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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

Cohort Profile: The Study of Respiratory Pathogens in Andean Children
We investigated respiratory pathogens in a prospective cohort study of young children living in the Peruvian Andes. In the study we assessed viral respiratory infections among young children, and explored interactions of viruses with common respiratory bacteria, especially Streptococcus pneumoniae. Through weekly household visits, data were collected on the signs and symptoms of acute respiratory illness (ARI), nasal samples were collected to test for viruses during episodes of ARI, and nasopharyngeal samples were collected on a monthly basis to monitor bacterial colonisation. We also collected data on vaccination coverage...
Source: International Journal of Epidemiology - August 4, 2014 Category: Epidemiology Authors: Grijalva, C. G., Griffin, M. R., Edwards, K. M., Williams, J. V., Gil, A. I., Verastegui, H., Hartinger, S. M., Vidal, J. E., Klugman, K. P., Lanata, C. F. Tags: Cohort Profiles Source Type: research

Cohort Profile: The Limache, Chile, birth cohort study
The Limache cohort was set up to assess the programming and life course events hypotheses in relation to cardiovascular risk factors and chronic respiratory conditions, especially asthma, in the context of an unprecedented economic growth in Chile. The cohort was a representative sample of 1232 participants born between 1974 and 1978 in the hospital of Limache. The study includes data collected at birth, during the 1st year of life, at 22 to 28 years (collected between 2000 and 2002) and at 32 to 38 years (collected between 2010 and 2012). The data collected include anthropometric measurements at birth, 1st year of life an...
Source: International Journal of Epidemiology - August 4, 2014 Category: Epidemiology Authors: Amigo, H., Bustos, P., Zumelzu, E., Rona, R. J. Tags: Cohort Profiles Source Type: research

FOXF1 Transcription Factor Is Required for Formation of Embryonic Vasculature by Regulating VEGF Signaling in Endothelial Cells.
Conclusions: FOXF1 is required for formation of embryonic vasculature by regulating endothelial genes critical for vascular development and VEGF signaling. PMID: 25091710 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - August 4, 2014 Category: Cardiology Authors: Ren X, Ustiyan V, Pradhan A, Cai Y, Havrilak JA, Bolte CS, Shannon JM, Kalin TV, Kalinichenko VV Tags: Circ Res Source Type: research

Capsaicin cough threshold test in diagnostics
Among patients with chronic unexplained cough, there is a recognized subgroup with respiratory symptoms induced by environmental irritants like chemicals and odours. The diagnosis of sensory hyperreactivity (SHR) has been suggested for this group of patients and can be made using a tidal breathing capsaicin inhalation test. The aim of the present study was to evaluate the ability of a single-breath, dose-response capsaicin threshold test to discriminate such patients from control subjects. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 4, 2014 Category: Respiratory Medicine Authors: Teet Pullerits, Ewa Ternesten-Hasséus, Ewa-Lena Johansson, Eva Millqvist Source Type: research

Pooled safety analysis of the fixed-dose combination of indacaterol and glycopyrronium, its monocomponents, and tiotropium versus placebo in COPD patients
To further assess the safety profile of the fixed-dose combination of indacaterol and glycopyrronium (QVA149) and its monocomponents; we investigated the impact of individual patient-level factors and time by integrating the patient-level safety data from the QVA149 clinical programme with relevant information from the independent indacaterol and glycopyrronium safety databases. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 4, 2014 Category: Respiratory Medicine Authors: Jadwiga A. Wedzicha, Ronald Dahl, Roland Buhl, Agnes Schubert-Tennigkeit, Hungta Chen, Peter D’Andrea, Robert Fogel, Donald Banerji Source Type: research

Agmatine-containing poly(amidoamine)s as novel class of antiviral macromolecules: structural properties and in vitro evaluation of infectivity inhibition.
Abstract Poly(amidoamine)s (PAAs) are multifunctional tert-amine polymers endowed with high structural versatility. Here we report on the screening of a minilibrary of PAAs against a panel of viruses. The PAA AGMA1 showed antiviral activity against herpes simplex virus, human cytomegalovirus, human papillomavirus-16, and respiratory syncytial virus, but not against human rotavirus and vesicular stomatitis virus. The results suggest the contribution of both polycationic nature and side guanidine groups in imparting antiviral activity. PMID: 25092704 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - August 4, 2014 Category: Infectious Diseases Authors: Donalisio M, Ranucci E, Cagno V, Civra A, Manfredi A, Cavalli R, Ferruti P, Lembo D Tags: Antimicrob Agents Chemother Source Type: research

New Therapeutic Targets in Idiopathic Pulmonary Fibrosis: Aiming to Rein in Runaway Wound Healing Responses.
Abstract Idiopathic pulmonary fibrosis (IPF) is a devastating disease, with a median survival as short as 3 years from the time of diagnosis, and no pharmacological therapies yet approved by the US Food and Drug Administration (FDA). To address the great unmet need for effective IPF therapy, a number of new drugs have recently been, or are now being, evaluated in clinical trials. The rationales for most of these therapeutic candidates are based on the current paradigm of IPF pathogenesis, in which recurrent injury to the alveolar epithelium is thought to drive aberrant wound healing responses, resulting in fibrosis...
Source: American Journal of Respiratory and Critical Care Medicine - August 4, 2014 Category: Respiratory Medicine Authors: Ahluwalia N, Shea BS, Tager AM Tags: Am J Respir Crit Care Med Source Type: research

A Functional Synonymous Coding Variant in the IL1RN Gene Associates with Survival in Septic Shock.
Conclusions: In European ancestry subjects, the IL1RN variant rs315952C is preferentially transcribed, associates with increased evoked plasma IL1RA, and with improved survival from septic shock. It may be that genetically determined IL1RA levels influence survival from septic shock. PMID: 25089931 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 4, 2014 Category: Respiratory Medicine Authors: Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP Tags: Am J Respir Crit Care Med Source Type: research

Multicenter Development and Validation of a Risk Stratification Tool for Ward Patients.
Conclusions: We developed an accurate ward risk stratification tool using commonly collected EHR variables in a large multicenter dataset. Further study is needed to determine whether implementation in real-time would improve patient outcomes. PMID: 25089847 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 4, 2014 Category: Respiratory Medicine Authors: Churpek MM, Yuen TC, Winslow C, Robiscek AA, Meltzer DO, Gibbons RD, Edelson DP Tags: Am J Respir Crit Care Med Source Type: research

Is Acute Respiratory Failure Requiring Mechanical Ventilation Associated with Development of Takotsubo Cardiomyopathy in the Critical Care Setting?
Takotsubo cardiomyopathy (TCC) is a reversible cardiomyopathy characterized by apical or midventricular wall motion abnormalities, despite non obstructive coronary artery disease. Its pathogenesis remains unclear however several hypotheses have been proposed, including excess catecholamine release, coronary arterial spasm, transient obstruction of the LV outflow tract, and microvascular dysfunction [1–3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 4, 2014 Category: Cardiology Authors: Emiliana Franco, Andre Dias, Vincent M. Figueredo, Kathy Hebert Source Type: research

Personalized CHF treatment: PCT to guide therapy in heart failure patients
Sorting out the etiology of dyspnea in patients with a history of heart failure is not always straightforward. Although an acute heart failure exacerbation would seem to be easy to distinguish from an acute respiratory illness, data from objective clinical studies has shown otherwise. Procalcitonin (PCT), a biomarker that rises in the setting of bacterial infection, carries great potential for guiding the diagnosis and treatment of heart failure patients with possible acute respiratory infection. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 4, 2014 Category: Cardiology Authors: Noel S. Lee, Lori B. Daniels Source Type: research

Whole Genome Expression Analysis in Primary Bronchial Epithelial Cells after Exposure to Sulphur Mustard.
Abstract Sulphur mustard (SM) is a highly toxic chemical agent and poses a current threat to both civilians and military personnel in the event of a deliberate malicious release. Acute SM toxicity develops over the course of several hours and mainly affects the skin and mucosal surfaces of the eyes and respiratory system. In cases of acute severe exposure, significant lung injury can result in respiratory failure and death. Systemic levels of SM can also be fatal, frequently due to immunodepletion and the subsequent development of secondary infections. Whilst the physical effects associated with SM exposure are wel...
Source: Toxicology Letters - August 4, 2014 Category: Toxicology Authors: Jowsey PA, Blain PG Tags: Toxicol Lett Source Type: research

Development of an EvaGreen-based multiplex real-time PCR assay with melting curve analysis for simultaneous detection and differentiation of six viral pathogens of porcine reproductive and respiratory disorder.
Abstract Concurrent infection of pigs with two or more pathogens is common in pigs under intensive rearing conditions. Porcine circovirus type 2 (PCV2), porcine parvovirus (PPV), porcine reproductive and respiratory syndrome virus (PRRSV), classical swine fever virus (CSFV), Japanese encephalitis virus (JEV) and pseudorabies virus (PRV) are all associated with reproductive or respiratory disorders or both and can cause significant economic losses in pig production worldwide. An EvaGreen-based multiplex real-time PCR (EG-mPCR) with melting curve analysis was developed in this study for simultaneous detection and dif...
Source: Journal of Virological Methods - August 4, 2014 Category: Virology Authors: Rao P, Wu H, Jiang Y, Opriessnig T, Zheng X, Mo Y, Yang Z Tags: J Virol Methods Source Type: research

Porcine reproductive and respiratory syndrome virus counteracts the porcine intrinsic virus restriction factors-IFITM1 and Tetherin in MARC-145 cells.
This study presents the first demonstration that the nonstructural protein 3 (Nsp3) or envelope (E) protein of PRRSV interacted with porcine intrinsic virus-restriction factor IFITM1 or Tetherin. Next, in PRRSV-infected MARC-145 cells and the transfected cells with the IFITM1- or Tetherin-expressing plasmid, IFITM1 was shown to be mainly distributed perinuclear, and Tetherin was proposed to be partially removed away from cell surface. Moreover, the overexpression of IFITM1 and Tetherin were shown to have no obvious effects on the replication of PRRSV in MARC-145 cells. The Nsp3 of PRRSV was demonstrated to induce the prote...
Source: Virus Research - August 4, 2014 Category: Virology Authors: Wang X, Li C, Zhou L, Zhang N, Wang X, Ge X, Guo X, Yang H Tags: Virus Res Source Type: research

A case of aortic and mitral valve involvement in granulomatosis with polyangiitis
We report the case of a 60 year-old woman with arthritis and lung nodules due to GPA without anti-neutrophil cytoplasmic antibodies (ANCA) at time of diagnosis. Remission was obtained with cyclophosphamide (CYC) and corticosteroid. Azathioprine was then prescribed for 2 years. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 4, 2014 Category: Cardiology Authors: O. Espitia, L. Droy, S. Pattier, F. Naudin, A. Mugniot, A. Cavailles, M. Hamidou, P. Bruneval, Agard, C. Toquet Source Type: research

Repair of Primary or Complicated Aortic Coarctation in the Adult Using Cardiopulmonary Bypass and Hypothermic Circulatory Arrest
Twenty-seven adult patients with primary aortic coarctation with or without associated abnormalities or with complications of previous coarctation repair underwent open repair using total hypothermic cardiopulmonary bypass and hypothermic circulatory arrest. There were no hospital deaths, and no patient sustained a stroke, spinal cord ischemic injury, renal or respiratory failure. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - August 4, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Nicholas T. Kouchoukos, James R. Scharff, Catherine F. Castner Source Type: research

[Infantile spinal atrophy: Our experience in the last 25 years.]
CONCLUSIONS: The incidence in our population remains stable at around 1/10.000. Most cases presented with, predominantly male, typical genetics. In approximately 1/10 patients the genetic alteration was different from the classical one to the SMN gene. The prevalence of AME unrelated SMN gene was 1/37. The level of care has increased in line with social and welfare demands in recent years. PMID: 25103837 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - August 4, 2014 Category: Pediatrics Authors: Madrid Rodríguez A, Martínez Martínez PL, Ramos Fernández JM, Urda Cardona A, Martínez Antón J Tags: An Pediatr (Barc) Source Type: research

Assessing the relationship among urban trees, nitrogen dioxide, and respiratory health.
Abstract Modeled atmospheric pollution removal by trees based on eddy flux, leaf, and chamber studies of relatively few species may not scale up to adequately assess landscape-level air pollution effects of the urban forest. A land use regression (LUR) model (R(2) = 0.70) based on NO2 measured at 144 sites in Portland, Oregon (USA), after controlling for roads, railroads, and elevation, estimated every 10 ha (20%) of tree canopy within 400 m of a site was associated with a 0.57 ppb decrease in NO2. Using BenMAP and a 200 m resolution NO2 model, we estimated that the NO2 reduction associated with trees in Port...
Source: Environmental Pollution - August 4, 2014 Category: Environmental Health Authors: Rao M, George LA, Rosenstiel TN, Shandas V, Dinno A Tags: Environ Pollut Source Type: research

Development of Three Methods for Extracting Respiration from the Surface ECG: A Review
Respiration rate (RR) is a critical vital sign that can be monitored to detect acute changes in patient condition (e.g., apnea) and potentially provide an early warning of impending life-threatening deterioration. Monitoring respiration signals is also critical for detecting sleep disordered breathing such as sleep apnea. Additionally, analyzing a respiration signal can enhance the quality of medical images by gating image acquisition based on the same phase of the patient's respiratory cycle. Although many methods exist for measuring respiration, in this review we focus on three ECG-derived respiration techniques we devel...
Source: Journal of Electrocardiology - August 4, 2014 Category: Cardiology Authors: Eric Helfenbein, Reza Firoozabadi, Simon Chien, Eric Carlson, Saeed Babaeizadeh Source Type: research

Inhaled anticholinergics and short-acting beta2-agonists versus short-acting beta2-agonists alone for children with acute asthma in hospital.
CONCLUSIONS: In children hospitalised for an acute asthma exacerbation, no evidence of benefit for length of hospital stay and other markers of response to therapy was noted when nebulised anticholinergics were added to short-acting β2-agonists. No adverse health effects were reported, yet the small number of trials combined with inadequate reporting prevent firm reassurance regarding the safety of anticholinergics. In the absence of trials conducted in ICUs, no conclusion can be drawn regarding children with impending respiratory failure. These findings support current national and international recommendations indicatin...
Source: Cochrane Database of Systematic Reviews - August 3, 2014 Category: Journals (General) Authors: Vézina K, Chauhan BF, Ducharme FM Tags: Cochrane Database Syst Rev Source Type: research

Nalbuphine for postoperative pain treatment in children.
CONCLUSIONS: Because the overall quality of available evidence was low, this systematic review could not definitively show that the analgesic efficacy of nalbuphine is superior compared to placebo. Furthermore, due to the lack of significant results the comparison with other common opioids is also unclear. The same holds true for the evidence focusing on adverse events following nalbuphine compared to placebo or other opioid administration. The evidence is limited, because studies did not report conclusively all important postoperative pain outcomes (e.g. number of patients with the need for rescue analgesia, postoperative...
Source: Cochrane Database of Systematic Reviews - August 3, 2014 Category: Journals (General) Authors: Schnabel A, Reichl SU, Zahn PK, Pogatzki-Zahn E Tags: Cochrane Database Syst Rev Source Type: research

Isolated primary pancreatic Wegener's granulomatosis: report of two cases.
CONCLUSIONS: Benign diseases such as Tuberculosis may mimic pancreatic tumours diagnosed on cross-sectional imaging. Wegener's granulomatosis should be included in the differential diagnosis of an isolated pancreatic mass, in the absence of other cardinal symptoms for malignancy, due to the extensive surgery and risks involved in resection of pancreas. PMID: 25076354 [PubMed - in process] (Source: JOP)
Source: JOP - August 3, 2014 Category: Gastroenterology Authors: Kontis E, Papalexopoulou N, Zen Y, Prachalias AA Tags: JOP Source Type: research

Chronic lung disease of prematurity and early childhood wheezing: Is foetal inflammatory response syndrome to blame?
Long-lasting respiratory symptoms have a huge impact on the quality of life in prematurely born children. (Source: Early Human Development)
Source: Early Human Development - August 3, 2014 Category: Perinatology & Neonatology Authors: Nada Sindičić Dessardo, Sandro Dessardo, Elvira Mustać, Srđan Banac, Oleg Petrović, Branimir Peter Source Type: research

Perceived quality of life in chronic obstructive pulmonary disease patients: a cross-sectional study in primary care on the role of illness perceptions
Conclusions: Patients who experience fewer symptoms attributed to COPD, who have a better understanding of the disease, who experience less impact of COPD in daily life, who experience better treatment control and who have less of an emotional response have better HRQoL. This study indicates that the HRQoL of COPD patients is associated with illness perceptions as well as with the severity of dyspnoea as experienced by patients. Airflow limitation measures or comorbidities do not add to the explanation of HRQoL. The results of this study provide starting points for the development of interventions focusing on illness perce...
Source: BMC Family Practice - August 3, 2014 Category: Primary Care Authors: Saskia WeldamJan-Willem LammersMonique HeijmansMarieke Schuurmans Source Type: research

Monitoring of occupational and environmental aeroallergens – EAACI Position Paper
Abstract Exposure to high molecular weight sensitizers of biological origin is an important risk factor for the development of asthma and rhinitis. Most of the causal allergens have been defined based on their reactivity with IgE antibodies, and in many cases, the molecular structure and function of the allergens have been established. Significant information on allergen levels that cause sensitization and allergic symptoms for several major environmental and occupational allergens has been reported. Monitoring of high molecular weight allergens and allergen carrier particles is an important part of the management of aller...
Source: Allergy - August 3, 2014 Category: Allergy & Immunology Authors: M. Raulf, J. Buters, M. Chapman, L. Cecchi, F. Blay, G. Doekes, W. Eduard, D. Heederik, M. F. Jeebhay, S. Kespohl, E. Krop, G. Moscato, G. Pala, S. Quirce, I. Sander, V. Schlünssen, T. Sigsgaard, J. Walusiak‐Skorupa, M. Wiszniewska, I. M. Wouters, I. A Tags: Position Paper Source Type: research

Paracoccus pacificus sp. nov., isolated from the Western Pacific Ocean.
Abstract A Gram-stain negative, short rod-shaped, non-motile, catalase- and oxidase-positive, aerobic bacterium, designated F14(T), was isolated from the Western Pacific Ocean. Phylogenetic and phenotypic properties of the organism supported that it belongs to the genus Paracoccus. The levels of 16S rRNA gene sequences similarity between strain F14(T) and other type strains of recognized members of the genus Paracoccus were 93.6-96.5 %. Growth of strain F14(T) was observed at 4-40 °C (optimum, 28-30 °C), pH 6.0-10.0 (optimum, pH 7.0-8.0) and in the presence of 0-7 % (w/v) NaCl (optimum, 1-2 %). The major cel...
Source: Antonie van Leeuwenhoek - August 3, 2014 Category: Microbiology Authors: Zhang G, Yang Y, Yin X, Wang S Tags: Antonie Van Leeuwenhoek Source Type: research

[Comment] Decisive action to end apathy and achieve 25×25 NCD targets
In 1990, an estimated 26·6 million people worldwide died from non-communicable diseases (NCDs). By 2010, NCDs accounted for 34·5 million deaths (66% of total deaths) globally—the leading cause of death in all regions except sub-Saharan Africa and south Asia, with 28·3 million deaths from cardiovascular and chronic respiratory diseases, cancers, and diabetes. (Source: LANCET)
Source: LANCET - August 2, 2014 Category: Journals (General) Authors: Rifat Atun Tags: Comment Source Type: research

Association between infant swimming and rhinovirus‐induced wheezing
ConclusionThere may be a link between infant swimming and rhinovirus‐induced wheezing illnesses in atopic infants. (Source: Acta Paediatrica)
Source: Acta Paediatrica - August 2, 2014 Category: Pediatrics Authors: Linnea Schuez‐Havupalo, Sinikka Karppinen, Laura Toivonen, Anne Kaljonen, Tuomas Jartti, Matti Waris, Ville Peltola Tags: Regular Article Source Type: research

Evidence of mycobacterial disease in COPD patients with lung volume reduction surgery; the importance of histological assessment of specimens: a cohort study
Conclusion: A proportion of severe COPD patients will have evidence of mycobacterial infection despite lack of clinical and radiological suspicion. This may have implications for long-term management of these patients. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - August 2, 2014 Category: Respiratory Medicine Authors: Anjali CharNick HopkinsonDavid HansellAndrew NicholsonEmily ShawSamuel ClarkPhilip SedgwickRobert WilsonSimon JordanMichael Loebinger Source Type: research

Congenital and Uncorrected Rotoscoliosis resulting in Restrictive Lung Disease and Respiratory Failure
We report a case of uncorrected rotoscoliosis since childhood presenting with dyspnea and respiratory failure. CT scan of the chest demonstrated the severity of rotoscoliosis as noted on selected images. (Source: The Spine Journal)
Source: The Spine Journal - August 2, 2014 Category: Orthopaedics Authors: Mouhamad Nasser, Bassem Y. Tanios, Ahmad Husari Source Type: research

TLR4 activation induces IL-1ß release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung
Conclusions: TLR4 activation increases levels of BALF IL-1b/IL-18 via an IPAF dependent and caspase 1/11/8 independent pathway. Furthermore, it would appear that the presence of IL-1a in the BALF is independent of these pathways. This novel data sheds light on innate signalling pathways in the lung that control the production of these key inflammatory cytokines. (Source: Respiratory Research)
Source: Respiratory Research - August 2, 2014 Category: Respiratory Medicine Authors: Suffwan EltomMaria BelvisiLiang Yew-BoothBilel DekkakSarah MaherEric DubuisVictoria JonesKate FitzgeraldMark Birrell Source Type: research

John B. Barlow: The Man and His Syndrome
Six years ago the world was saddened by the death of John Brereton Barlow of the Barlow syndrome of mitral valve prolapse [1]. He died from respiratory failure on December 10, 2008 in Johannesburg, South Africa at the age of eighty four. He will be remembered fondly by his peers and missed dearly by his patients. I for one will never forget him as my best and close friend, an intimate colleague, a trusted confidant, a pioneer in evidence-based medicine, a sharp-minded and energetic physician, a master clinician, and a compleat cardiologist [2,3]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 2, 2014 Category: Cardiology Authors: Tsung O. Cheng Source Type: research

Factors predicting future ACS episodes in children with sickle cell anemia
Abstract While a doctor‐diagnosis of asthma is associated with an increased risk of pain and acute chest syndrome (ACS) in children with sickle cell anemia (SCA), little is known about the relationship between specific asthma characteristics and clinical factors and future morbidity in children with SCA. We evaluated the relationship between 1) asthma risk factors at the time of a clinical visit (respiratory symptoms, maternal history of asthma, allergy skin tests, spirometry results) and 2) the known risk factor of ACS early in life, on prospective pain and ACS episodes in a cohort of 159 children with SCA followed from...
Source: American Journal of Hematology - August 2, 2014 Category: Hematology Authors: Michael R. DeBaun, Mark Rodeghier, Robyn Cohen, Fenella J. Kirkham, Carol L. Rosen, Irene Roberts, Ben Cooper, Janet Stocks, Olu Wilkey, Baba Inusa, John O. Warner, Robert C. Strunk Tags: Research Article Source Type: research

Siansivirga jejunensis sp. nov., isolated from seawater of Jeju Island in Korea and emendation of the genus Siansivirga.
Abstract A Gram-stain negative, non-flagellated, non-gliding and rod-shaped bacterium, strain JHH-2(T), was isolated from seawater collected in Jeju Island, Korea. The novel isolate was found to grow at 25-30 °C, at pH 6.5-7.0 and in the presence of 1-2 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain JHH-2(T) is closely related to Siansivirga zeaxanthinifaciens JCM 17682(T), with 16S rRNA gene sequence similarity of 96.6 %. The predominant respiratory quinone was identified as menaquinone-6 and the major cellular fatty acids were detected as iso-C15:0, C16:0 and iso-C17...
Source: Antonie van Leeuwenhoek - August 2, 2014 Category: Microbiology Authors: Park JM, Han SK, Lee DG, Kang H, Trujillo ME, Lee DK Tags: Antonie Van Leeuwenhoek Source Type: research

CORONAVIRUS VIRULENCE GENES WITH MAIN FOCUS ON SARS-CoV ENVELOPE GENE.
Abstract Coronavirus (CoV) infection is usually detected by cellular sensors, which trigger the activation of the innate immune system. Nevertheless, CoVs have evolved viral proteins that target different signaling pathways to counteract innate immune responses. Some CoV proteins act as antagonists of interferon (IFN) by inhibiting IFN production or signaling, aspects that are briefly addressed in this review. After CoV infection, potent cytokines relevant in controlling virus infections and priming adaptive immune responses are also generated. However, an uncontrolled induction of these proinflammatory cytokines c...
Source: Virus Research - August 2, 2014 Category: Virology Authors: DeDiego ML, Nieto-Torres JL, Jimenez-Guardeño JM, Regla-Nava JA, Castaño-Rodriguez C, Fernandez-Delgado R, Usera F, Enjuanes L Tags: Virus Res Source Type: research

A promoter mutation in the haemagglutinin segment of influenza A virus generates an effective candidate live attenuated vaccine
ConclusionsWe demonstrate that NIBRG‐93 is an effective live attenuated vaccine virus protecting mice against lethal challenge and reducing virus shedding. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - August 2, 2014 Category: Infectious Diseases Authors: Ruth Harvey, Rachel E. Johnson, Kirsty MacLellan‐Gibson, James S. Robertson, Othmar G. Engelhardt Tags: Original Article Source Type: research

A monoclonal antibody‐based immunoassay for measuring the potency of 2009 pandemic influenza H1N1 vaccines
ConclusionsThis study demonstrates the general feasibility of the mAb approach and strongly suggests that such ELISAs have potential for continued development as an alternative method to assay the potency of inactivated influenza vaccines. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - August 2, 2014 Category: Infectious Diseases Authors: Falko Schmeisser, Anupama Vasudevan, Jackeline Soto, Arunima Kumar, Ollie Williams, Jerry P. Weir Tags: Original Article Source Type: research

Anti-ETR and anti-ATR autoantibodies are elevated in patients with endstage cystic fibrosis
Autoantibodies against endothelin-1 type A receptor (ETAR) are present in systemic sclerosis complicated by lung fibrosis and pulmonary hypertension. As increased serum levels and local overproduction of endothelin-1 in the airways are reported in cystic fibrosis (CF) patients, we reasoned that anti-ETAR antibodies could be prevalent in endstage CF patients prior to lung transplantation (LTx). Also, ETAR autoantibodies are frequently associated with autoantibodies against the angiotensin II type 1 receptor (AT1R). (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - August 2, 2014 Category: Respiratory Medicine Authors: K. Budding, E.A. van de Graaf, T. Hoefnagel, J.M. Kwakkel-van Erp, D.A. van Kessel, D. Dragun, C.E. Hack, H.G. Otten Source Type: research

Drug Delivery to Paranasal Sinuses Using Pulsating Aerosols
Journal of Aerosol Medicine and Pulmonary Drug Delivery Aug 2014, Vol. 27, No. 4: 255-263. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - August 1, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Comments Regarding the Article: “Design of Aerosol Face Masks for Children Using Computerized 3D Face Analysis”
Journal of Aerosol Medicine and Pulmonary Drug Delivery Aug 2014, Vol. 27, No. 4: 313-313. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - August 1, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Diagnostic Performance of ST2 for Differentiating Cardiogenic versus Non-Cardiogenic Pulmonary Edema in Patients Presenting to the Intensive Care Unit with Hypoxic Respiratory Failure
ST2 is an interleukin receptor that is upregulated in response to myocardial strain, has a circulating form, and has prognostic value in acute dyspnea and heart failure. The utility of ST2 for predicting invasive hemodynamics and differentiating the cause of hypoxic respiratory failure between cardiogenic pulmonary edema (CPE) and acute respiratory distress syndrome (ARDS) is unknown. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2014 Category: Cardiology Authors: E. Wilson Grandin, Ajay J. Kirtane, Dimitrios Karmapaliotis, Petr Jarolim, Sarah Sloan, Richard T. Lee, David A. Morrow Tags: Neurohormones/Cytokines I Source Type: research

Rapid Shallow Breathing Worsens Prior to Heart Failure Decompensation
Respiratory distress is one of the primary drivers for heart failure (HF) hospitalization. Respiratory rate (RR) and minute ventilation (MV), as monitored by implanted devices, have demonstrated changes leading to admissions. Since patients often present with rapid shallow breathing, we hypothesize that a rapid shallow breathing index (RSBI) will better reflect respiratory distress than either RR or MV. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - August 1, 2014 Category: Cardiology Authors: Alessandro Capucci, Giulio Molon, Michael R. Gold, Yi Zhang, Robert Sweeney, Viktoria Averina, John P. Boehmer Tags: Rapid-Fire Abstracts II Source Type: research

Respiratory pump contributes to increased physiological reserve for compensation during simulated haemorrhage
New Findings What is the central question of this study? The negative intrathoracic pressure created by inspiration (i.e. the respiratory pump) is associated with enhanced venous return, although its contribution as a potential mechanism of compensation during blood loss has not been quantified. What is the main finding and its importance? We demonstrated that optimizing the creation of negative intrathoracic pressure during inspiration represented a mechanism of compensation during haemorrhage that was quantifiably reflected in a reduced rate of diminution of the compensatory reserve, resulting in increased tolerance to p...
Source: Experimental Physiology - August 1, 2014 Category: Physiology Authors: Paula Y. S. Poh, Robert Carter, Carmen Hinojosa‐Laborde, Jane Mulligan, Gregory Z. Grudic, Victor A. Convertino Tags: Research Paper Source Type: research

The Epidemiology and Aetiology of Infections in Children Admitted with Clinical Severe Pneumonia to a University Hospital in Rabat, Morocco
Conclusions: In Morocco, the epidemiological profile of paediatric acute respiratory infections is markedly shifted towards wheezing-related diseases and thus resembles that of high-income countries. However, the high associated CFRs found in this study call for an improvement in preventive and clinical management strategies. (Source: Journal of Tropical Pediatrics)
Source: Journal of Tropical Pediatrics - August 1, 2014 Category: Tropical Medicine Authors: Jroundi, I., Mahraoui, C., Benmessaoud, R., Moraleda, C., Tligui, H., Seffar, M., Kettani, S. C., Benjelloun, B. S., Chaacho, S., Maaroufi, A., Hayes, E. B., Alvarez-Martinez, M. J., Munoz-Almagro, C., Ruiz, J., Alonso, P. L., Bassat, Q. Tags: Original Papers Source Type: research