davis PG Tags: Pediatr Res Source Type: research
OSAS affects liver histology and inflammatory cell activation in paediatric NAFLD, regardless of obesity/insulin resistance.
Conclusion. In paediatric NAFLD, OSAS is associated with biochemical, immunohistochemical and histological features of NASH and fibrosis. The impact of hypoxemia correction on liver disease severity warrants evaluation in future trials. PMID: 24256086 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 20, 2013 Category: Respiratory Medicine Authors: Nobili V, Cutrera R, Liccardo D, Pavone M, Devito R, Giorgio V, Verrillo E, Baviera G, Musso G Tags: Am J Respir Crit Care Med Source Type: research
Classification of Chronic Obstructive Pulmonary Disease Severity According to the New Global Initiative for Chronic Obstructive Lung Disease 2011 Guidelines: COPD Assessment Test Versus Modified Medical Research Council Scale.
CONCLUSIONS: The classification of patients with COPD using the assessment proposed by GOLD2011 varies according to the method used (CAT or mMRC); more than 25% of patients were reclassified into different categories, implying differences in the recommended therapeutic strategy. Longitudinal studies are needed to appraise which method better classifies patients, according to its prognostic ability. PMID: 24268434 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - November 20, 2013 Category: Respiratory Medicine Authors: Rieger-Reyes C, García-Tirado FJ, Rubio-Galán FJ, Marín-Trigo JM Tags: Arch Bronconeumol Source Type: research
Novel ABCA3 mutations as a cause of respiratory distress in a term newborn.
We report here the case of a term female newborn that developed severe respiratory distress soon after birth. She was found to be a compound heterozygote for both novel mutations in the ABCA3 gene. ABCA3 deficiency should be considered in mature babies who develop severe respiratory distress syndrome. PMID: 24269975 [PubMed - as supplied by publisher] (Source: Gene)
Source: Gene - November 20, 2013 Category: Genetics & Stem Cells Authors: Gonçalves JP, Pinheiro L, Costa M, Silva A, Gonçalves A, Pereira A Tags: Gene Source Type: research
Isolation and identification of bacteria capable of degrading euptox A from Eupatorium adenophorum Spreng.
Abstract Eupatorium adenophorum Spreng (E. adenophorum), an invasive plant which has caused widespread poisoning of livestock and crop failures in China. 9-oxo-10, 11-dehydroageraphorone (known as euptox A) is the main toxin causing a series of respiratory and digestive system diseases in animals. The purpose of the research is to isolate and identify the bacteria with the capacity of degrading euptox A, in which way could we lay the foundation in the utilization and prevention for E. adenophorum. Three strains of bacteria with the degradative characteristic are screened from E. adenophorum leaves, soil and goat's ...
Source: Toxicon - November 20, 2013 Category: Toxicology Authors: Liao F, Wang Y, Huang Y, Mo Q, Tan H, Wei Y, Hu Y Tags: Toxicon Source Type: research
Pharmacokinetic‐Pharmacodynamic Modeling in Anesthesia
Summary Anaesthesiologists adjust drug dosing, administration system and kind of drug to the characteristics of the patient. Then observe the expected response and adjust dosing to the specific requirements according to the difference between observed response, expected response and the context of the surgery and the patient. The approach above can be achieved because on one side quantification technology have made significant advances providing the anaesthesiologist to measure almost any effect by using noninvasive, continuous measuring systems. On the other because the knowledge on the relations between dosing, concentra...
Source: British Journal of Clinical Pharmacology - November 20, 2013 Category: Drugs & Pharmacology Authors: Pedro L. Gambús, Iñaki F. Trocóniz Tags: Review‐Themed Issue Source Type: research
Physicochemical and toxicological profiling of ash from the 2010 and 2011 eruptions of Eyjafjallajökull and Grímsvötn volcanoes, Iceland using a rapid respiratory hazard assessment protocol.
Abstract The six week eruption of Eyjafjallajökull volcano in 2010 produced heavy ash fall in a sparsely populated area of southern and south eastern Iceland and disrupted European commercial flights for at least 6 days. We adopted a protocol for the rapid analysis of volcanic ash particles, for the purpose of informing respiratory health risk assessments. Ash collected from deposits underwent a multi-laboratory physicochemical and toxicological investigation of their mineralogical parameters associated with bio-reactivity, and selected in vitro toxicology assays related to pulmonary inflammatory responses. Ash fr...
Source: Environmental Research - November 20, 2013 Category: Environmental Health Authors: Horwell CJ, Baxter PJ, Hillman SE, Calkins JA, Damby DE, Delmelle P, Donaldson K, Dunster C, Fubini B, Kelly FJ, Le Blond JS, Livi KJ, Murphy F, Nattrass C, Sweeney S, Tetley TD, Thordarson T, Tomatis M Tags: Environ Res Source Type: research
Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors.
Abstract To combat the public health threat from emerging coronaviruses (CoV), the development of antiviral therapies with either virus-specific or pan-CoV activities is necessary. An important step in antiviral drug development is the screening of potential inhibitors in cell-based systems. The recent emergence of the Middle East respiratory syndrome (MERS)-CoV necessitates adapting methods that have been used to identify antivirals against the severe, acute respiratory syndrome (SARS)-CoV and developing new approaches to more efficiently screen antiviral drugs. In this article we review cell-based assays using in...
Source: Antiviral Research - November 20, 2013 Category: Virology Authors: Kilianski A, Baker SC Tags: Antiviral Res Source Type: research
SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets.
Abstract The SARS (severe acute respiratory syndrome) pandemic caused ten years ago by the SARS-coronavirus (SARS-CoV) has stimulated a number of studies on the molecular biology of coronaviruses. This research has provided significant new insight into many mechanisms used by the coronavirus replicative-transcription complex (RTC). The RTC directs and coordinates processes in order to replicate and transcribe the coronavirus genome, a single-stranded, positive-sense RNA of outstanding length (∼27-32 kilobases). Here, we review the up-to-date knowledge on SARS-CoV replicative enzymes encoded in the ORF1b, i.e., th...
Source: Antiviral Research - November 20, 2013 Category: Virology Authors: Subissi L, Imbert I, Ferron F, Collet A, Coutard B, Decroly E, Canard B Tags: Antiviral Res Source Type: research
Identification of human metapneumovirus genotypes A and B from clinical specimens by reverse transcription loop-mediated isothermal amplification.
Abstract Human metapneumovirus (hMPV) has been recognized as an important pathogen for acute respiratory infections in children worldwide and classified into genotypes A and B. Reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay is a rapid diagnostic method for detecting nucleic acids with a single step under isothermal conditions in less than 1h. RT-LAMP targeting the M gene of hMPV was developed for detecting and identifying hMPV genotypes A and B. The detection limit of the genotype-specific hMPV RT-LAMP assay was 10 times greater than that of conventional reverse transcription polymeras...
Source: Journal of Virological Methods - November 20, 2013 Category: Virology Authors: Song Q, Zhu R, Sun Y, Zhao L, Wang F, Deng J, Qian Y Tags: J Virol Methods Source Type: research
Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures.
We report that MRCI-driven respiration and functional uncoupling (an inducible antioxidant mechanism) are reduced and levels of H2O2 are elevated in mitochondria isolated from KO mice. Experimental impairment of MRCI in WT hippocampal slices via rotenone reduces paired-pulse ratios (PPRs) at mossy fiber-CA3 synapses (resembling KO PPRs), and exacerbates seizure-like events in vitro. Daily treatment with AATP [a combination therapy composed of ascorbic acid (AA), alpha-tocopherol (T), sodium pyruvate (P) designed to synergistically target mitochondrial impairments] improved mitochondrial functions, mossy fiber PPRs, and red...
Source: Experimental Neurology - November 20, 2013 Category: Neurology Authors: Simeone KA, Matthews SA, Samson KK, Simeone TA Tags: Exp Neurol Source Type: research
Clinical use of pulse oximetry: Official guidelines from the Thoracic Society of Australia and New Zealand
Abstract Pulse oximetry provides a simple, non‐invasive approximation of arterial oxygenation in a wide variety of clinical settings including emergency and critical‐care medicine, hospital‐based and ambulatory care, perioperative monitoring, inpatient and outpatient settings, and for specific diagnostic applications. Pulse oximetry is of utility in perinatal, paediatric, adult and geriatric populations but may require use of age‐specific sensors in these groups. It plays a role in the monitoring and treatment of respiratory dysfunction by detecting hypoxaemia and is effective in guiding oxygen therapy in both adul...
Source: Respirology - November 20, 2013 Category: Respiratory Medicine Authors: Jeffrey J. Pretto, Teanau Roebuck, Lutz Beckert, Garun Hamilton Tags: Clinical Practice Guidelines Source Type: research
CYFRA 21‐1 as a disease severity marker for autoimmune pulmonary alveolar proteinosis
ConclusionsSerum CYFRA 21‐1 is a sensitive and useful serum marker for diagnosis and evaluation of disease severity of APAP, and may predict the response to GM‐CSF inhalation. (Source: Respirology)
Source: Respirology - November 20, 2013 Category: Respiratory Medicine Authors: Toru Arai, Yoshikazu Inoue, Chikatoshi Sugimoto, Yasushi Inoue, Keiko Nakao, Naoko Takeuchi, Akiko Matsumuro, Masaki Hirose, Koh Nakata, Seiji Hayashi Tags: Original Article Source Type: research
Pulmonary vascular limitation to exercise and survival in idiopathic pulmonary fibrosis
ConclusionsV'E/V'CO2, the only CPET parameter associated with elevated sPAP, appears a potentially useful non‐invasive marker for early detection of pulmonary vascular impairment, and therefore may be of use for a more accurate prognostic assessment in IPF patients. (Source: Respirology)
Source: Respirology - November 20, 2013 Category: Respiratory Medicine Authors: Mart N. Plas, Coen Kan, Judith Blumenthal, Henk M. Jansen, Athol U. Wells, Paul Bresser Tags: Original Article Source Type: research
Detection of viruses and atypical bacteria associated with acute respiratory infection of children in Hubei, China
ConclusionsThe most common pathogens causing acute respiratory infection among children in Hubei of China were mycoplasma pneumonia, influenza virus B and respiratory syncytial virus. The detection rates for each pathogen displayed specific seasonal and age group variations. (Source: Respirology)
Source: Respirology - November 20, 2013 Category: Respiratory Medicine Authors: Zegang Wu, Yan Li, Jian Gu, Hongyun Zheng, Yongqing Tong, Qing Wu Tags: Original Article Source Type: research
The effects of a peer modeling intervention on cardiorespiratory fitness parameters and self-efficacy in obese adolescents.
This study examined the effect of a peer modeling intervention on cardiorespiratory fitness performance and task self-efficacy in obese youth completing a maximal treadmill test. Forty-nine obese (BMI ≥ 95th percentile for age and sex) youth were randomized to an experimental (received an intervention) or to a control group. The outcome variables were mean and variability cardiorespiratory fitness (peak VO2, heart rate, duration, respiratory exchange ratio), rating of perceived exertion, and task self-efficacy scores. Irrespective of whether a mean or variability score was used, receiving the intervention was associated ...
Source: Behavioral Medicine - November 19, 2013 Category: Psychiatry Authors: De Jesus S, Prapavessis H Tags: Behav Med Source Type: research
Perioperative Organ Injury
Despite the fact that a surgical procedure may have been performed for the appropriate indication and in a technically perfect manner, patients are threatened by perioperative organ injury. For example, stroke, myocardial infarction, acute respiratory distress syndrome, acute kidney injury, or acute gut injury are among the most common causes for morbidity and mortality in surgical patients. In the current review, the authors discuss the pathogenesis of perioperative organ injury, and provide select examples for novel treatment concepts that have emerged over the past decade. Indeed, the authors are of the opinion that res...
Source: Anesthesiology - November 19, 2013 Category: Anesthesiology Tags: Education: Review Article Source Type: research
Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes
Di Pierro F, Putignano P, Villanova N, Montesi L, Moscatiello S, Marchesini G (Source: International Journal of COPD)
Source: International Journal of COPD - November 19, 2013 Category: Respiratory Medicine Source Type: research