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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

How common is the lipid body-containing interstitial cell in the mammalian lung?
Pulmonary lipofibroblasts are thought to be involved in lung development, regeneration, vitamin A storage, and surfactant synthesis. Most of the evidence for these important functions relies on mouse or rat studies. Therefore, the present study was designed to investigate the presence of lipofibroblasts in a variety of early postnatal and adult mammalian species (including humans) to evaluate the ability to generalize functions of this cell type for other species. For this purpose, lung samples from 14 adult mammalian species as well as from postnatal mice, rats, and humans were investigated using light and electron micros...
Source: AJP: Lung Cellular and Molecular Physiology - September 1, 2014 Category: Respiratory Medicine Authors: Tahedl, D., Wirkes, A., Tschanz, S. A., Ochs, M., Muhlfeld, C. Tags: ARTICLES Source Type: research

Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy
We report that influenza induces marked, long-lasting dysfunction of the alveolar-capillary barrier peaking at 1 wk but lasting longer than 3 wk postinfection. Weight loss, commonly employed as a criterion for euthanasia (and hence "survival"), was found to be poorly predictive of the severity of lung injury at its peak; rather, persistent weight loss 11 days postinfection identified mice with impaired injury resolution. Murine and human bone marrow-derived MSCs (obtained from the National Institutes of Health repository) were then administered intravenously during the rapid phase of injury progression. Murine MSCs (mMSCs)...
Source: AJP: Lung Cellular and Molecular Physiology - September 1, 2014 Category: Respiratory Medicine Authors: Gotts, J. E., Abbott, J., Matthay, M. A. Tags: ARTICLES Source Type: research

Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells
Bile acids resulting from the aspiration of gastroesophageal refluxate are often present in the lower airways of people with cystic fibrosis and other respiratory distress diseases. Surprisingly, there is little or no information on the modulation of airway epithelial ion transport by bile acids. The secretory effect of a variety of conjugated and unconjugated secondary bile acids was investigated in Calu-3 airway epithelial cells grown under an air-liquid interface and mounted in Ussing chambers. Electrogenic transepithelial ion transport was measured as short-circuit current (Isc). The taurine-conjugated secondary bile a...
Source: AJP: Lung Cellular and Molecular Physiology - September 1, 2014 Category: Respiratory Medicine Authors: Hendrick, S. M., Mroz, M. S., Greene, C. M., Keely, S. J., Harvey, B. J. Tags: ARTICLES Source Type: research

Chronic hypoxia limits H2O2-induced inhibition of ASIC1-dependent store-operated calcium entry in pulmonary arterial smooth muscle
Our laboratory shows that acid-sensing ion channel 1 (ASIC1) contributes to the development of hypoxic pulmonary hypertension by augmenting store-operated Ca2+ entry (SOCE) that is associated with enhanced agonist-induced vasoconstriction and arterial remodeling. However, this enhanced Ca2+ influx following chronic hypoxia (CH) is not dependent on an increased ASIC1 protein expression in pulmonary arterial smooth muscle cells (PASMC). It is well documented that hypoxic pulmonary hypertension is associated with changes in redox potential and reactive oxygen species homeostasis. ASIC1 is a redox-sensitive channel showing inc...
Source: AJP: Lung Cellular and Molecular Physiology - September 1, 2014 Category: Respiratory Medicine Authors: Plomaritas, D. R., Herbert, L. M., Yellowhair, T. R., Resta, T. C., Gonzalez Bosc, L. V., Walker, B. R., Jernigan, N. L. Tags: ARTICLES Source Type: research

Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis
Conclusions: The pathological findings in patients with AE-IPF represent not only DAD, but also a variety of pathological conditions. Therefore, making a diagnosis of AE-IPF is often difficult, and the use of cautious diagnostic approaches is required for appropriate treatment. (Source: Respiratory Research)
Source: Respiratory Research - September 1, 2014 Category: Respiratory Medicine Authors: Keishi OdaHiroshi IshimotoSohsuke YamadaHisako KushimaHiroshi IshiiTomotoshi ImanagaTatsuhiko HaradaYuji IshimatsuNobuhiro MatsumotoKeisuke NaitoKazuhiro YateraMasamitsu NakazatoJun-ichi KadotaKentaro WatanabeShigeru KohnoHiroshi Mukae Source Type: research

Rectus sheath hematoma with low molecular weight heparin administration: a case series
Conclusion: We believe this reflects an underreported significant cause of morbidity and mortality with low molecular weight heparin administration. We review the pathophysiology of rectus sheath hematoma as well as its presentation, diagnosis, and treatment. We identify at-risk populations and proposed contributing factors. We also discuss factors leading to underreporting as well as preventive strategies implemented at our institution. (Source: BMC Research Notes)
Source: BMC Research Notes - September 1, 2014 Category: Research Authors: Laura SullivanDale WorthamKayleigh Litton Source Type: research

Intrafetal glucose infusion alters glucocorticoid signaling and reduces surfactant protein mRNA expression in the lung of the late-gestation sheep fetus
In this study, we examined the effect of intrafetal glucose infusion on mRNA expression of glucose transporters, insulin-like growth factor signaling, glucocorticoid regulatory genes, and surfactant proteins in the lung of the late-gestation sheep fetus. The numerical density of the cells responsible for producing surfactant was determined using immunohistochemistry. Glucose infusion for 10 days did not affect mRNA expression of glucose transporters or IGFs but did decrease IGF-1R expression. There was reduced mRNA expression of the glucocorticoid-converting enzyme HSD11B-1 and the glucocorticoid receptor, potentially redu...
Source: AJP: Regulatory, Integrative and Comparative Physiology - September 1, 2014 Category: Physiology Authors: McGillick, E. V., Morrison, J. L., McMillen, I. C., Orgeig, S. Tags: Respiration Source Type: research

Surface tension in situ in flooded alveolus unaltered by albumin
In the acute respiratory distress syndrome, plasma proteins in alveolar edema liquid are thought to inactivate lung surfactant and raise surface tension, T. However, plasma protein-surfactant interaction has been assessed only in vitro, during unphysiologically large surface area compression (%A). Here, we investigate whether plasma proteins raise T in situ in the isolated rat lung under physiologic conditions. We flood alveoli with liquid that omits/includes plasma proteins. We ventilate the lung between transpulmonary pressures of 5 and 15 cmH2O to apply a near-maximal physiologic %A, comparable to that of severe mechani...
Source: Journal of Applied Physiology - September 1, 2014 Category: Physiology Authors: Kharge, A. B., Wu, Y., Perlman, C. E. Tags: ARTICLES Source Type: research

Heat stress protects against mechanical ventilation-induced diaphragmatic atrophy
Mechanical ventilation (MV) is a life-saving intervention in patients who are incapable of maintaining adequate pulmonary gas exchange due to respiratory failure or other disorders. However, prolonged MV is associated with the development of respiratory muscle weakness. We hypothesized that a single exposure to whole body heat stress would increase diaphragm expression of heat shock protein 72 (HSP72) and that this treatment would protect against MV-induced diaphragmatic atrophy. Adult male Wistar rats (n = 38) were randomly assigned to one of four groups: an acutely anesthetized control group (CON) with no MV; 12-h contro...
Source: Journal of Applied Physiology - September 1, 2014 Category: Physiology Authors: Ichinoseki-Sekine, N., Yoshihara, T., Kakigi, R., Sugiura, T., Powers, S. K., Naito, H. Tags: ARTICLES Source Type: research

A novel ultrasound technique to measure genioglossus movement in vivo
This study aimed to develop a novel ultrasound (US) method to measure GG movement in real time. We tested 20 healthy, awake subjects (21–38 yr) breathing quietly in the supine posture with the head in a neutral position. US images were collected using a transducer positioned submentally. Image correlation analysis measured regional displacement of GG within a grid of points in the midsagittal plane throughout the respiratory cycle. Typically, motion began before inspiratory flow in an anteroinferior direction and peaked in midinspiration. Average peak displacements of the anterior, posterior, superior, and inferior g...
Source: Journal of Applied Physiology - September 1, 2014 Category: Physiology Authors: Kwan, B. C. H., Butler, J. E., Hudson, A. L., McKenzie, D. K., Bilston, L. E., Gandevia, S. C. Tags: INNOVATIVE METHODOLOGY Source Type: research

Adaptive and innate immune responses in a rat orthotopic lung transplant model of chronic lung allograft dysfunction
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - September 1, 2014 Category: Transplant Surgery Authors: Alena Evers, Srebrena Atanasova, Gabriele Fuchs‐Moll, Kathrin Petri, Sigrid Wilker, Anna Zakrzewicz, Markus Hirschburger, Winfried Padberg, Veronika Grau Tags: Original Article Source Type: research

Clinical Reasoning: A 52-year-old woman with progressive proximal weakness
A 52-year-old woman presented with a 12-year history of progressive limb weakness. She first had trouble climbing stairs and later difficulty getting up from a chair. She also experienced hip and shoulder pain. Over the previous 2 years, combing her hair became difficult. She denied any eyelid drooping, double vision, chewing or swallowing difficulty, slurred speech, shortness of breath, numbness, tingling, autonomic symptoms, or cognitive problems. She did not have any rashes or joint pain. She had no other medical problems and was not taking any medications. She was born full-term and had normal developmental milestones....
Source: Neurology - September 1, 2014 Category: Neurology Authors: Enduri, S., Taylor, M. R. G., Liewluck, T. Tags: Muscle disease RESIDENT AND FELLOW SECTION Source Type: research

Timing and number of minor infections as risk factors for childhood arterial ischemic stroke
Conclusions: Minor infections appear to have a strong but short-lived effect on pediatric stroke risk, while cumulative burden of infection had no effect. Proposed mechanisms for the link between minor infection and stroke in adults include an inflammatory-mediated prothrombotic state and chronic endothelial injury. The transient effect of infection in children may suggest a greater role for a prothrombotic mechanism. (Source: Neurology)
Source: Neurology - September 1, 2014 Category: Neurology Authors: Hills, N. K., Sidney, S., Fullerton, H. J. Tags: Childhood stroke, All Infections, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke, Case control studies ARTICLE Source Type: research

The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence
Nearly all bacteria exhibit a type of phenotypic growth described as persistence that is thought to underlie antibiotic tolerance and recalcitrant chronic infections. The chromosomally encoded high-persistence (Hip) toxin–antitoxin proteins HipASO and HipBSO from Shewanella oneidensis, a proteobacterium with unusual respiratory capacities, constitute a type II toxin–antitoxin protein module. Here we show that phosphorylated HipASO can engage in an unexpected ternary complex with HipBSO and double-stranded operator DNA that is distinct from the prototypical counterpart complex from Escherichia coli. The structur...
Source: Nucleic Acids Research - September 1, 2014 Category: Research Authors: Wen, Y., Behiels, E., Felix, J., Elegheert, J., Vergauwen, B., Devreese, B., Savvides, S. N. Tags: Structural Biology Source Type: research

Duration of Daycare Attendance During Infancy Predicts Asthma at Age Seven: The Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)
ConclusionDepending on duration of attendance, daycare during infancy can either increase or reduce risk of asthma at age 7.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - September 1, 2014 Category: Allergy & Immunology Authors: Gang Cheng, Andrew M. Smith, Linda Levin, Tolly Epstein, Patrick H. Ryan, Grace K LeMasters, Gurjit K. Khurana Hershey, Tina Reponen, Manuel Villareal, Jim Lockey, David I. Bernstein Tags: Original Article‐Epidemiology of Allergic Disease Source Type: research

Sparing surgery with the use of tini‐based endografts in larynx cancer patients
ConclusionThe technique allowed to achieve well oncological (the 5‐year and overall recurrence‐free survival rates of all 120 patients were 83% and 76%, respectively) and functional (larynx function was saved in 93% of cases) outcomes after extensive and subtotal resections in patients with locally distributed larynx cancer. J. Surg. Oncol. © 2014 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - September 1, 2014 Category: Cancer & Oncology Authors: Marat Muhamedov, Denis Kulbakin, Victor Gunther, Evgeniy Choynzonov, Timofey Chekalkin, Valentina Hodorenko Tags: Research Article Source Type: research

Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis
Conclusions: The pathological findings in patients with AE-IPF represent not only DAD, but also a variety of pathological conditions. Therefore, making a diagnosis of AE-IPF is often difficult, and the use of cautious diagnostic approaches is required for appropriate treatment. (Source: Respiratory Research)
Source: Respiratory Research - September 1, 2014 Category: Respiratory Medicine Authors: Keishi OdaHiroshi IshimotoSohsuke YamadaHisako KushimaHiroshi IshiiTomotoshi ImanagaTatsuhiko HaradaYuji IshimatsuNobuhiro MatsumotoKeisuke NaitoKazuhiro YateraMasamitsu NakazatoJun-ichi KadotaKentaro WatanabeShigeru KohnoHiroshi Mukae Source Type: research

Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis.
CONCLUSION: This is the first report that exploits next-generation sequencing to determine local and peripheral blood IGH repertoires in patients with respiratory allergic disease. We demonstrate that natural pollen exposure was associated with changes in IgE repertoires that were suggestive of ongoing germinal center reactions. Furthermore, these changes were more often apparent in nasal biopsy specimens compared with peripheral blood and in patients with AR compared with healthy control subjects. PMID: 25171866 [PubMed - in process] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - September 1, 2014 Category: Cancer & Oncology Authors: Wu YC, James LK, Vander Heiden JA, Uduman M, Durham SR, Kleinstein SH, Kipling D, Gould HJ Tags: J Allergy Clin Immunol Source Type: research

Lung function at 6 and 18 months after preterm birth in relation to severity of bronchopulmonary dysplasia
ConclusionsIn the present study BPD severity did not predict lung function, but may be associated with impaired alveolarization, indicated by reduced Cso. Respiratory morbidity was associated with reduced airway function and respiratory compliance in infancy after preterm birth. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - September 1, 2014 Category: Respiratory Medicine Authors: Per Thunqvist, Per Gustafsson, Mikael Norman, Magnus Wickman, Jenny Hallberg Tags: Original Article: Neonatal Lung Disease Source Type: research

Predictors of agitation in critically ill adults.
CONCLUSIONS: Predictors of agitation on admission and within 24 hours before the onset of agitation were primarily clinical variables. PMID: 25179037 [PubMed - in process] (Source: American Journal of Critical Care)
Source: American Journal of Critical Care - September 1, 2014 Category: Nursing Authors: Burk RS, Grap MJ, Munro CL, Schubert CM, Sessler CN Tags: Am J Crit Care Source Type: research

Discharge outcome in adults treated with extracorporeal membrane oxygenation.
CONCLUSIONS: Patients with respiratory indications for ECMO experienced better survival than did cardiac patients. Increasing age was associated with poor outcome. Complications, regardless of ECMO indication, were common and associated with poor outcome. PMID: 25179031 [PubMed - in process] (Source: American Journal of Critical Care)
Source: American Journal of Critical Care - September 1, 2014 Category: Nursing Authors: Guttendorf J, Boujoukos AJ, Ren D, Rosenzweig MQ, Hravnak M Tags: Am J Crit Care Source Type: research

Subjective ratings of prolonged inspiratory resistive loaded breathing in males and females
Abstract Dyspnea and fear of suffocation are burdensome to patients with respiratory disease. Inspiratory resistive loads offer an experimental respiratory stimulus to quantify the discriminative domain of respiratory perception. Resistive (R) load magnitude estimation (ME) and subjective ratings were measured over sustained multiple breaths in healthy subjects. There was no significant group difference between the ME for Breath 1 and 20 for small R loads, but a significant gender difference for large R loads. Subjective responses of fear, fear of suffocation, displeasure, chest pressure, faintness, dizziness, fear of losi...
Source: Psychophysiology - September 1, 2014 Category: Neurology Authors: Sarah Miller, Paul W. Davenport Tags: Original Article Source Type: research

Extracorporeal support for patients with acute respiratory distress syndrome.
Abstract Extracorporeal membrane oxygen (ECMO) has been used for many years in patients with life-threatening hypoxaemia and/or hypercarbia. While early trials demonstrated that it was associated with poor outcomes and extensive haemorrhage, the technique has evolved. It now encompasses new technologies and understanding that the lung protective mechanical ventilation it can facilitate is inextricably linked to improving outcomes for patients. The positive results from the CESAR (Conventional ventilation or ECMO for Severe Adult Respiratory failure) study and excellent outcomes in patients who suffered severe influ...
Source: Respiratory Care - September 1, 2014 Category: Respiratory Medicine Authors: Finney SJ Tags: Eur Respir Rev Source Type: research

The vascular bed in COPD: pulmonary hypertension and pulmonary vascular alterations.
Abstract The loss of pulmonary vessels has been shown to be related to the severity of pulmonary hypertension in patients with chronic obstructive pulmonary disease (COPD). The severity of hypoxaemia is also related to pulmonary hypertension and pulmonary vascular resistance in these patients, suggesting that the hypoxic condition probably plays an important role in this form of pulmonary hypertension. However, pulmonary hypertension also develops in patients with mild COPD without hypoxaemia. Oxygen supplementation therapy often fails to reverse the pulmonary hypertension in these COPD patients, thus suggesting th...
Source: Respiratory Care - September 1, 2014 Category: Respiratory Medicine Authors: Sakao S, Voelkel NF, Tatsumi K Tags: Eur Respir Rev Source Type: research

Depression and anxiety in patients with COPD.
Abstract Under-recognised and untreated depression and anxiety symptoms have deleterious effects on physical functioning and social interaction increasing fatigue and healthcare utilisation in patients with chronic obstructive pulmonary disease (COPD). Depression and anxiety are challenging to identify and treat because their symptoms often overlap with those of COPD. The cause(s) of depression and anxiety symptoms are multifactorial and include behavioural, social and biological factors. Less than one-third of COPD patients with comorbid depression or anxiety symptoms are receiving appropriate treatment. Factors t...
Source: Respiratory Care - September 1, 2014 Category: Respiratory Medicine Authors: Yohannes AM, Alexopoulos GS Tags: Eur Respir Rev Source Type: research

Addressing unmet needs in the treatment of COPD.
Abstract The burden of chronic obstructive pulmonary disease (COPD) is considerable, both socially and economically. Central to COPD management is the use of long-acting bronchodilators, which provide patients with optimal bronchodilation and improvements in symptoms. The once-daily, long-acting β2-agonist indacaterol, the long-acting muscarinic antagonist glycopyrronium, and the indacaterol/glycopyrronium fixed-dose combination QVA149 have all been shown to significantly improve lung function and patient-reported outcomes. The ability to take medication appropriately is important. Easy to use, low resistance devi...
Source: Respiratory Care - September 1, 2014 Category: Respiratory Medicine Authors: Patalano F, Banerji D, D'Andrea P, Fogel R, Altman P, Colthorpe P Tags: Eur Respir Rev Source Type: research

Defining a training framework for clinicians in respiratory critical care.
PMID: 25176951 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - September 1, 2014 Category: Respiratory Medicine Authors: Artigas A, Noël JL, Brochard L, Busari JO, Dellweg D, Ferrer M, Geiseler J, Larsson A, Nava S, Navalesi P, Orfanos S, Palange P, Pelosi P, Rohde G, Schoenhofer B, Vassilakopoulos T, Simonds AK Tags: Eur Respir J Source Type: research

Irritants and asthma.
PMID: 25176947 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - September 1, 2014 Category: Respiratory Medicine Authors: Casas L, Nemery B Tags: Eur Respir J Source Type: research

Effects of short- and long-term exposures to ambient air pollution on COPD.
PMID: 25176946 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - September 1, 2014 Category: Respiratory Medicine Authors: Garshick E Tags: Eur Respir J Source Type: research

Ageing and multimorbidity.
PMID: 25176945 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - September 1, 2014 Category: Respiratory Medicine Authors: Drazen JM, Fabbri LM Tags: Eur Respir J Source Type: research

Lung function in adult survivors of very low birth weight, with and without bronchopulmonary dysplasia
ConclusionsVLBW survivors continue to have airways obstruction in their mid‐20s compared with controls, particularly those who had BPD in the newborn period. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - September 1, 2014 Category: Respiratory Medicine Authors: Anne‐Marie Gibson, Charlotte Reddington, Lucy McBride, Catherine Callanan, Colin Robertson, Lex W Doyle Tags: Original Article: Neonatal Lung Disease Source Type: research

IgE Sensitization to Aspergillus fumigatus Is Not a Bystander Phenomenon in Cystic Fibrosis Lung Disease.
PMID: 25180753 [PubMed - in process] (Source: Chest)
Source: Chest - September 1, 2014 Category: Respiratory Medicine Authors: Peetermans M, Goeminne P, De Boeck C, Dupont LJ Tags: Chest Source Type: research

Response.
PMID: 25180752 [PubMed - in process] (Source: Chest)
Source: Chest - September 1, 2014 Category: Respiratory Medicine Authors: Agarwal R, Aggarwal AN, Gupta D Tags: Chest Source Type: research

A "ROSE" in Every "EBUS" Keeps Transbronchial Lung Biopsy Away.
PMID: 25180751 [PubMed - in process] (Source: Chest)
Source: Chest - September 1, 2014 Category: Respiratory Medicine Authors: Kumar S, Chandra S Tags: Chest Source Type: research

A 54-year-old man referred with nonresolving pneumonia.
PMID: 25180750 [PubMed - in process] (Source: Chest)
Source: Chest - September 1, 2014 Category: Respiratory Medicine Authors: Catteeuw J, Koegelenberg CF, Bruwer JW, Sissolak G, Schroeter L, Mohamed N, Irusen EM Tags: Chest Source Type: research

A 56-year-old man with acute promyelocytic leukemia and pulmonary infiltrates.
PMID: 25180749 [PubMed - in process] (Source: Chest)
Source: Chest - September 1, 2014 Category: Respiratory Medicine Authors: Weir DC, Fung JY, Braman SS Tags: Chest Source Type: research

A 46-year-old woman with left shoulder pain and worsening dyspnea.
PMID: 25180748 [PubMed - in process] (Source: Chest)
Source: Chest - September 1, 2014 Category: Respiratory Medicine Authors: Liu S, Li X, Huang X, Li T, Yang Y, Qiao R Tags: Chest Source Type: research