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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury
Paxillin is phosphorylated at multiple residues; however, the role of tyrosine phosphorylation of paxillin in endothelial barrier dysfunction and acute lung injury (ALI) remains unclear. We used siRNA and site-specific nonphosphorylable mutants of paxillin to abrogate the function of paxillin to determine its role in lung endothelial permeability and ALI. In vitro, lipopolysaccharide (LPS) challenge of human lung microvascular endothelial cells (HLMVECs) resulted in enhanced tyrosine phosphorylation of paxillin at Y31 and Y118 with no significant change in Y181 and significant barrier dysfunction. Knockdown of paxillin wit...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2015 Category: Respiratory Medicine Authors: Fu, P., Usatyuk, P. V., Lele, A., Harijith, A., Gregorio, C. C., Garcia, J. G. N., Salgia, R., Natarajan, V. Tags: CALL FOR PAPERS Source Type: research

Evaluation of cigarette smoke-induced emphysema in mice using quantitative micro-computed tomography
Chronic cigarette smoke (CS) exposure provokes variable changes in the lungs, and emphysema is an important feature of chronic obstructive pulmonary disease. The usefulness of micro-computed tomography (CT) to assess emphysema in different mouse models has been investigated, but few studies evaluated the dynamic structural changes in a CS-induced emphysema mouse model. A novel micro-CT technique with respiratory and cardiac gating has resulted in high-quality images that enable processing for further quantitative and qualitative analyses. Adult female C57BL/6J mice were repeatedly exposed to mainstream CS, and micro-CT sca...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2015 Category: Respiratory Medicine Authors: Sasaki, M., Chubachi, S., Kameyama, N., Sato, M., Haraguchi, M., Miyazaki, M., Takahashi, S., Betsuyaku, T. Tags: CALL FOR PAPERS Source Type: research

Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension
Endothelial cell (EC) dysfunction plays a role in the pathobiology of occlusive vasculopathy in pulmonary arterial hypertension (PAH). Purinergic signaling pathways, which consist of extracellular nucleotide and nucleoside-mediated cell signaling through specific receptors, are known to be important regulators of vascular tone and remodeling. Therefore, we hypothesized that abnormalities in the vascular purinergic microenvironment are associated with PAH. Enzymatic clearance is crucial to terminate unnecessary cell activation; one of the most abundantly expressed enzymes on the EC surface is E-NTPDase1/CD39, which hydrolyz...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2015 Category: Respiratory Medicine Authors: Helenius, M. H., Vattulainen, S., Orcholski, M., Aho, J., Komulainen, A., Taimen, P., Wang, L., de Jesus Perez, V. A., Koskenvuo, J. W., Alastalo, T.-P. Tags: ARTICLES Source Type: research

Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages
Inflammasomes are cytosolic protein complexes that promote the cleavage of caspase-1, which leads to the maturation and secretion of proinflammatory cytokines, including interleukin-1β (IL-1β) and IL-18. Among the known inflammasomes, the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3)-dependent inflammasome is critically involved in the pathogenesis of various acute or chronic inflammatory diseases. Carbon monoxide (CO), a gaseous molecule physiologically produced in cells and tissues during heme catabolism, can act as an anti-inflammatory molecule and a potent negati...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2015 Category: Respiratory Medicine Authors: Jung, S.-S., Moon, J.-S., Xu, J.-F., Ifedigbo, E., Ryter, S. W., Choi, A. M. K., Nakahira, K. Tags: ARTICLES Source Type: research

Roflumilast combined with adenosine increases mucosal hydration in human airway epithelial cultures after cigarette smoke exposure
Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality worldwide. Recent studies have shown that cigarette smoke (CS) induces cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction, which leads to airway-surface liquid (ASL) dehydration. This in turn contributes to the mucus dehydration and impaired mucociliary clearance that are seen in the chronic bronchitis form of COPD. Roflumilast is a phosphodiesterase 4 inhibitor that may improve lung function and reduce the frequency of exacerbations in patients with COPD. Although roflumilast can affect cAMP metabolism, little is...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2015 Category: Respiratory Medicine Authors: Tyrrell, J., Qian, X., Freire, J., Tarran, R. Tags: ARTICLES Source Type: research

Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs
Fragments of the mitochondrial genome released into the systemic circulation after mechanical trauma, termed mitochondrial DNA damage-associated molecular patterns (mtDNA DAMPs), are thought to mediate the systemic inflammatory response syndrome. The close association between circulating mtDNA DAMP levels and outcome in sepsis suggests that bacteria also might be a stimulus for mtDNA DAMP release. To test this hypothesis, we measured mtDNA DAMP abundance in medium perfusing isolated rat lungs challenged with an intratracheal instillation of 5 x 107 colony-forming units of Pseudomonas aeruginosa (strain 103; PA103). Intratr...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2015 Category: Respiratory Medicine Authors: Kuck, J. L., Obiako, B. O., Gorodnya, O. M., Pastukh, V. M., Kua, J., Simmons, J. D., Gillespie, M. N. Tags: ARTICLES Source Type: research

Nrf2 regulates PU.1 expression and activity in the alveolar macrophage
Alveolar macrophage (AM) immune function depends on the activation of the transcription factor PU.1 by granulocyte macrophage colony-stimulating factor. We have determined that chronic alcohol ingestion dampens PU.1 signaling via an unknown zinc-dependent mechanism; specifically, although PU.1 is not known to be a zinc-dependent transcription factor, zinc treatment reversed alcohol-mediated dampening of PU.1 signaling. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a zinc-dependent basic leucine zipper protein essential for antioxidant defenses, is also impaired by chronic alcohol ingestion and enhanced by zinc treatm...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2015 Category: Respiratory Medicine Authors: Staitieh, B. S., Fan, X., Neveu, W., Guidot, D. M. Tags: ARTICLES Source Type: research

Body mass index, respiratory conditions, asthma, and chronic obstructive pulmonary disease
This study aims to assess the relationship of body mass index (BMI) status with respiratory conditions, asthma, and chronic obstructive pulmonary disease (COPD) in a state population. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 15, 2015 Category: Respiratory Medicine Authors: Yong Liu, Roy A. Pleasants, Janet B. Croft, Njira Lugogo, Jill Ohar, Khosrow Heidari, Charlie Strange, Anne G. Wheaton, David M. Mannino, Monica Kraft Source Type: research

Vaccine coverage in CF children: A French multicenter study
Recent reports have pointed the low vaccine coverage in patients with chronic diseases. Data are lacking in patients with cystic fibrosis (CF). Gaining more information on coverage both for mandatory vaccines and those more specifically recommended would help to optimize care of these patients. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - May 15, 2015 Category: Respiratory Medicine Authors: A. Masson, O. Launay, B. Delaisi, L. Bassinet, N. Remus, M. Lebourgeois, F. Chedevergne, C. Bailly, P. Foucaud, H. Corvol, J. deBlic, I. Sermet-Gaudelus Tags: Original Article Source Type: research

Cardiac ECMO: How to predict the unpredictable
Extracorporeal Membrane Oxygenation (ECMO) has long been considered standard of care for babies and children with severe cardiac and respiratory failure. In recent years, there has been a substantial increase in utilization of ECMO for adult patients.[1] The CESAR trail demonstrated efficacy of ECMO for acute respiratory failure[2], and experience with H1N1 influenza suggested enhanced survival for patients with severe disease that were referred for ECMO. [3,4] Likewise, there has been growing enthusiasm for ECMO in adult cardiac failure resulting from myocardial infarction, myocarditis, or postcardiotomy shock. (Source: J...
Source: Journal of Surgical Research - May 15, 2015 Category: Surgery Authors: Jonathan W. Haft Source Type: research

Endothelial disruptive pro-inflammatory effects of nicotine and e-cigarette vapor exposures.
Abstract The increased use of inhaled nicotine via e-cigarettes has unknown risks to lung health. Having previously shown that cigarette smoke (CS) extract disrupts the lung microvasculature barrier function by endothelial cell activation and cytoskeletal rearrangement, we investigated the contribution of nicotine in CS or e-cigarette extracts (e-Cig) to lung endothelial injury. Primary lung microvascular endothelial cells were exposed to nicotine, e-Cig solution, or condensed e-Cig vapor (1-20 mM nicotine) or to nicotine-free CS extract or e-Cig solutions. Compared to nicotine-containing, nicotine free-CS extract ...
Source: Am J Physiol Lung Ce... - May 15, 2015 Category: Respiratory Medicine Authors: Schweitzer KS, Chen SX, Law S, Van Demark MJ, Poirier C, Justice MJ, Hubbard WC, Kim ES, Lai X, Wang M, Kranz WD, Carroll CJ, Ray BD, Bittman R, Goodpaster J, Petrache I Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Elevated sputum BPIFB1 levels in smokers with chronic obstructive pulmonary disease: a longitudinal study.
In conclusion, higher sputum concentrations of BPIFB1 were associated with changes of lung function over time, especially in current smokers with COPD. BPIFB1 may be involved in the pathogenesis of smoking-related lung diseases. PMID: 25979078 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - May 15, 2015 Category: Respiratory Medicine Authors: Gao J, Ohlmeier S, Nieminen P, Toljamo T, Tiitinen S, Kanerva T, Bingle L, Araujo B, Rönty M, Höyhtyä M, Bingle CD, Mazur W, Pulkkinen V Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Contribution of srf, elk-1 and myocardin to airway smooth muscle remodeling in heaves, an asthma-like disease of horses.
In conclusion, SRF and its cofactor MYOCD likely contribute to the hypertrophy of peripheral ASM observed in equine asthmatic airways, while the remodeling of the central airways is more static or involves different transcription factors. PMID: 25979077 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - May 15, 2015 Category: Respiratory Medicine Authors: Chevigny M, Guérin-Montpetit K, Vargas A, Lefebvre-Lavoie J, Lavoie JP Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Continuous Mucociliary Transport by Primary Human Airway Epithelial Cells in vitro.
In this study, we have characterized a novel method that allows human airway epithelial cells to differentiate into a mucociliary epithelium that transports mucus in a continuous circular track. The mucociliary transport device (MCTD) allows the measurement and manipulation of all features of mucociliary transport (MCT) in a controlled in vitro system. In this initial study, the effect of ciliary beat frequency and mucus concentration on the speed of mucociliary transport was investigated. PMID: 25979076 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - May 15, 2015 Category: Respiratory Medicine Authors: Sears PR, Yin WN, Ostrowski LE Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Erratum: Daily Rifapentine for Treatment of Pulmonary Tuberculosis: A Randomized, Dose-Ranging Trial.
Authors: PMID: 25978581 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Erratum: Bioactive Lipids in Emphysema: Decoding Fat to Reveal COPD Phenotypes.
Authors: PMID: 25978580 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Reply: Lung Cancer Screening: The Balance between Harm and Benefit.
PMID: 25978579 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Tanoue LT, Tanner NT, Gould MK, Silvestri GA Tags: Am J Respir Crit Care Med Source Type: research

Lung Cancer Screening: The Balance between Harm and Benefit.
PMID: 25978578 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Zulueta JJ, de-Torres JP Tags: Am J Respir Crit Care Med Source Type: research

Reply: Reduction of Airway Smooth Muscle Mass by Bronchial Thermoplasty in Patients with Severe Asthma.
PMID: 25978577 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Aubier M, Pretolani M, Chanez P, Thabut G, Debray MP, Taille C, Knap D, Hamidi F Tags: Am J Respir Crit Care Med Source Type: research

Reduction of Airway Smooth Muscle Mass after Bronchial Thermoplasty: Are We There Yet?
PMID: 25978576 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Bonta PI, d'Hooghe J, Sterk PJ, Bel EH, Annema JT Tags: Am J Respir Crit Care Med Source Type: research

Circulating Levels of Antioxidant Vitamins Correlate with Better Lung Function and Reduced Exposure to Ambient Pollution.
PMID: 25978575 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Menni C, Metrustry SJ, Mohney RP, Beevers S, Barratt B, Spector TD, Kelly FJ, Valdes AM Tags: Am J Respir Crit Care Med Source Type: research

Sustained Benefit of Community-based Tuberculosis Interventions after 30 Years.
PMID: 25978574 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Accinelli RA, Romero LR, García RF, Sánchez R Tags: Am J Respir Crit Care Med Source Type: research

Co-occurrence of Pneumoperitoneum and Pneumothorax in a Patient with Pleuroparenchymal Fibroelastosis.
PMID: 25978573 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Kusagaya H, Fujisawa T, Enomoto N, Inui N, Nakamura Y, Suda T Tags: Am J Respir Crit Care Med Source Type: research

Chlorhexidine Bathing Impact on Infections, Effect of Etomidate on Sepsis Mortality, and Evaluation of Ventilator-associated Conditions.
PMID: 25978572 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Sasieta HC, Foley F, Batzlaff CM Tags: Am J Respir Crit Care Med Source Type: research

Toward Resolving the Paradox of the Critical Role of the DosR Regulon in Mycobacterium tuberculosis Persistence and Active Disease.
PMID: 25978571 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Voskuil MI, Schlesinger LS Tags: Am J Respir Crit Care Med Source Type: research

IFN-γ Release Assays for Risk Assessment in Contacts of Patients with Tuberculosis in Low-Burden European Countries.
PMID: 25978570 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Zumla A, Maeurer M Tags: Am J Respir Crit Care Med Source Type: research

Screening for Lung Cancer Using Low-Dose Computed Tomography. Are We Headed for DANTE's Paradise or Inferno?
PMID: 25978569 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Tanner NT, Silvestri GA Tags: Am J Respir Crit Care Med Source Type: research

Personalizing Medicine. Quantification of Cystic Fibrosis Using Computed Tomography.
PMID: 25978568 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: van Beek EJ Tags: Am J Respir Crit Care Med Source Type: research

Understanding the Global Burden of Pediatric Sepsis.
PMID: 25978567 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Marshall JC Tags: Am J Respir Crit Care Med Source Type: research

Muscle Weakness in Critical Illness.
PMID: 25978566 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Sieck GC Tags: Am J Respir Crit Care Med Source Type: research

Targeting 'types: Precision Medicine in Pulmonary Disease.
PMID: 25978565 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 15, 2015 Category: Respiratory Medicine Authors: Steiling K, Christenson SA Tags: Am J Respir Crit Care Med Source Type: research