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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

Hospital Resource Utilization and Patient Outcomes Associated with Respiratory Viral Testing in Hospitalized Patients
S. Mulpuru et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - June 19, 2015 Category: Infectious Diseases Source Type: research

Acute Respiratory Infections in Travelers Returning from MERS-CoV–Affected Areas
M. German et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - June 19, 2015 Category: Infectious Diseases Source Type: research

MEGDEL Syndrome in a Child From Palestine: Report of a Novel Mutation in SERAC1 Gene
This report further expands the genetic spectrum of MEGDEL syndrome and adds to the evidence that it is associated with variable patterns of respiratory chain abnormalities. (Source: Journal of Child Neurology)
Source: Journal of Child Neurology - June 19, 2015 Category: Neurology Authors: Dweikat, I. M., Abdelrazeq, S., Ayesh, S., Jundi, T. Tags: Brief Communication Source Type: research

Long-term effects of childhood chest infections
As paediatricians we are sometimes guilty of underestimating the possible consequences in adult life of common childhood illnesses. Children with acute lower respiratory infections (LRIs) are usually treated and discharged, with full reassurance that their lungs will subsequently be normal. However the findings of a very long-term follow-up cohort study from Tucson, Arizona are far from reassuring (Chan JC, et al. Pediatrics 2015:135;607–616). Around 1240 children born between 1980 and 1984 were followed up with spirometry and symptom questionnaires at intervals to age 29 years. Data had already been gathered on occu...
Source: Archives of Disease in Childhood - June 19, 2015 Category: Pediatrics Tags: Miscellanea Source Type: research

Using multifaceted education to improve management in acute viral bronchiolitis
Conclusions This audit demonstrated a significant improvement in compliance following implementation of our educational bundle. This has enabled improvement in standardised and evidence-based patient care across Wales. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - June 19, 2015 Category: Pediatrics Authors: Murch, H., Oakley, J., Pierrepoint, M., Powell, C., Fountain-Polley, Mustafa, Stutchfield, Ingley, Sridhar, Oo, Pollock, Pepperman, Owen, Nasef, Behery, Maderazo, Evans, Foulkes, Patwardhan, Fernandes, Hanks, Broomfield, Carnell, Munaf, Vaswani, Lewis, Wo Tags: Patients, Bronchiolitis, TB and other respiratory infections, Bronchitis, Clinical diagnostic tests Quality improvement Source Type: research

Question 2: Should 0.9% saline be used for maintenance fluids in hospitalised children?
Scenario A 6-year-old boy with severe tonsillitis requires intravenous maintenance fluids. As a new specialist registrar to this hospital you are unfamiliar with their fluid policy. The nurse informs you that the routine intravenous solution used is 0.45% sodium chloride with 5% dextrose. This is not what you are familiar with having previously used 0.9% sodium chloride with 5% dextrose. You are unsure what the evidence for isotonic versus hypotonic fluid is in children requiring intravenous maintenance fluids, in particular the effect on serum sodium. Structured clinical question In hospitalised children requiring intrave...
Source: Archives of Disease in Childhood - June 19, 2015 Category: Pediatrics Authors: Morgan, J. A. Tags: ADC Archimedes, Patients, Pneumonia (infectious disease), TB and other respiratory infections, Epilepsy and seizures, Infection (neurology), Childhood nutrition, Reproductive medicine, Child health, Infant nutrition (including breastfeeding), Adult intens Source Type: research

Interventional Therapeutic Strategy for Hemoptysis Originating from Infectious Pulmonary Artery Pseudoaneurysms
This study reports 6 cases of hemoptysis originating from infectious pulmonary artery pseudoaneurysms (PAPs). Selective pulmonary angiography revealed PAPs in 5 cases, and segmental pulmonary artery embolization was performed using coils and gelatin sponge particles. Systemic arterial embolization also was performed in 5 cases because of inadequate initial control or for shunts from systemic to pulmonary arteries. At a median follow-up time of 9 months (range, 25 d to 25 mo), no recurrence occurred, although 2 patients died of respiratory failure. Segmental artery embolization combined with systemic artery embolization may...
Source: Journal of Vascular and Interventional Radiology - June 19, 2015 Category: Radiology Source Type: research

Aetiology and clinical characteristics of patients with bronchiectasis in a Chinese Han population: A prospective study
ConclusionsIn a Chinese Han population in Shandong, idiopathic bronchiectasis is the most common form of bronchiectasis followed by post‐tuberculosis bronchiectasis. Patients with different causes differ in distribution and pattern of bronchiectasis on computed tomography. (Source: Respirology)
Source: Respirology - June 19, 2015 Category: Respiratory Medicine Authors: Qian Qi, Wen Wang, Tao Li, Yan Zhang, Yu Li Tags: Original Article Source Type: research

A prediction model based on artificial neural networks for the diagnosis of obstructive sleep apnea
Conclusions By establishing a pattern that allows the recognition of OSA, ANNs can be used to identify patients requiring PSG. (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 19, 2015 Category: Respiratory Medicine Source Type: research

6-Mercaptopurine reduces cytokine and Muc5ac expression involving inhibition of NFκB activation in airway epithelial cells
Conclusions: Our data demonstrate that 6-MP inhibits Muc5ac gene expression and mucus production in airway epithelial cells through inhibition of the NFκB pathway, and 6-MP may represent a novel therapeutic target for mucus hypersecretion in airway diseases. (Source: Respiratory Research)
Source: Respiratory Research - June 19, 2015 Category: Respiratory Medicine Authors: Kondababu KurakulaAnouk HamersPieter van LoenenCarlie de Vries Source Type: research

Serum zinc concentration in cystic fibrosis patients with CFTR I1234V mutation associated with pancreatic sufficiency
Conclusion: These findings suggest that Zn deficiency can occur in CF patients with PS. The association of Zn levels and the frequency of P. aeruginosa isolated in CF patients need further investigation This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - June 19, 2015 Category: Respiratory Medicine Authors: Atqah AbdulWahab, Ahmed Abushahin, Mona Allangawi, Prem Chandra, Mohamed Osman AbdelRahman, Ashraf Soliman Tags: Original Article Source Type: research

Atelectasis causes alveolar hypoxia-induced inflammation during uneven mechanical ventilation in rats
Conclusions: Atelectasis causes alveolar hypoxia-induced inflammatory responses including NF-κB-dependent CXCL-1 secretion from lung epithelial cells. HIF-1 activation in lung epithelial cells is an anti-inflammatory response to alveolar hypoxia in atelectatic lungs. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 19, 2015 Category: Surgery Authors: Kentaro TojoYusuke NagamineTakuya YazawaTakahiro MiharaYasuko BabaShuhei OtaTakahisa GotoKiyoyasu Kurahashi Source Type: research

Chromosomal abnormalities and autism
Conclusion Chromosomal abnormalities were not detected in the studied autistic children, and so the relation between the genetics and autism still needs further work up with different study methods and techniques. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - June 19, 2015 Category: Genetics & Stem Cells Source Type: research

[In Brief] This week's section
In science news around the world, Paris's historic Musee de l'Homme is set to reopen in October after a 6-year hiatus, a joint mission of health experts says South Korea's outbreak of Middle East respiratory syndrome may now be contained, the International Energy Agency finds that nations' current promised greenhouse gas emissions cuts won't be enough to slow global warming for more than a few months, a leaked version of Pope Francis's climate encyclical reveals that the Vatican firmly blames the burning of fossil fuels for climate change, the University of Minnesota announces sweeping changes to how it will protect its re...
Source: Science: Current Issue - June 19, 2015 Category: Science Authors: Science Magazine (mailto:soleditor at aaas.org) Source Type: research

Association between Ambient Air Pollution and Hospital Emergency Admissions for Respiratory and Cardiovascular Diseases in Beijing: a Time Series Study
Conclusion This study further confirmed that short-term exposure to ambient air pollution was associated with increased risk of hospital emergency admissions in Beijing. (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - June 19, 2015 Category: Biomedical Science Source Type: research

A Phenotypic High-Throughput Screen with RSV-Infected Primary Human Small Airway Epithelial Cells (SAECs)
Respiratory syncytial virus (RSV) is a commonly occurring pathogen that can cause severe disease in children, the elderly, and immunocompromised individuals with a large, unmet clinical need. We developed a high-throughput, primary cell-based antiviral RSV assay to enable identification of small molecules using cytopathic effect (CPE) as a phenotypic end point. To provide increased biological relevance, we developed our assay with primary human small airway epithelial cells (SAECs), which originate from known sites of RSV infection and replication instead of a more traditional immortalized cell line. Using purchased low-pa...
Source: Journal of Biomolecular Screening - June 19, 2015 Category: Molecular Biology Authors: Gobel, J., Gartland, M., Gurley, S. H., Kadwell, S., Gillie, D., Moore, C., Goetz, A. Tags: Original Research Source Type: research

Perinatal factors associated with long-term respiratory sequelae in extremely low birthweight infants
Conclusions Within a cohort of ELBW infants, a bubbly/cystic appearance of the lungs in the neonatal period was the strongest determinant of a low FEV1/FVC ratio at school age. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 19, 2015 Category: Perinatology & Neonatology Authors: Hirata, K., Nishihara, M., Shiraishi, J., Hirano, S., Matsunami, K., Sumi, K., Wada, N., Kawamoto, Y., Nishikawa, M., Nakayama, M., Kanazawa, T., Kitajima, H., Fujimura, M. Tags: Bronchopulmonary dysplasia, Epidemiologic studies, Immunology (including allergy), Pregnancy, Child health, Developmental paediatrics, Airway biology Original articles Source Type: research

A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: childhood outcomes at 5 years
Conclusions The administration of GM-CSF to very preterm SGA babies is not associated with improved or more adverse neurodevelopmental, general health or educational outcomes at 5 years. Trial registration number ISRCTN42553489. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 19, 2015 Category: Perinatology & Neonatology Authors: Marlow, N., Morris, T., Brocklehurst, P., Carr, R., Cowan, F., Patel, N., Petrou, S., Redshaw, M., Modi, N., Dore, C. J. Tags: Open access, Immunology (including allergy), Child health, Infant health, Neonatal health Original articles Source Type: research

In vitro study on work of breathing during non-invasive ventilation using a new variable flow generator
Conclusions This in vitro study shows that a new generator of the Infant Flow SiPAP device results in a significant reduction in WOB and an increase in PA and PB during BPAP. The results of this study need to be confirmed under variable clinical conditions in preterm infants. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 19, 2015 Category: Perinatology & Neonatology Authors: Flink, R. C., van Kaam, A. H., de Jongh, F. H. Tags: Child health, Infant health, Neonatal health, Airway biology Original articles Source Type: research

Development and validation of a simple algorithm for initiation of CPAP in neonates with respiratory distress in Malawi
Conclusions The TRY CPAP algorithm has the potential to be a simple and reliable tool to assist nurses and clinicians in identifying neonates who require treatment with CPAP in low-resource settings. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 19, 2015 Category: Perinatology & Neonatology Authors: Hundalani, S. G., Richards-Kortum, R., Oden, M., Kawaza, K., Gest, A., Molyneux, E. Tags: Epidemiologic studies, Open access Original articles Source Type: research

Total intravenous anaesthesia in adult mules
Conclusions and clinical relevanceThe combination of xylazine–diazepam–ketamine provides effective short‐term anaesthesia in mules under field conditions. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - June 19, 2015 Category: Veterinary Research Authors: Khadim H Dar, Ajay K Gupta Tags: Short Communication Source Type: research

Antiviral agents against equid alphaherpesviruses: current status and perspectives.
Publication date: Available online 12 June 2015 Source:The Veterinary Journal Author(s): María A. Vissani , Etienne Thiry , Fabiana Dal Pozzo , María Barrandeguy Equid herpesvirus infections cause respiratory, neurological and reproductive syndromes. Despite preventive and control measures and the availability of vaccines and immunostimulants, herpesvirus infections still constitute a major threat to equine health and for the equine industry worldwide. Antiviral drugs, particularly nucleoside analogues and foscarnet, are successfully used for the treatment of human alphaherpesvirus infections. In equine medicine, the u...
Source: The Veterinary Journal - June 19, 2015 Category: Veterinary Research Source Type: research

The retrotrapezoid nucleus stimulates breathing by releasing glutamate in adult conscious mice
This article is protected by copyright. All rights reserved. (Source: European Journal of Neuroscience)
Source: European Journal of Neuroscience - June 19, 2015 Category: Neuroscience Authors: Benjamin B. Holloway, Kenneth E. Viar, Ruth L. Stornetta, Patrice G. Guyenet Tags: Research Report Source Type: research

Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma
Conclusions We reveal that the spectrum of GBM-associated mtDNA mutations is wider than previously thought, as well as novel structural-functional links between specific mtDNA mutations, abnormal mitochondria, and the biology of GBM. These results could provide tangible new prognostic indicators as well as targets with which to guide the development of patient-specific mitochondrially mediated chemotherapeutic approaches. (Source: Neuro-Oncology)
Source: Neuro-Oncology - June 19, 2015 Category: Cancer & Oncology Authors: Lloyd, R. E., Keatley, K., Littlewood, D. T. J., Meunier, B., Holt, W. V., An, Q., Higgins, S. C., Polyzoidis, S., Stephenson, K. F., Ashkan, K., Fillmore, H. L., Pilkington, G. J., McGeehan, J. E. Tags: Basic and Translational Investigations Source Type: research

Fatal Progression of Gorham Disease: a case report and review of the literature
Gorham disease is an idiopathic massive osteolysis, and maxillofacial involvement is rare. Here, we report a case of a 12-year-old boy suffering from severe progressive osteolysis in the mandible, hyoid bone, mastoid process, and cervical spine. Radiation therapy and α-interferon therapy were followed by bisphosphonate therapy. The patient died due to respiratory failure. To describe the clinicopathological features of Gorham disease of the jaws with emphasis on the fatal types, 64 cases in the literature were reviewed. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - June 19, 2015 Category: ENT & OMF Authors: Min-Keun Kim, Jong-Rak Hong, Seong-Gon Kim, Seok-Keun Lee Tags: Case Report Source Type: research

Radiologic manifestations of pulmonary tuberculosis in patients of intensive care units
Conclusion ARDS, interstitial involvement, and Parenchymal nodular infiltration are the most common manifestations of pulmonary TB. Various features of TB in ICU patients could be misleading for intensivists. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - June 19, 2015 Category: Infectious Diseases Source Type: research

Increased intra- and extracellular granzyme expression in patients with tuberculosis
Tuberculosis (TB) is an important cause of morbidity and mortality worldwide. Granzymes (gzms) are proteases mainly found in cytotoxic lymphocytes, but also extracellularly. While the role of gzms in target cell death has been widely characterized, considerable evidence points towards broader roles related to infectious and inflammatory responses. To investigate the expression of the gzms in TB, intracellular gzms A, B and K were measured by flow cytometry in lymphocyte populations from peripheral blood mononuclear cells from 18 TB patients and 12 healthy donors from Bangladesh, and extracellular levels of gzmA and B were ...
Source: Tuberculosis - June 19, 2015 Category: Respiratory Medicine Authors: M.Isabel Garcia-Laorden, Dana C. Blok, Liesbeth M. Kager, Arie J. Hoogendijk, Gerard J. van Mierlo, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Aniruddha Ghose, Caroline E. Visser, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Ba Tags: Immunological Aspects Source Type: research

Inhaled carbon dioxide causes dose-dependent paradoxical bradypnea in animals anesthetized with pentobarbital, but not with isoflurane or ketamine.
Conclusions Inhaled CO2 caused paradoxical dose-dependent bradypnea in animals anesthetized with pentobarbital, an observation not hitherto reported as a part of anesthesia-related respiratory depression. (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - June 19, 2015 Category: Respiratory Medicine Source Type: research

Ventilation and Diaphragm Activity during Sustained Hypoxia in Awake Canines
We examined the effect of moderate isocapnic hypoxia (SpO2 80%) sustained for 20minutes in 13 adult, awake, intact canines. The ventilatory response to sustained isocapnic hypoxia in these canines was not maintained: after an initial brisk response, ventilation declined significantly to an intermediate plateau. The hypoxic ventilatory decline occurred via a decrease in tidal volume, without change in breathing frequency. Distinct from airflow, costal diaphragm EMG showed a concurrent decline during sustained isocapnic hypoxia. However, the change in ventilation during sustained hypoxia in canines was very different from th...
Source: Respiratory Physiology and Neurobiology - June 19, 2015 Category: Respiratory Medicine Source Type: research

Cause‐Specific Mortality in US Veteran Men with Rheumatoid Arthritis
Conclusions. Men in this RA cohort experienced increased all‐cause and cause‐specific mortality, with a 3‐fold risk of respiratory‐related deaths compared to age‐matched men in the general population. Further studies are needed to examine whether interventions targeting potentially “modifiable” correlates of mortality might lead to improved long‐term survival in men with RA. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - June 19, 2015 Category: Rheumatology Authors: Bryant R. England, Harlan Sayles, Kaleb Michaud, Liron Caplan, Lisa A. Davis, Grant W. Cannon, Brian C. Sauer, Elizabeth B. Solow, Andreas M. Reimold, Gail S. Kerr, Pascale Schwab, Josh F. Baker, Ted R. Mikuls Tags: Original Article Source Type: research

Physiological responses and characteristics of sperm collected after electroejaculation or transrectal ultrasound-guided massage of the accessory sex glands in anesthetized mouflons () and Iberian ibexes ()
The objective was to characterize the stress response and the seminal parameters obtained with electroejaculation (EE) or transrectal ultrasound-guided massage of the accessory sex glands (TUMASG) in two captive but non-domestic ruminants, the mouflons and the Iberian ibex under general anesthesia. In mouflons, the physiological responses (heart and respiratory rate, rectal temperature, cortisol, creatin kinase, potassium and glucose concentrations) changed similarly with both procedures. The TUMASG procedure was faster than EE in mouflons (21.7 ± 1.4 min vs 12.4 ± 1.2 min, P (Source: Theriogenology)
Source: Theriogenology - June 19, 2015 Category: Genetics & Stem Cells Authors: Rodolfo Ungerfeld, Antonio López-Sebastián, Milagros Esteso, Jorgea Pradiee, Adolfo Toledano-Díaz, Cristina Castaño, Beatriz Labrador, Julián Santiago-Moreno Source Type: research

Neutralization of enterovirus D68 isolated from the 2014 US outbreak by commercial intravenous immune globulin products
Enterovirus D68 (EV-D68) belongs to the Enterovirus genus (Picornaviridae family) of non-enveloped, positive sense, single-stranded RNA viruses that commonly infect humans. Initially isolated from children with pneumonia and bronchiolitis in 1962, EV-D68 has been the cause of isolated clusters of acute respiratory disease in children in the United States from 1989 to 2010[1,2]. The recent 2014 outbreak represents the largest and most widespread EV-D68 outbreak to date with 1153 laboratory-confirmed cases since August [3]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 19, 2015 Category: Virology Authors: Yiting Zhang, Deborah D. Moore, W. Allan Nix, M. Steven Oberste, William C. Weldon Tags: Short Communication Source Type: research

Linear and nonlinear dynamics of heart rate variability in the process of exposure to 3600 m in 10 min
Abstract Acute hypoxia activates several autonomic mechanisms, mainly in cardiovascular system and respiratory system. The influence of acute hypoxia on linear and nonlinear heart rate variability (HRV) has been studied, but the parameters in the process of hypoxia are still unclear. Although the changes of HRV in frequency domain are related to autonomic responses, how nonlinear dynamics change with the decrease of ambient atmospheric pressure is unknown either. Eight healthy male subjects were exposed to simulated altitude from sea level to 3600 m in 10 min. HRV parameters in frequency domain were analyzed by ...
Source: Australasian Physical and Engineering Sciences in Medicine - June 19, 2015 Category: Biomedical Engineering Source Type: research

Duration of wheezy episodes in early childhood is independent of the microbial trigger
Wheezy episodes in young children are often triggered by viral and bacterial respiratory tract infections, but there is little evidence supporting the hypothesis that symptom duration depends on the specific microbial trigger. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - June 19, 2015 Category: Allergy & Immunology Authors: Christian J. Carlsson, Nadja H. Vissing, Astrid Sevelsted, Sebastian L. Johnston, Klaus Bønnelykke, Hans Bisgaard Source Type: research

Platelet-rich Plasma Extract Accelerates Lung Regeneration Through the LRP5-Tie2 Pathway.
In this report, we have demonstrated that mouse PRP extract increases phosphorylation levels of the Wnt co-receptor low-density lipoprotein receptor-related protein 5 (LRP5), and thereby activates angiogenic factor receptor Tie2 in endothelial cells (ECs) and accelerates EC sprouting and lung epithelial cell budding in vitro. PRP extract also increases phosphorylation levels of Tie2 in the mouse lungs and accelerates compensatory lung growth and recovery of exercise capacity after unilateral pneumonectomy in mice, while soluble Tie2 receptor or Lrp5 knockdown attenuates the effects of PRP extract. Since human PRP extract i...
Source: Am J Respir Cell Mol... - June 19, 2015 Category: Respiratory Medicine Authors: Mammoto T, Chen Z, Jiang A, Jiang E, Ingber DE, Mammoto A Tags: Am J Respir Cell Mol Biol Source Type: research

Deficiency Mutations of α1-antitrypsin Differentially Affect Folding, Function and Polymerization.
Abstract Misfolding, polymerisation and defective secretion of functional α1-antitrypsin underlies the predisposition to severe liver and lung disease in α1-antitrypsin deficiency. We have identified a novel (Ala336Pro, Baghdad) deficiency variant and characterised it relative to the wild-type (M) and Glu342Lys (Z) alleles. The index case is a homozygous individual of consanguineous parentage, with levels of circulating α1-antitrypsin in the moderate deficiency range, but a biochemical phenotype that could not be classified by standard methods. The majority of the protein was present as functionally inactive pol...
Source: Am J Respir Cell Mol... - June 19, 2015 Category: Respiratory Medicine Authors: Haq I, Irving JA, Saleh AD, Dron L, Regan-Mochrie GL, Motamedi-Shad N, Hurst JR, Gooptu B, Lomas DA Tags: Am J Respir Cell Mol Biol Source Type: research

Opioid Overdose Prevention Programs Providing Naloxone to Laypersons - United States, 2014.
Abstract Drug overdose deaths in the United States have more than doubled since 1999. During 2013, 43,982 drug overdose deaths (unintentional, intentional [suicide or homicide], or undetermined intent) were reported. Among these, 16,235 (37%) were associated with prescription opioid analgesics (e.g., oxycodone and hydrocodone) and 8,257 (19%) with heroin. For many years, community-based programs have offered opioid overdose prevention services to laypersons who might witness an overdose, including persons who use drugs, their families and friends, and service providers. Since 1996, an increasing number of programs ...
Source: MMWR Morb Mortal Wkl... - June 19, 2015 Category: Epidemiology Authors: Wheeler E, Jones TS, Gilbert MK, Davidson PJ Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Linear and nonlinear dynamics of heart rate variability in the process of exposure to 3600 m in 10 min.
Abstract Acute hypoxia activates several autonomic mechanisms, mainly in cardiovascular system and respiratory system. The influence of acute hypoxia on linear and nonlinear heart rate variability (HRV) has been studied, but the parameters in the process of hypoxia are still unclear. Although the changes of HRV in frequency domain are related to autonomic responses, how nonlinear dynamics change with the decrease of ambient atmospheric pressure is unknown either. Eight healthy male subjects were exposed to simulated altitude from sea level to 3600 m in 10 min. HRV parameters in frequency domain were analyzed by w...
Source: Physica Medica - June 19, 2015 Category: Physics Authors: Zhang D, She J, Yang J, Yu M Tags: Australas Phys Eng Sci Med Source Type: research

Identification of a short interspersed repetitive element insertion polymorphism in the porcine MX1 promoter associated with resistance to porcine reproductive and respiratory syndrome virus infection.
In this study, we demonstrate that positive elements are present in the two promoter regions of -2713 to -2565 and -688 to -431 in the porcine MX1 gene. Sequencing and alignment of the amplified porcine MX1 gene promoter region identified a short interspersed repetitive element (SINE) insertion of 275 bp at site -547. At this site, allele B (an insertion of 275 bp) is dominant in Chinese indigenous pig breeds but has a workable minor allele frequency in western lean-type pig breeds. Luciferase activity was compared between promoters with and without the insertion of the 275-bp fragment in transiently transfected MARC-145...
Source: Animal Genetics - June 19, 2015 Category: Genetics & Stem Cells Authors: Li Y, Liang S, Liu H, Sun Y, Kang L, Jiang Y Tags: Anim Genet Source Type: research

Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction.
Abstract Infection with viral or bacterial pathogens has been linked with the development of multiple sclerosis (MS), while infection with helminth parasites has been associated protection against MS and other autoimmune diseases. Here we have used a murine model of MS, experimental autoimmune encephalomyelitis (EAE), to examine the effect of infection with the respiratory pathogen Bordetella pertussis infection on development of CNS inflammation. The data demonstrate that infection of mice with B. pertussis significantly attenuates the clinical course of EAE induced by active immunization or cell transfer. This wa...
Source: Brain, Behavior, and Immunity - June 19, 2015 Category: Neurology Authors: Edwards SC, Higgins SC, Mills KH Tags: Brain Behav Immun Source Type: research

Pleuroparenchymal Fibroelastosis: Is it Also an Idiopathic Entity?
Abstract Pleuroparenchymal fibroelastosis (PPFE) is a rare disease that has been recently included in the updated consensus on idiopathic interstitial pneumonias. It shares some clinical features with other chronic interstitial pneumonias (dyspnea, dry cough), and is radiologically characterized by pleural and subpleural parenchymal fibrosis and elastosis, mainly in the upper lobes. The main histological findings include pleural fibrosis and prominent subpleural and parenchymal fibroelastosis. Its characterization is based on the increasing number of cases reported in the literature, so several aspects of the etiol...
Source: Archivos de Bronconeumologia - June 19, 2015 Category: Respiratory Medicine Authors: Portillo K, Guasch Arriaga I, Ruiz-Manzano J Tags: Arch Bronconeumol Source Type: research

Validation and clinical application of a nested PCR for paracoccidioidomycosis diagnosis in clinical samples from Colombian patients.
Abstract Paracoccidioidomycosis is a systemic and endemic mycosis, restricted to tropical and subtropical areas of Latin America. The infection is caused by the thermal dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii. The diagnosis of paracoccidioidomycosis is usually performed by microscopic examination, culture and immunodiagnostic tests to respiratory specimens, body fluids and/or biopsies; however these methods require laboratory personnel with experience and several days to produce a result. In the present study, we have validated and evaluated a nested PCR assay targeting the gene e...
Source: Braz J Infect Dis - June 19, 2015 Category: Infectious Diseases Authors: Gaviria M, Rivera V, Muñoz-Cadavid C, Cano LE, Naranjo TW Tags: Braz J Infect Dis Source Type: research

Augmented Carbohydrate Oxidation under Moderate Hypobaric Hypoxia Equivalent to Simulated Altitude of 2500 m.
In conclusion, acute exposure to moderate hypobaric hypoxia significantly augmented carbohydrate oxidation following the glucose load, without affecting glucose or insulin responses. Thus, a short-time exposure to moderate hypobaric hypoxia may be beneficial for people with impaired glucose tolerance. PMID: 26072915 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - June 18, 2015 Category: Research Authors: Goto K, Morishima T, Kurobe K, Huang Z, Ogita F Tags: Tohoku J Exp Med Source Type: research

Home Oxygen Program review: Regionalization in Vancouver Coastal Health and British Columbia.
Abstract Since its inception in the 1980s, the Home Oxygen Program in British Columbia was centrally managed by the Ministry of Health. Initially a small program with few clients across the province, it soon became a large program with many clients and increasing expenditures. A pilot program started in Victoria (British Columbia) in 1996 demonstrated that managing the program locally could offer better client care, better contract management and significant cost savings. In 2002, the pilot's model and recommendations were implemented in British Columbia's five health authorities. The present review details the exp...
Source: Respiratory Care - June 18, 2015 Category: Respiratory Medicine Authors: Sandberg D Tags: Can J Respir Ther Source Type: research