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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

Essential rules and requirements for global clinical trials in rare lung diseases: A sponsor׳s standpoint
Publication date: Available online 26 November 2014 Source:Respiratory Investigation Author(s): Thomas Kuerner International multicenter trials have the advantage of being able to recruit many patients within a short period. This is particularly useful for rare diseases. Ideally, conclusions drawn from the results of a global clinical trial apply to all study centers and countries involved, potentially expediting drug development and facilitating approval in foreign markets. However, several challenges must be overcome to ensure optimal trial conduct and coordinate trial sites working under different regulations and tech...
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Stratifying the risk of COPD exacerbation using the modified Medical Research Council scale: A multicenter cross-sectional CAP study
Publication date: Available online 18 November 2014 Source:Respiratory Investigation Author(s): Kazuto Matsunaga , Atsushi Hayata , Keiichiro Akamatsu , Tsunahiko Hirano , Tsutomu Tamada , Tadashi Kamei , Tohru Tsuda , Hiroyuki Nakamura , Tsuneyuki Takahashi , Soichiro Hozawa , Yoshihiro Mori , Yukihiro Sakamoto , Keiji Kimura , Uichiro Katsumata , Motohiko Miura , Masakazu Ichinose (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Heritability of pulmonary function estimated from genome-wide SNPs in healthy Japanese adults
Conclusions This study demonstrated that the heritability of pulmonary function traits can be explained by the additive effects of multiple common SNPs in healthy Japanese adults. The pulmonary function genes reported in previous GWASs of non-Japanese populations showed a definite impact of the genes on FEV1/FVC, thus indicating the presence of common pathways related to this trait beyond ethnicity. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Disease flare after gefitinib discontinuation
Conclusions Our analysis demonstrated a lower incidence rate of disease flare after gefitinib discontinuation compared with the previous report, but the prognosis was similarly poor. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Endobronchial ultrasound-guided transbronchial biopsy with or without a guide sheath for diagnosis of lung Cancer
Conclusion EBUS-GS with TBB, brushing, and bronchial washing is effective in diagnosing lung cancers sized <20mm. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

An analysis of etiology, causal pathogens, imaging patterns, and treatment of Japanese patients with bronchiectasis
Conclusions Idiopathic and sinobronchial syndrome were common causes of BE. Etiology did not contribute to imaging pattern or predictors of exacerbations. Cystic BE was a predictor for frequent exacerbations in the non-NTM BE patients. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Current status and study activity of lung cancer in Japan
Publication date: November 2014 Source:Respiratory Investigation, Volume 52, Issue 6 Author(s): Toshihiro Nukiwa (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Clinical significance of epidermal growth factor receptor tyrosine kinase inhibitors: Sensitivity and resistance
Publication date: November 2014 Source:Respiratory Investigation, Volume 52, Issue 6 Author(s): Shinji Takeuchi , Seiji Yano Gefitinib and erlotinib, which are epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), are highly effective against lung tumors with EGFR activating mutations. However, in 20–30% of cases, there is intrinsic resistance, and even if the treatment is effective, resistance is acquired in one to several years. Possible mechanisms of acquired resistance to EGFR-TKI, thus far, include a gatekeeper mutation of EGFR, activation of an alternate pathway, activation of EGFR downs...
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Efficacy of combined corticosteroid and pirfenidone for acute exacerbation of idiopathic pulmonary fibrosis after surgery for lung cancer: A case report
Publication date: Available online 18 October 2014 Source:Respiratory Investigation Author(s): Hirotsugu Ohkubo , Eiji Kunii , Satoru Moriyama , Akio Niimi (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Efficacy and long-term clinical outcome of bronchial occlusion with endobronchial Watanabe spigots for persistent air leaks
Conclusions We showed that bronchial occlusion with EWSs was effective in stopping or reducing air leaks and that 86% of our patients finally achieved complete resolution, some when the occlusion was combined with chemical pleurodesis. The rate of complications was acceptable, even after long-term placement. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

The usefulness of a disease severity staging classification system for IPF in Japan: 20 years of experience from empirical evidence to randomized control trial enrollment
Publication date: Available online 16 October 2014 Source:Respiratory Investigation Author(s): Sakae Homma , Keishi Sugino , Susumu Sakamoto Since 1991, the severity of idiopathic pulmonary fibrosis (IPF) has been classified into 4 stages—stage I (characterized by a resting PaO2≥80Torr), stage II (70–79Torr), stage III (60–69Torr), or stage IV (<60Torr)—to aid decisions on medical care subsidization in Japan. Among patients with stage II/III IPF, the severity should be increased by one stage if the lowest oxygen saturation on pulse oximetry (SpO2) is <90% during a 6-min walk test. Patients with st...
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Effects of elevated core temperature and normoxic 30% nitrous oxide on human ventilation during short duration, high intensity exercise
In conclusion, normoxic N2O breathing suppressed high intensity exercise ventilation during normothermia relative to that during hyperthermia on account of decreases in the tidal volume and this led CO2 retention. (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - December 6, 2014 Category: Respiratory Medicine Source Type: research

Biology and pathology of fibroproliferation following the acute respiratory distress syndrome
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - December 6, 2014 Category: Intensive Care Source Type: research

Extracorporal membrane oxygenation as a rescue device for post‐reperfusion cardiac arrest during liver transplantation
This article is protected by copyright. All rights reserved. (Source: Liver Transplantation)
Source: Liver Transplantation - December 6, 2014 Category: Transplant Surgery Authors: Margaret Tejani, Soo Youn Yi, Kyle W Eudailey, Isaac George, James V. Guarrera, Gebhard Wagener Tags: Letters from the Frontline Source Type: research

Zmiany ilościowe limfocytów B i ich subpopulacji CD5+ i CD23+ u dzieci szkolnych z dysplazją oskrzelowo-płucną
Conclusions 1. In schoolchildren, born preterm with respiratory insufficiency, who became sick with BPD there are quantitative changes of B lymphocytes and their subpopulation CD23+ B. 2. The severity of BPD has a crucial influence on the decrease of B lymphocytes and on the increase of CD23+ lymphocytes. 3. Quantitative analysis of B lymphocytes and CD23+ lymphocytes in schoolchildren with past severe neonatal pathology may be useful for the assessment of immunological reactions in children with BPD and for determining their immune defences. (Source: Pediatria Polska)
Source: Pediatria Polska - December 6, 2014 Category: Pediatrics Source Type: research

Improvement in lung function is associated with a decrease in serum soluble CD30 in atopic infants
Only a minority of infants with recurrent or prolonged respiratory symptoms will develop asthma. The development of asthma is speculated to be associated with T-helper cell type 1 (TH1) and type 2 (TH2) lymphocyte activity imbalance, because an inappropriate TH2 response causes pulmonary inflammation, airway eosinophilia, and airway hyperresponsiveness to various stimuli. In addition, in asthmatic inflammation, TH1 cells can contribute to TH2-type reactions by promoting T-cell migration to the airways and by enhancing T-cell–dependent IgE production in the airways. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - December 6, 2014 Category: Allergy & Immunology Authors: Anne Kotaniemi-Syrjänen, Weronika Delezuch, Anna S. Pelkonen, Kristiina Malmström, L. Pekka Malmberg, Kari Punnonen, Irma H. Matinlauri, Mika J. Mäkelä Tags: Letter Source Type: research

Pathogenesis and Risk Factors for Nontuberculous Mycobacterial Lung Disease
Nontuberculous mycobacteria (NTM) infections are broadly classified as skin and soft tissue infections, isolated lung disease, and visceral or disseminated disease. The degree of underlying immune abnormalities varies between each classification. Skin and soft tissue infections are usually the result of iatrogenic or accidental inoculation of NTM in otherwise normal hosts. Visceral and disseminated NTM disease invariably occurs in individuals with more severe immunosuppression. Although the focus of this article is to discuss the pathogenesis of NTM lung disease, the risk factors of visceral/disseminated NTM disease are al...
Source: Clinics in Chest Medicine - December 6, 2014 Category: Respiratory Medicine Authors: Jennifer R. Honda, Vijaya Knight, Edward D. Chan Source Type: research

The growing threat of nontuberculous mycobacteria in CF
There has been recent growing awareness of the threat of nontuberculous mycobacteria (NTM) to individuals with cystic fibrosis (CF) and an increasing appreciation of the difficulties in screening, diagnosing and treating NTM-pulmonary infection in the context of CF lung disease. Forthcoming joint US CFF-ECFS guidelines have been developed to assist clinicians with the management of NTM in individuals with CF. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - December 6, 2014 Category: Respiratory Medicine Authors: R. Andres Floto, Charles S. Haworth Tags: Editorial Source Type: research

Osteopontin is increased in cystic fibrosis and can skew the functional balance between ELR-positive and ELR-negative CXC-chemokines
The glycoprotein osteopontin plays important roles in several states of disease associated with inflammation, for example by recruiting neutrophils but its expression and possible roles in cystic fibrosis (CF) have not been investigated. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - December 6, 2014 Category: Respiratory Medicine Authors: Sandra Jovic, Medya Shikhagaie, Matthias Mörgelin, Jonas S. Erjefält, Sven Kjellström, Arne Egesten Tags: Original Article Source Type: research

Serum concentrations of haptoglobin and haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complexes of bovine calves in a bacterial respiratory challenge model
Conclusion: Serum Hp-MMP 9 concentration is a useful diagnostic tool for detecting early pulmonary inflammation in calves challenged with B. trehalosi and M. haemolytica. Serum Hp-MMP 9 may also be a useful tool in detecting subclinical pulmonary inflammation in challenged calves. (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - December 6, 2014 Category: Veterinary Research Authors: Christy HanthornGrant DewellRenee DewellVickie CooperChong WangPaul PlummerJeffrey Lakritz Source Type: research

[Recognize and classify pneumoconiosis.]
Abstract BACKGROUND: In the year 2012, out of the 10 most frequently recognized occupational diseases 6 were forms of pneumoconiosis. With respect to healthcare and economic aspects, silicosis and asbestos-associated diseases are of foremost importance. The latter are to be found everywhere and are not restricted to large industrial areas. PROBLEM: Radiology has a central role in the diagnosis and evaluation of occupational lung disorders. In cases of known exposure mainly to asbestos and quartz, the diagnosis of pneumoconiosis, with few exceptions will be established primarily by the radiological findings. As ...
Source: Der Radiologe - December 6, 2014 Category: Radiology Authors: Hering KG, Hofmann-Preiß K Tags: Radiologe Source Type: research

Molecular characterization of the porcine S100A6 gene and analysis of its expression in pigs infected with highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV).
Abstract Our previous microarray study revealed that S100A6 was significantly upregulated in porcine alveolar macrophages (PAMs) infected with highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). In the present study, we cloned both cDNA and genomic DNA sequences of the gene. Transient transfection indicated that the porcine S100A6 protein was located in the nucleus and cytoplasm. Reverse transcription polymerase chain reaction (RT-PCR) revealed that the porcine S100A6 gene was highly expressed in the kidney and subcutaneous fat. Polyinosinic-polycytidylic acid [poly (I:C)] induced porc...
Source: J Appl Genet - December 6, 2014 Category: Genetics & Stem Cells Authors: Zhou X, Wang P, Michal JJ, Wang Y, Zhao J, Jiang Z, Liu B Tags: J Appl Genet Source Type: research

Temporal trend, geographic distribution, and publication quality in asbestos research.
This study provides the first bibliometric analysis of scientific production in asbestos research. Interest appears to be higher in selected countries, with strong national features, and is growing again in the new millennium. PMID: 25475619 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - December 6, 2014 Category: Environmental Health Authors: Ugolini D, Bonassi S, Cristaudo A, Leoncini G, Ratto GB, Neri M Tags: Environ Sci Pollut Res Int Source Type: research

The Mechanisms of Compensatory Responses of the Respiratory System to Simulated Central Hypervolemia in Normal Subjects.
Authors: Segizbaeva MO, Donina ZA, Aleksandrov VG, Aleksandrova NP Abstract The compensatory responses of the respiratory system to simulated central hypervolemia (CHV) were investigated in 14 normal subjects. The central hypervolemia was caused by a short-time passive head-down tilt (HDT, -30°, 30 min). The results show that CHV increased the mechanical respiratory load and the airway resistance, slowed the inspiratory flow, increased the duration of the inspiratory phase, reduced the respiratory rate, but not changed the minute ventilation. CHV induced a significant rise in inspiratory swings of alveolar pressu...
Source: Advances in Experimental Medicine and Biology - December 5, 2014 Category: Research Tags: Adv Exp Med Biol Source Type: research

Extreme Respiratory Sinus Arrhythmia in Response to Superimposed Head-Down Tilt and Deep Breathing
(Source: Aviation, Space, and Environmental Medicine)
Source: Aviation, Space, and Environmental Medicine - December 5, 2014 Category: Sports Medicine Authors: Baden, Jeffrey R.Abrosimova, MariaBoulet, Lindsey M.Tymko, Michael M.Pfoh, Jamie R.Skow, Rachel J.Day, Trevor A. Source Type: research

Segmental Approach to Lung Volume Reduction Therapy for Emphysema Patients
Emphysema is often distributed heterogeneously throughout the lungs, even at the segmental level. It is important for interventional lung volume reduction therapies to target and treat the most diseased regions of the lung while preserving the less diseased functional regions. Identification and determination of the severity of emphysema can be done using the various quantification measures reviewed in this article. However, all of these measures are similar in what they quantify and are equally good indicators of emphysema. The tissue/air ratio was chosen for our purposes. Software capable of quantifying emphysema severit...
Source: Respiration - December 5, 2014 Category: Respiratory Medicine Source Type: research

Is Endoscopic Lung Volume Reduction Able to Reverse Pulmonary Hypertension in Patients with Severe Emphysema?
Respiration (Source: Respiration)
Source: Respiration - December 5, 2014 Category: Respiratory Medicine Source Type: research

Left Adrenal Biopsy Using the Convex Curvilinear Ultrasound Scope
We describe 6 cases of diagnostic fine-needle aspiration of the left adrenal gland using EUS-B. This capacity increases the diagnostic capabilities of the pulmonologist experienced in EUS-B.Respiration (Source: Respiration)
Source: Respiration - December 5, 2014 Category: Respiratory Medicine Source Type: research

Phase‐contrast helium‐3 MRI of aerosol deposition in human airways
One of the key challenges in the study of health‐related aerosols is predicting and monitoring sites of particle deposition in the respiratory tract. The potential health risks of ambient exposure to environmental or workplace aerosols and the beneficial effects of medical aerosols are strongly influenced by the site of aerosol deposition along the respiratory tract. Nuclear medicine is the only current modality that combines quantification and regional localization of aerosol deposition, and this technique remains limited by its spatial and temporal resolutions and by patient exposure to radiation. Recent work in MRI ha...
Source: NMR in Biomedicine - December 5, 2014 Category: Radiology Authors: Mathieu Sarracanie, Denis Grebenkov, Julien Sandeau, Soulé Coulibaly, Andrew R. Martin, Kyle Hill, José Manuel Pérez Sánchez, Redouane Fodil, Lionel Martin, Emmanuel Durand, Georges Caillibotte, Daniel Isabey, Luc Darrasse, Jacques Bittoun, Xavier Ma Tags: Research article Source Type: research

[Editorial] A step change for tobacco control in China?
China's people are at grave risk of tobacco-related diseases. The prevalence of smoking in China is 52·9% among men and 2·4% among women, equating to more than 300 million smokers aged 15 years and older. Annual health costs of an estimated ¥41 billion (US$5·0 billion) have been attributed to the major smoking-related diseases—cancer, cardiovascular disease, and respiratory illnesses. China signed the WHO Framework Convention on Tobacco Control in 2003, but its tobacco control efforts have fallen behind those of many developing countries. (Source: LANCET)
Source: LANCET - December 5, 2014 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research

[This Week in Medicine] December 6–12, 2014
The USA has announced new proposals to reduce the legal limit on ozone pollution from the present 75 parts per billion (ppb) concentration of ozone to between 65 ppb and 70 ppb, and will consider public comments on a 60–75 ppb range. Ozone pollution causes respiratory and cardiac illness and breathing difficulties, such as asthma. (Source: LANCET)
Source: LANCET - December 5, 2014 Category: Journals (General) Authors: The Lancet Tags: This Week in Medicine Source Type: research

Factors associated with asthma in adolescents in the city of Fortaleza, Brazil
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - December 5, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Evaluation of a Nurse-Led Educational Telephone Intervention to Support Self-Management of Patients with Chronic Obstructive Pulmonary Disease: A Randomized Feasibility Study
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 5, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Anxiety sensitivity and expectation of arousal differentially affect the respiratory response to caffeine
Conclusions The results highlight the modulating role of expectancies in respiratory responding to caffeine in low vs. high anxiety sensitive persons and might have important implications for the better understanding of unexpected panic attacks. (Source: Psychopharmacology)
Source: Psychopharmacology - December 5, 2014 Category: Psychiatry Source Type: research

Assessment of Morbidity following Insertion of Fixed Pre-surgical Infant Orthopedic Appliance in Patients with Complete Cleft Lip and Palate
Conclusions Although there was a large individual variability, the FLACC scores reducedafter 3 hours following surgical insertion of DMA and ECPR appliances. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 5, 2014 Category: ENT & OMF Source Type: research

Pan-human coronavirus and human bocavirus SYBR Green and TaqMan PCR assays; use in studying influenza A viruses co-infection and risk of hospitalization
Conclusion Our hCoV RT-PCR protocol appeared to be of adequate analytical sensitivity for diagnosis. More and larger studies are needed to confirm the role of hCoV, hBoV in causing severe disease when they co-infect with influenza A viruses. (Source: Infection)
Source: Infection - December 5, 2014 Category: Infectious Diseases Source Type: research

Avian Influenza: Recent Epidemiology, Travel-Related Risk, and Management
Abstract H5N1 influenza continues to smolder in Southeast Asia over the past 5 years, but the emergence of H7N9 in China in 2012 raised concerns for a new avian influenza threat. In contrast with H5N1 with over 650 confirmed cases over 11 years, H7N9 has infected over 450 persons within 2 years. The case fatality rate for H7N9 (35 %) is lower than for H5N1 (60 %) or H10N8 (67 %) but is comparable to that for the Middle East respiratory syndrome coronavirus (MERS CoV), another emerging zoonosis with travel-associated importations. Exposure to poultry and fomites are considered the likely sources of infection...
Source: Current Infectious Disease Reports - December 5, 2014 Category: Infectious Diseases Source Type: research

A Bayesian spatio-temporal approach for real-time detection of disease outbreaks: a case study
Conclusions: The advantages of our methodology for addressing the complicated issues of real world surveillance data applications are three-fold. We can easily incorporate additional covariate information and spatio-temporal dynamics in the data. Second, we furnish a unified framework to provide uncertainties associated with each parameter. Third, we are able to handle multiplicity issues by using a Bayesian approach. The urgent need to quickly and effectively monitor the health of the public makes our methodology a potentially plausible and useful surveillance approach for health professionals. (Source: BMC Medical Inform...
Source: BMC Medical Informatics and Decision Making - December 5, 2014 Category: Information Technology Authors: Jian ZouAlan KarrGauri DattaJames LynchShaun Grannis Source Type: research