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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

The Effect of Different Exercise Modalities on Dyspnea and Leg Fatigue in Healthy Subjects
Conclusion These findings indicate that at equivalent levels of cardiopulmonary stress reflected by similar levels of V̇O2 and heart rate, the perceived level of exertional dyspnea is not influenced by different patterns of neuromuscular activity. Similarly, the intensity of leg fatigue primarily reflects whole body work and is independent of different patterns of neuromuscular activity. (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - February 16, 2015 Category: Respiratory Medicine Source Type: research

Harsh parenting, parasympathetic activity, and development of delinquency and substance use.
Stress response systems are thought to play an important role in the development of psychopathology. In addition, family stress may have a significant influence on the development of stress response systems. One potential avenue of change is through alterations to thresholds for the activation of stress responses: Decreased threshold for responding may mark increased stress sensitivity. Our first aim was to evaluate the interaction between thresholds for parasympathetic nervous system (PNS) responding, operationalized as resting respiratory sinus arrhythmia (RSA), and harsh parenting in the prediction of development of del...
Source: Journal of Abnormal Psychology - February 16, 2015 Category: Psychiatry & Psychology Authors: Hinnant, J. Benjamin; Erath, Stephen A.; El-Sheikh, Mona Source Type: research

Loop diuretics for patients receiving blood transfusions.
CONCLUSIONS: There was insufficient evidence to determine whether premedicating people undergoing blood transfusion with loop diuretics prevents clinically important transfusion-related morbidity. Due to the continued use of prophylactic loop diuretics during transfusions, and because this review highlights the absence of evidence to justify this practice, well-conducted RCTs are needed. Given the high mortality, severe morbidity and increasing incidence of transfusion-associated circulatory overload, determining the therapeutic utility of pre-transfusion loop diuresis is an urgent need. PMID: 25685898 [PubMed - as sup...
Source: Cochrane Database of Systematic Reviews - February 16, 2015 Category: Journals (General) Authors: Sarai M, Tejani AM Tags: Cochrane Database Syst Rev Source Type: research

Be honest and help me prepare for the future: What people with interstitial lung disease want from education in pulmonary rehabilitation.
This study explored the perspectives of patients and ILD clinicians regarding the educational content of PR for ILD. A qualitative study using individual semi-structured interviews was undertaken. Transcripts were coded independently by two investigators and themes established by consensus. Participants were 18 people with ILD (9 idiopathic pulmonary fibrosis, diffusing capacity for carbon monoxide 54 (20)% predicted) and 14 clinicians from 5 countries and 5 disciplines. Major themes from patient interviews were the importance of knowing what the future might bring and the need for honesty from clinicians. Most were happy ...
Source: Chronic Respiratory Disease - February 16, 2015 Category: Respiratory Medicine Authors: Holland AE, Fiore JF, Goh N, Symons K, Dowman L, Westall G, Hazard A, Glaspole I Tags: Chron Respir Dis Source Type: research

Adoption of Preventive Behaviors in Response to the 2009 H1N1 Influenza Pandemic: A Multiethnic Perspective.
CONCLUSIONS: Minority groups appear to be receptive to several preventive behaviors, but barriers to vaccination are more pervasive. This article is protected by copyright. All rights reserved. PMID: 25688806 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - February 16, 2015 Category: Respiratory Medicine Authors: SteelFisher GK, Blendon RJ, Kang M, Ward JR, Kahn EB, Maddox KE, Lubell KM, Tucker M, Ben-Porath EN Tags: Influenza Other Respir Viruses Source Type: research

Genetic conjugation of components in two pneumococcal fusion protein vaccines enhances paediatric mucosal immune responses.
Abstract Streptococcus pneumoniae colonises the upper respiratory tract and can cause pneumonia, meningitis and otitis media. Existing pneumococcal conjugate vaccines are expensive to produce and only protect against 13 of the 90+ pneumococcal serotypes; hence there is an urgent need for the development of new vaccines. We have shown previously in mice that pneumolysin (Ply) and a non-toxic variant (Δ6Ply) enhance antibody responses when genetically fused to pneumococcal surface adhesin A (PsaA), a potentially valuable effect for future vaccines. We investigated this adjuvanticity in human paediatric mucosal prima...
Source: Vaccine - February 16, 2015 Category: Allergy & Immunology Authors: Pope C, Oliver EH, Ma J, Hewer CL, Mitchell TJ, Finn A Tags: Vaccine Source Type: research

Drug related serious bradycardia
Kawabata M, Yokoyama Y, Sasaki T, Tao S, Ihara K, Shirai Y, Sasano T, Goya M, Furukawa T, Isobe M, Hirao K (Source: International Journal of COPD)
Source: International Journal of COPD - February 15, 2015 Category: Respiratory Medicine Source Type: research

Extra-pulmonary tuberculosis and Xpert® MTB/RIF: all about meta-analyses?
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: O'Grady, JustinKik, Sandra V.Ferrara, Giovanni Tags: EDITORIALS Source Type: research

To improve our tuberculosis burden estimates we need to learn from each other
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Houben, Rein M. G. J.White, Richard G. Tags: EDITORIALS Source Type: research

On the virulence and specificity of tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Villemin, Dr J. A. Tags: FOUNDERS OF OUR KNOWLEDGE Source Type: research

Jean-Antoine Villemin and the infectious nature of tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Daniel, Thomas M. Tags: FOUNDERS OF OUR KNOWLEDGE Source Type: research

Tuberculosis contact investigation in low- and middle-income countries: standardized definitions and indicators
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Fair, E.Miller, C. R.Ottmani, S-E.Fox, G. J.Hopewell, P. C. Tags: PERSPECTIVES Source Type: research

The complexities of Xpert® MTB/RIF interpretation
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Lippincott, C. K.Miller, M. B.Van Rie, A.Weber, D. J.Sena, A. C.Stout, J. E. Tags: ORIGINAL ARTICLES Source Type: research

Appropriate use of the Xpert® MTB/RIF assay in suspected tuberculous meningitis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Boyles, T. H.Thwaites, G. E. Tags: ORIGINAL ARTICLES Source Type: research

Diagnostic accuracy of the Xpert® MTB/RIF assay for extra-pulmonary tuberculosis: a meta-analysis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Penz, E.Boffa, J.Roberts, D. J.Fisher, D.Cooper, R.Ronksley, P. E.James, M. T. Tags: ORIGINAL ARTICLES Source Type: research

The impact of Xpert® MTB/RIF depends on service coordination: experience in Burkina Faso
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Moyenga, I.Roggi, A.Sulis, G.Diande, S.Tamboura, D.Tagliani, E.Castelli, F.Matteelli, A. Tags: ORIGINAL ARTICLES Source Type: research

An approach to estimating tuberculosis incidence and case detection rate from routine notification data
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Avilov, K. K.Romanyukha, A. A.Borisov, S. E.Belilovsky, E. M.Nechaeva, O. B.Karkach, A. S. Tags: ORIGINAL ARTICLES Source Type: research

Six- vs. eight-month anti-tuberculosis regimen for pulmonary tuberculosis under programme conditions
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Ukwaja, K. N.Oshi, S. N.Alobu, I.Oshi, D. C. Tags: ORIGINAL ARTICLES Source Type: research

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Mave, V.Chandanwale, A.Bhosale, R.Shere, D.Gupte, N.Suryavanshi, N.Kulkarni, V.Kagal, A.Bharadwaj, R.Joshi, S.Bollinger, R. C.Gupta, A.for the SWEN (Six Weeks Extended Nevirapine India) and Byramjee-Jeejeebhoy Medical College Clinical Trials Unit Study te Tags: ORIGINAL ARTICLES Source Type: research

Risk of cataract for people with tuberculosis: results from a population-based cohort study
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Hsia, N-Y.Ho, Y-H.Shen, T-C.Lin, C-L.Huang, K-Y.Chen, C-H.Tu, C-Y.Shih, C-M.Hsu, W-H.Sung, F-C. Source Type: research

Permanent employment or public assistance may increase tuberculosis survival among working-age patients in Japan
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Uchimura, K.Ngamvithayapong-Yanai, J.Kawatsu, L.Ohkado, A.Yoshiyama, T.Ito, K.Ishikawa, N. Tags: ORIGINAL ARTICLES Source Type: research

MTBDRplus results correlate with treatment outcome in previously treated tuberculosis patients
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Huang, F-L.Jin, J-L.Chen, S.Zhou, Z.Diao, N.Huang, H-Q.Liu, W.Wang, Q.Weng, X-H.Chaisson, R. E.Zhang, Y.Zhang, W-H. Tags: ORIGINAL ARTICLES Source Type: research

A randomized trial comparing standard outcomes in two treatment models for substance users with tuberculosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Ricks, P. M.Hershow, R. C.Rahimian, A.Huo, D.Johnson, W.Prachand, N.Jimenez, A.Wiebel, W.Paul, W. Tags: ORIGINAL ARTICLES Source Type: research

Bioequivalence of fixed-dose combination RIN®-150 to each reference drug in loose combination
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Wang, H. F.Wang, R.O'Gorman, M.Crownover, P.Damle, B. Tags: ORIGINAL ARTICLES Source Type: research

Concordance of Mycobacterium tuberculosis fluoroquinolone resistance testing: implications for treatment
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Farhat, M. R.Mitnick, C. D.Franke, M. F.Kaur, D.Sloutsky, A.Murray, M.Jacobson, K. R. Tags: ORIGINAL ARTICLES Source Type: research

Comparison of LTBI treatment regimens for patients receiving anti-tumour necrosis factor therapy
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Park, S-J.Jo, K-W.Yoo, B.Lee, C-K.Kim, Y-G.Yang, S-K.Byeon, J-S.Kim, K-J.Ye, B. D.Park, S-H.Shim, T. S. Tags: ORIGINAL ARTICLES Source Type: research

The effect of exposure to wood smoke on outcomes of childhood pneumonia in Botswana
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Kelly, M. S.Wirth, K. E.Madrigano, J.Feemster, K. A.Cunningham, C. K.Arscott-Mills, T.Boiditswe, S.Shah, S. S.Finalle, R.Steenhoff, A. P. Tags: ORIGINAL ARTICLES Source Type: research

Bronchoscope insertion route and patient comfort during flexible bronchoscopy
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Aguirre, J. E. GonzálezMartínez, U. ChavarríaMier, D. RodríguezMoreno, M. AcostaLongoria, R. Mercado Tags: ORIGINAL ARTICLES Source Type: research

Two case reports of Castleman disease with pulmonary involvement
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Zhang, H.Zhang, J-Q.Zhong, X-N.Liu, G-N.Li, M-H.Bai, J.He, Z-Y.Deng, J-M. Tags: CASE STUDY Source Type: research

In reply to ‘False-positive Xpert® MTB/RIF assays in previously treated patients'
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Steingart, Karen R.Schiller, IanDendukuri, NandiniLalli, MarekHouben, ReinChurchyard, GavinWhite, Richard G.Hoger, SallyLykens, KristineBeavers, SuzanneKatz, DollyMiller, ThaddeusVerma, SantwanaVerma, GhanshyamSingh, Dig VijayMokta, JitenderNegi, Rameshwa Tags: CORRESPONDENCE Source Type: research

Modeling and measurement of the variations of CT number distributions for mobile targets in cone-beam computed tomographic imaging.
Abstract The purpose of this study was to investigate quantitatively by measurement and modeling the variations in CT number distributions of mobile targets in cone-beam CT (CBCT) imaging. CBCT images were acquired for three targets manufactured from homogenous water-equivalent gel that was inserted into a commercial mobile thorax phantom. The phantom moved with a controlled cyclic motion in one-dimension along the superior-inferior direction to simulate patient respiratory motion. Profiles of the CT number distributions of the static and mobile targets were obtained using CBCT images. A mathematical model was deve...
Source: Journal of Applied Clinical Medical Physics - February 15, 2015 Category: Physics Authors: Ali I, Alsbou N, Ahmad S Tags: J Appl Clin Med Phys Source Type: research

Development of system using beam's eye view images to measure respiratory motion tracking errors in image-guided robotic radiosurgery system.
Abstract The accuracy of the CyberKnife Synchrony Respiratory Tracking System (SRTS) is considered to be patient-dependent because the SRTS relies on an individual correlation between the internal tumor position (ITP) and the external marker position (EMP), as well as a prediction method to compensate for the delay incurred to adjust the position of the linear accelerator (linac). We aimed to develop a system for obtaining pretreatment statistical measurements of the SRTS tracking error by using beam's eye view (BEV) images, to enable the prediction of the patient-specific accuracy. The respiratory motion data for ...
Source: Journal of Applied Clinical Medical Physics - February 15, 2015 Category: Physics Authors: Inoue M, Shiomi H, Iwata H, Taguchi J, Okawa K, Kikuchi C, Inada K, Iwabuchi M, Murai T, Koike I, Tatewaki K, Ohta S, Inoue T Tags: J Appl Clin Med Phys Source Type: research

Postoperative Oxycodone Toxicity in a Patient with Chronic Pain and End-Stage Renal Disease
We present this case to review the metabolism of oxycodone and the effects of end-stage renal disease on the elimination of oxycodone and its metabolites. A 42-year-old female with end-stage renal disease who was dependent on hemodialysis presented for left hamstring posterior capsule release. She had been receiving methadone for 2 years for chronic leg pain. On postoperative day 1, the patient’s medication was changed from IV hydromorphone to oral oxycodone to treat breakthrough pain. By the next day, the patient was unarousable with notable respiratory depression. She did not fully recover after urgent hemodialysis but...
Source: A&A Case Reports - February 15, 2015 Category: Anesthesiology Tags: Case Reports: Case Report Source Type: research

Laryngeal Muscle Activity during Nasal High-Frequency Oscillatory Ventilation in Nonsedated Newborn Lambs.
CONCLUSION: nHFOV does not induce glottal constrictor muscle EMG in nonsedated newborn lambs, in contrast to nPSV. This may be an additional advantage of nHFOV relative to nPSV. © 2015 S. Karger AG, Basel. PMID: 25660143 [PubMed - in process] (Source: Neonatology)
Source: Neonatology - February 15, 2015 Category: Perinatology & Neonatology Authors: Hadj-Ahmed MA, Samson N, Nadeau C, Boudaa N, Praud JP Tags: Neonatology Source Type: research

Respiratory arrest caused by accidental rapid pralidoxime infusion
Clinical Toxicology, Ahead of Print. (Source: Clinical Toxicology)
Source: Clinical Toxicology - February 15, 2015 Category: Toxicology Tags: article Source Type: research

Emergency escape surgery for a gastro-bronchial fistula with respiratory failure that developed after esophagectomy
Abstract A gastro-bronchial fistula (GBF) is a rare complication after esophageal reconstruction using a gastric tube, but it can cause severe pneumonia, and the surgical procedure is challenging. We herein describe a patient who was successfully managed using a two-stage operation for a GBF. Because the patient had life-threatening pneumonia and respiratory failure caused by the GBF, we first transected the duodenum, established a cervical esophagostomy and gastrostomy and placed a decompression catheter in the gastric tube without a thoracotomy. The patient recovered from pneumonia after the resolution of t...
Source: Surgery Today - February 15, 2015 Category: Surgery Source Type: research

Effects of rapid maxillary expansion and mandibular advancement on upper airways in Marfan’s syndrome children: a home sleep study and cephalometric evaluation
Conclusions Early rapid maxillary expansion and mandibular advancement using Propulsor Universal Light appliance significantly improved airway patency of Marfan’s syndrome children and are strongly encouraged as a routine treatment for both correction of class II malocclusions and prevention of obstructive sleep apnea. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 15, 2015 Category: Respiratory Medicine Source Type: research

Suitability of sentinel abattoirs for syndromic surveillance using provincially inspected bovine abattoir condemnation data
Conclusions: Sentinel abattoirs show promise for integration into a food animal syndromic surveillance system using Ontario provincial abattoir condemnation data. While all selection approaches tended to overestimate the condemnation rates of the full dataset to some degree, the abattoirs open all weeks selection approach appeared to best capture the overall seasonal and temporal trends of the full dataset and would be the most suitable approach for sentinel abattoir selection. (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - February 15, 2015 Category: Veterinary Research Authors: Gillian AltonDavid PearlKen BatemanW McNabOlaf Berke Source Type: research

Clinical and antiviral effect of a single oral dose of famciclovir administered to cats at intake to a shelter
Publication date: February 2015 Source:The Veterinary Journal, Volume 203, Issue 2 Author(s): A.L. Litster , B.R. Lohr , R.A. Bukowy , S.M. Thomasy , D.J. Maggs Although famciclovir is efficacious in feline herpesvirus type 1 (FHV-1)-infected cats, effects of a single dose early in disease course have not been reported. In this two part, randomized, masked, placebo controlled study, cats received a single dose of 125 mg famciclovir (n = 43) or placebo (n = 43; pilot study), or 500 mg famciclovir (n = 41) or placebo (n = 40; clinical trial) on entering a shelter. FHV-1 PCR testing was performed, bodywe...
Source: The Veterinary Journal - February 15, 2015 Category: Veterinary Research Source Type: research

Human anelloviruses: an update of molecular, epidemiological and clinical aspects
Abstract Human torque teno viruses (TTVs) are new, emerging infectious agents, recently assigned to the family Anelloviridae. The first representative of the genus, torque teno virus (TTV), was discovered in 1997, followed by torque teno mini virus (TTMV) in 2000, and torque teno midi virus (TTMDV) in 2007. These viruses are characterized by an extremely high prevalence, with relatively uniform distribution worldwide and a high level of genomic heterogeneity, as well as an apparent pan-tropism at the host level. Although these viruses have a very high prevalence in the general population across the globe, neither ...
Source: Archives of Virology - February 15, 2015 Category: Virology Source Type: research

The influence of extracorporeal membrane oxygenation therapy on intestinal mucosal barrier in a porcine model for post-traumatic acute respiratory distress syndrome
Background: It is unclear at present whether extracorporeal membrane oxygenation (ECMO) therapy can improve intestinal mucous barrier function through increased perfusion. The present study establishes an animal model for post-traumatic acute respiratory distress syndrome (ARDS) and evaluates the effect of v-vECMO treatment on the intestinal mucosal barrier.MethodPulmonary contusion combined with ischemia-reperfusion injury was induced in 30 piglets. The animals were randomly divided into control, model, and ECMO groups. Serum I-FABP, d-lactate, and endotoxin were measured over a 24-h period. The jejunum and colon were col...
Source: Journal of Cardiothoracic Surgery - February 15, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Ling NiQiyi ChenKe ZhuJialiang ShiJuanhong ShenJianfeng GongTao gaoWenkui YuJieshou LiNing Li Source Type: research

Etiology of community-acquired pneumonia and diagnostic yields of microbiological methods: a 3-year prospective study in Norway
Background: Despite recent advances in microbiological techniques, the etiology of community-acquired pneumonia (CAP) is still not well described. We applied polymerase chain reaction (PCR) and conventional methods to describe etiology of CAP in hospitalized adults and evaluated their respective diagnostic yields. Methods: 267 CAP patients were enrolled consecutively over our 3-year prospective study. Conventional methods (i.e., bacterial cultures, urinary antigen assays, serology) were combined with nasopharyngeal (NP) and oropharyngeal (OP) swab samples analyzed by real-time quantitative PCR (qPCR) for Streptococcus pneu...
Source: BMC Infectious Diseases - February 15, 2015 Category: Infectious Diseases Authors: Jan HolterFredrik MüllerOla BjørangHelvi SamdalJon MarthinsenPål JenumThor UelandStig FrølandPål AukrustEinar HusebyeLars Heggelund Source Type: research

Early right ventricular fibrosis and reduction in biventricular cardiac reserve in the dystrophin-deficient mdx heart
Duchenne muscular dystrophy (DMD) is a progressive disease of striated muscle deterioration. Respiratory and cardiac muscle dysfunction are particularly clinically relevant because they result in the leading causes of death in DMD patients. Despite the clinical and physiological significance of these systems, little has been done to understand the cardiorespiratory interaction in DMD. We show here that prior to the onset of global cardiac dysfunction, dystrophin-deficient mdx mice have increased cardiac fibrosis with the right ventricle being particularly affected. Using a novel biventricular cardiac catheterization techni...
Source: AJP: Heart and Circulatory Physiology - February 15, 2015 Category: Cardiology Authors: Meyers, T. A., Townsend, D. Tags: MUSCLE MECHANICS AND VENTRICULAR FUNCTION Source Type: research

Ebola: history, treatment, and lessons from a new emerging pathogen
(Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Harrod, K. S. Tags: CALL FOR PAPERS Source Type: research

Vasculopathy and pulmonary hypertension in sickle cell disease
Sickle cell disease (SCD) is an autosomal recessive disorder in the gene encoding the β-chain of hemoglobin. Deoxygenation causes the mutant hemoglobin S to polymerize, resulting in rigid, adherent red blood cells that are entrapped in the microcirculation and hemolyze. Cardinal features include severe painful crises and episodic acute lung injury, called acute chest syndrome. This population, with age, develops chronic organ injury, such as chronic kidney disease and pulmonary hypertension. A major risk factor for developing chronic organ injury is hemolytic anemia, which releases red blood cell contents into the cir...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Potoka, K. P., Gladwin, M. T. Tags: PHYSIOLOGY IN MEDICINE Source Type: research

ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets
Acute and chronic lung inflammation is driven and controlled by several endogenous mediators that undergo proteolytic conversion from surface-expressed proteins to soluble variants by a disintegrin and metalloproteinase (ADAM)-family members. TNF and epidermal growth factor receptor ligands are just some of the many substrates by which these proteases regulate inflammatory or regenerative processes in the lung. ADAM10 and ADAM17 are the most prominent members of this protease family. They are constitutively expressed in most lung cells and, as recent research has shown, are the pivotal shedding enzymes mediating acute lung...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Dreymueller, D., Uhlig, S., Ludwig, A. Tags: CALL FOR PAPERS Source Type: research