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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

Sudden unexpected death in epilepsy: addressing the challenges.
Abstract Epilepsy is associated with a higher rate of premature death than the general population, and the commonest cause of epilepsy mortality is sudden unexpected death in epilepsy (SUDEP). It is difficult to quantify because of the variable reporting of this cause of death. Death occurs due to autonomic deregulation of cardio-respiratory pathways as a result of seizures. Measures to reduce cardio-respiratory dysfunction are discussed together with the importance of seizure control in preventing SUDEP. The role of seizure detection devices, antiepileptic drugs and the importance of providing information about SU...
Source: Epilepsy Curr - October 11, 2014 Category: Neurology Authors: Smithson WH, Colwell B, Hanna J Tags: Curr Neurol Neurosci Rep Source Type: research

Human parvovirus B19: A review.
Abstract UNLABELLED: Parvovirus B19 (B19V) is a small non-enveloped single-stranded DNA (ssDNA) virus of the family Parvoviridae, the subfamily Parvovirinae, the genus Erythrovirus and Human parvovirus B19 type species. It is a common community-acquired respiratory pathogen without ethnic, socioeconomic, gender, age or geographic boundaries. Moreover, the epidemiological and ecological relationships between human parvovirus B19, man and environment have aroused increasing interest in this virus. B19V infection is associated with a wide spectrum of clinical manifestations, some of which were well established and ...
Source: Acta Virologica - October 11, 2014 Category: Infectious Diseases Authors: Rogo LD, Mokhtari-Azad T, Kabir MH, Rezaei F Tags: Acta Virol Source Type: research

An intriguing finding in the right atrium
A 67-year-old male presented with shortness of breath, exacerbated by standing up and walking around and alleviated upon lying down. There was no associated coughing or chest pain. His medical history was notable for chronic alcohol abuse, chronic obstructive pulmonary disease and two recent admissions for aspiration pneumonitis. An inferior vena cava (IVC) filter had been placed 10 years earlier due to a pulmonary embolism. He denied illicit drug use. He was not taking any regular medications. On physical examination: T 97.6, P 100, BP 101/70, RR 30, O2 sat 95% supine and 91% upright on room air. He looked dishevelle...
Source: Heart - October 11, 2014 Category: Cardiology Authors: Schwartzenberg, S., Passeri, J. J. Tags: Image challenges, Venous thromboembolism, Clinical diagnostic tests Source Type: research

[Case Report] Dyspnoea, weight loss, fever, and headache caused by extrapulmonary tuberculosis in a prison inmate
A 55-year-old Panamanian man was referred from a penitentiary clinic to Hospital Santo Tomás in March, 2014. He presented with a 10-day history of breathing difficulty, chest pain, fever, headache, and had also lost more than 10 kg in weight over the previous 2 months. His medical and family history was unremarkable; however, he reported that he had been in contact with inmates who had had chronic cough for 2 years. The patient's vital signs were normal, apart from a respiratory rate of 28 breaths per min. (Source: LANCET)
Source: LANCET - October 11, 2014 Category: Journals (General) Authors: Musharaf Tarajia, Fabio Jaramillo, Amaranta Pernett, Nelson Santamaría, Amador Goodridge Tags: Case Report Source Type: research

Cold Spells and the Risk of Hospitalization for Asthma: New York, USA 1991–2006
Conclusions The results suggest that during prolonged periods of severe cold asthmatics may adhere to medical guidelines and limit their exposure, thereby preventing exacerbations. They may be less likely to alter their behavior in the more moderate months of November and April. (Source: Lung)
Source: Lung - October 11, 2014 Category: Respiratory Medicine Source Type: research

Nationwide patient registry for GNE myopathy in Japan
Conclusion: The Japanese Remudy-GNE myopathy is useful for clarifying the natural history of the disease and recruiting patients with genetically-confirmed GNE myopathy for clinical trials. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - October 11, 2014 Category: Internal Medicine Authors: Madoka Mori-YoshimuraYukiko HayashiNaohiro YonemotoHarumasa NakamuraMiho MurataShin¿ichi TakedaIchizo NishinoEn Kimura Source Type: research

Characterization of the chaperonin GroEL in Mycoplasma gallisepticum.
This study is the first report of the biological characterization of chaperone GroEL protein in MG. PMID: 25304689 [PubMed - as supplied by publisher] (Source: Archives of Microbiology)
Source: Archives of Microbiology - October 11, 2014 Category: Microbiology Authors: Tan L, Hu M, Yu S, Wang X, Lu F, Liu F, Qiu X, Song C, Sun Y, Ding C Tags: Arch Microbiol Source Type: research

Beyond the whole genome consensus: Unravelling of PRRSV phylogenomics using next generation sequencing technologies.
Abstract The highly heterogeneous porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent responsible for an economically important pig disease with the characteristic symptoms of reproductive losses in breeding sows and respiratory illnesses in young piglets. The virus can be broadly divided into the European and North American-like genotype 1 and 2 respectively. In addition to this intra-strains variability, the impact of coexisting viral quasispecies on disease development has recently gained much attention; owing very much to the advent of the next-generation sequencing (NGS) technolo...
Source: Virus Research - October 11, 2014 Category: Virology Authors: Lu ZH, Archibald AL, Ait-Ali T Tags: Virus Res Source Type: research

Cost-effectiveness of CPAP treatment related to cardiovascular disease in patients with severe OSAS: the Greek experience
(Source: Sleep and Breathing)
Source: Sleep and Breathing - October 10, 2014 Category: Respiratory Medicine Source Type: research

RSV and its propensity for causing bronchiolitis
Abstract Infants and young children with acute onset of wheezing and reduced respiratory airflows are often diagnosed with obstruction and inflammation of the small bronchiolar airways, i.e., bronchiolitis. The most common eitological agents causing bronchiolitis in young children are the respiratory viruses and of the commonly encountered respiratory viruses, Respiratory Syncytial Virus (RSV) has a propensity for causing bronchiolitis. Indeed, RSV bronchiolitis remains the major reason why previously healthy infants are admitted to hospital. Why RSV infection is such a predominant cause of bronchiolitis is the subject of ...
Source: The Journal of Pathology - October 10, 2014 Category: Pathology Authors: Raymond J Pickles, John DeVincenzo Tags: Invited Review Source Type: research

Comparison of PNA clamping and direct sequencing for detecting KRAS mutations in matched tumour tissue, cell block, pleural effusion and serum from patients with malignant pleural effusion
ConclusionsThe current study suggests that PNA clamping had a good concordance with direct sequencing for the detection of KRAS mutation in patients with malignant effusion. Furthermore, the good diagnostic performance obtained from pleural effusion samples provides evidence that pleural effusion can be a useful source for detecting KRAS mutation in a clinical setting, in which the collection of tumour tissues is challenging. (Source: Respirology)
Source: Respirology - October 10, 2014 Category: Respiratory Medicine Authors: Ji Young Kang, Chan Kwon Park, Chang Dong Yeo, Hea Yeon Lee, Chin Kook Rhee, Seung Joon Kim, Seok Chan Kim, Young Kyoon Kim, Mi Sun Park, Hyeon Woo Yim Tags: Original Article Source Type: research

Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD
Conclusions: We show for the first time that COPD susceptibility at young age associates with an increased systemic innate immune response to cigarette smoking. This suggests a role of systemic inflammation in the early induction phase of COPD.Trial registrationClinicaltrials.gov: NCT00807469 (Source: Respiratory Research)
Source: Respiratory Research - October 10, 2014 Category: Respiratory Medicine Authors: Susan HoonhorstWim TimensLeo KoendermanAdèle Lo Tam LoiJan-Willem LammersH BoezenAntoon van OosterhoutDirkje PostmaNick ten Hacken Source Type: research

Comparing early years and childhood experiences and outcomes in Scotland, England and three city-regions: a plausible explanation for Scottish 'excess' mortality?
Conclusion: Based on these samples, the study does not support the hypothesis that EYCE were worse in Scotland and Glasgow and the Clyde Valley. It seems, therefore (based on these data), less likely that the roots of the excess mortality observed in the Scottish areas can be explained by these factors. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - October 10, 2014 Category: Epidemiology Authors: Martin TaulbutDavid WalshJohn O¿Dowd Source Type: research

Public reporting improves antibiotic prescribing for upper respiratory tract infections in primary care: a matched-pair cluster-randomized trial in China
Conclusions: The results suggest that PR could improve prescribing practices in terms of reducing oral antibiotics and combined use of antibiotics; however, the impacts were limited. We suggest that PR would probably be enhanced by provider payment reform, management and training for providers, and health education for patients. (Source: Health Research Policy and Systems)
Source: Health Research Policy and Systems - October 10, 2014 Category: Global & Universal Authors: Lianping YangChaojie LiuLijun WangXi YinXinping Zhang Source Type: research

Retrospective observational study of patients who present to Australian rural emergency departments with undifferentiated chest pain
ConclusionsThis study has provided information on the characteristics and processes of care for patients presenting to Australian rural EDs with undifferentiated chest pain that will inform service planning and further research to evaluate the effectiveness of care for these patients. (Source: Australian Journal of Rural Health)
Source: Australian Journal of Rural Health - October 10, 2014 Category: Rural Health Authors: Tina Roche, Glenn Gardner, Peter Lewis Tags: Original Research Source Type: research

Omega‐3 Fatty Acid Supplementation Provides an Additional Benefit to a Low‐Dust Diet in the Management of Horses with Chronic Lower Airway Inflammatory Disease
Conclusions and Clinical ImportanceFeeding horses with RAO and IAD a PUFA supplement containing 1.5–3 g DHA for 2 months provides an additional benefit to low‐dust diet. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - October 10, 2014 Category: Veterinary Research Authors: N. Nogradi, L.L. Couetil, J. Messick, M.A. Stochelski, J.R. Burgess Tags: Standard Article Source Type: research

Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay
Conclusions and Clinical ImportancePlasma [NT‐proBNP] was useful for discriminating CHF from noncardiac respiratory distress. Average plasma [NT‐BNP] increased significantly as a function of HD severity using the ACVIM‐HD classification scheme. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - October 10, 2014 Category: Veterinary Research Authors: P.R. Fox, M.A. Oyama, M.J. Hezzell, J.E. Rush, T.P. Nguyenba, T.C. DeFrancesco, L.B. Lehmkuhl, H.B. Kellihan, B. Bulmer, S.G. Gordon, S.M. Cunningham, J. MacGregor, R.L. Stepien, B. Lefbom, D. Adin, K. Lamb Tags: Standard Article Source Type: research

α-Hemolysin Activity of Methicillin-Susceptible S. aureus Predicts Ventilator-Associated Pneumonia.
Conclusions. MSSA strains with strong blood-agar hemolysis and high alpha-hemolysin activity are markers for VAP, but not VAT and, might be considered in differential diagnosis and initiation of therapy. PMID: 25303310 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 10, 2014 Category: Respiratory Medicine Authors: Stulik L, Malafa S, Hudcova J, Rouha H, Henics BZ, Craven DE, Sonnevend AM, Nagy E Tags: Am J Respir Crit Care Med Source Type: research

Risk Assessment of Tuberculosis in Immunocompromised Patients - A TBNET Study.
Conclusions: Among immunocompromised patients evaluated in this study, progression towards tuberculosis was highest in HIV-infected individuals and was poorly predicted by TST or IGRAs Clinical trial registration information available at www.clinicaltrials.gov, ID NCT00707317. PMID: 25303140 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 10, 2014 Category: Respiratory Medicine Authors: Sester M, van Leth F, Bruchfeld J, Bumbacea D, Cirillo DM, Gorek Dilektasli A, Domínguez J, Duarte R, Ernst M, Oner Eyuboglu F, Gerogianni I, Girardi E, Goletti D, Janssens JP, Julander I, Lange B, Latorre I, Losi M, Markova R, Matteelli A, Milburn H, Ra Tags: Am J Respir Crit Care Med Source Type: research

PDGF Signaling in the Lung - From Lung Development and Disease to Clinical Studies.
In conclusion, while PDGF inhibition is currently used in multiple clinical trials, we suggest that more elaborate and specific approaches for spatio-temporal control of PDGF signaling are required for developing personalized approaches involving PDGF signaling in lung disease. PMID: 25303647 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - October 10, 2014 Category: Respiratory Medicine Authors: Noskovičová N, Petřek M, Eickelberg O, Heinzelmann K Tags: Am J Respir Cell Mol Biol Source Type: research

Thrombin Down-Regulates Tissue Factor Pathway Inhibitor Expression in a PI3K/NFκB-Dependent Manner in Human Pleural Mesothelial Cells.
Abstract Tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the extrinsic coagulation cascade and its expression is reported to be relatively stable. Various pathophysiologic agents have been shown to influence TFPI activity either by regulating its expression or modifying the protein. It is not clear how TFPI activity is regulated in normal physiology or in injury. Because thrombin and TFPI are both locally elaborated in pleural injury, we sought to determine if thrombin could regulate TFPI in human pleural mesothelial cells (HPMCs). Thrombin significantly decreased TFPI mRNA and protein levels by ...
Source: Am J Respir Cell Mol... - October 10, 2014 Category: Respiratory Medicine Authors: Jeffers A, Owens S, Koenig K, Quaid B, Pendurthi UR, Rao LV, Idell S, Tucker TA Tags: Am J Respir Cell Mol Biol Source Type: research

Acute flaccid paralysis with anterior myelitis - california, june 2012-june 2014.
Abstract In August 2012, the California Department of Public Health (CDPH) was contacted by a San Francisco Bay area clinician who requested poliovirus testing for an unvaccinated man aged 29 years with acute flaccid paralysis (AFP) associated with anterior myelitis (i.e., evidence of inflammation of the spinal cord involving the grey matter including anterior horn cell bodies) and no history of international travel during the month before symptom onset. Within 2 weeks, CDPH had received reports of two additional cases of AFP with anterior myelitis of unknown etiology. Testing at CDPH's Viral and Rickettsial Diseas...
Source: MMWR Morb Mortal Wkl... - October 10, 2014 Category: Epidemiology Authors: Ayscue P, Haren KV, Sheriff H, Waubant E, Waldron P, Yagi S, Yen C, Clayton A, Padilla T, Pan C, Reichel J, Harriman K, Watt J, Sejvar J, Nix WA, Feikin D, Glaser C, Ek M Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Acute neurologic illness of unknown etiology in children - colorado, august-september 2014.
Abstract On September 12, 2014, CDC was notified by the Colorado Department of Public Health and Environment of a cluster of nine children evaluated at Children's Hospital Colorado with acute neurologic illness characterized by extremity weakness, cranial nerve dysfunction (e.g., diplopia, facial droop, dysphagia, or dysarthria), or both. Neurologic illness onsets occurred during August 8-September 15, 2014. The median age of the children was 8 years (range = 1-18 years). Other than neck, back, or extremity pain in some patients, all had normal sensation. All had a preceding febrile illness, most with upper respira...
Source: MMWR Morb Mortal Wkl... - October 10, 2014 Category: Epidemiology Authors: Pastula DM, Aliabadi N, Haynes AK, Messacar K, Schreiner T, Maloney J, Dominguez SR, Davizon ES, Leshem E, Fischer M, Nix WA, Oberste MS, Seward J, Feikin D, Miller L Tags: MMWR Morb Mortal Wkly Rep Source Type: research

The Role of Donor Chronic Alcohol Abuse in the Development of Primary Graft Dysfunction in Lung Transplant Recipients.
Abstract : Primary graft dysfunction (PGD) following lung transplantation is clinically similar to the acute respiratory distress syndrome. Because alcohol abuse independently increases the incidence of acute respiratory distress syndrome in at-risk individuals, we hypothesized that donor alcohol use is correlated with an increased risk of PGD. As a pilot study, we collected alcohol use histories using a validated instrument, the Alcohol Use Disorder Identification Test questionnaire, from 74 donors and correlated these with the development of PGD in corresponding recipients. Nineteen percent (14/74) of donors were...
Source: The American Journal of the Medical Sciences - October 10, 2014 Category: Journals (General) Authors: Pelaez A, Mitchell PO, Shah NS, Force SD, Elon L, Brown LA, Guidot DM Tags: Am J Med Sci Source Type: research

Inflammatory Patterns in Asthmatic Children Based on Alveolar Nitric Oxide Determination.
CONCLUSIONS: Normal values obtained are similar to those previously reported. Asthmatics with high CANO showed higher morbidity. No correlation was found between proximal and distal inflammation. PMID: 25311845 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 10, 2014 Category: Respiratory Medicine Authors: Corcuera-Elosegui P, Sardón-Prado O, Aldasoro-Ruiz A, Korta-Murua J, Mintegui-Aramburu J, Emparanza-Knorr JI, Pérez-Yarza EG Tags: Arch Bronconeumol Source Type: research

Late-onset Glycogen Storage Disease type 2.
Abstract Glycogenosis II (GSDII) is an autosomal recessive lysosomal storage disorder resulting from acid alpha-glucosidase (GAA) deficiency, subsequent lysosomal accumulation of glycogen in muscles, impairment of autophagic processes and progressive cardiac, motor and respiratory failure. The infantile form usually appears in the first month of life, progresses rapidly and presents with severe cardiac involvement and complete deficiency of alpha-glucosidase activity (< 1% of normal controls). The late-onset form is characterized by great variability of the phenotypical spectrum. Main findings are muscle weaknes...
Source: Current Molecular Medicine - October 10, 2014 Category: Molecular Biology Authors: Filosto M, Cotelli MS, Vielmi V, Todeschini A, Rinaldi F, Rota S, Scarpelli M, Padovani A Tags: Curr Mol Med Source Type: research

Mitochondrial Disorders in Adults.
Abstract Mitochondrial Disorders (MD) include a heterogeneous group of inherited disorders due to molecular defects mainly affecting the mitochondrial oxidative phosphorylation system. Because the respiratory chain is under control of two different genomes (nuclear DNA-nDNA and mitochondrial DNA-mtDNA), mitochondrial genetics is quite complex and may justify the extreme clinical heterogeneity of these diseases. Clinically, MD usually involve multiple tissues, mainly affecting organs with high energy request as central nervous system and skeletal muscle. They may present at any age, with different onsets, clinical p...
Source: Current Molecular Medicine - October 10, 2014 Category: Molecular Biology Authors: Toscano A, Musumeci O Tags: Curr Mol Med Source Type: research

Mitochondrial Diseases in Childhood.
Abstract Mitochondrial disorders are a group of heterogeneous diseases associated with abnormalities of the oxidative phosphorylation (OXPHOS), the most important source of energy for the cell. The number of mitochondrial syndromes and of identified causative genes is constantly increasing. Taken as a whole they are among the most frequent genetic diseases in humans at any age. The respiratory chain is the only metabolic pathway under double genome control and molecular genetics of these disorders is complicated by the existence of strict interactions between mitochondrial DNA and nuclear DNA. In childhood and infa...
Source: Current Molecular Medicine - October 10, 2014 Category: Molecular Biology Authors: Ardissone A, Lamantea E, Invernizzi F, Zeviani M, Genitrini S, Moroni I, Uziel G Tags: Curr Mol Med Source Type: research

Usefulness of phrenic latency and forced vital capacity in patients with ALS with latent respiratory dysfunction
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease that involves upper and lower motor neurons. Presently, there is no effective treatment for this disease. The main etiology of death in patients with ALS is respiratory failure caused by dysfunction of the diaphragm. Although symptoms of respiratory distress are uncommon in the early stage of ALS, except in bulbar-onset ALS (Evangelista et al., 1995), all patients eventually suffer from respiratory discomfort by progressive diaphragmatic weakness, which results in death or tracheostomy within 4 years from onset of disease (Ilzecka et al....
Source: Clinical Neurophysiology - October 10, 2014 Category: Neuroscience Authors: Soonwook Kwon, Ju-Hong Min, Hye-Jin Cho, Byung-Euk Joo, Eunbin Cho, Jin Myoung Seok, Min-Ji Kim, Byoung Joon Kim Source Type: research

Unintentional intramuscular administration of tPA/DNase for pleural infection
We report a patient treated in another center who was unintentionally administered up to six instillations of tPA (10 mg) and DNase (5 mg) intramuscularly via a malpositioned chest drain. The patient experienced minimal discomfort, and there were no signs of tissue inflammation or necrosis on computed tomography. No complications were detected over a 2‐month follow‐up. Upon transfer, a new pleural drain was inserted and tPA/DNase administered with clearance of his loculated complicated parapneumonic effusion. This case adds to the safety profile of intrapleural tPA/DNase therapy and highlights the importance of cor...
Source: Respirology Case Reports - October 10, 2014 Category: Respiratory Medicine Authors: Natalia Popowicz, Michael Nash, Y. C. Gary Lee Tags: Case Report Source Type: research

Therapeutic plasmapheresis in geriatric patients: Favorable results
Therapeutic plasma exchange, is generally a tolerable procedure, although several complications should be considered. Since geriatric population has been growing worldwide, the aim of this study was to retrospectively analyze 4709 TPE data from 981 geriatric procedures (20.8%) and to compare them with 3728 non-geriatric procedures (79.2%). The most common indications for TPE in both groups were sepsis/adult respiratory distress syndrome and multiple organ dysfunction. In geriatric patient group, contrary to expectations of aggravation, complication rate was statistically similar with non-geriatric group (P>0.05). (Source: ...
Source: Transfusion and Apheresis Science - October 10, 2014 Category: Hematology Authors: Pinar Ataca, Oya Adsiz Marasuna, Erol Ayyildiz, Meltem Bay, Osman Ilhan Source Type: research

Evaluation of energetic metabolism in the rat brain after meningitis induction by Klebsiella pneumoniae.
Discussion Although descriptive, our results show that antibiotic prevented in part the changes of the mitochondrial respiratory chain. The meningitis model could be a good research tool to study the biological mechanisms involved in the pathophysiology of the K. pneumoniae meningitis. PMID: 25287310 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - October 9, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Effects of maintenance electroshock on mitochondrial respiratory chain and creatine kinase activities in the rat brain.
Authors: Réus GZ, Stringari RB, Rezin GT, Pezente DP, Scaini G, Maggi DD, De-Nês BT, Streck EL, Quevedo J, Feier G PMID: 25286992 [PubMed] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - October 9, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Cholinergic epithelial cell with chemosensory traits in murine thymic medulla
Abstract Specialized epithelial cells with a tuft of apical microvilli (“brush cells”) sense luminal content and initiate protective reflexes in response to potentially harmful substances. They utilize the canonical taste transduction cascade to detect “bitter” substances such as bacterial quorum-sensing molecules. In the respiratory tract, most of these cells are cholinergic and are approached by cholinoceptive sensory nerve fibers. Utilizing two different reporter mouse strains for the expression of choline acetyltransferase (ChAT), we observed intense labeling of a subset of thymic medullary cells. ChAT...
Source: Cell and Tissue Research - October 9, 2014 Category: Cytology Source Type: research

Sudden Unexpected Death in Epilepsy: Addressing the Challenges
Abstract Epilepsy is associated with a higher rate of premature death than the general population, and the commonest cause of epilepsy mortality is sudden unexpected death in epilepsy (SUDEP). It is difficult to quantify because of the variable reporting of this cause of death. Death occurs due to autonomic deregulation of cardio-respiratory pathways as a result of seizures. Measures to reduce cardio-respiratory dysfunction are discussed together with the importance of seizure control in preventing SUDEP. The role of seizure detection devices, antiepileptic drugs and the importance of providing information about ...
Source: Current Neurology and Neuroscience Reports - October 9, 2014 Category: Neuroscience Source Type: research

Diagnosis and management of nontuberculous mycobacterial lung infections
Abstract The diagnosis and management of nontuberculous mycobacterial (NTM) lung infection remains difficult even among experienced clinicians. Both the incidence and prevalence are likely expected to rise with an aging population. Careful assessment of clinical, radiologic, and microbiologic studies is warranted before initiating therapy, which is often complicated by significant drug side effects and limited sputum conversion rates. Indications to treat are best based on a number of factors, including specific NTM species, NTM lung-infection–associated symptoms, advanced bronchiectatic or cavitary disease, exp...
Source: Current Respiratory Care Reports - October 9, 2014 Category: Respiratory Medicine Source Type: research

Optic Neuropathy, Myelopathy, Anemia, and Neutropenia Caused by Acquired Copper Deficiency After Gastric Bypass Surgery
Malabsorptive bariatric surgery is rapidly becoming a major cause of copper deficiency given the increasing prevalence of these procedures for morbid obesity. Acquired copper deficiency can present with clinically significant hematologic and neurological manifestations. Although hematologic manifestations of copper deficiency are rapidly reversible, significant neurological improvement after copper supplementation therapy is unusual and many patients remain debilitated and may only experience, at best, stabilization of the neurological manifestations. Here we present a case of an undiagnosed copper deficiency several years...
Source: Journal of Clinical Gastroenterology - October 9, 2014 Category: Gastroenterology Tags: ALIMENTARY TRACT: Case Report Source Type: research

Safety and Effectiveness of Palivizumab in Children at High Risk of Serious Disease Due to Respiratory Syncytial Virus Infection: A Systematic Review
Conclusion Rates of RSV hospitalizations and RSV hospitalization-related endpoints in pediatric subjects who received prophylaxis with palivizumab were low and constant over time and across RCTs, open-label non-comparative trials, and observational studies/registries. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - October 9, 2014 Category: Infectious Diseases Source Type: research

Imaging adults on extracorporeal membrane oxygenation (ECMO)
This article will describe the imaging appearance of different ECMO circuits in adults as well as commonly encountered complications. If a CT (computed tomography) angiogram is being performed on these patients to evaluate for pulmonary embolism, the scan may be suboptimal from siphoning off of the contrast by the ECMO. In such cases, an optimal image can be obtained by lowering the flow rate of the ECMO circuit or by disabling the circuit for the duration of image acquisition. Key Points • Femoroatrial VV ECMO: femoral vein drainage cannula and right atrial return cannula. ...
Source: Insights into Imaging - October 9, 2014 Category: Radiology Source Type: research

Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough?
Conclusion Although patients treated at HV hospitals had more medical comorbidities, outcomes across a wide spectrum of quality metrics were better than at IV or LV hospital following complex HPB surgery. A 20–30 % reduction in morbidity and mortality and an 8 % reduction in hospital patient-days could be anticipated had all patients been treated at HV hospitals. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - October 9, 2014 Category: Surgery Source Type: research

Do Electronic cigarettes impart a lower potential disease burden than conventional tobacco cigarettes?: Review on e‐cigarette vapor versus tobacco smoke
ConclusionBased on the comparison of the chemical analysis of EC and TC carcinogenic profiles and association with health‐indicating parameters, ECs impart a lower potential disease burden than conventional TCs. Laryngoscope, 2014 (Source: The Laryngoscope)
Source: The Laryngoscope - October 9, 2014 Category: ENT & OMF Authors: Anne Y. Oh, Ashutosh Kacker Tags: General Otolaryngology Source Type: research

Specificity of Quantitative Latex Agglutination Assay for D-dimer in Exclusion of Pulmonary Embolism in the Emergency Department
We assessed the prevalence of elevated quantitative latex agglutination assay for D-dimer in patients in the emergency department in whom pulmonary embolism (PE) was excluded. D-dimer was normal (<230 ng/mL) in 435 (83%) of the 522 patients. D-dimer was normal in 88% of the patients with musculoskeletal or related chest pain, 74% with pleurisy or pleuritic chest pain, and 85% with upper respiratory tract infection. D-dimer was 230 to 500 ng/mL in 65 (75%) of the 87 in whom D-dimer was elevated. Clinical probability was low in 31 (48%) of the 65 patients with D-dimer levels of 230 to 500 ng/mL. D-dimer was 230 to 500 ng/...
Source: Clinical and Applied Thrombosis/Hemostasis - October 9, 2014 Category: Hematology Authors: Stein, P. D., Matta, F., Sabra, M. J., Tana, C., Gough, A., Chabala, S., Kakish, E., Tworek, J. Tags: Original Articles Source Type: research

Laboratory capability and surveillance testing for Middle East respiratory syndrome coronavirus infection in the WHO European Region, June 2013
(Source: Eurosurveillance latest news)
Source: Eurosurveillance latest news - October 9, 2014 Category: Infectious Diseases Source Type: research

Towards better‐quality research reporting in Respirology
(Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Peter Eastwood, Lieve Bultynck, Anke van Eekelen, Christel Norman Tags: EDITORIAL Source Type: research

Detecting anxiety and depression in patients diagnosed with an interstitial lung disease. Can we do better?
See article, page 1215 (Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Anne Marie Russell, Toby M Maher Tags: EDITORIAL Source Type: research

Molecular alterations in non‐small‐cell lung cancer: Perspective for targeted therapy and specimen management for the bronchoscopist
Abstract Major advances have occurred over the past decade in our understanding of lung cancer pathobiology. Increasing knowledge of molecular aberrations in lung cancer, specifically the discovery of two driver genes in pharmacologically targetable tyrosine kinases involved in growth factor receptor signalling, epidermal growth factor receptor and anaplastic lymphoma kinase, has been of major therapeutic and prognostic importance. This discovery has allowed for new, personalized approach to the management of lung cancer. Recognizing the importance of molecular signatures of lung cancer, the College of American Pathologist...
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Kasia Czarnecka‐Kujawa, Kazuhiro Yasufuku Tags: Invited review series: Update in Interventional Pulmonology Source Type: research